{"text_format":"3","workbook":"xls","n_sheets":4,"sheets":["Table S1","Table S2","Table S3","Table S4"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Table S1","index":0,"n_rows":103,"n_cols":3,"rows_kept":103,"flags":["formulas_cached_only"]}
["Supplemental Table S1. The list of gene sets."]
[]
[]
["ERS genes",null,"Check-point genes"]
["ACADVL",null,"IDO1"]
["ADD1",null,"LAG3"]
["AGR2",null,"CTLA4"]
["ARFGAP1",null,"TNFRSF9"]
["ATP6V0D1",null,"ICOS"]
["BAK1",null,"CD80"]
["BAX",null,"PDCD1LG2"]
["BCL2L11",null,"TIGIT"]
["BFAR",null,"CD70"]
["COPS5",null,"TNFSF9"]
["CTDSP2",null,"ICOSLG"]
["CUL7",null,"KIR3DL1"]
["CXXC1",null,"CD86"]
["DAB2IP",null,"PDCD1"]
["DCTN1",null,"LAIR1"]
["DDRGK1",null,"TNFRSF8"]
["DDX11",null,"TNFSF15"]
["DNAJB11",null,"TNFRSF14"]
["DNAJB9",null,"IDO2"]
["DNAJC3",null,"CD276"]
["EDEM1",null,"CD40"]
["ERN1",null,"TNFRSF4"]
["ERN2",null,"TNFSF14"]
["EXTL1",null,"HHLA2"]
["EXTL2",null,"CD244"]
["EXTL3",null,"CD274"]
["FICD",null,"HAVCR2"]
["FKBP14",null,"CD27"]
["GET3",null,"BTLA"]
["GFPT1",null,"LGALS9"]
["GOSR2",null,"TMIGD2"]
["GSK3A",null,"CD28"]
["HDGF",null,"CD48"]
["HSPA5",null,"TNFRSF25"]
["HYOU1",null,"CD40LG"]
["KDELR3",null,"ADORA2A"]
["KLHDC3",null,"VTCN1"]
["LMNA",null,"CD160"]
["MYDGF",null,"CD44"]
["PARP16",null,"TNFSF18"]
["PDIA5",null,"TNFRSF18"]
["PDIA6",null,"BTNL2"]
["PLA2G4B",null,"C10orf54"]
["PPP2R5B",null,"CD200R1"]
["PREB",null,"TNFSF4"]
["PTPN1",null,"CD200"]
["SEC31A",null,"NRP1"]
["SERP1"]
["SHC1"]
["SRPRA"]
["SRPRB"]
["SSR1"]
["SULT1A3"]
["SULT1A4"]
["SYVN1"]
["TATDN2"]
["TLN1"]
["TMEM33"]
["TPP1"]
["TSPYL2"]
["UFL1"]
["VAPB"]
["WFS1"]
["WIPI1"]
["XBP1"]
["YIF1A"]
["ZBTB17"]
["ASNS"]
["ATF3"]
["ATF4"]
["ATF6"]
["CCL2"]
["CEBPB"]
["CEBPG"]
["CXCL8"]
["DCP2"]
["DDIT3"]
["DIS3"]
["EXOSC1"]
["EXOSC2"]
["EXOSC3"]
["EXOSC4"]
["EXOSC5"]
["EXOSC6"]
["EXOSC7"]
["EXOSC8"]
["EXOSC9"]
["HERPUD1"]
["IGFBP1"]
["KHSRP"]
["NFYA"]
["NFYB"]
["NFYC"]
["PARN"]
["ATF6B"]
["CALR"]
["HSP90B1"]
["MBTPS1"]
["MBTPS2"]

{"sheet":"Table S2","index":1,"n_rows":101,"n_cols":5,"rows_kept":101,"flags":["formulas_cached_only"]}
["Supplemental Table S2. The difference of the expression levels of 98 ERS-related genes between normal and tumor samples."]
