{"text_format":"3","workbook":"xls","n_sheets":4,"sheets":["up-regulated mRNA","down-regulated mRNA","Luxi-specific-mRNA","Shandong-specific-mRNA"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"up-regulated mRNA","index":0,"n_rows":940,"n_cols":42,"rows_kept":940,"flags":["formulas_cached_only"]}
["Gene","L1_count","L2_count","L3_count","L_normalize","B1_count","B2_count","B3_count","B_normalize","FoldChange","Log2FoldChange","pval","padj","Up/Down","Significant","GeneName","Biotype","Position","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["gene10051",3225,8654,9631,6634.46718793025,2371,2944,2957,3034.01237608952,2.1866974703911,1.12875363732378,{"v":3.10309780292399e-05,"d":"3.10E-05"},0.0010903261504338,"up","yes","CDC34","protein_coding","chrNC_037334.1:43173737-43180341:+","gi|528956540|ref|XP_005209375.1|",1294,{"v":1e-173,"d":"1.00E-173"},"PREDICTED: ubiquitin-conjugating enzyme E2 R1 isoform X1 [Bos taurus]","gi|741933475|ref|XM_005209318.2|",1650,0,"PREDICTED: Bos taurus cell division cycle 34 (CDC34), transcript variant X1, mRNA","P49427",396,{"v":4e-134,"d":"4.00E-134"},"Ubiquitin-conjugating enzyme E2 R1","SPBC1105.09",157,{"v":5e-44,"d":"5.00E-44"},"COG5078","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.","GO:0006464|cellular protein modification process;GO:0035458|cellular response to interferon-beta;GO:0006270|DNA replication initiation;GO:0000082|G1/S transition of mitotic cell cycle;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0090261|positive regulation of inclusion body assembly;GO:0043525|positive regulation of neuron apoptotic process;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936|protein K48-linked ubiquitination;GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0070848|response to growth factor;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0061631|ubiquitin conjugating enzyme activity;GO:0061630|ubiquitin protein ligase activity;GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;","K02207","UBE2R, UBC3, CDC34; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]"]
["gene10083",672,1954,2043,1442.94865778497,538,609,621,648.746825763502,2.22420919915374,1.15329248787605,{"v":1.23270746877482e-05,"d":"1.23E-05"},0.000511197337087417,"up","yes","GPX4","protein_coding","chrNC_037334.1:43588660-43591107:+","gi|965800774|ref|XP_014949301.1|",995,{"v":4e-132,"d":"4.00E-132"},"PREDICTED: phospholipid hydroperoxide glutathione peroxidase, mitochondrial isoform X2 [Ovis aries musimon]","gi|965800781|ref|XM_015093836.1|",808,0,"PREDICTED: Ovis aries musimon glutathione peroxidase 4 (GPX4), transcript variant X5, mRNA","Q9N2J2",354,{"v":3e-121,"d":"3.00E-121"},"Phospholipid hydroperoxide glutathione peroxidase","CC1730",139,{"v":7e-39,"d":"7.00E-39"},"COG0386","pfam00255","GSHPx","Glutathione peroxidase.","GO:0007275|multicellular organismal development;GO:0006979|response to oxidative stress;GO:0007283|spermatogenesis;","GO:0005739|mitochondrion;","GO:0004602|glutathione peroxidase activity;GO:0047066|phospholipid-hydroperoxide glutathione peroxidase activity;","K05361","GPX4; phospholipid-hydroperoxide glutathione peroxidase [EC:1.11.1.12]"]
["gene10136",1577,1533,2030,1536.85096293886,457,424,451,489.213519158428,3.14147279818152,1.65144108793106,{"v":3.84073700803387e-11,"d":"3.84E-11"},{"v":6.89182814944745e-09,"d":"6.89E-09"},"up","yes","C7H5orf15","protein_coding","chrNC_037334.1:45648089-45661066:-","gi|78369452|ref|NP_001030376.1|",1172,{"v":5e-153,"d":"5.00E-153"},"keratinocyte-associated transmembrane protein 2 [Bos taurus]","gi|78369451|ref|NM_001035299.1|",2146,0,"Bos taurus chromosome 7 open reading frame, human C5orf15 (C7H5orf15), mRNA","Q5R5B8",335,{"v":6e-108,"d":"6.00E-108"},"Keratinocyte-associated transmembrane protein 2",".",".",".",".","pfam14609","GCP5-Mod21","gamma-Tubulin ring complex non-core subunit mod21. GCP5-Mod21 is a non-core subunit of the larger gamma-tubulin ring complex that effects microtubule nucleation from both centrosomal and non-centrosomal sites. This subunit, unlike GCP2 and and GCP3 and others, is not thought to be essential for viability in the fission yeast, and may not be expressed in very high concentrations. Fission yeast can form a large gamma-Tubulin complex C similar to that found in higher eukaryotes and this complex is important for maintaining normal levels of microtubule nucleation in vivo.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene10163",24,576,118,231.260693672822,2,8,5,5.48830117455153,42.1370267989564,5.39701661564607,{"v":8.21072757511229e-16,"d":"8.21E-16"},{"v":3.25361483952123e-13,"d":"3.25E-13"},"up","yes","PITX1","protein_coding","chrNC_037334.1:46474414-46480622:-","gi|328802693|ref|NP_001192229.1|",1260,{"v":2e-166,"d":"2.00E-166"},"pituitary homeobox 1 [Bos taurus]","gi|328802692|ref|NM_001205300.1|",1940,0,"Bos taurus paired-like homeodomain 1 (PITX1), mRNA","P78337",485,{"v":5e-166,"d":"5.00E-166"},"Pituitary homeobox 1","YDL106c",52,{"v":4e-06,"d":"4.00E-06"},"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0009653|anatomical structure morphogenesis;GO:0014707|branchiomeric skeletal muscle development;GO:0051216|cartilage development;GO:0035116|embryonic hindlimb morphogenesis;GO:0048625|myoblast fate commitment;GO:0045892|negative regulation of transcription, DNA-templated;GO:0021983|pituitary gland development;GO:0001501|skeletal system development;","GO:0005737|cytoplasm;GO:0005730|nucleolus;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001085|RNA polymerase II transcription factor binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001190|transcriptional activator activity, RNA polymerase II transcription factor binding;","K09356","PITX1; paired-like homeodomain transcription factor 1"]
["gene10198",88,34,18,39.6054353395566,6,14,9,10.6291905030407,3.72610080967376,1.89766670692823,0.0027891635648277,0.0391237097679936,"up","yes","KIF20A","protein_coding","chrNC_037334.1:49613158-49621659:+","gi|114052799|ref|NP_001039753.1|",4227,0,"kinesin-like protein KIF20A [Bos taurus]","gi|402745258|ref|NM_001046288.2|",2753,0,"Bos taurus kinesin family member 20A (KIF20A), mRNA","Q29RT6",1632,0,"Kinesin-like protein KIF20A","YGL216w",113,{"v":1e-24,"d":"1.00E-24"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0000920|cell separation after cytokinesis;GO:0001578|microtubule bundle formation;GO:0007018|microtubule-based movement;GO:0000281|mitotic cytokinesis;GO:0015031|protein transport;GO:0032465|regulation of cytokinesis;","GO:0032154|cleavage furrow;GO:0005794|Golgi apparatus;GO:0045171|intercellular bridge;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0030496|midbody;GO:0005654|nucleoplasm;GO:0005819|spindle;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0019901|protein kinase binding;","K10402","KIF20; kinesin family member 20"]
["gene1029",335,122,159,176.122680947023,78,50,85,78.1859850024187,2.25261190917495,1.17159878053437,0.00125908414861869,0.0217188209457315,"up","yes","CHST2","protein_coding","chrNC_037328.1:125870582-125875385:-","gi|594110557|ref|XP_006078117.1|",2032,0,"PREDICTED: carbohydrate sulfotransferase 2 [Bubalus bubalis]","gi|982911891|ref|XM_005201895.3|",4680,0,"PREDICTED: Bos taurus carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 (CHST2), transcript variant X1, mRNA","Q80WV3",773,0,"Carbohydrate sulfotransferase 2",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.","GO:0005975|carbohydrate metabolic process;GO:0006954|inflammatory response;GO:0006044|N-acetylglucosamine metabolic process;GO:0006790|sulfur compound metabolic process;","GO:0005794|Golgi apparatus;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0005802|trans-Golgi network;","GO:0001517|N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008146|sulfotransferase activity;","K04745","CHST2; carbohydrate 6-sulfotransferase 2 [EC:2.8.2.-]"]
["gene10295",246,167,114,153.854034920532,71,39,70,66.118151785442,2.32695607432886,1.21844397741879,0.00262678298859397,0.0374389004424663,"up","yes","PCDHB8","protein_coding","chrNC_037334.1:52294623-52299646:+","gi|528907665|ref|XP_005199130.1|",3780,0,"PREDICTED: protocadherin beta-8 [Bos taurus]","gi|741880955|ref|XM_005199073.2|",5024,0,"PREDICTED: Bos taurus protocadherin beta-8 (LOC518612), mRNA","Q5DRC6",1198,0,"Protocadherin beta-8",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007268|synaptic transmission;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007416|synapse assembly;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;",".","."]
["gene10300",42,39,42,36.6262740477182,3,6,9,6.57198568057049,5.57309096944636,2.47847770268894,0.000372767377201976,0.0083611839928849,"up","yes","PCDHB11","protein_coding","chrNC_037334.1:52338792-52341713:+","gi|296485288|tpg|DAA27403.1|",3731,0,"TPA: protocadherin beta 11 [Bos taurus]","gi|157074017|ref|NM_001103248.1|",2919,0,"Bos taurus protocadherin beta 11 (PCDHB11), mRNA","Q5DRD4",1141,0,"Protocadherin beta-18",".",".",".",".","pfam08266","Cadherin_2","Cadherin-like. This cadherin domain is usually the most N-terminal copy of the domain.","GO:0007155|cell adhesion;GO:0007268|synaptic transmission;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007416|synapse assembly;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;",".","."]
["gene10317",2333,529,711,999.760145334529,407,351,384,419.549838586588,2.38293535924742,1.25273981675771,{"v":3.8917219069343e-06,"d":"3.89E-06"},0.00018980293628503,"up","yes","ARAP3","protein_coding","chrNC_037334.1:52747343-52773635:-","gi|742166270|ref|XP_010848701.1|",6309,0,"PREDICTED: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2 [Bison bison bison]","gi|742166269|ref|XM_010850399.1|",3965,0,"PREDICTED: Bison bison bison ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 (ARAP3), transcript variant X2, mRNA","Q8WWN8",2175,0,"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007010|cytoskeleton organization;GO:0030336|negative regulation of cell migration;GO:0035021|negative regulation of Rac protein signal transduction;GO:0035024|negative regulation of Rho protein signal transduction;GO:0008360|regulation of cell shape;GO:0051056|regulation of small GTPase mediated signal transduction;GO:0007165|signal transduction;GO:0016192|vesicle-mediated transport;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0030027|lamellipodium;GO:0005886|plasma membrane;GO:0001726|ruffle;","GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;","K12490","ARAP3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3"]
["gene10318",1218,810,465,725.701982251612,235,344,302,323.093037238696,2.24610839173075,1.16742755037395,{"v":1.50052667340992e-05,"d":"1.50E-05"},0.000600442167167721,"up","yes","PCDH1","protein_coding","chrNC_037334.1:52931942-52958349:-","gi|803244804|ref|XP_011982423.1|",5773,0,"PREDICTED: protocadherin-1 isoform X2 [Ovis aries musimon]","gi|965822945|ref|XM_012127034.2|",3800,0,"PREDICTED: Ovis aries musimon protocadherin 1 (PCDH1), transcript variant X3, mRNA","Q08174",1835,0,"Protocadherin-1",".",".",".",".","pfam08374","Protocadherin","Protocadherin. The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organisms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.","GO:0007267|cell-cell signaling;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007399|nervous system development;","GO:0030054|cell junction;GO:0005911|cell-cell junction;GO:0005887|integral component of plasma membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005730|nucleolus;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;","K16498","PCDHD1; protocadherin delta 1"]
["gene10322",742,61,135,254.834640701165,110,66,77,93.1305818845402,2.73631534931349,1.45223450459295,0.000318301692143444,0.00734152431571915,"up","yes","PCDH12","protein_coding","chrNC_037334.1:53008892-53021807:-","gi|296485227|tpg|DAA27342.1|",5807,0,"TPA: protocadherin 12 [Bos taurus]","gi|148229402|ref|NM_001098111.1|",4007,0,"Bos taurus protocadherin 12 (PCDH12), mRNA","Q9NPG4",1910,0,"Protocadherin-12",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007155|cell adhesion;GO:0007267|cell-cell signaling;GO:0005977|glycogen metabolic process;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0060711|labyrinthine layer development;GO:0008038|neuron recognition;","GO:0005911|cell-cell junction;GO:0070062|extracellular exosome;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;","K16499","PCDHD2; protocadherin delta 2"]
["gene10353",662,1239,1773,1123.1014437097,39,75,65,65.5642609408795,17.1297811886024,4.0984348178134,{"v":3.05242162973267e-24,"d":"3.05E-24"},{"v":4.58361271146856e-21,"d":"4.58E-21"},"up","yes","SH3RF2","protein_coding","chrNC_037334.1:57145438-57294268:+","gi|139948524|ref|NP_001077222.1|",3243,0,"putative E3 ubiquitin-protein ligase SH3RF2 [Bos taurus]","gi|982932257|ref|XM_005209539.3|",5327,0,"PREDICTED: Bos taurus SH3 domain containing ring finger 2 (SH3RF2), transcript variant X1, mRNA","Q8TEC5",1082,0,"Putative E3 ubiquitin-protein ligase SH3RF2",".",".",".",".","pfam07653","SH3_2","Variant SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0010923|negative regulation of phosphatase activity;GO:0016567|protein ubiquitination;","GO:0005654|nucleoplasm;","GO:0046872|metal ion binding;GO:0019902|phosphatase binding;GO:0008157|protein phosphatase 1 binding;GO:0004864|protein phosphatase inhibitor activity;GO:0016740|transferase activity;","K12171","SH3RF, POSH; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]"]
["gene10411",1558,3929,1991,2305.13293710725,233,705,470,515.47145872366,4.47189247454147,2.16088549938173,0.00104922043096691,0.0187329838022008,"up","yes","PPARGC1B","protein_coding","chrNC_037334.1:61073681-61194295:+","gi|528957352|ref|XP_005209687.1|",4129,0,"PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform X1 [Bos taurus]","gi|982985579|ref|XM_010798507.2|",10463,0,"PREDICTED: Bos taurus peroxisome proliferator-activated receptor gamma, coactivator 1 beta (PPARGC1B), transcript variant X1, mRNA","Q86YN6",1188,0,"Peroxisome proliferator-activated receptor gamma coactivator 1-beta",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0007015|actin filament organization;GO:0060346|bone trabecula formation;GO:0034614|cellular response to reactive oxygen species;GO:0030520|intracellular estrogen receptor signaling pathway;GO:0006390|transcription from mitochondrial promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0001503|ossification;GO:0010694|positive regulation of alkaline phosphatase activity;GO:0045780|positive regulation of bone resorption;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0045672|positive regulation of osteoclast differentiation;GO:0042327|positive regulation of phosphorylation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006355|regulation of transcription, DNA-templated;GO:0051591|response to cAMP;GO:0051384|response to glucocorticoid;","GO:0016592|mediator complex;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0050682|AF-2 domain binding;GO:0030331|estrogen receptor binding;GO:0030374|ligand-dependent nuclear receptor transcription coactivator activity;GO:0003723|RNA binding;GO:0001104|RNA polymerase II transcription cofactor activity;GO:0008134|transcription factor binding;","K17962","PPARGC1B, PGC1B; peroxisome proliferator-activated receptor gamma coactivator 1-beta"]
["gene1042",5714,8263,5990,6036.79094387871,2261,3308,2643,3013.13587430702,2.00349111215141,1.00251610972702,0.000157223666200695,0.00422268842172665,"up","yes","TFDP2","protein_coding","chrNC_037328.1:126827531-127032524:+","gi|528937716|ref|XP_005201914.1|",1606,0,"PREDICTED: transcription factor Dp-2 isoform X5 [Bos taurus]","gi|982911818|ref|XM_015473189.1|",7353,0,"PREDICTED: Bos taurus transcription factor Dp-2 (E2F dimerization partner 2) (TFDP2), transcript variant X11, mRNA","Q14188",603,0,"Transcription factor Dp-2",".",".",".",".","pfam08781","DP","Transcription factor DP. DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer and negatively regulates the G1-S transition.","GO:0006977|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;GO:0007507|heart development;GO:0070317|negative regulation of G0 to G1 transition;GO:0045892|negative regulation of transcription, DNA-templated;GO:1900740|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0000083|regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0090575|RNA polymerase II transcription factor complex;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019904|protein domain specific binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003712|transcription cofactor activity;GO:0008134|transcription factor binding;","K09392","TFDP2; transcription factor Dp-2"]
["gene10434",8861,7331,6726,6777.58091551729,394,1592,872,1046.27719609527,6.47780620739071,2.69550530854396,{"v":3.39080827333728e-05,"d":"3.39E-05"},0.00116922948335355,"up","yes","MYOZ3","protein_coding","chrNC_037334.1:62030519-62047849:+","gi|118151164|ref|NP_001071507.1|",1288,{"v":4e-165,"d":"4.00E-165"},"myozenin-3 [Bos taurus]","gi|982932357|ref|XM_005209613.3|",3613,0,"PREDICTED: Bos taurus myozenin 3 (MYOZ3), transcript variant X2, mRNA","Q8TDC0",387,{"v":3e-123,"d":"3.00E-123"},"Myozenin-3",".",".",".",".","pfam05556","Calsarcin","Calcineurin-binding protein (Calsarcin). This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.","GO:0030239|myofibril assembly;","GO:0015629|actin cytoskeleton;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0051373|FATZ binding;GO:0031433|telethonin binding;",".","."]
["gene10593",28575,26420,17613,21514.9434099724,9009,9102,9985,10311.9118686232,2.08641653304247,1.06102720683456,0.000491708880902271,0.010444618940717,"up","yes","CKMT2","protein_coding","chrNC_037334.1:81249468-81274993:+","gi|823418135|ref|XP_004405665.2|",2150,0,"PREDICTED: LOW QUALITY PROTEIN: creatine kinase S-type, mitochondrial [Odobenus rosmarus divergens]","gi|402744050|ref|NM_001034656.2|",1468,0,"Bos taurus creatine kinase, mitochondrial 2 (CKMT2), mRNA","Q3ZBP1",826,0,"Creatine kinase S-type, mitochondrial","SA0482",95.1,{"v":1e-20,"d":"1.00E-20"},"COG3869","pfam00217","ATP-gua_Ptrans","ATP:guanido phosphotransferase, C-terminal catalytic domain. The substrate binding site is located in the cleft between N and C-terminal domains, but most of the catalytic residues are found in the larger C-terminal domain.",".","GO:0005743|mitochondrial inner membrane;","GO:0005524|ATP binding;GO:0004111|creatine kinase activity;","K00933","E2.7.3.2; creatine kinase [EC:2.7.3.2]"]
["gene1064",122,106,117,102.467340022064,37,30,29,35.307260171668,2.90216061863355,1.53712736685251,0.00054139935587426,0.0112176216575516,"up","yes","CLSTN2","protein_coding","chrNC_037328.1:128383077-129107976:-","gi|528937756|ref|XP_005201934.1|",4838,0,"PREDICTED: calsyntenin-2 isoform X1 [Bos taurus]","gi|982911843|ref|XM_005201877.3|",5277,0,"PREDICTED: Bos taurus calsyntenin 2 (CLSTN2), transcript variant X1, mRNA","Q9H4D0",1761,0,"Calsyntenin-2",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0051965|positive regulation of synapse assembly;GO:0050806|positive regulation of synaptic transmission;","GO:0009986|cell surface;GO:0005789|endoplasmic reticulum membrane;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;","GO:0005509|calcium ion binding;",".","."]
["gene10680",1743,2818,4213,2671.67816420062,1142,609,954,994.706724090102,2.68589534934984,1.42540309407463,0.000647513327299765,0.0129917037561108,"up","yes","ELL2","protein_coding","chrNC_037334.1:95212710-95286564:-","gi|329755297|ref|NP_001178075.1|",2939,0,"RNA polymerase II elongation factor ELL2 [Bos taurus]","gi|742237677|ref|XM_010832000.1|",5499,0,"PREDICTED: Bison bison bison elongation factor, RNA polymerase II, 2 (ELL2), mRNA","O00472",1065,0,"RNA polymerase II elongation factor ELL2",".",".",".",".","pfam10390","ELL","RNA polymerase II elongation factor ELL. ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.","GO:0006355|regulation of transcription, DNA-templated;GO:0042795|snRNA transcription from RNA polymerase II promoter;GO:0006368|transcription elongation from RNA polymerase II promoter;","GO:0005654|nucleoplasm;GO:0008023|transcription elongation factor complex;",".","K15183","ELL; RNA polymerase II elongation factor ELL"]
["gene10687",937,2347,2611,1815.25195136415,584,462,504,569.759157321529,3.18599872952943,1.67174569156442,{"v":6.62011672492127e-11,"d":"6.62E-11"},{"v":1.13782259204053e-08,"d":"1.14E-08"},"up","yes","ERAP2","protein_coding","chrNC_037334.1:96304223-96357020:+","gi|164420777|ref|NP_001069096.2|",5130,0,"endoplasmic reticulum aminopeptidase 2 [Bos taurus]","gi|164420776|ref|NM_001075628.2|",4016,0,"Bos taurus endoplasmic reticulum aminopeptidase 2 (ERAP2), mRNA","A6QPT7",1980,0,"Endoplasmic reticulum aminopeptidase 2","YKL157w",412,{"v":3e-122,"d":"3.00E-122"},"COG0308","pfam01433","Peptidase_M1","Peptidase family M1. Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase, this enzyme also has an aminopeptidase activity.","GO:0002250|adaptive immune response;GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0007267|cell-cell signaling;GO:0043171|peptide catabolic process;GO:0006508|proteolysis;GO:0008217|regulation of blood pressure;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0070006|metalloaminopeptidase activity;GO:0042277|peptide binding;GO:0008270|zinc ion binding;","K13723","ERAP2; endoplasmic reticulum aminopeptidase 2 [EC:3.4.11.-]"]
["gene10688",7467,10827,9464,8400.87216269283,3120,4574,3558,4129.09911905119,2.03455328159408,1.02471206270948,0.000181328221991097,0.00467764511901265,"up","yes","LNPEP","protein_coding","chrNC_037334.1:96372274-96475051:+","gi|528907948|ref|XP_599899.4|",5168,0,"PREDICTED: leucyl-cystinyl aminopeptidase [Bos taurus]","gi|742237504|ref|XM_010831959.1|",5982,0,"PREDICTED: Bison bison bison leucyl/cystinyl aminopeptidase (LNPEP), transcript variant X1, mRNA","Q9UIQ6",1764,0,"Leucyl-cystinyl aminopeptidase","SPBC1921.05",402,{"v":3e-117,"d":"3.00E-117"},"COG0308","pfam01433","Peptidase_M1","Peptidase family M1. Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase, this enzyme also has an aminopeptidase activity.","GO:0002480|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent;GO:0007267|cell-cell signaling;GO:0007565|female pregnancy;GO:0043171|peptide catabolic process;GO:0030163|protein catabolic process;GO:0000209|protein polyubiquitination;GO:0006508|proteolysis;GO:0008217|regulation of blood pressure;GO:0007165|signal transduction;GO:0060395|SMAD protein signal transduction;","GO:0030659|cytoplasmic vesicle membrane;GO:0005829|cytosol;GO:0031905|early endosome lumen;GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0005765|lysosomal membrane;GO:0016020|membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0004177|aminopeptidase activity;GO:0070006|metalloaminopeptidase activity;GO:0008237|metallopeptidase activity;GO:0042277|peptide binding;GO:0008270|zinc ion binding;","K01257","LNPEP; cystinyl aminopeptidase [EC:3.4.11.3]"]
["gene10695",4392,2153,2295,2555.07756864703,1070,1210,1115,1246.47158560042,2.049848226116,1.03551709434742,{"v":2.41863612384163e-05,"d":"2.42E-05"},0.000885061577560413,"up","yes","RGMB","protein_coding","chrNC_037334.1:98006658-98035622:+","gi|594097223|ref|XP_006071854.1|",2064,0,"PREDICTED: RGM domain family member B [Bubalus bubalis]","gi|982985796|ref|XM_015464390.1|",3954,0,"PREDICTED: Bos taurus repulsive guidance molecule family member b (RGMB), mRNA","Q6NW40",736,0,"RGM domain family member B",".",".",".",".","pfam06534","RGM_C","Repulsive guidance molecule (RGM) C-terminus. This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but RGMA from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.","GO:0030509|BMP signaling pathway;GO:0007155|cell adhesion;GO:0045893|positive regulation of transcription, DNA-templated;GO:0007165|signal transduction;","GO:0046658|anchored component of plasma membrane;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0045121|membrane raft;GO:0005886|plasma membrane;","GO:0015026|coreceptor activity;GO:0042802|identical protein binding;","K06847","RGM; RGM domain family"]
["gene10762",38,18,52,31.772926173116,4,2,2,2.95099327562491,10.7668582085764,3.42852542479178,{"v":1.86875057236895e-05,"d":"1.87E-05"},0.000719532018626971,"up","yes","LOC781533","transcribed_pseudogene","chrNC_037334.1:110516391-110518918:-","gi|594034437|ref|XP_006041928.1|",1797,0,"PREDICTED: nucleolin [Bubalus bubalis]","gi|982990098|ref|XR_083329.4|",2479,0,"PREDICTED: Bos taurus nucleolin pseudogene (LOC781533), misc_RNA","Q4R4J7",677,0,"Nucleolin",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".","GO:0005737|cytoplasm;GO:0005730|nucleolus;","GO:0003723|RNA binding;GO:0042162|telomeric DNA binding;","K11294","NCL, NSR1; nucleolin"]
["gene10823",0,35,0,11.4701187722307,0,0,0,0,"Inf","Inf",0.000250883749010672,0.00603029843557159,"up","yes","LOC112447767","protein_coding","chrNC_037335.1:7285081-7289573:+","gi|296484965|tpg|DAA27080.1|",3265,0,"TPA: ADAM metallopeptidase domain 21 preproprotein-like [Bos taurus]","gi|965920941|ref|XM_012129126.2|",1755,0,"PREDICTED: Ovis aries disintegrin and metalloproteinase domain-containing protein 20-like (LOC101111693), transcript variant X4, mRNA","O43506",701,0,"Disintegrin and metalloproteinase domain-containing protein 20",".",".",".",".","pfam01562","Pep_M12B_propep","Reprolysin family propeptide. This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the \"cysteine switch\" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.","GO:0007339|binding of sperm to zona pellucida;GO:0007338|single fertilization;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0046872|metal ion binding;GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;","K08609","ADAM20; disintegrin and metalloproteinase domain-containing protein 20 [EC:3.4.24.-]"]
["gene10844",630,203,209,294.907749509845,95,136,95,119.710702353186,2.4635036276019,1.30071159607445,{"v":8.20162152694483e-05,"d":"8.20E-05"},0.00246575831175198,"up","yes","SOX7","protein_coding","chrNC_037335.1:8558547-8565620:+","gi|594081522|ref|XP_006064379.1|",1900,0,"PREDICTED: transcription factor SOX-7 [Bubalus bubalis]","gi|982985917|ref|XM_015464423.1|",2221,0,"PREDICTED: Bos taurus SRY-box 7 (SOX7), mRNA","Q9BT81",666,0,"Transcription factor SOX-7",".",".",".",".","pfam12067","Sox_C_TAD","Sox C-terminal transactivation domain. This domain is found at the C-terminus of the Sox family of transcription factors. It is found associated with pfam00505. It binds to the Armadillo repeats (pfam00514) in Catenin beta-1 (CTNNB1), which is involved in transcriptional regulation. It functions as a transactivating domain (TAD).","GO:0001706|endoderm formation;GO:0008285|negative regulation of cell proliferation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060828|regulation of canonical Wnt signaling pathway;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0044212|transcription regulatory region DNA binding;","K09270","SOX7S; transcription factor SOX7/8/10/18 (SOX group E/F)"]
["gene10910",517,723,548,539.984750727927,184,238,213,233.003595254047,2.31749535941355,1.21256644998014,{"v":2.22838950579314e-05,"d":"2.23E-05"},0.000831932667725762,"up","yes","MOB3B","protein_coding","chrNC_037335.1:16756977-16997832:+","gi|114051049|ref|NP_001039956.1|",1176,{"v":8e-145,"d":"8.00E-145"},"MOB kinase activator 3B [Bos taurus]","gi|982933019|ref|XM_015472417.1|",6296,0,"PREDICTED: Bos taurus MOB kinase activator 3B (MOB3B), transcript variant X1, mRNA","Q29RK9",457,{"v":3e-146,"d":"3.00E-146"},"MOB kinase activator 3B",".",".",".",".","pfam03637","Mob1_phocein","Mob1/phocein family. Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.",".",".","GO:0046872|metal ion binding;",".","."]
