{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Sheet1","Sheet2","Sheet3"],"read":"whole","date_system":"1900","formulas":"cached_only"}

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["Additional file 7. Similarity of sets of regulated target genes for 190 TFs. Numbers - z-values (hypergeometric test); for downregulated genes, z-values are multiplied by (-1)"]
["Headers","LHX4_up","LHX5_up","LHX1_up","LHX3_up","MEF2A_up","MEF2C_up","PPARG_up","PPARA_up","SPIB_up","SPI1_up","IRF1_up","IRF2_up","ESRRA_up","ESRRG_up","ESRRB_up","NKX2-2_up","NKX2-5_up","NKX2-1_up","RUNX1_up","RUNX3_up","NEUROD6_up","NEUROD4_up","NEUROD1_up","NEUROG3_up","NEUROG2_up","NEUROG1_up","NEUROD2_up","MYF5_up","MYOD1_up","ASCL1_up","ASCL2_up","TCF12_up","CEBPD_up","CEBPB_up","CEBPA_up","GATA3_up","GATA2_up","GATA1_up","GATA6_up","CTNNB1_up","EOMES_up","T_up","NANOG_up","SOX2_up","PDX1_up","OTX1_up","OTX2_up","FOXA2_up","FOXA1_up","JUN_up","JUNB_up","FOSL1_up","FOS_up","TFAP2C_up","TP73_up","ZBTB3_up","FOSL2_up","JUND_up","FOXD3_up","HHEX_up","SOX5_up","TFE3_up","TCF4_up","SMAD2_up","SMAD5_up","SMAD4_up","ELK1_up","FLI1_up","ETS1_up","CREB1_up","NFIB_up","NFIA_up","NFIC_up","NR2F2_up","NR2F1_up","E2F1_up","E2F4_up","E2F7_down","E2F6_down","EGR2_up","ZBTB7A_up","KLF15_up","KLF4_up","KLF1_up","KLF2_up","KLF6_up","KLF14_down","KLF9_down","KLF8_down","KLF12_down","PATZ1_down","POLR3A_up","KLF11_up","KLF14_up","KLF9_up","KLF8_up","KLF12_up","MYBL2_up","CHD4_up","E2F7_up","KLF3_up","ELL2_up","FOXM1_up","FOS_down","FOSL1_down","SLBP_down","GTF2B_down","POU2F2_down","CHD1_down","SIRT3_down","STAT5A_down","TCF12_down","SMAD2_down","MYC_up","MXI1_down","MAX_down","UBTF_up","CUX1_up","HEY1_up","ID1_down","CTBP1_down","FOXH1_up","SMAD3_up","TCF7L2_down","SMAD7_down","SMAD7_up","SMAD3_down","JUN_down","DLX3_down","DLX4_down","FOXA2_down","FOXA1_down","OTX1_down","OTX2_down","SOX2_down","T_down","NANOG_down","GATA6_down","GATA1_down","GATA2_down","GATA3_down","NR2F1_down","NR2F2_down","ZBTB45_down","HDAC8_down","HDAC2_down","TP53_down","HDAC3_down","CBX2_down","NEUROD6_down","NEUROG2_down","NEUROG1_down","NEUROD1_down","NEUROD4_down","NEUROD2_down","TEAD4_down","GTF2F1_down","KLF5_down","SMARCA4_down","CRY1_down","SAP30_down","RFX5_down","RUVBL2_down","SMC3_down","SIN3A_down","KLF4_down","KLF1_down","KLF2_down","PBX1_down","BACH1_down","NFE2L1_up","MAFK_down","CTBP2_down","E2F4_down","E2F1_down","ATF3_down","BATF_down","ATF1_down","ATF2_down","SNAI2_down","SNAI1_down","FLI1_down","ELK1_down","GABPA_down","BHLHE40_down","CEBPA_down","HNF1A_down","ZBTB3_down","GLIS2_down","PHF8_down"]