[]
[]
["Gene","F","Sig.","t","df"]
["EXTL1",206.4991,{"v":6.61e-40,"d":"6.61E-40"},8.527505,542]
["ERN2",57.63663,{"v":1.39e-13,"d":"1.39E-13"},4.229211,542]
["AGR2",34.11768,{"v":8.95e-09,"d":"8.95E-09"},3.008987,542]
["ASNS",22.37632,{"v":2.86e-06,"d":"2.86E-06"},-7.36346,542]
["EXOSC2",14.43803,0.000161,-10.301,542]
["EXOSC5",13.56296,0.000254,-6.68298,542]
["COPS5",11.267,0.000844,-9.21954,542]
["FKBP14",10.47791,0.001282,-9.31252,542]
["EXOSC7",10.3245,0.001391,-4.44995,542]
["EXOSC8",10.08104,0.001583,-7.10474,542]
["YIF1A",8.614596,0.003476,-10.7409,542]
["DCTN1",7.942363,0.005005,-6.27158,542]
["PREB",6.80378,0.009347,-5.40872,542]
["DDX11",6.671145,0.01006,-10.5792,542]
["MBTPS2",6.455352,0.01134,-4.76203,542]
["BAX",6.293956,0.012406,-12.9178,542]
["ACADVL",6.286436,0.012458,5.685526,542]
["EXOSC9",6.209892,0.013002,-9.35448,542]
["LMNA",6.02593,0.01441,-6.60223,542]
["TLN1",5.935988,0.015156,-4.26637,542]
["CALR",4.945716,0.026567,-13.6833,542]
["DNAJB11",4.72582,0.030145,-12.7162,542]
["ZBTB17",4.717604,0.030288,-10.4849,542]
["KDELR3",4.685712,0.03085,-8.57213,542]
["VAPB",4.466379,0.035025,-5.47148,542]
["PARP16",4.282694,0.038976,-3.28037,542]
["DDIT3",4.050781,0.044645,-7.9171,542]
["PLA2G4B",3.964372,0.046974,-5.0994,542]
["CUL7",3.731568,0.053914,-5.58462,542]
["ATF4",3.661978,0.056194,-3.40079,542]
["NFYC",3.102229,0.078749,-3.37562,542]
["ADD1",3.095359,0.07908,-2.20319,542]
["NFYB",3.077056,0.079969,-5.57037,542]
["EXTL2",2.942033,0.086874,-8.30934,542]
["TATDN2",2.40831,0.121276,-4.18157,542]
["IGFBP1",2.398001,0.122074,-5.71512,542]
["CTDSP2",2.373009,0.124033,-3.84779,542]
["KLHDC3",2.353123,0.125616,-5.20207,542]
["HERPUD1",2.287441,0.131008,-0.24461,542]
["PDIA5",2.108788,0.147034,-12.4906,542]
["CXXC1",2.079022,0.149913,-5.6396,542]
["EXTL3",2.072814,0.150522,-10.0117,542]
["TPP1",1.880328,0.170864,-6.85943,542]
["TSPYL2",1.828347,0.176887,-3.35245,542]
["EXOSC3",1.824048,0.177396,-9.10162,542]
["SULT1A4",1.750661,0.186352,-7.05936,542]
["EXOSC6",1.724857,0.189625,-6.47921,542]
["DAB2IP",1.605187,0.205714,-5.55399,542]
["FICD",1.598007,0.206729,-3.96653,542]
["EXOSC1",1.56885,0.210914,-9.32285,542]
["WIPI1",1.551629,0.213433,-0.05831,542]
["SULT1A3",1.530625,0.216554,-7.90861,542]
["CCL2",1.441851,0.230365,5.485604,542]
["GOSR2",1.326091,0.250009,-10.465,542]
["CEBPB",1.235705,0.266793,-8.02907,542]
["HDGF",1.17327,0.279212,-12.7596,542]
["ATP6V0D1",1.147103,0.284633,-4.23535,542]
["DCP2",1.12335,0.28967,-6.97764,542]
["BCL2L11",1.100827,0.294552,-6.63713,542]
["DIS3",1.046847,0.306691,-4.82325,542]
["WFS1",0.977244,0.323321,-6.86121,542]
["DNAJC3",0.892177,0.345309,-2.24949,542]
["SHC1",0.88418,0.347478,-10.2346,542]
["EXOSC4",0.863757,0.353103,-9.72572,542]
["SERP1",0.83506,0.36122,-9.08178,542]
["SEC31A",0.793769,0.373358,-3.05827,542]
["SYVN1",0.762952,0.382793,-7.09207,542]
["CEBPG",0.751103,0.386511,-6.92525,542]
["BFAR",0.727127,0.394193,-10.3821,542]
["ARFGAP1",0.722301,0.395765,-14.3626,542]
["DNAJB9",0.614879,0.433299,-2.35906,542]
["HSP90B1",0.527825,0.467836,-12.7834,542]
["GFPT1",0.503626,0.478217,-2.10484,542]
["NFYA",0.472401,0.492179,-8.75382,542]
["SSR1",0.458786,0.498481,-7.93278,542]
["DDRGK1",0.27914,0.597481,-4.90266,542]
["GSK3A",0.269284,0.604025,-9.74658,542]