["gene11048",3479,12845,3271,6120.83669389395,2125,2133,2223,2379.48440732892,2.57233738327576,1.36307987643621,{"v":4.09042550757082e-07,"d":"4.09E-07"},{"v":2.81893551102665e-05,"d":"2.82E-05"},"up","yes","BNC2","protein_coding","chrNC_037335.1:27468445-27953748:+","gi|982933151|ref|XP_015327920.1|",4144,0,"PREDICTED: zinc finger protein basonuclin-2 isoform X5 [Bos taurus]","gi|982986096|ref|XM_015464467.1|",11953,0,"PREDICTED: Bos taurus basonuclin 2 (BNC2), transcript variant X6, mRNA","Q6ZN30",1563,0,"Zinc finger protein basonuclin-2",".",".",".",".","pfam13894","zf-C2H2_4","C2H2-type zinc finger. This family contains a number of divergent C2H2 type zinc fingers.","GO:0003416|endochondral bone growth;GO:0060485|mesenchyme development;GO:0060021|palate development;GO:0043586|tongue development;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["gene11071",169,5,27,53.9761995287714,5,5,8,6.59156140349758,8.18868189563262,3.03363124482417,{"v":3.00304467179424e-06,"d":"3.00E-06"},0.000153121846757502,"up","yes","TYRP1","protein_coding","chrNC_037335.1:31632079-31648318:-","gi|982933191|ref|XP_015327928.1|",2963,0,"PREDICTED: 5,6-dihydroxyindole-2-carboxylic acid oxidase isoform X1 [Bos taurus]","gi|982933192|ref|XM_015472443.1|",1993,0,"PREDICTED: Bos taurus tyrosinase-related protein 1 (TYRP1), transcript variant X2, mRNA","Q8WN57",1082,0,"5,6-dihydroxyindole-2-carboxylic acid oxidase",".",".",".",".","pfam00264","Tyrosinase","Common central domain of tyrosinase. This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to pfam00372.","GO:0042438|melanin biosynthetic process;","GO:0016021|integral component of membrane;GO:0042470|melanosome;GO:0033162|melanosome membrane;","GO:0046872|metal ion binding;GO:0004497|monooxygenase activity;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;","K00506","TYRP1; tyrosinase-related protein 1 [EC:1.14.18.-]"]
["gene11083",865,482,459,524.367851067019,178,290,222,253.093096296468,2.07183782860985,1.05091108168433,0.0010909350167096,0.0193086023335866,"up","yes","PTPRD","protein_coding","chrNC_037335.1:36028647-36603746:+","gi|982933219|ref|XP_015327935.1|",10125,0,"PREDICTED: receptor-type tyrosine-protein phosphatase delta isoform X7 [Bos taurus]","gi|982986133|ref|XM_015464476.1|",9652,0,"PREDICTED: Bos taurus protein tyrosine phosphatase, receptor type D (PTPRD), transcript variant X7, mRNA","P23468",3808,0,"Receptor-type tyrosine-protein phosphatase delta","SPAC11E3.09",142,{"v":6e-35,"d":"6.00E-35"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0030182|neuron differentiation;GO:0006796|phosphate-containing compound metabolic process;GO:0050775|positive regulation of dendrite morphogenesis;GO:0051965|positive regulation of synapse assembly;GO:0097105|presynaptic membrane assembly;GO:0006470|protein dephosphorylation;GO:0007185|transmembrane receptor protein tyrosine phosphatase signaling pathway;","GO:0070062|extracellular exosome;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0050839|cell adhesion molecule binding;GO:0005102|receptor binding;GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;","K06777","PTPRD; receptor-type tyrosine-protein phosphatase delta [EC:3.1.3.48]"]
["gene1119",56,141,154,108.099825606605,18,11,20,17.9841466512766,6.01083986372695,2.58756658537571,{"v":4.63103212696224e-08,"d":"4.63E-08"},{"v":4.22134113783897e-06,"d":"4.22E-06"},"up","yes","EPHB1","protein_coding","chrNC_037328.1:134087021-134553122:-","gi|330417933|ref|NP_001179758.2|",5022,0,"ephrin type-B receptor 1 precursor [Bos taurus]","gi|330417932|ref|NM_001192829.2|",4274,0,"Bos taurus EPH receptor B1 (EPHB1), mRNA","P54762",1923,0,"Ephrin type-B receptor 1",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001525|angiogenesis;GO:0007411|axon guidance;GO:0048593|camera-type eye morphogenesis;GO:0060326|cell chemotaxis;GO:0031589|cell-substrate adhesion;GO:0021952|central nervous system projection neuron axonogenesis;GO:0060996|dendritic spine development;GO:0060997|dendritic spine morphogenesis;GO:0050965|detection of temperature stimulus involved in sensory perception of pain;GO:0048013|ephrin receptor signaling pathway;GO:0030010|establishment of cell polarity;GO:0001771|immunological synapse formation;GO:1902725|negative regulation of satellite cell differentiation;GO:1902723|negative regulation of skeletal muscle satellite cell proliferation;GO:0061351|neural precursor cell proliferation;GO:0022008|neurogenesis;GO:0021631|optic nerve morphogenesis;GO:0051965|positive regulation of synapse assembly;GO:0046777|protein autophosphorylation;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0046328|regulation of JNK cascade;GO:1901214|regulation of neuron death;GO:0031290|retinal ganglion cell axon guidance;GO:0014719|skeletal muscle satellite cell activation;","GO:0030424|axon;GO:0005829|cytosol;GO:0030425|dendrite;GO:0031901|early endosome membrane;GO:0005783|endoplasmic reticulum;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0032433|filopodium tip;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0008046|axon guidance receptor activity;GO:0004713|protein tyrosine kinase activity;GO:0044877|macromolecular complex binding;GO:0005005|transmembrane-ephrin receptor activity;","K05110","EPHB1, ELK, NET; Eph receptor B1 [EC:2.7.10.1]"]
["gene1121",2134,1101,718,1137.50048514555,13,99,27,50.937022490596,22.3315072127656,4.48100872065595,{"v":6.3341474217379e-05,"d":"6.33E-05"},0.00198313643538933,"up","yes","KY","protein_coding","chrNC_037328.1:134699347-134745982:+","gi|803292935|ref|XP_012006131.1|",3542,0,"PREDICTED: kyphoscoliosis peptidase isoform X2 [Ovis aries musimon]","gi|594069494|ref|XM_006058588.1|",4979,0,"PREDICTED: Bubalus bubalis kyphoscoliosis peptidase (KY), mRNA","Q8C8H8",1216,0,"Kyphoscoliosis peptidase","sll1681",132,{"v":5e-31,"d":"5.00E-31"},"COG5279","pfam01841","Transglut_core","Transglutaminase-like superfamily. This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterized transglutaminase, the human blood clotting factor XIIIa'. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase, it is proposed that many, if not all, microbial homologues of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease.","GO:0007517|muscle organ development;GO:0007528|neuromuscular junction development;","GO:0005856|cytoskeleton;GO:0030018|Z disc;","GO:0008233|peptidase activity;",".","."]
["gene11239",672,701,886,676.978675654533,181,294,239,261.818889946685,2.58567544836962,1.3705412007428,{"v":1.10486709383404e-05,"d":"1.10E-05"},0.00046700686006191,"up","yes","TLE1","protein_coding","chrNC_037335.1:57578659-57625491:-","gi|62089294|dbj|BAD93091.1|",758,{"v":1e-88,"d":"1.00E-88"},"transducin-like enhancer protein 1 variant [Homo sapiens]","gi|402692075|ref|NM_001098020.2|",1621,0,"Bos taurus transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) (TLE1), mRNA","Q04724",261,{"v":8e-76,"d":"8.00E-76"},"Transducin-like enhancer protein 1",".",".",".",".","pfam03920","TLE_N","Groucho/TLE N-terminal Q-rich domain. The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.","GO:0009887|organ morphogenesis;GO:0007275|multicellular organismal development;GO:2000811|negative regulation of anoikis;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045892|negative regulation of transcription, DNA-templated;GO:0030178|negative regulation of Wnt signaling pathway;GO:0010628|positive regulation of gene expression;GO:0007165|signal transduction;GO:0006351|transcription, DNA-templated;GO:0016055|Wnt signaling pathway;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0042802|identical protein binding;GO:0001106|RNA polymerase II transcription corepressor activity;GO:0008134|transcription factor binding;",".","."]
["gene11242",3,26,0,9.30252936988002,0,0,0,0,"Inf","Inf",0.00093928110864225,0.0172006606615353,"up","yes","LOC782251","protein_coding","chrNC_037335.1:57833482-57839539:+","gi|440896267|gb|ELR48246.1|",6463,0,"Protein FAM75D1 [Bos mutus]","gi|982986428|ref|XM_015464552.1|",4111,0,"PREDICTED: Bos taurus putative spermatogenesis-associated protein 31D3 (LOC782251), mRNA","Q6ZQQ2",712,0,"Spermatogenesis-associated protein 31D1",".",".",".",".","pfam14650","FAM75","FAM75 family.","GO:0030154|cell differentiation;GO:0007283|spermatogenesis;","GO:0016021|integral component of membrane;",".",".","."]
["gene11252",0,115,0,37.687533108758,0,0,0,0,"Inf","Inf",{"v":1.1720888569855e-10,"d":"1.17E-10"},{"v":1.87870040329513e-08,"d":"1.88E-08"},"up","yes","C8H9orf131","protein_coding","chrNC_037335.1:59313922-59318157:+","gi|528958832|ref|XP_005210189.1|",5706,0,"PREDICTED: uncharacterized protein C9orf131 homolog [Bos taurus]","gi|982986394|ref|XM_003582542.4|",3850,0,"PREDICTED: Bos taurus chromosome 8 open reading frame, human C9orf131 (C8H9orf131), mRNA",".",".",".",".",".",".",".",".","pfam14650","FAM75","FAM75 family.",".",".",".",".","."]
["gene11265",2797,6456,9826,5862.48570222185,1703,2267,2237,2275.98422795383,2.5758024287771,1.365021938967,{"v":2.79091566325397e-07,"d":"2.79E-07"},{"v":2.01588898198225e-05,"d":"2.02E-05"},"up","yes","RMRP","RNase_MRP_RNA","chrNC_037335.1:59833115-59833395:-","gi|431902819|gb|ELK09034.1|",147,{"v":2e-13,"d":"2.00E-13"},"hypothetical protein PAL_GLEAN10008241 [Pteropus alecto]","gi|307746910|ref|NR_036646.1|",274,{"v":4e-140,"d":"4.00E-140"},"Bos taurus RNA component of mitochondrial RNA processing endoribonuclease (RMRP), RNase MRP RNA",".",".",".",".",".",".",".",".","pfam05134","T2SL","Type II secretion system (T2SS), protein L. This family consists of Type II secretion system protein L sequences from several Gram-negative (diderm) bacteria. The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for extracellular secretion of a number of different proteins, including proteases and toxins. This pathway supports secretion of proteins across the cell envelope in two distinct steps, in which the second step, involving translocation through the outer membrane, is assisted by at least 13 different gene products. T2SL is predicted to contain a large cytoplasmic domain represented by this family and has been shown to interact with the autophosphorylating cytoplasmic membrane protein T2SE. It is thought that the tri-molecular complex of T2SL, T2SE (pfam00437) and T2SM (pfam04612) might be involved in regulating the opening and closing of the secretion pore and/or transducing energy to the site of outer membrane translocation.",".",".",".",".","."]
["gene11372",14449,9511,10343,10059.2270523889,2698,2384,2730,2868.780657267,3.50644690346316,1.81000988209896,{"v":4.41899169634508e-12,"d":"4.42E-12"},{"v":9.69832708372474e-10,"d":"9.70E-10"},"up","yes","COL15A1","protein_coding","chrNC_037335.1:63974716-64078125:+","gi|803013150|ref|XP_011975820.1|",4541,0,"PREDICTED: collagen alpha-1(XV) chain isoform X1 [Ovis aries]","gi|982933768|ref|XM_005210199.3|",5497,0,"PREDICTED: Bos taurus collagen type XV alpha 1 (COL15A1), transcript variant X2, mRNA","P39059",841,0,"Collagen alpha-1(XV) chain",".",".",".",".","pfam06482","Endostatin","Collagenase NC10 and Endostatin. NC10 stands for Non-helical region 10 and is taken from human COL15A1. A mutation in this region in human COL18A1 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumor suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor. Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance.","GO:0001525|angiogenesis;GO:0007155|cell adhesion;GO:0030154|cell differentiation;GO:0030574|collagen catabolic process;GO:0007165|signal transduction;","GO:0005582|collagen type XV trimer;GO:0005788|endoplasmic reticulum lumen;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016021|integral component of membrane;","GO:0005198|structural molecule activity;","K08135","COL15A; collagen, type XV, alpha"]
["gene11382",2520,669,738,1102.66944981924,405,254,327,362.629053572407,3.04076421609463,1.60443395268604,{"v":2.21049132448838e-06,"d":"2.21E-06"},0.000119446075717761,"up","yes","NR4A3","protein_coding","chrNC_037335.1:64872307-64914679:+","gi|982933789|ref|XP_015328049.1|",2905,0,"PREDICTED: nuclear receptor subfamily 4 group A member 3 isoform X1 [Bos taurus]","gi|982986514|ref|XM_015464574.1|",5885,0,"PREDICTED: Bos taurus nuclear receptor subfamily 4 group A member 3 (NR4A3), transcript variant X1, mRNA","Q92570",919,0,"Nuclear receptor subfamily 4 group A member 3",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0030534|adult behavior;GO:0031100|organ regeneration;GO:0007411|axon guidance;GO:0045333|cellular respiration;GO:0071870|cellular response to catecholamine stimulus;GO:0071376|cellular response to corticotropin-releasing hormone stimulus;GO:0044320|cellular response to leptin stimulus;GO:0035726|common myeloid progenitor cell proliferation;GO:0097009|energy homeostasis;GO:0045444|fat cell differentiation;GO:0007369|gastrulation;GO:0021766|hippocampus development;GO:0043303|mast cell degranulation;GO:0001707|mesoderm formation;GO:1903208|negative regulation of hydrogen peroxide-induced neuron death;GO:0043524|negative regulation of neuron apoptotic process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0050885|neuromuscular process controlling balance;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0010613|positive regulation of cardiac muscle hypertrophy;GO:0045787|positive regulation of cell cycle;GO:0050679|positive regulation of epithelial cell proliferation;GO:0046321|positive regulation of fatty acid oxidation;GO:2000253|positive regulation of feeding behavior;GO:0010828|positive regulation of glucose transport;GO:2000108|positive regulation of leukocyte apoptotic process;GO:0038097|positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway;GO:0032765|positive regulation of mast cell cytokine production;GO:1900625|positive regulation of monocyte aggregation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:0009444|pyruvate oxidation;GO:0045652|regulation of megakaryocyte differentiation;GO:0048660|regulation of smooth muscle cell proliferation;GO:0061469|regulation of type B pancreatic cell proliferation;GO:0042542|response to hydrogen peroxide;GO:0048752|semicircular canal morphogenesis;GO:0006367|transcription initiation from RNA polymerase II promoter;GO:0060005|vestibular reflex;","GO:0042629|mast cell granule;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0001046|core promoter sequence-specific DNA binding;GO:0003677|DNA binding;GO:0035259|glucocorticoid receptor binding;GO:0035035|histone acetyltransferase binding;GO:0042803|protein homodimerization activity;GO:0019901|protein kinase binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003707|steroid hormone receptor activity;GO:0004887|thyroid hormone receptor activity;GO:0001223|transcription coactivator binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0008270|zinc ion binding;","K08559","NR4A3, NOR1; nuclear receptor subfamily 4 group A member 3"]
["gene11399",0,47,0,15.4027309227098,0,0,0,0,"Inf","Inf",{"v":2.27192051612602e-05,"d":"2.27E-05"},0.000845112962784767,"up","yes","LOC112447816","protein_coding","chrNC_037335.1:66775761-66785299:+","gi|296484628|tpg|DAA26743.1|",9549,0,"TPA: hypothetical protein BOS_9029 [Bos taurus]","gi|555977179|ref|XM_005900486.1|",5428,0,"PREDICTED: Bos mutus spermatogenesis-associated protein 31E1 (LOC102286021), mRNA","Q6ZUB1",404,{"v":2e-114,"d":"2.00E-114"},"Spermatogenesis-associated protein 31E1",".",".",".",".","pfam14650","FAM75","FAM75 family.","GO:0030154|cell differentiation;GO:0007283|spermatogenesis;","GO:0016021|integral component of membrane;",".",".","."]
["gene11427",814,967,870,796.246131816499,129,77,115,117.98600861816,6.74864876896889,2.7545986711334,{"v":2.76073553736618e-16,"d":"2.76E-16"},{"v":1.15833155318521e-13,"d":"1.16E-13"},"up","yes","HR","protein_coding","chrNC_037335.1:69429336-69447956:-","gi|156523182|ref|NP_001096005.1|",5703,0,"lysine-specific demethylase hairless [Bos taurus]","gi|594047122|ref|XM_006047925.1|",4624,0,"PREDICTED: Bubalus bubalis hair growth associated (HR), transcript variant X1, mRNA","O43593",1712,0,"Lysine-specific demethylase hairless",".",".",".",".","pfam02373","JmjC","JmjC domain, hydroxylase. The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyse a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalyzing hydroxylation.","GO:0033169|histone H3-K9 demethylation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0000785|chromatin;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0031490|chromatin DNA binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0032454|histone demethylase activity (H3-K9 specific);GO:0046872|metal ion binding;GO:0016491|oxidoreductase activity;GO:0003714|transcription corepressor activity;GO:0000976|transcription regulatory region sequence-specific DNA binding;","K00478","HR; lysine-specific demethylase hairless [EC:1.14.11.-]"]
["gene11447",2794,6007,5381,4349.40293315957,671,1250,925,1043.43277157011,4.16835952604285,2.05947971717251,{"v":4.00423965742461e-07,"d":"4.00E-07"},{"v":2.77293596276654e-05,"d":"2.77E-05"},"up","yes","PEBP4","protein_coding","chrNC_037335.1:70019047-70263819:-","gi|77735827|ref|NP_001029612.1|",1029,{"v":2e-137,"d":"2.00E-137"},"phosphatidylethanolamine-binding protein 4 precursor [Bos taurus]","gi|77735826|ref|NM_001034440.1|",1049,0,"Bos taurus phosphatidylethanolamine binding protein 4 (PEBP4), mRNA","Q96S96",288,{"v":1e-94,"d":"1.00E-94"},"Phosphatidylethanolamine-binding protein 4",".",".",".",".","pfam01161","PBP","Phosphatidylethanolamine-binding protein.",".","GO:0070062|extracellular exosome;GO:0005764|lysosome;",".",".","."]
["gene11454",473,977,892,717.407460786795,296,324,290,334.221464698746,2.14650325176881,1.10198835834697,{"v":7.43053769786196e-05,"d":"7.43E-05"},0.00226738685623208,"up","yes","R3HCC1","protein_coding","chrNC_037335.1:70404873-70413064:+","gi|359068349|ref|XP_002689826.2|",2003,0,"PREDICTED: R3H and coiled-coil domain-containing protein 1 isoform X1 [Bos taurus]","gi|982986597|ref|XM_015464612.1|",1664,0,"PREDICTED: Bos taurus R3H domain and coiled-coil containing 1 (R3HCC1), transcript variant X1, mRNA","Q9Y3T6",556,0,"R3H and coiled-coil domain-containing protein 1",".",".",".",".","pfam01424","R3H","R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.",".","GO:0035145|exon-exon junction complex;","GO:0003676|nucleic acid binding;",".","."]
["gene11464",344,515,530,421.203464075345,133,108,120,132.662560059839,3.17499876291665,1.66675602976374,{"v":3.94692333581991e-08,"d":"3.95E-08"},{"v":3.66806741675172e-06,"d":"3.67E-06"},"up","yes","STC1","protein_coding","chrNC_037335.1:70977493-70990673:-","gi|803011834|ref|XP_004004231.2|",1411,0,"PREDICTED: stanniocalcin-1 [Ovis aries]","gi|91680536|ref|NM_176669.3|",2476,0,"Bos taurus stanniocalcin 1 (STC1), mRNA","Q9N0T1",511,{"v":8e-175,"d":"8.00E-175"},"Stanniocalcin-1",".",".",".",".","pfam03298","Stanniocalcin","Stanniocalcin family.","GO:0006874|cellular calcium ion homeostasis;GO:0035988|chondrocyte proliferation;GO:0001886|endothelial cell morphogenesis;GO:0003421|growth plate cartilage axis specification;GO:0051926|negative regulation of calcium ion transport;GO:0010596|negative regulation of endothelial cell migration;GO:1903403|negative regulation of renal phosphate excretion;GO:0090280|positive regulation of calcium ion import;GO:0044070|regulation of anion transport;GO:0086004|regulation of cardiac muscle cell contraction;","GO:0005737|cytoplasm;GO:0005615|extracellular space;GO:0005634|nucleus;","GO:0005179|hormone activity;",".","."]
