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{"sheet":"annotations","index":0,"n_rows":418,"n_cols":6,"rows_kept":418}
[]
["Selected_pathway","Gene","GO_terms","Reactome_pathways","InterPro_descriptions","Signature_descriptions"]
["Activation of NF-kappaB in B cells","N67_000073","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit 3|26S proteasome regulatory subunit, C-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|Proteasome regulatory subunit C-terminal|PCI domain profile."]
["Activation of NF-kappaB in B cells","N67_000266","enzyme regulator activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 6|26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1","PCI domain|PCI domain profile.|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|26S proteasome subunit RPN7"]
["Activation of NF-kappaB in B cells","N67_000276","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA+ ATPase domain|ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|ATPase, AAA-type, conserved site|AAA ATPase, AAA+ lid domain|26S proteasome regulatory subunit P45-like","ATPase family associated with various cellular activities (AAA)|AAA|Proteasomal ATPase OB C-terminal domain|AAA-protein family signature.|AAA+ lid domain|26Sp45: 26S proteasome subunit P45 family"]
["Activation of NF-kappaB in B cells","N67_000509","peptidase activator activity|lysine-acetylated histone binding|proteasome binding"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator complex subunit 4 C-terminal domain|Proteasome activator complex subunit 4","Domain of unknown function (DUF3437)"]
["Activation of NF-kappaB in B cells","N67_000697","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome B-type subunit|Proteasome beta-type subunit, conserved site|Peptidase T1A, proteasome beta-subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|proteasome_beta_type_5|Proteasome beta-type subunit profile.|Proteasome beta-type subunits signature.|Proteasome component signature"]
["Activation of NF-kappaB in B cells","N67_000728","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA ATPase, AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA+ ATPase domain|ATPase, AAA-type, conserved site|ATPase, AAA-type, core|26S proteasome regulatory subunit P45-like","AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA|AAA-protein family signature.|ATPase family associated with various cellular activities (AAA)|26Sp45: 26S proteasome subunit P45 family"]
["Activation of NF-kappaB in B cells","N67_000908",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 13","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain"]
["Activation of NF-kappaB in B cells","N67_001466","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit beta 2|Proteasome beta-type subunit, conserved site|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome beta-type subunits signature.|proteasome_beta_type_2|Proteasome subunit"]
["Activation of NF-kappaB in B cells","N67_001507","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Hypusine synthesis from eIF5A-lysine| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S Proteasome non-ATPase regulatory subunit 1|26S proteasome regulatory subunit RPN2, C-terminal|Proteasome/cyclosome repeat|PBS lyase HEAT-like repeat|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit","26S proteasome regulatory subunit RPN2 C-terminal domain|Proteasome/cyclosome repeat|E-Z type HEAT repeats|HEAT repeats"]
["Activation of NF-kappaB in B cells","N67_001583","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha 1|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|proteasome_alpha_type_1"]
["Activation of NF-kappaB in B cells","N67_001700","ubiquitin-dependent protein catabolic process"," Activation of NF-kappaB in B cells| Prolactin receptor signaling| SCF-beta-TrCP mediated degradation of Emi1| Vpu mediated degradation of CD4| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| NOTCH1 Intracellular Domain Regulates Transcription| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| Circadian Clock| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| NIK-->noncanonical NF-kB signaling| MAP3K8 (TPL2)-dependent MAPK1/3 activation| Orc1 removal from chromatin| Cyclin D associated events in G1| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Regulation of RUNX2 expression and activity| Neddylation| Interleukin-1 signaling| Iron uptake and transport| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","SKP1 component, POZ domain|S-phase kinase-associated protein 1-like|S-phase kinase-associated protein 1|SKP1 component, dimerisation","Skp1 family, tetramerisation domain|BTB_POZ_SKP1|Skp1 family, dimerisation domain"]
["Activation of NF-kappaB in B cells","N67_001710","protein binding|metallopeptidase activity|Lys63-specific deubiquitinase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Metalloprotease DUBs| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","MPN domain|26S Proteasome non-ATPase regulatory subunit 14|JAB1/MPN/MOV34 metalloenzyme domain|Rpn11/EIF3F, C-terminal","MPN domain profile.|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN_RPN11_CSN5|Maintenance of mitochondrial structure and function"]
["Activation of NF-kappaB in B cells","N67_001726","threonine-type endopeptidase activity|proteasome core complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome subunit beta Pre3|Nucleophile aminohydrolases, N-terminal","Proteasome subunit"]
["Activation of NF-kappaB in B cells","N67_001963","threonine-type endopeptidase activity|proteasome core complex|proteolysis|HslUV protease complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATP-dependent protease, HslV subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome B-type subunit","ATP_dep_HslV: ATP-dependent protease HslVU, peptidase subunit|Proteasome subunit|Proteasome beta-type subunit profile.|protease_HslV"]
["Activation of NF-kappaB in B cells","N67_002329","ATP binding|cytoplasm|hydrolase activity|protein catabolic process|proteasome-activating ATPase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|26S proteasome regulatory subunit P45-like|ATPase, AAA-type, conserved site|AAA+ ATPase domain|AAA ATPase, AAA+ lid domain|26S Proteasome regulatory subunit 6B","ATPase family associated with various cellular activities (AAA)|Proteasomal ATPase OB C-terminal domain|26Sp45: 26S proteasome subunit P45 family|AAA|AAA-protein family signature.|AAA+ lid domain"]
["Activation of NF-kappaB in B cells","N67_002487","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteasome core complex, beta-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta 3 subunit|Proteasome beta-type subunit, conserved site","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_3|Proteasome beta-type subunits signature."]
["Activation of NF-kappaB in B cells","N67_002738","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha5|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit A N-terminal signature|Proteasome alpha-type subunits signature.|proteasome_alpha_type_5|Proteasome subunit|Proteasome alpha-type subunit profile."]
["Activation of NF-kappaB in B cells","N67_002863","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Proteasome subunit alpha2","proteasome_alpha_type_2|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|Proteasome subunit"]
["Activation of NF-kappaB in B cells","N67_002919",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit RPN5, C-terminal domain|26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4|Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 12|Winged helix-like DNA-binding domain superfamily","26S proteasome regulatory subunit RPN5 C-terminal domain|PCI domain profile.|PCI domain|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15"]
["Activation of NF-kappaB in B cells","N67_003190","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 7|Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Peptidase T1A, proteasome beta-subunit","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_7|Proteasome beta-type subunit profile.|Proteasome component signature"]
["Activation of NF-kappaB in B cells","N67_003578",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome regulatory subunit Rpn6, N-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|PCI domain profile.|26S proteasome regulatory subunit RPN6 N-terminal domain"]
["Activation of NF-kappaB in B cells","N67_003579","structural constituent of ribosome|protein binding|ribosome|translation"," Translesion synthesis by REV1| Recognition of DNA damage by PCNA-containing replication complex| Translesion Synthesis by POLH| Activation of NF-kappaB in B cells| ISG15 antiviral mechanism| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants| ER-Phagosome pathway| Downregulation of ERBB4 signaling| Spry regulation of FGF signaling| Downregulation of ERBB2:ERBB3 signaling| L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| Budding and maturation of HIV virion| NOD1/2 Signaling Pathway| TICAM1, RIP1-mediated IKK complex recruitment| DDX58/IFIH1-mediated induction of interferon-alpha/beta| APC/C:Cdc20 mediated degradation of Cyclin B| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Membrane binding and targetting of GAG proteins| Assembly Of The HIV Virion| APC-Cdc20 mediated degradation of Nek2A| SRP-dependent cotranslational protein targeting to membrane| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| EGFR downregulation| SCF(Skp2)-mediated degradation of p27/p21| Viral mRNA Translation| Degradation of beta-catenin by the destruction complex| TCF dependent signaling in response to WNT| Downstream TCR signaling| NRIF signals cell death from the nucleus| p75NTR recruits signalling complexes| NF-kB is activated and signals survival| Regulation of activated PAK-2p34 by proteasome mediated degradation| NOTCH1 Intracellular Domain Regulates Transcription| Activated NOTCH1 Transmits Signal to the Nucleus| Downregulation of TGF-beta receptor signaling| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)| Downregulation of SMAD2/3:SMAD4 transcriptional activity| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription| Selenocysteine synthesis| Separation of Sister Chromatids| Oxidative Stress Induced Senescence| Senescence-Associated Secretory Phenotype (SASP)| Oncogene Induced Senescence| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Stimuli-sensing channels| Constitutive Signaling by NOTCH1 HD Domain Mutants| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| NOTCH2 Activation and Transmission of Signal to the Nucleus| Regulation of innate immune responses to cytosolic DNA| Glycogen synthesis| Autodegradation of the E3 ubiquitin ligase COP1| Deactivation of the beta-catenin transactivating complex| Myoclonic epilepsy of Lafora| ABC-family proteins mediated transport| Circadian Clock| TAK1 activates NFkB by phosphorylation and activation of IKKs complex| activated TAK1 mediates p38 MAPK activation| JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Regulation of FZD by ubiquitination| PINK1-PRKN Mediated Mitophagy| N-glycan trimming in the ER and Calnexin/Calreticulin cycle| Regulation of TNFR1 signaling| TNFR1-induced NFkappaB signaling pathway| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Negative regulation of FGFR1 signaling| Negative regulation of FGFR2 signaling| Negative regulation of FGFR3 signaling| Negative regulation of FGFR4 signaling| Translesion synthesis by POLK| Translesion synthesis by POLI| Termination of translesion DNA synthesis| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| Negative regulation of MAPK pathway| Regulation of necroptotic cell death| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAP3K8 (TPL2)-dependent MAPK1/3 activation| HDR through Homologous Recombination (HRR)| MAPK6/MAPK4 signaling| UCH proteinases| Josephin domain DUBs| Ub-specific processing proteases| Ovarian tumor domain proteases| Metalloprotease DUBs| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks| Processing of DNA double-strand break ends| DNA Damage Recognition in GG-NER| Formation of Incision Complex in GG-NER| Gap-filling DNA repair synthesis and ligation in GG-NER| Dual Incision in GG-NER| Formation of TC-NER Pre-Incision Complex| Transcription-Coupled Nucleotide Excision Repair (TC-NER)| Dual incision in TC-NER| Gap-filling DNA repair synthesis and ligation in TC-NER| Fanconi Anemia Pathway| Major pathway of rRNA processing in the nucleolus and cytosol| Regulation of TP53 Activity through Phosphorylation| Regulation of TP53 Degradation| Regulation of TP53 Activity through Methylation| Negative regulation of MET activity| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| Cyclin D associated events in G1| G2/M Checkpoints| Stabilization of p53| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Ubiquitin-dependent degradation of Cyclin D| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Cargo recognition for clathrin-mediated endocytosis| Clathrin-mediated endocytosis| Downregulation of ERBB2 signaling| Synthesis of active ubiquitin: roles of E1 and E2 enzymes| E3 ubiquitin ligases ubiquitinate target proteins| InlB-mediated entry of Listeria monocytogenes into host cell| InlA-mediated entry of Listeria monocytogenes into host cells| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN localization| Regulation of PTEN stability and activity| Neddylation| ER Quality Control Compartment (ERQC)| Regulation of expression of SLITs and ROBOs| NOTCH3 Activation and Transmission of Signal to the Nucleus| TICAM1-dependent activation of IRF3/IRF7| TICAM1,TRAF6-dependent induction of TAK1 complex| Interleukin-1 signaling| Peroxisomal protein import| Regulation of signaling by CBL| Endosomal Sorting Complex Required For Transport (ESCRT)| Iron uptake and transport| Negative regulators of DDX58/IFIH1 signaling| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon| IRAK1 recruits IKK complex| IKK complex recruitment mediated by RIP1| IRAK2 mediated activation of TAK1 complex| TRAF6-mediated induction of TAK1 complex within TLR4 complex| Negative regulation of NOTCH4 signaling| Chaperone Mediated Autophagy| Late endosomal microautophagy| Alpha-protein kinase 1 signaling pathway| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)| Amyloid fiber formation| Antigen processing: Ubiquitination & Proteasome degradation","S27a-like superfamily|Ribosomal protein S27a|Ubiquitin-like domain","Ubl_ubiquitin_like|Ribosomal protein S27a|Ubiquitin family|Ubiquitin domain profile."]
["Activation of NF-kappaB in B cells","N67_003696","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core|AAA+ ATPase domain|ATPase, AAA-type, conserved site","26Sp45: 26S proteasome subunit P45 family|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA|AAA-protein family signature."]
["Activation of NF-kappaB in B cells","N67_004122","proteasome regulatory particle|proteolysis"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","CSN8/PSMD8/EIF3K|Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit Rpn12","CSN8/PSMD8/EIF3K family|PCI domain profile."]
["Activation of NF-kappaB in B cells","N67_004247","protein binding|proteasome regulatory particle"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S Proteasome non-ATPase regulatory subunit 7/8|JAB1/MPN/MOV34 metalloenzyme domain|MPN domain|Rpn11/EIF3F, C-terminal","MPN_RPN7_8|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN domain profile.|Maintenance of mitochondrial structure and function"]
["Activation of NF-kappaB in B cells","N67_004346","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 4","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_4"]
["Activation of NF-kappaB in B cells","N67_004467","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal","Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|Proteasome subunit|Proteasome subunit A N-terminal signature|proteasome_alpha_type_7"]
["Activation of NF-kappaB in B cells","N67_004468","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit|Proteasome subunit A N-terminal signature|Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|proteasome_alpha_type_4"]
["Activation of NF-kappaB in B cells","N67_004565","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha6|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit","proteasome_alpha_type_6|Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature"]
["Activation of NF-kappaB in B cells","N67_004752","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA+ ATPase domain|ATPase, AAA-type, conserved site|Proteasomal ATPase OB C-terminal domain|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core","26Sp45: 26S proteasome subunit P45 family|AAA-protein family signature.|Proteasomal ATPase OB C-terminal domain|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA"]
["Activation of NF-kappaB in B cells","N67_004822","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit|RPN1/RPN2, N-terminal|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1, C-terminal","RPN1/RPN2 N-terminal domain|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1 C-terminal"]
["Activation of NF-kappaB in B cells","N67_004943","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 1|Nucleophile aminohydrolases, N-terminal","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_1|Proteasome beta-type subunits signature."]
["Activation of NF-kappaB in B cells","N67_004957","protein binding|proteasome regulatory particle assembly"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","PDZ superfamily|Nas2, N-terminal|26S Proteasome non-ATPase regulatory subunit 9","Nas2 N_terminal domain"]
["Activation of NF-kappaB in B cells","N67_004966","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit alpha 3|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome subunit A N-terminal signature|Proteasome subunit"]
["Activation of NF-kappaB in B cells","N67_005012","proteasome activator complex"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator PA28|Proteasome activator PA28, C-terminal domain superfamily|Proteasome activator PA28, C-terminal domain","Proteasome activator pa28 beta subunit"]
["Vpu mediated degradation of CD4","N67_000073","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit 3|26S proteasome regulatory subunit, C-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|Proteasome regulatory subunit C-terminal|PCI domain profile."]
["Vpu mediated degradation of CD4","N67_000266","enzyme regulator activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 6|26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1","PCI domain|PCI domain profile.|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|26S proteasome subunit RPN7"]
["Vpu mediated degradation of CD4","N67_000276","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA+ ATPase domain|ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|ATPase, AAA-type, conserved site|AAA ATPase, AAA+ lid domain|26S proteasome regulatory subunit P45-like","ATPase family associated with various cellular activities (AAA)|AAA|Proteasomal ATPase OB C-terminal domain|AAA-protein family signature.|AAA+ lid domain|26Sp45: 26S proteasome subunit P45 family"]
["Vpu mediated degradation of CD4","N67_000509","peptidase activator activity|lysine-acetylated histone binding|proteasome binding"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator complex subunit 4 C-terminal domain|Proteasome activator complex subunit 4","Domain of unknown function (DUF3437)"]
["Vpu mediated degradation of CD4","N67_000697","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome B-type subunit|Proteasome beta-type subunit, conserved site|Peptidase T1A, proteasome beta-subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|proteasome_beta_type_5|Proteasome beta-type subunit profile.|Proteasome beta-type subunits signature.|Proteasome component signature"]
["Vpu mediated degradation of CD4","N67_000728","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA ATPase, AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA+ ATPase domain|ATPase, AAA-type, conserved site|ATPase, AAA-type, core|26S proteasome regulatory subunit P45-like","AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA|AAA-protein family signature.|ATPase family associated with various cellular activities (AAA)|26Sp45: 26S proteasome subunit P45 family"]
["Vpu mediated degradation of CD4","N67_000908",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 13","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain"]
["Vpu mediated degradation of CD4","N67_001466","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit beta 2|Proteasome beta-type subunit, conserved site|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome beta-type subunits signature.|proteasome_beta_type_2|Proteasome subunit"]
["Vpu mediated degradation of CD4","N67_001507","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Hypusine synthesis from eIF5A-lysine| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S Proteasome non-ATPase regulatory subunit 1|26S proteasome regulatory subunit RPN2, C-terminal|Proteasome/cyclosome repeat|PBS lyase HEAT-like repeat|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit","26S proteasome regulatory subunit RPN2 C-terminal domain|Proteasome/cyclosome repeat|E-Z type HEAT repeats|HEAT repeats"]
["Vpu mediated degradation of CD4","N67_001583","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha 1|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|proteasome_alpha_type_1"]
["Vpu mediated degradation of CD4","N67_001700","ubiquitin-dependent protein catabolic process"," Activation of NF-kappaB in B cells| Prolactin receptor signaling| SCF-beta-TrCP mediated degradation of Emi1| Vpu mediated degradation of CD4| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| NOTCH1 Intracellular Domain Regulates Transcription| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| Circadian Clock| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| NIK-->noncanonical NF-kB signaling| MAP3K8 (TPL2)-dependent MAPK1/3 activation| Orc1 removal from chromatin| Cyclin D associated events in G1| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Regulation of RUNX2 expression and activity| Neddylation| Interleukin-1 signaling| Iron uptake and transport| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","SKP1 component, POZ domain|S-phase kinase-associated protein 1-like|S-phase kinase-associated protein 1|SKP1 component, dimerisation","Skp1 family, tetramerisation domain|BTB_POZ_SKP1|Skp1 family, dimerisation domain"]
["Vpu mediated degradation of CD4","N67_001710","protein binding|metallopeptidase activity|Lys63-specific deubiquitinase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Metalloprotease DUBs| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","MPN domain|26S Proteasome non-ATPase regulatory subunit 14|JAB1/MPN/MOV34 metalloenzyme domain|Rpn11/EIF3F, C-terminal","MPN domain profile.|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN_RPN11_CSN5|Maintenance of mitochondrial structure and function"]
["Vpu mediated degradation of CD4","N67_001726","threonine-type endopeptidase activity|proteasome core complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome subunit beta Pre3|Nucleophile aminohydrolases, N-terminal","Proteasome subunit"]
["Vpu mediated degradation of CD4","N67_001963","threonine-type endopeptidase activity|proteasome core complex|proteolysis|HslUV protease complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATP-dependent protease, HslV subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome B-type subunit","ATP_dep_HslV: ATP-dependent protease HslVU, peptidase subunit|Proteasome subunit|Proteasome beta-type subunit profile.|protease_HslV"]
["Vpu mediated degradation of CD4","N67_002329","ATP binding|cytoplasm|hydrolase activity|protein catabolic process|proteasome-activating ATPase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|26S proteasome regulatory subunit P45-like|ATPase, AAA-type, conserved site|AAA+ ATPase domain|AAA ATPase, AAA+ lid domain|26S Proteasome regulatory subunit 6B","ATPase family associated with various cellular activities (AAA)|Proteasomal ATPase OB C-terminal domain|26Sp45: 26S proteasome subunit P45 family|AAA|AAA-protein family signature.|AAA+ lid domain"]
["Vpu mediated degradation of CD4","N67_002487","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteasome core complex, beta-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta 3 subunit|Proteasome beta-type subunit, conserved site","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_3|Proteasome beta-type subunits signature."]
["Vpu mediated degradation of CD4","N67_002738","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha5|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit A N-terminal signature|Proteasome alpha-type subunits signature.|proteasome_alpha_type_5|Proteasome subunit|Proteasome alpha-type subunit profile."]