["PTPN1",0.267081,0.605508,-8.14672,542]
["ATF3",0.249764,0.617444,0.946118,542]
["PDIA6",0.241529,0.623303,-8.69741,542]
["ATF6B",0.238855,0.625232,-6.00909,542]
["UFL1",0.192779,0.660789,1.884187,542]
["BAK1",0.180848,0.670814,-10.3112,542]
["SRPRA",0.17071,0.679645,-1.74308,542]
["MYDGF",0.135157,0.713287,-9.77419,542]
["TMEM33",0.098005,0.754357,-6.24443,542]
["HYOU1",0.095139,0.757861,-5.40861,542]
["PPP2R5B",0.039261,0.843006,-7.27544,542]
["HSPA5",0.037175,0.847181,-9.86032,542]
["KHSRP",0.028945,0.86497,-7.72714,542]
["MBTPS1",0.026945,0.869676,-5.21621,542]
["EDEM1",0.015537,0.900849,-5.81278,542]
["SRPRB",0.010937,0.916749,-6.56492,542]
["PARN",0.002191,0.962683,-12.6871,542]
["CXCL8",0.001974,0.964574,-6.3717,542]
["ERN1",0.000646,0.979736,-1.21794,542]
["ATF6",0.000639,0.979843,-3.90382,542]

{"sheet":"Table S3","index":2,"n_rows":101,"n_cols":4,"rows_kept":101,"flags":["formulas_cached_only"]}
["Supplemental Table S3. The list of 19 genes related to OS of HNSCC in univariate Cox regression analysis."]
[]
[]
["Gene","HR","z","pvalue"]
["HSPA5",13.1313314,3.071866074,0.002127251]
["ASNS",2.034367449,2.826719854,0.004702745]
["FKBP14",2.163600302,2.720435369,0.006519602]
["BFAR",4.181217998,2.653028016,0.007977325]
["EXOSC6",3.941340626,2.618536108,0.008830795]
["EXOSC1",5.030502315,2.612300553,0.008993515]
["PARN",4.922550874,2.566098527,0.010284961]
["BAK1",3.388038046,2.535092897,0.011241751]
["TPP1",3.490236198,2.491723207,0.012712506]
["SRPRB",4.030575413,2.402359646,0.016289684]
["HSP90B1",7.324101038,2.384998702,0.017079182]
["ATF6",3.508530327,2.354240531,0.018560597]
["PDIA6",3.34695746,2.275343017,0.022885361]
["EXOSC8",2.794458792,2.255135567,0.024124821]
["DNAJB11",3.055139916,2.249002602,0.024512331]
["SHC1",3.536891387,2.206326144,0.027361172]
["TATDN2",0.377417994,-2.108195323,0.035014098]
["YIF1A",3.461626915,2.054720533,0.039906006]
["EXOSC2",2.347091333,2.038753095,0.041474676]
["VAPB",2.4692509,1.946580102,0.051585096]
["CXCL8",1.38111842,1.893642743,0.058272446]
["DIS3",1.942702763,1.834727351,0.066546098]
["MBTPS2",1.687898586,1.81694018,0.069226273]
["PREB",3.679569074,1.766974253,0.07723254]
["DNAJC3",2.169850279,1.725491317,0.084438967]
["COPS5",2.506363109,1.680239192,0.092910787]
["KDELR3",1.459672742,1.671292918,0.094663835]
["CXXC1",0.441436021,-1.657379203,0.097442833]
["EXOSC3",1.962595908,1.651378401,0.098661332]
["SULT1A4",1.95929882,1.63902331,0.101208405]
["IGFBP1",1.555146107,1.612558141,0.106840539]
["CALR",6.603545458,1.61012547,0.107370468]
["PDIA5",1.669948163,1.60174972,0.109210966]
["EXTL1",1.433496027,1.590316123,0.111763566]
["CEBPG",2.468700951,1.578810184,0.114379602]
["SRPRA",2.600633213,1.572961852,0.115727652]
["ATP6V0D1",2.815301755,1.54683583,0.121902838]
["GFPT1",1.763845103,1.542473035,0.122958686]
["EXOSC9",1.99258515,1.514315031,0.129945958]
["DDIT3",1.530245583,1.509934048,0.131060254]
["HYOU1",1.771392709,1.483451088,0.137954603]
["PTPN1",2.102668624,1.451663939,0.146595071]
["DCP2",0.620162549,-1.445955105,0.148189794]
["ATF6B",2.140734041,1.436689241,0.150806313]
["EXTL2",1.408345349,1.425790815,0.153928733]
["SULT1A3",1.774580618,1.398772413,0.161881241]
["EXOSC7",1.958735333,1.359103035,0.174113941]
["EXOSC4",1.898431636,1.348076692,0.177633717]
