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{"sheet":"Sheet1","index":0,"n_rows":26,"n_cols":2,"rows_kept":26,"merged":[[1,0,1,1]],"flags":["formulas_cached_only"]}
["Supply Table 1"]
["Primer sequence"]
["Gene","Primer sequence"]
["ELK3","F: GGACACATCAAAGCAAACACCA"]
[null,"R:TCAGCGGAGCAACTGGACTAA"]
[]
["AFF4","F: CAATAGGACTCCTGTTAAACCCTC"]
[null,"R: CATTCTTATGCTTCCTCTTGCC"]
[]
["RCOR2","F: CACTCGCACGACAGCATGAT"]
[null,"R: AGCGCCTGCTCAATGTTGTA"]
[]
["PHACTR2","F: AGTCTGAAGAAGGTAATGGCTCTG"]
[null,"R: TTTGGGTTTAGGTTTGGGTCTA"]
[]
["CIZ1","F: TGGCCTAGATGTGGGAGAATGT"]
[null,"R: CTGCTTAGAGGGAGTGCTGGTA"]
[]
["NUAK1","F: TGGCCGAGTGGTTGCTATAAA"]
[null,"R: TGATGTAATCGTACAGCTCCCC"]
[]
["MCC","F: AACCAGTTGGGAGCAGATGAAA"]
[null,"R: CACCCAAACTGTTGTCACTGCT"]
[]
["β-ACTIN","F: CACCCAGCACAATGAAGATCAAGAT"]
[null,"R: CCAGTTTTTAAATCCTGAGTCAAGC"]

{"sheet":"Sheet2","index":1,"n_rows":27,"n_cols":3,"rows_kept":27,"merged":[[1,0,1,2]],"flags":["formulas_cached_only"]}
["Supply Table 2"]
["The mutation of m6A regulators"]
["Gene symbol","Type","Number"]
["YTHDF1","Missense_Mutation; Frame_Shift_Ins",7]
["IGF2BP1","Missense_Mutation; In_Frame_Ins",6]
["IGF2BP3","Missense_Mutation; Frame_Shift_Del; Frame_Shift_Ins",5]
["ZC3H13","Missense_Mutation",5]
["FTO","Missense_Mutation; Frame_Shift_Del",4]
["ELAVL1","Missense_Mutation",4]
["CBLL1","Missense_Mutation; Nonsense_Mutation",3]
["RBM15B","Missense_Mutation",3]
["YTHDC1","Missense_Mutation; Nonsense_Mutation",3]
["METTL3","Missense_Mutation; Frame_Shift_Del",3]
["EIF3A","Missense_Mutation; Frame_Shift_Ins",2]
["YTHDC2","Nonsense_Mutation; Splice_Site",2]
["YTHDF3","Missense_Mutation",2]
["RBMX","Missense_Mutation",2]
["METTL16","Nonsense_Mutation; Frame_Shift_Ins",2]
["LRPPRC","Missense_Mutation",2]
["IGF2BP2","In_Frame_Ins",1]
["RBM15","Missense_Mutation",1]
["YTHDF2","Missense_Mutation",1]
["METTL14","Missense_Mutation;",1]
["WTAP","Splice_Site",1]
["HNRNPC","NA",0]
["HNRNPA2B1","NA",0]
["ALBH5","NA",0]

{"sheet":"Sheet3","index":2,"n_rows":12,"n_cols":6,"rows_kept":12,"merged":[[0,0,0,1],[1,0,1,5]],"flags":["formulas_cached_only"]}
["Supply Table 3"]
["Patterns of CNV Occurrence in 372 Ovarian Cancer Patients."]
["m6A","Shallow deletion","Dilpoid","Copy numeber gain","CNV sum","Percentage"]
["CBLL1",17,297,58,75,{"v":0.2016,"d":"20.16%"}]
["FTO",20,315,37,57,{"v":0.1532,"d":"15.32%"}]
["HNRNPC",23,253,96,119,{"v":0.3199,"d":"31.99%"}]
["METTL3",21,260,91,112,{"v":0.3011,"d":"30.11%"}]
["METTL14",48,301,23,71,{"v":0.1909,"d":"19.09%"}]
["RBM15B",51,313,8,59,{"v":0.1586,"d":"15.86%"}]
["WTAP",109,246,17,126,{"v":0.3387,"d":"33.87%"}]
["YTHDC2",68,276,28,96,{"v":0.2581,"d":"25.81%"}]
["ZC3H13",59,299,14,73,{"v":0.1962,"d":"19.62%"}]

{"sheet":"Sheet4","index":3,"n_rows":85,"n_cols":6,"rows_kept":85,"merged":[[1,0,1,5]],"flags":["formulas_cached_only"]}
["Supply Table 4"]
["Function annotation for m6A phenotype-related gens"]
["ONTOLOGY","ID","Description","qvalue","GeneRatio","geneID"]
["BP","GO:0030198","extracellular matrix organization",{"v":9.69933841529858e-08,"d":"9.70E-08"},"28/323","APBB2/LAMB1/CLASP1/LAMC1/ADAMTS4/CREB3L1/BGN/MMP2/ITGA5/KDR/SH3PXD2B/CRISPLD2/PDPN/NID2/LOXL3/COL5A1/ECM2/FBLN2/SPARC/COL6A3/PDGFRA/HSPG2/LOXL1/THBS1/SOX9/MFAP4/COL5A2/MMP19"]
["BP","GO:0043062","extracellular structure organization",{"v":9.69933841529858e-08,"d":"9.70E-08"},"28/323","APBB2/LAMB1/CLASP1/LAMC1/ADAMTS4/CREB3L1/BGN/MMP2/ITGA5/KDR/SH3PXD2B/CRISPLD2/PDPN/NID2/LOXL3/COL5A1/ECM2/FBLN2/SPARC/COL6A3/PDGFRA/HSPG2/LOXL1/THBS1/SOX9/MFAP4/COL5A2/MMP19"]
["BP","GO:0022604","regulation of cell morphogenesis",0.000337788952344916,"26/323","WDR36/MYH10/SH3D19/MPL/SYNGAP1/CDK5R1/DLG4/PAFAH1B1/PREX1/KDR/GRIP1/PDPN/DNMBP/SEMA6A/SYT1/NEDD9/FGD6/SPARC/NFATC4/KIT/SEMA3C/WASF3/FZD4/TUBB2B/CDH2/CUX2"]
["BP","GO:0048736","appendage development",0.000337788952344916,"15/323","MED1/RPGRIP1L/ROR2/PAM/GLI3/IFT140/NR2F2/FRAS1/TULP3/SALL1/SEMA3C/IQCE/PTCH1/CYP26B1/SOX9"]
["BP","GO:0060173","limb development",0.000337788952344916,"15/323","MED1/RPGRIP1L/ROR2/PAM/GLI3/IFT140/NR2F2/FRAS1/TULP3/SALL1/SEMA3C/IQCE/PTCH1/CYP26B1/SOX9"]
