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[null,"Table S1. Study design and patient characteristics of included studies"]
[null,"Study ID","Beigel 2020[10]a","Wang 2020[11]","Spinner 2020[13]","Goldman 2020[14]b","Grein 2020[15]","Olender 2020[16]","Antinori 2020[17]"]
[null,"Interventions (n)","10-day Remdesivir(541) \n       vs \nPlacebo(521)","10-day Remdesivir (158) \n      vs \nPlacebo(78)","5-day Remdesivir(191) \n       vs \n10-day Remdesivir(193) \n       vs \nPlacebo(200)","5-day Remdesivirs(200) \n       vs \n10-day  Remdesivir(197)","Invasive ventilation+ Remdesivir(34) \n      vs \nNoninvasive oxygen support+Remdesivir(19)","Remdesivir(312) \n     vs \nNon-Remdesivir(818)","Intensive care unit(18) \nvs \nInfectious diseases ward (17)"]
[null,"Type of study","randomized, double-blind trial","randomized,double-blind,multicentre trial","randomized, open-label trial","randomized, open-label, phase 3 trial","cohort study","cohort study","observational study"]
[null,"Follow-up period","28 days","28 days","28 days","14 days","36 days","14 days","28 days"]
[null,"Age(median, IQR)","58.6±14.6 \n     vs \n59.2±15.4","66 (57-73) \n    vs \n64 (53-70)","58 (48-66) \n     vs \n56 (45-66) \n     vs \n57 (45-66)","61 (50-69) \n     vs \n62 (50-71)","67 (56-72) \n     vs \n53 (41-68)","NA","61 (49-64) \n      vs \n64 (51-75)"]
[null,"Sex(Male,%)","65.1 vs 63.7","56.3 vs 65.4","59.7 vs 61.1 vs 62.5","60.0 vs 67.5","79.4 vs 68.4","59.0 vs 59.0","77.8 vs 70.6"]
[null,"Outcome indicators"]
[null,"Clinical improvement(median, IQR)","11 (10-13) \n     vs \n14 (13-15)","NA","6 (5-14) \n     vs \n8 (4-14) \n     vs \n8 (5-22)","NA","NA","NA","NA"]
[null,"Modified recovery,days(median, IQR)","10 (9-11) \n     vs \n15 (13-18)","NA","6 (4-9) \n     vs \n7 (4-12) \n     vs \n7 (4-14)","9 vs 10","NA","NA","NA"]
[null,"Clinical improvement(n)"]
[null,"7-day","NA","4 vs 2","106 vs 92 vs 94","71 vs 54","NA","NA","NA"]
[null,"14-day","326 vs 257","42 vs 18","146 vs 148 vs 135","129 vs 107","NA","232 vs 483","NA"]
[null,"28-day","399 vs 352","103 vs 45","171 vs 174 vs 166","NA","19 vs 17","NA","NA"]
[null,"Adverse events(n)","305 vs 323","102 vs 50","98 vs 113 vs 93","141 vs 145","22 vs 10","NA","NA"]
[null,"Grade 3 or 4 adverse events(n)","273 vs 295","13 vs 11","20 vs 24 vs 24","61 vs 84","NA","NA","17 vs 15"]
[null,"Serious adverse events(n)","131 vs 163","28 vs 20","9 vs 10 vs 18","42 vs 68","9 vs 3","NA","NA"]
[null,"Death(n)","59 vs 77","22 vs 10","2 vs 3 vs 4","16 vs 21","6 vs 1","24 vs 102","NA"]
[null,"Abbreviations：IQR, interquartile range; NA, not available.\na Age was expressed as mean ± standard deviation .\nb Modified recovery was expressed as only median."]