Category	Group	Type	Subtype_name	Subtype	req_domain_code	Required_domains	less_strict	Alt_req	Cannot_have	Uniprot_human	Uniprot_DroMel	citation	DOI	Link
IMMUNITY	Effector Genes	AMP	Aerolysin	Aerolysin	Aerolysin	IPR005830						Lacomel et al. 2021	10.1016/j.jip.2021.107570	https://www.sciencedirect.com/science/article/pii/S0022201121000379?via%3Dihub
IMMUNITY	Effector Genes	AMP	Big defensin	Big defensin	Defensin_big_dom	IPR028060						Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	AMP	defensin	defensin	defensine	IPR001542						Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	AMP	Epsilon toxin	ETX/MTX-2	Aerolysin-like	IPR004991						Lacomel et al. 2021	10.1016/j.jip.2021.107570	https://www.sciencedirect.com/science/article/pii/S0022201121000379?via%3Dihub
IMMUNITY	Effector Genes	AMP	Lipopolysaccharide-binding protein/Bactericidal/permeability-increasing protein	LBP/BPI	"Lipid-bd_serum_glycop_C, Lipid-bd_serum_glycop_N"	"IPR001124,IPR017942"	IPR030675			P17213		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	AMP	Macins	Macins	Macin	IPR029230	IPR038456					Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	AMP	MACPF domain containing protein (Perfoin-like)	MACPF	MACPF	IPR020864				P14222		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	AMP	Mucin	Mucin	SEA_dom	IPR000082	IPR036364			"P15941,Q02817,Q02505,Q99102,Q9HC84,Q6W4X9,Q8TAX7"		Buddenbor et al. 2017	10.1371/journal.pntd.0005984	https://www.ncbi.nlm.nih.gov/pubmed/29045404
IMMUNITY	Effector Genes	AMP	Myticin	Myticin	Myticin_preproprotein	IPR019631						Philipp et al. 2012	10.1371/journal.pone.0033091	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308963/
IMMUNITY	Effector Genes	Antioxidants	Catalase	CAT	Catalase_core	IPR011614				P04040		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	Antioxidants	Glutaredoxin	GRX	Glutaredoxin	IPR002109				"P35754,Q9NS18,O76003,Q86SX6"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Antioxidants	Glutathion S transferase	GST	"GST_C, GST_N"	"IPR004046,IPR004045"	IPR010987			"P08263,P09210,Q16772,O15217,P09488,P28161,P21266,Q03013,P46439,P09211,Q9Y2Q3,P30711"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Antioxidants	Glutathione peroxidase	GPX	GPX_CS	IPR029760	IPR000889			"P07203,P18283,P22352,P36969,O75715,P59796,Q96SL4,Q8TED1"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Antioxidants	Glutathione reductase	GSR	"FAD/NAD-binding_dom,Pyr_nucl-diS_OxRdtase_dimer"	"IPR023753,IPR004099,IPR006322"	"IPR006322,IPR036188,IPR016156"			P00390		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Antioxidants	Nucleoredoxin	NXN	TryX_NRX_thioredoxin_dom	IPR045870				Q6DKJ4		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Antioxidants	Peroxidases	PRX	Haem_peroxidase_animal	IPR019791	IPR037120			Q9VEG6		Buddenbor et al. 2017	10.1371/journal.pntd.0005984	https://www.ncbi.nlm.nih.gov/pubmed/29045404
IMMUNITY	Effector Genes	Antioxidants	Peroxiredoxin	PRDX	AhpC/TSA	IPR000866	"IPR013766,IPR019479"			"Q06830,P32119,P30048,Q13162,P30044,P30041"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Antioxidants	Superoxide Dismutase (Cu/Zn)	SOD	SOD_Cu_Zn_dom	IPR001424		"IPR019832,IPR019831"		"P00441,P08294"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	Antioxidants	Superoxide Dismutase (Mn/Fe)	MnSOD	"Mn/Fe_SOD_C,Mn/Fe_SOD_N"	"IPR019832,IPR019831"				P04179		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Antioxidants	thioredoxin domain-containing protein	TRXDC	Thioredoxin_domain	IPR013766				P10599		Buddenbor et al. 2017	10.1371/journal.pntd.0005984	https://www.ncbi.nlm.nih.gov/pubmed/29045404
IMMUNITY	Effector Genes	Antiviral	Apolipoprotein B Editing Complex 3 proteins	APOBEC3	"CMP_dCMP_dom,APOBEC/CMP_deaminase_Zn-bd"	"IPR002125,IPR016192"	IPR040551			"Q96AK3,Q9HC16,Q8IUX4,Q6NTF7,Q9NRW3,Q9UH17,P31941"		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
IMMUNITY	Effector Genes	Antiviral	Caveolin	CAV	Caveolin_CS	IPR018361	IPR001612			Q03135		Green et al. 2015	10.1099/jgv.0.000244	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000244#tab2
IMMUNITY	Effector Genes	Antiviral	Deoxynucleoside triphosphate triphosphohydrolase SAMHD	SAMHD	"SAM, HD_dom"	"IPR001660,IPR006674"	"IPR013761,IPR003607"			Q9Y3Z3		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
IMMUNITY	Effector Genes	Antiviral	Double-stranded RNA-specific adenosine deaminase	ADAR	"A_deamin,ADAR1_DSRM_1,ADAR1_DSRM_3,dsRBD_dom,Z_dom"	"IPR002466,IPR044456,IPR044457,IPR014720,IPR042371"	"IPR002466,IPR014720,IPR042371"			"P55265,P78563"	Q9NII1	Lamers et al. 2019	10.3389/fimmu.2019.01763	https://www.frontiersin.org/articles/10.3389/fimmu.2019.01763/full
IMMUNITY	Effector Genes	Antiviral	Gilt	Gilt	Interferon-induced_GILT	IPR004911				P13284		Green et al. 2016	10.1186/s13567-016-0356-7	https://pubmed.ncbi.nlm.nih.gov/27439510/
IMMUNITY	Effector Genes	Antiviral	Interferon-induced GTP-binding protein Mx	Mx	"GED,Dynamin_GTPase,Dynamin_stalk,Dynamin_N"	"IPR003130,IPR001401,IPR000375,IPR045063"	"IPR020850,IPR030381,IPR027417"			P20591		Green et al. 2015	10.1099/jgv.0.000244	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000244#tab2
IMMUNITY	Effector Genes	Antiviral	Interferon-induced protein 44 	IFI44	"TLDc_dom,P-loop_NTPase"	"IPR006571,IPR027417"	IPR024644			Q8TCB0		Green and Speck 2018	10.3390/v10030133	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/
IMMUNITY	Effector Genes	Antiviral	Interferon-induced transmembrane protein-like	IFITML	CD225/Dispanin_fam	IPR007593				"P13164,Q01629,Q01628,A6NNB3"		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
IMMUNITY	Effector Genes	Antiviral	Protein mono-ADP-ribosyltransferase	PARPs	Poly(ADP-ribose)pol_cat_dom	IPR012317				"P09874,Q9UGN5,Q9Y6F1,Q9UKK3,O95271,Q2NL67,Q7Z3E1,Q8N3A8,Q8IXQ6,Q53GL7,Q9NR21,Q9H0J9,Q3UPF5,Q460N5,Q460N3,Q8N5Y8"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Antiviral	Ribonuclease L	RNASEL	"Ankyrin_rpt, RNase-L_Rnase,Prot_kinase_dom"	"IPR002110,IPR042745,IPR000719"	"IPR036770,IPR010513,IPR011009"			Q05823		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