["BP","GO:0031589","cell-substrate adhesion",0.000537396160766321,"21/323","LAMB1/MAP4K4/FER/CLASP1/LAMC1/PREX1/SPOCK1/ITGA5/KDR/PDPN/NID2/ECM2/FBLN2/NEDD9/CDK6/HSPG2/FZD4/ADAMTS12/THBS1/MMRN1/CORO2B"]
["BP","GO:0035107","appendage morphogenesis",0.00071471247589771,"13/323","MED1/RPGRIP1L/ROR2/GLI3/IFT140/FRAS1/TULP3/SALL1/SEMA3C/IQCE/PTCH1/CYP26B1/SOX9"]
["BP","GO:0035108","limb morphogenesis",0.00071471247589771,"13/323","MED1/RPGRIP1L/ROR2/GLI3/IFT140/FRAS1/TULP3/SALL1/SEMA3C/IQCE/PTCH1/CYP26B1/SOX9"]
["BP","GO:0010810","regulation of cell-substrate adhesion",0.00185861334396035,"15/323","MAP4K4/CLASP1/PREX1/SPOCK1/ITGA5/KDR/PDPN/ECM2/FBLN2/NEDD9/CDK6/FZD4/THBS1/MMRN1/CORO2B"]
["BP","GO:0001738","morphogenesis of a polarized epithelium",0.00197965300141603,"12/323","RPGRIP1L/AP2B1/FZD1/ROR2/PRICKLE2/NKD1/DACT1/PAFAH1B1/EXOC5/OPHN1/GPC6/FZD4"]
["BP","GO:0050808","synapse organization",0.00249457188992576,"21/323","FZD1/MYH10/PCDHGC3/SYNGAP1/CDK5R1/NLGN2/DLG4/PAFAH1B1/NLGN4X/WASF1/LRRN1/OPHN1/ZC4H2/SDK1/SPARC/NFATC4/THBS2/WASF3/MDGA1/CDH2/CUX2"]
["BP","GO:0001736","establishment of planar polarity",0.00249457188992576,"11/323","RPGRIP1L/AP2B1/FZD1/ROR2/PRICKLE2/NKD1/DACT1/PAFAH1B1/EXOC5/GPC6/FZD4"]
["BP","GO:0007164","establishment of tissue polarity",0.00249457188992576,"11/323","RPGRIP1L/AP2B1/FZD1/ROR2/PRICKLE2/NKD1/DACT1/PAFAH1B1/EXOC5/GPC6/FZD4"]
["BP","GO:0035924","cellular response to vascular endothelial growth factor stimulus",0.00490180047732615,"8/323","MAPKAPK2/DLL1/KDR/SEMA6A/PDGFRA/ADAMTS12/NR4A1/EGR3"]
["BP","GO:0060348","bone development",0.00552251986525669,"14/323","MED1/PAFAH1B1/SH3PXD2B/PTPN11/GLI3/PLS3/XYLT1/SPARC/COL6A3/KIT/CHAD/TULP3/CYP26B1/SOX9"]
["BP","GO:0010975","regulation of neuron projection development",0.0104327255665704,"22/323","KIDINS220/ABL2/FZD1/WDR36/MAP4K4/SYNGAP1/CDK5R1/DLG4/PAFAH1B1/PREX1/SPOCK1/GRIP1/SEMA6A/SYT1/CRTC1/SDK1/NFATC4/SEMA3C/FZD4/TUBB2B/CDH2/CUX2"]
["BP","GO:0030326","embryonic limb morphogenesis",0.0104327255665704,"10/323","MED1/RPGRIP1L/ROR2/GLI3/IFT140/FRAS1/TULP3/SALL1/PTCH1/CYP26B1"]
["BP","GO:0035113","embryonic appendage morphogenesis",0.0104327255665704,"10/323","MED1/RPGRIP1L/ROR2/GLI3/IFT140/FRAS1/TULP3/SALL1/PTCH1/CYP26B1"]
["BP","GO:0001654","eye development",0.0104327255665704,"18/323","MED1/RPGRIP1L/MYH10/DLL1/NKD1/SH3PXD2B/GLI3/IFT140/COL5A1/XRN2/SDK1/SHROOM2/TULP3/PDGFRA/RDH13/FZD4/SOX9/COL5A2"]
["BP","GO:0018108","peptidyl-tyrosine phosphorylation",0.0104327255665704,"18/323","ABL2/EPHB4/ROR2/FER/DLG4/ITGA5/KDR/PTPN11/NEK1/TIE1/NEDD9/PDGFD/GHR/KIT/PDGFRA/AFAP1L2/ERRFI1/ADRA2A"]
["BP","GO:0018212","peptidyl-tyrosine modification",0.0105345306813101,"18/323","ABL2/EPHB4/ROR2/FER/DLG4/ITGA5/KDR/PTPN11/NEK1/TIE1/NEDD9/PDGFD/GHR/KIT/PDGFRA/AFAP1L2/ERRFI1/ADRA2A"]
["BP","GO:0150063","visual system development",0.0105345306813101,"18/323","MED1/RPGRIP1L/MYH10/DLL1/NKD1/SH3PXD2B/GLI3/IFT140/COL5A1/XRN2/SDK1/SHROOM2/TULP3/PDGFRA/RDH13/FZD4/SOX9/COL5A2"]
["BP","GO:0048880","sensory system development",0.0119704727185364,"18/323","MED1/RPGRIP1L/MYH10/DLL1/NKD1/SH3PXD2B/GLI3/IFT140/COL5A1/XRN2/SDK1/SHROOM2/TULP3/PDGFRA/RDH13/FZD4/SOX9/COL5A2"]
["BP","GO:0034329","cell junction assembly",0.0130082991973003,"19/323","FZD1/MAP4K4/CLASP1/LAMC1/NLGN2/ITGA5/KDR/NLGN4X/LRRN1/OPHN1/FLNC/SDK1/CDH5/THBS2/MDGA1/THBS1/CDH2/CUX2/CORO2B"]
["BP","GO:0045665","negative regulation of neuron differentiation",0.019531481292164,"13/323","MED1/MAP4K4/DLL1/SYNGAP1/CDK5R1/PAFAH1B1/SPOCK1/GLI3/SEMA6A/NFATC4/SEMA3C/ID3/SOX9"]
["BP","GO:0043406","positive regulation of MAP kinase activity",0.0204437110420585,"14/323","KIDINS220/SASH1/TAOK1/MAPKAPK2/ROR2/PTPN11/PDGFD/GHR/KIT/MAP3K14/SAMD5/FZD4/THBS1/ADRA2A"]
["BP","GO:0072001","renal system development",0.0219979374568083,"15/323","RPGRIP1L/DLL1/GLI3/IFT140/PODXL/PDGFD/PTCD2/FRAS1/GPR4/SALL1/PDGFRA/PTCH1/ID3/CYP26B1/SOX9"]
["BP","GO:0071902","positive regulation of protein serine/threonine kinase activity",0.0275801637529144,"16/323","KIDINS220/SASH1/TAOK1/MAPKAPK2/ROR2/CDK5R1/PTPN11/CCND2/PDGFD/GHR/KIT/MAP3K14/SAMD5/FZD4/THBS1/ADRA2A"]
["BP","GO:0010811","positive regulation of cell-substrate adhesion",0.0275801637529144,"9/323","MAP4K4/PREX1/ITGA5/KDR/ECM2/FBLN2/NEDD9/CDK6/MMRN1"]
