{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Sheet1","Sheet2","Sheet3"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":17,"n_cols":3,"rows_kept":17,"merged":[[0,0,0,2],[8,0,11,0],[8,1,11,1]],"flags":["formulas_cached_only"]}
["Characteristics of hepatic sarcomatoid carcinoma and gastrointestinal stromal tumors"]
["Characteristics","  Hepatic sarcomatoid carcinoma","Gastrointestinal stromal tumor"]
["Benign/malignant","malignant[1,2]","depends on site and mitotic activity[36]"]
["Percentage","about 0.2% of  hepatic cancer[18]","about 1% of gastrointestinal tumors"]
["Histological sources","monoclonal origin, still controversial[5]","Cajal mesenchymal cells[37,38], pluripotent mesenchymal stem cells[39]"]
["Etiology and pathogenesis","sarcoma-like transformation of HCC (mainstream),            hepatic cancer and sarcoma combined (other) [9]","KIT receptor activation (mainstream),                                                         PDGFRA mutation activation (other) [40]"]
["Occurrence site","right lobe＞left lobe＞tail lobe[17]","stomach＞small Intestine＞colon＞rectum＞esophagus[41,42,43,44]"]
["Classification","SHC、ISCC、undifferentiated carcinoma[45,24]","spindle cell type, epithelioid type and mixed type[46,47]"]
["Clinical manifestations","abdominal pain (most common), fatigue, fever, jaundice, weight loss, nausea, vomiting, etc.[9,4,48]","small size can be asymptomatic;   large size varies according to the location;"]
[null,null,"stomach and small intestine: abdominal pain, gastrointestinal bleeding, abdominal mass [49,50];"]
[null,null,"colon: acute abdomen, perforation, pain, obstruction[51];"]
[null,null,"esophagus: dysphagia[52];"]
["Distant metastasis","lung (most common), peritoneum, pleura, pancreas, adrenal gland, intestine, and spleen[53,18,54,55,56]；","liver (63%) and peritoneum (21%)[57]"]
["Preoperative diagnosis","Enhanced MRI, ultrasound-guided percutaneous liver puncture, etc.[20,17]","endoscopic ultrasound (EUS), ultrasonic directed fine needle aspiration (EUS- FNA), etc.[40,58]"]
["Treatment","early stage: surgical radical resection [20];                           middle and late stage: radiotherapy, chemotherapy, hyperthermia, etc. [20];","depends on the size and location of the tumor;                                              esophagus: >2cm,resection;<2cm,controversial;[59,60]                             stomach: <1cm,conservative;1-2cm, controversial; >2cm, resection;                                                                                                      duodenum: pancreaticoduodenectomy [61];                                              colon and rectum: neoadjuvant (imatinib) + surgery [62,44,63]"]
["Immunohistochemistry（main)","Vim（+）、CK（+）[31,32]","CD117（+）、CD34（+）、Dog-1（+）[64,65]"]
["Gene mutation","P53[66]","KIT/PDGFRA[67,68,69]"]

{"sheet":"Sheet2","index":1,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}

{"sheet":"Sheet3","index":2,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}