IMMUNITY	Effector Genes	Antiviral	Tetherines (Bone marrow stromal antigen 2-like)	BST2L	BST2	IPR024886				Q10589		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
IMMUNITY	Effector Genes	Antiviral	Tripartite motif-containing protein 5	TRIM5	"SPRY,Znf-RING_LisH,Znf_B-box"	"IPR003877,IPR027370,IPR000315"	"IPR043136,IPR000315,IPR013083"			Q9C035		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
IMMUNITY	Effector Genes	Antiviral	viperins (Radical S-adenosyl methionine domain-containing proteins)	RSADs	"rSAM,Aldolase_TIM"	"IPR007197,IPR013785"				"Q9HA92,Q8WXG1"		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
IMMUNITY	Effector Genes	Antiviral	zinc finger NFX1-type containing 1	ZNFX1	"DNA2/NAM7_AAA_11,DNA2/NAM7-like_C,Znf_NFX1,ARM-type_fold"	"IPR041677,IPR041679,IPR000967,IPR016024"	"IPR045055,IPR041677,IPR041679"			Q9P2E3		Blasi et al. 2022	10.1016/j.fsi.2022.01.019	https://www.sciencedirect.com/science/article/pii/S1050464822000286#appsec1
IMMUNITY	Effector Genes	Antiviral	Zinc-finger antiviral proteins	ZAP	"Poly(ADP-ribose)pol_cat_dom, WWE-dom, ZAP_HTH,Znf-CCCH_8,Znf_CCCH"	"IPR012317,IPR004170,IPR041360,IPR040954,IPR000571"	"IPR004170,IPR041360,IPR040954,IPR000571"			Q7Z2W4		Meagher et al. 2019	10.1073/pnas.1913232116	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883784/
IMMUNITY	Effector Genes	Autophagy	Beclin	Beclin	"Atg6/beclin_CC,Atg6_BARA,BH3_dom"	"IPR041691,IPR040455,IPR029318"	IPR038274			Q14457		Green et al. 2016	10.1186/s13567-016-0356-7	https://pubmed.ncbi.nlm.nih.gov/27439510/
IMMUNITY	Effector Genes	Complement	alpha-2-macroglobulin containing proteins	A2M	Macroglobln_a2	IPR001599				P01023		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	Complement	C1q domain containing proteins 	C1qDC	C1qD	IPR001073						Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	Complement	Cluster of Differentiation 109	CD109	"A-macroglobulin_rcpt-bd,A2M_N_BRD,A2M_TED,Macroglobln_a2,MG2,MG3"	"IPR009048,IPR011625,IPR041813,IPR013783,IPR001599,IPR002890,IPR041555"	"IPR036595,IPR011626,IPR011625,IPR041813,IPR013783,IPR001599"		"IPR010916,IPR040839"	Q6YHK3		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	Complement	Complement proteins 3/4/5	C3/4/5	"Netrin_domain,A-macroglobulin_rcpt-bd,Alpha-macroglobulin_TED"	"IPR001134,IPR009048,IPR011626"	"IPR008993,IPR036595"			"P01024,P0C0L4,P0C0L5,P01031"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	Complement	Factor B-like	CFB	"VWF_A,Sushi_SCR_CCP_dom,Trypsin_dom"	"IPR002035,IPR000436,IPR001254"	IPR011360			P00751		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	Complement	Multiple epidermal growth factor-like domains protein 10	MEGF10	"EGF-like_Ca-bd_dom,EGF-like_dom,EMI_domain"	"IPR001881,IPR000742,IPR011489"				Q96KG7		Green et al. 2016	10.1186/s13567-016-0356-7	https://pubmed.ncbi.nlm.nih.gov/27439510/
IMMUNITY	Effector Genes	Complement	thioester containing protein (thioester)	TEP	Alpha-macroglobulin_TED	IPR011626						Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Effector Genes	E3 Ubiquitin ligases	Cullin	CUL	Cullin_homology	IPR016158	IPR036317			Q13616		Li et al. 2022	10.1007/s00251-021-01236-3	https://pubmed.ncbi.nlm.nih.gov/34854945/
REGULATORY PATHWAYS	Effector Genes	E3 Ubiquitin ligases	F-box/LRR-repeat protein	FBXL	"F-box_dom, LRR_dom_sf"	"IPR001810,IPR032675"	"IPR036047,IPR032675"			"Q9UKC9,Q9UKT7"		Li et al. 2022	10.1007/s00251-021-01236-3	https://pubmed.ncbi.nlm.nih.gov/34854945/
REGULATORY PATHWAYS	Effector Genes	E3 Ubiquitin ligases	S-phase kinase-associated protein 1	SKIP1	"Skp1_comp_POZ,Skp1_comp_dimer"	"IPR016073,IPR016072"	"IPR011333,IPR036296"			Q13616		Li et al. 2022	10.1007/s00251-021-01236-3	https://pubmed.ncbi.nlm.nih.gov/34854945/
REGULATORY PATHWAYS	Effector Genes	E3 Ubiquitin ligases	Tumor necrosis factor alpha-induced protein 3/A20-like	TNAP3/A20	"Znf_A20,OTU_dom"	"IPR002653,IPR003323"	IPR033478			P21580		Philipp et al. 2012	10.1371/journal.pone.0033091	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308963/
IMMUNITY	Effector Genes	Lysozyme	Lysozyme	Lysozyme	Glyco_hydro_22_CS	IPR019799	IPR023346			P61626		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	Metabolism	Alcohol dehydrogenase-like	ADH	ADH-like_C	IPR013149				"P07327,P00325,P00326,P08319,P40394,P11766"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Metabolism	Estrogen receptor/oestrogen-related receptors	ERR	"Nucl_hrmn_rcpt_lig-bd,Znf_hrmn_rcpt,Est_rcpt/est-rel_rcp"	"IPR000536,IPR001628,IPR024178"	IPR024178			"P11474,O95718"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Metabolism	Ferritins	Ferritin	Ferritin_DPS_dom	IPR008331	IPR001519			"P02792,P02794"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Metabolism	Retinoid X receptor	RXR	"Retinoid-X_rcpt/HNF4,Znf_hrmn_rcpt,Nucl_hrmn_rcpt_lig-bd,Nuc_recep-AF1"	"IPR000003,IPR001628,IPR000536,IPR021780"	IPR000003			"P19793,P28704,P48443"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Metabolism	Serine/threonine-protein phosphatase PP1	PP1	"Ser/Thr-sp_prot-phosphatase,STPPase_N"	"IPR006186,IPR031675"	IPR037979			"P62136,P62140,P36873"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Metabolism	Ubiquitin-like proteins	Ubiquitin-like	Ubiquitin-like_dom	IPR000626						Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Phenoloxidase/melanisation-type reaction	Laccase 	Laccase 	"CuRO_1_LCC,CuRO_2_LCC"	"IPR034288,IPR034285"	IPR001117			Q8IV20		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Phenoloxidase/melanisation-type reaction	Phenoloxidase	proPO	"Hemocyanin/hexamerin_mid_dom,Hemocyanin_C,Hemocyanin_N,Tyrosinase_Cu-bd,Ig_E-set"	"IPR000896,IPR005203,IPR005204,IPR002227,IPR014756"	"IPR008922,IPR037020,IPR036697"				"Q9V521,Q9W1V6"	Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Phenoloxidase/melanisation-type reaction	Tyrosinase	Tyrosinase	Tyrosinase_Cu-bd	IPR002227				"P14679,P17643"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	RNAi	Argonaute	AGO	"Argonaute_Mid_dom,Argonaute_N,PAZ_dom,Piwi,ArgoL1,ArgoL2"	"IPR032473,IPR032474,IPR003100,IPR003165,IPR014811,IPR032472"	"IPR003165,IPR036085,IPR032473"			Q9UKV8		Green and Speck 2018	10.3390/v10030133	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/