["Vpu mediated degradation of CD4","N67_002863","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Proteasome subunit alpha2","proteasome_alpha_type_2|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|Proteasome subunit"]
["Vpu mediated degradation of CD4","N67_002919",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit RPN5, C-terminal domain|26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4|Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 12|Winged helix-like DNA-binding domain superfamily","26S proteasome regulatory subunit RPN5 C-terminal domain|PCI domain profile.|PCI domain|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15"]
["Vpu mediated degradation of CD4","N67_003190","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 7|Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Peptidase T1A, proteasome beta-subunit","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_7|Proteasome beta-type subunit profile.|Proteasome component signature"]
["Vpu mediated degradation of CD4","N67_003578",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome regulatory subunit Rpn6, N-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|PCI domain profile.|26S proteasome regulatory subunit RPN6 N-terminal domain"]
["Vpu mediated degradation of CD4","N67_003579","structural constituent of ribosome|protein binding|ribosome|translation"," Translesion synthesis by REV1| Recognition of DNA damage by PCNA-containing replication complex| Translesion Synthesis by POLH| Activation of NF-kappaB in B cells| ISG15 antiviral mechanism| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants| ER-Phagosome pathway| Downregulation of ERBB4 signaling| Spry regulation of FGF signaling| Downregulation of ERBB2:ERBB3 signaling| L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| Budding and maturation of HIV virion| NOD1/2 Signaling Pathway| TICAM1, RIP1-mediated IKK complex recruitment| DDX58/IFIH1-mediated induction of interferon-alpha/beta| APC/C:Cdc20 mediated degradation of Cyclin B| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Membrane binding and targetting of GAG proteins| Assembly Of The HIV Virion| APC-Cdc20 mediated degradation of Nek2A| SRP-dependent cotranslational protein targeting to membrane| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| EGFR downregulation| SCF(Skp2)-mediated degradation of p27/p21| Viral mRNA Translation| Degradation of beta-catenin by the destruction complex| TCF dependent signaling in response to WNT| Downstream TCR signaling| NRIF signals cell death from the nucleus| p75NTR recruits signalling complexes| NF-kB is activated and signals survival| Regulation of activated PAK-2p34 by proteasome mediated degradation| NOTCH1 Intracellular Domain Regulates Transcription| Activated NOTCH1 Transmits Signal to the Nucleus| Downregulation of TGF-beta receptor signaling| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)| Downregulation of SMAD2/3:SMAD4 transcriptional activity| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription| Selenocysteine synthesis| Separation of Sister Chromatids| Oxidative Stress Induced Senescence| Senescence-Associated Secretory Phenotype (SASP)| Oncogene Induced Senescence| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Stimuli-sensing channels| Constitutive Signaling by NOTCH1 HD Domain Mutants| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| NOTCH2 Activation and Transmission of Signal to the Nucleus| Regulation of innate immune responses to cytosolic DNA| Glycogen synthesis| Autodegradation of the E3 ubiquitin ligase COP1| Deactivation of the beta-catenin transactivating complex| Myoclonic epilepsy of Lafora| ABC-family proteins mediated transport| Circadian Clock| TAK1 activates NFkB by phosphorylation and activation of IKKs complex| activated TAK1 mediates p38 MAPK activation| JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Regulation of FZD by ubiquitination| PINK1-PRKN Mediated Mitophagy| N-glycan trimming in the ER and Calnexin/Calreticulin cycle| Regulation of TNFR1 signaling| TNFR1-induced NFkappaB signaling pathway| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Negative regulation of FGFR1 signaling| Negative regulation of FGFR2 signaling| Negative regulation of FGFR3 signaling| Negative regulation of FGFR4 signaling| Translesion synthesis by POLK| Translesion synthesis by POLI| Termination of translesion DNA synthesis| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| Negative regulation of MAPK pathway| Regulation of necroptotic cell death| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAP3K8 (TPL2)-dependent MAPK1/3 activation| HDR through Homologous Recombination (HRR)| MAPK6/MAPK4 signaling| UCH proteinases| Josephin domain DUBs| Ub-specific processing proteases| Ovarian tumor domain proteases| Metalloprotease DUBs| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks| Processing of DNA double-strand break ends| DNA Damage Recognition in GG-NER| Formation of Incision Complex in GG-NER| Gap-filling DNA repair synthesis and ligation in GG-NER| Dual Incision in GG-NER| Formation of TC-NER Pre-Incision Complex| Transcription-Coupled Nucleotide Excision Repair (TC-NER)| Dual incision in TC-NER| Gap-filling DNA repair synthesis and ligation in TC-NER| Fanconi Anemia Pathway| Major pathway of rRNA processing in the nucleolus and cytosol| Regulation of TP53 Activity through Phosphorylation| Regulation of TP53 Degradation| Regulation of TP53 Activity through Methylation| Negative regulation of MET activity| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| Cyclin D associated events in G1| G2/M Checkpoints| Stabilization of p53| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Ubiquitin-dependent degradation of Cyclin D| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Cargo recognition for clathrin-mediated endocytosis| Clathrin-mediated endocytosis| Downregulation of ERBB2 signaling| Synthesis of active ubiquitin: roles of E1 and E2 enzymes| E3 ubiquitin ligases ubiquitinate target proteins| InlB-mediated entry of Listeria monocytogenes into host cell| InlA-mediated entry of Listeria monocytogenes into host cells| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN localization| Regulation of PTEN stability and activity| Neddylation| ER Quality Control Compartment (ERQC)| Regulation of expression of SLITs and ROBOs| NOTCH3 Activation and Transmission of Signal to the Nucleus| TICAM1-dependent activation of IRF3/IRF7| TICAM1,TRAF6-dependent induction of TAK1 complex| Interleukin-1 signaling| Peroxisomal protein import| Regulation of signaling by CBL| Endosomal Sorting Complex Required For Transport (ESCRT)| Iron uptake and transport| Negative regulators of DDX58/IFIH1 signaling| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon| IRAK1 recruits IKK complex| IKK complex recruitment mediated by RIP1| IRAK2 mediated activation of TAK1 complex| TRAF6-mediated induction of TAK1 complex within TLR4 complex| Negative regulation of NOTCH4 signaling| Chaperone Mediated Autophagy| Late endosomal microautophagy| Alpha-protein kinase 1 signaling pathway| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)| Amyloid fiber formation| Antigen processing: Ubiquitination & Proteasome degradation","S27a-like superfamily|Ribosomal protein S27a|Ubiquitin-like domain","Ubl_ubiquitin_like|Ribosomal protein S27a|Ubiquitin family|Ubiquitin domain profile."]
["Vpu mediated degradation of CD4","N67_003696","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core|AAA+ ATPase domain|ATPase, AAA-type, conserved site","26Sp45: 26S proteasome subunit P45 family|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA|AAA-protein family signature."]
["Vpu mediated degradation of CD4","N67_004122","proteasome regulatory particle|proteolysis"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","CSN8/PSMD8/EIF3K|Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit Rpn12","CSN8/PSMD8/EIF3K family|PCI domain profile."]
["Vpu mediated degradation of CD4","N67_004247","protein binding|proteasome regulatory particle"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S Proteasome non-ATPase regulatory subunit 7/8|JAB1/MPN/MOV34 metalloenzyme domain|MPN domain|Rpn11/EIF3F, C-terminal","MPN_RPN7_8|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN domain profile.|Maintenance of mitochondrial structure and function"]
["Vpu mediated degradation of CD4","N67_004346","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 4","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_4"]
["Vpu mediated degradation of CD4","N67_004467","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal","Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|Proteasome subunit|Proteasome subunit A N-terminal signature|proteasome_alpha_type_7"]
["Vpu mediated degradation of CD4","N67_004468","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit|Proteasome subunit A N-terminal signature|Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|proteasome_alpha_type_4"]
["Vpu mediated degradation of CD4","N67_004565","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha6|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit","proteasome_alpha_type_6|Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature"]
["Vpu mediated degradation of CD4","N67_004752","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA+ ATPase domain|ATPase, AAA-type, conserved site|Proteasomal ATPase OB C-terminal domain|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core","26Sp45: 26S proteasome subunit P45 family|AAA-protein family signature.|Proteasomal ATPase OB C-terminal domain|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA"]
["Vpu mediated degradation of CD4","N67_004822","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit|RPN1/RPN2, N-terminal|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1, C-terminal","RPN1/RPN2 N-terminal domain|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1 C-terminal"]
["Vpu mediated degradation of CD4","N67_004943","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 1|Nucleophile aminohydrolases, N-terminal","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_1|Proteasome beta-type subunits signature."]
["Vpu mediated degradation of CD4","N67_004957","protein binding|proteasome regulatory particle assembly"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","PDZ superfamily|Nas2, N-terminal|26S Proteasome non-ATPase regulatory subunit 9","Nas2 N_terminal domain"]
["Vpu mediated degradation of CD4","N67_004966","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit alpha 3|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome subunit A N-terminal signature|Proteasome subunit"]
["Vpu mediated degradation of CD4","N67_005012","proteasome activator complex"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator PA28|Proteasome activator PA28, C-terminal domain superfamily|Proteasome activator PA28, C-terminal domain","Proteasome activator pa28 beta subunit"]
["Viral mRNA Translation","N67_000074","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L2, domain 2|60S ribosomal protein L6E","Ribosomal protein L6e"]
["Viral mRNA Translation","N67_000098","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","60S ribosomal protein L18a/ L20, eukaryotes|50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a|Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A","50S ribosomal protein L18Ae [rpl18a].|Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A"]
["Viral mRNA Translation","N67_000099","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L18e/L15P|Ribosomal protein L18e|Ribosomal protein L18e, conserved site","Ribosomal protein 60S L18 and 50S L18e|Ribosomal protein L18e signature."]
["Viral mRNA Translation","N67_000105","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| mTORC1-mediated signalling| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| rRNA modification in the nucleus and cytosol| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S6e|Ribosomal protein S6e, conserved site","Ribosomal protein S6e|Ribosomal protein S6e signature."]
["Viral mRNA Translation","N67_000188","structural constituent of ribosome|ribosome|translation|large ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L22/L17|Ribosomal protein L22/L17, eukaryotic/archaeal|Ribosomal protein L22/L17 superfamily","Ribosomal protein L22p/L17e|uL22_arch_euk: ribosomal protein uL22|Ribosomal_L22|50S ribosomal protein L22 [rplV]."]
["Viral mRNA Translation","N67_000296","RNA binding|structural constituent of ribosome|ribosome|translation|large ribosomal subunit|transferase activity"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L2, domain 3|Ribosomal protein L2, domain 2|Ribosomal protein L2|Ribosomal protein L2, C-terminal|Ribosomal protein L2, bacterial/organellar-type|Ribosomal Proteins L2, RNA binding domain","rplB_bact: ribosomal protein uL2|Ribosomal Proteins L2, RNA binding domain|Ribosomal Proteins L2, C-terminal domain"]
["Viral mRNA Translation","N67_000338","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S14, conserved site|Ribosomal protein S14|Ribosomal protein S14/S29","Ribosomal protein S14 signature.|Ribosomal protein S14p/S29e"]
["Viral mRNA Translation","N67_000384","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L28e|Ribosomal L28e/Mak16","Ribosomal L28e protein family"]
["Viral mRNA Translation","N67_000385","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L35Ae, conserved site|Ribosomal protein L35A|Ribosomal protein L35A superfamily","Ribosomal protein L35Ae signature.|Ribosomal protein L35Ae|50S ribosomal protein L35Ae [rpl35ae]."]
["Viral mRNA Translation","N67_000399","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S21e|Ribosomal protein S21e superfamily","Ribosomal protein S21e"]
["Viral mRNA Translation","N67_000490","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L13e","50S ribosomal protein L13e [rpl13e].|Ribosomal protein L13e"]
["Viral mRNA Translation","N67_000642","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S3Ae|40S ribosomal protein S1/3, eukaryotes","Ribosomal S3Ae family|40S ribosomal protein S1 [RPS3A]."]
["Viral mRNA Translation","N67_000988","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S19e|Ribosomal protein S19e domain superfamily|Ribosomal protein S19e, conserved site","Ribosomal protein S19e|Ribosomal protein S19e signature."]
["Viral mRNA Translation","N67_001067","structural constituent of ribosome|ribosome|translational elongation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein P1/P2, N-terminal domain|Ribosomal protein L12 family","60s Acidic ribosomal protein|Ribosomal_P1|50S ribosomal protein L12 [rpl12]."]
["Viral mRNA Translation","N67_001085","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S4e|Ribosomal protein S4e, central domain superfamily|40S ribosomal protein S4, C-terminal domain|KOW|Ribosomal protein S4e, N-terminal|Ribosomal protein S4e, N-terminal, conserved site|Ribosomal protein L2, domain 2|Ribosomal protein S4, KOW domain|Ribosomal protein S4e, central region","40S ribosomal protein S4 C-terminus|RS4NT (NUC023) domain|Ribosomal protein S4e signature.|KOW_RPS4|30S ribosomal protein S4e [rps4e].|KOW motif|Ribosomal family S4e"]
["Viral mRNA Translation","N67_001121","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L36e domain superfamily|Ribosomal protein L36e","Ribosomal protein L36e|Ribosomal protein L36e signature."]
["Viral mRNA Translation","N67_001269","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L4 domain superfamily|Ribosomal protein L4/L1e|60S ribosomal protein L4, C-terminal domain","Ribosomal protein L4/L1 family|60S ribosomal protein L4 C-terminal domain"]
["Viral mRNA Translation","N67_001301","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L31e|Ribosomal protein L31e domain superfamily|Ribosomal protein L31e, conserved site","Ribosomal_L31e|Ribosomal protein L31e|Ribosomal protein L31e signature."]
["Viral mRNA Translation","N67_001338","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L37e|Ribosomal protein L37ae/L37e|Ribosomal protein L37e, conserved site","Ribosomal protein L37e|Ribosomal protein L37e signature.|50S ribosomal protein L37e [rpl37e]."]
["Viral mRNA Translation","N67_001428","structural constituent of ribosome|ribosome|translation|rRNA binding"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L6, alpha-beta domain superfamily|Ribosomal protein L6, alpha-beta domain|Ribosomal protein L6","Ribosomal protein L6"]
["Viral mRNA Translation","N67_001499","structural constituent of ribosome|ribosome|translation|large ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Mitochondrial translation initiation| Mitochondrial translation elongation| Mitochondrial translation termination| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L22/L17, conserved site|Ribosomal protein L22/L17|Ribosomal protein L22/L17 superfamily|Ribosomal protein L22, bacterial/chloroplast-type","Ribosomal protein L22 signature.|Ribosomal_L22|Ribosomal protein L22p/L17e"]
["Viral mRNA Translation","N67_001511","RNA binding|structural constituent of ribosome|translation|small ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S3, C-terminal|K homology domain-like, alpha/beta|Ribosomal protein S3, C-terminal domain superfamily|K Homology domain, type 2|Ribosomal protein S3, eukaryotic/archaeal","Ribosomal protein S3, C-terminal domain|40S_S3_KH|KH domain|uS3_euk_arch: ribosomal protein uS3|Type-2 KH domain profile."]
["Viral mRNA Translation","N67_001552","RNA binding|structural constituent of ribosome|translation|large ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L1|Ribosomal protein L1, 3-layer alpha/beta-sandwich|Ribosomal protein L1/ribosomal biogenesis protein","Ribosomal protein L1p/L10e family|Ribosomal_L1"]
["Viral mRNA Translation","N67_001628","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S13/S15, N-terminal|Ribosomal protein S15|Ribosomal protein S15P","Ribosomal S13/S15 N-terminal domain|Ribosomal_S15p_S13e|30S ribosomal protein S15 [rpsO].|Ribosomal protein S15"]
["Viral mRNA Translation","N67_001981","pseudouridine synthesis|RNA binding|RNA modification|pseudouridine synthase activity"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","RNA-binding S4 domain|Pseudouridine synthase, RsuA/RluA|Pseudouridine synthase, RsuA/RluB/E/F, catalytic domain|RNA-binding S4 domain superfamily","S4 RNA-binding domain profile.|RNA pseudouridylate synthase|S4|S4 domain"]
["Viral mRNA Translation","N67_002011","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L32e|Ribosomal protein L32e, conserved site","Ribosomal_L32_L32e|Ribosomal protein L32|Ribosomal protein L32e signature."]
["Viral mRNA Translation","N67_002095","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L44e","Ribosomal protein L44|Ribosomal protein L44e signature."]
["Viral mRNA Translation","N67_002203","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S17e, conserved site|Ribosomal protein S17e|Ribosomal protein S17e-like superfamily","Ribosomal protein S17e signature.|Ribosomal S17|30S ribosomal protein S17e [rps17e]."]
["Viral mRNA Translation","N67_002309","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L15e|Ribosomal protein L15e core domain superfamily","Ribosomal L15"]
["Viral mRNA Translation","N67_002358","structural constituent of ribosome|ribosome|translation|small ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S2|Ribosomal protein S2, eukaryotic|Ribosomal protein S2, eukaryotic/archaeal|Ribosomal protein S2, conserved site","RPS2|40S ribosomal protein SA [rps-0].|uS2_euk_arch: ribosomal protein uS2|Ribosomal protein S2|Ribosomal protein S2 signature|Ribosomal protein S2 signature 1.|Ribosomal protein S2 signature 2."]
["Viral mRNA Translation","N67_002524","structural constituent of ribosome|ribosome|translation|large ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L13|Ribosomal protein L13, eukaryotic/archaeal|Ribosomal protein L13 superfamily|Ribosomal protein L13, conserved site","Ribosomal_L13|L13_A_E: ribosomal protein uL13|50S ribosomal protein L13 [rplM].|Ribosomal protein L13|Ribosomal protein L13 signature."]
["Viral mRNA Translation","N67_002529","structural constituent of ribosome|ribosome|translation|small ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S10 domain superfamily|Ribosomal protein S10|Ribosomal protein S10, eukaryotic/archaeal|Ribosomal protein S10 domain","uS10_euk_arch: ribosomal protein uS10|Ribosomal protein S10 family signature|30S ribosomal protein S10 [rpsJ].|Ribosomal protein S10p/S20e"]
["Viral mRNA Translation","N67_002652","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L22e|Ribosomal protein L22e superfamily","Ribosomal L22e protein family"]
["Viral mRNA Translation","N67_002667","RNA binding"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","RNA-binding S4 domain","S4 RNA-binding domain profile."]
["Viral mRNA Translation","N67_002907","RNA binding"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L30e, conserved site|Ribosomal protein L30/YlxQ|50S ribosomal protein L30e-like|Ribosomal protein L7Ae/L30e/S12e/Gadd45","Ribosomal protein L30e signature 2.|Ribosomal protein L30e signature 1.|Ribosomal protein L7Ae/L30e/S12e/Gadd45 family"]
["Viral mRNA Translation","N67_002981","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S28e|Ribosomal protein S28e conserved site","30S ribosomal protein S28e [rps28e].|Ribosomal protein S28e signature.|S1_S28E|Ribosomal protein S28e"]
["Viral mRNA Translation","N67_002982","RNA binding|rRNA binding"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| rRNA modification in the nucleus and cytosol| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S4/S9|RNA-binding S4 domain|Ribosomal protein S4/S9, N-terminal|RNA-binding S4 domain superfamily","S4 domain|S4|Ribosomal protein S4/S9 N-terminal domain|S4 RNA-binding domain profile."]
["Viral mRNA Translation","N67_002984","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S10 domain superfamily|Ribosomal protein S10|Ribosomal protein S10 domain","Ribosomal protein S10p/S20e|30S ribosomal protein S10 [rpsJ]."]
["Viral mRNA Translation","N67_002986","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L27e|Eukaryotic Ribosomal Protein L27, KOW domain|Ribosomal protein L27e superfamily","KOW_RPL27|Ribosomal L27e protein family"]
["Viral mRNA Translation","N67_002990","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L29e","Ribosomal L29e protein family"]
["Viral mRNA Translation","N67_003378","RNA binding|structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L14, KOW motif|Ribosomal protein L2, domain 2|Ribosomal protein L14|Ribosomal protein L14e domain","KOW_RPL14|Ribosomal protein L14"]
["Viral mRNA Translation","N67_003427","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L21e|Ribosomal protein L21 superfamily","Ribosomal protein L21e"]
["Viral mRNA Translation","N67_003579","structural constituent of ribosome|protein binding|ribosome|translation"," Translesion synthesis by REV1| Recognition of DNA damage by PCNA-containing replication complex| Translesion Synthesis by POLH| Activation of NF-kappaB in B cells| ISG15 antiviral mechanism| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants| ER-Phagosome pathway| Downregulation of ERBB4 signaling| Spry regulation of FGF signaling| Downregulation of ERBB2:ERBB3 signaling| L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| Budding and maturation of HIV virion| NOD1/2 Signaling Pathway| TICAM1, RIP1-mediated IKK complex recruitment| DDX58/IFIH1-mediated induction of interferon-alpha/beta| APC/C:Cdc20 mediated degradation of Cyclin B| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Membrane binding and targetting of GAG proteins| Assembly Of The HIV Virion| APC-Cdc20 mediated degradation of Nek2A| SRP-dependent cotranslational protein targeting to membrane| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| EGFR downregulation| SCF(Skp2)-mediated degradation of p27/p21| Viral mRNA Translation| Degradation of beta-catenin by the destruction complex| TCF dependent signaling in response to WNT| Downstream TCR signaling| NRIF signals cell death from the nucleus| p75NTR recruits signalling complexes| NF-kB is activated and signals survival| Regulation of activated PAK-2p34 by proteasome mediated degradation| NOTCH1 Intracellular Domain Regulates Transcription| Activated NOTCH1 Transmits Signal to the Nucleus| Downregulation of TGF-beta receptor signaling| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)| Downregulation of SMAD2/3:SMAD4 transcriptional activity| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription| Selenocysteine synthesis| Separation of Sister Chromatids| Oxidative Stress Induced Senescence| Senescence-Associated Secretory Phenotype (SASP)| Oncogene Induced Senescence| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Stimuli-sensing channels| Constitutive Signaling by NOTCH1 HD Domain Mutants| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| NOTCH2 Activation and Transmission of Signal to the Nucleus| Regulation of innate immune responses to cytosolic DNA| Glycogen synthesis| Autodegradation of the E3 ubiquitin ligase COP1| Deactivation of the beta-catenin transactivating complex| Myoclonic epilepsy of Lafora| ABC-family proteins mediated transport| Circadian Clock| TAK1 activates NFkB by phosphorylation and activation of IKKs complex| activated TAK1 mediates p38 MAPK activation| JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Regulation of FZD by ubiquitination| PINK1-PRKN Mediated Mitophagy| N-glycan trimming in the ER and Calnexin/Calreticulin cycle| Regulation of TNFR1 signaling| TNFR1-induced NFkappaB signaling pathway| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Negative regulation of FGFR1 signaling| Negative regulation of FGFR2 signaling| Negative regulation of FGFR3 signaling| Negative regulation of FGFR4 signaling| Translesion synthesis by POLK| Translesion synthesis by POLI| Termination of translesion DNA synthesis| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| Negative regulation of MAPK pathway| Regulation of necroptotic cell death| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAP3K8 (TPL2)-dependent MAPK1/3 activation| HDR through Homologous Recombination (HRR)| MAPK6/MAPK4 signaling| UCH proteinases| Josephin domain DUBs| Ub-specific processing proteases| Ovarian tumor domain proteases| Metalloprotease DUBs| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks| Processing of DNA double-strand break ends| DNA Damage Recognition in GG-NER| Formation of Incision Complex in GG-NER| Gap-filling DNA repair synthesis and ligation in GG-NER| Dual Incision in GG-NER| Formation of TC-NER Pre-Incision Complex| Transcription-Coupled Nucleotide Excision Repair (TC-NER)| Dual incision in TC-NER| Gap-filling DNA repair synthesis and ligation in TC-NER| Fanconi Anemia Pathway| Major pathway of rRNA processing in the nucleolus and cytosol| Regulation of TP53 Activity through Phosphorylation| Regulation of TP53 Degradation| Regulation of TP53 Activity through Methylation| Negative regulation of MET activity| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| Cyclin D associated events in G1| G2/M Checkpoints| Stabilization of p53| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Ubiquitin-dependent degradation of Cyclin D| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Cargo recognition for clathrin-mediated endocytosis| Clathrin-mediated endocytosis| Downregulation of ERBB2 signaling| Synthesis of active ubiquitin: roles of E1 and E2 enzymes| E3 ubiquitin ligases ubiquitinate target proteins| InlB-mediated entry of Listeria monocytogenes into host cell| InlA-mediated entry of Listeria monocytogenes into host cells| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN localization| Regulation of PTEN stability and activity| Neddylation| ER Quality Control Compartment (ERQC)| Regulation of expression of SLITs and ROBOs| NOTCH3 Activation and Transmission of Signal to the Nucleus| TICAM1-dependent activation of IRF3/IRF7| TICAM1,TRAF6-dependent induction of TAK1 complex| Interleukin-1 signaling| Peroxisomal protein import| Regulation of signaling by CBL| Endosomal Sorting Complex Required For Transport (ESCRT)| Iron uptake and transport| Negative regulators of DDX58/IFIH1 signaling| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon| IRAK1 recruits IKK complex| IKK complex recruitment mediated by RIP1| IRAK2 mediated activation of TAK1 complex| TRAF6-mediated induction of TAK1 complex within TLR4 complex| Negative regulation of NOTCH4 signaling| Chaperone Mediated Autophagy| Late endosomal microautophagy| Alpha-protein kinase 1 signaling pathway| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)| Amyloid fiber formation| Antigen processing: Ubiquitination & Proteasome degradation","S27a-like superfamily|Ribosomal protein S27a|Ubiquitin-like domain","Ubl_ubiquitin_like|Ribosomal protein S27a|Ubiquitin family|Ubiquitin domain profile."]
["Viral mRNA Translation","N67_003792","RNA binding|structural constituent of ribosome|translation|small ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S7 domain|Ribosomal protein S7 domain superfamily|Ribosomal protein S5/S7, eukaryotic/archaeal|Ribosomal protein S5/S7|Ribosomal protein S7, conserved site","Ribosomal protein S7p/S5e|uS7_euk_arch: ribosomal protein uS7|Ribosomal protein S7 signature.|uS7_Eukaryote"]
["Viral mRNA Translation","N67_003811","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L5|Ribosomal protein L5, N-terminal|Ribosomal protein L5, C-terminal|Ribosomal protein L5 domain superfamily","Ribosomal protein L5|ribosomal L5P family C-terminus"]
["Viral mRNA Translation","N67_003822","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S8","Ribosomal protein S8"]
["Viral mRNA Translation","N67_003946","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S8e|Ribosomal protein S8e/ribosomal biogenesis NSA2","Ribosomal_S8e_like|eS8: ribosomal protein eS8|Ribosomal protein S8e"]
["Viral mRNA Translation","N67_004014","structural constituent of ribosome|ribosome|translation|large ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L15, conserved site|Ribosomal protein L18e/L15P|Ribosomal protein L15","Ribosomal protein L15 signature.|Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A|50S ribosomal protein L15 [rplO]."]