["LHX4_up",1000,23.4098,26.11,42.5419,0,0,0,0,0,0,0,0,0,0,6.4439,0,0,0,0,0,0,0,0,0.7731,0.5753,2.1603,3.4588,0,0,0.6687,0,0,0,3.5696,3.4219,4.1811,3.5031,4.8628,2.7246,7.9566,3.8007,0,8.2308,0,9.6648,3.7131,5.5548,3.8156,2.2615,1.8247,4.5948,5.2022,5.2016,2.585,2.4321,0,0,0,7.8587,0,0,3.6365,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.0354,2.6347,0,0,0,0,0,0,0,0,-0.0545,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,6.3453,0,-7.7986,6.1674,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7.8274,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-10.0934,-3.1829,0,0,0,0,0,0,0,0,0,0]
["LHX5_up",23.4098,1000,59.6884,45.9939,0,0,0,0,0.8394,0,0,0,0,0,0,0,4.8607,0,0,0,0,4.9169,2.6339,3.7045,4.1322,5.075,4.0164,2.015,0.9151,1.6506,3.6487,5.1455,0,2.6618,3.2378,4.8682,7.1861,7.0964,8.3814,8.4794,7.6725,6.3336,10.4044,8.1047,15.0536,8.2193,10.6262,3.766,3.8607,4.5552,4.6646,7.9649,4.6855,3.9237,3.6465,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,5.2962,0,0,0,0,0,0,4.9012,2.961,0.2179,0,0,1.3177,0,-0.3547,-0.0786,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6.4288,14.5734,11.1094,-8.4131,-9.4586,8.3788,0,0,0,0,0,0,-4.492,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-6.2275,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1.4746,0,0,0,0,0,0,0,0,0,0]
["LHX1_up",26.11,59.6884,1000,36.0087,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4.6699,2.7963,2.9418,3.8519,3.3309,2.8927,0,0,1.5307,0,0,0,0,0.9018,4.9284,5.6907,4.658,3.244,6.8042,7.9959,0,7.429,0,19.9286,4.8871,8.0176,4.3191,3.2138,2.3727,2.6517,6.0779,3.3672,0,1.6377,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,4.3967,1.1438,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-11.7134,7.2434,0,0,0,9.282,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]
["LHX3_up",42.5419,45.9939,36.0087,1000,10.1948,4.3618,0,0,3.5448,1.2761,0,0,0,0,6.1216,10.0788,6.4995,7.0706,0,5.2914,4.795,6.0789,3.5331,4.6467,4.7275,6.9012,5.1706,6.8449,4.8383,2.261,4.252,5.7467,2.6083,6.2721,8.459,12.4988,11.1849,10.6372,10.7913,14.2606,14.5547,7.6921,15.9599,9.3754,21.3452,7.6873,12.6189,5.6608,6.3035,10.7738,12.086,15.5907,13.4671,6.6795,8.1359,4.1606,10.3926,0,5.2521,6.7413,4.1722,2.9194,0,0,0,0,0,5.2746,0,5.059,0,0,10.4275,9.2199,7.9281,0.1972,0.7972,-1.05,-0.8266,5.4971,4.098,0,0,0,0,2.3241,0,0,0,0,0,0,5.8991,0,0,0,0,0,0,0,0,0,5.8568,0,0,0,0,0,0,0,0,0,0,2.7098,0,-0.7907,10.5071,0,9.3737,0,-11.5613,11.4226,14.9567,-15.0243,-12.1442,9.7084,-5.04,0,0,0,-8.4711,-11.0726,-7.4681,-4.8995,-5.7985,-4.3326,-3.4131,-7.3461,-10.0788,-8.2764,0,0,0,0,0,0,0,0,0,-10.389,0,0,0,-8.7952,-5.8434,-12.0718,0,0,-9.7335,-7.2374,0,0,0,-9.7027,0,0,-4.8547,0,-10.0641,0,0,-8.0369,-4.5802,0,0,0,0,0,-7.5835,-3.8121,0,0,0,0,-2.3969,0,0,0,0,0]