["BP","GO:0060041","retina development in camera-type eye",0.0277297075035697,"10/323","MED1/MYH10/DLL1/IFT140/XRN2/SDK1/PDGFRA/RDH13/FZD4/SOX9"]
["BP","GO:0043405","regulation of MAP kinase activity",0.0277297075035697,"16/323","KIDINS220/SASH1/TAOK1/MAPKAPK2/ROR2/SPRED2/PTPN11/KSR1/PDGFD/GHR/KIT/MAP3K14/SAMD5/FZD4/THBS1/ADRA2A"]
["BP","GO:0071229","cellular response to acid chemical",0.0287494874717161,"12/323","ABL2/MMP2/KDR/SESN1/PDGFD/NFATC4/PDGFRA/FZD4/ID3/CYP26B1/SOX9/COL5A2"]
["BP","GO:1905330","regulation of morphogenesis of an epithelium",0.0291262939285166,"11/323","AP2B1/FZD1/ROR2/CLASP1/PRICKLE2/NKD1/DACT1/GPC6/FZD4/ADAMTS12/SOX9"]
["BP","GO:0034446","substrate adhesion-dependent cell spreading",0.0315115586367774,"8/323","LAMB1/FER/LAMC1/PREX1/PDPN/NEDD9/HSPG2/FZD4"]
["BP","GO:0001822","kidney development",0.0325779177185844,"14/323","RPGRIP1L/DLL1/GLI3/PODXL/PDGFD/PTCD2/FRAS1/GPR4/SALL1/PDGFRA/PTCH1/ID3/CYP26B1/SOX9"]
["BP","GO:0021549","cerebellum development",0.0340432694197407,"8/323","RPGRIP1L/MYH10/DLL1/CDK5R1/NLGN4X/PTPN11/OPHN1/FZD4"]
["BP","GO:0001667","ameboidal-type cell migration",0.0374207644224237,"19/323","SASH1/EPHB4/MAP4K4/FER/CLASP1/MCC/PAFAH1B1/KDR/PTPN11/NR2F2/IQSEC1/SEMA6A/SPARC/KIT/SEMA3C/NR4A1/THBS1/SOX9/EGR3"]
["BP","GO:0003158","endothelium development",0.0374207644224237,"9/323","KDM6B/DLL1/KDR/PDPN/NR2F2/PDE4D/CDH5/ADAMTS12/APOLD1"]
["BP","GO:0021801","cerebral cortex radial glia guided migration",0.0374207644224237,"4/323","LAMB1/CDK5R1/PAFAH1B1/GLI3"]
["BP","GO:0022030","telencephalon glial cell migration",0.0374207644224237,"4/323","LAMB1/CDK5R1/PAFAH1B1/GLI3"]
["BP","GO:0021766","hippocampus development",0.0374207644224237,"7/323","KDM6B/CDK5R1/PAFAH1B1/GLI3/PHLPP2/XRN2/CDK6"]
["BP","GO:0022617","extracellular matrix disassembly",0.0374207644224237,"7/323","CLASP1/LAMC1/ADAMTS4/MMP2/SH3PXD2B/PDPN/MMP19"]
["BP","GO:1901136","carbohydrate derivative catabolic process",0.0386334006710669,"11/323","BGN/GPC6/PGM2/PDE4D/NEU3/NT5E/NAGA/HSPG2/NUDT4/ADAMTS12/GLA"]
["BP","GO:0099173","postsynapse organization",0.0388700622189829,"10/323","MYH10/SYNGAP1/CDK5R1/NLGN2/DLG4/PAFAH1B1/NLGN4X/OPHN1/CDH2/CUX2"]
["BP","GO:0150011","regulation of neuron projection arborization",0.0388700622189829,"3/323","DLG4/GRIP1/FZD4"]
["BP","GO:0060071","Wnt signaling pathway, planar cell polarity pathway",0.0391178766019557,"8/323","AP2B1/FZD1/ROR2/PRICKLE2/NKD1/DACT1/GPC6/FZD4"]
["BP","GO:0021532","neural tube patterning",0.0392359449533281,"5/323","RPGRIP1L/GLI3/IFT140/TULP3/PTCH1"]
["BP","GO:0001503","ossification",0.0392359449533281,"17/323","FZD1/ROR2/CREB3L1/DNAJC13/MN1/MMP2/KLF10/SH3PXD2B/GLI3/NBR1/XYLT1/SPARC/CDK6/PTCH1/ID3/SOX9/COL5A2"]
["BP","GO:0050803","regulation of synapse structure or activity",0.0394367590772772,"12/323","FZD1/SYNGAP1/CDK5R1/NLGN2/PAFAH1B1/LRRN1/SPARC/NFATC4/THBS2/MDGA1/CDH2/CUX2"]
["BP","GO:0090175","regulation of establishment of planar polarity",0.0406589275070122,"8/323","AP2B1/FZD1/ROR2/PRICKLE2/NKD1/DACT1/GPC6/FZD4"]
["BP","GO:0001655","urogenital system development",0.0407272788816551,"15/323","RPGRIP1L/DLL1/GLI3/IFT140/PODXL/PDGFD/PTCD2/FRAS1/GPR4/SALL1/PDGFRA/PTCH1/ID3/CYP26B1/SOX9"]
["BP","GO:0060541","respiratory system development",0.0407272788816551,"11/323","RPGRIP1L/CRISPLD2/GLI3/PDPN/LOXL3/SPARC/TULP3/PDGFRA/SOX9/ERRFI1/MSC"]
["BP","GO:0022037","metencephalon development",0.0407272788816551,"8/323","RPGRIP1L/MYH10/DLL1/CDK5R1/NLGN4X/PTPN11/OPHN1/FZD4"]
["BP","GO:0031109","microtubule polymerization or depolymerization",0.0424134022379903,"8/323","TAOK1/CLASP1/CDK5R1/CEP192/KIF2A/CDH5/MAP1A/NAV3"]
["BP","GO:0021670","lateral ventricle development",0.0431698832243576,"3/323","RPGRIP1L/MYH10/CDK6"]
["BP","GO:0016358","dendrite development",0.0433955731054683,"12/323","KIDINS220/SYNGAP1/CDK5R1/DLG4/PAFAH1B1/PREX1/GRIP1/CRTC1/SDK1/NFATC4/MAP1A/CUX2"]
["BP","GO:0010769","regulation of cell morphogenesis involved in differentiation",0.043720588606468,"14/323","WDR36/MPL/SYNGAP1/CDK5R1/PAFAH1B1/PREX1/PDPN/SEMA6A/NEDD9/NFATC4/SEMA3C/TUBB2B/CDH2/CUX2"]
["BP","GO:0045446","endothelial cell differentiation",0.043720588606468,"8/323","KDM6B/DLL1/KDR/PDPN/NR2F2/PDE4D/CDH5/APOLD1"]
