Project info 1

Project info 1 Experiment Date2021-09-01 Experiment ID Notebook ID Project Experimenter Protocol SIRT1 Control 14.3 15.2 14.75 14.3 15.2 14.75 DOX 5.4 5.9 5.65 5.4 5.9 5.65 ACA+DOX 6.4 8.1 7.25 6.4 8.1 7.25 B.Cereus+DOX 11.8 10.9 11.35 11.8 10.9 11.35

FOXO1 Control 1.13 1.24 1.185 1.13 1.24 1.185 DOX 4.32 3.98 4.15 4.32 3.98 4.15 ACA+DOX 2.89 3.54 3.215 2.89 3.54 3.215 B.Cereus+DOX 0.98 1.42 1.2 0.98 1.42 1.2

17B-HSD Control 5.42 7.22 6.32 5.42 7.22 6.32 DOX 1.87 1.65 1.76 1.87 1.65 1.76 ACA+DOX 2.11 1.97 2.04 2.11 1.97 2.04 B.Cereus+DOX 3.89 4.66 4.275 3.89 4.66 4.275

SOD Control 7.5 7.5 7.5 7.5 7.5 7.5 DOX 1.25 2.5 1.875 1.25 2.5 1.875 ACA+DOX 5 3.75 4.375 5 3.75 4.375 B.Cereus+DOX 6.25 5 5.625 6.25 5 5.625

TAC Control 0.23643 0.31968 0.27806 0.23643 0.31968 0.27806 DOX 0.08658 0.0999 0.09324 0.08658 0.0999 0.09324 ACA+DOX 0.12654 0.10323 0.11489 0.12654 0.10323 0.11489 B.Cereus+DOX 0.1332 0.1665 0.1499 0.1332 0.1665 0.1499

Nitric Oxide Control 4.55 6.7 5.75 4.55 6.7 5.75 DOX 18.25 20.5 19.25 18.25 20.5 19.25 ACA+DOX 20.5 14.5 17 20.5 14.5 17 B.Cereus+DOX 8.25 11.2 5.9 8.25 11.2 5.9

Testosterone Control 2.9 3.1 3 2.9 3.1 3 DOX 0.13 0.15 0.14 0.13 0.15 0.14 ACA+DOX 0.75 0.69 0.72 0.75 0.69 0.72 B.Cereus+DOX 1.3 1.8 1.55 1.3 1.8 1.55

Nrf2 Control 1 1 1 1 1 1 DOX 0.2 0.31 0.25 0.2 0.31 0.25 ACA+DOX 0.6 0.4 0.55 0.6 0.4 0.55 B.Cereus+DOX 0.9 0.8 1.2 0.9 0.8 1.2

NFKB Control 1 1 1 1 1 1 DOX 4.1 5.1 4.6 4.1 5.1 4.6 ACA+DOX 3.2 3.5 4 3.2 3.5 4 B.Cereus+DOX 1.8 2.8 2.9 1.8 2.8 2.9

TLR4 Control 1 1 1 1 1 1 DOX 3 2.6 3.6 3 2.6 3.6 ACA+DOX 2 1.5 2.9 2 1.5 2.9 B.Cereus+DOX 0.5 1 1.6 0.5 1 1.6

mir-34c Control 1 1 1 1 1 1 DOX 0.2 0.17 0.18 0.2 0.17 0.18 ACA+DOX 0.7 0.65 0.67 0.7 0.65 0.67 B.Cereus+DOX 2.1 2.4 2.25 2.1 2.4 2.25

miR-155 Control 1 1 1 1 1 1 DOX 2.8 2.1 2.45 2.8 2.1 2.45 ACA+DOX 1.3 1.5 1.4 1.3 1.5 1.4 B.Cereus+DOX 1.1 1 1.1 1 1 1.1

Bax Control 1 1 1 1 1 1 DOX 2.3 2.4 2.35 2.3 2.4 2.35 ACA+DOX 1.9 1.9 1.9 1.9 1.9 1.9 B.Cereus+DOX 1.5 1.6 1.55 1.5 1.6 1.55