IMMUNITY	Effector Genes	RNAi	Dicer	Dicer	"DICER_DSRM,RNase_III_dom,PAZ_dom"	"IPR044441,IPR000999,IPR003100"	"IPR014720,IPR038248,IPR036085,IPR036389"			Q9UPY3		Green and Speck 2018	10.3390/v10030133	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/
IMMUNITY	Effector Genes	RNAi	Piwi-like 	PIWI	"Piwi,ArgoL1,PAZ_dom"	"IPR003165,IPR014811,IPR003100"	IPR003165			Q96J94		Buddenbor et al. 2017	10.1371/journal.pntd.0005984	https://www.ncbi.nlm.nih.gov/pubmed/29045404
IMMUNITY	Effector Genes	RNAi	RISC-loading complex subunit TARBP	TRBP	"TRBP2_DSRM_1,TRBP2_DSRM_2,TRBP2_DSRM_3"	"IPR044469,IPR044470,IPR044471"	"IPR014720,IPR028605"			Q15633		Green et al. 2015	10.1099/jgv.0.000244	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000244#tab2
IMMUNITY	Effector Genes	ROS	Dual oxidase	DUOX	"EF-hand-dom_pair, EF_hand_dom, FAD-bd_8, FAD-bd_FR_type, Fe3_Rdtase_TM_dom, FNR_nucleotide-bd, Haem_peroxidase_animal, Riboflavin_synthase-like_b-brl"	"IPR011992,IPR002048,IPR013112,IPR017927,IPR013130,IPR039261,IPR019791,IPR017938"				"Q9NRD9,Q9NRD8"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	ROS	Dual oxidase maturation factor	DUOXA	Dual_oxidase_maturation_fac	IPR018469				"Q1HG43,Q1HG44"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	ROS	L-Amino Oxidase	LAAO 	Amino_oxidase	IPR002937				Q96RQ9		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	ROS	NADPH oxidase	NOX	"FAD-bd_FR_type,Fe3_Rdtase_TM_dom,Fe_red_NAD-bd_6"	"IPR017927,IPR013130,IPR013121"	IPR000778			"Q9Y5S8,Q9HBY0,Q9NPH5"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	ROS	Nitric-oxide synthase	NOS	"NOS_N,Flavodoxin/NO_synt"	"IPR004030,IPR008254"	IPR008254			"P29475,P35228,P29474"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Effector Genes	ROS	Peroxidasin	PRXDN	Peroxidasin_peroxidase	IPR034824	IPR029610			"Q92626,A1KZ92"	Q9VZZ4	Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Stress responses	Heat shock 20 kDa protein	HSP20	A-crystallin/Hsp20_dom	IPR002068	IPR008978					Green et al. 2016	10.1186/s13567-016-0356-7	https://pubmed.ncbi.nlm.nih.gov/27439510/
IMMUNITY	Effector Genes	Stress responses	Heat shock 70 kDa protein	HSP70	Heat_shock_70_CS	IPR018181	IPR013126			"P0DMV8,P0DMV9,P34931"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Stress responses	Heat shock 90 kDa protein	HSP90	"Heat_shock_protein_90_CS,Hsp90_N,HATPase_C"	"IPR019805,IPR020575,IPR003594"	IPR001404			"P07900,P08238"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Effector Genes	Stress responses	Heat shock factor protein	HSF	"HATPase_C,HSF_DNA-bd"	"IPR003594,IPR000232"	IPR027725			"Q00613,Q03933"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Immune receptor	DExD/H-box helicases	ATP-dependent RNA helicase DDX1	DDX1	"DEAD/DEAH_box,SPRY_dom,B30.2/SPRY"	"IPR011545,IPR003877,IPR001870"	"IPR011545,IPR027417,IPR043136"			Q92499		Su et al. 2022	10.1007/s00018-021-04072-6	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/
IMMUNITY	Immune receptor	DExD/H-box helicases	ATP-dependent RNA helicase DDX21	DDX21	"DEAD/DEAH_box,GUCT"	"IPR011545,IPR012562"	"IPR011545,IPR035979"			Q9NR30		Su et al. 2023	10.1007/s00018-021-04072-6	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/
IMMUNITY	Immune receptor	DExD/H-box helicases	ATP-dependent RNA helicase DDX41	DDX41	"DEAD/DEAH_box,DEADc_DDX41"	"IPR011545,IPR044113"				Q9UJV9		Su et al. 2027	10.1007/s00018-021-04072-6	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/
IMMUNITY	Immune receptor	DExD/H-box helicases	ATP-dependent RNA helicase DHX15	DHX15	"DEAD/DEAH_box,DHX15_DEXHc"	"IPR011545,IPR044756"				O43143		Su et al. 2025	10.1007/s00018-021-04072-6	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/
IMMUNITY	Immune receptor	DExD/H-box helicases	ATP-dependent RNA helicase DHX9	DHX9	"DEAD/DEAH_box,DHX9_DSRM_1,DHX9_DSRM_2"	"IPR011545,IPR044445,IPR044446"	"IPR011545,IPR014720"			Q08211		Su et al. 2027	10.1007/s00018-021-04072-6	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/
IMMUNITY	Immune receptor	DExD/H-box helicases	ATP-dependent RNA helicase with DEAD Q motif	DDX_DEAD_Q	"DEAD/DEAH_box,RNA_helicase_DEAD_Q_motif"	"IPR011545,IPR014014"				"O00148,Q13838,Q9UJV9,Q9NY93,Q9NY93,P26196,Q9BUQ8,Q9GZR7,O00571,O15523,Q92841,Q9NUU7,Q9UMR2"		Su et al. 2024	10.1007/s00018-021-04072-6	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/
IMMUNITY	Immune receptor	DExD/H-box helicases	ATP-dependent RNA helicases with Domain of unknown function 1605	DHX_DUF1605	"DEAD/DEAH_box,DUF1605"	"IPR011545,IPR011709"				"Q7L2E3,Q7Z478,Q9H2U1,Q9H6R0,Q7L2E3"		Su et al. 2026	10.1007/s00018-021-04072-6	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8671602/
IMMUNITY	Immune receptor	DExD/H-box helicases	DExD/H-box helicases - other	DExD/H-box	DEAD/DEAH_box	IPR011545			"IPR041204,IPR021673"			Su et al. 2021	10.1007/s00018-021-04072-6	https://pubmed.ncbi.nlm.nih.gov/34910251/
IMMUNITY	Immune receptor	Gene associated with VDJ recombination	RAG-like	RAG-like	C2H2 RAG1-type zinc finger	IPR019485	"IPR018957,IPR035714"			"P15918,P55895"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	lectins	Apextrin	Apextrin	ApeC	IPR031569						Gerdol 2017	10.25431/1824-307X/isj.v14i1.103-118	https://www.isj.unimore.it/index.php/ISJ/article/view/29/332
