{"text_format":"3","workbook":"xls","n_sheets":3,"sheets":["Sheet1","Sheet2","Sheet3"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":41,"n_cols":12,"rows_kept":41,"merged":[[0,1,0,11],[20,0,20,11]],"flags":["formulas_cached_only"]}
[null,"Supplementary Tables S1--Transcriptome analysis of tumor tissue"]
["gene_name","transcript_id","Description","FPKM.Z_1","FPKM.Z_2","FPKM.Z_3","FPKM.M_1","FPKM.M_2","FPKM.M_3","fc","log2(fc)","regulation"]
["Mki67","ENSMUST00000033310;ENSMUST00000211238","antigen identified by monoclonal antibody Ki 67 [Source:MGI Symbol;Acc:MGI:106035]",{"v":3.277904,"d":"3.28"},{"v":21.8718593657688,"d":"21.87"},{"v":5.653124,"d":"5.65"},{"v":1.683442,"d":"1.68"},{"v":4.353677,"d":"4.35"},{"v":26.399548,"d":"26.40"},{"v":0.949631704323037,"d":"0.95"},{"v":-0.0745599934099851,"d":"-0.07"},"down"]
["Kdr","ENSMUST00000113516;ENSMUST00000202473;ENSMUST00000149573","kinase insert domain protein receptor [Source:MGI Symbol;Acc:MGI:96683]",{"v":1.39948451063123,"d":"1.40"},{"v":2.63720244031008,"d":"2.64"},{"v":1.76235417607973,"d":"1.76"},{"v":3.11597676533776,"d":"3.12"},{"v":1.68243830520487,"d":"1.68"},{"v":1.16165340885936,"d":"1.16"},{"v":0.9729822982844137,"d":"0.97"},-0.039514536961758,"down"]
["Casp3","ENSMUST00000209668;ENSMUST00000093517;ENSMUST00000211115;ENSMUST00000210534","caspase 3 [Source:MGI Symbol;Acc:MGI:107739]",26.3483246228776,101.96569678731,33.1656008173965,16.9305240554066,37.6573159553173,91.4485889365505,1.10574891067684,0.145023820973262,"up"]
["Bcl2","ENSMUST00000112751;ENSMUST00000189999","B cell leukemia/lymphoma 2 [Source:MGI Symbol;Acc:MGI:88138]",{"v":1.29416737872666,"d":"1.29"},{"v":2.283487036038,"d":"2.28"},{"v":1.61980101812821,"d":"1.62"},{"v":0.904309377306978,"d":"0.90"},{"v":2.36825869706236,"d":"2.37"},{"v":5.1673441906738,"d":"5.17"},{"v":0.6158186566014388,"d":"0.62"},-0.699422519517207,"down"]
["Cdh1","ENSMUST00000000312;ENSMUST00000167688;ENSMUST00000136580","cadherin 1 [Source:MGI Symbol;Acc:MGI:88354]",{"v":38.5234151580673,"d":"38.52"},{"v":86.6948135408832,"d":"86.69"},{"v":128.309188508089,"d":"128.31"},{"v":15.809505327066,"d":"15.81"},{"v":40.0385513878443,"d":"40.04"},{"v":58.0902542986445,"d":"58.09"},{"v":2.22512879953854,"d":"2.23"},{"v":1.15388884757452,"d":"1.15"},"up"]
["Cdh2","ENSMUST00000025166;ENSMUST00000152779;ENSMUST00000115850","cadherin 2 [Source:MGI Symbol;Acc:MGI:88355]",{"v":0.0537799877262584,"d":"0.05"},{"v":0.0300769153235805,"d":"0.03"},{"v":0.185687560872799,"d":"0.19"},{"v":0.0214410525663278,"d":"0.02"},{"v":0.214653095958344,"d":"0.21"},{"v":0.139381251797669,"d":"0.14"},{"v":0.717875162237626,"d":"0.72"},{"v":-0.478195112231284,"d":"-0.48"},"down"]
["Vim","ENSMUST00000155605;ENSMUST00000028062;ENSMUST00000141365;ENSMUST00000191615;ENSMUST00000148248;ENSMUST00000193675","vimentin [Source:MGI Symbol;Acc:MGI:98932]",{"v":573.174997156019,"d":"573.17"},{"v":455.76031330993,"d":"455.76"},{"v":788.036972200928,"d":"788.04"},{"v":492.707376684588,"d":"492.71"},{"v":430.554875112376,"d":"430.55"},{"v":416.562603098039,"d":"416.56"},{"v":1.35612671762927,"d":"1.36"},{"v":0.439491991419603,"d":"0.44"},"up"]