["gene11465",30,32,47,32.7403796192781,0,0,1,0.360972888453242,90.7003840636609,6.50303675463306,{"v":6.73680307256723e-09,"d":"6.74E-09"},{"v":7.28059577512938e-07,"d":"7.28E-07"},"up","yes","LOC539009","protein_coding","chrNC_037335.1:71366038-71367425:-","gi|743702310|ref|XP_010944356.1|",1703,0,"PREDICTED: ras-related GTP-binding protein A [Camelus bactrianus]","gi|982986607|ref|XM_001790289.6|",1367,0,"PREDICTED: Bos taurus ras-related GTP-binding protein A (LOC539009), transcript variant X2, mRNA","Q63486",649,0,"Ras-related GTP-binding protein A",".",".",".",".","pfam04670","Gtr1_RagA","Gtr1/RagA G protein conserved region. GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1.    Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1. Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B.","GO:0006915|apoptotic process;GO:0008219|cell death;GO:0034613|cellular protein localization;GO:0034198|cellular response to amino acid starvation;GO:0071230|cellular response to amino acid stimulus;GO:0009267|cellular response to starvation;GO:0019048|modulation by virus of host morphology or physiology;GO:0010507|negative regulation of autophagy;GO:0045919|positive regulation of cytolysis;GO:0032008|positive regulation of TOR signaling;GO:1904263|positive regulation of TORC1 signaling;GO:0010506|regulation of autophagy;GO:1903432|regulation of TORC1 signaling;GO:0043200|response to amino acid;","GO:0005737|cytoplasm;GO:0034448|EGO complex;GO:1990130|Iml1 complex;GO:1990131|Gtr1-Gtr2 GTPase complex;GO:0005764|lysosome;GO:0005634|nucleus;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0051219|phosphoprotein binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0031625|ubiquitin protein ligase binding;","K16185","RRAGA_B; Ras-related GTP-binding protein A/B"]
["gene11478",34,94,25,47.3446927380533,12,6,17,12.8236815998604,3.69197350771471,1.8843922007557,0.00216986172787422,0.0326843407797304,"up","yes","CDCA2","protein_coding","chrNC_037335.1:72822079-72865586:+","gi|114051259|ref|NP_001039659.1|",4949,0,"cell division cycle-associated protein 2 [Bos taurus]","gi|742119261|ref|XM_010840167.1|",3605,0,"PREDICTED: Bison bison bison cell division cycle associated 2 (CDCA2), mRNA","Q29RT4",1907,0,"Cell division cycle-associated protein 2",".",".",".",".","pfam15276","PP1_bind","Protein phosphatase 1 binding. This domain contains a protein phosphatase 1 (PP1) binding site.","GO:0007049|cell cycle;GO:0051301|cell division;GO:0035307|positive regulation of protein dephosphorylation;","GO:0005634|nucleus;",".","K17590","CDCA2; cell division cycle-associated protein 2"]
["gene11523",1566,1206,1309,1205.38572840166,307,622,434,499.675305186901,2.41233800407805,1.27043206422102,0.00224919260197221,0.0335100334866157,"up","yes","MYORG","protein_coding","chrNC_037335.1:75740382-75764994:-","gi|741936412|ref|XP_010806407.1|",5107,0,"PREDICTED: spermatid-specific manchette-related protein 1 isoform X2 [Bos taurus]","gi|982934058|ref|XM_010808105.2|",5261,0,"PREDICTED: Bos taurus chromosome 8 open reading frame, human C9orf24 (C8H9orf24), transcript variant X3, mRNA","Q6NSJ0",1265,0,"Myogenesis-regulating glycosidase","TM0308",142,{"v":3e-33,"d":"3.00E-33"},"COG1501","pfam15181","SMRP1","Spermatid-specific manchette-related protein 1. This family of proteins, SMRP1, is thought to have a role in spermatogenesis and may be involved in differentiation or function of ciliated cells. This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 260 amino acids in length.","GO:0005975|carbohydrate metabolic process;GO:0043568|positive regulation of insulin-like growth factor receptor signaling pathway;GO:0051897|positive regulation of protein kinase B signaling;GO:0048741|skeletal muscle fiber development;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;","GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds;",".","."]
["gene11529",196,1017,416,512.133633753971,181,187,242,223.634138730175,2.29005122680255,1.19537987073593,{"v":8.5925171737702e-05,"d":"8.59E-05"},0.00256436304900458,"up","yes","CNTFR","protein_coding","chrNC_037335.1:75920612-75958539:-","gi|432110797|gb|ELK34274.1|",1731,0,"Ciliary neurotrophic factor receptor subunit alpha [Myotis davidii]","gi|514388116|ref|NM_001278571.1|",2054,0,"Bos taurus ciliary neurotrophic factor receptor (CNTFR), mRNA","P26992",615,0,"Ciliary neurotrophic factor receptor subunit alpha",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0003360|brainstem development;GO:0070120|ciliary neurotrophic factor-mediated signaling pathway;GO:0019221|cytokine-mediated signaling pathway;GO:0043524|negative regulation of neuron apoptotic process;GO:0007399|nervous system development;GO:0008284|positive regulation of cell proliferation;GO:0007548|sex differentiation;GO:0007165|signal transduction;GO:0060538|skeletal muscle organ development;GO:0001967|suckling behavior;","GO:0031225|anchored component of membrane;GO:0016324|apical plasma membrane;GO:0070110|ciliary neurotrophic factor receptor complex;GO:0097059|CNTFR-CLCF1 complex;GO:0019898|extrinsic component of membrane;GO:0005886|plasma membrane;","GO:0004897|ciliary neurotrophic factor receptor activity;GO:0019955|cytokine binding;GO:0005102|receptor binding;","K05059","CNTFR; ciliary neurotrophic factor receptor"]
["gene11632",4898,7867,5783,5630.77200349767,2198,2687,2579,2738.58693942192,2.05608663447663,1.03990105465657,{"v":6.05717121433012e-05,"d":"6.06E-05"},0.00191805939973421,"up","yes","WNK2","protein_coding","chrNC_037335.1:84552362-84699277:+","gi|528959623|ref|XP_002689895.3|",7973,0,"PREDICTED: serine/threonine-protein kinase WNK2 isoform X1 [Bos taurus]","gi|982986716|ref|XM_582977.9|",6883,0,"PREDICTED: Bos taurus WNK lysine deficient protein kinase 2 (WNK2), transcript variant X1, mRNA","Q3UH66",2247,0,"Serine/threonine-protein kinase WNK2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0050801|ion homeostasis;GO:0008285|negative regulation of cell proliferation;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:2000651|positive regulation of sodium ion transmembrane transporter activity;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0004674|protein serine/threonine kinase activity;","K08867","WNK, PRKWNK; WNK lysine deficient protein kinase [EC:2.7.11.1]"]
["gene11664",1442,1156,2077,1392.55197768466,291,194,270,277.424782510129,5.01956589849292,2.3275626025881,{"v":5.50970895747492e-17,"d":"5.51E-17"},{"v":2.56254456691844e-14,"d":"2.56E-14"},"up","yes","GADD45G","protein_coding","chrNC_037335.1:88508019-88509569:-","gi|114052512|ref|NP_001039366.1|",833,{"v":1e-108,"d":"1.00E-108"},"growth arrest and DNA damage-inducible protein GADD45 gamma [Bos taurus]","gi|742143287|ref|XM_010844790.1|",1077,0,"PREDICTED: Bison bison bison growth arrest and DNA-damage-inducible, gamma (GADD45G), mRNA","Q2KIX1",325,{"v":4e-110,"d":"4.00E-110"},"Growth arrest and DNA damage-inducible protein GADD45 gamma",".",".",".",".","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.","GO:0000185|activation of MAPKKK activity;GO:0006915|apoptotic process;GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0043065|positive regulation of apoptotic process;GO:0046330|positive regulation of JNK cascade;GO:1900745|positive regulation of p38MAPK cascade;GO:0051726|regulation of cell cycle;GO:0006950|response to stress;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".","K04402","GADD45; growth arrest and DNA-damage-inducible protein"]
["gene1172",0,105,0,34.4103563166921,0,0,0,0,"Inf","Inf",{"v":6.20023633983235e-10,"d":"6.20E-10"},{"v":8.75737341642361e-08,"d":"8.76E-08"},"up","yes","LCA5L","protein_coding","chrNC_037328.1:139470604-139512514:-","gi|594061460|ref|XP_006054810.1|",3372,0,"PREDICTED: lebercilin-like protein isoform X1 [Bubalus bubalis]","gi|594061463|ref|XM_006054750.1|",2229,0,"PREDICTED: Bubalus bubalis Leber congenital amaurosis 5-like (LCA5L), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam15619","Lebercilin","Ciliary protein causing Leber congenital amaurosis disease. Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.",".",".",".",".","."]
["gene11752",1,47,1,15.9704757931541,0,2,1,1.09494802643213,14.5856016976382,3.86647299763311,0.000866921021000047,0.0161872536977437,"up","yes","ACTL7B","protein_coding","chrNC_037335.1:98462724-98464130:-","gi|115496714|ref|NP_001069165.1|",2134,0,"actin-like protein 7B [Bos taurus]","gi|115496713|ref|NM_001075697.1|",1407,0,"Bos taurus actin like 7B (ACTL7B), mRNA","Q32L91",826,0,"Actin-like protein 7B","YFL039c",301,{"v":2e-96,"d":"2.00E-96"},"COG5277","pfam00022","Actin","Actin.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;",".",".","."]
["gene11753",0,26,0,8.52065965937138,0,0,0,0,"Inf","Inf",0.00158424756113207,0.0259771075670454,"up","yes","ACTL7A","protein_coding","chrNC_037335.1:98466288-98467808:+","gi|84370183|ref|NP_001033659.1|",2294,0,"actin-like protein 7A [Bos taurus]","gi|84370182|ref|NM_001038570.1|",1518,0,"Bos taurus actin like 7A (ACTL7A), mRNA","Q32KZ2",888,0,"Actin-like protein 7A","SPBC32H8.12c",320,{"v":2e-103,"d":"2.00E-103"},"COG5277","pfam00022","Actin","Actin.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005794|Golgi apparatus;GO:0001673|male germ cell nucleus;GO:0031514|motile cilium;GO:0032991|macromolecular complex;",".",".","."]
["gene11824",309,1193,739,698.46265871224,123,255,186,206.696262437352,3.37917411024274,1.75667068655158,0.000252994823427875,0.00606571034220226,"up","yes","HDHD3","protein_coding","chrNC_037335.1:102631185-102634313:-","gi|62460484|ref|NP_001014896.1|",1305,{"v":7e-176,"d":"7.00E-176"},"haloacid dehalogenase-like hydrolase domain-containing protein 3 [Bos taurus]","gi|62460483|ref|NM_001014896.1|",1603,0,"Bos taurus haloacid dehalogenase like hydrolase domain containing 3 (HDHD3), mRNA","Q5E9D6",507,{"v":2e-177,"d":"2.00E-177"},"Haloacid dehalogenase-like hydrolase domain-containing protein 3","alr4095",103,{"v":4e-24,"d":"4.00E-24"},"COG1011","pfam13419","HAD_2","Haloacid dehalogenase-like hydrolase.","GO:0008152|metabolic process;",".","GO:0016787|hydrolase activity;",".","."]
["gene11863",155,327,317,244.917840663937,106,109,110,119.328080309304,2.05247448906492,1.03736429034498,0.00226483974452616,0.0336377630146152,"up","yes","TRIM32","protein_coding","chrNC_037335.1:105876076-105887775:+","gi|115496330|ref|NP_001069292.1|",3296,0,"E3 ubiquitin-protein ligase TRIM32 [Bos taurus]","gi|741937118|ref|XM_005210578.2|",3185,0,"PREDICTED: Bos taurus tripartite motif containing 32 (TRIM32), transcript variant X4, mRNA","Q13049",1196,0,"E3 ubiquitin-protein ligase TRIM32",".",".",".",".","pfam13445","zf-RING_UBOX","RING-type zinc-finger. This zinc-finger is a typical RING-type of plant ubiquitin ligases.","GO:0007014|actin ubiquitination;GO:0061564|axon development;GO:0045444|fat cell differentiation;GO:0045087|innate immune response;GO:0046716|muscle cell cellular homeostasis;GO:0048147|negative regulation of fibroblast proliferation;GO:1902230|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:1902187|negative regulation of viral release from host cell;GO:0032897|negative regulation of viral transcription;GO:0045787|positive regulation of cell cycle;GO:0030307|positive regulation of cell growth;GO:0030335|positive regulation of cell migration;GO:2000147|positive regulation of cell motility;GO:1903886|positive regulation of chemokine (C-C motif) ligand 20 production;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:1903883|positive regulation of interleukin-17-mediated signaling pathway;GO:0050769|positive regulation of neurogenesis;GO:0045666|positive regulation of neuron differentiation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0045732|positive regulation of protein catabolic process;GO:0045862|positive regulation of proteolysis;GO:0051155|positive regulation of striated muscle cell differentiation;GO:1903265|positive regulation of tumor necrosis factor-mediated signaling pathway;GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0032479|regulation of type I interferon production;GO:0034612|response to tumor necrosis factor;GO:0009411|response to UV;GO:0001894|tissue homeostasis;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;GO:0005863|striated muscle myosin thick filament;","GO:0042802|identical protein binding;GO:0017022|myosin binding;GO:0043621|protein self-association;GO:0003723|RNA binding;GO:0030957|Tat protein binding;GO:0003713|transcription coactivator activity;GO:0031369|translation initiation factor binding;GO:0043130|ubiquitin binding;GO:0061630|ubiquitin protein ligase activity;GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K10607","TRIM32, HT2A; tripartite motif-containing protein 32 [EC:2.3.2.27]"]
["gene12076",66,2,3,18.7779338904274,2,1,0,1.11452374935921,16.8483927787305,4.07453906963295,0.00020225611657719,0.00511575289190054,"up","yes","TPD52L1","protein_coding","chrNC_037336.1:25985760-26078941:-","gi|555956059|ref|XP_005890182.1|",1088,{"v":3e-143,"d":"3.00E-143"},"PREDICTED: tumor protein D53 [Bos mutus]","gi|115496771|ref|NM_001076033.1|",1463,0,"Bos taurus tumor protein D52-like 1 (TPD52L1), mRNA","Q16890",313,{"v":8e-103,"d":"8.00E-103"},"Tumor protein D53",".",".",".",".","pfam04201","TPD52","tumor protein D52 family. The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologues from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologues of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.","GO:0000086|G2/M transition of mitotic cell cycle;GO:2001235|positive regulation of apoptotic signaling pathway;GO:0046330|positive regulation of JNK cascade;GO:0043406|positive regulation of MAP kinase activity;","GO:0005737|cytoplasm;GO:0048471|perinuclear region of cytoplasm;","GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;",".","."]
["gene12117",39,196,153,121.386581303144,32,42,59,48.6714572022142,2.49399932282327,1.31846107344358,0.0023121393143597,0.0342438961968542,"up","yes","FAM184A","protein_coding","chrNC_037336.1:31953230-32076963:+","gi|803290175|ref|XP_012004756.1|",4699,0,"PREDICTED: protein FAM184A isoform X5 [Ovis aries musimon]","gi|982987463|ref|XM_015464768.1|",5548,0,"PREDICTED: Bos taurus family with sequence similarity 184 member A (FAM184A), transcript variant X8, mRNA","Q8NB25",1694,0,"Protein FAM184A",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.",".","GO:0005615|extracellular space;",".",".","."]
["gene12185",16840,5247,6665,8155.39565911679,2794,4418,3293,3854.34284544846,2.11589782905466,1.08126996531824,0.00104700433134127,0.0187168424671039,"up","yes","REV3L","protein_coding","chrNC_037336.1:38930128-39108208:+","gi|329663970|ref|NP_001193101.1|",15961,0,"DNA polymerase zeta catalytic subunit [Bos taurus]","gi|982934925|ref|XM_015472806.1|",10393,0,"PREDICTED: Bos taurus REV3 like, DNA directed polymerase zeta catalytic subunit (REV3L), transcript variant X1, mRNA","O60673",5560,0,"DNA polymerase zeta catalytic subunit","YPL167c",619,0,"COG0417","pfam00136","DNA_pol_B","DNA polymerase family B. This region of DNA polymerase B appears to consist of more than one structural domain, possibly including elongation, DNA-binding and dNTP binding activities.","GO:0006261|DNA-dependent DNA replication;GO:0042276|error-prone translesion synthesis;","GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0016035|zeta DNA polymerase complex;","GO:0051539|4 iron, 4 sulfur cluster binding;GO:0003677|DNA binding;GO:0003887|DNA-directed DNA polymerase activity;GO:0046872|metal ion binding;GO:0000166|nucleotide binding;","K02350","POLZ1, rev3; DNA polymerase zeta [EC:2.7.7.7]"]
["gene12257",4306,4954,5985,4583.88001775067,1297,2311,1580,1903.22264866052,2.40848332746396,1.26812493701672,0.00083549005660684,0.0157967970875081,"up","yes","BVES","protein_coding","chrNC_037336.1:44880414-44931248:+","gi|528909326|ref|XP_590718.4|",1723,0,"PREDICTED: blood vessel epicardial substance isoform X1 [Bos taurus]","gi|982987604|ref|XM_005199388.3|",4808,0,"PREDICTED: Bos taurus blood vessel epicardial substance (BVES), transcript variant X2, mRNA","B8Q0B2",610,0,"Blood vessel epicardial substance",".",".",".",".","pfam04831","Popeye","Popeye protein conserved region. The function of Popeye proteins is not well understood. They are predominantly expressed in cardiac and skeletal muscle. This family represents a conserved region which includes three potential transmembrane domains.","GO:0090136|epithelial cell-cell adhesion;GO:0007507|heart development;GO:0040017|positive regulation of locomotion;GO:0001921|positive regulation of receptor recycling;GO:0008360|regulation of cell shape;GO:0043087|regulation of GTPase activity;GO:0002931|response to ischemia;GO:0007519|skeletal muscle tissue development;GO:0034446|substrate adhesion-dependent cell spreading;GO:0016192|vesicle-mediated transport;","GO:0005923|bicellular tight junction;GO:0005901|caveola;GO:0016021|integral component of membrane;GO:0016328|lateral plasma membrane;GO:0005886|plasma membrane;GO:0042383|sarcolemma;","GO:0030552|cAMP binding;GO:0005198|structural molecule activity;",".","."]
["gene1226",2161,1761,1529,1609.90662567265,407,426,389,448.878770703062,3.58650649294711,1.84257924260232,{"v":1.23612613739475e-13,"d":"1.24E-13"},{"v":3.45763870843232e-11,"d":"3.46E-11"},"up","yes","PDXK","protein_coding","chrNC_037328.1:143782398-143813208:+","gi|115497140|ref|NP_001069119.1|",1511,0,"pyridoxal kinase [Bos taurus]","gi|926684292|ref|XM_013966831.1|",2022,0,"PREDICTED: Capra hircus pyridoxal (pyridoxine, vitamin B6) kinase (PDXK), mRNA","Q0II59",586,0,"Pyridoxal kinase","SPAC6F6.11c",157,{"v":2e-40,"d":"2.00E-40"},"COG2240","pfam00294","PfkB","pfkB family carbohydrate kinase. This family includes a variety of carbohydrate and pyrimidine kinases.","GO:0008283|cell proliferation;GO:0009443|pyridoxal 5'-phosphate salvage;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0005524|ATP binding;GO:0031403|lithium ion binding;GO:0000287|magnesium ion binding;GO:0030955|potassium ion binding;GO:0042803|protein homodimerization activity;GO:0008478|pyridoxal kinase activity;GO:0030170|pyridoxal phosphate binding;GO:0031402|sodium ion binding;GO:0008270|zinc ion binding;","K00868","pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35]"]
["gene12279",145,5,99,69.8339994644857,14,16,29,21.5727681315635,3.23713670116865,1.69471829045714,0.00123755198913619,0.0214251188119203,"up","yes","SIM1","protein_coding","chrNC_037336.1:49486349-49554234:+","gi|555981519|ref|XP_005902674.1|",3957,0,"PREDICTED: single-minded homolog 1 [Bos mutus]","gi|300794522|ref|NM_001192972.1|",2301,0,"Bos taurus single-minded homolog 1 (Drosophila) (SIM1), mRNA","P81133",1489,0,"Single-minded homolog 1",".",".",".",".","pfam06621","SIM_C","Single-minded protein C-terminus. This family represents the C-terminal region of the eukaryotic single-minded (SIM) protein. Drosophila single-minded acts as a positive master gene regulator in central nervous system midline formation. There are two homologues in mammals: SIM1 and SIM2, which are members of the basic-helix-loop-helix PAS family of transcription factors. SIM1 and SIM2 are novel heterodimerization partners for ARNT in vitro, and they may function both as positive and negative transcriptional regulators in vivo, during embryogenesis and in the adult organism. SIM2 is thought to contribute to some specific Down syndrome phenotypes. This family is found in conjunction with a pfam00989 domain and associated pfam00785 motif.","GO:0030154|cell differentiation;GO:0007399|nervous system development;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;GO:0001657|ureteric bud development;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09100","SIM; single-minded"]
["gene12290",4321,552,812,1556.43593178109,592,663,557,665.645366497909,2.33823595884067,1.22542052416916,{"v":3.60696830710866e-06,"d":"3.61E-06"},0.000177645536414745,"up","yes","PNISR","protein_coding","chrNC_037336.1:50369882-50375033:+","gi|936626783|gb|ALH22614.1|",650,{"v":3e-71,"d":"3.00E-71"},"splicing factor arginine/serine-rich 18 [Capra hircus]","gi|118151263|ref|NM_001078097.1|",3870,0,"Bos taurus PNN-interacting serine/arginine-rich protein (PNISR), mRNA","Q8TF01",189,{"v":4e-48,"d":"4.00E-48"},"Arginine/serine-rich protein PNISR",".",".",".",".","pfam11600","CAF-1_p150","Chromatin assembly factor 1 complex p150 subunit, N-terminal. CAF-1_p150 is a polypeptide subunit of CAF-1, which functions in depositing newly synthesized and acetylated histones H3/H4 into chromatin during DNA replication and repair. CAF-1_p150 includes the HP1 interaction site, the PEST, KER and ED interacting sites. CAF-1_p150 interacts directly with newly synthesized and acetylated histones through the acidic KER and ED domains. The PEST domain is associated with proteins that undergo rapid proteolysis.",".","GO:0005829|cytosol;GO:0016607|nuclear speck;","GO:0003723|RNA binding;","K13170","SFRS18; splicing factor, arginine/serine-rich 18"]
["gene12310",1339,72,188,430.309054144885,81,72,99,92.4346362290865,4.65527935955114,2.21886774534498,{"v":4.5674738796366e-12,"d":"4.57E-12"},{"v":9.94767918014594e-10,"d":"9.95E-10"},"up","yes","FHL5","protein_coding","chrNC_037336.1:53181874-53239359:-","gi|115496932|ref|NP_001069847.1|",1494,0,"four and a half LIM domains protein 5 [Bos taurus]","gi|982935075|ref|XM_010808492.2|",5391,0,"PREDICTED: Bos taurus four and a half LIM domains 5 (FHL5), transcript variant X1, mRNA","Q2YDK0",580,0,"Four and a half LIM domains protein 5",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0045944|positive regulation of transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0003713|transcription coactivator activity;",".","."]
["gene12329",410,532,694,494.343746164776,157,161,183,183.824627353271,2.68921391699467,1.42718452081598,{"v":1.01453852258286e-06,"d":"1.01E-06"},{"v":6.18499969825036e-05,"d":"6.18E-05"},"up","yes","BACH2","protein_coding","chrNC_037336.1:59951496-60344970:+","gi|742096103|ref|XP_010833019.1|",3953,0,"PREDICTED: transcription regulator protein BACH2 isoform X1 [Bison bison bison]","gi|982987658|ref|XM_010798923.2|",4385,0,"PREDICTED: Bos taurus BTB and CNC homology 1, basic leucine zipper transcription factor 2 (BACH2), transcript variant X2, mRNA","Q9BYV9",1433,0,"Transcription regulator protein BACH2",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0051170|nuclear import;GO:0016567|protein ubiquitination;GO:0006366|transcription from RNA polymerase II promoter;","GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001206|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;","K09042","BACH; transcription regulator BACH"]
["gene12337",526,699,946,656.699545734519,112,197,163,172.997158009506,3.79601349114899,1.92448511975079,{"v":3.48748726894983e-08,"d":"3.49E-08"},{"v":3.31671664234692e-06,"d":"3.32E-06"},"up","yes","ANKRD6","protein_coding","chrNC_037336.1:60560036-60742895:-","gi|741937872|ref|XP_010806798.1|",3571,0,"PREDICTED: ankyrin repeat domain-containing protein 6 isoform X2 [Bos taurus]","gi|982935082|ref|XM_015472834.1|",3980,0,"PREDICTED: Bos taurus ankyrin repeat domain 6 (ANKRD6), transcript variant X3, mRNA","Q9Y2G4",1255,0,"Ankyrin repeat domain-containing protein 6","all2748",123,{"v":1e-28,"d":"1.00E-28"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0046330|positive regulation of JNK cascade;GO:2000096|positive regulation of Wnt signaling pathway, planar cell polarity pathway;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;GO:0005634|nucleus;",".",".","."]