["MEF2A_up",0,0,0,10.1948,1000,28.7154,0,0,7.1855,5.7808,6.0805,3.7486,0,0,0,0,6.4286,4.9006,5.6146,9.5057,2.4275,3.1628,2.6805,2.8753,3.7168,4.1648,2.8216,7.2829,12.3608,2.0496,3.1167,2.9987,3.1694,3.9059,4.2126,7.066,6.1877,8.4959,6.2081,6.4283,4.2224,5.9129,6.3067,5.4189,8.5547,1.5448,3.2365,5.3606,4.9837,7.6585,8.5934,9.2719,4.9915,5.58,6.685,2.7672,5.9199,0,5.0295,0,0,1.7368,0,0,0,0,0,8.8882,4.9817,2.1917,5.9401,0,8.8169,0,0,2.9649,3.8765,0,-2.399,4.5649,5.0286,1.1151,0.8944,0.4512,1.606,0.2858,-1.1525,-0.0898,0,0,-1.1317,0,5.3259,0,0,0,0,0,0,0,0,0,3.1269,0,0,0,0,0,0,0,0,0,0,0.2702,0,0,0,0,0,0,0,3.649,7.4698,0,-4.9861,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-7.2884,0,0,-7.8473,0,0,0,0,-10.6201,0,-0.9853,0,0,0,0,0,0,0,0,0,0,0,-6.6376,-8.4299,-3.1234,0,0,0,0,-1.4628,0,0,-3.9646,0,0]
["MEF2C_up",0,0,0,4.3618,28.7154,1000,0,0,9.5595,7.8636,2.4873,0,0,0,3.8876,4.4733,8.2866,3.6164,6.9377,10.2713,0,3.1223,2.4697,4.8164,4.7497,5.3086,6.2992,9.0008,11.1743,2.0142,0.3887,0.305,1.4027,6.8375,8.5483,5.8515,2.0111,4.5741,3.582,3.4818,0.5322,0,5.1816,9.4251,4.9089,2.9808,4.1972,6.8091,7.6702,5.8807,7.9451,4.5935,4.0969,3.5852,5.3267,3.6509,3.0401,0,4.3983,0,4.4997,1.2005,0,0,0,0,0,7.7091,8.7376,7.8862,5.4613,0,11.2525,0,0,0.9561,0,0,0,4.4406,6.3601,2.9427,3.2634,1.7555,2.2837,1.1115,0,-0.0186,0,-0.4716,-1.1765,13.146,12.1331,12.697,15.3155,10.5885,15.8341,18.2274,16.6722,19.7983,0,15.3053,9.1809,-6.8094,-4.6994,-14.6052,0,0,-11.9206,0,-15.6981,0,0,0,0,0,7.6065,0,0,0,0,2.4993,2.3112,0,-0.4209,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-1.9268,-1.2152,0,0,0,0,0,0,0,0,0,0,0,0,-4.8266,0,0,0,0,0,0,0,0,0,-0.0756,-3.2909,0,0,0,0,0,0,0,0,-4.8631,0,-5.1791,-10.4034,-0.9337,0,0,0,0,-0.7895,0,0,0,0,0]
["PPARG_up",0,0,0,0,0,0,1000,41.4182,2.658,1.1946,0,0,0,6.8932,9.3817,5.1197,8.6622,6.9246,2.8788,0,1.9314,4.4627,3.6258,3.6875,2.3409,3.6965,5.2838,0.1082,3.5453,1.5035,1.9374,2.3712,5.0359,9.2599,3.8663,7.1644,5.766,6.4253,4.6934,0,2.015,2.7282,4.1482,3.9144,0,6.1035,6.4049,6.2398,4.8841,5.6568,5.2179,6.7951,5.2454,3.0171,3.5569,1.6371,4.387,0,5.9308,8.7631,13.5308,7.0534,0,0,0,0,0,0,2.8329,3.0135,0,0,3.6709,0,11.4655,0.0924,0,0,0,3.6498,3.1636,5.0756,1.9862,3.3773,3.6581,0.9956,-1.0791,-2.617,-0.5468,-2.5541,-1.728,0,4.6637,6.1038,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.1722,0,-0.7175,0,0,0,0,0,2.3188,1.7607,-5.1586,-4.1815,4.8717,0,0,0,0,0,0,-2.9491,0,0,-3.0216,0,0,0,0,0,-8.0524,-8.862,0,0,0,0,0,0,0,0,0,0,0,0,-4.4626,0,0,0,0,0,0,0,0,0,-0.5279,-3.8925,0,0,0,4.7285,0,-5.5626,0,0,0,0,0,-5.7057,-1.5595,0,0,0,0,-4.1194,0,0,0,0,0]