Bcl2 Control 1 1 1 1 1 1 DOX 0.3 0.34 0.32 0.3 0.34 0.32 ACA+DOX 0.7 0.67 0.685 0.7 0.67 0.685 B.Cereus+DOX 1.5 1.6 1.55 1.5 1.6 1.55

Bax/Bcl2 Control 1 1 1 1 1 1 DOX 7.7 7.1 7.3 7.7 7.1 7.3 ACA+DOX 2.7 2.8 2.8 2.7 2.8 2.8 B.Cereus+DOX 1.01 1 1 1.01 1 1

miR-34C+miR-155 Control DOX ACA+DOX B.Cereus+DOX miR-34c 1 0.2 0.7 2.1 1 0.17 0.65 2.4 1 0.18 0.67 2.25 1 0.2 0.7 2.1 1 0.17 0.65 2.4 1 0.18 0.67 2.25 miR-155 1 2.8 1.3 1.1 1 2.1 1 1 1 2.45 1.4 1.1 1 2.8 1.3 1 1 2.1 1 1 1 2.45 1.4 1.1

MDA Control 17.3 11.2 17.6 17.3 11.2 17.6 DOX 54.3 62.5 46.3 54.3 62.5 46.3 ACA+DOX 43.2 38.8 39.7 43.2 38.8 39.7 B.Cereus+DOX 25.1 20.3 19.1 25.1 20.3 19.1

GSH Control 17.9 23.3 25.4 17.9 23.3 25.4 DOX 11.5 11.7 10.2 11.5 11.7 10.2 ACA+DOX 13.2 14.2 14.2 13.2 14.2 14.2 B.Cereus protease+DOX 16.5 16.5 15.2 16.5 16.5 15.2

GSH, MDA, NO Control DOX ACA+DOX B.Cereus+DOX GSH (mmol/g tissue) 17.9 11.5 13.2 16.5 23.3 11.7 14.2 16.5 25.4 10.2 14.2 15.2 17.9 11.5 13.2 16.5 23.3 11.7 14.2 16.5 25.4 10.2 14.2 15.2 MDA (nmol/g tissue) 17.3 54.3 43.2 25.1 11.2 62.5 38.8 20.3 17.6 46.3 39.7 19.1 17.3 54.3 43.2 25.1 11.2 62.5 38.8 20.3 17.6 46.3 39.7 19.1 NO (mmol/L) 4.55 18.25 20.5 8.25 6.7 20.5 14.5 11.2 5.75 19.25 17 5.9 4.55 18.25 20.5 8.25 6.7 20.5 14.5 11.2 5.75 19.25 17 5.9

PCNA sh <TextAlign align="Center">Control</TextAlign> 9.8 0.009 <TextAlign align="Center">DOX</TextAlign> 0.713 0.183 ACA+DOX 8.135 1.15 B.Cereus+DOX 9.496 1.36

TNF sh Control 0.088 0.034 DOX 18.27 1.417 ACA+DOX 2.98 0.52 B.Cereus+DOX 0.198 0.068

Caspase-3 sh Control 0.1085 0.082 DOX 7.384 1.845 ACA+DOX 2.374 0.588 B.Cereus+DOX 0.202 0.043

TNF Control 0.098 0.079 0.087 0.098 0.079 0.087 DOXO 22.213 15.514 17.886 17.489 18.276 22.213 ACA+DOX 4.127 3.011 1.462 2.214 4.082 2.979 B.Cereus+DOX 0.276 0.075 0.351 0.09 0.198 0.075

Caspase-3 Control 0.592 0.026 0.191 0.269 0.2695 0.026 DOXO 6.032 5.085 11.035 6.032 5.085 11.035 ACA+DOX 3.464 1.447 2.21 3.464 1.447 2.21 B.Cereus+DOX 0.128 0.2087 0.276 0.204 0.67375 0.2042

PCNA Control 6.061 7.656 5.425 16.564 13.294 9.8 DOXO 0.71 0.127 0.878 0.169 0.551 1.086 ACA+DOX 9.591 11.952 6.845 6.468 5.822 8.136 B.Cereus+DOX 11.17 6.762 9.255 9.377 14.908 5.506