["gene12463",2419,136,137,717.092878083202,147,198,184,194.026459392484,3.69585096964862,1.88590658313824,{"v":6.37958253300535e-11,"d":"6.38E-11"},{"v":1.10312648029803e-08,"d":"1.10E-08"},"up","yes","VNN1","protein_coding","chrNC_037336.1:70835457-70854106:-","gi|440912692|gb|ELR62240.1|",2765,0,"Pantetheinase [Bos mutus]","gi|594070976|ref|XM_006059301.1|",1645,0,"PREDICTED: Bubalus bubalis vanin 1 (VNN1), transcript variant X1, mRNA","Q58CQ9",1041,0,"Pantetheinase","PAB1449",73.6,{"v":2e-13,"d":"2.00E-13"},"COG0388","pfam00795","CN_hydrolase","Carbon-nitrogen hydrolase. This family contains hydrolases that break carbon-nitrogen bonds. The family includes: Nitrilase EC:3.5.5.1, Aliphatic amidase EC:3.5.1.4, Biotidinase EC:3.5.1.12, Beta-ureidopropionase EC:3.5.1.6. Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins.","GO:0015939|pantothenate metabolic process;","GO:0031225|anchored component of membrane;GO:0005886|plasma membrane;","GO:0017159|pantetheine hydrolase activity;","K08069","VNN; pantetheine hydrolase [EC:3.5.1.92]"]
["gene12467",503,47,124,184.579301618729,36,49,32,42.9891745576423,4.2936228368664,2.10219546663201,{"v":1.09965277636981e-07,"d":"1.10E-07"},{"v":9.17374074930033e-06,"d":"9.17E-06"},"up","yes","VNN2","protein_coding","chrNC_037336.1:70886776-70916016:-","gi|742141235|ref|XP_010842586.1|",2740,0,"PREDICTED: vascular non-inflammatory molecule 2 isoform X1 [Bison bison bison]","gi|942032763|ref|XM_005887737.2|",1941,0,"PREDICTED: Bos mutus vascular non-inflammatory molecule 2 (LOC102269960), transcript variant X2, mRNA","O95498",858,0,"Vascular non-inflammatory molecule 2","PAB1449",76.6,{"v":1e-14,"d":"1.00E-14"},"COG0388","pfam00795","CN_hydrolase","Carbon-nitrogen hydrolase. This family contains hydrolases that break carbon-nitrogen bonds. The family includes: Nitrilase EC:3.5.5.1, Aliphatic amidase EC:3.5.1.4, Biotidinase EC:3.5.1.12, Beta-ureidopropionase EC:3.5.1.6. Nitrilase-related proteins generally have a conserved E-K-C catalytic triad, and are multimeric alpha-beta-beta-alpha sandwich proteins.","GO:0015939|pantothenate metabolic process;","GO:0031225|anchored component of membrane;GO:0005576|extracellular region;GO:0005886|plasma membrane;","GO:0017159|pantetheine hydrolase activity;","K08069","VNN; pantetheine hydrolase [EC:3.5.1.92]"]
["gene12553",10103,9722,10639,9086.61489895932,3354,4699,3938,4399.60399589037,2.0653256309993,1.0463692630933,{"v":9.35287556994887e-05,"d":"9.35E-05"},0.00275953353553476,"up","yes","HIVEP2","protein_coding","chrNC_037336.1:80195042-80415334:-","gi|528961171|ref|XP_005211057.1|",11308,0,"PREDICTED: transcription factor HIVEP2 [Bos taurus]","gi|982987972|ref|XM_015464844.1|",9795,0,"PREDICTED: Bos taurus human immunodeficiency virus type I enhancer binding protein 2 (HIVEP2), transcript variant X1, mRNA","P31629",3930,0,"Transcription factor HIVEP2",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.","GO:0007275|multicellular organismal development;GO:0006355|regulation of transcription, DNA-templated;GO:0007165|signal transduction;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0044212|transcription regulatory region DNA binding;","K09239","HIVEP; human immunodeficiency virus type I enhancer-binding protein"]
["gene12640",2070,4943,3768,3316.63290400447,1016,1099,1086,1175.08427480746,2.82246386502611,1.49695511081888,{"v":4.64826303774984e-09,"d":"4.65E-09"},{"v":5.24471651540594e-07,"d":"5.24E-07"},"up","yes","ESR1","protein_coding","chrNC_037336.1:88683050-89098471:+","gi|47824866|ref|NP_001001443.1|",2764,0,"estrogen receptor [Bos taurus]","gi|965846086|ref|XM_012137954.2|",4917,0,"PREDICTED: Ovis aries musimon estrogen receptor 1 (ESR1), transcript variant X5, mRNA","P49884",1069,0,"Estrogen receptor",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0071392|cellular response to estradiol stimulus;GO:0030518|intracellular steroid hormone receptor signaling pathway;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0007200|phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0010863|positive regulation of phospholipase C activity;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005794|Golgi apparatus;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0030284|estrogen receptor activity;GO:0043565|sequence-specific DNA binding;GO:0005496|steroid binding;GO:0008270|zinc ion binding;","K08550","NR3A1, ESR1; estrogen receptor alpha"]
["gene12678",241,253,253,223.424546219644,75,94,74,89.2414319944139,2.50359660559491,1.32400212537321,0.000142206497253544,0.00390124382032776,"up","yes","ZDHHC14","protein_coding","chrNC_037336.1:94011749-94302733:+","gi|742123689|ref|XP_010839171.1|",2394,0,"PREDICTED: probable palmitoyltransferase ZDHHC14 isoform X1 [Bison bison bison]","gi|742123688|ref|XM_010840869.1|",2372,0,"PREDICTED: Bison bison bison zinc finger, DHHC-type containing 14 (ZDHHC14), transcript variant X1, mRNA","Q8IZN3",855,0,"Probable palmitoyltransferase ZDHHC14","SPBC3H7.09",152,{"v":3e-39,"d":"3.00E-39"},"COG5273","pfam01529","zf-DHHC","DHHC palmitoyltransferase. This family includes the well known DHHC zinc binding domain as well as three of the four conserved transmembrane regions found in this family of palmitoyltransferase enzymes.","GO:0018345|protein palmitoylation;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;","GO:0016409|palmitoyltransferase activity;GO:0019706|protein-cysteine S-palmitoyltransferase activity;","K16675","ZDHHC9_14_18; palmitoyltransferase ZDHHC9/14/18 [EC:2.3.1.225]"]
["gene12680",5199,866,921,1921.64274305743,333,188,264,288.755279553238,6.65491812316157,2.73442091646993,{"v":1.13573609662763e-11,"d":"1.14E-11"},{"v":2.18943828195156e-09,"d":"2.19E-09"},"up","yes","SYNJ2","protein_coding","chrNC_037336.1:94544408-94655538:+","gi|528909644|ref|XP_596626.5|",5702,0,"PREDICTED: synaptojanin-2 isoform X1 [Bos taurus]","gi|982988157|ref|XM_015464876.1|",6581,0,"PREDICTED: Bos taurus synaptojanin 2 (SYNJ2), transcript variant X6, mRNA","O15056",1807,0,"Synaptojanin-2","SPBC2G2.02_2",253,{"v":3e-70,"d":"3.00E-70"},"COG5411","pfam08952","DUF1866","Domain of unknown function (DUF1866). This domain, found in Synaptojanin, has no known function.","GO:0061024|membrane organization;GO:0006661|phosphatidylinositol biosynthetic process;GO:0046856|phosphatidylinositol dephosphorylation;","GO:0030424|axon;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0045121|membrane raft;GO:0005886|plasma membrane;","GO:0034596|phosphatidylinositol phosphate 4-phosphatase activity;GO:0052629|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0043813|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity;GO:0004438|phosphatidylinositol-3-phosphatase activity;GO:0004439|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0003723|RNA binding;",".","."]
["gene12689",1116,1300,1398,1146.24455906191,378,562,451,510.330124554366,2.24608445378928,1.1674121747431,{"v":1.43290805715445e-05,"d":"1.43E-05"},0.000579069401964214,"up","yes","DYNLT1","protein_coding","chrNC_037336.1:95047826-95055238:-","gi|743739270|ref|XP_010964062.1|",635,{"v":1e-80,"d":"1.00E-80"},"PREDICTED: dynein light chain Tctex-type 1 [Camelus bactrianus]","gi|79158750|gb|BC108160.1|",732,0,"Bos taurus TCTEL1 protein, mRNA (cDNA clone MGC:134363 IMAGE:8057994), complete cds","P63172",236,{"v":2e-77,"d":"2.00E-77"},"Dynein light chain Tctex-type 1",".",".",".",".","pfam03645","Tctex-1","Tctex-1 family. Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.","GO:0051301|cell division;GO:0000132|establishment of mitotic spindle orientation;GO:0019060|intracellular transport of viral protein in host cell;GO:0075521|microtubule-dependent intracellular transport of viral material towards nucleus;GO:0050768|negative regulation of neurogenesis;GO:0043312|neutrophil degranulation;GO:0008277|regulation of G-protein coupled receptor protein signaling pathway;GO:0046718|viral entry into host cell;","GO:0005868|cytoplasmic dynein complex;GO:0005881|cytoplasmic microtubule;GO:0005576|extracellular region;GO:0005794|Golgi apparatus;GO:0043657|host cell;GO:0034774|secretory granule lumen;GO:0005819|spindle;","GO:0042802|identical protein binding;GO:0003774|motor activity;","K10420","DYNLT; dynein light chain Tctex-type 1"]
["gene1272",76,175,74,99.8849607477051,16,24,25,23.8123133100358,4.19467690716164,2.06855969209854,{"v":1.22175538554873e-05,"d":"1.22E-05"},0.000507393055387057,"up","yes","PCBP3","protein_coding","chrNC_037328.1:145395840-145625230:+","gi|741915565|ref|XP_010800006.1|",1999,0,"PREDICTED: poly(rC)-binding protein 3 isoform X1 [Bos taurus]","gi|982912500|ref|XM_010801704.2|",2245,0,"PREDICTED: Bos taurus poly(rC) binding protein 3 (PCBP3), transcript variant X1, mRNA","P57722",690,0,"Poly(rC)-binding protein 3",".",".",".",".","pfam00013","KH_1","KH domain. KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.","GO:0000122|negative regulation of transcription from RNA polymerase II promoter;","GO:0005737|cytoplasm;","GO:1990829|C-rich single-stranded DNA binding;GO:0003690|double-stranded DNA binding;GO:0003723|RNA binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;",".","."]
["gene1275",13226,13616,16854,13085.4348633036,4907,3958,4975,5082.45693665232,2.57462778856767,1.36436387835348,{"v":7.68846877427624e-07,"d":"7.69E-07"},{"v":4.82975840979893e-05,"d":"4.83E-05"},"up","yes","COL6A1","protein_coding","chrNC_037328.1:145668730-145687976:+","gi|219804724|ref|NP_001137337.1|",4186,0,"collagen alpha-1(VI) chain precursor [Bos taurus]","gi|219804723|ref|NM_001143865.1|",4066,0,"Bos taurus collagen type VI alpha 1 (COL6A1), mRNA","Q04857",1484,0,"Collagen alpha-1(VI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0007155|cell adhesion;GO:0071230|cellular response to amino acid stimulus;GO:0035987|endodermal cell differentiation;GO:0070208|protein heterotrimerization;","GO:0005581|collagen trimer;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0032991|macromolecular complex;GO:0042383|sarcolemma;","GO:0048407|platelet-derived growth factor binding;","K06238","COL6A; collagen, type VI, alpha"]
["gene1276",13707,16399,21461,15537.7423074863,6116,4173,5756,5895.16471090056,2.6356756883749,1.39817286216774,{"v":7.84547125569171e-07,"d":"7.85E-07"},{"v":4.89801182486084e-05,"d":"4.90E-05"},"up","yes","COL6A2","protein_coding","chrNC_037328.1:145807051-145838162:+","gi|741915482|ref|XP_010799975.1|",3363,0,"PREDICTED: collagen alpha-2(VI) chain isoform X2 [Bos taurus]","gi|982912397|ref|XM_010801673.2|",2880,0,"PREDICTED: Bos taurus collagen type VI alpha 2 (COL6A2), transcript variant X2, mRNA","P12110",1163,0,"Collagen alpha-2(VI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0007155|cell adhesion;GO:0030198|extracellular matrix organization;GO:0070208|protein heterotrimerization;GO:0009749|response to glucose;","GO:0005581|collagen trimer;GO:0005788|endoplasmic reticulum lumen;GO:0070062|extracellular exosome;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:1903561|extracellular vesicle;GO:0032991|macromolecular complex;GO:0042383|sarcolemma;",".","K06238","COL6A; collagen, type VI, alpha"]
["gene12793",403,166,198,220.242382647692,79,94,90,96.5120705704054,2.28201904016788,1.19031082889267,0.000516827886641719,0.0108105692329728,"up","yes","DLL1","protein_coding","chrNC_037336.1:103921805-103932473:-","gi|741938875|ref|XP_010807105.1|",3628,0,"PREDICTED: delta-like protein 1 [Bos taurus]","gi|982988415|ref|XM_015464935.1|",4544,0,"PREDICTED: Bos taurus delta-like 1 (Drosophila) (DLL1), mRNA","O00548",1233,0,"Delta-like protein 1",".",".",".",".","pfam07657","MNNL","N terminus of Notch ligand. This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins.","GO:0014002|astrocyte development;GO:0030154|cell differentiation;GO:0001709|cell fate determination;GO:0021688|cerebellar molecular layer formation;GO:0021693|cerebellar Purkinje cell layer structural organization;GO:0072583|clathrin-mediated endocytosis;GO:0007386|compartment pattern specification;GO:0007368|determination of left/right symmetry;GO:0097102|endothelial tip cell fate specification;GO:0097009|energy homeostasis;GO:0001947|heart looping;GO:0030097|hemopoiesis;GO:0048839|inner ear development;GO:0046331|lateral inhibition;GO:0070986|left/right axis specification;GO:0072070|loop of Henle development;GO:0002315|marginal zone B cell differentiation;GO:2000726|negative regulation of cardiac muscle cell differentiation;GO:0045596|negative regulation of cell differentiation;GO:0008285|negative regulation of cell proliferation;GO:0045605|negative regulation of epidermal cell differentiation;GO:0030857|negative regulation of epithelial cell differentiation;GO:0034351|negative regulation of glial cell apoptotic process;GO:0045608|negative regulation of auditory receptor cell differentiation;GO:0032693|negative regulation of interleukin-10 production;GO:0045638|negative regulation of myeloid cell differentiation;GO:0045662|negative regulation of myoblast differentiation;GO:0045665|negative regulation of neuron differentiation;GO:0072006|nephron development;GO:0048665|neuron fate specification;GO:0097150|neuronal stem cell population maintenance;GO:0007219|Notch signaling pathway;GO:0060853|Notch signaling pathway involved in arterial endothelial cell fate commitment;GO:0035265|organ growth;GO:0008284|positive regulation of cell proliferation;GO:0045807|positive regulation of endocytosis;GO:0045747|positive regulation of Notch signaling pathway;GO:0048633|positive regulation of skeletal muscle tissue growth;GO:1903672|positive regulation of sprouting angiogenesis;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0072014|proximal tubule development;GO:0009954|proximal/distal pattern formation;GO:0008217|regulation of blood pressure;GO:0030155|regulation of cell adhesion;GO:0051302|regulation of cell division;GO:0040008|regulation of growth;GO:0050767|regulation of neurogenesis;GO:0048631|regulation of skeletal muscle tissue growth;GO:0014807|regulation of somitogenesis;GO:1900746|regulation of vascular endothelial growth factor signaling pathway;GO:0060041|retina development in camera-type eye;GO:0060042|retina morphogenesis in camera-type eye;GO:0048630|skeletal muscle tissue growth;GO:0098773|skin epidermis development;GO:0001757|somite specification;GO:0001756|somitogenesis;GO:0021510|spinal cord development;GO:0003323|type B pancreatic cell development;","GO:0005912|adherens junction;GO:0016324|apical plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0005112|Notch binding;GO:0097110|scaffold protein binding;GO:0030957|Tat protein binding;","K06051","DLL; delta"]
["gene12824",5947,5492,9248,6190.01275127528,2131,1510,1860,2022.06060188108,3.06123997743531,1.61411614538279,{"v":1.57056637794158e-10,"d":"1.57E-10"},{"v":2.45012518799209e-08,"d":"2.45E-08"},"up","yes","NREP","protein_coding","chrNC_037337.1:2212319-2245527:+","gi|602731729|ref|XP_007451266.1|",403,{"v":3e-43,"d":"3.00E-43"},"PREDICTED: neuronal regeneration-related protein-like [Lipotes vexillifer]","gi|157279998|ref|NM_001105045.1|",1938,0,"Bos taurus neuronal regeneration related protein (NREP), mRNA","Q5NVD3",117,{"v":1e-29,"d":"1.00E-29"},"Neuronal regeneration-related protein",".",".",".",".","pfam11092","Alveol-reg_P311","Neuronal protein 3.1 (p311). P311 has several PEST-like motifs and is found in neuron and muscle cells. P311 could have some function in myo-fibroblast transformation and prevention of fibrosis. It has also been identified as a potential regulator of alveolar generation.",".","GO:0005737|cytoplasm;",".",".","."]
["gene12859",746,1213,1542,1065.5280385811,80,61,80,81.1655199994062,13.1278409673084,3.7145577619271,{"v":1.93073977489948e-40,"d":"1.93E-40"},{"v":6.88574206470714e-37,"d":"6.89E-37"},"up","yes","HRH2","protein_coding","chrNC_037337.1:5450060-5500059:-","gi|528961781|ref|XP_005211286.1|",1957,0,"PREDICTED: histamine H2 receptor isoform X3 [Bos taurus]","gi|982988452|ref|XM_015464945.1|",2668,0,"PREDICTED: Bos taurus histamine receptor H2 (HRH2), transcript variant X5, mRNA","P17124",572,0,"Histamine H2 receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0001697|histamine-induced gastric acid secretion;GO:0006955|immune response;GO:0045907|positive regulation of vasoconstriction;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004969|histamine receptor activity;","K04150","HRH2; histamine receptor H2"]
["gene12917",142,208,187,162.605522390428,53,70,51,63.9084559201753,2.54435066610794,1.34729751865336,0.000426947318623919,0.00934143707642564,"up","yes","MTX3","protein_coding","chrNC_037337.1:10951634-10961474:-","gi|528910043|ref|XP_005193628.1|",1326,{"v":2e-178,"d":"2.00E-178"},"PREDICTED: metaxin-3 isoform X3 [Bos taurus]","gi|965944647|ref|XM_004010213.3|",1595,0,"PREDICTED: Ovis aries metaxin 3 (MTX3), transcript variant X5, mRNA","Q5HYI7",493,{"v":2e-170,"d":"2.00E-170"},"Metaxin-3",".",".",".",".","pfam11801","Tom37_C","Tom37 C-terminal domain. The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intramembrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex.","GO:0006626|protein targeting to mitochondrion;","GO:0005741|mitochondrial outer membrane;",".","K17776","MTX; metaxin"]
["gene12948",1145,3864,4364,2904.99352769749,626,521,656,661.977562724564,4.38835648105825,2.13368072550533,{"v":3.90800954843595e-17,"d":"3.91E-17"},{"v":1.92240380045562e-14,"d":"1.92E-14"},"up","yes","IGDCC4","protein_coding","chrNC_037337.1:12315309-12354667:-","gi|359069114|ref|XP_002690569.2|",6001,0,"PREDICTED: immunoglobulin superfamily DCC subclass member 4 isoform X1 [Bos taurus]","gi|982988544|ref|XM_015464960.1|",6302,0,"PREDICTED: Bos taurus immunoglobulin superfamily, DCC subclass, member 4 (IGDCC4), transcript variant X1, mRNA","Q8TDY8",2038,0,"Immunoglobulin superfamily DCC subclass member 4",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".",".","."]
["gene13014",1434,1345,1029,1130.54216113873,582,331,531,530.68251759178,2.13035501201187,1.09109386772393,0.0024204322375671,0.0353096323186114,"up","yes","TLE3","protein_coding","chrNC_037337.1:16922722-16971882:-","gi|440900345|gb|ELR51501.1|",3819,0,"Transducin-like enhancer protein 3, partial [Bos mutus]","gi|982936014|ref|XM_010808914.2|",5353,0,"PREDICTED: Bos taurus transducin like enhancer of split 3 (TLE3), transcript variant X1, mRNA","Q04726",1390,0,"Transducin-like enhancer protein 3",".",".",".",".","pfam03920","TLE_N","Groucho/TLE N-terminal Q-rich domain. The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.","GO:0009887|organ morphogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0007165|signal transduction;GO:0006351|transcription, DNA-templated;GO:0016055|Wnt signaling pathway;","GO:0005654|nucleoplasm;GO:0005634|nucleus;",".",".","."]
["gene13030",60382,146172,143542,107724.954423004,19168,31801,24063,27521.0490489475,3.91427500570236,1.96874511912911,{"v":9.86106275769233e-06,"d":"9.86E-06"},0.000425636885839213,"up","yes","PKM","protein_coding","chrNC_037337.1:19137913-19164576:-","gi|73587283|gb|AAI02827.1|",2886,0,"PKM2 protein [Bos taurus]","gi|741939199|ref|XR_809071.1|",2575,0,"PREDICTED: Bos taurus pyruvate kinase, muscle (PKM), transcript variant X2, misc_RNA","P14618",1057,0,"Pyruvate kinase PKM","SPAC4H3.10c",494,{"v":1e-164,"d":"1.00E-164"},"COG0469","pfam00224","PK","Pyruvate kinase, barrel domain. This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.","GO:0031100|organ regeneration;GO:0061621|canonical glycolysis;GO:0032869|cellular response to insulin stimulus;GO:0001889|liver development;GO:0043312|neutrophil degranulation;GO:0012501|programmed cell death;GO:0051289|protein homotetramerization;GO:0009629|response to gravity;GO:0001666|response to hypoxia;GO:0014870|response to muscle inactivity;GO:0007584|response to nutrient;GO:0043403|skeletal muscle tissue regeneration;","GO:0005929|cilium;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:1903561|extracellular vesicle;GO:0005739|mitochondrion;GO:0043209|myelin sheath;GO:0005634|nucleus;GO:0001917|photoreceptor inner segment;GO:1902912|pyruvate kinase complex;GO:0034774|secretory granule lumen;GO:0031982|vesicle;","GO:0043531|ADP binding;GO:0005524|ATP binding;GO:0045296|cadherin binding;GO:0042802|identical protein binding;GO:0016301|kinase activity;GO:0000287|magnesium ion binding;GO:0023026|MHC class II protein complex binding;GO:0030955|potassium ion binding;GO:0004743|pyruvate kinase activity;GO:0003723|RNA binding;GO:0070324|thyroid hormone binding;","K00873","PK, pyk; pyruvate kinase [EC:2.7.1.40]"]
["gene13041",2541,5357,3949,3630.65058342892,1132,1700,1366,1540.07331099847,2.35745308843451,1.23722906262624,{"v":1.32494646632596e-05,"d":"1.32E-05"},0.000542677005758366,"up","yes","NEO1","protein_coding","chrNC_037337.1:19888560-20128317:+","gi|741884106|ref|XP_010808326.1|",7320,0,"PREDICTED: neogenin isoform X2 [Bos taurus]","gi|982988664|ref|XM_010810024.2|",5215,0,"PREDICTED: Bos taurus neogenin 1 (NEO1), transcript variant X2, mRNA","Q92859",2642,0,"Neogenin",".",".",".",".","pfam06583","Neogenin_C","Neogenin C-terminus. This family represents the C-terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites. Neogenin is a member of the N-CAM family of cell adhesion molecules (and therefore contains multiple copies of pfam00047 and pfam00041) and is closely related to the DCC tumor suppressor gene product - these proteins may play an integral role in regulating differentiation programmes and/or cell migration events within many adult and embryonic tissues.","GO:0007411|axon guidance;GO:0007155|cell adhesion;GO:0055072|iron ion homeostasis;GO:0030513|positive regulation of BMP signaling pathway;","GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0098797|plasma membrane protein complex;","GO:0039706|co-receptor binding;GO:0038023|signaling receptor activity;","K06766","NEO1; neogenin"]
["gene13050",0,26,0,8.52065965937138,0,0,0,0,"Inf","Inf",0.00158424756113207,0.0259771075670454,"up","yes","TBC1D21","protein_coding","chrNC_037337.1:20690530-20704230:+","gi|578826661|ref|XP_006720472.1|",1821,0,"PREDICTED: TBC1 domain family member 21 isoform X1 [Homo sapiens]","gi|942098669|ref|XM_005910274.2|",1103,0,"PREDICTED: Bos mutus TBC1 domain family, member 21 (TBC1D21), transcript variant X1, mRNA","Q8IYX1",640,0,"TBC1 domain family member 21","SPAC630.05",101,{"v":9e-22,"d":"9.00E-22"},"COG5210","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0090630|activation of GTPase activity;GO:0030154|cell differentiation;GO:0006886|intracellular protein transport;GO:0031338|regulation of vesicle fusion;GO:0007283|spermatogenesis;","GO:0001669|acrosomal vesicle;GO:0005856|cytoskeleton;GO:0012505|endomembrane system;GO:0070062|extracellular exosome;GO:0005622|intracellular;","GO:0003779|actin binding;GO:0005096|GTPase activator activity;",".","."]