["BP","GO:0072006","nephron development",0.043720588606468,"9/323","DLL1/GLI3/PODXL/PDGFD/GPR4/SALL1/PDGFRA/PTCH1/SOX9"]
["BP","GO:0071364","cellular response to epidermal growth factor stimulus",0.043720588606468,"5/323","MED1/STAT5B/PTPN11/SOX9/ERRFI1"]
["BP","GO:0007019","microtubule depolymerization",0.0473539548654442,"5/323","TAOK1/CLASP1/KIF2A/MAP1A/NAV3"]
["BP","GO:0001656","metanephros development",0.0473539548654442,"7/323","GLI3/FRAS1/SALL1/PDGFRA/PTCH1/ID3/SOX9"]
["BP","GO:0001101","response to acid chemical",0.0473539548654442,"15/323","ABL2/MMP2/KDR/SESN1/TIE1/PDGFD/SPARC/NFATC4/PDGFRA/FZD4/PTCH1/ID3/CYP26B1/SOX9/COL5A2"]
["BP","GO:0021819","layer formation in cerebral cortex",0.0473539548654442,"3/323","CDK5R1/PAFAH1B1/GLI3"]
["BP","GO:0097104","postsynaptic membrane assembly",0.0473539548654442,"3/323","NLGN2/NLGN4X/CDH2"]
["BP","GO:0098885","modification of postsynaptic actin cytoskeleton",0.0473539548654442,"3/323","MYH10/WASF1/WASF3"]
["BP","GO:0035987","endodermal cell differentiation",0.0483137444369003,"5/323","LAMB1/MMP2/ITGA5/COL5A1/COL5A2"]
["BP","GO:0007173","epidermal growth factor receptor signaling pathway",0.049841353033829,"8/323","FER/STAM/PTPN11/HIP1/SOX9/AFAP1L2/ERRFI1/ADRA2A"]
["BP","GO:0030178","negative regulation of Wnt signaling pathway",0.049841353033829,"11/323","FZD1/ROR2/TMEM170B/NKD1/MCC/DACT1/GLI3/SHISA2/NFATC4/SOX9/CDH2"]
["BP","GO:0098840","protein transport along microtubule",0.049841353033829,"6/323","TERF2/LCA5/BBS12/IFT140/MAP1A/KIF3C"]
["BP","GO:0099118","microtubule-based protein transport",0.049841353033829,"6/323","TERF2/LCA5/BBS12/IFT140/MAP1A/KIF3C"]
["CC","GO:0062023","collagen-containing extracellular matrix",{"v":1.34216033842842e-05,"d":"1.34E-05"},"25/337","LAMB1/LAMC1/ADAMTS4/BGN/MMP2/HMCN1/CILP/TIMP3/GPC6/NID2/COL5A1/ECM2/FBLN2/SPARC/FRAS1/COL6A3/HSPG2/THBS2/LOXL1/THBS1/MFAP4/CDH2/COL5A2/MMRN1/SRPX"]
["CC","GO:0005604","basement membrane",0.000120137179616265,"11/337","LAMB1/LAMC1/HMCN1/TIMP3/NID2/COL5A1/SPARC/FRAS1/HSPG2/THBS2/LOXL1"]
["CC","GO:0098978","glutamatergic synapse",0.042845885156353,"16/337","AP2B1/MYH10/SYNGAP1/DLG4/TANC2/NLGN4X/GRIP1/HIP1/OPHN1/GPC6/SYT1/CRTC1/SPARC/WASF3/FZD4/HTR3A"]
["CC","GO:0030027","lamellipodium",0.0438889420805619,"11/337","APBB2/MYH10/FER/MCC/WASF1/PDPN/PODXL/NEDD9/FGD6/WASF3/CDH2"]
["CC","GO:0031252","cell leading edge",0.0438889420805619,"17/337","APBB2/MYH10/FER/MCC/PAFAH1B1/ITGA5/WASF1/PDPN/KSR1/PODXL/NEDD9/FGD6/MPP2/CDK6/WASF3/MYO1D/CDH2"]
["MF","GO:0005201","extracellular matrix structural constituent",{"v":5.94332505530976e-07,"d":"5.94E-07"},"18/324","LAMB1/LAMC1/BGN/HMCN1/CILP/NID2/COL5A1/FBLN2/SPARC/FRAS1/COL6A3/HSPG2/THBS2/THBS1/MFAP4/COL5A2/MMRN1/SRPX"]
["MF","GO:0008013","beta-catenin binding",0.000618914566936744,"10/324","KDM6B/TCF7L1/DACT1/GLI3/GRIP1/CDH5/SHROOM2/SALL1/SOX9/CDH2"]
["KEGG","hsa04512","ECM-receptor interaction",0.00561278513618777,"9/148","LAMB1/LAMC1/ITGA5/FRAS1/COL6A3/CHAD/HSPG2/THBS2/THBS1"]
["KEGG","hsa04151","PI3K-Akt signaling pathway",0.0168051331950644,"17/148","LAMB1/LAMC1/CREB3L1/ITGA5/KDR/PHLPP2/CCND2/PDGFD/GHR/COL6A3/KIT/CHAD/PDGFRA/CDK6/THBS2/NR4A1/THBS1"]
["KEGG","hsa04510","Focal adhesion",0.0168051331950644,"12/148","LAMB1/LAMC1/ITGA5/KDR/FLNC/CCND2/PDGFD/COL6A3/CHAD/PDGFRA/THBS2/THBS1"]
["KEGG","hsa05205","Proteoglycans in cancer",0.0168051331950644,"12/148","FZD1/MMP2/ITGA5/KDR/TIMP3/PTPN11/FLNC/MRAS/HSPG2/FZD4/PTCH1/THBS1"]

{"sheet":"Sheet5","index":4,"n_rows":100,"n_cols":5,"rows_kept":100,"merged":[[1,0,1,4]],"flags":["formulas_cached_only"]}
["Supply Table 5"]
["Prognosis analysis of 97 phenotype-related genes using a univariate Cox regression model"]
["Gene","HR","HR.95L","HR.95H","pvalue"]
["FTO",1.11839701103685,1.02329723638511,1.22233485034591,0.0135910368705825]
["MED1",1.21141357384461,1.0546375852376,1.39149492435769,0.00668213337089913]
["TGOLN2",1.18229868092458,1.00427883005458,1.39187457614739,0.0442996700950573]
["FAM84A",1.10484366042976,1.00361940661082,1.21627731184873,0.0419863307845511]
["FNDC3A",1.22630881513934,1.05099119822899,1.43087145983957,0.0095475603752465]
["AFF4",1.416608209093,1.16775908411122,1.71848701104049,0.000410173967460465]
["PHACTR2",1.23818423969587,1.09197683270961,1.40396770838721,0.000860971912887321]