IMMUNITY	Immune receptor	lectins	C-type lectin domain containing proteins	CTLDC	CTLD	IPR001304	IPR016187					Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	lectins	Chitinases	Chi-lectin	Glyco_hydro18_cat	IPR001223						Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Immune receptor	lectins	F-box domain containing lectins	F-box lectins	"F-box_dom,F-box-assoc_dom,Galactose-bd-like_sf"	"IPR001810,IPR007397,IPR008979"						Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Immune receptor	lectins	Fibrinogen domain containing protein	FBGDC	Fibrinogen_a/b/g_C_dom	IPR002181						Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	lectins	Fucolectin	F-type lectins	FTP1	IPR006585						Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Immune receptor	lectins	Galectin domain containg proteins	Galectin	Gal_CRD	IPR001079						Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	lectins	H-type lectins	H-type lectin	H-type_lectin_domain	IPR019019	IPR037221					Gerdol 2017	10.25431/1824-307X/isj.v14i1.103-118	https://www.isj.unimore.it/index.php/ISJ/article/view/29/332
IMMUNITY	Immune receptor	lectins	immunoglobulin lectins	I-type lectins	Ig_I-set	IPR013098						Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Immune receptor	lectins	Legume-like lectin	L-type lectin	Lectin_leg	IPR005052						Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Immune receptor	lectins	mannose 6-phosphate receptor homology domain containing 	P-type lectin	MRH	IPR044865	IPR009011					Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	lectins	Mannose-binding lectin	MBP	Collectin_CTLD	IPR033990				P48740		Nauta et al. 2003	10.1002/eji.200323888	https://pubmed.ncbi.nlm.nih.gov/14515269/
IMMUNITY	Immune receptor	lectins	Pentraxins	Pentraxins	Pentaxin_CS	IPR030476	IPR001759					Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Immune receptor	lectins	Ricin-type lectins	R-type lectins	Ricin_B_lectin	IPR000772						Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Immune receptor	lectins	SUEL lectins	SUEL lectin	Lectin_gal-bd_dom	IPR000922						Gerdol 2017	10.25431/1824-307X/isj.v14i1.103-118	https://www.isj.unimore.it/index.php/ISJ/article/view/29/332
IMMUNITY	Immune receptor	lectins	VIgL _C-type lectin-related protein	CREP	"CTLD, Ig-like"	"IPR001304,IPR007110"	"IPR001304,IPR036179"		"IPR003961,IPR036116"			Dheilly et al. 2015	10.1016/j.dci.2014.10.009	https://www.sciencedirect.com/science/article/pii/S0145305X14002560
IMMUNITY	Immune receptor	lectins	VIgL _Galectin-related protein	GREP	"Galectin, Ig-like"	"IPR001079,IPR007110"	"IPR001079,IPR036179"					Dheilly et al. 2015	10.1016/j.dci.2014.10.009	https://www.sciencedirect.com/science/article/pii/S0145305X14002560
IMMUNITY	Immune receptor	lectins	VIgL_fibrinogen-related proteins	FREP	"Fibrinogen_a/b/g_C_dom, Ig-like"	"IPR002181,IPR007110"	"IPR002181,IPR036179"					Dheilly et al. 2015	10.1016/j.dci.2014.10.009	https://www.sciencedirect.com/science/article/pii/S0145305X14002560
IMMUNITY	Immune receptor	lectins	_-mannosidase-like protein	M-type lectin	Glyco_hydro_47	IPR001382						Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
IMMUNITY	Immune receptor	LRR-domain containing protein	Leucine rich repeat containg protein	LRR-other	LRR	IPR001611	IPR032675		"IPR007110,IPR007111,IPR000157"			Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	LRR-domain containing protein	Leucine rich repeate and immunoglobin domain containing protein	LRR-IG	"LRR, Ig"	"IPR001611,IPR007110"						Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	PRRs	2'-5'-oligoadenylate synthetase	OAS	" 2-5-oligoAdlate_synth_1_dom2/C, NT_2-5OAS_ClassI-CCAase, Polymerase_NTP_transf_dom"	"IPR018952,IPR006116,IPR002934"				"P00973,P29728,Q9Y6K5"		Lamers et al. 2019	10.3389/fimmu.2019.01763	https://www.frontiersin.org/articles/10.3389/fimmu.2019.01763/full
IMMUNITY	Immune receptor	PRRs	ATP-binding cassette sub-family F member-like	ABCF1	"AAA+_ATPase,ABC_transporter-like_ATP-bd"	"IPR003593,IPR003439"				Q8NE71		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
IMMUNITY	Immune receptor	PRRs	ATP-dependent DNA helicase II/X-ray repair cross-complementing protein 5/6	Ku70/80	"Ku70/Ku80_beta-barrel_dom,Ku_C,Ku_N"	"IPR006164,IPR005160,IPR005161"				"P12956,P13010"	Q9I7M8	"Goubau et al. 2013,Paludan and Bowie 2013"	"10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004"	"https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X"
IMMUNITY	Immune receptor	PRRs	"Beta 1,3-glucan recognition proteins"	GRP	BGBP_N	IPR031756					Q9NHB0	Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	PRRs	CD36/scavenger receptor class B member 1-like	CD36-like	CD36/SCARB1/SNMP1	IPR005428	IPR002159			Q8WTV0		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	PRRs	Cyclic GMP-AMP synthase	cGAS	Mab-21_dom	IPR024810				P78527		"Goubau et al. 2013,Paludan and Bowie 2013"	"10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004"	"https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X"
IMMUNITY	Immune receptor	PRRs	DNA repair protein RAD50	RAD50	"Rad50/SbcC_AAA,ABC_Rad50,Zn_hook_RAD50"	"IPR038729,IPR045171,IPR013134"	"IPR027417,IPR004584"			Q92878		"Goubau et al. 2013,Paludan and Bowie 2013"	"10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004"	"https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X"
IMMUNITY	Immune receptor	PRRs	DNA-dependent protein kinase-like	DNAPK	"DNA-PK_dom, DNAPKcs_CC5,DNAPKcs_CC3"	"IPR037706,IPR045581,IPR012582"	IPR037706			P78527		"Goubau et al. 2013,Paludan and Bowie 2013"	"10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004"	"https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X"
IMMUNITY	Immune receptor	PRRs	DNA-directed RNA polymerase III 	RNApol_III	"RNA_pol_Rpc34,WH_DNA-bd_sf"	"IPR007832,IPR036390"	"IPR016049,IPR036388"			Q9H1D9		"Goubau et al. 2013,Paludan and Bowie 2013"	"10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004"	"https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X"