["CEBPB",1.950785308,1.298644643,0.19406591]
["DDX11",0.735746914,-1.278929937,0.200921729]
["GOSR2",2.027272736,1.2071945,0.227357248]
["ERN2",0.832469927,-1.188334455,0.234701668]
["MYDGF",2.152819255,1.154872651,0.24814258]
["WIPI1",1.356581849,1.121047979,0.26226744]
["AGR2",0.881147335,-1.090501736,0.275492189]
["PLA2G4B",0.760522353,-1.090063702,0.275685084]
["SERP1",2.303807931,1.077602948,0.281210986]
["ATF4",2.264363298,0.996799071,0.318862049]
["DCTN1",1.850927275,0.965808613,0.334139958]
["BCL2L11",0.772765305,-0.956292828,0.338924312]
["TMEM33",1.569018975,0.952199111,0.340996012]
["GSK3A",2.107208405,0.95067166,0.341771079]
["HERPUD1",0.701710372,-0.947169762,0.343552281]
["UFL1",1.373342175,0.9108191,0.362390697]
["DDRGK1",1.792426551,0.873590867,0.382341102]
["ATF3",1.16591637,0.797656513,0.425069846]
["ZBTB17",0.702627189,-0.59053764,0.554830259]
["HDGF",1.635669547,0.543793086,0.586583867]
["FICD",0.873737989,-0.543201217,0.586991268]
["DAB2IP",1.227869621,0.533773326,0.593498371]
["DNAJB9",1.236700581,0.533747069,0.593516539]
["ERN1",1.172218381,0.532094091,0.59466083]
["MBTPS1",1.250406624,0.517930365,0.604506855]
["BAX",1.39254936,0.500466671,0.616746518]
["CUL7",0.844340632,-0.498522025,0.618116149]
["LMNA",0.649970303,-0.479334564,0.631700637]
["SEC31A",1.23519116,0.464300287,0.642432618]
["PARP16",0.889191002,-0.419493311,0.674855642]
["TLN1",1.168593117,0.41891914,0.675275229]
["NFYB",1.154538685,0.395334741,0.692595864]
["PPP2R5B",1.179344677,0.378966127,0.704713018]
["KLHDC3",0.778029522,-0.370027641,0.711361895]
["ARFGAP1",1.219722551,0.358340357,0.72008862]
["KHSRP",0.817665302,-0.340266846,0.733655582]
["TSPYL2",1.073720151,0.316611103,0.75153871]
["NFYC",0.856699273,-0.283718609,0.776626033]
["EDEM1",1.107881116,0.278942162,0.780289212]
["CTDSP2",0.886916049,-0.271476289,0.786024734]
["WFS1",0.931772006,-0.229389337,0.818566323]
["ACADVL",0.868337489,-0.211700447,0.832340739]
["EXTL3",1.070906415,0.166983109,0.867383339]
["ADD1",0.937134796,-0.123369266,0.901814694]
["NFYA",1.044454544,0.116799148,0.907019219]
["SYVN1",1.053171284,0.097413209,0.922398255]
["SSR1",1.029747179,0.052944731,0.957775944]
["EXOSC5",1.024064253,0.049755253,0.960317426]
["CCL2",1.004059711,0.021295799,0.983009695]

{"sheet":"Table S4","index":3,"n_rows":18,"n_cols":3,"rows_kept":18,"flags":["formulas_cached_only"]}
["Supplemental Table S4. The correlation of the ERS-related signature with clinical characteristics of HNSCC."]
[]
[]
["Riskscore","R","P-value"]
["Survival status",0.259906940056494,{"v":3.66104397073902e-09,"d":"3.66E-09"}]
["Sex",0.009203875603394607,0.8373423078051169]
["Age",0.0680915477679406,0.1283784209046989]
["T","0.090*",0.043777703045482175]
["N",-0.07203605944921807,0.10765257096130372]
["M",0.05661016693724003,0.20634235017257635]
["Stage",-0.00797042533711613,0.8588950645635364]
["Grade",0.0014207811533126094,0.9747191638313033]
["Cancer_Status","0.207**",3.1032052012669347e-06]
["Alcohol_history_documented",0.05318578928983389,0.23517470795496578]
["Ethnicity",0.023258122182778413,0.6038751507473626]
["Treatment_response",-0.119,0.007556233736783726]
["Lymphnode_neck_dissection",0.08696258616651775,0.05220924604585812]
["Perineural_invasion_present","0.126**",0.0048301623745339636]