["SASH1",1.2428897830436,1.07924872417792,1.43134291307209,0.00253796312945877]
["SHPRH",1.30392823931814,1.07854497886964,1.57640978039991,0.00612697216672745]
["APBB2",1.20709693989447,1.03835493271584,1.40326103954797,0.0142912722181591]
["LAMB1",1.16148475179577,1.03829492326855,1.29929059501445,0.00887323227542323]
["FZD1",1.25956154060495,1.10045058287595,1.44167789018288,0.000810468636339664]
["RCBTB2",1.20021705319392,1.03552986567459,1.39109553720025,0.0153672228385429]
["WDR36",1.15819551244614,1.02754503014102,1.30545796602829,0.0161760053004747]
["ELK3",1.24289735108351,1.10573350352342,1.39707607701848,0.000267819177570612]
["EPHB4",1.10563468359529,1.00426096879612,1.21724142583601,0.040695307495769]
["CIZ1",1.21343524655449,1.05925075382548,1.39006282720413,0.00526810361396015]
["PCDHGC3",1.14660202757677,1.02115181466037,1.28746400953165,0.0206669069733207]
["TEAD1",1.21743123972526,1.05733387048498,1.4017699279596,0.0062387407993166]
["FER",1.16143563475202,1.02840833372192,1.31167036423159,0.0158955775025457]
["OSBPL11",1.16415340777035,1.02626264002876,1.32057146383633,0.0181282170174239]
["LIX1L",1.15503025619205,1.04533434748109,1.27623749849396,0.00464346734320985]
["TMEM200A",1.1228372207668,1.00762844716481,1.25121856958956,0.0359450895069026]
["PRICKLE2",1.20464677000105,1.05466887022127,1.37595209401555,0.00605876512372148]
["CREB3L1",1.13723001632597,1.03224123184596,1.25289716214877,0.00926686191870836]
["PAPOLG",1.16874890136758,1.00259740243158,1.36243520194153,0.0462482531023705]
["ZSCAN29",1.20861141641587,1.04153874028503,1.40248413178662,0.0125551982087933]
["NKD1",1.08847133373607,1.00279794713654,1.1814641700736,0.0426866314357934]
["BGN",1.19681071454384,1.05892069182123,1.35265643358374,0.00401956011728524]
["MN1",1.14065932140996,1.01868943437715,1.27723292655427,0.0225553994696428]
["MCC",1.23714659746752,1.1038443223175,1.38654670108927,0.000253743478712065]
["CDK5R1",1.15425687198072,1.02023253891961,1.30588750671056,0.0227240415189719]
["SMAD9",1.15092773575562,1.02838862653147,1.28806816679727,0.0143918254716045]
["NLGN2",1.22550226681849,1.05985555831004,1.41703819374406,0.00605917048680333]
["HMCN1",1.13988436511736,1.02953510860507,1.26206124976105,0.011726715958278]
["CILP",1.1191516107724,1.0362148960642,1.20872642600656,0.00416319432648745]
["KLF10",1.1731291911745,1.02452012550137,1.34329435306336,0.0208610652996]
["DACT1",1.13836654831926,1.03835406224163,1.24801206587926,0.0057422549028713]
["PAFAH1B1",1.2262195008845,1.06203386438744,1.41578749488999,0.0054263718184905]
["PREX1",1.13944817388624,1.01907170447598,1.27404395124514,0.0219287046733663]
["SPOCK1",1.07228463821445,1.00167605838806,1.14787044745882,0.0446273815774992]
["TANC2",1.11861913632167,1.00503016395879,1.24504598669572,0.040188503947634]
["ITGA5",1.23950579664421,1.07978007786133,1.42285883154801,0.00228480376263369]
["DIP2C",1.13325943316029,1.00434433561956,1.2787217464163,0.0423241107058511]
["TIMP3",1.10579713659155,1.01356753140398,1.20641917722076,0.0236203739474084]
["SH3PXD2B",1.17534605489696,1.03674867583177,1.33247177543154,0.011612563405927]
["AGPAT4",1.17745405113002,1.02978034901131,1.3463046210326,0.016886930317032]
["WISP1",1.13802797974445,1.02545631977162,1.26295743437386,0.0149751220652162]
["GRIP1",1.0989571777616,1.00560380919005,1.20097683353692,0.037220162564156]
["PDPN",1.12487483714196,1.02173461265757,1.23842667514605,0.0164770040294055]
["FLNC",1.18905672301287,1.07135162386407,1.31969360856775,0.0011305130895531]
["ZDHHC17",1.21977391045205,1.0730433823855,1.38656872316926,0.00238110479206088]
["NID2",1.13169440042708,1.03501568300253,1.23740368092072,0.00662063468892261]
["IQSEC1",1.18318747329838,1.06018770726831,1.32045729956376,0.00266836358655443]
["DNMBP",1.10683185004847,1.01430433123801,1.20779997339305,0.0226766676212051]
["C3orf70",1.12957980840244,1.0116495771515,1.261257427837,0.0303232935688368]
["COL5A1",1.13640100181533,1.05248478629262,1.22700798505209,0.00108724861762427]
["MSRB3",1.12726349146936,1.00677690123025,1.2621693819623,0.0377949889516777]
["KSR1",1.17464835591975,1.0456982370653,1.31949993904295,0.00666518109730956]