["Snai1","ENSMUST00000052631","snail family zinc finger 1 [Source:MGI Symbol;Acc:MGI:98330]",{"v":32.492756,"d":"32.49"},{"v":15.039199,"d":"15.04"},{"v":38.656174,"d":"38.66"},{"v":42.351059,"d":"42.35"},{"v":41.778324,"d":"41.78"},{"v":16.99189,"d":"16.99"},{"v":0.852324406556868,"d":"0.85"},{"v":-0.230525450055845,"d":"-0.23"},"down"]
["Mmp9","ENSMUST00000017881;ENSMUST00000137626;ENSMUST00000134382;ENSMUST00000144917","matrix metallopeptidase 9 [Source:MGI Symbol;Acc:MGI:97011]",{"v":147.79051666629,"d":"147.79"},{"v":62.3347331918621,"d":"62.33"},{"v":242.805014684657,"d":"242.81"},{"v":66.2459249208816,"d":"66.25"},{"v":130.251330380051,"d":"130.25"},{"v":81.7070739658096,"d":"81.71"},{"v":1.62804894422955,"d":"1.63"},{"v":0.703144072169169,"d":"0.70"},"up"]
["Twist1","ENSMUST00000049089","twist basic helix-loop-helix transcription factor 1 [Source:MGI Symbol;Acc:MGI:98872]",{"v":18.839233,"d":"18.84"},{"v":13.672353,"d":"13.67"},{"v":21.342039,"d":"21.34"},{"v":23.3971,"d":"23.40"},{"v":22.269709,"d":"22.27"},{"v":13.320055,"d":"13.32"},{"v":0.912976573902962,"d":"0.91"},{"v":-0.131350252364191,"d":"-0.13"},"down"]
["Tgfb1","ENSMUST00000206348;ENSMUST00000002678;ENSMUST00000169009;ENSMUST00000206584;ENSMUST00000171757","transforming growth factor, beta 1 [Source:MGI Symbol;Acc:MGI:98725]",{"v":68.5494882316541,"d":"68.55"},{"v":30.0748706973423,"d":"30.07"},{"v":53.9542669605315,"d":"53.95"},{"v":88.802767393098,"d":"88.80"},{"v":64.7826808193177,"d":"64.78"},{"v":31.50443951309,"d":"31.50"},{"v":0.824348794872073,"d":"0.82"},{"v":-0.278673201459047,"d":"-0.28"},"down"]
["Cldn1","ENSMUST00000023154;ENSMUST00000232215","claudin 1 [Source:MGI Symbol;Acc:MGI:1276109]",{"v":0.0326271683536459,"d":"0.03"},{"v":0.842935080561867,"d":"0.84"},{"v":0.0313396591613303,"d":"0.03"},{"v":0.0359804152034704,"d":"0.04"},{"v":0.0001,"d":"0.00"},{"v":0.067332398884528,"d":"0.07"},{"v":8.76972468136416,"d":"8.77"},{"v":3.1325315511004,"d":"3.13"},"up"]
["Fn1","ENSMUST00000187627;ENSMUST00000189160;ENSMUST00000188092;ENSMUST00000190780;ENSMUST00000186879;ENSMUST00000188894;ENSMUST00000189821;ENSMUST00000055226;ENSMUST00000185408;ENSMUST00000186940;ENSMUST00000187938;ENSMUST00000186575;ENSMUST00000186129;ENSMUST00000188674;ENSMUST00000186613;ENSMUST00000186736;ENSMUST00000186985","fibronectin 1 [Source:MGI Symbol;Acc:MGI:95566]",{"v":766.864410689602,"d":"766.86"},{"v":780.385180869576,"d":"780.39"},{"v":900.766634626358,"d":"900.77"},{"v":1121.86325374506,"d":"1121.86"},{"v":711.741622950706,"d":"711.74"},{"v":488.900333837056,"d":"488.90"},{"v":1.05404122026659,"d":"1.05"},{"v":0.0759312873844001,"d":"0.08"},"up"]
["Mmp3","ENSMUST00000034497","matrix metallopeptidase 3 [Source:MGI Symbol;Acc:MGI:97010]",{"v":24.1619,"d":"24.16"},{"v":68.046783,"d":"68.05"},{"v":31.244776,"d":"31.24"},{"v":28.711962,"d":"28.71"},{"v":112.154335,"d":"112.15"},{"v":106.963554,"d":"106.96"},{"v":0.498137970473944,"d":"0.50"},{"v":-1.00538271052489,"d":"-1.01"},"down"]
["Rdx","ENSMUST00000000590;ENSMUST00000163153;ENSMUST00000238858;ENSMUST00000061352","radixin [Source:MGI Symbol;Acc:MGI:97887]",{"v":4.21510222062553,"d":"4.22"},{"v":24.9639209778107,"d":"24.96"},{"v":7.13616836665258,"d":"7.14"},{"v":3.26016351986475,"d":"3.26"},{"v":6.89975605663567,"d":"6.90"},{"v":27.5888756037616,"d":"27.59"},{"v":0.962022533213913,"d":"0.96"},{"v":-0.0558574086100862,"d":"-0.06"},"down"]