["Viral mRNA Translation","N67_004081","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S8","Ribosomal protein S8|Ribosomal protein S8 signature."]
["Viral mRNA Translation","N67_004120","structural constituent of ribosome|translation|large ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L2, domain 2|Ribosomal Protein L26/L24, KOW domain|KOW|Ribosomal protein L26/L24, eukaryotic/archaeal","KOW_RPL26|KOW motif|Ribosomal proteins L26 eukaryotic, L24P archaeal|rplX_A_E: ribosomal protein uL24|50S ribosomal protein L24 [rplX]."]
["Viral mRNA Translation","N67_004182","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L29/L35|Ribosomal protein L29/L35 superfamily","Ribosomal_L29_HIP|50S ribosomal protein L29 [rpmC].|Ribosomal L29 protein|L29: ribosomal protein uL29"]
["Viral mRNA Translation","N67_004194","RNA binding|structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S13|Ribosomal protein S13, conserved site|30s ribosomal protein S13, C-terminal","Ribosomal protein S13/S18|30S ribosomal protein S13 [rpsM].|Ribosomal protein S13 signature.|Ribosomal protein S13 family profile."]
["Viral mRNA Translation","N67_004236","pseudouridine synthesis|RNA binding|RNA modification|pseudouridine synthase activity"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Pseudouridine synthase, RsuA/RluA|Pseudouridine synthase, RluC/RluD, conserved site|RNA-binding S4 domain","RNA pseudouridylate synthase|Rlu family of pseudouridine synthase signature.|S4 RNA-binding domain profile."]
["Viral mRNA Translation","N67_004320","RNA binding|structural constituent of ribosome|ribosome|translation|cytosolic large ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L19/L19e|Ribosomal protein L19, eukaryotic|Ribosomal protein L19/L19e, domain 1|60S ribosomal protein L19","Ribosomal protein L19e|Ribosomal_L19e_E|50S ribosomal protein L19e [rpl19e]."]
["Viral mRNA Translation","N67_004359","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L10e|Ribosomal protein L10e/L16|Ribosomal protein L10e, conserved site|Ribosomal protein L10e/L16 superfamily","Ribosomal protein L16p/L10e|Ribosomal protein L10e signature.|Ribosomal_L16_L10e|uL16_euk_arch: ribosomal protein uL16"]
["Viral mRNA Translation","N67_004542","structural constituent of ribosome|ribosome|translational elongation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein P1/P2, N-terminal domain|Ribosomal protein L12 family","Ribosomal_P2|60s Acidic ribosomal protein|50S ribosomal protein L12 [rpl12]."]
["Viral mRNA Translation","N67_004584","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L34Ae|Ribosomal protein L34e, conserved site|Ribosomal protein L34Ae superfamily","Ribosomal protein L34 signature|50S ribosomal protein L34e [rpl34e].|Ribosomal protein L34e|Ribosomal protein L34e signature."]
["Viral mRNA Translation","N67_004628","RNA binding|structural constituent of ribosome|ribosome|translation|small ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S19, superfamily|Ribosomal protein S19/S15|Ribosomal protein S19 conserved site|Ribosomal protein S19A/S15e","Ribosomal protein S19|Ribosomal protein S19 signature.|Ribosomal protein S19 family signature|30S ribosomal protein S19 [rpsS].|uS19_arch: ribosomal protein uS19"]
["Viral mRNA Translation","N67_004647","RNA binding|structural constituent of ribosome|ribosome|translation|small ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| RMTs methylate histone arginines| rRNA modification in the nucleus and cytosol| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Protein methylation| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S5, N-terminal|Ribosomal protein S5 domain 2-type fold, subgroup|Ribosomal protein S5, eukaryotic/archaeal|Ribosomal protein S5|Ribosomal protein S5, C-terminal","Ribosomal protein S5, N-terminal domain|S5 double stranded RNA-binding domain profile.|uS5_euk_arch: ribosomal protein uS5|Ribosomal protein S5, C-terminal domain"]
["Viral mRNA Translation","N67_004672","ribosome biogenesis|ribonucleoprotein complex"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L7Ae/L8/Nhp2 family|Ribosomal protein L7A/L8|Ribosomal protein L7Ae/L30e/S12e/Gadd45|Ribosomal protein L7Ae conserved site|Ribosomal protein L7A/L8 superfamily","Ribosomal protein L7A/RS6 family signature|Ribosomal protein L7A family signature|Ribosomal protein L7Ae/L30e/S12e/Gadd45 family|Ribosomal protein L7Ae signature."]
["Viral mRNA Translation","N67_004673","structural constituent of ribosome|ribosome|translation|5S rRNA binding"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L5 eukaryotic/L18 archaeal|Ribosomal protein L5 eukaryotic/L18 archaeal, C-terminal","Ribosomal protein L5 signature|50S ribosomal protein L18 [rplR].|Ribosomal_L18_L5e|Ribosomal L18 C-terminal region|Ribosomal large subunit proteins 60S L5, and 50S L18"]
["Viral mRNA Translation","N67_004696",null," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S25","S25 ribosomal protein"]
["Viral mRNA Translation","N67_004715","pseudouridine synthesis|RNA binding|RNA modification|pseudouridine synthase activity|intramolecular transferase activity"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","RNA-binding S4 domain|Pseudouridine synthase, RsuA/RluA|Pseudouridine synthase, RsuA/RluB/E/F|Pseudouridine synthase, RsuA/RluB/E/F, conserved site|RNA-binding S4 domain superfamily|Pseudouridine synthase, RsuA/RluB/E/F, catalytic domain","S4 domain|RNA pseudouridylate synthase|S4 RNA-binding domain profile.|PseudoU_synth_RsuA_like|TIGR00093: pseudouridine synthase|S4|Rsu family of pseudouridine synthase signature."]
["Viral mRNA Translation","N67_004805","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| rRNA modification in the nucleus and cytosol| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S7e","Ribosomal protein S7e"]
["Viral mRNA Translation","N67_004932","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S24e|Ribosomal S24e conserved site","Ribosomal protein S24e|30S ribosomal protein S24e [rps24e].|Ribosomal protein S24e signature."]
["Viral mRNA Translation","N67_004959","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S17/S11|Ribosomal protein S17, conserved site|40S ribosomal protein S11, N-terminal|Ribosomal protein S17, archaeal/eukaryotic","Ribosomal protein S17|Ribosomal protein S17 signature.|Ribosomal_S17 N-terminal|Ribosomal protein S17 family signature|uS17_arch: ribosomal protein uS17"]
["Viral mRNA Translation","N67_005119","nucleotide binding|RNA binding|aminoacyl-tRNA ligase activity|tyrosine-tRNA ligase activity|ATP binding|tRNA aminoacylation for protein translation|tyrosyl-tRNA aminoacylation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Mitochondrial tRNA aminoacylation| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Tyrosine-tRNA ligase|Aminoacyl-tRNA synthetase, class Ic|Tyrosine-tRNA ligase, bacterial-type|RNA-binding S4 domain|RNA-binding S4 domain superfamily","tyrS: tyrosine--tRNA ligase|tRNA synthetases class I (W and Y)|S4 RNA-binding domain profile.|S4"]
["Viral mRNA Translation","N67_005177","structural constituent of ribosome|ribosome|translation|small ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S12/S23|Ribosomal protein S23, eukaryotic/archaeal","Ribosomal protein S12/S23|uS12_E_A: ribosomal protein uS12|Ribosomal protein S12 signature.|Ribosomal_S23"]
["Viral mRNA Translation","N67_005178","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S12e|50S ribosomal protein L30e-like|Ribosomal protein L7Ae/L30e/S12e/Gadd45","Ribosomal protein S12e signature.|Ribosomal protein S12E family signature|Ribosomal protein L7Ae/L30e/S12e/Gadd45 family"]
["Viral mRNA Translation","N67_005206","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L2|Ribosomal protein L2, domain 2|Ribosomal protein L2, C-terminal|Ribosomal protein L2, conserved site|Ribosomal Proteins L2, RNA binding domain|Ribosomal protein L2, domain 3","Ribosomal protein L2 signature.|Ribosomal Proteins L2, C-terminal domain|Ribosomal Proteins L2, RNA binding domain"]
["Viral mRNA Translation","N67_005207","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L11, C-terminal domain superfamily|Ribosomal protein L11/L12|Ribosomal protein L11, N-terminal|Ribosomal protein L11/L12, N-terminal domain superfamily|Ribosomal protein L11, C-terminal|Ribosomal protein L11, conserved site","Ribosomal_L11|50S ribosomal protein L11 [rplK].|Ribosomal protein L11, N-terminal domain|Ribosomal protein L11, RNA binding domain|Ribosomal protein L11 signature."]
["Viral mRNA Translation","N67_005241","RNA binding|structural constituent of ribosome|translation|small ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| rRNA modification in the nucleus and cytosol| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","RNA-binding S4 domain|Ribosomal protein S4/S9|RNA-binding S4 domain superfamily|Ribosomal protein S4, bacterial-type","S4 domain|S4 RNA-binding domain profile."]
["Viral mRNA Translation","N67_005243","structural constituent of ribosome|ribosome|translation"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Major pathway of rRNA processing in the nucleolus and cytosol| Formation of a pool of free 40S subunits| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L2, domain 2|Ribosomal protein L2|Ribosomal protein L2, domain 3|Ribosomal protein L2, C-terminal|Ribosomal Proteins L2, RNA binding domain","Ribosomal Proteins L2, C-terminal domain|Ribosomal Proteins L2, RNA binding domain"]
["Viral mRNA Translation","N67_005244","structural constituent of ribosome|ribosome|translation|rRNA binding"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| Mitochondrial translation initiation| Mitochondrial translation elongation| Mitochondrial translation termination| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein L14 superfamily|Ribosomal protein L14P|Ribosomal protein L10e/L16|Ribosomal protein L16|Ribosomal protein L10e/L16 superfamily|Ribosomal protein S3, C-terminal|Ribosomal protein S3, C-terminal domain superfamily","50S ribosomal protein L14 [rplN].|Ribosomal_L16_L10e|Ribosomal protein L16p/L10e|Ribosomal protein L16 signature|Ribosomal protein L14p/L23e|Ribosomal protein S3, C-terminal domain"]
["Viral mRNA Translation","N67_005245","RNA binding|structural constituent of ribosome|ribosome|translation",null,"Ribosomal protein S5, N-terminal","S5 double stranded RNA-binding domain profile.|Ribosomal protein S5, N-terminal domain"]
["Viral mRNA Translation","N67_005266","RNA binding|structural constituent of ribosome|translation|small ribosomal subunit|rRNA binding"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| rRNA modification in the nucleus and cytosol| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","Ribosomal protein S4/S9, N-terminal|Ribosomal protein S4/S9|RNA-binding S4 domain superfamily|RNA-binding S4 domain|Ribosomal protein S4, conserved site|Ribosomal protein S4/S9, eukaryotic/archaeal","S4|Ribosomal protein S4/S9 N-terminal domain|S4 RNA-binding domain profile.|S4 domain|Ribosomal protein S4 signature.|uS4_arch: ribosomal protein uS4"]
["Viral mRNA Translation","N67_005346","RNA binding|structural constituent of ribosome|translation|small ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| rRNA modification in the nucleus and cytosol| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","RNA-binding S4 domain|Ribosomal protein S4/S9|Ribosomal protein S4, bacterial-type|RNA-binding S4 domain superfamily","S4 domain|S4 RNA-binding domain profile."]
["Viral mRNA Translation","N67_005347","RNA binding|structural constituent of ribosome|translation|small ribosomal subunit"," L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| SRP-dependent cotranslational protein targeting to membrane| Viral mRNA Translation| Selenocysteine synthesis| rRNA modification in the nucleus and cytosol| Major pathway of rRNA processing in the nucleolus and cytosol| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Regulation of expression of SLITs and ROBOs| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)","RNA-binding S4 domain|Ribosomal protein S4/S9|Ribosomal protein S4, bacterial-type|RNA-binding S4 domain superfamily","S4 domain|S4 RNA-binding domain profile."]
["Downstream TCR signaling","N67_000073","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit 3|26S proteasome regulatory subunit, C-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|Proteasome regulatory subunit C-terminal|PCI domain profile."]
["Downstream TCR signaling","N67_000266","enzyme regulator activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 6|26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1","PCI domain|PCI domain profile.|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|26S proteasome subunit RPN7"]
["Downstream TCR signaling","N67_000276","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA+ ATPase domain|ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|ATPase, AAA-type, conserved site|AAA ATPase, AAA+ lid domain|26S proteasome regulatory subunit P45-like","ATPase family associated with various cellular activities (AAA)|AAA|Proteasomal ATPase OB C-terminal domain|AAA-protein family signature.|AAA+ lid domain|26Sp45: 26S proteasome subunit P45 family"]
["Downstream TCR signaling","N67_000509","peptidase activator activity|lysine-acetylated histone binding|proteasome binding"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator complex subunit 4 C-terminal domain|Proteasome activator complex subunit 4","Domain of unknown function (DUF3437)"]
["Downstream TCR signaling","N67_000697","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome B-type subunit|Proteasome beta-type subunit, conserved site|Peptidase T1A, proteasome beta-subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|proteasome_beta_type_5|Proteasome beta-type subunit profile.|Proteasome beta-type subunits signature.|Proteasome component signature"]
["Downstream TCR signaling","N67_000728","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA ATPase, AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA+ ATPase domain|ATPase, AAA-type, conserved site|ATPase, AAA-type, core|26S proteasome regulatory subunit P45-like","AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA|AAA-protein family signature.|ATPase family associated with various cellular activities (AAA)|26Sp45: 26S proteasome subunit P45 family"]
["Downstream TCR signaling","N67_000908",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 13","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain"]
["Downstream TCR signaling","N67_001466","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit beta 2|Proteasome beta-type subunit, conserved site|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome beta-type subunits signature.|proteasome_beta_type_2|Proteasome subunit"]
["Downstream TCR signaling","N67_001507","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Hypusine synthesis from eIF5A-lysine| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S Proteasome non-ATPase regulatory subunit 1|26S proteasome regulatory subunit RPN2, C-terminal|Proteasome/cyclosome repeat|PBS lyase HEAT-like repeat|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit","26S proteasome regulatory subunit RPN2 C-terminal domain|Proteasome/cyclosome repeat|E-Z type HEAT repeats|HEAT repeats"]
["Downstream TCR signaling","N67_001583","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha 1|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|proteasome_alpha_type_1"]
["Downstream TCR signaling","N67_001700","ubiquitin-dependent protein catabolic process"," Activation of NF-kappaB in B cells| Prolactin receptor signaling| SCF-beta-TrCP mediated degradation of Emi1| Vpu mediated degradation of CD4| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| NOTCH1 Intracellular Domain Regulates Transcription| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| Circadian Clock| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| NIK-->noncanonical NF-kB signaling| MAP3K8 (TPL2)-dependent MAPK1/3 activation| Orc1 removal from chromatin| Cyclin D associated events in G1| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Regulation of RUNX2 expression and activity| Neddylation| Interleukin-1 signaling| Iron uptake and transport| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","SKP1 component, POZ domain|S-phase kinase-associated protein 1-like|S-phase kinase-associated protein 1|SKP1 component, dimerisation","Skp1 family, tetramerisation domain|BTB_POZ_SKP1|Skp1 family, dimerisation domain"]
["Downstream TCR signaling","N67_001710","protein binding|metallopeptidase activity|Lys63-specific deubiquitinase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Metalloprotease DUBs| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","MPN domain|26S Proteasome non-ATPase regulatory subunit 14|JAB1/MPN/MOV34 metalloenzyme domain|Rpn11/EIF3F, C-terminal","MPN domain profile.|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN_RPN11_CSN5|Maintenance of mitochondrial structure and function"]
["Downstream TCR signaling","N67_001726","threonine-type endopeptidase activity|proteasome core complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome subunit beta Pre3|Nucleophile aminohydrolases, N-terminal","Proteasome subunit"]
["Downstream TCR signaling","N67_001963","threonine-type endopeptidase activity|proteasome core complex|proteolysis|HslUV protease complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATP-dependent protease, HslV subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome B-type subunit","ATP_dep_HslV: ATP-dependent protease HslVU, peptidase subunit|Proteasome subunit|Proteasome beta-type subunit profile.|protease_HslV"]
["Downstream TCR signaling","N67_002329","ATP binding|cytoplasm|hydrolase activity|protein catabolic process|proteasome-activating ATPase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|26S proteasome regulatory subunit P45-like|ATPase, AAA-type, conserved site|AAA+ ATPase domain|AAA ATPase, AAA+ lid domain|26S Proteasome regulatory subunit 6B","ATPase family associated with various cellular activities (AAA)|Proteasomal ATPase OB C-terminal domain|26Sp45: 26S proteasome subunit P45 family|AAA|AAA-protein family signature.|AAA+ lid domain"]
["Downstream TCR signaling","N67_002487","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteasome core complex, beta-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta 3 subunit|Proteasome beta-type subunit, conserved site","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_3|Proteasome beta-type subunits signature."]
["Downstream TCR signaling","N67_002738","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha5|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit A N-terminal signature|Proteasome alpha-type subunits signature.|proteasome_alpha_type_5|Proteasome subunit|Proteasome alpha-type subunit profile."]
["Downstream TCR signaling","N67_002863","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Proteasome subunit alpha2","proteasome_alpha_type_2|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|Proteasome subunit"]
["Downstream TCR signaling","N67_002919",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit RPN5, C-terminal domain|26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4|Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 12|Winged helix-like DNA-binding domain superfamily","26S proteasome regulatory subunit RPN5 C-terminal domain|PCI domain profile.|PCI domain|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15"]
["Downstream TCR signaling","N67_003190","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 7|Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Peptidase T1A, proteasome beta-subunit","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_7|Proteasome beta-type subunit profile.|Proteasome component signature"]
["Downstream TCR signaling","N67_003578",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome regulatory subunit Rpn6, N-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|PCI domain profile.|26S proteasome regulatory subunit RPN6 N-terminal domain"]
["Downstream TCR signaling","N67_003579","structural constituent of ribosome|protein binding|ribosome|translation"," Translesion synthesis by REV1| Recognition of DNA damage by PCNA-containing replication complex| Translesion Synthesis by POLH| Activation of NF-kappaB in B cells| ISG15 antiviral mechanism| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants| ER-Phagosome pathway| Downregulation of ERBB4 signaling| Spry regulation of FGF signaling| Downregulation of ERBB2:ERBB3 signaling| L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| Budding and maturation of HIV virion| NOD1/2 Signaling Pathway| TICAM1, RIP1-mediated IKK complex recruitment| DDX58/IFIH1-mediated induction of interferon-alpha/beta| APC/C:Cdc20 mediated degradation of Cyclin B| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Membrane binding and targetting of GAG proteins| Assembly Of The HIV Virion| APC-Cdc20 mediated degradation of Nek2A| SRP-dependent cotranslational protein targeting to membrane| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| EGFR downregulation| SCF(Skp2)-mediated degradation of p27/p21| Viral mRNA Translation| Degradation of beta-catenin by the destruction complex| TCF dependent signaling in response to WNT| Downstream TCR signaling| NRIF signals cell death from the nucleus| p75NTR recruits signalling complexes| NF-kB is activated and signals survival| Regulation of activated PAK-2p34 by proteasome mediated degradation| NOTCH1 Intracellular Domain Regulates Transcription| Activated NOTCH1 Transmits Signal to the Nucleus| Downregulation of TGF-beta receptor signaling| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)| Downregulation of SMAD2/3:SMAD4 transcriptional activity| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription| Selenocysteine synthesis| Separation of Sister Chromatids| Oxidative Stress Induced Senescence| Senescence-Associated Secretory Phenotype (SASP)| Oncogene Induced Senescence| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Stimuli-sensing channels| Constitutive Signaling by NOTCH1 HD Domain Mutants| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| NOTCH2 Activation and Transmission of Signal to the Nucleus| Regulation of innate immune responses to cytosolic DNA| Glycogen synthesis| Autodegradation of the E3 ubiquitin ligase COP1| Deactivation of the beta-catenin transactivating complex| Myoclonic epilepsy of Lafora| ABC-family proteins mediated transport| Circadian Clock| TAK1 activates NFkB by phosphorylation and activation of IKKs complex| activated TAK1 mediates p38 MAPK activation| JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Regulation of FZD by ubiquitination| PINK1-PRKN Mediated Mitophagy| N-glycan trimming in the ER and Calnexin/Calreticulin cycle| Regulation of TNFR1 signaling| TNFR1-induced NFkappaB signaling pathway| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Negative regulation of FGFR1 signaling| Negative regulation of FGFR2 signaling| Negative regulation of FGFR3 signaling| Negative regulation of FGFR4 signaling| Translesion synthesis by POLK| Translesion synthesis by POLI| Termination of translesion DNA synthesis| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| Negative regulation of MAPK pathway| Regulation of necroptotic cell death| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAP3K8 (TPL2)-dependent MAPK1/3 activation| HDR through Homologous Recombination (HRR)| MAPK6/MAPK4 signaling| UCH proteinases| Josephin domain DUBs| Ub-specific processing proteases| Ovarian tumor domain proteases| Metalloprotease DUBs| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks| Processing of DNA double-strand break ends| DNA Damage Recognition in GG-NER| Formation of Incision Complex in GG-NER| Gap-filling DNA repair synthesis and ligation in GG-NER| Dual Incision in GG-NER| Formation of TC-NER Pre-Incision Complex| Transcription-Coupled Nucleotide Excision Repair (TC-NER)| Dual incision in TC-NER| Gap-filling DNA repair synthesis and ligation in TC-NER| Fanconi Anemia Pathway| Major pathway of rRNA processing in the nucleolus and cytosol| Regulation of TP53 Activity through Phosphorylation| Regulation of TP53 Degradation| Regulation of TP53 Activity through Methylation| Negative regulation of MET activity| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| Cyclin D associated events in G1| G2/M Checkpoints| Stabilization of p53| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Ubiquitin-dependent degradation of Cyclin D| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Cargo recognition for clathrin-mediated endocytosis| Clathrin-mediated endocytosis| Downregulation of ERBB2 signaling| Synthesis of active ubiquitin: roles of E1 and E2 enzymes| E3 ubiquitin ligases ubiquitinate target proteins| InlB-mediated entry of Listeria monocytogenes into host cell| InlA-mediated entry of Listeria monocytogenes into host cells| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN localization| Regulation of PTEN stability and activity| Neddylation| ER Quality Control Compartment (ERQC)| Regulation of expression of SLITs and ROBOs| NOTCH3 Activation and Transmission of Signal to the Nucleus| TICAM1-dependent activation of IRF3/IRF7| TICAM1,TRAF6-dependent induction of TAK1 complex| Interleukin-1 signaling| Peroxisomal protein import| Regulation of signaling by CBL| Endosomal Sorting Complex Required For Transport (ESCRT)| Iron uptake and transport| Negative regulators of DDX58/IFIH1 signaling| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon| IRAK1 recruits IKK complex| IKK complex recruitment mediated by RIP1| IRAK2 mediated activation of TAK1 complex| TRAF6-mediated induction of TAK1 complex within TLR4 complex| Negative regulation of NOTCH4 signaling| Chaperone Mediated Autophagy| Late endosomal microautophagy| Alpha-protein kinase 1 signaling pathway| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)| Amyloid fiber formation| Antigen processing: Ubiquitination & Proteasome degradation","S27a-like superfamily|Ribosomal protein S27a|Ubiquitin-like domain","Ubl_ubiquitin_like|Ribosomal protein S27a|Ubiquitin family|Ubiquitin domain profile."]