["ECM2",1.13414491575041,1.01458007716827,1.2678000671101,0.0267859351050229]
["C1QTNF7",1.10963095571904,1.00715408466745,1.22253474084505,0.0353650336853819]
["FBLN2",1.11512429208692,1.02847197503509,1.20907736621596,0.00828603077036709]
["CRNKL1",1.11118430512356,1.00322751126838,1.23075827375572,0.0432013391532916]
["ARL10",1.12593501507984,1.02772309112618,1.23353232901838,0.0108588359859821]
["SVEP1",1.1047831661578,1.02113855876832,1.19527936120428,0.0131119974858406]
["TRIL",1.14497361251824,1.05263948647234,1.24540698901241,0.00160052678209342]
["RNF144A",1.11295890242787,1.01086001594645,1.22536998095992,0.029258635046648]
["XYLT1",1.10533380355063,1.03328256322179,1.18240920805072,0.00359174145657382]
["PDGFD",1.11012754020876,1.00611059852816,1.22489829381861,0.0374039264714111]
["PTCD2",1.13379155829647,1.01659203266491,1.26450262874336,0.0240981845710086]
["ZFHX4",1.23881089192754,1.12563290852541,1.36336847859994,{"v":1.18125337175681e-05,"d":"1.18E-05"}]
["TP53BP1",1.14793886977867,1.03325411081084,1.27535292137829,0.010195728542435]
["COL6A3",1.11076723137451,1.01379437249616,1.21701587202298,0.024202196985245]
["NUAK1",1.2288030718478,1.10578729949984,1.3655040079277,0.000128974284211238]
["CHAD",1.15966709259679,1.06230118675304,1.26595713383547,0.000930559422689399]
["PDGFRA",1.12085616230341,1.02296828327149,1.22811093669079,0.014404933818243]
["CDK6",1.17392010680944,1.06690976922566,1.2916635098127,0.00100890099843399]
["LRRN4",1.11975815857196,1.02904153946189,1.21847203014189,0.00868781650292587]
["SLC35D3",1.14073053495526,1.06175131564202,1.2255846865539,0.000322174590709655]
["MAP1A",1.16746782964231,1.05782847450212,1.2884708306715,0.00208919567263757]
["MGAT5",1.1093358455291,1.01434281817685,1.21322495326349,0.0231013070078488]
["SAMD5",1.11975092803592,1.0144654352966,1.23596339235621,0.0247662476792926]
["NAV3",1.13941602292982,1.03534717244027,1.253945447351,0.00756714918384591]
["IQCE",1.11182478418856,1.00757883544949,1.22685620940468,0.0348348811914722]
["ADAMTS12",1.08932992606232,1.00241941002811,1.18377564913838,0.04370317339869]
["ID3",1.09749060584826,1.00043847802495,1.20395772092159,0.0489250841258053]
["RCOR2",1.10514616834913,1.02095242442636,1.19628302376871,0.0134041543498655]
["WDR25",0.910330629177798,0.844835305969839,0.980903435928174,0.0136596561895634]
["MFAP4",1.11920208826246,1.03928214058434,1.20526781463478,0.00288913551759002]
["CD93",1.08915735428752,1.00115296860155,1.18489759267819,0.0469478719173193]
["AHNAK2",1.09410291662377,1.01455378426894,1.17988933728852,0.0195369236887211]
["MKL1",1.0828611475665,1.00260242529631,1.16954461242449,0.0427531390282464]
["COL5A2",1.11126608310967,1.02785097330978,1.20145073511326,0.00805002766464057]
["ADRA2A",1.07957015803098,1.00263950280526,1.16240355865711,0.0423717117310529]
["EGR3",1.08670071240901,1.01081401998311,1.16828458549673,0.0243740505932666]
["DEFB1",0.943427821772961,0.899632650654692,0.989354993115857,0.0163392907220458]
["EYA4",1.09751229291572,1.02149385798942,1.17918793508164,0.011065003931258]

{"sheet":"Sheet6","index":5,"n_rows":758,"n_cols":12,"rows_kept":758,"merged":[[1,0,1,11]],"flags":["formulas_cached_only"]}
["Supply Table 6"]
["The risk score of each sample"]
["ID","Futime","Fustat","ELK3","AFF4","RCOR2","PHACTR2","CIZ1","NUAK1","MCC","riskScore","risk"]
["TCGA-61-1737",3.73698630136986,0,7.80102678,7.350061357,6.587955702,6.665765137,9.386366522,7.54066304,6.291296035,6.75221315219781,"high"]
["TCGA-09-2054",1.74520547945205,1,7.820341583,8.1404464,10.48985275,7.242632744,9.337715202,7.902189987,6.026829102,7.44444230214369,"high"]
["TCGA-13-0897",5.97808219178082,1,7.364471568,6.788857532,6.803702392,6.931479881,8.629874155,6.230984326,5.407006382,5.60747560894474,"low"]
["TCGA-59-2363",0.452054794520548,0,6.72266553,7.981389401,8.380292626,6.604639041,8.695993576,7.626454986,6.494661854,6.66346138264625,"high"]
["TCGA-61-2003",0.334246575342466,0,8.661181468,7.786108124,7.95276853,7.50316894,9.199576556,7.599047954,6.805074942,7.74423733106452,"high"]
["TCGA-25-2409",2.24931506849315,1,6.808505336,7.777331173,6.443786059,5.665196836,9.204821666,7.077132402,6.577247632,6.2351970484269,"high"]