[]
[]
[]
["Supplementary Tables S2--Transcriptome analysis of lung tissue"]
["gene_name","transcript_id","Description","FPKM.Lung_Z_1","FPKM.Lung_Z_2","FPKM.Lung_Z_3","FPKM.Lung_M_1","FPKM.Lung_M_2","FPKM.Lung_M_3","fc","log2(fc)","regulation"]
["Mki67","ENSMUST00000033310;ENSMUST00000211238","antigen identified by monoclonal antibody Ki 67 [Source:MGI Symbol;Acc:MGI:106035]",{"v":2.285641,"d":"2.29"},{"v":2.40937630931319,"d":"2.41"},{"v":1.992898,"d":"1.99"},{"v":1.722061,"d":"1.72"},{"v":2.453244,"d":"2.45"},{"v":2.560828,"d":"2.56"},{"v":0.992841933096213,"d":"0.99"},{"v":-0.010364045301057,"d":"-0.01"},"down"]
["Kdr","ENSMUST00000113516;ENSMUST00000202473;ENSMUST00000149573","kinase insert domain protein receptor [Source:MGI Symbol;Acc:MGI:96683]",{"v":19.7551879957918,"d":"19.76"},{"v":30.5642610118494,"d":"30.56"},{"v":27.3546667834994,"d":"27.35"},{"v":33.1020643998893,"d":"33.10"},{"v":31.7062783362126,"d":"31.71"},{"v":35.9498908976744,"d":"35.95"},{"v":0.770895965420166,"d":"0.77"},{"v":-0.375391917366376,"d":"-0.38"},"down"]
["Egfr","ENSMUST00000102884;ENSMUST00000020329;ENSMUST00000138518;ENSMUST00000139722;ENSMUST00000125984","epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294]",{"v":1.12896370121844,"d":"1.13"},{"v":1.18297700026488,"d":"1.18"},{"v":1.241617840279,"d":"1.24"},{"v":1.67387090120078,"d":"1.67"},{"v":1.22078598861028,"d":"1.22"},{"v":1.40516895320501,"d":"1.41"},{"v":0.826442435461459,"d":"0.83"},{"v":-0.275013760507715,"d":"-0.28"},"down"]
["Bax","ENSMUST00000210392;ENSMUST00000211365;ENSMUST00000033093;ENSMUST00000211615;ENSMUST00000211195;ENSMUST00000210019","BCL2-associated X protein [Source:MGI Symbol;Acc:MGI:99702]",{"v":26.648809518401,"d":"26.65"},{"v":28.3811347887056,"d":"28.38"},{"v":36.4612992848985,"d":"36.46"},{"v":27.8380108864213,"d":"27.84"},{"v":27.537072875,"d":"27.54"},{"v":27.1680365203046,"d":"27.17"},{"v":1.10840544045026,"d":"1.11"},{"v":0.148485697212504,"d":"0.15"},"up"]
["Bcl2","ENSMUST00000189999;ENSMUST00000112751","B cell leukemia/lymphoma 2 [Source:MGI Symbol;Acc:MGI:88138]",{"v":1.59367455509446,"d":"1.59"},{"v":1.0505016241127,"d":"1.05"},{"v":0.953029414655455,"d":"0.95"},{"v":1.15922330839795,"d":"1.16"},{"v":1.42438934651087,"d":"1.42"},{"v":1.27004058261439,"d":"1.27"},{"v":0.933453368049945,"d":"0.93"},{"v":-0.0993501424556903,"d":"-0.10"},"down"]
["Casp3","ENSMUST00000211115;ENSMUST00000210534;ENSMUST00000209668;ENSMUST00000093517","caspase 3 [Source:MGI Symbol;Acc:MGI:107739]",{"v":9.05061135358951,"d":"9.05"},{"v":8.2264091590706,"d":"8.23"},{"v":5.27123217753947,"d":"5.27"},{"v":7.0927962266905,"d":"7.09"},{"v":8.5117389025916,"d":"8.51"},{"v":6.53481923324397,"d":"6.53"},{"v":1.01846929774816,"d":"1.02"},{"v":0.0264024902163198,"d":"0.03"},"up"]
["Cdh1","ENSMUST00000000312;ENSMUST00000167688;ENSMUST00000136580","cadherin 1 [Source:MGI Symbol;Acc:MGI:88354]",{"v":62.7979339599913,"d":"62.80"},{"v":41.8364984494972,"d":"41.84"},{"v":55.8822085863577,"d":"55.88"},{"v":54.0412930065588,"d":"54.04"},{"v":48.8283050546568,"d":"48.83"},{"v":54.8047672470485,"d":"54.80"},{"v":1.01802623833002,"d":"1.02"},{"v":0.0257747455204696,"d":"0.03"},"up"]