["gene13060",1900,219,359,677.210988200354,173,209,246,230.161612080276,2.94232814099405,1.5569581510746,{"v":7.7533503851285e-08,"d":"7.75E-08"},{"v":6.6230790370689e-06,"d":"6.62E-06"},"up","yes","ADCY4","protein_coding","chrNC_037337.1:20836833-20853209:+","gi|555997237|ref|XP_005910346.1|",5254,0,"PREDICTED: adenylate cyclase type 4 isoform X1 [Bos mutus]","gi|594075479|ref|XM_006061451.1|",4084,0,"PREDICTED: Bubalus bubalis adenylate cyclase 4 (ADCY4), transcript variant X2, mRNA","Q8NFM4",1908,0,"Adenylate cyclase type 4","all0661",157,{"v":3e-39,"d":"3.00E-39"},"COG2114","pfam00211","Guanylate_cyc","Adenylate and Guanylate cyclase catalytic domain.","GO:0007189|adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007193|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0007188|adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0006171|cAMP biosynthetic process;GO:0071377|cellular response to glucagon stimulus;GO:0006182|cGMP biosynthetic process;GO:0007186|G-protein coupled receptor signaling pathway;GO:0003091|renal water homeostasis;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0008074|guanylate cyclase complex, soluble;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0004016|adenylate cyclase activity;GO:0005524|ATP binding;GO:0004383|guanylate cyclase activity;GO:0046872|metal ion binding;GO:0005080|protein kinase C binding;","K08044","ADCY4; adenylate cyclase 4 [EC:4.6.1.1]"]
["gene13066",660,2062,1746,1383.99956311564,309,567,393,465.438636646268,2.97353819418192,1.57218060680641,0.000231436439086843,0.005658194553202,"up","yes","RABGGTA","protein_coding","chrNC_037337.1:20892675-20899746:+","gi|62751934|ref|NP_001015614.1|",2611,0,"geranylgeranyl transferase type-2 subunit alpha [Bos taurus]","gi|62751933|ref|NM_001015614.1|",1656,0,"Bos taurus Rab geranylgeranyltransferase alpha subunit (RABGGTA), mRNA","Q5EA80",1010,0,"Geranylgeranyl transferase type-2 subunit alpha","SPCC1620.05",143,{"v":3e-36,"d":"3.00E-36"},"COG5536","pfam07711","RabGGT_insert","Rab geranylgeranyl transferase alpha-subunit, insert domain. Rab geranylgeranyl transferase (RabGGT) catalyses the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular trafficking. This domain is inserted between pfam01239 repeats. This domain adopts an Ig-like fold and is thought to be involved in protein-protein interactions and might be involved in the recognition and binding of REP.","GO:0018344|protein geranylgeranylation;","GO:0005654|nucleoplasm;GO:0005968|Rab-protein geranylgeranyltransferase complex;","GO:0004663|Rab geranylgeranyltransferase activity;GO:0017137|Rab GTPase binding;GO:0008270|zinc ion binding;","K14050","RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]"]
["gene13132",881,982,824,804.496058726651,322,323,377,374.977088769995,2.14545390323864,1.10128290398378,{"v":3.79310055235866e-05,"d":"3.79E-05"},0.00128375980853315,"up","yes","RBM23","protein_coding","chrNC_037337.1:21924877-21973043:+","gi|926701905|ref|XP_013822340.1|",1762,0,"PREDICTED: probable RNA-binding protein 23 isoform X1 [Capra hircus]","gi|742233891|ref|XM_010831254.1|",1582,0,"PREDICTED: Bison bison bison RNA binding motif protein 23 (RBM23), transcript variant X2, mRNA","Q86U06",568,0,"Probable RNA-binding protein 23",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0006397|mRNA processing;","GO:0016020|membrane;GO:0005634|nucleus;","GO:0003723|RNA binding;",".","."]
["gene133",3522,3096,5596,3651.18163663168,1525,1027,1413,1456.94726226854,2.50604927933122,1.32541478431171,{"v":2.25744893399742e-06,"d":"2.26E-06"},0.000121509831580616,"up","yes","ADAMTS1","protein_coding","chrNC_037328.1:9583735-9592432:+","gi|155371891|ref|NP_001094550.1|",4855,0,"A disintegrin and metalloproteinase with thrombospondin motifs 1 [Bos taurus]","gi|155371890|ref|NM_001101080.1|",4255,0,"Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 1 (ADAMTS1), mRNA","P97857",1543,0,"A disintegrin and metalloproteinase with thrombospondin motifs 1",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0060347|heart trabecula formation;GO:0001822|kidney development;GO:0016525|negative regulation of angiogenesis;GO:0001542|ovulation from ovarian follicle;GO:0010976|positive regulation of neuron projection development;","GO:0005604|basement membrane;GO:0031410|cytoplasmic vesicle;GO:0031012|extracellular matrix;","GO:0008201|heparin binding;GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K08617","ADAMTS1; a disintegrin and metalloproteinase with thrombospondin motifs 1 [EC:3.4.24.-]"]
["gene1330",2033,396,602,844.510464885905,314,321,344,359.34086359158,2.35016540129919,1.23276229518896,{"v":9.22414229606697e-06,"d":"9.22E-06"},0.000403543400533427,"up","yes","ERG","protein_coding","chrNC_037328.1:150668908-150925161:-","gi|803319152|ref|XP_012017791.1|",2407,0,"PREDICTED: transcriptional regulator ERG isoform X3 [Ovis aries musimon]","gi|982912473|ref|XM_015473972.1|",2802,0,"PREDICTED: Bos taurus v-ets avian erythroblastosis virus E26 oncogene homolog (ERG), transcript variant X4, mRNA","P11308",914,0,"Transcriptional regulator ERG",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0030154|cell differentiation;GO:0016477|cell migration;GO:0008283|cell proliferation;GO:0003197|endocardial cushion development;GO:0003199|endocardial cushion to mesenchymal transition involved in heart valve formation;GO:0007275|multicellular organismal development;GO:2000504|positive regulation of blood vessel remodeling;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006468|protein phosphorylation;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09435","ERG; transcriptional regulator ERG"]
["gene13324",286,105,78,132.904089473281,38,61,48,53.9161277811373,2.46501547760961,1.30159670518352,0.00134455940637507,0.0228751487318349,"up","yes","LOC790312","protein_coding","chrNC_037337.1:26644437-26650567:-","gi|528965590|ref|XP_002690791.3|",1629,0,"PREDICTED: LOW QUALITY PROTEIN: purine nucleoside phosphorylase [Bos taurus]","gi|982988909|ref|XM_015465013.1|",1041,0,"PREDICTED: Bos taurus purine nucleoside phosphorylase (LOC790312), mRNA","P55859",551,0,"Purine nucleoside phosphorylase","YLR209c",258,{"v":3e-82,"d":"3.00E-82"},"COG0005","pfam01048","PNP_UDP_1","Phosphorylase superfamily. Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)","GO:0009116|nucleoside metabolic process;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0004731|purine-nucleoside phosphorylase activity;",".","."]
["gene13329",2254,3588,2160,2426.67853741557,329,977,610,701.710018529991,3.45823555790069,1.79003614157732,0.00240968513479591,0.0352206591090481,"up","yes","KLHL33","protein_coding","chrNC_037337.1:26692545-26702598:+","gi|982936487|ref|XP_010807374.2|",3819,0,"PREDICTED: kelch-like protein 33 isoform X1 [Bos taurus]","gi|982936488|ref|XM_005211459.3|",4775,0,"PREDICTED: Bos taurus kelch like family member 33 (KLHL33), transcript variant X2, mRNA","A6NCF5",859,0,"Kelch-like protein 33",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0016567|protein ubiquitination;","GO:0031463|Cul3-RING ubiquitin ligase complex;",".","K13957","KLHL33; kelch-like protein 33"]
["gene1335",5644,6757,9540,6615.28629172381,2727,2502,2522,2847.84210422484,2.32291189245003,1.21593443407093,{"v":2.40081225266775e-06,"d":"2.40E-06"},0.000126847359964562,"up","yes","ETS2","protein_coding","chrNC_037328.1:151162151-151181633:+","gi|122692289|ref|NP_001073683.1|",2355,0,"protein C-ets-2 [Bos taurus]","gi|122692288|ref|NM_001080214.1|",3440,0,"Bos taurus v-ets avian erythroblastosis virus E26 oncogene homolog 2 (ETS2), mRNA","A1A4L6",911,0,"Protein C-ets-2",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0030154|cell differentiation;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;",".","."]
["gene1339",1276,722,697,783.231193215012,96,151,100,127.394148420479,6.14809395035843,2.62013921133326,{"v":1.97765916701042e-14,"d":"1.98E-14"},{"v":6.26939929933047e-12,"d":"6.27E-12"},"up","yes","LOC530102","protein_coding","chrNC_037328.1:151564071-151743963:-","gi|982912677|ref|XP_015329636.1|",11308,0,"PREDICTED: collagen alpha-6(VI) chain [Bos taurus]","gi|982977049|ref|XM_015462215.1|",6625,0,"PREDICTED: Bos taurus collagen alpha-6(VI) chain (LOC530102), mRNA","A6NMZ7",3612,0,"Collagen alpha-6(VI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0007155|cell adhesion;","GO:0005581|collagen trimer;GO:0031012|extracellular matrix;GO:0005576|extracellular region;",".","K06238","COL6A; collagen, type VI, alpha"]
["gene1345",2310,2245,2348,2058.88746262227,610,666,843,776.712400925832,2.65077197192693,1.40641257019779,{"v":1.3176470567282e-08,"d":"1.32E-08"},{"v":1.36209377447509e-06,"d":"1.36E-06"},"up","yes","SH3BP5","protein_coding","chrNC_037328.1:152285108-152366452:-","gi|329664898|ref|NP_001193217.1|",1881,0,"SH3 domain-binding protein 5 [Bos taurus]","gi|999809038|ref|NM_001206288.2|",2580,0,"Bos taurus SH3-domain binding protein 5 (BTK-associated) (SH3BP5), mRNA","O60239",621,0,"SH3 domain-binding protein 5",".",".",".",".","pfam05276","SH3BP5","SH3 domain-binding protein 5 (SH3BP5). This family consists of several eukaryotic SH3 domain-binding protein 5 or c-Jun N-terminal kinase (JNK)-interacting proteins (SH3BP5 or Sab). Sab binds to and serves as a substrate for JNK in vitro, and has been found to interact with the Src homology 3 (SH3) domain of Bruton's tyrosine kinase (Btk). Inspection of the sequence of Sab reveals the presence of two putative mitogen-activated protein kinase interaction motifs (KIMs) similar to that found in the JNK docking domain of the c-Jun transcription factor, and four potential serine-proline JNK phosphorylation sites in the C-terminal half of the molecule.","GO:0035556|intracellular signal transduction;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0016604|nuclear body;GO:0005654|nucleoplasm;","GO:0004860|protein kinase inhibitor activity;GO:0017124|SH3 domain binding;",".","."]
["gene13573",4847,3656,5809,4245.44623375388,1168,1822,1651,1701.17871887101,2.49559096093758,1.31938148909365,{"v":3.4123597671402e-06,"d":"3.41E-06"},0.000170206357545939,"up","yes","RPS29","protein_coding","chrNC_037337.1:42627498-42629350:-","gi|759100021|ref|XP_011375277.1|",342,{"v":2e-38,"d":"2.00E-38"},"PREDICTED: LOW QUALITY PROTEIN: 40S ribosomal protein S29 [Pteropus vampyrus]","gi|942050652|ref|XM_005894294.2|",295,{"v":8e-152,"d":"8.00E-152"},"PREDICTED: Bos mutus ribosomal protein S29 (RPS29), transcript variant X2, mRNA","P62275",118,{"v":2e-34,"d":"2.00E-34"},"40S ribosomal protein S29","YLR388w",82.4,{"v":8e-21,"d":"8.00E-21"},"COG0199","pfam00253","Ribosomal_S14","Ribosomal protein S14p/S29e. This family includes both ribosomal S14 from prokaryotes and S29 from eukaryotes.","GO:0002181|cytoplasmic translation;GO:0043065|positive regulation of apoptotic process;","GO:0022627|cytosolic small ribosomal subunit;GO:0042788|polysomal ribosome;GO:0005791|rough endoplasmic reticulum;","GO:0003735|structural constituent of ribosome;GO:0008270|zinc ion binding;","K02980","RP-S29e, RPS29; small subunit ribosomal protein S29e"]
["gene13598",721,937,577,672.19000176736,228,288,293,296.676600747913,2.26573312513622,1.17997793983591,{"v":1.81201989664118e-05,"d":"1.81E-05"},0.000702972020820463,"up","yes","L2HGDH","protein_coding","chrNC_037337.1:43166823-43219854:-","gi|155371911|ref|NP_001094560.1|",2327,0,"L-2-hydroxyglutarate dehydrogenase, mitochondrial precursor [Bos taurus]","gi|155371910|ref|NM_001101090.1|",3265,0,"Bos taurus L-2-hydroxyglutarate dehydrogenase (L2HGDH), mRNA","A7MBI3",902,0,"L-2-hydroxyglutarate dehydrogenase, mitochondrial","alr2826",334,{"v":6e-103,"d":"6.00E-103"},"COG0579","pfam01266","DAO","FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.","GO:0044267|cellular protein metabolic process;","GO:0016021|integral component of membrane;GO:0005739|mitochondrion;","GO:0047545|2-hydroxyglutarate dehydrogenase activity;","K00109","E1.1.99.2; 2-hydroxyglutarate dehydrogenase [EC:1.1.99.2]"]
["gene13620",412,153,217,224.162972988086,98,93,91,103.607649603382,2.16357550669471,1.11341747030136,0.00101919611157073,0.018299990093911,"up","yes","PTGDR","protein_coding","chrNC_037337.1:45157991-45165484:+","gi|147900255|ref|NP_001091503.1|",1325,{"v":1e-170,"d":"1.00E-170"},"prostaglandin D2 receptor [Bos taurus]","gi|147900254|ref|NM_001098034.1|",3073,0,"Bos taurus prostaglandin D2 receptor (DP) (PTGDR), mRNA","A5D7K8",514,{"v":5e-172,"d":"5.00E-172"},"Prostaglandin D2 receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0046085|adenosine metabolic process;GO:0071799|cellular response to prostaglandin D stimulus;GO:0071380|cellular response to prostaglandin E stimulus;GO:0006954|inflammatory response;GO:0030238|male sex determination;GO:0030431|sleep;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004956|prostaglandin D receptor activity;GO:0004957|prostaglandin E receptor activity;GO:0001785|prostaglandin J receptor activity;","K04332","PTGDR; prostaglandin D2 receptor"]
["gene13642",104,150,228,146.286200974602,15,30,33,28.5282537414136,5.12776569854476,2.35833034283222,{"v":1.96609013488931e-07,"d":"1.97E-07"},{"v":1.48791823974872e-05,"d":"1.49E-05"},"up","yes","FBXL22","protein_coding","chrNC_037337.1:46403392-46407884:-","gi|803233395|ref|XP_011976843.1|",1052,{"v":2e-138,"d":"2.00E-138"},"PREDICTED: F-box and leucine-rich protein 22 isoform X2 [Ovis aries musimon]","gi|402744137|ref|NM_001046156.2|",1364,0,"Bos taurus F-box and leucine-rich repeat protein 22 (FBXL22), mRNA","Q2HJF2",397,{"v":7e-136,"d":"7.00E-136"},"F-box and leucine-rich protein 22",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.","GO:0016567|protein ubiquitination;","GO:0030018|Z disc;",".","K10288","FBXL22; F-box and leucine-rich repeat protein 22"]
["gene13654",45558,190111,205933,137422.688509246,17324,43820,29072,33050.757480593,4.15792856154473,2.05586497108937,0.000547034739978666,0.0112979242770059,"up","yes","TPM1","protein_coding","chrNC_037337.1:46993263-47022966:-","gi|830074122|ref|XP_012584089.1|",914,{"v":8e-113,"d":"8.00E-113"},"PREDICTED: tropomyosin alpha-1 chain isoform X6 [Condylura cristata]","gi|850484816|gb|CP011892.1|",1002,0,"Ovis canadensis canadensis isolate 43U chromosome 7 sequence","Q63610",187,{"v":4e-52,"d":"4.00E-52"},"Tropomyosin alpha-3 chain",".",".",".",".","pfam00261","Tropomyosin","Tropomyosin.","GO:0007015|actin filament organization;GO:0007420|brain development;GO:0006936|muscle contraction;","GO:0005884|actin filament;GO:0005903|brush border;GO:0005862|muscle thin filament tropomyosin;","GO:0051015|actin filament binding;GO:0008307|structural constituent of muscle;","K09290","TPM3; tropomyosin 3"]
["gene13758",189,71,89,99.859572376833,28,34,39,37.0210265204943,2.69737448586284,1.43155582983891,0.00119581409616923,0.0208162123110459,"up","yes","LYSMD2","protein_coding","chrNC_037337.1:58609344-58642587:+","gi|115497854|ref|NP_001068953.1|",895,{"v":1e-111,"d":"1.00E-111"},"lysM and putative peptidoglycan-binding domain-containing protein 2 [Bos taurus]","gi|115497853|ref|NM_001075485.1|",1452,0,"Bos taurus LysM domain containing 2 (LYSMD2), mRNA",".",".",".",".","YPO0370_2",54.3,{"v":1e-07,"d":"1.00E-07"},"COG1388","pfam01476","LysM","LysM domain. The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.",".",".",".",".","."]
["gene13766",190,161,755,334.157794725258,85,22,58,60.7804417137709,5.49778490092066,2.45885046297207,0.0018156902437888,0.0286682115913327,"up","yes","GLDN","protein_coding","chrNC_037337.1:58946643-59006602:-","gi|297479696|ref|XP_002690971.1|",2271,0,"PREDICTED: gliomedin [Bos taurus]","gi|982989632|ref|XM_001250146.4|",3047,0,"PREDICTED: Bos taurus gliomedin (GLDN), mRNA","Q6ZMI3",791,0,"Gliomedin",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0045162|clustering of voltage-gated sodium channels;GO:0032528|microvillus organization;","GO:0030424|axon;GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0086080|protein binding involved in heterotypic cell-cell adhesion;","K16364","GLDN; GLDN; gliomedin"]
["gene13776",7020,4214,2886,4096.93045735976,1439,1424,1300,1529.70733500623,2.67824463124711,1.42128774265188,{"v":8.98581394231104e-09,"d":"8.99E-09"},{"v":9.53064154602514e-07,"d":"9.53E-07"},"up","yes","TRPM7","protein_coding","chrNC_037337.1:59648210-59757063:+","gi|296483137|tpg|DAA25252.1|",9734,0,"TPA: transient receptor potential cation channel, subfamily M, member 7-like [Bos taurus]","gi|329663921|ref|NM_001206166.1|",6310,0,"Bos taurus transient receptor potential cation channel, subfamily M, member 7 (TRPM7), mRNA","Q96QT4",3643,0,"Transient receptor potential cation channel subfamily M member 7",".",".",".",".","pfam02816","Alpha_kinase","Alpha-kinase family. This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.","GO:0031032|actomyosin structure organization;GO:0070588|calcium ion transmembrane transport;GO:0016340|calcium-dependent cell-matrix adhesion;GO:0010961|cellular magnesium ion homeostasis;GO:0070266|necroptotic process;GO:0046777|protein autophosphorylation;GO:0051262|protein tetramerization;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0001726|ruffle;","GO:0003779|actin binding;GO:0005524|ATP binding;GO:0005262|calcium channel activity;GO:0046872|metal ion binding;GO:0017022|myosin binding;GO:0004674|protein serine/threonine kinase activity;","K04982","TRPM7, CHAK1; transient receptor potential cation channel subfamily M member 7 [EC:2.7.11.1]"]
["gene14025",642,254,283,337.475830878415,132,148,144,155.631644052109,2.16842681919764,1.11664875546195,0.00029391818479293,0.00689053387865826,"up","yes","EXD2","protein_coding","chrNC_037337.1:80972083-81028519:+","gi|297479852|ref|XP_002691029.1|",3094,0,"PREDICTED: exonuclease 3'-5' domain-containing protein 2 [Bos taurus]","gi|742153115|ref|XM_010846696.1|",3683,0,"PREDICTED: Bison bison bison exonuclease 3'-5' domain containing 2 (EXD2), transcript variant X2, mRNA","Q9NVH0",1077,0,"Exonuclease 3'-5' domain-containing protein 2",".",".",".",".","pfam01612","DNA_pol_A_exo1","3'-5' exonuclease. This domain is responsible for the 3'-5' exonuclease proofreading activity of Escherichia coli DNA polymerase I (polI) and other enzymes, it catalyses the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in Escherichia coli polI it is also found in the Werner syndrome helicase (WRN), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D). Werner syndrome is a human genetic disorder causing premature aging; the WRN protein has helicase activity in the 3'-5' direction. The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homologue of the WRN protein. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.","GO:0000729|DNA double-strand break processing;GO:0006302|double-strand break repair;GO:0000724|double-strand break repair via homologous recombination;GO:0090305|nucleic acid phosphodiester bond hydrolysis;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0008408|3'-5' exonuclease activity;GO:0008852|exodeoxyribonuclease I activity;GO:0003676|nucleic acid binding;GO:0008310|single-stranded DNA 3'-5' exodeoxyribonuclease activity;",".","."]
["gene14059",548,169,149,243.966944979765,43,102,85,84.1874554333989,2.89790140020051,1.53500850867617,0.00305109800276592,0.0419118329884037,"up","yes","RGS6","protein_coding","chrNC_037337.1:83454673-84066840:+","gi|528967073|ref|XP_005212157.1|",2872,0,"PREDICTED: regulator of G-protein signaling 6 isoform X1 [Bos taurus]","gi|982990032|ref|XM_015465212.1|",3000,0,"PREDICTED: Bos taurus regulator of G-protein signaling 6 (RGS6), transcript variant X4, mRNA","P49758",941,0,"Regulator of G-protein signaling 6",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0009968|negative regulation of signal transduction;GO:0043547|positive regulation of GTPase activity;GO:0008277|regulation of G-protein coupled receptor protein signaling pathway;","GO:0005829|cytosol;GO:0019898|extrinsic component of membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["gene14061",2145,1885,2055,1807.91962538275,465,890,634,729.277909615932,2.47905442019336,1.30978994180839,0.000855180816292462,0.0160339556692924,"up","yes","DPF3","protein_coding","chrNC_037337.1:84112006-84405625:-","gi|795432369|ref|XP_011760913.1|",1761,0,"PREDICTED: zinc finger protein DPF3 isoform X3 [Macaca nemestrina]","gi|742186119|ref|XM_010855811.1|",11488,0,"PREDICTED: Bison bison bison D4, zinc and double PHD fingers, family 3 (DPF3), transcript variant X4, mRNA","Q92784",676,0,"Zinc finger protein DPF3",".",".",".",".","pfam14051","Requiem_N","N-terminal domain of DPF2/REQ. This putative domain has been detected on the human DPF2 protein and was subsequently targeted for structure determination by the Joint Center for Structural Genomics (JCSG). Possibly, the C-terminus extends by 30 amino acids and forms a separate domain. DPF2 interacts with estrogen related receptor alpha (Err-alpha), an orphan receptor which acts as a regulator in energy metabolizm. It was also identified as an adaptor molecule that links nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa-B) dimer RelB/p52 and switch/sucrose-nonfermentable (SWI/SNF) chromatin remodeling factor.","GO:0006325|chromatin organization;GO:0007399|nervous system development;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0071565|nBAF complex;GO:0005654|nucleoplasm;","GO:0003676|nucleic acid binding;GO:0008270|zinc ion binding;",".","."]