["TCGA-61-2111",10.4794520547945,0,6.621433302,7.829411849,5.787125842,7.587485411,8.50897151,7.788292688,5.363064612,5.96245887577688,"high"]
["TCGA-25-1315",4.33698630136986,1,6.175572736,6.988459886,9.815539127,6.850931931,8.373779071,6.327008543,6.469910454,5.92985672376946,"high"]
["TCGA-59-A5PD",1.70958904109589,1,7.052031162,7.175670389,9.189180771,6.64952582,9.956518843,6.528879098,4.317871091,5.53051370443495,"low"]
["TCGA-13-0762",9.31506849315068,0,4.088713595,6.680923023,7.313367631,5.289299163,8.266989876,5.744817899,4.262870788,3.99461722414874,"low"]
["TCGA-09-1668",4.61369863013699,0,7.462230878,7.764682164,7.690122539,5.971404593,9.726104016,6.119089934,5.734950102,5.96964175742538,"high"]
["TCGA-23-1109",4.27945205479452,1,6.502976362,6.604794799,7.307251571,5.771752171,10.14540681,6.963898388,5.079331226,5.46999696222058,"low"]
["TCGA-20-1686",0.243835616438356,0,6.079373908,6.195973736,6.55937024,5.988387996,5.312833448,5.169969971,4.941292672,4.33897858646472,"low"]
["TCGA-VG-A8LO",0.0657534246575342,1,7.465131211,8.406341354,8.991147788,7.570384231,9.652878645,6.834085582,5.239043919,6.39659916765061,"high"]
["TCGA-23-1030",2.42739726027397,0,7.229724625,6.685895751,8.94774638,6.261511778,7.97639249,5.831774966,4.659250467,5.22649397008416,"low"]
["TCGA-24-2288",0.0684931506849315,1,6.648451411,8.275875647,6.270459211,7.800646181,8.903771765,6.935572919,6.175589066,6.17153967541938,"high"]
["TCGA-57-1586",1.86027397260274,0,6.784785362,7.075264025,6.949771307,5.597058709,9.221069028,5.876922581,4.830883909,5.07372622748304,"low"]
["TCGA-13-1511",4.52054794520548,1,7.456902769,8.034044401,7.682304586,6.660755298,7.991852008,7.743190195,6.028052601,6.67339334384614,"high"]
["TCGA-13-0766",4.72602739726027,1,4.716045301,6.931767928,6.359080293,5.853491334,7.643869722,5.361842555,5.53483587,4.3927680521556,"low"]
["TCGA-13-1498",5.51232876712329,1,7.271868318,7.006747687,6.570871742,5.662015907,7.568645442,5.869264099,4.320637942,4.89757808592349,"low"]
["TCGA-13-0800",7.29041095890411,0,6.37149137,7.32189294,9.566125324,5.773402391,8.284464972,6.463847157,4.891621118,5.35256666452833,"low"]
["TCGA-04-1519",0.0657534246575342,0,7.319891939,7.072872749,10.50187352,5.16148983,8.559072587,4.677432456,5.775172071,5.44662869618006,"low"]
["TCGA-24-1431",1.5972602739726,1,6.01981051,6.553977278,6.708214164,6.69057688,8.843740278,5.438536006,3.675681403,4.31550111050101,"low"]
["TCGA-23-1119",10.8301369863014,0,6.662838467,7.114735207,7.903710464,6.001812359,6.406383298,6.223911226,4.369276084,4.89992543622607,"low"]
["TCGA-10-0928",1.54246575342466,1,5.847478673,8.109689393,7.679505594,7.989740201,9.587187084,7.026071428,4.676564916,5.48446872357402,"low"]
["TCGA-25-1630",3.18356164383562,1,7.810929202,6.804658901,6.556513618,6.385372835,8.394964295,6.499639472,5.163603101,5.67803586229448,"low"]
["TCGA-13-0768",4.88767123287671,1,7.190313842,7.242051125,6.509367164,7.242933277,7.584386975,6.682077804,6.581699879,6.16576344985036,"high"]
["TCGA-24-1422",0.063013698630137,1,7.876558992,8.322766751,6.996632372,7.38796287,8.216553927,8.400672007,6.707365807,7.54866975198713,"high"]
["TCGA-25-1634",2.98904109589041,1,6.993750411,7.581005106,9.508151468,6.715906203,8.07288431,5.465262916,4.352948261,5.1286760930818,"low"]
["TCGA-29-1695",3.36712328767123,1,7.03103819,7.626260321,8.977740282,6.877803627,8.18236144,7.987929245,5.061409824,6.27136400354522,"high"]
["TCGA-30-1714",3.17260273972603,1,6.341576325,6.853316591,6.977009225,5.910948115,6.647138292,5.280079404,4.436654587,4.46507634657839,"low"]
["TCGA-30-1891",2.5041095890411,1,6.344368289,7.226066495,5.987419162,6.163460118,8.499015733,6.997615429,5.691411635,5.53096460065142,"low"]
["TCGA-13-1405",2.37808219178082,1,8.350218869,7.269343377,6.416208221,6.402456318,9.346382719,7.45376806,6.474377663,6.97781467124665,"high"]
["TCGA-30-1860",3.74246575342466,1,6.179785993,6.673704654,5.203120495,5.382352344,8.884591678,6.273163712,4.780075047,4.75570420714461,"low"]
["TCGA-36-1581",2.05753424657534,0,6.653489146,8.035091329,7.586376194,7.181481197,8.452733291,7.596597703,5.744126021,6.24073991510144,"high"]