["PPARA_up",0,0,0,0,0,0,41.4182,1000,1.7128,1.0586,0,0,0,8.8366,7.7313,0,3.1257,0,2.0944,2.6157,1.8014,1.4063,0.0775,1.4246,1.5249,0.7886,1.964,1.8117,3.3012,2.1571,1.7861,1.6831,3.8086,6.826,5.1199,4.188,5.0043,3.7996,5.3356,1.9214,2.3027,0,2.0858,3.0066,0,2.2056,4.5538,4.0855,4.2176,0,2.0229,0,2.3646,3.5424,1.4622,0.5469,0,0,4.9286,8.4846,11.246,5.2165,0,0,0,0,0,0,3.3758,1.4314,0,0,0,0,8.7289,0,0,0,0,1.2137,0.2715,0.5936,1.4142,1.4195,2.5087,0.4366,0,0,0,0,-1.0641,0,6.6651,3.9145,7.8819,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.8102,0,-0.5951,0,0,0,0,-4.4855,0,0,0,-1.2892,3.1668,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,-3.4444,-6.8993,0,0,0,0,0,0,0,0,0,0,0,0,-3.0609,0,0,0,0,0,0,0,0,0,-1.4032,0,0,0,0,4.5573,0,0,0,0,0,0,0,0,-1.3177,0,0,0,0,-2.1062,0,0,0,0,0]
["SPIB_up",0,0.8394,0,3.5448,7.1855,9.5595,2.658,1.7128,1000,76.2259,13.2009,12.9791,0,1.1774,6.6773,3.8464,6.8711,3.4826,16.7715,17.1676,0,4.5076,2.7241,2.7674,3.4065,3.6483,2.9681,6.6434,5.1623,2.255,1.1937,4.191,8.5786,12.0857,9.9303,12.6643,4.9808,7.0651,5.1575,3.7511,4.9807,6.8701,5.4953,2.9186,2.3729,3.6906,5.4,7.1115,4.6649,14.1733,15.6553,11.4705,11.9172,8.4652,9.8294,5.4316,6.0332,1.4015,8.3663,5.3997,8.8533,6.7491,0.9644,0,0,0,7.9884,10.9028,18.8177,5.6476,6.4744,2.7267,3.5241,2.0936,5.4785,0.5584,0,0,0,6.6307,6.7573,5.4968,6.6294,2.8032,7.6709,5.0658,0,-1.0026,0,-1.4755,0,0,2.8441,1.3437,0.1397,0,0,1.9985,1.0119,0,0,0,1.5612,0,-1.3806,0,0,0,0,0,0,0,0,0,0,-1.2687,5.8824,5.9413,0,0,-3.0563,2.1797,4.4561,-0.7546,-3.1311,0,0,-0.1788,0,0,0,-0.8058,0,0,0,0,0,-1.3205,-1.1693,-2.9949,-0.6806,-3.3535,-2.9165,0,-2.9005,-3.9422,-4.9922,0,0,-4.5346,0,0,-2.0246,-3.2552,-2.1771,-4.6675,0,0,-6.9643,-3.3751,-3.8308,-1.6874,0,-5.3316,-3.3081,0,-0.0959,0,-3.2795,-3.5268,1.6614,-0.6806,0,0,-1.2591,-1.5312,-3.3872,-2.3135,-4.058,-0.5162,-0.4043,0,0,0,-1.3966,0,0,0,0,-1.5793]
["SPI1_up",0,0,0,1.2761,5.7808,7.8636,1.1946,1.0586,76.2259,1000,11.8801,12.5897,0,1.8109,5.0714,4.7207,4.3986,4.4889,11.5725,13.4051,0,3.485,1.9477,3.3924,3.6793,2.9398,3.0149,6.4285,3.9347,2.6674,1.8962,4.3034,5.2157,7.7914,7.0964,10.0253,2.488,3.4825,2.6042,2.4295,3.4977,6.0712,4.7388,4.6057,1.0212,3.0801,2.8269,4.0132,1.4637,9.8487,11.7968,9.4757,7.9968,8.4331,8.9722,3.43,5.7731,0,6.9232,4.5029,5.61,3.2904,0.7779,0,0,0,6.2508,11.6881,19.2065,6.8715,5.2471,0,1.0963,0,5.6094,0,0,0,0,6.6229,6.5378,6.6008,7.8835,3.1902,7.2034,5.6702,-0.7598,-2.4673,0,-3.4817,0,0,1.2178,0.7779,0,0,0,0,0,0,0,0,0.3993,0,-3.6889,0,0,0,0,0,0,0,0,0,0,-0.5139,0,6.3782,0,0,-1.5107,2.8592,2.2399,0,-1.9606,0,-2.0309,-0.4781,0,0,-1.3625,-1.7219,0,0,0,0,0,-2.0697,-1.545,-3.367,0,-2.852,-3.0746,0,0,0,-5.4867,0,0,-3.6997,0,0,0,0,0,-3.6388,0,0,-4.6845,0,0,0,0,0,-4.4584,0,-1.3072,0,0,0,1.2649,0,0,0,0,-3.1861,0,-3.4831,-4.1419,-1.2647,-0.1567,0,0,0,-0.7163,0,0,-0.4323,0,-2.1495]