IMMUNITY	Immune receptor	PRRs	Double-strand break repair protein MRE11-like	MRE11	"Mre11_N,Mre11_DNA-bd"	"IPR041796,IPR007281"	"IPR038487,IPR004843"			P49959		"Goubau et al. 2013,Paludan and Bowie 2013"	"10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004"	"https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X"
IMMUNITY	Immune receptor	PRRs	EIF2AK2/PKR-like	PKR	"EIF2AK2_DSRM_1,EIF2AK2_DSRM_2,Prot_kinase_dom"	"IPR044452,IPR044453,IPR000719"	"IPR014720,IPR000719"			P19525		Lamers et al. 2019	10.3389/fimmu.2019.01763	https://www.frontiersin.org/articles/10.3389/fimmu.2019.01763/full
IMMUNITY	Immune receptor	PRRs	Gram-negative bacteria binding-protein	GNBP	GH16	IPR000757					Q9NHB0	Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	PRRs	High mobility group box proteins	HMGBs	HMG_box_dom	IPR009071	IPR036910			"P09429,P26583,O15347"		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
IMMUNITY	Immune receptor	PRRs	Interferon-inducible proteins	AIM2-like/IFI16-like	"DAPIN, HIN200/IF120x"	"IPR004020,IPR004021"	"IPR011029,IPR004021"			"O14862,Q16666"		"Goubau et al. 2013,Paludan and Bowie 2013"	"10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004"	"https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X"
IMMUNITY	Immune receptor	PRRs	Leucine-rich repeat flightless-interacting protein 1-like	LRRFIP1	LRRFIP1/2	IPR019139				Q32MZ4		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
IMMUNITY	Immune receptor	PRRs	Monocyte differentiation antigen CD14	CD14	Monocyte_diff_Ag_CD14	IPR016337				P08571		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
IMMUNITY	Immune receptor	PRRs	Myeloid Differentiation factor 2/Lymphocyte antigen 96	MD2	ML_dom	IPR003172	IPR039217			Q9Y6Y9		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
IMMUNITY	Immune receptor	PRRs	NOD-like receptor	NLR	"NACHT, LRR"	"IPR007111,IPR001611"	"IPR007111,IPR032675"			"Q9Y239,Q9HC29,Q7RTR2,Q86WI3,Q86UT6,Q7RTR0,Q86W26,Q8WX94"		Wicherska-Pawowska et al. 2021	10.3390/ijms222413397	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704656/
IMMUNITY	Immune receptor	PRRs	peptidoglycan recognition proteins	PGRP	PGRP_domain_met/bac	IPR006619				O75594		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	PRRs	RIG-I-like receptors	RLR	"RIG-I_C,RLR_CTR"	"IPR011545,IPR041204,IPR021673"	IPR038557			"O95786,Q9BYX4,Q96C10"		Wicherska-Pawowska et al. 2021	10.3390/ijms222413397	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704656/
IMMUNITY	Immune receptor	PRRs	scavenger receptor cysteine-rich domain containing protein	SRCR	SRCR	IPR001190				"Q4G0T1,Q8WTU2,A1L4H1"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
IMMUNITY	Immune receptor	PRRs	Stimulator of interferon genes 	STING/MITA	STING_C	IPR033952	IPR038623			Q86WV6		"Goubau et al. 2013,Paludan and Bowie 2013"	"10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004"	"https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X"
IMMUNITY	Immune receptor	PRRs	Toll-like receptor	TLR	"TIR, LRR"	"IPR000157,IPR001611"	"IPR000157,IPR032675"	"IPR000157,IPR003591"		"Q15399,O60603,O15455,O00206,O60602,Q9Y2C9,Q9NYK1,Q9NR97,Q9NR96,Q9BXR5"		Wicherska-Pawowska et al. 2021	10.3390/ijms222413397	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8704656/
IMMUNITY	Immune receptor	PRRs	Z-DNA-binding proteins	ZBP/DAI	Z_dom	IPR042371				Q9H171		Paludan and Bowie 2013	10.1016/j.immuni.2013.05.004	https://www.sciencedirect.com/science/article/pii/S107476131300201X
REGULATORY PATHWAYS	Intracellular signal transduction	Apoptosis	Apoptosis regulator Bcl2- like	Bcl2-like	"Bcl-2_BH1-3,Bcl2_BH4"	"IPR026304,IPR003093"	IPR002475			Q07817		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
REGULATORY PATHWAYS	Intracellular signal transduction	Apoptosis	Caspases	Caspase	Pept_C14A	IPR015917				"P29466,P42575,P42574,P49662,P51878,P55212,P55210,Q14790,P55211,Q92851"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
REGULATORY PATHWAYS	Intracellular signal transduction	Apoptosis	Fas apoptotic inhibitory molecule 	FAIM	FAIM1_dom_sf	IPR038513	IPR010695			Q9NVQ4		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
REGULATORY PATHWAYS	Intracellular signal transduction	Apoptosis	Mitochondrial apoptosis-inducing factor	AIF	"AIF_C,FAD/NAD-binding_dom"	"IPR029324,IPR023753"	"IPR029324,IPR036188"			O95831		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
REGULATORY PATHWAYS	Intracellular signal transduction	Apoptosis	Serine protease HTRA2	HTRA2	"PDZ,PDZ_6,Peptidase_S1C"	"IPR041489,IPR001478,IPR001940"				O43464		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	Baculoviral IAP repeat-containing proteins	IAPs	BIR_rpt	IPR001370				"Q13490,Q13489"		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	E3 ubiquitin ligase Pellino	Pellino	Pellino_fam	IPR006800				"Q96FA3,Q9HAT8,Q8N2H9"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	E3 ubiquitin-protein ligase RNF135/RING finger protein leading to RIG-I activation	RNF134/RIPLET	"RNF135_SPRY_PRY_dom,Znf_RING"	"IPR042723,IPR001841"	"IPR001870,IPR001841"			Q8IUD6		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	E3 ubiquitin-protein ligase RNF31	HOIP	"IBR,BUP,RNF31-UBA,RNF31_C,TRIAD_supradom,Znf_RanBP2"	"IPR002867,IPR018997,IPR032065,IPR041031,IPR044066,IPR001876"	"IPR032065,IPR001841,IPR036443,IPR044066,IPR018997"			Q96EP0		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	E3 ubiquitin-protein ligase TRIM	TRIM	"Znf_B-box,Znf_RING"	"IPR000315,IPR001841"				Q9BZY9		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	E3 ubiquitin-protein ligase TRIM23	ARD1	"Bbox_C,Small_GTP-bd_dom,Znf-RING_LisH,Znf_B-box,Znf_C2H2_type"	"IPR003649,IPR005225,IPR027370,IPR000315,IPR013087"	"IPR024156,IPR013083,IPR036236"			P36406		Sparrer et al. 2017	10.1038/s41564-017-0017-2	https://pubmed.ncbi.nlm.nih.gov/28871090/
