Table S4 Toxicity and treatment effect of FTY720 alone or in combination from included articles
Author year	Toxicity	Combination	Therapeutic evaluation	Cancer types	
Yang Li
2018, China	no change in body temperature and general toxicity	FTY720 + cisplatin	improved	non-small lung cancer	
Manendra Babu Lankadasari
2018, India	NA	FTY720 + gemcetabine	improved	pancreatic cancer	
Kelly M. Kreitzburg
2018, USA	NA	FTY720 + tamoxifen
FTY720 + carboplatin	improved	ovarian cancer	
Agata Szymiczek
2017, USA	no obvious toxicity;
tumor weight data	NA	NA	mesothelioma	
Yuki Muroyama
2017, USA	NA	FTY720 + radiotherapy	improved	melanoma	
Janet L. Martin
2017, Australia	no obvious toxicity,
potentially offering a treatment with lower toxicity than standard chemotherapy	FTY720 + gefitinib
	improved	triple negative breast cancer	
Veronica Lifshitz
2017, USA	no obvious toxicity	FTY720 + etoposide	improved	neuroblastoma	
Eriko Katsuta
2017, USA	lower toxicity than standard chemotherapy	FTY720 + doxorubicin	improved	breast cancer	
Heba Alshaker
2017, UK	no weight loss, liver toxicity and, lymphopenia
tumor weight data	docetaxel + FTY720 + nanoparticle	improved	triple negative breast cancer	
Masayuki Nagahashi
2016, US	NA	NA	NA	breast cancer	
Cecil Gstealder
2016, France	no obvious toxicity
	FTY720 + gemcitabine	improved	renal cell carcinoma	
Wohn-Jenn Leu
2016, China, Taiwan	tumor weight data	NA	NA	prostate cancer	
NC Hait
2015, USA	no obvious toxicity	FTY720 + tamoxifen	improved	breast cancer	
Seon Min Woo
2015, South Korea	NA	FTY720 + TRAIL	improved	Renal cell carcinoma	
Hao Liu
2015, China	NA	NA	NA	non-small cell lung cancer	
Yunze Xu
2015, China	Tumor weight data;
no toxicity in vital organs	NA	NA	adrenocortical carcinoma	
Hao Liu
2014, China	NA	FTY720 + cisplatin	improved	non-small cell lung cancer	
Limin Chen
2014, China	NA	NA	NA	acute myelogenous leukemia	
Roberta Rosa
2013, Italy	no toxicity in weight loss	FTY720 + cetuximab	improved	colorectal cancer	
Mei-Hong Li
2013, USA	NA	FTY720 + topotecan	improved	neuroblastoma	
Adriana Estrada-Bernal
2012, USA	NA	FTY720 + temozolomide	improved	glioblastoma	
Dmitri Pchejetski
2010, France	no obvious toxicity and weight loss and i.p. inflammation	FTY720 + radiotherapy	improved	prostate cancer	
Gerald Schmid
2007, Germany	NA	NA	NA	lung cancer	
Terence K. Lee
2005, China	no toxicity to infection, diarrhea, or loss of body weight; tumor weight data	NA	NA	hepatocellular carcinoma	
Joanna W.Y. Ho
2005, China	no obvious toxicity;
tumor weight data	NA	NA	hepatocellular carcinoma	
Chee-Wai Chua
2005, China	no obvious toxicity in vital organs such as livers, lungs and kidneys; tumor weight data
	NA	NA	androgen-independent prostate cancer	
Haruhito Azuma
2002, Japan	NA	NA	NA	breast cancer	
Terence K.Lee
2004, China	no obvious toxicity to normal liver cells	NA	NA	hepatocellular cancer	
Yoanne Mousseau
2012, France	NA	FTY720 + sunitinib	improved	breast cancer	
Y Li
2017, China	NA	NA	NA	colon carcinoma ,
lung adeno carcinoma,
melanoma	
Ela Markovsky
2019, USA	NA	FTY720 + radiotherapy	improved (only FTY720 showed negative effect)	breast cancer