["IRF1_up",0,0,0,0,6.0805,2.4873,0,0,13.2009,11.8801,1000,64.0068,0,0,2.5287,0,1.0681,0,1.6509,3.6839,0,0,0,0,0,0.2606,0,0.4735,0.6368,0,0,0,0.9985,1.0897,2.5264,2.1218,2.31,2.571,0.9603,2.2165,1.9103,1.8579,4.9777,3.779,2.1373,0.7596,1.0799,0.963,0.5478,2.8564,3.5875,2.6799,2.1436,0,3.9525,0.252,4.035,0,2.4546,0,2.5073,0.9104,0,0,0,0,0,4.4963,2.8318,1.6177,0,0,1.3712,0,0,1.092,0.2958,0,0,0,0,0,0.6382,0.3092,0.3756,1.852,0,0,0,0,0,0,5.4169,3.1864,0,0,0,0,4.1402,0,0,0,1.7277,0,0,0,0,0,0,0,0,0,0,0.6259,0,0,0,0,0,0,-2.8307,1.9944,0.2468,-4.2279,-0.3356,0,0,-2.8102,0,0,0,0,0,0,0,0,0,0,-3.3013,0,0,0,-1.3761,0,0,0,0,0,0,0,0,0,0,0,0,-1.8523,0,0,-3.758,0,0,0,0,0,0,0,-1.5411,0,0,0,0,-4.3841,0,0,0,0,0,0,-2.2522,-1.5266,-2.4176,0,0,0,-1.3414,0,0,0,0,0]
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["NKX2-2_up",0,0,0,10.0788,0,4.4733,5.1197,0,3.8464,4.7207,0,0,0,9.9883,15.1467,1000,36.8563,49.7666,8.7012,9.6114,0,6.0853,5.2525,5.3936,6.044,6.9417,7.726,10.0018,9.8731,5.0196,10.2971,15.2376,2.5687,6.9879,4.6271,17.1333,10.821,13.5227,9.6586,12.3272,13.473,11.4812,11.7646,7.9475,12.9719,8.201,6.346,13.1354,9.3381,10.7085,14.6663,12.3112,9.9494,13.0394,6.7497,8.553,8.4352,0,14.3743,10.9096,8.542,7.3175,10.174,0,0,0,0,0,4.8113,3.8883,7.8855,0,14.7595,0,11.16,4.5648,0,0,0,8.9308,5.7392,5.9048,6.4109,6.5963,7.9634,5.1053,-1.6212,-3.1821,-0.7472,-4.5492,0,0,7.3028,7.7289,0,0,0,0,0,0,0,0,3.6229,0,0,0,0,0,0,0,0,0,0,0,0,0,0,16.2387,0,0,-10.6187,5.9879,0,0,-5.7442,7.2972,-7.6707,0,0,0,0,0,0,0,0,-4.2926,0,0,0,0,0,-2.4322,-4.2589,0,0,0,0,0,0,-10.6706,0,0,0,0,0,-6.7463,0,0,0,0,0,0,0,0,-8.7088,0,0,0,0,0,0,0,0,0,0,0,0,-7.3685,-6.2808,-6.1564,-5.4626,0,0,0,-1.9635,0,0,0,0,0]
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["E2F7_down, 403",null,"E2F7_down",403,null,"Headers","E2F3_up, 116",{"$nulls":3},"ASCL1_up, 1487",168]
["E2F6_down, 444",null,"E2F6_down",444,null,"SNAI2_down, 1588",1.435,1,null,null,"ASCL2_up, 428",167]
["E2F1_up, 1202",null,"E2F1_up",1202,null,"SNAI1_down, 942",2.4762,2,null,null,"ATF1_down, 72",223]
["E2F4_up, 557",null,"E2F4_up",557,null,"SNAI3_down, 777",3.6632,3,null,null,"ATF2_down, 170",225]
["EGR2_up, 1922",null,"EGR2_up",1922,null,"TBX3_down, 21",0,4,null,null,"ATF3_down, 78",224]
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