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	E3 ubiquitin-protein ligase TRIM31	TRIM4	"PRY/SPRY_TRIM4, Znf_B-box,Znf_RING"	"IPR035829,IPR000315,IPR001841"	"IPR001870,IPR000315,IPR001841"			Q9C037		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	E3 ubiquitin/ISG15 ligase TRIM25/65	TRIM25/65	"B30.2/SPRY,SPRY,Znf_RING"	"IPR001870,IPR003877,IPR001841"	"IPR013320,IPR043136,IPR013083"			"Q14258,Q6PJ69"		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	RanBP-type and C3HC4-type zinc finger-containing protein 1 RBCK1	HOIL1	"TRIAD,Ubiquitin-like_dom,Znf-RING_LisH,Znf_RanBP2"	"IPR044066,IPR000626,IPR027370,IPR001876"	"IPR026261,IPR001841,IPR036443"			Q9BYM8		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	RNA-binding E3 ubiquitin-protein ligase MEX3C	MEX3C	"KH_dom_type_1,Znf_RING"	"IPR004088,IPR001841"	"IPR036612,IPR013083"			Q5U5Q3		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	Sharpin	SHARPIN	"Sharpin_PH,Znf_RanBP2,Ubiquitin-like_domsf"	"IPR031912,IPR001876,IPR029071"	"IPR026261,IPR000626,IPR036443"		IPR044066	Q9H0F6		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	Suppressor of cytokine signaling	SOCS	"SOCS2_SH2,SOCS_box"	"IPR035862,IPR001496"	"IPR036036,IPR000980"			"O15524,O14508"		Green and Speck 2018	10.3390/v10030133	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/
REGULATORY PATHWAYS	Intracellular signal transduction	E3 Ubiquitin ligases	TNF receptor-associated factors	TRAF	"Znf_TRAF,MATH/TRAF_dom,Znf_RING"	"IPR001293,IPR002083,IPR001841"	"IPR043211,IPR001293,IPR001841"			"Q13077,Q12933,Q13114,Q9BUZ4,O00463,Q9Y4K3,Q6Q0C0"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	Integrated stress response	"DNA damage-inducible transcript 3 protein (CHOP, c/EBPz/GADD153)"	DDIT3/CHOP	"bZIP,DNA_damage_induc_transcript_3"	"IPR004827,IPR016670"				P35638		Park et al. 2010	10.1074/jbc.M110.136259	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975157/
REGULATORY PATHWAYS	Intracellular signal transduction	"Interleukins, Cytokines and Hematopoietins"	Granulins	Granulins	Granulin	IPR000118	IPR037277			P28799		Buddenbor et al. 2017	10.1371/journal.pntd.0005984	https://www.ncbi.nlm.nih.gov/pubmed/29045404
REGULATORY PATHWAYS	Intracellular signal transduction	"Interleukins, Cytokines and Hematopoietins"	Interferon alpha/beta receptor	IFNAR	"FN3_dom,Interferon/interleukin_rcp_dom"	"IPR003961,IPR015373"	"IPR013783,IPR015374"			"P17181,P48551"		Paludan and Bowie 2013	10.1016/j.immuni.2013.05.004	https://www.sciencedirect.com/science/article/pii/S107476131300201X
REGULATORY PATHWAYS	Intracellular signal transduction	"Interleukins, Cytokines and Hematopoietins"	Interleukin 17	IL-17	"IL-17_fam,Cystine-knot_cytokine"	"IPR010345,IPR029034"				"Q16552,Q9NRM6,Q9P0M4,Q8TAD2"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	"Interleukins, Cytokines and Hematopoietins"	Interleukin 17 receptor	IL17R	"SEFIR_dom,IL-17_rcpt-like"	"IPR013568,IPR039465"	IPR013568			"Q96F46,Q9NRM6,Q8NAC3,Q8NFM7"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	"Interleukins, Cytokines and Hematopoietins"	Macrophage migration inhibitory factor	MIF	Macrophage_inhib_fac_CS	IPR019829	IPR001398			P14174		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	JAK/STAT	Signal transducer and activator of transcription	STAT	"SH2,STAT_TF_alpha,STAT_TF_DNA-bd,STAT_TF_prot_interaction"	"IPR000980,IPR013800,IPR013801,IPR013799"	"IPR013801,IPR001217"			"P42224,P52630,P40763"		Green and Speck 2018	10.3390/v10030133	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/
REGULATORY PATHWAYS	Intracellular signal transduction	JAK/STAT	Tyrosine-protein kinase JAK	JAK	"Ser-Thr/Tyr_kinase_cat_dom,JAK1-3/TYK2_PHL_dom,FERM_F1,FERM_F2"	"IPR001245,IPR041381,IPR041155,IPR041046"	"IPR000719,IPR000299"			"P23458,O60674,P52333"		Green and Speck 2018	10.3390/v10030133	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869526/
REGULATORY PATHWAYS	Intracellular signal transduction	MAVS pathway	Mitochondrial Antiviral-Signaling Protein	MAVS	"CARD_IPS1, Mt_antiviral_sig_pro_met"	"IPR042144,IPR026148"	"IPR031964,IPR026148"			Q7Z434		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Activating protein 1 family	AP-1	"AP-1,bZIP"	"IPR000837,IPR004827"				"P05412,P01100,Q8WYK2,P15336,P18847"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Activating protein 1 JUN	JUN	"Leuzip_Jun, Bzip"	"IPR002112,IPR004827"
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Apoptosis signal-regulating kinase (MAP3Ks)	ASK	"MAP3K_PH, MAP3K_TRAF-bd,Prot_kinase_dom"	"IPR043969,IPR025136,IPR000719"				Q99683		Huang et al. 2009	0.1016/j.cyto.2009.08.002	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Dual specificity mitogen-activated protein kinase kinase	MAP2Ks	"Prot_kinase_dom,Ser/Thr_kinase_AS"	"IPR000719,IPR008271"				"Q02750,P36507,P46734,P45985,Q13163,P52564,O14733"		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Dual specificity mitogen-activated protein kinase kinase kinase	MAP3Ks	"Prot_kinase_dom,Ser/Thr_kinase_AS"	"IPR000719,IPR008271"				"Q6ZN16,Q13233,Q9Y2U5,Q99759,Q9Y6R4,Q99683,O95382,O43318,P41279,P80192,Q02779,Q16584,Q12852,O43283,Q99558"		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Extracellularly Regulated Kinase 1/2	ERK1/2	"ERK1/2,Prot_kinase_dom"	"IPR008349,IPR000719"				"P27361,P28482"		Huang et al. 2009	0.1016/j.cyto.2009.08.002	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Extracellularly Regulated Kinase 3/4	ERK3/4	"ERK3/4,Prot_kinase_dom"	"IPR008350,IPR000719"				"Q16659,P31152"		Huang et al. 2009	0.1016/j.cyto.2009.08.002	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Inhibitor of NFkB	IkB	Ankyrin_rpt	IPR002110	"IPR038753,IPR036770"			"P25963,Q15653,Q8NI38"	"Q03017,Q9VEZ5"	Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Inhibitor of nuclear factor kappa-B kinase subunit alpha	IKK	"IKBKB_SDD,Prot_kinase_dom"	"IPR041185,IPR000719"				O15111		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	IKKe/i	"Prot_kinase_dom,TBK1_CCD1,TBK1_ULD"	"IPR000719,IPR041309,IPR041087"				Q14164		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Interferon regulatory factor	IRF	Interferon_reg_fact_DNA-bd_dom	IPR001346				"P10914,P14316,Q14653,Q15306,Q13568,O14896,P10914,Q02556,Q00978"		Goubau et al. 2013	10.1016/j.immuni.2013.05.007	https://www.sciencedirect.com/science/article/pii/S1074761313002045