["Downstream TCR signaling","N67_003696","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core|AAA+ ATPase domain|ATPase, AAA-type, conserved site","26Sp45: 26S proteasome subunit P45 family|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA|AAA-protein family signature."]
["Downstream TCR signaling","N67_004122","proteasome regulatory particle|proteolysis"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","CSN8/PSMD8/EIF3K|Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit Rpn12","CSN8/PSMD8/EIF3K family|PCI domain profile."]
["Downstream TCR signaling","N67_004247","protein binding|proteasome regulatory particle"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S Proteasome non-ATPase regulatory subunit 7/8|JAB1/MPN/MOV34 metalloenzyme domain|MPN domain|Rpn11/EIF3F, C-terminal","MPN_RPN7_8|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN domain profile.|Maintenance of mitochondrial structure and function"]
["Downstream TCR signaling","N67_004346","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 4","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_4"]
["Downstream TCR signaling","N67_004467","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal","Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|Proteasome subunit|Proteasome subunit A N-terminal signature|proteasome_alpha_type_7"]
["Downstream TCR signaling","N67_004468","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit|Proteasome subunit A N-terminal signature|Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|proteasome_alpha_type_4"]
["Downstream TCR signaling","N67_004565","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha6|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit","proteasome_alpha_type_6|Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature"]
["Downstream TCR signaling","N67_004752","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA+ ATPase domain|ATPase, AAA-type, conserved site|Proteasomal ATPase OB C-terminal domain|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core","26Sp45: 26S proteasome subunit P45 family|AAA-protein family signature.|Proteasomal ATPase OB C-terminal domain|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA"]
["Downstream TCR signaling","N67_004822","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit|RPN1/RPN2, N-terminal|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1, C-terminal","RPN1/RPN2 N-terminal domain|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1 C-terminal"]
["Downstream TCR signaling","N67_004943","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 1|Nucleophile aminohydrolases, N-terminal","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_1|Proteasome beta-type subunits signature."]
["Downstream TCR signaling","N67_004957","protein binding|proteasome regulatory particle assembly"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","PDZ superfamily|Nas2, N-terminal|26S Proteasome non-ATPase regulatory subunit 9","Nas2 N_terminal domain"]
["Downstream TCR signaling","N67_004966","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit alpha 3|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome subunit A N-terminal signature|Proteasome subunit"]
["Downstream TCR signaling","N67_005012","proteasome activator complex"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator PA28|Proteasome activator PA28, C-terminal domain superfamily|Proteasome activator PA28, C-terminal domain","Proteasome activator pa28 beta subunit"]
["MHC class II antigen presentation","N67_000138","dynactin complex|microtubule-based process"," MHC class II antigen presentation| Regulation of PLK1 Activity at G2/M Transition| HSP90 chaperone cycle for steroid hormone receptors (SHR)| Loss of Nlp from mitotic centrosomes| Recruitment of mitotic centrosome proteins and complexes| Loss of proteins required for interphase microtubule organization from the centrosome| Recruitment of NuMA to mitotic centrosomes| Anchoring of the basal body to the plasma membrane| COPI-mediated anterograde transport| COPI-independent Golgi-to-ER retrograde traffic| AURKA Activation by TPX2","Dynamitin","Dynamitin"]
["MHC class II antigen presentation","N67_000725","GTPase activity|structural constituent of cytoskeleton|GTP binding|microtubule|microtubule-based process"," Translocation of SLC2A4 (GLUT4) to the plasma membrane| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane| Gap junction assembly| MHC class II antigen presentation| Separation of Sister Chromatids| Resolution of Sister Chromatid Cohesion| HSP90 chaperone cycle for steroid hormone receptors (SHR)| Recruitment of NuMA to mitotic centrosomes| Recycling pathway of L1| Cilium Assembly| RHO GTPases activate IQGAPs| RHO GTPases Activate Formins| COPI-mediated anterograde transport| COPI-dependent Golgi-to-ER retrograde traffic| COPI-independent Golgi-to-ER retrograde traffic| Mitotic Prometaphase| The role of GTSE1 in G2/M progression after G2 checkpoint| Carboxyterminal post-translational modifications of tubulin| Assembly and cell surface presentation of NMDA receptors| Activation of AMPK downstream of NMDARs| Kinesins","Tubulin/FtsZ, GTPase domain|Tubulin/FtsZ, 2-layer sandwich domain|Tubulin/FtsZ, C-terminal domain superfamily|Tubulin|Tubulin, C-terminal|Beta tubulin|Beta tubulin, autoregulation binding site|Tubulin/FtsZ, GTPase domain superfamily|Tubulin, conserved site","Tubulin/FtsZ family, GTPase domain|Tubulin C-terminal domain|Tubulin signature|Beta-tubulin signature|beta_tubulin|Tubulin-beta mRNA autoregulation signal.|Tubulin subunits alpha, beta, and gamma signature."]
["MHC class II antigen presentation","N67_000839","intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|COPII vesicle coat"," Regulation of cholesterol biosynthesis by SREBP (SREBF)| COPII-mediated vesicle transport| MHC class II antigen presentation| Cargo concentration in the ER| Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sec23/Sec24 beta-sandwich|Sec23/Sec24, helical domain|Sec23/Sec24, trunk domain","Sec23/Sec24 beta-sandwich domain|Sec23/Sec24 helical domain|Sec23/Sec24 trunk domain"]
["MHC class II antigen presentation","N67_000842","proteolysis|cysteine-type peptidase activity"," COPII-mediated vesicle transport| MHC class II antigen presentation| Cargo concentration in the ER| Neutrophil degranulation","Peptidase C1A, papain C-terminal|Cysteine peptidase, histidine active site|Cathepsin C, exclusion domain superfamily|Cathepsin C exclusion|Cysteine peptidase, cysteine active site","Papain family cysteine protease|Eukaryotic thiol (cysteine) proteases histidine active site.|Cathepsin C exclusion domain|Eukaryotic thiol (cysteine) proteases cysteine active site."]
["MHC class II antigen presentation","N67_000987","GTPase activity|structural constituent of cytoskeleton|GTP binding|microtubule|microtubule-based process"," Translocation of SLC2A4 (GLUT4) to the plasma membrane| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane| Gap junction assembly| MHC class II antigen presentation| Separation of Sister Chromatids| Resolution of Sister Chromatid Cohesion| HSP90 chaperone cycle for steroid hormone receptors (SHR)| Recruitment of NuMA to mitotic centrosomes| Formation of tubulin folding intermediates by CCT/TriC| Post-chaperonin tubulin folding pathway| Recycling pathway of L1| Cilium Assembly| RHO GTPases activate IQGAPs| RHO GTPases Activate Formins| COPI-mediated anterograde transport| COPI-dependent Golgi-to-ER retrograde traffic| COPI-independent Golgi-to-ER retrograde traffic| Mitotic Prometaphase| The role of GTSE1 in G2/M progression after G2 checkpoint| Carboxyterminal post-translational modifications of tubulin| Assembly and cell surface presentation of NMDA receptors| Activation of AMPK downstream of NMDARs| Kinesins","Tubulin, conserved site|Tubulin|Tubulin/FtsZ, GTPase domain|Tubulin/FtsZ, C-terminal domain superfamily|Tubulin/FtsZ, 2-layer sandwich domain|Tubulin/FtsZ, GTPase domain superfamily|Alpha tubulin|Tubulin, C-terminal","Tubulin subunits alpha, beta, and gamma signature.|Tubulin/FtsZ family, GTPase domain|Tubulin C-terminal domain|alpha_tubulin|Alpha-tubulin signature|Tubulin signature"]
["MHC class II antigen presentation","N67_001173","proteolysis|cysteine-type peptidase activity"," MHC class II antigen presentation","Papain-like cysteine endopeptidase|Cathepsin propeptide inhibitor domain (I29)|Peptidase C1A, papain C-terminal","Peptidase_C1A|Cathepsin propeptide inhibitor domain (I29)|Papain cysteine protease (C1) family signature|Papain family cysteine protease"]
["MHC class II antigen presentation","N67_001592","GTPase activity|GTP binding|microtubule|microtubule-based process"," Translocation of SLC2A4 (GLUT4) to the plasma membrane| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane| Gap junction assembly| MHC class II antigen presentation| Separation of Sister Chromatids| Resolution of Sister Chromatid Cohesion| HSP90 chaperone cycle for steroid hormone receptors (SHR)| Recruitment of NuMA to mitotic centrosomes| Recycling pathway of L1| Cilium Assembly| RHO GTPases activate IQGAPs| RHO GTPases Activate Formins| COPI-mediated anterograde transport| COPI-dependent Golgi-to-ER retrograde traffic| COPI-independent Golgi-to-ER retrograde traffic| Mitotic Prometaphase| The role of GTSE1 in G2/M progression after G2 checkpoint| Carboxyterminal post-translational modifications of tubulin| Assembly and cell surface presentation of NMDA receptors| Activation of AMPK downstream of NMDARs| Kinesins","Tubulin/FtsZ, 2-layer sandwich domain|Tubulin, C-terminal|Epsilon tubulin|Tubulin, conserved site|Tubulin|Tubulin/FtsZ, GTPase domain|Tubulin/FtsZ, GTPase domain superfamily","Tubulin C-terminal domain|Epsilon-tubulin signature|epsilon_tubulin|Tubulin subunits alpha, beta, and gamma signature.|Tubulin signature|Tubulin/FtsZ family, GTPase domain"]
["MHC class II antigen presentation","N67_001646","intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|COPII vesicle coat"," Regulation of cholesterol biosynthesis by SREBP (SREBF)| COPII-mediated vesicle transport| MHC class II antigen presentation| Cargo concentration in the ER| Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Sec23/Sec24, trunk domain|Sec23/Sec24, helical domain|Zinc finger, Sec23/Sec24-type|Gelsolin-like domain|ADF-H/Gelsolin-like domain superfamily|von Willebrand factor A-like domain superfamily|Sec23/Sec24 beta-sandwich","Sec23/Sec24 trunk domain|Sec23/Sec24 helical domain|Sec23/Sec24 zinc finger|Gelsolin repeat|Sec23/Sec24 beta-sandwich domain"]
["MHC class II antigen presentation","N67_001960","structural molecule activity|protein binding|vesicle-mediated transport|COPII vesicle coat|COPII-coated vesicle budding|positive regulation of TORC1 signaling"," ISG15 antiviral mechanism| Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal| Transport of the SLBP independent Mature mRNA| Transport of the SLBP Dependant Mature mRNA| Transport of Mature mRNA Derived from an Intronless Transcript| Transport of Mature mRNA derived from an Intron-Containing Transcript| Rev-mediated nuclear export of HIV RNA| Transport of Ribonucleoproteins into the Host Nucleus| NS1 Mediated Effects on Host Pathways| Viral Messenger RNA Synthesis| NEP/NS2 Interacts with the Cellular Export Machinery| Regulation of Glucokinase by Glucokinase Regulatory Protein| Nuclear import of Rev protein| Vpr-mediated nuclear import of PICs| snRNP Assembly| COPII-mediated vesicle transport| MHC class II antigen presentation| Separation of Sister Chromatids| Resolution of Sister Chromatid Cohesion| SUMOylation of DNA damage response and repair proteins| SUMOylation of ubiquitinylation proteins| Nuclear Pore Complex (NPC) Disassembly| Regulation of HSF1-mediated heat shock response| SUMOylation of SUMOylation proteins| SUMOylation of chromatin organization proteins| SUMOylation of RNA binding proteins| SUMOylation of DNA replication proteins| Transcriptional regulation by small RNAs| Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)| RHO GTPases Activate Formins| tRNA processing in the nucleus| Mitotic Prometaphase| Amino acids regulate mTORC1| Antigen Presentation: Folding, assembly and peptide loading of class I MHC","WD40-repeat-containing domain|Sec13/Seh1 family|WD40 repeat|Protein Sec13|WD40/YVTN repeat-like-containing domain superfamily","Trp-Asp (WD) repeats circular profile.|WD domain, G-beta repeat"]
["MHC class II antigen presentation","N67_002013","GTPase activity|structural constituent of cytoskeleton|GTP binding|microtubule|microtubule-based process"," Translocation of SLC2A4 (GLUT4) to the plasma membrane| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane| Gap junction assembly| MHC class II antigen presentation| Separation of Sister Chromatids| Resolution of Sister Chromatid Cohesion| HSP90 chaperone cycle for steroid hormone receptors (SHR)| Recruitment of NuMA to mitotic centrosomes| Formation of tubulin folding intermediates by CCT/TriC| Post-chaperonin tubulin folding pathway| Recycling pathway of L1| Cilium Assembly| RHO GTPases activate IQGAPs| RHO GTPases Activate Formins| COPI-mediated anterograde transport| COPI-dependent Golgi-to-ER retrograde traffic| COPI-independent Golgi-to-ER retrograde traffic| Mitotic Prometaphase| The role of GTSE1 in G2/M progression after G2 checkpoint| Carboxyterminal post-translational modifications of tubulin| Assembly and cell surface presentation of NMDA receptors| Activation of AMPK downstream of NMDARs| Kinesins","Tubulin/FtsZ, GTPase domain|Alpha tubulin|Tubulin, C-terminal|Tubulin/FtsZ, C-terminal domain superfamily|Tubulin/FtsZ, GTPase domain superfamily|Tubulin|Tubulin, conserved site|Tubulin/FtsZ, 2-layer sandwich domain","Alpha-tubulin signature|Tubulin/FtsZ family, GTPase domain|Tubulin signature|Tubulin subunits alpha, beta, and gamma signature.|alpha_tubulin|Tubulin C-terminal domain"]
["MHC class II antigen presentation","N67_002234","dynactin complex|cytoskeleton-dependent cytokinesis"," MHC class II antigen presentation| Regulation of PLK1 Activity at G2/M Transition| HSP90 chaperone cycle for steroid hormone receptors (SHR)| Loss of Nlp from mitotic centrosomes| Recruitment of mitotic centrosome proteins and complexes| Loss of proteins required for interphase microtubule organization from the centrosome| Recruitment of NuMA to mitotic centrosomes| Anchoring of the basal body to the plasma membrane| COPI-mediated anterograde transport| COPI-independent Golgi-to-ER retrograde traffic| AURKA Activation by TPX2","Dynactin subunit 3","Dynactin subunit p22"]
["MHC class II antigen presentation","N67_002642","intracellular protein transport|endoplasmic reticulum to Golgi vesicle-mediated transport|zinc ion binding|COPII vesicle coat"," Regulation of cholesterol biosynthesis by SREBP (SREBF)| COPII-mediated vesicle transport| MHC class II antigen presentation| Cargo concentration in the ER| Antigen Presentation: Folding, assembly and peptide loading of class I MHC","Zinc finger, Sec23/Sec24-type|Sec23/Sec24, trunk domain|Sec23/Sec24 beta-sandwich|ADF-H/Gelsolin-like domain superfamily|Protein transport protein Sec23|von Willebrand factor A-like domain superfamily|Gelsolin-like domain|Sec23/Sec24, helical domain","Sec23/Sec24 zinc finger|Sec23/Sec24 trunk domain|Sec23/Sec24 beta-sandwich domain|Gelsolin repeat|Sec23/Sec24 helical domain"]
["MHC class II antigen presentation","N67_002730",null," MHC class II antigen presentation| HSP90 chaperone cycle for steroid hormone receptors (SHR)| Neutrophil degranulation| COPI-mediated anterograde transport| COPI-independent Golgi-to-ER retrograde traffic","Actin family|Actin-related protein 10","Actin"]
["MHC class II antigen presentation","N67_003011","proteolysis|cysteine-type peptidase activity"," MHC class II antigen presentation","Papain-like cysteine endopeptidase|Cathepsin propeptide inhibitor domain (I29)|Peptidase C1A, papain C-terminal|Cysteine peptidase, asparagine active site|Cysteine peptidase, cysteine active site|Cysteine peptidase, histidine active site","Peptidase_C1A|Cathepsin propeptide inhibitor domain (I29)|Papain family cysteine protease|Eukaryotic thiol (cysteine) proteases asparagine active site.|Eukaryotic thiol (cysteine) proteases cysteine active site.|Eukaryotic thiol (cysteine) proteases histidine active site.|Papain cysteine protease (C1) family signature"]
["MHC class II antigen presentation","N67_003107","intracellular protein transport|protein transport|vesicle-mediated transport|membrane coat|clathrin adaptor complex|clathrin binding"," MHC class II antigen presentation","TBP domain superfamily|Beta-adaptin appendage, C-terminal subdomain|Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain|Clathrin/coatomer adaptor, adaptin-like, N-terminal|AP-1/2/4 complex subunit beta|Armadillo-like helical|AP complex subunit beta","Beta2-adaptin appendage, C-terminal sub-domain|Adaptin N terminal region"]
["MHC class II antigen presentation","N67_004078","microtubule motor activity|cytoplasmic dynein complex|microtubule-based movement"," Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal| MHC class II antigen presentation| Separation of Sister Chromatids| Resolution of Sister Chromatid Cohesion| HSP90 chaperone cycle for steroid hormone receptors (SHR)| RHO GTPases Activate Formins| COPI-mediated anterograde transport| COPI-independent Golgi-to-ER retrograde traffic| Mitotic Prometaphase","Dynein family light intermediate chain|Dynein 1 light intermediate chain","Dynein light intermediate chain (DLIC)"]
["MHC class II antigen presentation","N67_004345","gamma-tubulin complex|GTPase activity|GTP binding|microtubule|microtubule-based process|microtubule nucleation|cytoplasmic microtubule organization"," Translocation of SLC2A4 (GLUT4) to the plasma membrane| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane| Gap junction assembly| MHC class II antigen presentation| Separation of Sister Chromatids| Resolution of Sister Chromatid Cohesion| HSP90 chaperone cycle for steroid hormone receptors (SHR)| Recruitment of mitotic centrosome proteins and complexes| Recruitment of NuMA to mitotic centrosomes| Recycling pathway of L1| Cilium Assembly| RHO GTPases activate IQGAPs| RHO GTPases Activate Formins| COPI-mediated anterograde transport| COPI-dependent Golgi-to-ER retrograde traffic| COPI-independent Golgi-to-ER retrograde traffic| Mitotic Prometaphase| The role of GTSE1 in G2/M progression after G2 checkpoint| Carboxyterminal post-translational modifications of tubulin| Assembly and cell surface presentation of NMDA receptors| Activation of AMPK downstream of NMDARs| Kinesins","Tubulin/FtsZ, 2-layer sandwich domain|Tubulin/FtsZ, GTPase domain|Tubulin, conserved site|Tubulin/FtsZ, C-terminal domain superfamily|Tubulin, C-terminal|Tubulin|Tubulin/FtsZ, GTPase domain superfamily|Gamma tubulin","Tubulin C-terminal domain|Tubulin subunits alpha, beta, and gamma signature.|Tubulin signature|Gamma-tubulin signature|gamma_tubulin|Tubulin/FtsZ family, GTPase domain"]
["MHC class II antigen presentation","N67_004462","dynactin complex"," MHC class II antigen presentation| HSP90 chaperone cycle for steroid hormone receptors (SHR)| COPI-mediated anterograde transport| COPI-independent Golgi-to-ER retrograde traffic","Dynactin subunit 4"]
["MHC class II antigen presentation","N67_004733","intracellular protein transport|protein transport|vesicle-mediated transport|membrane coat|AP-2 adaptor complex|clathrin adaptor activity|clathrin-dependent endocytosis"," Nef Mediated CD4 Down-regulation| Retrograde neurotrophin signalling| Nef Mediated CD8 Down-regulation| MHC class II antigen presentation| EPH-ephrin mediated repulsion of cells| Trafficking of GluR2-containing AMPA receptors| Recycling pathway of L1| WNT5A-dependent internalization of FZD4| WNT5A-dependent internalization of FZD2, FZD5 and ROR2| Cargo recognition for clathrin-mediated endocytosis| Clathrin-mediated endocytosis| VLDLR internalisation and degradation| LDL clearance","Adaptor protein complex, sigma subunit|Clathrin adaptor complex, small chain|AP complex, mu/sigma subunit|AP-2 complex subunit sigma","Clathrin adaptor complexes small chain signature.|AP2_sigma|Clathrin adaptor complex small chain"]
["MHC class II antigen presentation","N67_004949","F-actin capping protein complex|barbed-end actin filament capping"," MHC class II antigen presentation| HSP90 chaperone cycle for steroid hormone receptors (SHR)| COPI-mediated anterograde transport| COPI-independent Golgi-to-ER retrograde traffic| Factors involved in megakaryocyte development and platelet production","F-actin-capping protein subunit alpha/beta, domain 2|F-actin-capping protein subunit beta|F-actin-capping protein subunit beta, N-terminal domain","F-actin capping protein, beta subunit|F-actin capping protein beta subunit signature"]
["MHC class II antigen presentation","N67_005061","dynactin complex"," MHC class II antigen presentation| HSP90 chaperone cycle for steroid hormone receptors (SHR)| COPI-mediated anterograde transport| COPI-independent Golgi-to-ER retrograde traffic","Dynactin subunit 6"]
["MHC class II antigen presentation","N67_005127","proteolysis|cysteine-type peptidase activity"," COPII-mediated vesicle transport| MHC class II antigen presentation| Cargo concentration in the ER| Neutrophil degranulation","Cathepsin C exclusion|Cathepsin C, exclusion domain superfamily|Peptidase C1A, papain C-terminal|Cysteine peptidase, histidine active site|Cysteine peptidase, asparagine active site","Cathepsin C exclusion domain|Papain family cysteine protease|Eukaryotic thiol (cysteine) proteases histidine active site.|Eukaryotic thiol (cysteine) proteases asparagine active site."]
["MHC class II antigen presentation","N67_005194","proteolysis|cysteine-type peptidase activity"," COPII-mediated vesicle transport| MHC class II antigen presentation| Cargo concentration in the ER| Neutrophil degranulation","Cysteine peptidase, cysteine active site|Peptidase C1A, papain C-terminal|Cathepsin C exclusion|Cysteine peptidase, histidine active site","Eukaryotic thiol (cysteine) proteases cysteine active site.|Papain family cysteine protease|Cathepsin C exclusion domain|Eukaryotic thiol (cysteine) proteases histidine active site."]
["FCERI mediated NF-kB activation","N67_000073","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit 3|26S proteasome regulatory subunit, C-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|Proteasome regulatory subunit C-terminal|PCI domain profile."]