["gene14127",98,0,0,25.5410772099487,0,0,0,0,"Inf","Inf",{"v":6.82649126819937e-08,"d":"6.83E-08"},{"v":5.91995812683879e-06,"d":"5.92E-06"},"up","yes","LOC509034","protein_coding","chrNC_037337.1:86875770-86908135:+","gi|742141685|ref|XP_010842710.1|",2038,0,"PREDICTED: feline leukemia virus subgroup C receptor-related protein 2-like [Bison bison bison]","gi|982990122|ref|XM_015465238.1|",1675,0,"PREDICTED: Bos taurus feline leukemia virus subgroup C receptor-related protein 2 (LOC509034), mRNA","Q9UPI3",681,0,"Feline leukemia virus subgroup C receptor-related protein 2",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.",".","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0020037|heme binding;GO:0015232|heme transporter activity;","K08220","FLVCR, SLC49A1_2; MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein"]
["gene14176",1079,454,1406,861.809315759056,70,28,48,53.7661168904019,16.0288554502789,4.00259950758139,{"v":8.13659553631641e-12,"d":"8.14E-12"},{"v":1.65818005176174e-09,"d":"1.66E-09"},"up","yes","DIO2","protein_coding","chrNC_037337.1:91490126-91504569:-","gi|58330899|ref|NP_001010992.1|",1418,{"v":2e-177,"d":"2.00E-177"},"type II iodothyronine deiodinase [Bos taurus]","gi|965948716|ref|XM_015097211.1|",5340,0,"PREDICTED: Ovis aries deiodinase, iodothyronine, type II (DIO2), transcript variant X1, mRNA","Q5I3B2",550,{"v":8e-179,"d":"8.00E-179"},"Type II iodothyronine deiodinase",".",".",".",".","pfam00837","T4_deiodinase","Iodothyronine deiodinase. Iodothyronine deiodinase converts thyroxine (T4) to 3,5,3'-triiodothyronine (T3).","GO:0042446|hormone biosynthetic process;GO:0042403|thyroid hormone metabolic process;","GO:0016021|integral component of membrane;","GO:0004800|thyroxine 5'-deiodinase activity;","K17904","DIO2; type II thyroxine 5'-deiodinase [EC:1.97.1.10]"]
["gene14184",47,117,121,87.7539782650535,27,34,14,27.6229362189784,3.17685193092405,1.66759784941566,0.00182279322159164,0.0287485425125655,"up","yes","TSHR","protein_coding","chrNC_037337.1:92281884-92430339:+","gi|296482885|tpg|DAA25000.1|",3894,0,"TPA: thyrotropin receptor precursor [Bos taurus]","gi|402744600|ref|NM_174206.3|",2367,0,"Bos taurus thyroid stimulating hormone receptor (TSHR), mRNA","Q27987",1498,0,"Thyrotropin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007190|activation of adenylate cyclase activity;GO:0007189|adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0007166|cell surface receptor signaling pathway;GO:1904588|cellular response to glycoprotein;GO:0009755|hormone-mediated signaling pathway;GO:0007399|nervous system development;GO:0045762|positive regulation of adenylate cyclase activity;GO:0030819|positive regulation of cAMP biosynthetic process;GO:0038194|thyroid-stimulating hormone signaling pathway;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0008528|G-protein coupled peptide receptor activity;GO:0044877|macromolecular complex binding;GO:0038023|signaling receptor activity;GO:0004996|thyroid-stimulating hormone receptor activity;","K04249","TSHR; thyroid stimulating hormone receptor"]
["gene14278",663,214,265,324.312022278766,125,94,99,116.954158714989,2.77298409771897,1.4714393429523,{"v":4.75610603530388e-06,"d":"4.76E-06"},0.000226538332709942,"up","yes","MALL","protein_coding","chrNC_037338.1:1774913-1807070:+","gi|114051896|ref|NP_001039580.1|",707,{"v":5e-86,"d":"5.00E-86"},"MAL-like protein [Bos taurus]","gi|402693396|ref|NM_001046115.2|",1969,0,"Bos taurus mal, T-cell differentiation protein-like (MALL), mRNA","Q91X49",228,{"v":6e-69,"d":"6.00E-69"},"MAL-like protein",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0001766|membrane raft polarization;GO:0042552|myelination;GO:0008104|protein localization;","GO:0030136|clathrin-coated vesicle;GO:0031410|cytoplasmic vesicle;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0045121|membrane raft;GO:0005886|plasma membrane;","GO:0019911|structural constituent of myelin sheath;",".","."]
["gene14289",226,80,68,106.002536946862,31,29,44,38.1122573883679,2.78132402042432,1.47577182646413,0.000719529450194135,0.0140812569561645,"up","yes","ADRA2B","protein_coding","chrNC_037338.1:2253295-2254638:-","gi|331028819|ref|NP_001193557.1|",1990,0,"alpha-2B adrenergic receptor [Bos taurus]","gi|331028818|ref|NM_001206628.1|",1344,0,"Bos taurus adrenoceptor alpha 2B (ADRA2B), mRNA","O77700",670,0,"Alpha-2B adrenergic receptor (Fragment)",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0030168|platelet activation;GO:0006940|regulation of smooth muscle contraction;GO:0019229|regulation of vasoconstriction;","GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;","GO:0004935|adrenergic receptor activity;GO:0004938|alpha2-adrenergic receptor activity;",".","."]
["gene14397",418,723,1442,788.749790726785,111,100,149,131.971975289,5.97664609474499,2.57933611655089,{"v":1.26729895658202e-19,"d":"1.27E-19"},{"v":7.86028402831342e-17,"d":"7.86E-17"},"up","yes","FHL2","protein_coding","chrNC_037338.1:9268523-9316088:-","gi|440896699|gb|ELR48557.1|",1486,0,"Four and a half LIM domains protein 2, partial [Bos mutus]","gi|594089054|ref|XM_006067897.1|",1455,0,"PREDICTED: Bubalus bubalis four and a half LIM domains 2 (FHL2), transcript variant X3, mRNA","Q2KI95",572,0,"Four and a half LIM domains protein 2",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0055014|atrial cardiac muscle cell development;GO:0060347|heart trabecula formation;GO:0043066|negative regulation of apoptotic process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0001649|osteoblast differentiation;GO:0009725|response to hormone;GO:0006351|transcription, DNA-templated;GO:0055015|ventricular cardiac muscle cell development;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0008134|transcription factor binding;","K14380","FHL2; four and a half LIM domains protein 2"]
["gene14480",0,0,249,76.4732867684173,1,10,5,5.84850822234553,13.0756910755864,3.70881529260041,0.000823998375523917,0.0156209286724737,"up","yes","VAX2","protein_coding","chrNC_037338.1:13482524-13508824:-","gi|300796717|ref|NP_001179242.1|",956,{"v":2e-126,"d":"2.00E-126"},"ventral anterior homeobox 2 [Bos taurus]","gi|300796716|ref|NM_001192313.1|",858,0,"Bos taurus ventral anterior homeobox 2 (VAX2), mRNA","Q9UIW0",337,{"v":8e-114,"d":"8.00E-114"},"Ventral anterior homeobox 2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0007409|axonogenesis;GO:0009950|dorsal/ventral axis specification;GO:0007398|ectoderm development;GO:0048048|embryonic eye morphogenesis;GO:0030900|forebrain development;GO:0060041|retina development in camera-type eye;GO:0006351|transcription, DNA-templated;GO:0007601|visual perception;GO:0016055|Wnt signaling pathway;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0031490|chromatin DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0001162|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09318","VAX; homeobox protein ventral anterior"]
["gene14536",194,178,176,162.948062360024,62,68,45,64.3725562631409,2.53132812830871,1.33989453170795,0.00040800769941782,0.00898908700547477,"up","yes","QPCT","protein_coding","chrNC_037338.1:19792187-19822477:+","gi|555963458|ref|XP_005893809.1|",1777,0,"PREDICTED: glutaminyl-peptide cyclotransferase [Bos mutus]","gi|31343553|ref|NM_177506.2|",2082,0,"Bos taurus glutaminyl-peptide cyclotransferase (QPCT), mRNA","Q28120",648,0,"Glutaminyl-peptide cyclotransferase",".",".",".",".","pfam04389","Peptidase_M28","Peptidase family M28.","GO:0017186|peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase;","GO:0005576|extracellular region;","GO:0016603|glutaminyl-peptide cyclotransferase activity;GO:0008270|zinc ion binding;","K00683","QPCT; glutaminyl-peptide cyclotransferase [EC:2.3.2.5]"]
["gene14545",4843,5949,5032,4757.22686991375,1665,2707,1782,2259.01290663593,2.10588742363499,1.07442831494645,0.00272650952627296,0.0385480888474201,"up","yes","ATL2","protein_coding","chrNC_037338.1:20672185-20740177:-","gi|594049233|ref|XP_006048999.1|",3049,0,"PREDICTED: atlastin-2 isoform X1 [Bubalus bubalis]","gi|965925654|ref|XM_015094430.1|",3799,0,"PREDICTED: Ovis aries atlastin GTPase 2 (ATL2), transcript variant X1, mRNA","Q6PA06",1088,0,"Atlastin-2",".",".",".",".","pfam02263","GBP","Guanylate-binding protein, N-terminal domain. Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.","GO:0007029|endoplasmic reticulum organization;GO:1990809|endoplasmic reticulum tubular network membrane organization;GO:0007030|Golgi organization;GO:0051260|protein homooligomerization;","GO:0005783|endoplasmic reticulum;GO:0098826|endoplasmic reticulum tubular network membrane;GO:0016021|integral component of membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0042802|identical protein binding;","K17339","ATL; atlastin [EC:3.6.5.-]"]
["gene14688",640,210,571,410.986036998786,41,80,76,72.1174367391822,5.69884421274075,2.51066935478192,{"v":6.37938057889949e-10,"d":"6.38E-10"},{"v":8.96601513776262e-08,"d":"8.97E-08"},"up","yes","EML6","protein_coding","chrNC_037338.1:37435370-37722354:+","gi|300794456|ref|NP_001179386.1|",10135,0,"echinoderm microtubule-associated protein-like 6 [Bos taurus]","gi|982938707|ref|XM_010809938.2|",8971,0,"PREDICTED: Bos taurus echinoderm microtubule associated protein like 6 (EML6), transcript variant X1, mRNA","Q6ZMW3",3856,0,"Echinoderm microtubule-associated protein-like 6",".",".",".",".","pfam03451","HELP","HELP motif. The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.",".","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;","GO:0008017|microtubule binding;","K18598","EML6; echinoderm microtubule-associated protein-like 6"]
["gene14708",723,170,198,304.952689152106,112,136,139,141.947566978272,2.14834741900708,1.10322731694957,0.000895382858586266,0.0166099924176364,"up","yes","CCDC85A","protein_coding","chrNC_037338.1:38849960-39079710:+","gi|594080200|ref|XP_006063741.1|",2443,0,"PREDICTED: coiled-coil domain-containing protein 85A-like isoform X1 [Bubalus bubalis]","gi|850480667|gb|CP011888.1|",4830,0,"Ovis canadensis canadensis isolate 43U chromosome 3 sequence",".",".",".",".",".",".",".",".","pfam10226","DUF2216","Uncharacterized conserved proteins (DUF2216). This is the conserved N-terminal half of a proteins which are found from worms to humans. some annotation suggests it might be PKR, the Hepatitis delta antigen-interacting protein A, but this could not be confirmed.",".",".",".",".","."]
["gene14761",1444,2222,2109,1752.24816246802,593,721,699,738.562563749841,2.37251148172401,1.24641506915838,{"v":6.43086742539125e-07,"d":"6.43E-07"},{"v":4.16997905713268e-05,"d":"4.17E-05"},"up","yes","UXS1","protein_coding","chrNC_037338.1:45721331-45778563:+","gi|803212204|ref|XP_011966515.1|",2037,0,"PREDICTED: UDP-glucuronic acid decarboxylase 1 isoform X6 [Ovis aries musimon]","gi|329663220|ref|NM_001206064.1|",2017,0,"Bos taurus UDP-glucuronate decarboxylase 1 (UXS1), mRNA","Q5R885",781,0,"UDP-glucuronic acid decarboxylase 1","alr0657",438,{"v":3e-148,"d":"3.00E-148"},"COG0451","pfam01370","Epimerase","NAD dependent epimerase/dehydratase family. This family of proteins utilize NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions.","GO:0033320|UDP-D-xylose biosynthetic process;","GO:0032580|Golgi cisterna membrane;GO:0016021|integral component of membrane;","GO:0048040|UDP-glucuronate decarboxylase activity;","K08678","UXS1, uxs; UDP-glucuronate decarboxylase [EC:4.1.1.35]"]
["gene14826",2016,2488,2475,2100.90407450785,599,869,696,794.036413836029,2.64585356275826,1.40373321651883,{"v":3.69830372349435e-08,"d":"3.70E-08"},{"v":3.4823862552811e-06,"d":"3.48E-06"},"up","yes","REEP1","protein_coding","chrNC_037338.1:48518943-48655847:+","gi|528968824|ref|XP_005212866.1|",1389,{"v":3e-177,"d":"3.00E-177"},"PREDICTED: receptor expression-enhancing protein 1 isoform X1 [Bos taurus]","gi|741943179|ref|XM_005212809.2|",4037,0,"PREDICTED: Bos taurus receptor accessory protein 1 (REEP1), transcript variant X1, mRNA","Q9H902",305,{"v":1e-93,"d":"1.00E-93"},"Receptor expression-enhancing protein 1","SPBC30D10.09c",64.7,{"v":2e-10,"d":"2.00E-10"},"COG5052","pfam03134","TB2_DP1_HVA22","TB2/DP1, HVA22 family. This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.","GO:0071786|endoplasmic reticulum tubular network organization;GO:0051205|protein insertion into membrane;GO:0032386|regulation of intracellular transport;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0071782|endoplasmic reticulum tubular network;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0031966|mitochondrial membrane;","GO:0008017|microtubule binding;GO:0031849|olfactory receptor binding;","K17338","REEP1_2_3_4; receptor expression-enhancing protein 1/2/3/4"]
["gene14864",351,148,239,213.383043084422,95,70,95,95.489522799883,2.23462257248481,1.16003118094508,0.000786658886029791,0.0150631977700107,"up","yes","TCF7L1","protein_coding","chrNC_037338.1:49674153-49876757:-","gi|741943340|ref|XP_002691454.3|",2069,0,"PREDICTED: transcription factor 7-like 1 isoform X1 [Bos taurus]","gi|982990799|ref|XM_015465393.1|",2748,0,"PREDICTED: Bos taurus transcription factor 7-like 1 (T-cell specific, HMG-box) (TCF7L1), transcript variant X2, mRNA","Q9HCS4",740,0,"Transcription factor 7-like 1",".",".",".",".","pfam08347","CTNNB1_binding","N-terminal CTNNB1 binding. This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.","GO:0060070|canonical Wnt signaling pathway;GO:0006325|chromatin organization;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006355|regulation of transcription, DNA-templated;GO:0030111|regulation of Wnt signaling pathway;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0008013|beta-catenin binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0044212|transcription regulatory region DNA binding;","K04490","TCF7L1; transcription factor 7-like 1"]
["gene1487",104,336,528,299.378179389459,28,96,55,65.5498220130917,4.56718523705017,2.19130530409204,0.00353739679351107,0.0466599481810746,"up","yes","MSTN","protein_coding","chrNC_037329.1:6278864-6285491:+","gi|426338082|ref|XP_004033021.1|",2035,0,"PREDICTED: growth/differentiation factor 8 [Gorilla gorilla gorilla]","gi|75677552|ref|NM_001001525.2|",2761,0,"Bos taurus myostatin (MSTN), mRNA","O18836",758,0,"Growth/differentiation factor 8",".",".",".",".","pfam00688","TGFb_propeptide","TGF-beta propeptide. This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.","GO:0048468|cell development;GO:0071549|cellular response to dexamethasone stimulus;GO:0046716|muscle cell cellular homeostasis;GO:0048147|negative regulation of fibroblast proliferation;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0033673|negative regulation of kinase activity;GO:0045662|negative regulation of myoblast differentiation;GO:0051898|negative regulation of protein kinase B signaling;GO:0048632|negative regulation of skeletal muscle tissue growth;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0042981|regulation of apoptotic process;GO:0043408|regulation of MAPK cascade;GO:0060395|SMAD protein signal transduction;GO:0007179|transforming growth factor beta receptor signaling pathway;","GO:0005623|cell;GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0005160|transforming growth factor beta receptor binding;","K05497","GDF8_11; growth differentiation factor 8/11"]
["gene14961",1943,6195,4284,3852.3110502347,1192,1781,1229,1542.77210377962,2.49700590307341,1.32019923188874,{"v":8.94686989397398e-05,"d":"8.95E-05"},0.00265622419297577,"up","yes","PPP3R1","protein_coding","chrNC_037338.1:66605841-66667440:-","gi|966647643|gb|KTF82553.1|",896,{"v":5e-118,"d":"5.00E-118"},"hypothetical protein cypCar_00025180, partial [Cyprinus carpio]","gi|31341611|ref|NM_174583.2|",841,0,"Bos taurus protein phosphatase 3 regulatory subunit B, alpha (PPP3R1), mRNA","P63100",344,{"v":1e-118,"d":"1.00E-118"},"Calcineurin subunit B type 1","YKL190w",192,{"v":2e-59,"d":"2.00E-59"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0001569|patterning of blood vessels;GO:0033173|calcineurin-NFAT signaling cascade;GO:0001837|epithelial to mesenchymal transition;GO:0007507|heart development;GO:0060487|lung epithelial cell differentiation;GO:0022011|myelination in peripheral nervous system;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006470|protein dephosphorylation;GO:0006606|protein import into nucleus;","GO:0005955|calcineurin complex;GO:0005829|cytosol;GO:0042383|sarcolemma;","GO:0005509|calcium ion binding;GO:0016018|cyclosporin A binding;GO:0019902|phosphatase binding;GO:0004721|phosphoprotein phosphatase activity;GO:0019904|protein domain specific binding;","K06268","PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit"]
["gene14965",31,318,207,175.867720486496,45,29,46,44.0669564278628,3.99092051601952,1.99672154612897,{"v":6.01634054148108e-07,"d":"6.02E-07"},{"v":3.98264993013914e-05,"d":"3.98E-05"},"up","yes","PLEK","protein_coding","chrNC_037338.1:66787639-66814889:+","gi|300795250|ref|NP_001179425.1|",1794,0,"pleckstrin [Bos taurus]","gi|942048921|ref|XM_005893576.2|",2500,0,"PREDICTED: Bos mutus pleckstrin (PLEK), mRNA","P08567",666,0,"Pleckstrin",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0031532|actin cytoskeleton reorganization;GO:0030030|cell projection organization;GO:0030866|cortical actin cytoskeleton organization;GO:0002244|hematopoietic progenitor cell differentiation;GO:0007229|integrin-mediated signaling pathway;GO:0050849|negative regulation of calcium-mediated signaling;GO:0045744|negative regulation of G-protein coupled receptor protein signaling pathway;GO:0010920|negative regulation of inositol phosphate biosynthetic process;GO:0046488|phosphatidylinositol metabolic process;GO:0030845|phospholipase C-inhibiting G-protein coupled receptor signaling pathway;GO:0070527|platelet aggregation;GO:0002576|platelet degranulation;GO:0032233|positive regulation of actin filament bundle assembly;GO:0030836|positive regulation of actin filament depolymerization;GO:0010925|positive regulation of inositol-polyphosphate 5-phosphatase activity;GO:0033625|positive regulation of integrin activation;GO:0010572|positive regulation of platelet activation;GO:0070528|protein kinase C signaling;GO:0070560|protein secretion by platelet;GO:0060305|regulation of cell diameter;GO:0031529|ruffle organization;GO:0070493|thrombin receptor signaling pathway;GO:0006904|vesicle docking involved in exocytosis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005576|extracellular region;GO:0016020|membrane;GO:0032587|ruffle membrane;","GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0042803|protein homodimerization activity;GO:0005080|protein kinase C binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["gene1498",6069,4369,6947,5147.09495348805,2504,1629,2172,2317.7711614272,2.22070885993708,1.15102026462871,{"v":9.46592447097311e-05,"d":"9.47E-05"},0.00277852151318245,"up","yes","COL5A2","protein_coding","chrNC_037329.1:7198093-7358813:+","gi|556751440|ref|XP_005971122.1|",1974,0,"PREDICTED: collagen alpha-2(V) chain-like [Pantholops hodgsonii]","gi|742214764|ref|XM_010862914.1|",6349,0,"PREDICTED: Bison bison bison collagen, type V, alpha 2 (COL5A2), transcript variant X1, mRNA","P05997",713,0,"Collagen alpha-2(V) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0071230|cellular response to amino acid stimulus;GO:0030199|collagen fibril organization;GO:0030198|extracellular matrix organization;GO:0048592|eye morphogenesis;GO:1903225|negative regulation of endodermal cell differentiation;GO:0001503|ossification;GO:0001501|skeletal system development;GO:0043588|skin development;","GO:0005588|collagen type V trimer;GO:0005788|endoplasmic reticulum lumen;GO:0031012|extracellular matrix;GO:0005576|extracellular region;","GO:0005201|extracellular matrix structural constituent;GO:0046872|metal ion binding;GO:0046332|SMAD binding;",".","."]
["gene1500",69285,47212,65892,53766.3467166036,6602,6606,6957,7403.22519711408,7.26255723486066,2.86047762817283,{"v":3.23835954210862e-16,"d":"3.24E-16"},{"v":1.33903820428842e-13,"d":"1.34E-13"},"up","yes","COL3A1","protein_coding","chrNC_037329.1:7375278-7414912:-","gi|116003881|ref|NP_001070299.1|",1325,{"v":4e-151,"d":"4.00E-151"},"collagen alpha-1(III) chain precursor [Bos taurus]","gi|116003880|ref|NM_001076831.1|",5416,0,"Bos taurus collagen type III alpha 1 (COL3A1), mRNA","P02461",488,{"v":4e-143,"d":"4.00E-143"},"Collagen alpha-1(III) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0007568|aging;GO:0060414|aorta smooth muscle tissue morphogenesis;GO:0007160|cell-matrix adhesion;GO:0071230|cellular response to amino acid stimulus;GO:0021987|cerebral cortex development;GO:0030199|collagen fibril organization;GO:0048565|digestive tract development;GO:0030198|extracellular matrix organization;GO:0007507|heart development;GO:0007229|integrin-mediated signaling pathway;GO:0050777|negative regulation of immune response;GO:2001223|negative regulation of neuron migration;GO:0018149|peptide cross-linking;GO:0030168|platelet activation;GO:0035025|positive regulation of Rho protein signal transduction;GO:0050776|regulation of immune response;GO:0034097|response to cytokine;GO:0009612|response to mechanical stimulus;GO:0009314|response to radiation;GO:0001501|skeletal system development;GO:0043588|skin development;GO:0097435|fibril organization;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0042060|wound healing;","GO:0005586|collagen type III trimer;GO:0005788|endoplasmic reticulum lumen;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005201|extracellular matrix structural constituent;GO:0005178|integrin binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;GO:0002020|protease binding;GO:0046332|SMAD binding;",".","."]
["gene15001",653,158,422,351.571696351307,124,95,109,120.557107078326,2.91622538788103,1.54410222632201,{"v":1.10593958902054e-06,"d":"1.11E-06"},{"v":6.68507678270022e-05,"d":"6.69E-05"},"up","yes","LBH","protein_coding","chrNC_037338.1:69617500-69644634:-","gi|149642787|ref|NP_001092622.1|",554,{"v":3e-63,"d":"3.00E-63"},"protein LBH [Bos taurus]","gi|982939181|ref|XM_005212885.3|",2938,0,"PREDICTED: Bos taurus limb bud and heart development (LBH), transcript variant X1, mRNA","A5PJU8",218,{"v":9e-65,"d":"9.00E-65"},"Protein LBH",".",".",".",".","pfam15317","Lbh","Cardiac transcription factor regulator, Developmental protein. The family of proteins are cardiac transcription regulators, named Lbh, short for Limb, bud and heart. They regulate embryological development in the heart. More specifically, in humans, they may act as transcriptional activators in MAPK signaling pathway to mediate cellular functions. This family of proteins is found in eukaryotes. Proteins in this family are typically between 92 and 116 amino acids in length.","GO:0060644|mammary gland epithelial cell differentiation;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:2000737|negative regulation of stem cell differentiation;GO:2000103|positive regulation of mammary stem cell proliferation;GO:1904677|positive regulation of somatic stem cell division;GO:1904674|positive regulation of somatic stem cell population maintenance;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".",".","."]
["gene15003",36,161,212,127.254769203282,6,23,20,17.9027803969314,7.10810088611118,2.82946415785215,{"v":6.28687626824099e-05,"d":"6.29E-05"},0.00197563276674446,"up","yes","ALK","protein_coding","chrNC_037338.1:69930341-70663168:+","gi|594074646|ref|XP_006061114.1|",7230,0,"PREDICTED: ALK tyrosine kinase receptor [Bubalus bubalis]","gi|594074645|ref|XM_006061052.1|",6877,0,"PREDICTED: Bubalus bubalis anaplastic lymphoma receptor tyrosine kinase (ALK), mRNA","Q9UM73",2540,0,"ALK tyrosine kinase receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0000187|activation of MAPK activity;GO:0030534|adult behavior;GO:0008283|cell proliferation;GO:0021766|hippocampus development;GO:0048666|neuron development;GO:0016310|phosphorylation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0046777|protein autophosphorylation;GO:0042981|regulation of apoptotic process;GO:0042127|regulation of cell proliferation;GO:0060159|regulation of dopamine receptor signaling pathway;GO:0090648|response to environmental enrichment;GO:0007165|signal transduction;GO:0036269|swimming behavior;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;","GO:0070062|extracellular exosome;GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0004704|NF-kappaB-inducing kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;","K05119","ALK; anaplastic lymphoma kinase [EC:2.7.10.1]"]
["gene15030",0,39,0,12.7809894890571,0,0,0,0,"Inf","Inf",0.000111845503205902,0.0031783506493701,"up","yes","C11H2orf16","protein_coding","chrNC_037338.1:72106607-72118087:-","gi|982939465|ref|XP_002691544.4|",18255,0,"PREDICTED: uncharacterized protein C2orf16 homolog [Bos taurus]","gi|982990945|ref|XM_001787492.4|",11466,0,"PREDICTED: Bos taurus chromosome 11 open reading frame, human C2orf16 (C11H2orf16), mRNA","Q68DN1",1650,0,"Uncharacterized protein C2orf16",".",".",".",".","pfam11725","AvrE","Pathogenicity factor. This family is secreted by gram-negative Gammaproteobacteria such as Pseudomonas syringae of tomato and the fire blight plant pathogen Erwinia amylovora, amongst others. It is an essential pathogenicity factor of approximately 198 kDa. Its injection into the host-plant is dependent upon the bacterial type III or Hrp secretion system. The family is long and carries a number of predicted functional regions, including an ERMS or endoplasmic reticulum membrane retention signal at both the C- and the N-termini, a leucine-zipper motif from residues 539-560, and a nuclear localisation signal at 1358-1361. this conserved AvrE-family of effectors is among the few that are required for full virulence of many phytopathogenic pseudomonads, erwinias and pantoeas.",".","GO:0070062|extracellular exosome;GO:0005634|nucleus;",".",".","."]