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Interleukin-1 receptor-associated kinase 1	IRAK	"Death_IRAK1,Prot_kinase_dom"	"IPR035533,IPR000719"	"IPR011029,IPR000719"			"P51617,O43187,Q9Y616,Q9NWZ3"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Major Vault Protein	MVP	"MVP_rep_dom,MVP_shoulder"	"IPR041139,IPR021870"	"IPR043023,IPR036013"			Q14764		Wang et al. 2020	10.1002/iub.2200	https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.2200
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	MAP kinase-activated protein kinase 2	MK2	"MAPKAPK_C,Prot_kinase_dom,Ser/Thr_kinase_AS"	"IPR027442,IPR000719,IPR008271"				P49137		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	MAP3K7/TGF-beta-activated kinase 1	TAK1	"MAPKKK7,Prot_kinase_dom,Ser-Thr/Tyr_kinase_cat_dom"	"IPR017421,IPR001245,IPR000719"				O43318		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	"Mitogen activated protein kinase kinase kinase 10 (MST, MLK2)"	MAP3K10	"MAP3K10,Prot_kinase_dom"	"IPR015785,IPR000719"				Q02779		Huang et al. 2009	0.1016/j.cyto.2009.08.002	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	"Mitogen activated protein kinase kinase kinase 12/13 (DLK, MEKK12/13)"	MAP3K12/13	"MAP3K12/13,Prot_kinase_dom"	"IPR017419,IPR000719"				"Q12852,O43283"		Huang et al. 2009	0.1016/j.cyto.2009.08.002	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Mitogen activated protein kinase kinase kinase 2/3	MAP3K1/2	"PB1_MEKK2/3,Prot_kinase_dom"	"IPR034879,IPR000719"				"Q13233,Q9Y2U5"		Huang et al. 2009	0.1016/j.cyto.2009.08.002	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	"Mitogen activated protein kinase kinase kinase 4 (MEKK4, MTK1)"	MAP3K4	"MAP3K4,Prot_kinase_dom"	"IPR045801,IPR000719"				Q9Y6R4		Huang et al. 2009	0.1016/j.cyto.2009.08.002	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Mitogen activated protein kinase phosphatase	MKP	MKP	IPR008343				Q13115		Huang et al. 2009	0.1016/j.cyto.2009.08.002	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Mitogen activated protein kinases	MAPKs	"MAP_kinase_CS,Prot_kinase_dom"	"IPR003527,IPR000719"				"P28482,P27361,Q16659,P31152,Q16539,P53778,P45983,Q15759,P45984"		Xie 2013	10.1186/1750-2187-8-7	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Mitogen-activated protein kinase 8	JNK	"MAP_kinase_CS,Prot_kinase_dom,MAPK_JNK"	"IPR003527,IPR000719,IPR008351"				P45983		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Mitogen-activated protein kinase kinase 5 (MEK5)	MAP2K5	"PB1_MAP2K5,Prot_kinase_dom"	"IPR034851,IPR000719"				Q13163		Huang et al. 2009	0.1016/j.cyto.2009.08.002	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782697/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Mitogen-activated protein kinase kinase kinase 8	TPL2/MAP3K8	"Prot_kinase_dom,Ser/Thr_kinase_AS,Kinase-like_dom_sf,MAPKKK8"	"IPR000719,IPR008271,IPR017424"	IPR017424			P41279		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Nck-associated_protein-1	NAP1	Nck-associated_protein-1	IPR019137				Q9Y2A7		Xie 2013	10.1186/1750-2187-8-7	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	NF-kappa-B essential modulator	IKKg/NEMO	"NEMO_ZF,CC2-LZ_dom"	"IPR034735,IPR032419"	"IPR032419,IPR034735"			Q9Y6K9		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Nuclear factor kB	NFkB	"IPT_NFkappaB, RHD_DNA_bind_dom"	"IPR033926,IPR011539"	"IPR032397,IPR011539"			"P19838,Q00653,Q04206,Q01201"		"Goubau et al. 2013,Paludan and Bowie 2013"	"10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004"	"https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X"
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	p38 MAPK/ MAPK14	p38	"Prot_kinase_dom,MAPK_p38-like"	"IPR008352,IPR000719"				Q16539		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	Receptor-interacting serine/threonine-protein kinase	RIPKs	"RIP1_Death,RHIM_dom,Ser-Thr/Tyr_kinase_cat_dom"	"IPR037934,IPR025735,IPR001245"	"IPR011029,IPR025735,IPR000719"			"Q13546,O43353,Q9Y572,P57078"		Newton 2015	10.1016/j.tcb.2015.01.001	https://www.sciencedirect.com/science/article/pii/S0962892415000124
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	RIG-I and MAVS type CARD domain containing proteins	RIGI/IPS1_CARD_DC	CARD_dom	IPR031964
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	RIO Kinase 3	RIOK3	RIO_kinase	"IPR000687,IPR017406"				O14730		Feng et al. 2014	10.1128/JVI.00643-14	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097797/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	TANK-binding kinase 1-binding protein 1	TBKBP1/SINTBAD	"CALCOCO1/2_Zn_UBZ1,TBD"	"IPR041641,IPR024581"	IPR024581			A7MCY6		Xie 2013	10.1186/1750-2187-8-7	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	TANK-binding kinase 1/ NFkB activated Kinase	TBK1/NAK	"TBK1_ULD, TBK1_CCD1, Prot_kinase_dom"	"IPR041087,IPR041309,IPR000719"				Q9UHD2		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1	TAB1	PPM-type_phosphatase_dom	IPR001932				Q15750		Xie 2013	10.1186/1750-2187-8-7	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/
REGULATORY PATHWAYS	Intracellular signal transduction	NFkB/IRF pathway	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2/3	TAB2/3	"TAB2/3_CUE,Znf_RanBP2"	"IPR041911,IPR001876"	"IPR003892,IPR036443"			"Q9NYJ8,Q8N5C8"		Xie 2013	10.1186/1750-2187-8-7	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/
