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["Supplementary Figure1","The stable upregulation and downregulation of 15-LOX-2 cell lines were constructed."]
[null,"(a, c, e) Cells expressed with shRNA or sgRNA were all labeled by GFP.(b, d, f) The scatter figures showed all cells for experiment with more than 90% GFP. Results are presented as the mean ±SD (n=3)."]
["Supplementary Figure2","15-LOX-2 deficiency enhances the macrophages phagocytosis of lipid droplets."]
[null,"(a) Oil Red O staining of cells, scale bar,100μm, black arrows show lipid droplets in different cells."]
["Supplementary Figure3","The efficiency of CRISPRa on RAW264.7 and HUEVCs."]
[null,"(a) Vector schematic of plenti-CRISPRa showing constitutive Vector (AtTA) and inducible (TRE) transcripts produced by the vector. IRES-dependent AtTA expression from the constitutive transcript creates a positive feedback loop of TRE induction to indicate the two viruses are coinfected with the cells.(b) The upregulation efficiency of 15-LOX-2 by CRISPRa in RAW264.7 was detected by WB and quantitated using ImageJ, compared to scramble.(c) The upregulation efficiency of 15-LOX-2 by CRISPRa in HUEVCs was detected by WB and quantitated using ImageJ, compared to scramble."]
["Supplementary Figure4","Upregulation of 15-LOX-2 induced the downregulation of CypB on cells."]
[null,"(a, b) The expression of CypB in RAW264.7-CRISPRa-15-LOX-2 and Scramble was detected by WB and quantitated using ImageJ. Results are presented as the mean ±SD（n=3）, *:P<0.05, **:P<0.001, VS Scramble. (c) The expression of CypB in HUEVCs-CRISPRa-15-LOX-2 was detected by WB and quantitated using ImageJ."]
["Supplementary Figure5","Upregulation of 15-LOX-2 contributes to the upregulation of caspase3 in cells."]
[null,"(a, b) The expression of caspase3 in RAW264.7-CRISPRa-15-LOX-2 and Scramble was detected by WB and quantitated using ImageJ. Results are presented as the mean ±SD（n=3）, *:P<0.05, VS Scramble. (c, d) The expression of caspase3 in HUEVCs-CRISPRa-15-LOX-2 and Scramble was detected by WB and quantitated using ImageJ. Results are presented as the mean ±SD（n=3）, *:P<0.05, VS Scramble."]
["Full-length of Blots"]
["Figure 1b","The knockdown efficiency of 15-LOX-2 by shRNA in Ana-1"]
["Figure 3a","The expression of CypB in Ana-1- sh15-LOX-2 and shRen"]
["Figure 3c","The expression of caspase-3 in Ana-1-sh15-LOX-2 and shRen"]
["Figure 5b","CypB levels in sh15-LOX-2 and shRen macrophages treated with salidroside"]
["Figure 5d","Caspase-3 levels in sh15-LOX-2 and shRen macrophages treated with salidroside"]
["Supplementary Figure 3b","The upregulation efficiency of 15-LOX-2 by CRISPRa in RAW264.7"]
["Supplementary Figure 3c","The upregulation efficiency of 15-LOX-2 by CRISPRa in HUEVCs"]
["Supplementary Figure 4a","The expression of CypB in RAW264.7-CRISPRa-15-LOX-2 and Scramble"]
["Supplementary Figure 4c","The expression of CypB in HUEVCs-CRISPRa-15-LOX-2 and scramble"]
["Supplementary Figure 5a","The expression of caspase3 in RAW264.7-CRISPRa-15-LOX-2 and Scramble"]
["Supplementary Figure 5c","The expression of caspase3 in HUEVCs-CRISPRa-15-LOX-2 and Scramble"]