["TCGA-13-0893",3.61369863013699,1,6.492285245,7.369055689,7.613997507,6.017983609,8.821833942,5.865846347,7.425895344,6.08190345665998,"high"]
["TCGA-23-2077",9.65753424657534,0,6.824818677,6.621907918,9.226333045,6.539022971,8.339849105,5.203890875,5.777772245,5.36748189182254,"low"]
["TCGA-24-1923",1.89041095890411,1,5.776474658,7.019245195,5.458736585,6.497864222,8.996405818,5.971483526,8.117418114,5.92646777783169,"high"]
["TCGA-24-2036",5.33424657534247,1,6.250483924,8.049666914,8.757393003,6.108396448,8.967030259,6.175485923,6.618777644,6.00110765056935,"high"]
["TCGA-13-0804",2.93972602739726,1,6.802513625,6.584933049,6.562044248,5.442809759,7.690388719,5.815346701,4.544864849,4.75579997502538,"low"]
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["GSM4154143",2.0958904109589,0,8.062254375,7.928858043,8.249685423,7.446497266,9.807709889,5.593997468,5.253471307,6.0202354862159,"high"]
["GSM4154144",2.08767123287671,0,7.416634202,8.445915021,6.267853794,8.458156308,9.00549821,5.013964552,6.65074839,6.05009156639539,"high"]
["GSM4154145",1.79178082191781,0,6.78559296,7.531936654,8.043721612,6.241593988,9.123371856,6.564821834,6.710870097,6.26519997515192,"high"]
["GSM4154146",1.85753424657534,0,4.966843234,7.624094279,7.601146521,6.422148971,9.911689294,7.087933889,5.587618422,5.37627246563052,"low"]
["GSM4154147",1.62465753424658,0,7.52784609,8.401190321,6.731603968,7.152515625,8.138458217,8.196009207,5.429101061,6.62363478177813,"high"]
["GSM4154148",0.0493150684931507,0,7.307986058,7.502221947,8.041643779,6.221403799,9.041330757,6.395340431,6.163513263,6.15476203147414,"high"]
["GSM4154149",1.71232876712329,0,5.966314837,8.157528533,7.982502482,6.220033675,8.639810632,8.255370404,6.149629265,6.38754795458497,"high"]
["GSM4154150",1.8027397260274,0,6.394991952,7.591400128,7.806756851,7.19717323,9.591544851,6.436056502,7.49514178,6.52245609654257,"high"]
["GSM4154151",1.3013698630137,1,7.466909005,7.982824386,6.992932457,6.551778452,9.264264014,7.934948189,6.541622465,7.02466126445346,"high"]
["GSM4154152",1.76712328767123,0,6.768486094,8.529669611,8.525366861,7.957020307,9.138116827,7.174043715,7.294009242,7.16930594625489,"high"]
["GSM4154153",1.74794520547945,0,7.145534494,7.886715619,6.473166079,6.664605352,8.390815501,7.558227601,6.690967863,6.65371480488765,"high"]
["GSM4154154",1.76712328767123,0,5.281236527,7.591876825,8.169441421,5.85739024,9.320234641,6.268542603,5.794461712,5.25320017376165,"low"]
["GSM4154155",1.75616438356164,0,7.229415683,7.338191702,7.398190381,6.730350943,8.689634821,7.468669925,5.136108327,6.00965450200251,"high"]
["GSM4154156",1.75342465753425,0,7.569174114,7.101596223,7.464684588,6.164332003,8.304994923,6.3408797,4.738603154,5.47499985250124,"low"]
["GSM4154157",1.56164383561644,0,6.636295616,7.645026021,8.339092424,6.245767937,7.025639916,6.451935772,6.419602622,5.91353101382627,"high"]

{"sheet":"Sheet7","index":6,"n_rows":28,"n_cols":4,"rows_kept":28,"merged":[[1,0,1,3]],"flags":["formulas_cached_only"]}
["Supply Table 7"]
["The validated and potential targets of m6A RNA methylation regulators"]
["Target Gene","WER Name","Class","Downstream Effect"]
["ELK3","METTL14","Writer","expression"]
["ELK3","METTL3","Writer","methylation"]
["AFF4","METTL3","Writer","AS; expression; methylation; translation"]
["AFF4","FTO","Eraser","AS"]
["NUAK1","METTL14","Writer","expression"]
["NUAK1","METTL3","Writer","methylation"]
["NUAK1","WTAP","Writer","methylation"]
["MCC","METTL14","Writer","expression"]
["MCC","METTL3","Writer","expression;translation"]
["MCC","FTO","Eraser","methylation"]
["RCOR2","YTHDC2","Reader","expression"]
["RCOR2","METTL14","Writer","AS; expression"]
["RCOR2","METTL3","Writer","methylation"]
["RCOR2","FTO","Eraser","expression"]
["PHACTR2","METTL14","Writer","expression; AS"]
["PHACTR2","METTL3","Writer","AS; expression; methylation; translation"]
["PHACTR2","FTO","Eraser","AS"]
["PHACTR2","ZC3H13","Writer","methylation"]
["CIZ1","METTL14","Writer","AS; expression; methylation"]
["CIZ1","METTL3","Writer","AS; expression; methylation"]
["CIZ1","FTO","Eraser","methylation"]
["CIZ1","ZC3H13","Writer","methylation"]
["CIZ1","WTAP","Writer","AS; methylation"]
["WER: writer, eraser, reader"]
["AS: alternative splicing"]