["FCERI mediated NF-kB activation","N67_000266","enzyme regulator activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 6|26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1","PCI domain|PCI domain profile.|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|26S proteasome subunit RPN7"]
["FCERI mediated NF-kB activation","N67_000276","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA+ ATPase domain|ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|ATPase, AAA-type, conserved site|AAA ATPase, AAA+ lid domain|26S proteasome regulatory subunit P45-like","ATPase family associated with various cellular activities (AAA)|AAA|Proteasomal ATPase OB C-terminal domain|AAA-protein family signature.|AAA+ lid domain|26Sp45: 26S proteasome subunit P45 family"]
["FCERI mediated NF-kB activation","N67_000509","peptidase activator activity|lysine-acetylated histone binding|proteasome binding"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator complex subunit 4 C-terminal domain|Proteasome activator complex subunit 4","Domain of unknown function (DUF3437)"]
["FCERI mediated NF-kB activation","N67_000697","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome B-type subunit|Proteasome beta-type subunit, conserved site|Peptidase T1A, proteasome beta-subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|proteasome_beta_type_5|Proteasome beta-type subunit profile.|Proteasome beta-type subunits signature.|Proteasome component signature"]
["FCERI mediated NF-kB activation","N67_000728","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA ATPase, AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA+ ATPase domain|ATPase, AAA-type, conserved site|ATPase, AAA-type, core|26S proteasome regulatory subunit P45-like","AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA|AAA-protein family signature.|ATPase family associated with various cellular activities (AAA)|26Sp45: 26S proteasome subunit P45 family"]
["FCERI mediated NF-kB activation","N67_000908",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 13","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain"]
["FCERI mediated NF-kB activation","N67_001466","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit beta 2|Proteasome beta-type subunit, conserved site|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome beta-type subunits signature.|proteasome_beta_type_2|Proteasome subunit"]
["FCERI mediated NF-kB activation","N67_001507","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Hypusine synthesis from eIF5A-lysine| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S Proteasome non-ATPase regulatory subunit 1|26S proteasome regulatory subunit RPN2, C-terminal|Proteasome/cyclosome repeat|PBS lyase HEAT-like repeat|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit","26S proteasome regulatory subunit RPN2 C-terminal domain|Proteasome/cyclosome repeat|E-Z type HEAT repeats|HEAT repeats"]
["FCERI mediated NF-kB activation","N67_001583","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha 1|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|proteasome_alpha_type_1"]
["FCERI mediated NF-kB activation","N67_001700","ubiquitin-dependent protein catabolic process"," Activation of NF-kappaB in B cells| Prolactin receptor signaling| SCF-beta-TrCP mediated degradation of Emi1| Vpu mediated degradation of CD4| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| NOTCH1 Intracellular Domain Regulates Transcription| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| Circadian Clock| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| NIK-->noncanonical NF-kB signaling| MAP3K8 (TPL2)-dependent MAPK1/3 activation| Orc1 removal from chromatin| Cyclin D associated events in G1| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Regulation of RUNX2 expression and activity| Neddylation| Interleukin-1 signaling| Iron uptake and transport| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","SKP1 component, POZ domain|S-phase kinase-associated protein 1-like|S-phase kinase-associated protein 1|SKP1 component, dimerisation","Skp1 family, tetramerisation domain|BTB_POZ_SKP1|Skp1 family, dimerisation domain"]
["FCERI mediated NF-kB activation","N67_001710","protein binding|metallopeptidase activity|Lys63-specific deubiquitinase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Metalloprotease DUBs| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","MPN domain|26S Proteasome non-ATPase regulatory subunit 14|JAB1/MPN/MOV34 metalloenzyme domain|Rpn11/EIF3F, C-terminal","MPN domain profile.|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN_RPN11_CSN5|Maintenance of mitochondrial structure and function"]
["FCERI mediated NF-kB activation","N67_001726","threonine-type endopeptidase activity|proteasome core complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome subunit beta Pre3|Nucleophile aminohydrolases, N-terminal","Proteasome subunit"]
["FCERI mediated NF-kB activation","N67_001963","threonine-type endopeptidase activity|proteasome core complex|proteolysis|HslUV protease complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATP-dependent protease, HslV subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome B-type subunit","ATP_dep_HslV: ATP-dependent protease HslVU, peptidase subunit|Proteasome subunit|Proteasome beta-type subunit profile.|protease_HslV"]
["FCERI mediated NF-kB activation","N67_002329","ATP binding|cytoplasm|hydrolase activity|protein catabolic process|proteasome-activating ATPase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|26S proteasome regulatory subunit P45-like|ATPase, AAA-type, conserved site|AAA+ ATPase domain|AAA ATPase, AAA+ lid domain|26S Proteasome regulatory subunit 6B","ATPase family associated with various cellular activities (AAA)|Proteasomal ATPase OB C-terminal domain|26Sp45: 26S proteasome subunit P45 family|AAA|AAA-protein family signature.|AAA+ lid domain"]
["FCERI mediated NF-kB activation","N67_002487","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteasome core complex, beta-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta 3 subunit|Proteasome beta-type subunit, conserved site","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_3|Proteasome beta-type subunits signature."]
["FCERI mediated NF-kB activation","N67_002738","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha5|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit A N-terminal signature|Proteasome alpha-type subunits signature.|proteasome_alpha_type_5|Proteasome subunit|Proteasome alpha-type subunit profile."]
["FCERI mediated NF-kB activation","N67_002863","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Proteasome subunit alpha2","proteasome_alpha_type_2|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|Proteasome subunit"]
["FCERI mediated NF-kB activation","N67_002919",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit RPN5, C-terminal domain|26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4|Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 12|Winged helix-like DNA-binding domain superfamily","26S proteasome regulatory subunit RPN5 C-terminal domain|PCI domain profile.|PCI domain|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15"]
["FCERI mediated NF-kB activation","N67_003190","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 7|Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Peptidase T1A, proteasome beta-subunit","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_7|Proteasome beta-type subunit profile.|Proteasome component signature"]
["FCERI mediated NF-kB activation","N67_003578",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome regulatory subunit Rpn6, N-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|PCI domain profile.|26S proteasome regulatory subunit RPN6 N-terminal domain"]
["FCERI mediated NF-kB activation","N67_003579","structural constituent of ribosome|protein binding|ribosome|translation"," Translesion synthesis by REV1| Recognition of DNA damage by PCNA-containing replication complex| Translesion Synthesis by POLH| Activation of NF-kappaB in B cells| ISG15 antiviral mechanism| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants| ER-Phagosome pathway| Downregulation of ERBB4 signaling| Spry regulation of FGF signaling| Downregulation of ERBB2:ERBB3 signaling| L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| Budding and maturation of HIV virion| NOD1/2 Signaling Pathway| TICAM1, RIP1-mediated IKK complex recruitment| DDX58/IFIH1-mediated induction of interferon-alpha/beta| APC/C:Cdc20 mediated degradation of Cyclin B| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Membrane binding and targetting of GAG proteins| Assembly Of The HIV Virion| APC-Cdc20 mediated degradation of Nek2A| SRP-dependent cotranslational protein targeting to membrane| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| EGFR downregulation| SCF(Skp2)-mediated degradation of p27/p21| Viral mRNA Translation| Degradation of beta-catenin by the destruction complex| TCF dependent signaling in response to WNT| Downstream TCR signaling| NRIF signals cell death from the nucleus| p75NTR recruits signalling complexes| NF-kB is activated and signals survival| Regulation of activated PAK-2p34 by proteasome mediated degradation| NOTCH1 Intracellular Domain Regulates Transcription| Activated NOTCH1 Transmits Signal to the Nucleus| Downregulation of TGF-beta receptor signaling| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)| Downregulation of SMAD2/3:SMAD4 transcriptional activity| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription| Selenocysteine synthesis| Separation of Sister Chromatids| Oxidative Stress Induced Senescence| Senescence-Associated Secretory Phenotype (SASP)| Oncogene Induced Senescence| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Stimuli-sensing channels| Constitutive Signaling by NOTCH1 HD Domain Mutants| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| NOTCH2 Activation and Transmission of Signal to the Nucleus| Regulation of innate immune responses to cytosolic DNA| Glycogen synthesis| Autodegradation of the E3 ubiquitin ligase COP1| Deactivation of the beta-catenin transactivating complex| Myoclonic epilepsy of Lafora| ABC-family proteins mediated transport| Circadian Clock| TAK1 activates NFkB by phosphorylation and activation of IKKs complex| activated TAK1 mediates p38 MAPK activation| JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Regulation of FZD by ubiquitination| PINK1-PRKN Mediated Mitophagy| N-glycan trimming in the ER and Calnexin/Calreticulin cycle| Regulation of TNFR1 signaling| TNFR1-induced NFkappaB signaling pathway| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Negative regulation of FGFR1 signaling| Negative regulation of FGFR2 signaling| Negative regulation of FGFR3 signaling| Negative regulation of FGFR4 signaling| Translesion synthesis by POLK| Translesion synthesis by POLI| Termination of translesion DNA synthesis| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| Negative regulation of MAPK pathway| Regulation of necroptotic cell death| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAP3K8 (TPL2)-dependent MAPK1/3 activation| HDR through Homologous Recombination (HRR)| MAPK6/MAPK4 signaling| UCH proteinases| Josephin domain DUBs| Ub-specific processing proteases| Ovarian tumor domain proteases| Metalloprotease DUBs| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks| Processing of DNA double-strand break ends| DNA Damage Recognition in GG-NER| Formation of Incision Complex in GG-NER| Gap-filling DNA repair synthesis and ligation in GG-NER| Dual Incision in GG-NER| Formation of TC-NER Pre-Incision Complex| Transcription-Coupled Nucleotide Excision Repair (TC-NER)| Dual incision in TC-NER| Gap-filling DNA repair synthesis and ligation in TC-NER| Fanconi Anemia Pathway| Major pathway of rRNA processing in the nucleolus and cytosol| Regulation of TP53 Activity through Phosphorylation| Regulation of TP53 Degradation| Regulation of TP53 Activity through Methylation| Negative regulation of MET activity| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| Cyclin D associated events in G1| G2/M Checkpoints| Stabilization of p53| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Ubiquitin-dependent degradation of Cyclin D| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Cargo recognition for clathrin-mediated endocytosis| Clathrin-mediated endocytosis| Downregulation of ERBB2 signaling| Synthesis of active ubiquitin: roles of E1 and E2 enzymes| E3 ubiquitin ligases ubiquitinate target proteins| InlB-mediated entry of Listeria monocytogenes into host cell| InlA-mediated entry of Listeria monocytogenes into host cells| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN localization| Regulation of PTEN stability and activity| Neddylation| ER Quality Control Compartment (ERQC)| Regulation of expression of SLITs and ROBOs| NOTCH3 Activation and Transmission of Signal to the Nucleus| TICAM1-dependent activation of IRF3/IRF7| TICAM1,TRAF6-dependent induction of TAK1 complex| Interleukin-1 signaling| Peroxisomal protein import| Regulation of signaling by CBL| Endosomal Sorting Complex Required For Transport (ESCRT)| Iron uptake and transport| Negative regulators of DDX58/IFIH1 signaling| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon| IRAK1 recruits IKK complex| IKK complex recruitment mediated by RIP1| IRAK2 mediated activation of TAK1 complex| TRAF6-mediated induction of TAK1 complex within TLR4 complex| Negative regulation of NOTCH4 signaling| Chaperone Mediated Autophagy| Late endosomal microautophagy| Alpha-protein kinase 1 signaling pathway| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)| Amyloid fiber formation| Antigen processing: Ubiquitination & Proteasome degradation","S27a-like superfamily|Ribosomal protein S27a|Ubiquitin-like domain","Ubl_ubiquitin_like|Ribosomal protein S27a|Ubiquitin family|Ubiquitin domain profile."]
["FCERI mediated NF-kB activation","N67_003696","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core|AAA+ ATPase domain|ATPase, AAA-type, conserved site","26Sp45: 26S proteasome subunit P45 family|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA|AAA-protein family signature."]
["FCERI mediated NF-kB activation","N67_004122","proteasome regulatory particle|proteolysis"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","CSN8/PSMD8/EIF3K|Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit Rpn12","CSN8/PSMD8/EIF3K family|PCI domain profile."]
["FCERI mediated NF-kB activation","N67_004247","protein binding|proteasome regulatory particle"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S Proteasome non-ATPase regulatory subunit 7/8|JAB1/MPN/MOV34 metalloenzyme domain|MPN domain|Rpn11/EIF3F, C-terminal","MPN_RPN7_8|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN domain profile.|Maintenance of mitochondrial structure and function"]
["FCERI mediated NF-kB activation","N67_004346","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 4","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_4"]
["FCERI mediated NF-kB activation","N67_004467","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal","Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|Proteasome subunit|Proteasome subunit A N-terminal signature|proteasome_alpha_type_7"]
["FCERI mediated NF-kB activation","N67_004468","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit|Proteasome subunit A N-terminal signature|Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|proteasome_alpha_type_4"]
["FCERI mediated NF-kB activation","N67_004565","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha6|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit","proteasome_alpha_type_6|Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature"]
["FCERI mediated NF-kB activation","N67_004752","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA+ ATPase domain|ATPase, AAA-type, conserved site|Proteasomal ATPase OB C-terminal domain|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core","26Sp45: 26S proteasome subunit P45 family|AAA-protein family signature.|Proteasomal ATPase OB C-terminal domain|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA"]
["FCERI mediated NF-kB activation","N67_004822","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit|RPN1/RPN2, N-terminal|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1, C-terminal","RPN1/RPN2 N-terminal domain|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1 C-terminal"]
["FCERI mediated NF-kB activation","N67_004943","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 1|Nucleophile aminohydrolases, N-terminal","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_1|Proteasome beta-type subunits signature."]
["FCERI mediated NF-kB activation","N67_004957","protein binding|proteasome regulatory particle assembly"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","PDZ superfamily|Nas2, N-terminal|26S Proteasome non-ATPase regulatory subunit 9","Nas2 N_terminal domain"]
["FCERI mediated NF-kB activation","N67_004966","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit alpha 3|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome subunit A N-terminal signature|Proteasome subunit"]
["FCERI mediated NF-kB activation","N67_005012","proteasome activator complex"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator PA28|Proteasome activator PA28, C-terminal domain superfamily|Proteasome activator PA28, C-terminal domain","Proteasome activator pa28 beta subunit"]
["CLEC7A (Dectin-1) signaling","N67_000073","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit 3|26S proteasome regulatory subunit, C-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|Proteasome regulatory subunit C-terminal|PCI domain profile."]
["CLEC7A (Dectin-1) signaling","N67_000266","enzyme regulator activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 6|26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1","PCI domain|PCI domain profile.|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|26S proteasome subunit RPN7"]
["CLEC7A (Dectin-1) signaling","N67_000276","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA+ ATPase domain|ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|ATPase, AAA-type, conserved site|AAA ATPase, AAA+ lid domain|26S proteasome regulatory subunit P45-like","ATPase family associated with various cellular activities (AAA)|AAA|Proteasomal ATPase OB C-terminal domain|AAA-protein family signature.|AAA+ lid domain|26Sp45: 26S proteasome subunit P45 family"]
["CLEC7A (Dectin-1) signaling","N67_000509","peptidase activator activity|lysine-acetylated histone binding|proteasome binding"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator complex subunit 4 C-terminal domain|Proteasome activator complex subunit 4","Domain of unknown function (DUF3437)"]
["CLEC7A (Dectin-1) signaling","N67_000697","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome B-type subunit|Proteasome beta-type subunit, conserved site|Peptidase T1A, proteasome beta-subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|proteasome_beta_type_5|Proteasome beta-type subunit profile.|Proteasome beta-type subunits signature.|Proteasome component signature"]
["CLEC7A (Dectin-1) signaling","N67_000728","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA ATPase, AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA+ ATPase domain|ATPase, AAA-type, conserved site|ATPase, AAA-type, core|26S proteasome regulatory subunit P45-like","AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA|AAA-protein family signature.|ATPase family associated with various cellular activities (AAA)|26Sp45: 26S proteasome subunit P45 family"]
["CLEC7A (Dectin-1) signaling","N67_000908",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 13","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain"]
["CLEC7A (Dectin-1) signaling","N67_001466","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit beta 2|Proteasome beta-type subunit, conserved site|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome beta-type subunits signature.|proteasome_beta_type_2|Proteasome subunit"]
["CLEC7A (Dectin-1) signaling","N67_001507","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Hypusine synthesis from eIF5A-lysine| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S Proteasome non-ATPase regulatory subunit 1|26S proteasome regulatory subunit RPN2, C-terminal|Proteasome/cyclosome repeat|PBS lyase HEAT-like repeat|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit","26S proteasome regulatory subunit RPN2 C-terminal domain|Proteasome/cyclosome repeat|E-Z type HEAT repeats|HEAT repeats"]
["CLEC7A (Dectin-1) signaling","N67_001583","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha 1|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|proteasome_alpha_type_1"]
["CLEC7A (Dectin-1) signaling","N67_001700","ubiquitin-dependent protein catabolic process"," Activation of NF-kappaB in B cells| Prolactin receptor signaling| SCF-beta-TrCP mediated degradation of Emi1| Vpu mediated degradation of CD4| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| NOTCH1 Intracellular Domain Regulates Transcription| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| Circadian Clock| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| NIK-->noncanonical NF-kB signaling| MAP3K8 (TPL2)-dependent MAPK1/3 activation| Orc1 removal from chromatin| Cyclin D associated events in G1| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Regulation of RUNX2 expression and activity| Neddylation| Interleukin-1 signaling| Iron uptake and transport| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","SKP1 component, POZ domain|S-phase kinase-associated protein 1-like|S-phase kinase-associated protein 1|SKP1 component, dimerisation","Skp1 family, tetramerisation domain|BTB_POZ_SKP1|Skp1 family, dimerisation domain"]
["CLEC7A (Dectin-1) signaling","N67_001710","protein binding|metallopeptidase activity|Lys63-specific deubiquitinase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Metalloprotease DUBs| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","MPN domain|26S Proteasome non-ATPase regulatory subunit 14|JAB1/MPN/MOV34 metalloenzyme domain|Rpn11/EIF3F, C-terminal","MPN domain profile.|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN_RPN11_CSN5|Maintenance of mitochondrial structure and function"]
["CLEC7A (Dectin-1) signaling","N67_001726","threonine-type endopeptidase activity|proteasome core complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome subunit beta Pre3|Nucleophile aminohydrolases, N-terminal","Proteasome subunit"]
["CLEC7A (Dectin-1) signaling","N67_001963","threonine-type endopeptidase activity|proteasome core complex|proteolysis|HslUV protease complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATP-dependent protease, HslV subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome B-type subunit","ATP_dep_HslV: ATP-dependent protease HslVU, peptidase subunit|Proteasome subunit|Proteasome beta-type subunit profile.|protease_HslV"]
["CLEC7A (Dectin-1) signaling","N67_002329","ATP binding|cytoplasm|hydrolase activity|protein catabolic process|proteasome-activating ATPase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|26S proteasome regulatory subunit P45-like|ATPase, AAA-type, conserved site|AAA+ ATPase domain|AAA ATPase, AAA+ lid domain|26S Proteasome regulatory subunit 6B","ATPase family associated with various cellular activities (AAA)|Proteasomal ATPase OB C-terminal domain|26Sp45: 26S proteasome subunit P45 family|AAA|AAA-protein family signature.|AAA+ lid domain"]
["CLEC7A (Dectin-1) signaling","N67_002487","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteasome core complex, beta-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta 3 subunit|Proteasome beta-type subunit, conserved site","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_3|Proteasome beta-type subunits signature."]
["CLEC7A (Dectin-1) signaling","N67_002738","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha5|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit A N-terminal signature|Proteasome alpha-type subunits signature.|proteasome_alpha_type_5|Proteasome subunit|Proteasome alpha-type subunit profile."]
["CLEC7A (Dectin-1) signaling","N67_002863","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Proteasome subunit alpha2","proteasome_alpha_type_2|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|Proteasome subunit"]
["CLEC7A (Dectin-1) signaling","N67_002919",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit RPN5, C-terminal domain|26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4|Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 12|Winged helix-like DNA-binding domain superfamily","26S proteasome regulatory subunit RPN5 C-terminal domain|PCI domain profile.|PCI domain|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15"]
["CLEC7A (Dectin-1) signaling","N67_003190","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 7|Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Peptidase T1A, proteasome beta-subunit","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_7|Proteasome beta-type subunit profile.|Proteasome component signature"]
["CLEC7A (Dectin-1) signaling","N67_003578",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome regulatory subunit Rpn6, N-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|PCI domain profile.|26S proteasome regulatory subunit RPN6 N-terminal domain"]
["CLEC7A (Dectin-1) signaling","N67_003579","structural constituent of ribosome|protein binding|ribosome|translation"," Translesion synthesis by REV1| Recognition of DNA damage by PCNA-containing replication complex| Translesion Synthesis by POLH| Activation of NF-kappaB in B cells| ISG15 antiviral mechanism| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants| ER-Phagosome pathway| Downregulation of ERBB4 signaling| Spry regulation of FGF signaling| Downregulation of ERBB2:ERBB3 signaling| L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| Budding and maturation of HIV virion| NOD1/2 Signaling Pathway| TICAM1, RIP1-mediated IKK complex recruitment| DDX58/IFIH1-mediated induction of interferon-alpha/beta| APC/C:Cdc20 mediated degradation of Cyclin B| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Membrane binding and targetting of GAG proteins| Assembly Of The HIV Virion| APC-Cdc20 mediated degradation of Nek2A| SRP-dependent cotranslational protein targeting to membrane| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| EGFR downregulation| SCF(Skp2)-mediated degradation of p27/p21| Viral mRNA Translation| Degradation of beta-catenin by the destruction complex| TCF dependent signaling in response to WNT| Downstream TCR signaling| NRIF signals cell death from the nucleus| p75NTR recruits signalling complexes| NF-kB is activated and signals survival| Regulation of activated PAK-2p34 by proteasome mediated degradation| NOTCH1 Intracellular Domain Regulates Transcription| Activated NOTCH1 Transmits Signal to the Nucleus| Downregulation of TGF-beta receptor signaling| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)| Downregulation of SMAD2/3:SMAD4 transcriptional activity| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription| Selenocysteine synthesis| Separation of Sister Chromatids| Oxidative Stress Induced Senescence| Senescence-Associated Secretory Phenotype (SASP)| Oncogene Induced Senescence| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Stimuli-sensing channels| Constitutive Signaling by NOTCH1 HD Domain Mutants| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| NOTCH2 Activation and Transmission of Signal to the Nucleus| Regulation of innate immune responses to cytosolic DNA| Glycogen synthesis| Autodegradation of the E3 ubiquitin ligase COP1| Deactivation of the beta-catenin transactivating complex| Myoclonic epilepsy of Lafora| ABC-family proteins mediated transport| Circadian Clock| TAK1 activates NFkB by phosphorylation and activation of IKKs complex| activated TAK1 mediates p38 MAPK activation| JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Regulation of FZD by ubiquitination| PINK1-PRKN Mediated Mitophagy| N-glycan trimming in the ER and Calnexin/Calreticulin cycle| Regulation of TNFR1 signaling| TNFR1-induced NFkappaB signaling pathway| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Negative regulation of FGFR1 signaling| Negative regulation of FGFR2 signaling| Negative regulation of FGFR3 signaling| Negative regulation of FGFR4 signaling| Translesion synthesis by POLK| Translesion synthesis by POLI| Termination of translesion DNA synthesis| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| Negative regulation of MAPK pathway| Regulation of necroptotic cell death| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAP3K8 (TPL2)-dependent MAPK1/3 activation| HDR through Homologous Recombination (HRR)| MAPK6/MAPK4 signaling| UCH proteinases| Josephin domain DUBs| Ub-specific processing proteases| Ovarian tumor domain proteases| Metalloprotease DUBs| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks| Processing of DNA double-strand break ends| DNA Damage Recognition in GG-NER| Formation of Incision Complex in GG-NER| Gap-filling DNA repair synthesis and ligation in GG-NER| Dual Incision in GG-NER| Formation of TC-NER Pre-Incision Complex| Transcription-Coupled Nucleotide Excision Repair (TC-NER)| Dual incision in TC-NER| Gap-filling DNA repair synthesis and ligation in TC-NER| Fanconi Anemia Pathway| Major pathway of rRNA processing in the nucleolus and cytosol| Regulation of TP53 Activity through Phosphorylation| Regulation of TP53 Degradation| Regulation of TP53 Activity through Methylation| Negative regulation of MET activity| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| Cyclin D associated events in G1| G2/M Checkpoints| Stabilization of p53| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Ubiquitin-dependent degradation of Cyclin D| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Cargo recognition for clathrin-mediated endocytosis| Clathrin-mediated endocytosis| Downregulation of ERBB2 signaling| Synthesis of active ubiquitin: roles of E1 and E2 enzymes| E3 ubiquitin ligases ubiquitinate target proteins| InlB-mediated entry of Listeria monocytogenes into host cell| InlA-mediated entry of Listeria monocytogenes into host cells| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN localization| Regulation of PTEN stability and activity| Neddylation| ER Quality Control Compartment (ERQC)| Regulation of expression of SLITs and ROBOs| NOTCH3 Activation and Transmission of Signal to the Nucleus| TICAM1-dependent activation of IRF3/IRF7| TICAM1,TRAF6-dependent induction of TAK1 complex| Interleukin-1 signaling| Peroxisomal protein import| Regulation of signaling by CBL| Endosomal Sorting Complex Required For Transport (ESCRT)| Iron uptake and transport| Negative regulators of DDX58/IFIH1 signaling| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon| IRAK1 recruits IKK complex| IKK complex recruitment mediated by RIP1| IRAK2 mediated activation of TAK1 complex| TRAF6-mediated induction of TAK1 complex within TLR4 complex| Negative regulation of NOTCH4 signaling| Chaperone Mediated Autophagy| Late endosomal microautophagy| Alpha-protein kinase 1 signaling pathway| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)| Amyloid fiber formation| Antigen processing: Ubiquitination & Proteasome degradation","S27a-like superfamily|Ribosomal protein S27a|Ubiquitin-like domain","Ubl_ubiquitin_like|Ribosomal protein S27a|Ubiquitin family|Ubiquitin domain profile."]