["gene15048",903,1466,674,922.776881631823,351,245,304,330.840312147094,2.78919118303077,1.47984682621179,{"v":4.36328630965695e-08,"d":"4.36E-08"},{"v":4.01577166776847e-06,"d":"4.02E-06"},"up","yes","SLC5A6","protein_coding","chrNC_037338.1:72419512-72430699:+","gi|296482286|tpg|DAA24401.1|",2975,0,"TPA: solute carrier family 5 (sodium-dependent vitamin transporter), member 6 [Bos taurus]","gi|742122654|ref|XM_010840623.1|",3109,0,"PREDICTED: Bison bison bison solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 (SLC5A6), transcript variant X4, mRNA","Q9XT77",1002,0,"Sodium-dependent multivitamin transporter","sll1087",169,{"v":2e-43,"d":"2.00E-43"},"COG0591","pfam00474","SSF","Sodium:solute symporter family. Membership of this family is supported by a significant blast score.","GO:0006814|sodium ion transport;","GO:0016021|integral component of membrane;","GO:0015293|symporter activity;","K14386","SLC5A6, SMVT; solute carrier family 5 (sodium-dependent multivitamin transporter), member 6"]
["gene15149",200,278,433,276.213829538983,88,25,57,62.6417358028407,4.40942170581513,2.14058945921601,0.00140682908102226,0.0236803778823871,"up","yes","OSR1","protein_coding","chrNC_037338.1:79406010-79413111:+","gi|255760026|ref|NP_001070384.2|",1312,{"v":3e-175,"d":"3.00E-175"},"protein odd-skipped-related 1 [Bos taurus]","gi|255760025|ref|NM_001076916.2|",1924,0,"Bos taurus odd-skipped related transciption factor 1 (OSR1), mRNA","Q08DS3",509,{"v":1e-176,"d":"1.00E-176"},"Protein odd-skipped-related 1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0072111|cell proliferation involved in kidney development;GO:0007507|heart development;GO:0072143|mesangial cell development;GO:0072207|metanephric epithelium development;GO:0072239|metanephric glomerulus vasculature development;GO:0072259|metanephric interstitial fibroblast development;GO:0072162|metanephric mesenchymal cell differentiation;GO:0072075|metanephric mesenchyme development;GO:0072234|metanephric nephron tubule development;GO:0072208|metanephric smooth muscle tissue development;GO:0072183|negative regulation of nephron tubule epithelial cell differentiation;GO:0050679|positive regulation of epithelial cell proliferation;GO:2000543|positive regulation of gastrulation;GO:0048793|pronephros development;GO:0006355|regulation of transcription, DNA-templated;GO:0072184|renal vesicle progenitor cell differentiation;GO:0072168|specification of anterior mesonephric tubule identity;GO:0072169|specification of posterior mesonephric tubule identity;GO:0048863|stem cell differentiation;GO:0006351|transcription, DNA-templated;GO:0072190|ureter urothelium development;GO:0001655|urogenital system development;","GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0003676|nucleic acid binding;","K09215","OSR, ODD; odd-skipped"]
["gene15152",2,50,0,16.907130434002,0,0,0,0,"Inf","Inf",{"v":9.1713619530719e-06,"d":"9.17E-06"},0.000402566350589376,"up","yes","NT5C1B","protein_coding","chrNC_037338.1:80143685-80157735:+","gi|556756659|ref|XP_005973679.1|",2769,0,"PREDICTED: cytosolic 5'-nucleotidase 1B isoform X2 [Pantholops hodgsonii]","gi|556756658|ref|XM_005973617.1|",1629,0,"PREDICTED: Pantholops hodgsonii 5'-nucleotidase, cytosolic IB (NT5C1B), transcript variant X2, mRNA","Q96P26",770,0,"Cytosolic 5'-nucleotidase 1B",".",".",".",".","pfam06189","5-nucleotidase","5'-nucleotidase. This family consists of both eukaryotic and prokaryotic 5'-nucleotidase sequences (EC:3.1.3.5).","GO:0006195|purine nucleotide catabolic process;","GO:0005829|cytosol;GO:0005634|nucleus;","GO:0008253|5'-nucleotidase activity;GO:0000287|magnesium ion binding;GO:0000166|nucleotide binding;","K01081","E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]"]
["gene15199",12901,10565,10919,10178.0987766085,5045,3699,4787,4971.12424970036,2.04744405196108,1.03382402961422,0.000129600517227677,0.00361096909865514,"up","yes","LPIN1","protein_coding","chrNC_037338.1:86081383-86211617:-","gi|440899686|gb|ELR50954.1|",4297,0,"Phosphatidate phosphatase LPIN1, partial [Bos mutus]","gi|942076945|ref|XM_005903204.2|",5290,0,"PREDICTED: Bos mutus lipin 1 (LPIN1), transcript variant X2, mRNA","Q91ZP3",1450,0,"Phosphatidate phosphatase LPIN1","YMR165c_1",214,{"v":7e-57,"d":"7.00E-57"},"COG5083","pfam08235","LNS2","LNS2 (Lipin/Ned1/Smp2). This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571) and phosphatidylinositol transfer proteins. SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration, and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain. Lipin proteins are involved in adipose tissue development and insulin resistance.","GO:0031532|actin cytoskeleton reorganization;GO:0032869|cellular response to insulin stimulus;GO:0045444|fat cell differentiation;GO:0009062|fatty acid catabolic process;GO:0006629|lipid metabolic process;GO:0000266|mitochondrial fission;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0031065|positive regulation of histone deacetylation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045598|regulation of fat cell differentiation;GO:0031529|ruffle organization;GO:0006351|transcription, DNA-templated;GO:0019432|triglyceride biosynthetic process;GO:0006642|triglyceride mobilization;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005741|mitochondrial outer membrane;GO:0031965|nuclear membrane;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0042826|histone deacetylase binding;GO:0042975|peroxisome proliferator activated receptor binding;GO:0008195|phosphatidate phosphatase activity;GO:0001085|RNA polymerase II transcription factor binding;GO:0003713|transcription coactivator activity;","K15728","LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]"]
["gene1521",0,71,6,25.1106850253166,0,0,0,0,"Inf","Inf",{"v":8.37136985904014e-08,"d":"8.37E-08"},{"v":7.0901949292977e-06,"d":"7.09E-06"},"up","yes","FSIP2","protein_coding","chrNC_037329.1:10562877-10705291:-","gi|982913018|ref|XP_015330091.1|",34294,0,"PREDICTED: LOW QUALITY PROTEIN: fibrous sheath-interacting protein 2 [Bos taurus]","gi|742201718|ref|XM_010859740.1|",20430,0,"PREDICTED: Bison bison bison fibrous sheath interacting protein 2 (FSIP2), mRNA","Q5CZC0",8491,0,"Fibrous sheath-interacting protein 2",".",".",".",".","pfam13949","ALIX_LYPXL_bnd","ALIX V-shaped domain binding to HIV. The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding.This domain is generally central between an N-terminal Bro1 domain, pfam03097 and a C-terminal proline-rich domain. The retroviruses thus used this domain to hijack the ESCRT system of the cell.",".","GO:0005739|mitochondrion;",".",".","."]
["gene15258",3811,4554,3468,3550.75929204252,887,847,995,1001.53879093903,3.54530381066256,1.82590926282604,{"v":1.09585866583139e-13,"d":"1.10E-13"},{"v":3.12659435948353e-11,"d":"3.13E-11"},"up","yes","DAB2IP","protein_coding","chrNC_037338.1:92474701-92688199:+","gi|221136850|ref|NP_001137554.1|",5426,0,"disabled homolog 2-interacting protein [Bos taurus]","gi|965897331|ref|XM_012160373.2|",5615,0,"PREDICTED: Ovis aries musimon DAB2 interacting protein (DAB2IP), transcript variant X2, mRNA","Q5VWQ8",2073,0,"Disabled homolog 2-interacting protein",".",".",".",".","pfam12004","DUF3498","Domain of unknown function (DUF3498). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 433 to 538 amino acids in length. This domain is found associated with pfam00616, pfam00168. This domain has two conserved sequence motifs: DLQ and PLSFQNP.","GO:0007257|activation of JUN kinase activity;GO:0000185|activation of MAPKKK activity;GO:0001525|angiogenesis;GO:0007049|cell cycle;GO:0021814|cell motility involved in cerebral cortex radial glia guided migration;GO:0044257|cellular protein catabolic process;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071347|cellular response to interleukin-1;GO:0071222|cellular response to lipopolysaccharide;GO:0071356|cellular response to tumor necrosis factor;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0072577|endothelial cell apoptotic process;GO:0008625|extrinsic apoptotic signaling pathway via death domain receptors;GO:0007252|I-kappaB phosphorylation;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0021819|layer formation in cerebral cortex;GO:0000165|MAPK cascade;GO:0016525|negative regulation of angiogenesis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0008285|negative regulation of cell proliferation;GO:1903363|negative regulation of cellular protein catabolic process;GO:0010596|negative regulation of endothelial cell migration;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0010633|negative regulation of epithelial cell migration;GO:0050680|negative regulation of epithelial cell proliferation;GO:0010719|negative regulation of epithelial to mesenchymal transition;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0048147|negative regulation of fibroblast proliferation;GO:0070317|negative regulation of G0 to G1 transition;GO:0034260|negative regulation of GTPase activity;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0043407|negative regulation of MAP kinase activity;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0043553|negative regulation of phosphatidylinositol 3-kinase activity;GO:0014067|negative regulation of phosphatidylinositol 3-kinase signaling;GO:0001933|negative regulation of protein phosphorylation;GO:0071901|negative regulation of protein serine/threonine kinase activity;GO:0046580|negative regulation of Ras protein signal transduction;GO:0034144|negative regulation of toll-like receptor 4 signaling pathway;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0030948|negative regulation of vascular endothelial growth factor receptor signaling pathway;GO:1900747|negative regulation of vascular endothelial growth factor signaling pathway;GO:0048812|neuron projection morphogenesis;GO:0043065|positive regulation of apoptotic process;GO:2001235|positive regulation of apoptotic signaling pathway;GO:0071158|positive regulation of cell cycle arrest;GO:1900006|positive regulation of dendrite development;GO:1903896|positive regulation of IRE1-mediated unfolded protein response;GO:0046330|positive regulation of JNK cascade;GO:0043507|positive regulation of JUN kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:2001224|positive regulation of neuron migration;GO:0010976|positive regulation of neuron projection development;GO:1901800|positive regulation of proteasomal protein catabolic process;GO:0045732|positive regulation of protein catabolic process;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0090129|positive regulation of synapse maturation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0038026|reelin-mediated signaling pathway;GO:0040008|regulation of growth;GO:0043087|regulation of GTPase activity;GO:0043122|regulation of I-kappaB kinase/NF-kappaB signaling;GO:1900744|regulation of p38MAPK cascade;GO:0043254|regulation of protein complex assembly;GO:0043497|regulation of protein heterodimerization activity;GO:0006986|response to unfolded protein;GO:0035148|tube formation;GO:0036324|vascular endothelial growth factor receptor-2 signaling pathway;","GO:1990597|AIP1-IRE1 complex;GO:0030424|axon;GO:0044300|cerebellar mossy fiber;GO:0044301|climbing fiber;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030425|dendrite;GO:0030139|endocytic vesicle;GO:0031235|intrinsic component of the cytoplasmic side of the plasma membrane;GO:0043025|neuronal cell body;GO:0032809|neuronal cell body membrane;GO:1990032|parallel fiber;GO:0005886|plasma membrane;","GO:0071889|14-3-3 protein binding;GO:0045296|cadherin binding;GO:0005123|death receptor binding;GO:0005096|GTPase activator activity;GO:0042802|identical protein binding;GO:0019900|kinase binding;GO:0031434|mitogen-activated protein kinase kinase binding;GO:0031435|mitogen-activated protein kinase kinase kinase binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0036312|phosphatidylinositol 3-kinase regulatory subunit binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;GO:0042803|protein homodimerization activity;GO:0019901|protein kinase binding;GO:0051721|protein phosphatase 2A binding;GO:0044877|macromolecular complex binding;GO:0017124|SH3 domain binding;GO:0035591|signaling adaptor activity;GO:0043184|vascular endothelial growth factor receptor 2 binding;",".","."]
["gene1535",6428,1025,1978,2618.68337884675,32,206,106,125.823144273785,20.812414075018,4.37937241085258,{"v":3.02959708034531e-05,"d":"3.03E-05"},0.00107046222714526,"up","yes","FRZB","protein_coding","chrNC_037329.1:13692422-13730089:+","gi|27806625|ref|NP_776484.1|",1553,0,"secreted frizzled-related protein 3 precursor [Bos taurus]","gi|982913029|ref|XM_005202256.3|",2551,0,"PREDICTED: Bos taurus frizzled-related protein (FRZB), transcript variant X3, mRNA","Q95117",602,0,"Secreted frizzled-related protein 3",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0060070|canonical Wnt signaling pathway;GO:0090103|cochlea morphogenesis;GO:0060029|convergent extension involved in organogenesis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0061037|negative regulation of cartilage development;GO:0010721|negative regulation of cell development;GO:0030308|negative regulation of cell growth;GO:0008285|negative regulation of cell proliferation;GO:0070367|negative regulation of hepatocyte differentiation;GO:0030178|negative regulation of Wnt signaling pathway;GO:0014033|neural crest cell differentiation;GO:0035567|non-canonical Wnt signaling pathway;GO:0043065|positive regulation of apoptotic process;GO:0045600|positive regulation of fat cell differentiation;GO:0061053|somite development;","GO:0005576|extracellular region;GO:0016021|integral component of membrane;","GO:0004930|G-protein coupled receptor activity;GO:0042813|Wnt-activated receptor activity;GO:0017147|Wnt-protein binding;",".","."]
["gene15351",8577,11557,18448,11688.578617737,4026,5151,5348,5325.62630639691,2.19478009632354,1.13407639769392,{"v":6.0458496222206e-05,"d":"6.05E-05"},0.00191805939973421,"up","yes","RPL35","protein_coding","chrNC_037338.1:95849986-95854606:-","gi|926704947|ref|XP_005687185.2|",560,{"v":3e-68,"d":"3.00E-68"},"PREDICTED: 60S ribosomal protein L35 [Capra hircus]","gi|77735940|ref|NM_001034495.1|",922,0,"Bos taurus ribosomal protein L35 (RPL35), mRNA","Q3MHM7",201,{"v":9e-63,"d":"9.00E-63"},"60S ribosomal protein L35","SPCC613.05c",108,{"v":5e-28,"d":"5.00E-28"},"COG0255","pfam00831","Ribosomal_L29","Ribosomal L29 protein.","GO:0000463|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0006412|translation;","GO:0022625|cytosolic large ribosomal subunit;","GO:0003729|mRNA binding;GO:0003735|structural constituent of ribosome;","K02918","RP-L35e, RPL35; large subunit ribosomal protein L35e"]
["gene15365",1234,1757,1927,1489.23242458468,522,569,588,616.174928242009,2.41689876742237,1.27315704662591,{"v":4.39671583261884e-07,"d":"4.40E-07"},{"v":3.00821821152154e-05,"d":"3.01E-05"},"up","yes","MVB12B","protein_coding","chrNC_037338.1:97112145-97306625:+","gi|982991258|ref|XP_015320974.1|",1533,0,"PREDICTED: LOW QUALITY PROTEIN: multivesicular body subunit 12B isoform X3 [Bos taurus]","gi|982991257|ref|XM_015465488.1|",4142,0,"PREDICTED: Bos taurus multivesicular body subunit 12B (MVB12B), transcript variant X3, mRNA","Q9H7P6",591,0,"Multivesicular body subunit 12B",".",".",".",".","pfam10240","DUF2464","Protein of unknown function (DUF2464). This is a family of proteins conserved from worms to humans. Members have been annotated as FAM125A proteins, but their function is unknown.","GO:0016197|endosomal transport;GO:0048524|positive regulation of viral process;GO:0015031|protein transport;GO:0042058|regulation of epidermal growth factor receptor signaling pathway;GO:0043162|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0019058|viral life cycle;GO:0019075|virus maturation;","GO:0005829|cytosol;GO:0005769|early endosome;GO:0010008|endosome membrane;GO:0000813|ESCRT I complex;GO:0070062|extracellular exosome;GO:0005770|late endosome;GO:0031902|late endosome membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0031982|vesicle;","GO:0008289|lipid binding;","K12186","FAM125; ESCRT-I complex subunit MVB12"]
["gene15372",2049,1741,2144,1763.04227423184,522,844,624,730.091533698423,2.41482361163784,1.27191781270119,{"v":7.6920249415667e-05,"d":"7.69E-05"},0.00233967125381492,"up","yes","ANGPTL2","protein_coding","chrNC_037338.1:97835686-97872064:-","gi|157954420|ref|NP_001103284.1|",2214,0,"angiopoietin-related protein 2 precursor [Bos taurus]","gi|982939809|ref|XM_005213249.2|",3744,0,"PREDICTED: Bos taurus angiopoietin like 2 (ANGPTL2), transcript variant X1, mRNA","Q9UKU9",846,0,"Angiopoietin-related protein 2",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0007275|multicellular organismal development;","GO:0070062|extracellular exosome;GO:0005615|extracellular space;","GO:0005102|receptor binding;",".","."]
["gene15388",1441,517,906,823.240324479729,200,196,234,231.150837456966,3.56148536400173,1.83247906151447,{"v":7.60566308822815e-12,"d":"7.61E-12"},{"v":1.57244328674085e-09,"d":"1.57E-09"},"up","yes","SH2D3C","protein_coding","chrNC_037338.1:98421824-98454870:-","gi|148223121|ref|NP_001091508.1|",3917,0,"SH2 domain-containing protein 3C [Bos taurus]","gi|148223120|ref|NM_001098039.1|",3137,0,"Bos taurus SH2 domain containing 3C (SH2D3C), mRNA","Q8N5H7",1358,0,"SH2 domain-containing protein 3C",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0007254|JNK cascade;GO:0007264|small GTPase mediated signal transduction;","GO:0005737|cytoplasm;GO:0016020|membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005070|SH3/SH2 adaptor activity;",".","."]
["gene15392",7674,30062,28427,20582.4182703672,2192,6480,4052,4660.0412447494,4.41678886287927,2.14299786843024,0.0013964907239721,0.0235480359607849,"up","yes","AK1","protein_coding","chrNC_037338.1:98538949-98555122:-","gi|594102989|ref|XP_006074532.1|",1279,{"v":3e-170,"d":"3.00E-170"},"PREDICTED: adenylate kinase isoenzyme 1 isoform X1 [Bubalus bubalis]","gi|942093595|ref|XM_005908447.2|",1836,0,"PREDICTED: Bos mutus adenylate kinase 1 (AK1), transcript variant X1, mRNA","P00570",389,{"v":1e-130,"d":"1.00E-130"},"Adenylate kinase isoenzyme 1","YKL024c",174,{"v":5e-49,"d":"5.00E-49"},"COG0563","pfam00406","ADK","Adenylate kinase.","GO:0046034|ATP metabolic process;GO:0007050|cell cycle arrest;GO:0006165|nucleoside diphosphate phosphorylation;GO:0009142|nucleoside triphosphate biosynthetic process;","GO:0005829|cytosol;GO:0001520|outer dense fiber;GO:0005886|plasma membrane;","GO:0004017|adenylate kinase activity;GO:0005524|ATP binding;GO:0004550|nucleoside diphosphate kinase activity;","K00939","adk, AK; adenylate kinase [EC:2.7.4.3]"]
["gene15400",2091,3223,3497,2675.2016210349,657,509,672,674.936088907674,3.96363695022514,1.98682482476041,{"v":6.80041832793328e-16,"d":"6.80E-16"},{"v":2.73271458189105e-13,"d":"2.73E-13"},"up","yes","SLC25A25","protein_coding","chrNC_037338.1:98712443-98748919:+","gi|555993518|ref|XP_005908520.1|",2526,0,"PREDICTED: calcium-binding mitochondrial carrier protein SCaMC-2 isoform X3 [Bos mutus]","gi|402767355|ref|NM_001038145.2|",3321,0,"Bos taurus solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 (SLC25A25), mRNA","Q0V7M4",977,0,"Calcium-binding mitochondrial carrier protein SCaMC-2",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0060612|adipose tissue development;GO:0046034|ATP metabolic process;GO:0070588|calcium ion transmembrane transport;GO:0043010|camera-type eye development;GO:0045333|cellular respiration;GO:0006839|mitochondrial transport;GO:0035264|multicellular organism growth;GO:0014823|response to activity;GO:0002021|response to dietary excess;GO:0032094|response to food;","GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;","GO:0015217|ADP transmembrane transporter activity;GO:0005347|ATP transmembrane transporter activity;GO:0005509|calcium ion binding;","K14684","SLC25A23S; solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41"]
["gene15429",488,135,185,228.24352848646,109,71,122,110.835531619698,2.05929926216816,1.04215350101115,0.00377672619102476,0.0488120921486671,"up","yes","PKN3","protein_coding","chrNC_037338.1:99211048-99224634:+","gi|741944279|ref|XP_010808695.1|",4215,0,"PREDICTED: serine/threonine-protein kinase N3 isoform X1 [Bos taurus]","gi|982939748|ref|XM_010810393.2|",3485,0,"PREDICTED: Bos taurus protein kinase N3 (PKN3), transcript variant X1, mRNA","Q6P5Z2",1409,0,"Serine/threonine-protein kinase N3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0010631|epithelial cell migration;GO:0035556|intracellular signal transduction;GO:0018105|peptidyl-serine phosphorylation;GO:0006468|protein phosphorylation;GO:0007165|signal transduction;","GO:0005794|Golgi apparatus;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0005524|ATP binding;GO:0017049|GTP-Rho binding;GO:0004672|protein kinase activity;GO:0004697|protein kinase C activity;GO:0004674|protein serine/threonine kinase activity;","K06071","PKN; protein kinase N [EC:2.7.11.13]"]
["gene15489",3013,5999,5271,4370.07430089615,745,878,989,957.674499440727,4.56321464490099,2.19005051699878,{"v":2.93506828124005e-18,"d":"2.94E-18"},{"v":1.64196927709921e-15,"d":"1.64E-15"},"up","yes","FAM78A","protein_coding","chrNC_037338.1:101450824-101465328:-","gi|528969897|ref|XP_005213268.1|",1506,0,"PREDICTED: protein FAM78A isoform X1 [Bos taurus]","gi|741944297|ref|XM_005213211.2|",3741,0,"PREDICTED: Bos taurus family with sequence similarity 78 member A (FAM78A), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["gene15491",1858,8261,6535,5198.55359759628,1191,1538,1659,1608.43869845989,3.23204956618737,1.69244932319626,{"v":9.08715207292758e-11,"d":"9.09E-11"},{"v":1.5161727239339e-08,"d":"1.52E-08"},"up","yes","PLPP7","protein_coding","chrNC_037338.1:101477749-101492970:+","gi|118151304|ref|NP_001071586.1|",1128,{"v":3e-147,"d":"3.00E-147"},"inactive phospholipid phosphatase 7 [Bos taurus]","gi|118151303|ref|NM_001078118.1|",1950,0,"Bos taurus phospholipid phosphatase 7 (inactive) (PLPP7), mRNA","Q8NBV4",412,{"v":3e-138,"d":"3.00E-138"},"Inactive phospholipid phosphatase 7",".",".",".",".","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.","GO:0010832|negative regulation of myotube differentiation;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0005635|nuclear envelope;",".",".","."]