REGULATORY PATHWAYS	Intracellular signal transduction	Other signaling	A disintegrin and metalloproteinase 	ADAM	Peptidase_M12B	IPR001590				"P78536,O14672,P78325"		Buddenbor et al. 2017	10.1371/journal.pntd.0005984	https://www.ncbi.nlm.nih.gov/pubmed/29045404
REGULATORY PATHWAYS	Intracellular signal transduction	Other signaling	Catenin beta	b-Catenin	Beta-catenin	IPR013284				P35222		"Goubau et al. 2013,Paludan and Bowie 2013"	"10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004"	"https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X"
REGULATORY PATHWAYS	Intracellular signal transduction	Other signaling	GTPase IMAP family member	GIMAP	G_AIG1	IPR006703				"Q8WWP7,Q9UG22,Q9NUV9,Q96F15,Q6P9H5,Q8NHV1,Q8ND71"		Buddenbor et al. 2017	10.1371/journal.pntd.0005984	https://www.ncbi.nlm.nih.gov/pubmed/29045404
REGULATORY PATHWAYS	Intracellular signal transduction	Other signaling	RanBP2 domain containing proteins	RanBP2DC	Znf_RanBP2	IPR001876	IPR036443					Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	Other signaling	sialate O-acetylesterase	SIAE	SASA	IPR005181	IPR039329			Q9HAT2		Buddenbor et al. 2017	10.1371/journal.pntd.0005984	https://www.ncbi.nlm.nih.gov/pubmed/29045404
REGULATORY PATHWAYS	Intracellular signal transduction	Other signaling	Tyrosine-protein kinase Fyn	FYN	"Fyn/Yrk_SH3,Ser-Thr/Tyr_kinase_cat_dom"	"IPR035750,IPR001245"				P06241		Huang et al. 2000	10.1073/pnas.97.20.10923	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27125/
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	Armadillo fold and TIR domain containing proteins	ARM-TIR	"TIR, ARM"	"IPR000157,IPR000225"	"IPR035897,IPR016024"					Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	Epidermal growth factor and TIR domain containing proteins	EGF-TIR	"TIR, EGF-like_dom"	"IPR000157,IPR000742"						Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	Evolutionarily conserved signaling intermediate in Toll pathway	ECSIT	ECIST_C	IPR029342	IPR010418			Q9BQ95		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	Imunoglobulin and TIR domain containing proteins	IG-TIR	"TIR, Ig-like_dom"	"IPR000157,IPR007110"						Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	Myeloid differentiation primary response protein	MyD88	"TIR,Death_domain"	"IPR000157,IPR000488"				Q99836		"Goubau et al. 2013,Paludan and Bowie 2013"	"10.1016/j.immuni.2013.05.007,10.1016/j.immuni.2013.05.004"	"https://www.sciencedirect.com/science/article/pii/S1074761313002045.,https://www.sciencedirect.com/science/article/pii/S107476131300201X"
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	NAD(+) hydrolase SARM1	SARM	"TIR, SAM"	"IPR000157,IPR001660"				Q6SZW1		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	Orphan TIR proteins	OrTIR	TIR	IPR000157			"IPR006911,IPR001660,IPR007110,IPR001440,IPR000742,IPR000488,IPR017281,IPR032675"			Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	TIR and tetratrico peptide repeat containing proteins	TIR-TPR	"TIR, TPR_1"	"IPR000157,IPR001440"						Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	TIR domain-containing adapter molecule 1	TRIF/TICAM1	"RHIM,TIR,TRIF_N"	"IPR025735,IPR000157,IPR040886"	IPR017278			Q8IUC6		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	TIR domain-containing adapter molecule 2	TRAM/TICAM2	"Emp24-like,TIR"	"IPR015720,IPR000157"	"IPR015720,IPR035897"			Q86XR7		Manes and Nita-Lazar 2021	10.1128/mSystems.00336-21	https://journals.asm.org/doi/full/10.1128/mSystems.00336-21
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	Toll-interacting protein	TOLLIP	"TOLIP_CUE,Tollip_C2"	"IPR041799,IPR037301"	"IPR003892,IPR035892"			Q9H0E2		Green et al. 2015	10.1099/jgv.0.000244	https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.000244#tab2
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	Toll/interleukin-1 receptor domain-containing adapter protein	TIRAP/Mal	"Tol-interleuk_rcpt_adapt_Tirap,TIR"	"IPR017279,IPR000157"				P58753		Xie 2013	10.1186/1750-2187-8-7	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/
REGULATORY PATHWAYS	Intracellular signal transduction	TLR adaptor moleculues	TRAF family member-associated NF-kappa-B activator	TANK	"CALCOCO1/2_Zn_UBZ1,TBD,TANK"	"IPR041641,IPR024581,IPR039669"				Q92844		Xie 2013	10.1186/1750-2187-8-7	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697994/
REGULATORY PATHWAYS	Intracellular signal transduction	TNF pathway	Caspase and RIP adapter with death domain	CRADD	"CARD_RAIDD,CRADD_Death"	"IPR042148,IPR037926"	"IPR001315,IPR000488"			P78560		Hibino et al. 2006	10.1016/j.ydbio.2006.08.065	https://www.sciencedirect.com/science/article/pii/S0012160606011572?via%3Dihub
REGULATORY PATHWAYS	Intracellular signal transduction	TNF pathway	FAS-associated death domain protein	FADD	"DED_dom,Death_domain"	"IPR001875,IPR000488"	IPR016729			Q13158		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	TNF pathway	Lipopolysaccharide-induced tumor necrosis factor-alpha factor	LITAF	LITAF	IPR006629				Q99732		Seppala et al. 2021	10.1186/s12864-021-07428-1	https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-021-07428-1
REGULATORY PATHWAYS	Intracellular signal transduction	TNF pathway	Tumor necrosis factor	TNF	TNF_dom	IPR006052				P01375		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/
REGULATORY PATHWAYS	Intracellular signal transduction	TNF pathway	Tumor necrosis factor receptor type 1-associated DEATH domain protein	TRADD	"Death_domain,TRADD_N"	"IPR000488,IPR009095"	IPR035712			Q15628		Newton 2015	10.1016/j.tcb.2015.01.001	https://www.sciencedirect.com/science/article/pii/S0962892415000124
REGULATORY PATHWAYS	Intracellular signal transduction	TNF pathway	Tumore necrosis factor receptor	TNFR	TNFR/NGFR_Cys_rich_reg	IPR001368				"P19438,P20333,P36941"		Zhang et al. 2015	10.1038/srep08693	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346834/