["CLEC7A (Dectin-1) signaling","N67_003696","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core|AAA+ ATPase domain|ATPase, AAA-type, conserved site","26Sp45: 26S proteasome subunit P45 family|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA|AAA-protein family signature."]
["CLEC7A (Dectin-1) signaling","N67_004122","proteasome regulatory particle|proteolysis"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","CSN8/PSMD8/EIF3K|Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit Rpn12","CSN8/PSMD8/EIF3K family|PCI domain profile."]
["CLEC7A (Dectin-1) signaling","N67_004247","protein binding|proteasome regulatory particle"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S Proteasome non-ATPase regulatory subunit 7/8|JAB1/MPN/MOV34 metalloenzyme domain|MPN domain|Rpn11/EIF3F, C-terminal","MPN_RPN7_8|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN domain profile.|Maintenance of mitochondrial structure and function"]
["CLEC7A (Dectin-1) signaling","N67_004346","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 4","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_4"]
["CLEC7A (Dectin-1) signaling","N67_004467","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal","Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|Proteasome subunit|Proteasome subunit A N-terminal signature|proteasome_alpha_type_7"]
["CLEC7A (Dectin-1) signaling","N67_004468","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit|Proteasome subunit A N-terminal signature|Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|proteasome_alpha_type_4"]
["CLEC7A (Dectin-1) signaling","N67_004565","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha6|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit","proteasome_alpha_type_6|Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature"]
["CLEC7A (Dectin-1) signaling","N67_004752","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA+ ATPase domain|ATPase, AAA-type, conserved site|Proteasomal ATPase OB C-terminal domain|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core","26Sp45: 26S proteasome subunit P45 family|AAA-protein family signature.|Proteasomal ATPase OB C-terminal domain|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA"]
["CLEC7A (Dectin-1) signaling","N67_004822","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit|RPN1/RPN2, N-terminal|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1, C-terminal","RPN1/RPN2 N-terminal domain|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1 C-terminal"]
["CLEC7A (Dectin-1) signaling","N67_004943","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 1|Nucleophile aminohydrolases, N-terminal","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_1|Proteasome beta-type subunits signature."]
["CLEC7A (Dectin-1) signaling","N67_004957","protein binding|proteasome regulatory particle assembly"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","PDZ superfamily|Nas2, N-terminal|26S Proteasome non-ATPase regulatory subunit 9","Nas2 N_terminal domain"]
["CLEC7A (Dectin-1) signaling","N67_004966","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit alpha 3|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome subunit A N-terminal signature|Proteasome subunit"]
["CLEC7A (Dectin-1) signaling","N67_005012","proteasome activator complex"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator PA28|Proteasome activator PA28, C-terminal domain superfamily|Proteasome activator PA28, C-terminal domain","Proteasome activator pa28 beta subunit"]
["TNFR2 non-canonical NF-kB pathway","N67_000073","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit 3|26S proteasome regulatory subunit, C-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|Proteasome regulatory subunit C-terminal|PCI domain profile."]
["TNFR2 non-canonical NF-kB pathway","N67_000266","enzyme regulator activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 6|26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1","PCI domain|PCI domain profile.|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|26S proteasome subunit RPN7"]
["TNFR2 non-canonical NF-kB pathway","N67_000276","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA+ ATPase domain|ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|ATPase, AAA-type, conserved site|AAA ATPase, AAA+ lid domain|26S proteasome regulatory subunit P45-like","ATPase family associated with various cellular activities (AAA)|AAA|Proteasomal ATPase OB C-terminal domain|AAA-protein family signature.|AAA+ lid domain|26Sp45: 26S proteasome subunit P45 family"]
["TNFR2 non-canonical NF-kB pathway","N67_000509","peptidase activator activity|lysine-acetylated histone binding|proteasome binding"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator complex subunit 4 C-terminal domain|Proteasome activator complex subunit 4","Domain of unknown function (DUF3437)"]
["TNFR2 non-canonical NF-kB pathway","N67_000697","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome B-type subunit|Proteasome beta-type subunit, conserved site|Peptidase T1A, proteasome beta-subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|proteasome_beta_type_5|Proteasome beta-type subunit profile.|Proteasome beta-type subunits signature.|Proteasome component signature"]
["TNFR2 non-canonical NF-kB pathway","N67_000728","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA ATPase, AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA+ ATPase domain|ATPase, AAA-type, conserved site|ATPase, AAA-type, core|26S proteasome regulatory subunit P45-like","AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA|AAA-protein family signature.|ATPase family associated with various cellular activities (AAA)|26Sp45: 26S proteasome subunit P45 family"]
["TNFR2 non-canonical NF-kB pathway","N67_000908",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 13","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain"]
["TNFR2 non-canonical NF-kB pathway","N67_001466","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit beta 2|Proteasome beta-type subunit, conserved site|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome beta-type subunits signature.|proteasome_beta_type_2|Proteasome subunit"]
["TNFR2 non-canonical NF-kB pathway","N67_001507","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Hypusine synthesis from eIF5A-lysine| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S Proteasome non-ATPase regulatory subunit 1|26S proteasome regulatory subunit RPN2, C-terminal|Proteasome/cyclosome repeat|PBS lyase HEAT-like repeat|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit","26S proteasome regulatory subunit RPN2 C-terminal domain|Proteasome/cyclosome repeat|E-Z type HEAT repeats|HEAT repeats"]
["TNFR2 non-canonical NF-kB pathway","N67_001583","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha 1|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|proteasome_alpha_type_1"]
["TNFR2 non-canonical NF-kB pathway","N67_001710","protein binding|metallopeptidase activity|Lys63-specific deubiquitinase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Metalloprotease DUBs| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","MPN domain|26S Proteasome non-ATPase regulatory subunit 14|JAB1/MPN/MOV34 metalloenzyme domain|Rpn11/EIF3F, C-terminal","MPN domain profile.|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN_RPN11_CSN5|Maintenance of mitochondrial structure and function"]
["TNFR2 non-canonical NF-kB pathway","N67_001726","threonine-type endopeptidase activity|proteasome core complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome subunit beta Pre3|Nucleophile aminohydrolases, N-terminal","Proteasome subunit"]
["TNFR2 non-canonical NF-kB pathway","N67_001963","threonine-type endopeptidase activity|proteasome core complex|proteolysis|HslUV protease complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATP-dependent protease, HslV subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome B-type subunit","ATP_dep_HslV: ATP-dependent protease HslVU, peptidase subunit|Proteasome subunit|Proteasome beta-type subunit profile.|protease_HslV"]
["TNFR2 non-canonical NF-kB pathway","N67_002329","ATP binding|cytoplasm|hydrolase activity|protein catabolic process|proteasome-activating ATPase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|26S proteasome regulatory subunit P45-like|ATPase, AAA-type, conserved site|AAA+ ATPase domain|AAA ATPase, AAA+ lid domain|26S Proteasome regulatory subunit 6B","ATPase family associated with various cellular activities (AAA)|Proteasomal ATPase OB C-terminal domain|26Sp45: 26S proteasome subunit P45 family|AAA|AAA-protein family signature.|AAA+ lid domain"]
["TNFR2 non-canonical NF-kB pathway","N67_002487","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteasome core complex, beta-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta 3 subunit|Proteasome beta-type subunit, conserved site","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_3|Proteasome beta-type subunits signature."]
["TNFR2 non-canonical NF-kB pathway","N67_002738","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha5|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit A N-terminal signature|Proteasome alpha-type subunits signature.|proteasome_alpha_type_5|Proteasome subunit|Proteasome alpha-type subunit profile."]
["TNFR2 non-canonical NF-kB pathway","N67_002863","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Proteasome subunit alpha2","proteasome_alpha_type_2|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|Proteasome subunit"]
["TNFR2 non-canonical NF-kB pathway","N67_002919",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit RPN5, C-terminal domain|26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4|Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 12|Winged helix-like DNA-binding domain superfamily","26S proteasome regulatory subunit RPN5 C-terminal domain|PCI domain profile.|PCI domain|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15"]
["TNFR2 non-canonical NF-kB pathway","N67_003190","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 7|Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Peptidase T1A, proteasome beta-subunit","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_7|Proteasome beta-type subunit profile.|Proteasome component signature"]
["TNFR2 non-canonical NF-kB pathway","N67_003578",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome regulatory subunit Rpn6, N-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|PCI domain profile.|26S proteasome regulatory subunit RPN6 N-terminal domain"]
["TNFR2 non-canonical NF-kB pathway","N67_003579","structural constituent of ribosome|protein binding|ribosome|translation"," Translesion synthesis by REV1| Recognition of DNA damage by PCNA-containing replication complex| Translesion Synthesis by POLH| Activation of NF-kappaB in B cells| ISG15 antiviral mechanism| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants| ER-Phagosome pathway| Downregulation of ERBB4 signaling| Spry regulation of FGF signaling| Downregulation of ERBB2:ERBB3 signaling| L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| Budding and maturation of HIV virion| NOD1/2 Signaling Pathway| TICAM1, RIP1-mediated IKK complex recruitment| DDX58/IFIH1-mediated induction of interferon-alpha/beta| APC/C:Cdc20 mediated degradation of Cyclin B| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Membrane binding and targetting of GAG proteins| Assembly Of The HIV Virion| APC-Cdc20 mediated degradation of Nek2A| SRP-dependent cotranslational protein targeting to membrane| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| EGFR downregulation| SCF(Skp2)-mediated degradation of p27/p21| Viral mRNA Translation| Degradation of beta-catenin by the destruction complex| TCF dependent signaling in response to WNT| Downstream TCR signaling| NRIF signals cell death from the nucleus| p75NTR recruits signalling complexes| NF-kB is activated and signals survival| Regulation of activated PAK-2p34 by proteasome mediated degradation| NOTCH1 Intracellular Domain Regulates Transcription| Activated NOTCH1 Transmits Signal to the Nucleus| Downregulation of TGF-beta receptor signaling| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)| Downregulation of SMAD2/3:SMAD4 transcriptional activity| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription| Selenocysteine synthesis| Separation of Sister Chromatids| Oxidative Stress Induced Senescence| Senescence-Associated Secretory Phenotype (SASP)| Oncogene Induced Senescence| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Stimuli-sensing channels| Constitutive Signaling by NOTCH1 HD Domain Mutants| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| NOTCH2 Activation and Transmission of Signal to the Nucleus| Regulation of innate immune responses to cytosolic DNA| Glycogen synthesis| Autodegradation of the E3 ubiquitin ligase COP1| Deactivation of the beta-catenin transactivating complex| Myoclonic epilepsy of Lafora| ABC-family proteins mediated transport| Circadian Clock| TAK1 activates NFkB by phosphorylation and activation of IKKs complex| activated TAK1 mediates p38 MAPK activation| JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Regulation of FZD by ubiquitination| PINK1-PRKN Mediated Mitophagy| N-glycan trimming in the ER and Calnexin/Calreticulin cycle| Regulation of TNFR1 signaling| TNFR1-induced NFkappaB signaling pathway| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Negative regulation of FGFR1 signaling| Negative regulation of FGFR2 signaling| Negative regulation of FGFR3 signaling| Negative regulation of FGFR4 signaling| Translesion synthesis by POLK| Translesion synthesis by POLI| Termination of translesion DNA synthesis| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| Negative regulation of MAPK pathway| Regulation of necroptotic cell death| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAP3K8 (TPL2)-dependent MAPK1/3 activation| HDR through Homologous Recombination (HRR)| MAPK6/MAPK4 signaling| UCH proteinases| Josephin domain DUBs| Ub-specific processing proteases| Ovarian tumor domain proteases| Metalloprotease DUBs| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks| Processing of DNA double-strand break ends| DNA Damage Recognition in GG-NER| Formation of Incision Complex in GG-NER| Gap-filling DNA repair synthesis and ligation in GG-NER| Dual Incision in GG-NER| Formation of TC-NER Pre-Incision Complex| Transcription-Coupled Nucleotide Excision Repair (TC-NER)| Dual incision in TC-NER| Gap-filling DNA repair synthesis and ligation in TC-NER| Fanconi Anemia Pathway| Major pathway of rRNA processing in the nucleolus and cytosol| Regulation of TP53 Activity through Phosphorylation| Regulation of TP53 Degradation| Regulation of TP53 Activity through Methylation| Negative regulation of MET activity| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| Cyclin D associated events in G1| G2/M Checkpoints| Stabilization of p53| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Ubiquitin-dependent degradation of Cyclin D| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Cargo recognition for clathrin-mediated endocytosis| Clathrin-mediated endocytosis| Downregulation of ERBB2 signaling| Synthesis of active ubiquitin: roles of E1 and E2 enzymes| E3 ubiquitin ligases ubiquitinate target proteins| InlB-mediated entry of Listeria monocytogenes into host cell| InlA-mediated entry of Listeria monocytogenes into host cells| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN localization| Regulation of PTEN stability and activity| Neddylation| ER Quality Control Compartment (ERQC)| Regulation of expression of SLITs and ROBOs| NOTCH3 Activation and Transmission of Signal to the Nucleus| TICAM1-dependent activation of IRF3/IRF7| TICAM1,TRAF6-dependent induction of TAK1 complex| Interleukin-1 signaling| Peroxisomal protein import| Regulation of signaling by CBL| Endosomal Sorting Complex Required For Transport (ESCRT)| Iron uptake and transport| Negative regulators of DDX58/IFIH1 signaling| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon| IRAK1 recruits IKK complex| IKK complex recruitment mediated by RIP1| IRAK2 mediated activation of TAK1 complex| TRAF6-mediated induction of TAK1 complex within TLR4 complex| Negative regulation of NOTCH4 signaling| Chaperone Mediated Autophagy| Late endosomal microautophagy| Alpha-protein kinase 1 signaling pathway| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)| Amyloid fiber formation| Antigen processing: Ubiquitination & Proteasome degradation","S27a-like superfamily|Ribosomal protein S27a|Ubiquitin-like domain","Ubl_ubiquitin_like|Ribosomal protein S27a|Ubiquitin family|Ubiquitin domain profile."]
["TNFR2 non-canonical NF-kB pathway","N67_003696","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core|AAA+ ATPase domain|ATPase, AAA-type, conserved site","26Sp45: 26S proteasome subunit P45 family|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA|AAA-protein family signature."]
["TNFR2 non-canonical NF-kB pathway","N67_004122","proteasome regulatory particle|proteolysis"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","CSN8/PSMD8/EIF3K|Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit Rpn12","CSN8/PSMD8/EIF3K family|PCI domain profile."]
["TNFR2 non-canonical NF-kB pathway","N67_004247","protein binding|proteasome regulatory particle"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S Proteasome non-ATPase regulatory subunit 7/8|JAB1/MPN/MOV34 metalloenzyme domain|MPN domain|Rpn11/EIF3F, C-terminal","MPN_RPN7_8|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN domain profile.|Maintenance of mitochondrial structure and function"]
["TNFR2 non-canonical NF-kB pathway","N67_004346","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 4","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_4"]
["TNFR2 non-canonical NF-kB pathway","N67_004467","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal","Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|Proteasome subunit|Proteasome subunit A N-terminal signature|proteasome_alpha_type_7"]
["TNFR2 non-canonical NF-kB pathway","N67_004468","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit|Proteasome subunit A N-terminal signature|Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|proteasome_alpha_type_4"]
["TNFR2 non-canonical NF-kB pathway","N67_004565","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha6|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit","proteasome_alpha_type_6|Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature"]
["TNFR2 non-canonical NF-kB pathway","N67_004752","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA+ ATPase domain|ATPase, AAA-type, conserved site|Proteasomal ATPase OB C-terminal domain|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core","26Sp45: 26S proteasome subunit P45 family|AAA-protein family signature.|Proteasomal ATPase OB C-terminal domain|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA"]
["TNFR2 non-canonical NF-kB pathway","N67_004822","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit|RPN1/RPN2, N-terminal|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1, C-terminal","RPN1/RPN2 N-terminal domain|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1 C-terminal"]
["TNFR2 non-canonical NF-kB pathway","N67_004943","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 1|Nucleophile aminohydrolases, N-terminal","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_1|Proteasome beta-type subunits signature."]
["TNFR2 non-canonical NF-kB pathway","N67_004957","protein binding|proteasome regulatory particle assembly"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","PDZ superfamily|Nas2, N-terminal|26S Proteasome non-ATPase regulatory subunit 9","Nas2 N_terminal domain"]
["TNFR2 non-canonical NF-kB pathway","N67_004966","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit alpha 3|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome subunit A N-terminal signature|Proteasome subunit"]
["TNFR2 non-canonical NF-kB pathway","N67_005012","proteasome activator complex"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator PA28|Proteasome activator PA28, C-terminal domain superfamily|Proteasome activator PA28, C-terminal domain","Proteasome activator pa28 beta subunit"]
["NIK-->noncanonical NF-kB signaling","N67_000073","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit 3|26S proteasome regulatory subunit, C-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|Proteasome regulatory subunit C-terminal|PCI domain profile."]
["NIK-->noncanonical NF-kB signaling","N67_000266","enzyme regulator activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 6|26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1","PCI domain|PCI domain profile.|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|26S proteasome subunit RPN7"]
["NIK-->noncanonical NF-kB signaling","N67_000276","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA+ ATPase domain|ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|ATPase, AAA-type, conserved site|AAA ATPase, AAA+ lid domain|26S proteasome regulatory subunit P45-like","ATPase family associated with various cellular activities (AAA)|AAA|Proteasomal ATPase OB C-terminal domain|AAA-protein family signature.|AAA+ lid domain|26Sp45: 26S proteasome subunit P45 family"]
["NIK-->noncanonical NF-kB signaling","N67_000509","peptidase activator activity|lysine-acetylated histone binding|proteasome binding"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator complex subunit 4 C-terminal domain|Proteasome activator complex subunit 4","Domain of unknown function (DUF3437)"]
["NIK-->noncanonical NF-kB signaling","N67_000697","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome B-type subunit|Proteasome beta-type subunit, conserved site|Peptidase T1A, proteasome beta-subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|proteasome_beta_type_5|Proteasome beta-type subunit profile.|Proteasome beta-type subunits signature.|Proteasome component signature"]
["NIK-->noncanonical NF-kB signaling","N67_000728","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA ATPase, AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA+ ATPase domain|ATPase, AAA-type, conserved site|ATPase, AAA-type, core|26S proteasome regulatory subunit P45-like","AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA|AAA-protein family signature.|ATPase family associated with various cellular activities (AAA)|26Sp45: 26S proteasome subunit P45 family"]
["NIK-->noncanonical NF-kB signaling","N67_000908",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 13","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain"]
["NIK-->noncanonical NF-kB signaling","N67_001466","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit beta 2|Proteasome beta-type subunit, conserved site|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome beta-type subunits signature.|proteasome_beta_type_2|Proteasome subunit"]
["NIK-->noncanonical NF-kB signaling","N67_001507","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Hypusine synthesis from eIF5A-lysine| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S Proteasome non-ATPase regulatory subunit 1|26S proteasome regulatory subunit RPN2, C-terminal|Proteasome/cyclosome repeat|PBS lyase HEAT-like repeat|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit","26S proteasome regulatory subunit RPN2 C-terminal domain|Proteasome/cyclosome repeat|E-Z type HEAT repeats|HEAT repeats"]
["NIK-->noncanonical NF-kB signaling","N67_001583","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha 1|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|proteasome_alpha_type_1"]
["NIK-->noncanonical NF-kB signaling","N67_001700","ubiquitin-dependent protein catabolic process"," Activation of NF-kappaB in B cells| Prolactin receptor signaling| SCF-beta-TrCP mediated degradation of Emi1| Vpu mediated degradation of CD4| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| NOTCH1 Intracellular Domain Regulates Transcription| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| Circadian Clock| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| NIK-->noncanonical NF-kB signaling| MAP3K8 (TPL2)-dependent MAPK1/3 activation| Orc1 removal from chromatin| Cyclin D associated events in G1| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Regulation of RUNX2 expression and activity| Neddylation| Interleukin-1 signaling| Iron uptake and transport| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","SKP1 component, POZ domain|S-phase kinase-associated protein 1-like|S-phase kinase-associated protein 1|SKP1 component, dimerisation","Skp1 family, tetramerisation domain|BTB_POZ_SKP1|Skp1 family, dimerisation domain"]
["NIK-->noncanonical NF-kB signaling","N67_001710","protein binding|metallopeptidase activity|Lys63-specific deubiquitinase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Metalloprotease DUBs| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","MPN domain|26S Proteasome non-ATPase regulatory subunit 14|JAB1/MPN/MOV34 metalloenzyme domain|Rpn11/EIF3F, C-terminal","MPN domain profile.|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN_RPN11_CSN5|Maintenance of mitochondrial structure and function"]
["NIK-->noncanonical NF-kB signaling","N67_001726","threonine-type endopeptidase activity|proteasome core complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome subunit beta Pre3|Nucleophile aminohydrolases, N-terminal","Proteasome subunit"]
["NIK-->noncanonical NF-kB signaling","N67_001963","threonine-type endopeptidase activity|proteasome core complex|proteolysis|HslUV protease complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATP-dependent protease, HslV subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome B-type subunit","ATP_dep_HslV: ATP-dependent protease HslVU, peptidase subunit|Proteasome subunit|Proteasome beta-type subunit profile.|protease_HslV"]
["NIK-->noncanonical NF-kB signaling","N67_002329","ATP binding|cytoplasm|hydrolase activity|protein catabolic process|proteasome-activating ATPase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|26S proteasome regulatory subunit P45-like|ATPase, AAA-type, conserved site|AAA+ ATPase domain|AAA ATPase, AAA+ lid domain|26S Proteasome regulatory subunit 6B","ATPase family associated with various cellular activities (AAA)|Proteasomal ATPase OB C-terminal domain|26Sp45: 26S proteasome subunit P45 family|AAA|AAA-protein family signature.|AAA+ lid domain"]
["NIK-->noncanonical NF-kB signaling","N67_002487","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteasome core complex, beta-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta 3 subunit|Proteasome beta-type subunit, conserved site","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_3|Proteasome beta-type subunits signature."]