["Cdh2","ENSMUST00000025166;ENSMUST00000152779;ENSMUST00000115850","cadherin 2 [Source:MGI Symbol;Acc:MGI:88355]",0.174529724274733,0.409767274733449,0.279385140714109,0.421156873667245,0.493880926233573,0.545025431936524,0.591537490219129,-0.757458488893335,"down"]
["Vim","ENSMUST00000028062;ENSMUST00000141365;ENSMUST00000155605;ENSMUST00000148248;ENSMUST00000193675;ENSMUST00000191615","vimentin [Source:MGI Symbol;Acc:MGI:98932]",{"v":205.489070771874,"d":"205.49"},{"v":188.777579840186,"d":"188.78"},{"v":194.60749646342,"d":"194.61"},{"v":149.776363994518,"d":"149.78"},{"v":165.09095112587,"d":"165.09"},{"v":167.72826425448,"d":"167.73"},{"v":1.22022283718032,"d":"1.22"},{"v":0.287144636917895,"d":"0.29"},"up"]
["Snai1","ENSMUST00000052631","snail family zinc finger 1 [Source:MGI Symbol;Acc:MGI:98330]",11.45423,15.55604,16.635237,17.427475,13.858493,13.676122,0.970717931484057,-0.0428759526589564,"down"]
["Snai2","ENSMUST00000023356","snail family zinc finger 2 [Source:MGI Symbol;Acc:MGI:1096393]",1.599844,1.376912,1.090044,1.420822,1.941867,2.182952,0.733332720239193,-0.447460183118828,"down"]
["Mmp9","ENSMUST00000017881;ENSMUST00000137626;ENSMUST00000134382;ENSMUST00000144917","matrix metallopeptidase 9 [Source:MGI Symbol;Acc:MGI:97011]",{"v":301.563115403504,"d":"301.56"},{"v":452.499448042667,"d":"452.50"},{"v":382.251412669398,"d":"382.25"},{"v":329.83598564425,"d":"329.84"},{"v":388.096476803617,"d":"388.10"},{"v":304.886123093529,"d":"304.89"},{"v":1.11096336357058,"d":"1.11"},{"v":0.151811241509595,"d":"0.15"},"up"]
["Mmp7","ENSMUST00000018767","matrix metallopeptidase 7 [Source:MGI Symbol;Acc:MGI:103189]",0.0001,0.0001,0.0001,0.141958,0.0001,0.0001,0.002110328,-8.888317073,"down"]
["Mmp2","ENSMUST00000034187;ENSMUST00000211567;ENSMUST00000211691;ENSMUST00000211308","matrix metallopeptidase 2 [Source:MGI Symbol;Acc:MGI:97009]",12.45420656,15.87113411,25.90371741,18.78225834,16.51879933,19.24298906,0.994225059,-0.008355629,"down"]
["Mmp3","ENSMUST00000034497","matrix metallopeptidase 3 [Source:MGI Symbol;Acc:MGI:97010]",1.655063,3.118518,6.437961,6.549919,3.20841,4.990748,0.76015211,-0.395639958,"down"]
["Ezr","ENSMUST00000064234;ENSMUST00000131131","ezrin [Source:MGI Symbol;Acc:MGI:98931]",92.8866341717325,82.6344687264438,104.325402117021,103.369791463222,94.5005567069909,100.88656734924,0.936703020007501,-0.0943363783531033,"down"]
["Rdx","ENSMUST00000000590;ENSMUST00000163153;ENSMUST00000238858;ENSMUST00000061352","radixin [Source:MGI Symbol;Acc:MGI:97887]",18.7921776866019,15.991880113694,12.5172429072274,18.4200017669062,19.7729120483939,19.0607983782756,0.826170022785542,-0.275489381296144,"down"]
["Msn","ENSMUST00000149985;ENSMUST00000117399;ENSMUST00000135027","moesin [Source:MGI Symbol;Acc:MGI:97167]",194.948277141299,235.174466656709,218.732294008851,206.215217246562,227.630225673305,237.0092407841,0.967206540504954,-0.0481040943841167,"down"]
["Twist1","ENSMUST00000049089","twist basic helix-loop-helix transcription factor 1 [Source:MGI Symbol;Acc:MGI:98872]",0.0001,0.0001,0.0001,0.244707,0.0001,0.079091,0.000926217512920734,-10.0763613437721,"down"]

{"sheet":"Sheet2","index":1,"n_rows":0,"n_cols":0,"rows_kept":0,"flags":["formulas_cached_only"]}

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