["NIK-->noncanonical NF-kB signaling","N67_002738","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha5|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit A N-terminal signature|Proteasome alpha-type subunits signature.|proteasome_alpha_type_5|Proteasome subunit|Proteasome alpha-type subunit profile."]
["NIK-->noncanonical NF-kB signaling","N67_002863","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Proteasome subunit alpha2","proteasome_alpha_type_2|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|Proteasome subunit"]
["NIK-->noncanonical NF-kB signaling","N67_002919",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit RPN5, C-terminal domain|26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4|Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 12|Winged helix-like DNA-binding domain superfamily","26S proteasome regulatory subunit RPN5 C-terminal domain|PCI domain profile.|PCI domain|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15"]
["NIK-->noncanonical NF-kB signaling","N67_003190","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 7|Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Peptidase T1A, proteasome beta-subunit","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_7|Proteasome beta-type subunit profile.|Proteasome component signature"]
["NIK-->noncanonical NF-kB signaling","N67_003578",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome regulatory subunit Rpn6, N-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|PCI domain profile.|26S proteasome regulatory subunit RPN6 N-terminal domain"]
["NIK-->noncanonical NF-kB signaling","N67_003579","structural constituent of ribosome|protein binding|ribosome|translation"," Translesion synthesis by REV1| Recognition of DNA damage by PCNA-containing replication complex| Translesion Synthesis by POLH| Activation of NF-kappaB in B cells| ISG15 antiviral mechanism| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants| ER-Phagosome pathway| Downregulation of ERBB4 signaling| Spry regulation of FGF signaling| Downregulation of ERBB2:ERBB3 signaling| L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| Budding and maturation of HIV virion| NOD1/2 Signaling Pathway| TICAM1, RIP1-mediated IKK complex recruitment| DDX58/IFIH1-mediated induction of interferon-alpha/beta| APC/C:Cdc20 mediated degradation of Cyclin B| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Membrane binding and targetting of GAG proteins| Assembly Of The HIV Virion| APC-Cdc20 mediated degradation of Nek2A| SRP-dependent cotranslational protein targeting to membrane| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| EGFR downregulation| SCF(Skp2)-mediated degradation of p27/p21| Viral mRNA Translation| Degradation of beta-catenin by the destruction complex| TCF dependent signaling in response to WNT| Downstream TCR signaling| NRIF signals cell death from the nucleus| p75NTR recruits signalling complexes| NF-kB is activated and signals survival| Regulation of activated PAK-2p34 by proteasome mediated degradation| NOTCH1 Intracellular Domain Regulates Transcription| Activated NOTCH1 Transmits Signal to the Nucleus| Downregulation of TGF-beta receptor signaling| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)| Downregulation of SMAD2/3:SMAD4 transcriptional activity| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription| Selenocysteine synthesis| Separation of Sister Chromatids| Oxidative Stress Induced Senescence| Senescence-Associated Secretory Phenotype (SASP)| Oncogene Induced Senescence| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Stimuli-sensing channels| Constitutive Signaling by NOTCH1 HD Domain Mutants| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| NOTCH2 Activation and Transmission of Signal to the Nucleus| Regulation of innate immune responses to cytosolic DNA| Glycogen synthesis| Autodegradation of the E3 ubiquitin ligase COP1| Deactivation of the beta-catenin transactivating complex| Myoclonic epilepsy of Lafora| ABC-family proteins mediated transport| Circadian Clock| TAK1 activates NFkB by phosphorylation and activation of IKKs complex| activated TAK1 mediates p38 MAPK activation| JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Regulation of FZD by ubiquitination| PINK1-PRKN Mediated Mitophagy| N-glycan trimming in the ER and Calnexin/Calreticulin cycle| Regulation of TNFR1 signaling| TNFR1-induced NFkappaB signaling pathway| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Negative regulation of FGFR1 signaling| Negative regulation of FGFR2 signaling| Negative regulation of FGFR3 signaling| Negative regulation of FGFR4 signaling| Translesion synthesis by POLK| Translesion synthesis by POLI| Termination of translesion DNA synthesis| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| Negative regulation of MAPK pathway| Regulation of necroptotic cell death| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAP3K8 (TPL2)-dependent MAPK1/3 activation| HDR through Homologous Recombination (HRR)| MAPK6/MAPK4 signaling| UCH proteinases| Josephin domain DUBs| Ub-specific processing proteases| Ovarian tumor domain proteases| Metalloprotease DUBs| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks| Processing of DNA double-strand break ends| DNA Damage Recognition in GG-NER| Formation of Incision Complex in GG-NER| Gap-filling DNA repair synthesis and ligation in GG-NER| Dual Incision in GG-NER| Formation of TC-NER Pre-Incision Complex| Transcription-Coupled Nucleotide Excision Repair (TC-NER)| Dual incision in TC-NER| Gap-filling DNA repair synthesis and ligation in TC-NER| Fanconi Anemia Pathway| Major pathway of rRNA processing in the nucleolus and cytosol| Regulation of TP53 Activity through Phosphorylation| Regulation of TP53 Degradation| Regulation of TP53 Activity through Methylation| Negative regulation of MET activity| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| Cyclin D associated events in G1| G2/M Checkpoints| Stabilization of p53| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Ubiquitin-dependent degradation of Cyclin D| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Cargo recognition for clathrin-mediated endocytosis| Clathrin-mediated endocytosis| Downregulation of ERBB2 signaling| Synthesis of active ubiquitin: roles of E1 and E2 enzymes| E3 ubiquitin ligases ubiquitinate target proteins| InlB-mediated entry of Listeria monocytogenes into host cell| InlA-mediated entry of Listeria monocytogenes into host cells| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN localization| Regulation of PTEN stability and activity| Neddylation| ER Quality Control Compartment (ERQC)| Regulation of expression of SLITs and ROBOs| NOTCH3 Activation and Transmission of Signal to the Nucleus| TICAM1-dependent activation of IRF3/IRF7| TICAM1,TRAF6-dependent induction of TAK1 complex| Interleukin-1 signaling| Peroxisomal protein import| Regulation of signaling by CBL| Endosomal Sorting Complex Required For Transport (ESCRT)| Iron uptake and transport| Negative regulators of DDX58/IFIH1 signaling| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon| IRAK1 recruits IKK complex| IKK complex recruitment mediated by RIP1| IRAK2 mediated activation of TAK1 complex| TRAF6-mediated induction of TAK1 complex within TLR4 complex| Negative regulation of NOTCH4 signaling| Chaperone Mediated Autophagy| Late endosomal microautophagy| Alpha-protein kinase 1 signaling pathway| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)| Amyloid fiber formation| Antigen processing: Ubiquitination & Proteasome degradation","S27a-like superfamily|Ribosomal protein S27a|Ubiquitin-like domain","Ubl_ubiquitin_like|Ribosomal protein S27a|Ubiquitin family|Ubiquitin domain profile."]
["NIK-->noncanonical NF-kB signaling","N67_003696","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core|AAA+ ATPase domain|ATPase, AAA-type, conserved site","26Sp45: 26S proteasome subunit P45 family|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA|AAA-protein family signature."]
["NIK-->noncanonical NF-kB signaling","N67_004122","proteasome regulatory particle|proteolysis"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","CSN8/PSMD8/EIF3K|Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit Rpn12","CSN8/PSMD8/EIF3K family|PCI domain profile."]
["NIK-->noncanonical NF-kB signaling","N67_004247","protein binding|proteasome regulatory particle"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S Proteasome non-ATPase regulatory subunit 7/8|JAB1/MPN/MOV34 metalloenzyme domain|MPN domain|Rpn11/EIF3F, C-terminal","MPN_RPN7_8|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN domain profile.|Maintenance of mitochondrial structure and function"]
["NIK-->noncanonical NF-kB signaling","N67_004346","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 4","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_4"]
["NIK-->noncanonical NF-kB signaling","N67_004467","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal","Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|Proteasome subunit|Proteasome subunit A N-terminal signature|proteasome_alpha_type_7"]
["NIK-->noncanonical NF-kB signaling","N67_004468","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit|Proteasome subunit A N-terminal signature|Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|proteasome_alpha_type_4"]
["NIK-->noncanonical NF-kB signaling","N67_004565","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha6|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit","proteasome_alpha_type_6|Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature"]
["NIK-->noncanonical NF-kB signaling","N67_004752","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA+ ATPase domain|ATPase, AAA-type, conserved site|Proteasomal ATPase OB C-terminal domain|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core","26Sp45: 26S proteasome subunit P45 family|AAA-protein family signature.|Proteasomal ATPase OB C-terminal domain|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA"]
["NIK-->noncanonical NF-kB signaling","N67_004822","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit|RPN1/RPN2, N-terminal|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1, C-terminal","RPN1/RPN2 N-terminal domain|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1 C-terminal"]
["NIK-->noncanonical NF-kB signaling","N67_004943","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 1|Nucleophile aminohydrolases, N-terminal","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_1|Proteasome beta-type subunits signature."]
["NIK-->noncanonical NF-kB signaling","N67_004957","protein binding|proteasome regulatory particle assembly"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","PDZ superfamily|Nas2, N-terminal|26S Proteasome non-ATPase regulatory subunit 9","Nas2 N_terminal domain"]
["NIK-->noncanonical NF-kB signaling","N67_004966","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit alpha 3|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome subunit A N-terminal signature|Proteasome subunit"]
["NIK-->noncanonical NF-kB signaling","N67_005012","proteasome activator complex"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator PA28|Proteasome activator PA28, C-terminal domain superfamily|Proteasome activator PA28, C-terminal domain","Proteasome activator pa28 beta subunit"]
["Neutrophil degranulation","N67_000073","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit 3|26S proteasome regulatory subunit, C-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|Proteasome regulatory subunit C-terminal|PCI domain profile."]
["Neutrophil degranulation","N67_000104","ATPase-coupled transmembrane transporter activity"," ROS and RNS production in phagocytes| Neutrophil degranulation| Insulin receptor recycling| Transferrin endocytosis and recycling| Amino acids regulate mTORC1| Ion channel transport","ATPase, V1 complex, subunit D","ATP synthase subunit D|V_ATPase_subD: V-type ATPase, D subunit"]
["Neutrophil degranulation","N67_000108","protein kinase CK2 complex|protein kinase regulator activity"," Synthesis of PC| WNT mediated activation of DVL| Condensation of Prometaphase Chromosomes| Signal transduction by L1| Neutrophil degranulation| Regulation of TP53 Activity through Phosphorylation| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding| Receptor Mediated Mitophagy| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known| Regulation of PTEN stability and activity","Casein kinase II, regulatory subunit|Casein kinase II, regulatory subunit, N-terminal","Casein kinase II regulatory subunit family signature|Casein kinase II regulatory subunit"]
["Neutrophil degranulation","N67_000266","enzyme regulator activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 6|26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1","PCI domain|PCI domain profile.|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|26S proteasome subunit RPN7"]
["Neutrophil degranulation","N67_000449","nucleic acid binding|RNA binding"," Formation of TC-NER Pre-Incision Complex| Transcription-Coupled Nucleotide Excision Repair (TC-NER)| Dual incision in TC-NER| Gap-filling DNA repair synthesis and ligation in TC-NER| Neutrophil degranulation| mRNA Splicing - Major Pathway","RNA recognition motif domain|Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif|Nucleotide-binding alpha-beta plait domain superfamily","RRM_PPIE|RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)|Eukaryotic RNA Recognition Motif (RRM) profile."]
["Neutrophil degranulation","N67_000636","diacylglycerol O-acyltransferase activity|O-acyltransferase activity|triglyceride biosynthetic process"," Acyl chain remodeling of DAG and TAG| Neutrophil degranulation| Triglyceride biosynthesis","Diacylglycerol O-acyltransferase 1|Membrane bound O-acyl transferase, MBOAT|Sterol O-acyltransferase, ACAT/DAG/ARE types","MBOAT, membrane-bound O-acyltransferase family"]
["Neutrophil degranulation","N67_000782","glucose-6-phosphate isomerase activity|gluconeogenesis|glycolytic process"," TP53 Regulates Metabolic Genes| Neutrophil degranulation| Glycolysis| Gluconeogenesis","Phosphoglucose isomerase, C-terminal|Phosphoglucose isomerase, SIS domain 1|Phosphoglucose isomerase, SIS domain 2|Phosphoglucose isomerase (PGI)|Phosphoglucose isomerase, conserved site","SIS_PGI_1|SIS_PGI_2|Glucose-6-phosphate isomerase signature|Glucose-6-phosphate isomerase [pgi].|Phosphoglucose isomerase signature 1.|Phosphoglucose isomerase|Glucose-6-phosphate isomerase family profile.|Phosphoglucose isomerase signature 2."]
["Neutrophil degranulation","N67_000842","proteolysis|cysteine-type peptidase activity"," COPII-mediated vesicle transport| MHC class II antigen presentation| Cargo concentration in the ER| Neutrophil degranulation","Peptidase C1A, papain C-terminal|Cysteine peptidase, histidine active site|Cathepsin C, exclusion domain superfamily|Cathepsin C exclusion|Cysteine peptidase, cysteine active site","Papain family cysteine protease|Eukaryotic thiol (cysteine) proteases histidine active site.|Cathepsin C exclusion domain|Eukaryotic thiol (cysteine) proteases cysteine active site."]
["Neutrophil degranulation","N67_000908",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 13","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain"]
["Neutrophil degranulation","N67_001071","protein kinase CK2 complex|protein kinase regulator activity"," Synthesis of PC| WNT mediated activation of DVL| Condensation of Prometaphase Chromosomes| Signal transduction by L1| Neutrophil degranulation| Regulation of TP53 Activity through Phosphorylation| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding| Receptor Mediated Mitophagy| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known| Regulation of PTEN stability and activity","Casein kinase II, regulatory subunit|Casein kinase II, regulatory subunit, N-terminal","Casein kinase II regulatory subunit|Casein kinase II regulatory subunit family signature"]
["Neutrophil degranulation","N67_001507","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Hypusine synthesis from eIF5A-lysine| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S Proteasome non-ATPase regulatory subunit 1|26S proteasome regulatory subunit RPN2, C-terminal|Proteasome/cyclosome repeat|PBS lyase HEAT-like repeat|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit","26S proteasome regulatory subunit RPN2 C-terminal domain|Proteasome/cyclosome repeat|E-Z type HEAT repeats|HEAT repeats"]
["Neutrophil degranulation","N67_001559","catalytic activity|porphobilinogen synthase activity|tetrapyrrole biosynthetic process|metal ion binding"," Heme biosynthesis| Neutrophil degranulation","Delta-aminolevulinic acid dehydratase|Aldolase-type TIM barrel|Peptidase M16, N-terminal|Delta-aminolevulinic acid dehydratase, active site|Peptidase M16, C-terminal","Delta-aminolevulinic acid dehydratase signature|Delta-aminolevulinic acid dehydratase|Insulinase (Peptidase family M16)|Delta-aminolevulinic acid dehydratase active site.|Peptidase M16 inactive domain"]
["Neutrophil degranulation","N67_001710","protein binding|metallopeptidase activity|Lys63-specific deubiquitinase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Metalloprotease DUBs| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","MPN domain|26S Proteasome non-ATPase regulatory subunit 14|JAB1/MPN/MOV34 metalloenzyme domain|Rpn11/EIF3F, C-terminal","MPN domain profile.|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN_RPN11_CSN5|Maintenance of mitochondrial structure and function"]
["Neutrophil degranulation","N67_001862","signal recognition particle, endoplasmic reticulum targeting|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|endoplasmic reticulum signal peptide binding|signal recognition particle"," SRP-dependent cotranslational protein targeting to membrane| Neutrophil degranulation","Signal recognition particle, SRP14 subunit|Signal recognition particle, SRP9/SRP14 subunit","Signal recognition particle 14kD protein"]
["Neutrophil degranulation","N67_002072","ATP binding|cytosol|chaperonin-containing T-complex|protein folding|unfolded protein binding"," Prefoldin mediated transfer of substrate  to CCT/TriC| Formation of tubulin folding intermediates by CCT/TriC| Folding of actin by CCT/TriC| Association of TriC/CCT with target proteins during biosynthesis| BBSome-mediated cargo-targeting to cilium| Neutrophil degranulation| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding","T-complex protein 1, beta subunit|TCP-1-like chaperonin intermediate domain superfamily|Chaperonin Cpn60/TCP-1 family|GroEL-like apical domain superfamily|Chaperonin TCP-1, conserved site|Chaperone tailless complex polypeptide 1 (TCP-1)|GroEL-like equatorial domain superfamily","TCP1_beta|TCP-1/cpn60 chaperonin family|chap_CCT_beta: T-complex protein 1, beta subunit|Chaperonins TCP-1 signature 1.|Tailless complex polypeptide 1 (chaperone) signature|Chaperonins TCP-1 signature 2."]
["Neutrophil degranulation","N67_002404","catalytic activity|deoxyribose-phosphate aldolase activity|cytoplasm|deoxyribonucleotide catabolic process|lyase activity"," Neutrophil degranulation| Pentose phosphate pathway","Deoxyribose-phosphate aldolase|DeoC/FbaB/LacD aldolase|Aldolase-type TIM barrel","DeoC/LacD family aldolase|deoC: deoxyribose-phosphate aldolase"]
["Neutrophil degranulation","N67_002610","ubiquitin-protein transferase activity"," Neutrophil degranulation| Antigen processing: Ubiquitination & Proteasome degradation","HECT domain|E3 ubiquitin ligase, domain of unknown function DUF908","HECT domain profile.|HECT-domain (ubiquitin-transferase)|HECTc|Domain of Unknown Function (DUF908)"]
["Neutrophil degranulation","N67_002730",null," MHC class II antigen presentation| HSP90 chaperone cycle for steroid hormone receptors (SHR)| Neutrophil degranulation| COPI-mediated anterograde transport| COPI-independent Golgi-to-ER retrograde traffic","Actin family|Actin-related protein 10","Actin"]
["Neutrophil degranulation","N67_002738","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha5|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit A N-terminal signature|Proteasome alpha-type subunits signature.|proteasome_alpha_type_5|Proteasome subunit|Proteasome alpha-type subunit profile."]
["Neutrophil degranulation","N67_002863","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Proteasome subunit alpha2","proteasome_alpha_type_2|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|Proteasome subunit"]
["Neutrophil degranulation","N67_002919",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit RPN5, C-terminal domain|26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4|Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 12|Winged helix-like DNA-binding domain superfamily","26S proteasome regulatory subunit RPN5 C-terminal domain|PCI domain profile.|PCI domain|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15"]
["Neutrophil degranulation","N67_003190","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 7|Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Peptidase T1A, proteasome beta-subunit","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_7|Proteasome beta-type subunit profile.|Proteasome component signature"]
["Neutrophil degranulation","N67_003395","structural molecule activity|cytoplasm|intracellular protein transport|vesicle-mediated transport|membrane coat|COPI vesicle coat"," Neutrophil degranulation| COPI-mediated anterograde transport| COPI-dependent Golgi-to-ER retrograde traffic","Coatomer beta subunit (COPB1)|Clathrin/coatomer adaptor, adaptin-like, N-terminal|Coatomer beta subunit, C-terminal|Coatomer beta subunit, appendage platform domain","Adaptin N terminal region|Coatomer beta C-terminal region|Coatomer beta subunit appendage platform"]
["Neutrophil degranulation","N67_003578",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome regulatory subunit Rpn6, N-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|PCI domain profile.|26S proteasome regulatory subunit RPN6 N-terminal domain"]
["Neutrophil degranulation","N67_003620","catalytic activity|IMP dehydrogenase activity|purine nucleotide biosynthetic process|oxidoreductase activity|oxidation-reduction process"," Neutrophil degranulation| Purine ribonucleoside monophosphate biosynthesis","Aldolase-type TIM barrel|CBS domain|IMP dehydrogenase / GMP reductase, conserved site|IMP dehydrogenase/GMP reductase|Inosine-5'-monophosphate dehydrogenase","CBS domain profile.|IMP dehydrogenase / GMP reductase signature.|IMPDH|CBS_pair_IMPDH|IMP_dehydrog: inosine-5'-monophosphate dehydrogenase|Inosine-5'-monophosphate dehydrogenase [guaB].|IMP dehydrogenase / GMP reductase domain"]
["Neutrophil degranulation","N67_003631","endoplasmic reticulum membrane|protein N-linked glycosylation via asparagine"," SRP-dependent cotranslational protein targeting to membrane| Asparagine N-linked glycosylation| Neutrophil degranulation| Advanced glycosylation endproduct receptor signaling","Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48kDa subunit","Oligosaccharyltransferase 48 kDa subunit beta"]
["Neutrophil degranulation","N67_004003","ATP binding|hydrolase activity"," Translesion Synthesis by POLH| HSF1 activation| ABC-family proteins mediated transport| N-glycan trimming in the ER and Calnexin/Calreticulin cycle| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Defective CFTR causes cystic fibrosis| Josephin domain DUBs| Ovarian tumor domain proteases| Neutrophil degranulation| E3 ubiquitin ligases ubiquitinate target proteins| Protein methylation","CDC48, domain 2|AAA ATPase, CDC48 family|ATPase, AAA-type, core|CDC48, N-terminal subdomain|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, conserved site|AAA+ ATPase domain","AAA|CDC48: AAA family ATPase, CDC48 subfamily|ATPase family associated with various cellular activities (AAA)|Cell division protein 48 (CDC48), N-terminal domain|AAA+ lid domain|Cell division protein 48 (CDC48), domain 2|AAA-protein family signature."]
["Neutrophil degranulation","N67_004193","cytoplasm|autophagy|ubiquitin-like modifier activating enzyme activity"," Macroautophagy| Neutrophil degranulation| Signaling by BRAF and RAF fusions| Antigen processing: Ubiquitination & Proteasome degradation","Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1|Ubiquitin-like modifier-activating enzyme Atg7, N-terminal|THIF-type NAD/FAD binding fold|Ubiquitin-like modifier-activating enzyme Atg7","Ubiquitin-like modifier-activating enzyme ATG7 N-terminus|ThiF family"]
["Neutrophil degranulation","N67_004247","protein binding|proteasome regulatory particle"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S Proteasome non-ATPase regulatory subunit 7/8|JAB1/MPN/MOV34 metalloenzyme domain|MPN domain|Rpn11/EIF3F, C-terminal","MPN_RPN7_8|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN domain profile.|Maintenance of mitochondrial structure and function"]
["Neutrophil degranulation","N67_004407","ATP binding|protein folding|unfolded protein binding"," Prefoldin mediated transfer of substrate  to CCT/TriC| Formation of tubulin folding intermediates by CCT/TriC| Folding of actin by CCT/TriC| Association of TriC/CCT with target proteins during biosynthesis| BBSome-mediated cargo-targeting to cilium| Neutrophil degranulation| Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding","GroEL-like equatorial domain superfamily|T-complex protein 1, theta subunit|Chaperonin Cpn60/TCP-1 family|Chaperone tailless complex polypeptide 1 (TCP-1)|TCP-1-like chaperonin intermediate domain superfamily|GroEL-like apical domain superfamily","TCP1_theta|TCP-1/cpn60 chaperonin family|Tailless complex polypeptide 1 (chaperone) signature|chap_CCT_theta: T-complex protein 1, theta subunit"]
["Neutrophil degranulation","N67_004494","nicotinate phosphoribosyltransferase activity|NAD biosynthetic process"," Nicotinamide salvaging| Neutrophil degranulation","Nicotinate phosphoribosyltransferase family|Nicotinate phosphoribosyltransferase, N-terminal domain|Nicotinate phosphoribosyltransferase C-terminal domain|Nicotinate phosphoribosyltransferase pncB-type","NAPRTase_A|Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain|Nicotinate phosphoribosyltransferase C-terminal domain|NAPRTase_put: nicotinate phosphoribosyltransferase"]
["Neutrophil degranulation","N67_004822","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit|RPN1/RPN2, N-terminal|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1, C-terminal","RPN1/RPN2 N-terminal domain|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1 C-terminal"]
["Neutrophil degranulation","N67_004934","proton transmembrane transporter activity|proton-transporting two-sector ATPase complex, proton-transporting domain|proton-transporting V-type ATPase, V0 domain|proton transmembrane transport"," ROS and RNS production in phagocytes| Neutrophil degranulation| Insulin receptor recycling| Transferrin endocytosis and recycling| Amino acids regulate mTORC1| Ion channel transport","V-ATPase proteolipid subunit C-like domain|V-ATPase proteolipid subunit|V-ATPase proteolipid subunit C, eukaryotic","ATP synthase subunit C|Vacuolar ATP synthase 16kDa subunit signature|V_ATP_synt_C: V-type ATPase, C subunit|ATP-synt_Vo_c_ATP6C_rpt2|ATP-synt_Vo_c_ATP6C_rpt1"]
["Neutrophil degranulation","N67_004943","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 1|Nucleophile aminohydrolases, N-terminal","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_1|Proteasome beta-type subunits signature."]
["Neutrophil degranulation","N67_005127","proteolysis|cysteine-type peptidase activity"," COPII-mediated vesicle transport| MHC class II antigen presentation| Cargo concentration in the ER| Neutrophil degranulation","Cathepsin C exclusion|Cathepsin C, exclusion domain superfamily|Peptidase C1A, papain C-terminal|Cysteine peptidase, histidine active site|Cysteine peptidase, asparagine active site","Cathepsin C exclusion domain|Papain family cysteine protease|Eukaryotic thiol (cysteine) proteases histidine active site.|Eukaryotic thiol (cysteine) proteases asparagine active site."]
["Neutrophil degranulation","N67_005194","proteolysis|cysteine-type peptidase activity"," COPII-mediated vesicle transport| MHC class II antigen presentation| Cargo concentration in the ER| Neutrophil degranulation","Cysteine peptidase, cysteine active site|Peptidase C1A, papain C-terminal|Cathepsin C exclusion|Cysteine peptidase, histidine active site","Eukaryotic thiol (cysteine) proteases cysteine active site.|Papain family cysteine protease|Cathepsin C exclusion domain|Eukaryotic thiol (cysteine) proteases histidine active site."]
["Interleukin-1 signaling","N67_000073","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit 3|26S proteasome regulatory subunit, C-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|Proteasome regulatory subunit C-terminal|PCI domain profile."]
["Interleukin-1 signaling","N67_000266","enzyme regulator activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 6|26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1","PCI domain|PCI domain profile.|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|26S proteasome subunit RPN7"]
["Interleukin-1 signaling","N67_000276","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA+ ATPase domain|ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|ATPase, AAA-type, conserved site|AAA ATPase, AAA+ lid domain|26S proteasome regulatory subunit P45-like","ATPase family associated with various cellular activities (AAA)|AAA|Proteasomal ATPase OB C-terminal domain|AAA-protein family signature.|AAA+ lid domain|26Sp45: 26S proteasome subunit P45 family"]
["Interleukin-1 signaling","N67_000509","peptidase activator activity|lysine-acetylated histone binding|proteasome binding"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator complex subunit 4 C-terminal domain|Proteasome activator complex subunit 4","Domain of unknown function (DUF3437)"]
["Interleukin-1 signaling","N67_000697","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome B-type subunit|Proteasome beta-type subunit, conserved site|Peptidase T1A, proteasome beta-subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|proteasome_beta_type_5|Proteasome beta-type subunit profile.|Proteasome beta-type subunits signature.|Proteasome component signature"]
["Interleukin-1 signaling","N67_000728","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","AAA ATPase, AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA+ ATPase domain|ATPase, AAA-type, conserved site|ATPase, AAA-type, core|26S proteasome regulatory subunit P45-like","AAA+ lid domain|Proteasomal ATPase OB C-terminal domain|AAA|AAA-protein family signature.|ATPase family associated with various cellular activities (AAA)|26Sp45: 26S proteasome subunit P45 family"]
["Interleukin-1 signaling","N67_000908",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 13","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain"]
["Interleukin-1 signaling","N67_001466","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit beta 2|Proteasome beta-type subunit, conserved site|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome beta-type subunits signature.|proteasome_beta_type_2|Proteasome subunit"]
["Interleukin-1 signaling","N67_001507","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Hypusine synthesis from eIF5A-lysine| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S Proteasome non-ATPase regulatory subunit 1|26S proteasome regulatory subunit RPN2, C-terminal|Proteasome/cyclosome repeat|PBS lyase HEAT-like repeat|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit","26S proteasome regulatory subunit RPN2 C-terminal domain|Proteasome/cyclosome repeat|E-Z type HEAT repeats|HEAT repeats"]
["Interleukin-1 signaling","N67_001583","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha 1|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit|Nucleophile aminohydrolases, N-terminal","Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|proteasome_alpha_type_1"]
["Interleukin-1 signaling","N67_001700","ubiquitin-dependent protein catabolic process"," Activation of NF-kappaB in B cells| Prolactin receptor signaling| SCF-beta-TrCP mediated degradation of Emi1| Vpu mediated degradation of CD4| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| NOTCH1 Intracellular Domain Regulates Transcription| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| Circadian Clock| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| NIK-->noncanonical NF-kB signaling| MAP3K8 (TPL2)-dependent MAPK1/3 activation| Orc1 removal from chromatin| Cyclin D associated events in G1| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Regulation of RUNX2 expression and activity| Neddylation| Interleukin-1 signaling| Iron uptake and transport| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","SKP1 component, POZ domain|S-phase kinase-associated protein 1-like|S-phase kinase-associated protein 1|SKP1 component, dimerisation","Skp1 family, tetramerisation domain|BTB_POZ_SKP1|Skp1 family, dimerisation domain"]
["Interleukin-1 signaling","N67_001710","protein binding|metallopeptidase activity|Lys63-specific deubiquitinase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Metalloprotease DUBs| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","MPN domain|26S Proteasome non-ATPase regulatory subunit 14|JAB1/MPN/MOV34 metalloenzyme domain|Rpn11/EIF3F, C-terminal","MPN domain profile.|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN_RPN11_CSN5|Maintenance of mitochondrial structure and function"]
["Interleukin-1 signaling","N67_001726","threonine-type endopeptidase activity|proteasome core complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome subunit beta Pre3|Nucleophile aminohydrolases, N-terminal","Proteasome subunit"]
["Interleukin-1 signaling","N67_001963","threonine-type endopeptidase activity|proteasome core complex|proteolysis|HslUV protease complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATP-dependent protease, HslV subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome B-type subunit","ATP_dep_HslV: ATP-dependent protease HslVU, peptidase subunit|Proteasome subunit|Proteasome beta-type subunit profile.|protease_HslV"]
["Interleukin-1 signaling","N67_002329","ATP binding|cytoplasm|hydrolase activity|protein catabolic process|proteasome-activating ATPase activity"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","ATPase, AAA-type, core|Proteasomal ATPase OB C-terminal domain|26S proteasome regulatory subunit P45-like|ATPase, AAA-type, conserved site|AAA+ ATPase domain|AAA ATPase, AAA+ lid domain|26S Proteasome regulatory subunit 6B","ATPase family associated with various cellular activities (AAA)|Proteasomal ATPase OB C-terminal domain|26Sp45: 26S proteasome subunit P45 family|AAA|AAA-protein family signature.|AAA+ lid domain"]
["Interleukin-1 signaling","N67_002487","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteasome core complex, beta-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta 3 subunit|Proteasome beta-type subunit, conserved site","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_3|Proteasome beta-type subunits signature."]
["Interleukin-1 signaling","N67_002738","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha5|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit A N-terminal signature|Proteasome alpha-type subunits signature.|proteasome_alpha_type_5|Proteasome subunit|Proteasome alpha-type subunit profile."]
["Interleukin-1 signaling","N67_002863","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Proteasome subunit alpha2","proteasome_alpha_type_2|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature|Proteasome subunit"]
["Interleukin-1 signaling","N67_002919",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit RPN5, C-terminal domain|26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4|Proteasome component (PCI) domain|26S Proteasome non-ATPase regulatory subunit 12|Winged helix-like DNA-binding domain superfamily","26S proteasome regulatory subunit RPN5 C-terminal domain|PCI domain profile.|PCI domain|motif in proteasome subunits, Int-6, Nip-1 and TRIP-15"]
["Interleukin-1 signaling","N67_003190","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 7|Proteasome B-type subunit|Nucleophile aminohydrolases, N-terminal|Peptidase T1A, proteasome beta-subunit","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_7|Proteasome beta-type subunit profile.|Proteasome component signature"]
["Interleukin-1 signaling","N67_003578",null," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome component (PCI) domain|26S proteasome regulatory subunit Rpn6, N-terminal","motif in proteasome subunits, Int-6, Nip-1 and TRIP-15|PCI domain|PCI domain profile.|26S proteasome regulatory subunit RPN6 N-terminal domain"]
["Interleukin-1 signaling","N67_003579","structural constituent of ribosome|protein binding|ribosome|translation"," Translesion synthesis by REV1| Recognition of DNA damage by PCNA-containing replication complex| Translesion Synthesis by POLH| Activation of NF-kappaB in B cells| ISG15 antiviral mechanism| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants| ER-Phagosome pathway| Downregulation of ERBB4 signaling| Spry regulation of FGF signaling| Downregulation of ERBB2:ERBB3 signaling| L13a-mediated translational silencing of Ceruloplasmin expression| Peptide chain elongation| Budding and maturation of HIV virion| NOD1/2 Signaling Pathway| TICAM1, RIP1-mediated IKK complex recruitment| DDX58/IFIH1-mediated induction of interferon-alpha/beta| APC/C:Cdc20 mediated degradation of Cyclin B| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Membrane binding and targetting of GAG proteins| Assembly Of The HIV Virion| APC-Cdc20 mediated degradation of Nek2A| SRP-dependent cotranslational protein targeting to membrane| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| EGFR downregulation| SCF(Skp2)-mediated degradation of p27/p21| Viral mRNA Translation| Degradation of beta-catenin by the destruction complex| TCF dependent signaling in response to WNT| Downstream TCR signaling| NRIF signals cell death from the nucleus| p75NTR recruits signalling complexes| NF-kB is activated and signals survival| Regulation of activated PAK-2p34 by proteasome mediated degradation| NOTCH1 Intracellular Domain Regulates Transcription| Activated NOTCH1 Transmits Signal to the Nucleus| Downregulation of TGF-beta receptor signaling| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)| Downregulation of SMAD2/3:SMAD4 transcriptional activity| SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription| Selenocysteine synthesis| Separation of Sister Chromatids| Oxidative Stress Induced Senescence| Senescence-Associated Secretory Phenotype (SASP)| Oncogene Induced Senescence| Regulation of PLK1 Activity at G2/M Transition| Constitutive Signaling by NOTCH1 PEST Domain Mutants| Stimuli-sensing channels| Constitutive Signaling by NOTCH1 HD Domain Mutants| FCERI mediated NF-kB activation| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants| NOTCH2 Activation and Transmission of Signal to the Nucleus| Regulation of innate immune responses to cytosolic DNA| Glycogen synthesis| Autodegradation of the E3 ubiquitin ligase COP1| Deactivation of the beta-catenin transactivating complex| Myoclonic epilepsy of Lafora| ABC-family proteins mediated transport| Circadian Clock| TAK1 activates NFkB by phosphorylation and activation of IKKs complex| activated TAK1 mediates p38 MAPK activation| JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Regulation of FZD by ubiquitination| PINK1-PRKN Mediated Mitophagy| N-glycan trimming in the ER and Calnexin/Calreticulin cycle| Regulation of TNFR1 signaling| TNFR1-induced NFkappaB signaling pathway| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Negative regulation of FGFR1 signaling| Negative regulation of FGFR2 signaling| Negative regulation of FGFR3 signaling| Negative regulation of FGFR4 signaling| Translesion synthesis by POLK| Translesion synthesis by POLI| Termination of translesion DNA synthesis| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| Negative regulation of MAPK pathway| Regulation of necroptotic cell death| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAP3K8 (TPL2)-dependent MAPK1/3 activation| HDR through Homologous Recombination (HRR)| MAPK6/MAPK4 signaling| UCH proteinases| Josephin domain DUBs| Ub-specific processing proteases| Ovarian tumor domain proteases| Metalloprotease DUBs| Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks| Processing of DNA double-strand break ends| DNA Damage Recognition in GG-NER| Formation of Incision Complex in GG-NER| Gap-filling DNA repair synthesis and ligation in GG-NER| Dual Incision in GG-NER| Formation of TC-NER Pre-Incision Complex| Transcription-Coupled Nucleotide Excision Repair (TC-NER)| Dual incision in TC-NER| Gap-filling DNA repair synthesis and ligation in TC-NER| Fanconi Anemia Pathway| Major pathway of rRNA processing in the nucleolus and cytosol| Regulation of TP53 Activity through Phosphorylation| Regulation of TP53 Degradation| Regulation of TP53 Activity through Methylation| Negative regulation of MET activity| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| Cyclin D associated events in G1| G2/M Checkpoints| Stabilization of p53| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Translation initiation complex formation| Formation of a pool of free 40S subunits| Formation of the ternary complex, and subsequently, the 43S complex| Ribosomal scanning and start codon recognition| GTP hydrolysis and joining of the 60S ribosomal subunit| Eukaryotic Translation Termination| Ubiquitin-dependent degradation of Cyclin D| PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| Cargo recognition for clathrin-mediated endocytosis| Clathrin-mediated endocytosis| Downregulation of ERBB2 signaling| Synthesis of active ubiquitin: roles of E1 and E2 enzymes| E3 ubiquitin ligases ubiquitinate target proteins| InlB-mediated entry of Listeria monocytogenes into host cell| InlA-mediated entry of Listeria monocytogenes into host cells| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN localization| Regulation of PTEN stability and activity| Neddylation| ER Quality Control Compartment (ERQC)| Regulation of expression of SLITs and ROBOs| NOTCH3 Activation and Transmission of Signal to the Nucleus| TICAM1-dependent activation of IRF3/IRF7| TICAM1,TRAF6-dependent induction of TAK1 complex| Interleukin-1 signaling| Peroxisomal protein import| Regulation of signaling by CBL| Endosomal Sorting Complex Required For Transport (ESCRT)| Iron uptake and transport| Negative regulators of DDX58/IFIH1 signaling| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon| IRAK1 recruits IKK complex| IKK complex recruitment mediated by RIP1| IRAK2 mediated activation of TAK1 complex| TRAF6-mediated induction of TAK1 complex within TLR4 complex| Negative regulation of NOTCH4 signaling| Chaperone Mediated Autophagy| Late endosomal microautophagy| Alpha-protein kinase 1 signaling pathway| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation| Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)| Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)| Amyloid fiber formation| Antigen processing: Ubiquitination & Proteasome degradation","S27a-like superfamily|Ribosomal protein S27a|Ubiquitin-like domain","Ubl_ubiquitin_like|Ribosomal protein S27a|Ubiquitin family|Ubiquitin domain profile."]
["Interleukin-1 signaling","N67_003696","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core|AAA+ ATPase domain|ATPase, AAA-type, conserved site","26Sp45: 26S proteasome subunit P45 family|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA|AAA-protein family signature."]
["Interleukin-1 signaling","N67_004122","proteasome regulatory particle|proteolysis"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","CSN8/PSMD8/EIF3K|Proteasome component (PCI) domain|26S proteasome non-ATPase regulatory subunit Rpn12","CSN8/PSMD8/EIF3K family|PCI domain profile."]
["Interleukin-1 signaling","N67_004247","protein binding|proteasome regulatory particle"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S Proteasome non-ATPase regulatory subunit 7/8|JAB1/MPN/MOV34 metalloenzyme domain|MPN domain|Rpn11/EIF3F, C-terminal","MPN_RPN7_8|JAB1/Mov34/MPN/PAD-1 ubiquitin protease|MPN domain profile.|Maintenance of mitochondrial structure and function"]
["Interleukin-1 signaling","N67_004346","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 4","Proteasome subunit|Proteasome beta-type subunits signature.|proteasome_beta_type_4"]
["Interleukin-1 signaling","N67_004467","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome alpha-type subunit|Proteasome alpha-subunit, N-terminal domain|Proteasome, subunit alpha/beta|Nucleophile aminohydrolases, N-terminal","Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|Proteasome subunit|Proteasome subunit A N-terminal signature|proteasome_alpha_type_7"]
["Interleukin-1 signaling","N67_004468","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome, subunit alpha/beta|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome alpha-type subunit","Proteasome subunit|Proteasome subunit A N-terminal signature|Proteasome alpha-type subunit profile.|Proteasome alpha-type subunits signature.|proteasome_alpha_type_4"]
["Interleukin-1 signaling","N67_004565","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Nucleophile aminohydrolases, N-terminal|Proteasome alpha-subunit, N-terminal domain|Proteasome subunit alpha6|Proteasome, subunit alpha/beta|Proteasome alpha-type subunit","proteasome_alpha_type_6|Proteasome subunit|Proteasome alpha-type subunit profile.|Proteasome subunit A N-terminal signature"]
["Interleukin-1 signaling","N67_004752","ATP binding|cytoplasm|hydrolase activity|protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","26S proteasome regulatory subunit P45-like|AAA+ ATPase domain|ATPase, AAA-type, conserved site|Proteasomal ATPase OB C-terminal domain|AAA ATPase, AAA+ lid domain|ATPase, AAA-type, core","26Sp45: 26S proteasome subunit P45 family|AAA-protein family signature.|Proteasomal ATPase OB C-terminal domain|AAA+ lid domain|ATPase family associated with various cellular activities (AAA)|AAA"]
["Interleukin-1 signaling","N67_004822","proteasome complex|enzyme regulator activity|regulation of protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Armadillo-like helical|26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit|RPN1/RPN2, N-terminal|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1, C-terminal","RPN1/RPN2 N-terminal domain|Proteasome/cyclosome repeat|26S proteasome non-ATPase regulatory subunit RPN1 C-terminal"]
["Interleukin-1 signaling","N67_004943","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| Neutrophil degranulation| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome B-type subunit|Proteasome, subunit alpha/beta|Proteasome beta-type subunit, conserved site|Proteasome subunit beta 1|Nucleophile aminohydrolases, N-terminal","Proteasome beta-type subunit profile.|Proteasome subunit|proteasome_beta_type_1|Proteasome beta-type subunits signature."]
["Interleukin-1 signaling","N67_004957","protein binding|proteasome regulatory particle assembly"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","PDZ superfamily|Nas2, N-terminal|26S Proteasome non-ATPase regulatory subunit 9","Nas2 N_terminal domain"]
["Interleukin-1 signaling","N67_004966","endopeptidase activity|threonine-type endopeptidase activity|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|proteolysis involved in cellular protein catabolic process"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome subunit alpha 3|Proteasome alpha-subunit, N-terminal domain|Nucleophile aminohydrolases, N-terminal|Proteasome, subunit alpha/beta","Proteasome subunit A N-terminal signature|Proteasome subunit"]
["Interleukin-1 signaling","N67_005012","proteasome activator complex"," Activation of NF-kappaB in B cells| Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha| ER-Phagosome pathway| Cross-presentation of soluble exogenous antigens (endosomes)| Autodegradation of Cdh1 by Cdh1:APC/C| SCF-beta-TrCP mediated degradation of Emi1| APC/C:Cdc20 mediated degradation of Securin| APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1| Cdc20:Phospho-APC/C mediated degradation of Cyclin A| Vpu mediated degradation of CD4| Vif-mediated degradation of APOBEC3G| SCF(Skp2)-mediated degradation of p27/p21| Degradation of beta-catenin by the destruction complex| Downstream TCR signaling| Regulation of activated PAK-2p34 by proteasome mediated degradation| Separation of Sister Chromatids| FCERI mediated NF-kB activation| Autodegradation of the E3 ubiquitin ligase COP1| Regulation of ornithine decarboxylase (ODC)| ABC-family proteins mediated transport| AUF1 (hnRNP D0) binds and destabilizes mRNA| Asymmetric localization of PCP proteins| Degradation of AXIN| Degradation of DVL| Hedgehog ligand biogenesis| Hh mutants that don't undergo autocatalytic processing are degraded by ERAD| Dectin-1 mediated noncanonical NF-kB signaling| CLEC7A (Dectin-1) signaling| Degradation of GLI1 by the proteasome| Degradation of GLI2 by the proteasome| GLI3 is processed to GLI3R by the proteasome| Hedgehog 'on' state| Regulation of RAS by GAPs| TNFR2 non-canonical NF-kB pathway| NIK-->noncanonical NF-kB signaling| Defective CFTR causes cystic fibrosis| MAPK6/MAPK4 signaling| UCH proteinases| Ub-specific processing proteases| CDT1 association with the CDC6:ORC:origin complex| Orc1 removal from chromatin| CDK-mediated phosphorylation and removal of Cdc6| G2/M Checkpoints| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A| Ubiquitin-dependent degradation of Cyclin D| The role of GTSE1 in G2/M progression after G2 checkpoint| FBXL7 down-regulates AURKA during mitotic entry and in early mitosis| RUNX1 regulates transcription of genes involved in differentiation of HSCs| Regulation of RUNX2 expression and activity| Regulation of RUNX3 expression and activity| Regulation of PTEN stability and activity| Neddylation| Regulation of expression of SLITs and ROBOs| Interleukin-1 signaling| Negative regulation of NOTCH4 signaling| Antigen processing: Ubiquitination & Proteasome degradation","Proteasome activator PA28|Proteasome activator PA28, C-terminal domain superfamily|Proteasome activator PA28, C-terminal domain","Proteasome activator pa28 beta subunit"]