["gene15530",392,1199,856,757.993924577033,138,161,161,168.781630093786,4.49097407197597,2.1670283929392,{"v":1.8518772492266e-14,"d":"1.85E-14"},{"v":5.93661907839149e-12,"d":"5.94E-12"},"up","yes","KCNT1","protein_coding","chrNC_037338.1:103307792-103386983:+","gi|982940113|ref|XP_015329179.1|",6130,0,"PREDICTED: potassium channel subfamily T member 1 isoform X8 [Bos taurus]","gi|982991415|ref|XM_015465529.1|",5841,0,"PREDICTED: Bos taurus potassium channel, sodium activated subfamily T, member 1 (KCNT1), transcript variant X10, mRNA","Q5JUK3",2234,0,"Potassium channel subfamily T member 1","Zkch",58.5,{"v":1e-07,"d":"1.00E-07"},"COG1226","pfam03493","BK_channel_a","Calcium-activated BK potassium channel alpha subunit.",".","GO:0008076|voltage-gated potassium channel complex;","GO:0015269|calcium-activated potassium channel activity;GO:0005249|voltage-gated potassium channel activity;","K04946","KCNT1; potassium channel subfamily T member 1"]
["gene15552",3929,1830,2116,2273.58142719228,829,980,916,1000.15273019609,2.2732342356817,1.18474634814409,{"v":1.30894851680838e-06,"d":"1.31E-06"},{"v":7.73201037951548e-05,"d":"7.73E-05"},"up","yes","NOTCH1","protein_coding","chrNC_037338.1:103934022-103981092:-","gi|982991465|ref|XP_015321034.1|",12159,0,"PREDICTED: neurogenic locus notch homolog protein 1 isoform X2 [Bos taurus]","gi|982991464|ref|XM_015465548.1|",9485,0,"PREDICTED: Bos taurus notch 1 (NOTCH1), transcript variant X2, mRNA","P46531",4298,0,"Neurogenic locus notch homolog protein 1","all2748",88.6,{"v":6e-17,"d":"6.00E-17"},"COG0666","pfam06816","NOD","NOTCH protein. NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.","GO:0031100|organ regeneration;GO:0003180|aortic valve morphogenesis;GO:1902263|apoptotic process involved in embryonic digit morphogenesis;GO:0060842|arterial endothelial cell differentiation;GO:0048708|astrocyte differentiation;GO:0003162|atrioventricular node development;GO:0003181|atrioventricular valve morphogenesis;GO:0009912|auditory receptor cell fate commitment;GO:0007409|axonogenesis;GO:0048754|branching morphogenesis of an epithelial tube;GO:0003209|cardiac atrium morphogenesis;GO:0003207|cardiac chamber formation;GO:0060317|cardiac epithelial to mesenchymal transition;GO:0003214|cardiac left ventricle morphogenesis;GO:0060038|cardiac muscle cell proliferation;GO:0055008|cardiac muscle tissue morphogenesis;GO:0003213|cardiac right atrium morphogenesis;GO:0003219|cardiac right ventricle formation;GO:0060411|cardiac septum morphogenesis;GO:0060948|cardiac vascular smooth muscle cell development;GO:0003208|cardiac ventricle morphogenesis;GO:0007050|cell cycle arrest;GO:0021515|cell differentiation in spinal cord;GO:0001708|cell fate specification;GO:0003273|cell migration involved in endocardial cushion formation;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0060271|cilium morphogenesis;GO:0072044|collecting duct development;GO:0007386|compartment pattern specification;GO:0060982|coronary artery morphogenesis;GO:0003169|coronary vein morphogenesis;GO:0007368|determination of left/right symmetry;GO:0072017|distal tubule development;GO:0035116|embryonic hindlimb morphogenesis;GO:0060956|endocardial cell differentiation;GO:0003203|endocardial cushion morphogenesis;GO:0003157|endocardium development;GO:0003160|endocardium morphogenesis;GO:0007492|endoderm development;GO:0001837|epithelial to mesenchymal transition;GO:0003198|epithelial to mesenchymal transition involved in endocardial cushion formation;GO:0030900|forebrain development;GO:0007440|foregut morphogenesis;GO:0072144|glomerular mesangial cell development;GO:0003241|growth involved in heart morphogenesis;GO:0031069|hair follicle morphogenesis;GO:0007507|heart development;GO:0001947|heart looping;GO:0061384|heart trabecula morphogenesis;GO:0006959|humoral immune response;GO:0006955|immune response;GO:0001701|in utero embryonic development;GO:0002437|inflammatory response to antigenic stimulus;GO:0072602|interleukin-4 secretion;GO:0030216|keratinocyte differentiation;GO:0070986|left/right axis specification;GO:0001889|liver development;GO:0030324|lung development;GO:0014031|mesenchymal cell development;GO:0003192|mitral valve formation;GO:2000811|negative regulation of anoikis;GO:0030514|negative regulation of BMP signaling pathway;GO:0045955|negative regulation of calcium ion-dependent exocytosis;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0043086|negative regulation of catalytic activity;GO:0090051|negative regulation of cell migration involved in sprouting angiogenesis;GO:0008285|negative regulation of cell proliferation;GO:0010812|negative regulation of cell-substrate adhesion;GO:2001027|negative regulation of endothelial cell chemotaxis;GO:0010629|negative regulation of gene expression;GO:0060253|negative regulation of glial cell proliferation;GO:0045967|negative regulation of growth rate;GO:0045608|negative regulation of auditory receptor cell differentiation;GO:0045662|negative regulation of myoblast differentiation;GO:0010832|negative regulation of myotube differentiation;GO:0050768|negative regulation of neurogenesis;GO:0048715|negative regulation of oligodendrocyte differentiation;GO:0030279|negative regulation of ossification;GO:0045668|negative regulation of osteoblast differentiation;GO:0046533|negative regulation of photoreceptor cell differentiation;GO:2000974|negative regulation of pro-B cell differentiation;GO:2000737|negative regulation of stem cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0021915|neural tube development;GO:0097150|neuronal stem cell population maintenance;GO:0061314|Notch signaling involved in heart development;GO:0007219|Notch signaling pathway;GO:0003270|Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation;GO:0048709|oligodendrocyte differentiation;GO:0003344|pericardium morphogenesis;GO:1903849|positive regulation of aorta morphogenesis;GO:0043065|positive regulation of apoptotic process;GO:0048711|positive regulation of astrocyte differentiation;GO:0030513|positive regulation of BMP signaling pathway;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0030335|positive regulation of cell migration;GO:0008284|positive regulation of cell proliferation;GO:0045603|positive regulation of endothelial cell differentiation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0046427|positive regulation of JAK-STAT cascade;GO:0045618|positive regulation of keratinocyte differentiation;GO:0002052|positive regulation of neuroblast proliferation;GO:0045747|positive regulation of Notch signaling pathway;GO:0046579|positive regulation of Ras protein signal transduction;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0061419|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0007221|positive regulation of transcription of Notch receptor target;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045070|positive regulation of viral genome replication;GO:0060740|prostate gland epithelium morphogenesis;GO:0003184|pulmonary valve morphogenesis;GO:0060768|regulation of epithelial cell proliferation involved in prostate gland development;GO:1901201|regulation of extracellular matrix assembly;GO:0014807|regulation of somitogenesis;GO:0003256|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0031960|response to corticosteroid;GO:0032496|response to lipopolysaccharide;GO:0032495|response to muramyl dipeptide;GO:0060528|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0035914|skeletal muscle cell differentiation;GO:0048103|somatic stem cell division;GO:0007283|spermatogenesis;GO:0002040|sprouting angiogenesis;GO:0042246|tissue regeneration;GO:0006367|transcription initiation from RNA polymerase II promoter;GO:0035148|tube formation;GO:0060979|vasculogenesis involved in coronary vascular morphogenesis;GO:0060843|venous endothelial cell differentiation;GO:0060412|ventricular septum morphogenesis;GO:0003222|ventricular trabecula myocardium morphogenesis;","GO:0001669|acrosomal vesicle;GO:0005912|adherens junction;GO:0016324|apical plasma membrane;GO:0009986|cell surface;GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;GO:0005576|extracellular region;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0002193|MAML1-RBP-Jkappa- ICN1 complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0043235|receptor complex;","GO:0005509|calcium ion binding;GO:0031490|chromatin DNA binding;GO:0001047|core promoter binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019899|enzyme binding;GO:0004857|enzyme inhibitor activity;GO:0005112|Notch binding;GO:0046982|protein heterodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0001190|transcriptional activator activity, RNA polymerase II transcription factor binding;GO:0004888|transmembrane signaling receptor activity;","K02599","NOTCH; Notch"]
["gene15598",3457,8217,5210,5193.93441088156,2360,2118,2562,2584.18490417317,2.00989271413741,1.00711849398487,0.000165771610245839,0.00440839386621088,"up","yes","RXRA","protein_coding","chrNC_037338.1:105021652-105114880:+","gi|594077600|ref|XP_006062516.1|",2132,0,"PREDICTED: retinoic acid receptor RXR-alpha isoform X3 [Bubalus bubalis]","gi|982940181|ref|XM_005213506.3|",4798,0,"PREDICTED: Bos taurus retinoid X receptor alpha (RXRA), transcript variant X1, mRNA","P28700",799,0,"Retinoic acid receptor RXR-alpha",".",".",".",".","pfam00104","Hormone_recep","Ligand-binding domain of nuclear hormone receptor. This all helical domain is involved in binding the hormone in these receptors.","GO:0060978|angiogenesis involved in coronary vascular morphogenesis;GO:0043010|camera-type eye development;GO:0055007|cardiac muscle cell differentiation;GO:0060038|cardiac muscle cell proliferation;GO:0007566|embryo implantation;GO:0007507|heart development;GO:0003007|heart morphogenesis;GO:0001701|in utero embryonic development;GO:0001893|maternal placenta development;GO:0060485|mesenchyme development;GO:0019048|modulation by virus of host morphology or physiology;GO:0008285|negative regulation of cell proliferation;GO:0010629|negative regulation of gene expression;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0035357|peroxisome proliferator activated receptor signaling pathway;GO:0001890|placenta development;GO:0043065|positive regulation of apoptotic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1901522|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045994|positive regulation of translational initiation by iron;GO:0051289|protein homotetramerization;GO:0060687|regulation of branching involved in prostate gland morphogenesis;GO:0031641|regulation of myelination;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006355|regulation of transcription, DNA-templated;GO:0051384|response to glucocorticoid;GO:0032526|response to retinoic acid;GO:0048384|retinoic acid receptor signaling pathway;GO:0060528|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development;GO:0006351|transcription, DNA-templated;GO:0055012|ventricular cardiac muscle cell differentiation;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0061032|visceral serous pericardium development;","GO:0030424|axon;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;GO:0043235|receptor complex;GO:0090575|RNA polymerase II transcription factor complex;","GO:0004886|9-cis retinoic acid receptor activity;GO:0031490|chromatin DNA binding;GO:0050692|DBD domain binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0003690|double-stranded DNA binding;GO:0019899|enzyme binding;GO:0050693|LBD domain binding;GO:0016922|ligand-dependent nuclear receptor binding;GO:0004879|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0042277|peptide binding;GO:0019904|protein domain specific binding;GO:0046982|protein heterodimerization activity;GO:0044877|macromolecular complex binding;GO:0001972|retinoic acid binding;GO:0042974|retinoic acid receptor binding;GO:0044323|retinoic acid-responsive element binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0003707|steroid hormone receptor activity;GO:0008134|transcription factor binding;GO:0042809|vitamin D receptor binding;GO:0070644|vitamin D response element binding;GO:0008270|zinc ion binding;","K08524","NR2B1, RXRA; retinoid X receptor alpha"]
["gene15600",7282,5555,8330,6276.6533265894,2102,1624,2228,2185.89593308131,2.87143282148003,1.52177080959045,{"v":1.77892035895298e-09,"d":"1.78E-09"},{"v":2.18829360262923e-07,"d":"2.19E-07"},"up","yes","COL5A1","protein_coding","chrNC_037338.1:105268085-105419602:+","gi|555970992|ref|XP_005897513.1|",2026,0,"PREDICTED: LOW QUALITY PROTEIN: collagen alpha-1(V) chain [Bos mutus]","gi|965804148|ref|XM_012117954.2|",5461,0,"PREDICTED: Ovis aries musimon collagen, type V, alpha 1 (COL5A1), transcript variant X3, mRNA","P20908",679,0,"Collagen alpha-1(V) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001568|blood vessel development;GO:0007155|cell adhesion;GO:0016477|cell migration;GO:0032964|collagen biosynthetic process;GO:0030199|collagen fibril organization;GO:0030198|extracellular matrix organization;GO:0048592|eye morphogenesis;GO:0003007|heart morphogenesis;GO:0045112|integrin biosynthetic process;GO:1903225|negative regulation of endodermal cell differentiation;GO:0051128|regulation of cellular component organization;GO:0043588|skin development;GO:0097435|fibril organization;GO:0035989|tendon development;GO:0035313|wound healing, spreading of epidermal cells;","GO:0005604|basement membrane;GO:0005588|collagen type V trimer;GO:0005788|endoplasmic reticulum lumen;GO:0031012|extracellular matrix;GO:0005576|extracellular region;","GO:0005201|extracellular matrix structural constituent;GO:0008201|heparin binding;GO:0005178|integrin binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;GO:0043394|proteoglycan binding;",".","."]
["gene15605",108,136,90,100.357860975136,9,20,17,16.8402032951579,5.95942098893735,2.5751721667667,{"v":1.06233189747922e-07,"d":"1.06E-07"},{"v":8.91452687264103e-06,"d":"8.91E-06"},"up","yes","OLFM1","protein_coding","chrNC_037338.1:105560462-105581643:+","gi|156120407|ref|NP_001095349.1|",608,{"v":5e-76,"d":"5.00E-76"},"noelin precursor [Bos taurus]","gi|402745119|ref|NM_001101879.2|",884,0,"Bos taurus olfactomedin 1 (OLFM1), mRNA","Q62609",208,{"v":1e-61,"d":"1.00E-61"},"Noelin",".",".",".",".","pfam12308","Noelin-1","Neurogenesis glycoprotein. This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with pfam02191. There are two conserved sequence motifs: SAQ and VQN. Noelin-1 is a glycoprotein which is secreted mainly by postmitotic neurogenic tissues in the developing central and peripheral nervous systems, first appearing after neural tube closure. It is likely that it forms large multimeric complexes.It has a divergent function in neurogenesis. In animal caps neuralized by expression of noggin, co-expression of Noelin-1 causes expression of neuronal differentiation markers several stages before neurogenesis normally occurs in this tissue. Finally, only secreted forms of the protein can activate sensory marker expression, while all forms of the protein can induce early neurogenesis.","GO:0003190|atrioventricular valve formation;GO:0060317|cardiac epithelial to mesenchymal transition;GO:0010629|negative regulation of gene expression;GO:0023041|neuronal signal transduction;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0010628|positive regulation of gene expression;GO:0030516|regulation of axon extension;","GO:0030424|axon;GO:0044295|axonal growth cone;GO:0005623|cell;GO:0030054|cell junction;GO:0005783|endoplasmic reticulum;GO:0005615|extracellular space;GO:0043025|neuronal cell body;GO:0043204|perikaryon;GO:0045202|synapse;",".",".","."]
["gene15625",266,112,156,153.941135912434,44,61,38,52.5490074377142,2.92947751857918,1.55064337844602,{"v":6.31031020926117e-05,"d":"6.31E-05"},0.00197845561077396,"up","yes","C8G","protein_coding","chrNC_037338.1:105985405-105987650:+","gi|158519861|ref|NP_001103546.1|",884,{"v":1e-112,"d":"1.00E-112"},"complement component C8 gamma chain precursor [Bos taurus]","gi|402693338|ref|NM_001110076.2|",1048,0,"Bos taurus complement component 8, gamma polypeptide (C8G), mRNA","P07360",208,{"v":5e-62,"d":"5.00E-62"},"Complement component C8 gamma chain",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0006957|complement activation, alternative pathway;GO:0006958|complement activation, classical pathway;GO:0019835|cytolysis;GO:0030449|regulation of complement activation;","GO:0072562|blood microparticle;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005579|membrane attack complex;","GO:0001848|complement binding;GO:0044877|macromolecular complex binding;GO:0019841|retinol binding;","K03999","C8G; complement component 8 subunit gamma"]
["gene15652",59,129,147,102.799231731378,32,23,46,37.0060458415226,2.77790370177924,1.47399658802573,0.0010116873511089,0.0182340188341681,"up","yes","RNF208","protein_coding","chrNC_037338.1:106236179-106238497:-","gi|982991568|ref|XP_003585015.2|",1214,{"v":1e-157,"d":"1.00E-157"},"PREDICTED: RING finger protein 208 isoform X2 [Bos taurus]","gi|965899010|ref|XM_012161066.2|",1383,0,"PREDICTED: Ovis aries musimon RING finger protein 208 (LOC105612426), mRNA","Q8K0W3",420,{"v":9e-141,"d":"9.00E-141"},"RING finger protein 208",".",".",".",".","pfam14634","zf-RING_5","zinc-RING finger domain.","GO:0051865|protein autoubiquitination;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0046872|metal ion binding;GO:0004842|ubiquitin-protein transferase activity;",".","."]
["gene15662",321,188,194,204.852579635235,64,74,71,76.7073129572316,2.67057431342238,1.4171500303129,{"v":6.67918165092964e-05,"d":"6.68E-05"},0.00207134490959428,"up","yes","NRARP","protein_coding","chrNC_037338.1:106324461-106326930:-","gi|795540420|ref|XP_011904291.1|",598,{"v":2e-68,"d":"2.00E-68"},"PREDICTED: notch-regulated ankyrin repeat-containing protein [Cercocebus atys]","gi|965899067|ref|XM_012161089.2|",2226,0,"PREDICTED: Ovis aries musimon notch-regulated ankyrin repeat-containing protein (LOC105612429), transcript variant X2, mRNA","Q91ZA8",229,{"v":5e-69,"d":"5.00E-69"},"Notch-regulated ankyrin repeat-containing protein",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0002043|blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0001569|patterning of blood vessels;GO:0045746|negative regulation of Notch signaling pathway;GO:1902367|negative regulation of Notch signaling pathway involved in somitogenesis;GO:0045581|negative regulation of T cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0007219|Notch signaling pathway;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0001938|positive regulation of endothelial cell proliferation;GO:0060828|regulation of canonical Wnt signaling pathway;GO:0022407|regulation of cell-cell adhesion;GO:0032525|somite rostral/caudal axis specification;GO:0002040|sprouting angiogenesis;",".",".",".","."]
["gene15767",0,35,5,13.0057269402712,0,0,0,0,"Inf","Inf",{"v":9.31598448491444e-05,"d":"9.32E-05"},0.00275434563045693,"up","yes","SPERT","protein_coding","chrNC_037339.1:15768622-15782386:+","gi|528971050|ref|XP_005213736.1|",2111,0,"PREDICTED: spermatid-associated protein isoform X1 [Bos taurus]","gi|965817622|ref|XM_012124405.2|",1515,0,"PREDICTED: Ovis aries musimon spermatid associated (SPERT), transcript variant X2, mRNA","A6QQS3",817,0,"Spermatid-associated protein",".",".",".",".","pfam14645","Chibby","Chibby family. This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila.",".","GO:0031410|cytoplasmic vesicle;",".",".","."]
["gene15859",13592,12714,10339,10884.3241783846,1808,1371,1614,1761.52290610233,6.17892855135675,2.62735669125945,{"v":1.09773589355373e-23,"d":"1.10E-23"},{"v":1.36171751212963e-20,"d":"1.36E-20"},"up","yes","FOXO1","protein_coding","chrNC_037339.1:21900254-21993948:+","gi|803252374|ref|XP_011986126.1|",2662,0,"PREDICTED: forkhead box protein O1 isoform X2 [Ovis aries musimon]","gi|982991741|ref|XM_015465638.1|",5664,0,"PREDICTED: Bos taurus forkhead box O1 (FOXO1), transcript variant X2, mRNA","A4L7N3",995,0,"Forkhead box protein O1","ECU01g0470",77,{"v":3e-14,"d":"3.00E-14"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0009653|anatomical structure morphogenesis;GO:0006915|apoptotic process;GO:0006914|autophagy;GO:0030154|cell differentiation;GO:0006974|cellular response to DNA damage stimulus;GO:0071455|cellular response to hyperoxia;GO:0032869|cellular response to insulin stimulus;GO:0071732|cellular response to nitric oxide;GO:0034599|cellular response to oxidative stress;GO:0009267|cellular response to starvation;GO:0008286|insulin receptor signaling pathway;GO:0045599|negative regulation of fat cell differentiation;GO:0010629|negative regulation of gene expression;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0043065|positive regulation of apoptotic process;GO:0010508|positive regulation of autophagy;GO:1903661|positive regulation of complement-dependent cytotoxicity;GO:0045732|positive regulation of protein catabolic process;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0051721|protein phosphatase 2A binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;",".","."]
["gene15978",516,1626,1490,1124.96177067347,107,251,179,196.721212499263,5.71855854476133,2.51565153819275,{"v":2.59968587649018e-06,"d":"2.60E-06"},0.000135349703909017,"up","yes","SHISA2","protein_coding","chrNC_037339.1:33338091-33343673:+","gi|155372245|ref|NP_001094735.1|",1185,{"v":1e-152,"d":"1.00E-152"},"protein shisa-2 homolog precursor [Bos taurus]","gi|155372244|ref|NM_001101265.1|",2627,0,"Bos taurus shisa family member 2 (SHISA2), mRNA","A6QPA0",461,{"v":4e-154,"d":"4.00E-154"},"Protein shisa-2 homolog",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.","GO:0007275|multicellular organismal development;GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;GO:0030178|negative regulation of Wnt signaling pathway;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["gene16033",0,45,0,14.7472955642966,0,0,0,0,"Inf","Inf",{"v":3.37191327560205e-05,"d":"3.37E-05"},0.00116610978989336,"up","yes","RNF17","protein_coding","chrNC_037339.1:36524149-36634812:-","gi|528912714|ref|XP_606484.6|",8411,0,"PREDICTED: RING finger protein 17 [Bos taurus]","gi|741887213|ref|XM_606484.7|",5028,0,"PREDICTED: Bos taurus ring finger protein 17 (RNF17), mRNA","Q9BXT8",2504,0,"RING finger protein 17",".",".",".",".","pfam00567","TUDOR","Tudor domain.","GO:0007275|multicellular organismal development;GO:0007286|spermatid development;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0042803|protein homodimerization activity;","K18405","TDRD1_4_6_7; tudor domain-containing protein 1/4/6/7"]
["gene16049",1125,258,314,474.188495628983,92,130,93,115.665526891789,4.09965275196135,2.0355017160138,{"v":4.18934887111433e-11,"d":"4.19E-11"},{"v":7.42399457402255e-09,"d":"7.42E-09"},"up","yes","DACH1","protein_coding","chrNC_037339.1:46070254-46548380:-","gi|594065632|ref|XP_006056805.1|",2448,0,"PREDICTED: dachshund homolog 1-like [Bubalus bubalis]","gi|594065631|ref|XM_006056743.1|",4517,0,"PREDICTED: Bubalus bubalis dachshund homolog 1-like (LOC102416212), mRNA","Q9UI36",925,0,"Dachshund homolog 1",".",".",".",".","pfam02437","Ski_Sno","SKI/SNO/DAC family. This family contains a presumed domain that is about 100 amino acids long. All members of this family contain a conserved CLPQ motif. The c-ski proto-oncogene has been shown to influence proliferation, morphological transformation and myogenic differentiation. Sno, a Ski proto-oncogene homologue, is expressed in two isoforms and plays a role in the response to proliferation stimuli. Dachshund also contains this domain. It is involved in various aspects of development.","GO:0008283|cell proliferation;GO:0046545|development of primary female sexual characteristics;GO:0007275|multicellular organismal development;GO:0030336|negative regulation of cell migration;GO:0060244|negative regulation of cell proliferation involved in contact inhibition;GO:2000279|negative regulation of DNA biosynthetic process;GO:0048147|negative regulation of fibroblast proliferation;GO:0010944|negative regulation of transcription by competitive promoter binding;GO:0045892|negative regulation of transcription, DNA-templated;GO:0033262|regulation of nuclear cell cycle DNA replication;GO:0007585|respiratory gaseous exchange;GO:0001967|suckling behavior;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003677|DNA binding;GO:0001075|transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;",".","."]
["gene1605",262,665,699,500.893566615534,162,189,214,207.15927927795,2.41791518275884,1.27376363765594,{"v":2.0625447693302e-05,"d":"2.06E-05"},0.000779423375016689,"up","yes","HOXD9","protein_coding","chrNC_037329.1:20788518-20793616:-","gi|478504828|ref|XP_004426711.1|",825,{"v":1e-95,"d":"1.00E-95"},"PREDICTED: homeobox protein Hox-D9 [Ceratotherium simum simum]","gi|982977206|ref|XM_002703599.4|",4735,0,"PREDICTED: Bos taurus homeobox D9 (HOXD9), mRNA","P28357",275,{"v":1e-80,"d":"1.00E-80"},"Homeobox protein Hox-D9",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0008344|adult locomotory behavior;GO:0009952|anterior/posterior pattern specification;GO:0035115|embryonic forelimb morphogenesis;GO:0048706|embryonic skeletal system development;GO:0048704|embryonic skeletal system morphogenesis;GO:0035136|forelimb morphogenesis;GO:0035137|hindlimb morphogenesis;GO:0030879|mammary gland development;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0048935|peripheral nervous system neuron development;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0009954|proximal/distal pattern formation;GO:0010468|regulation of gene expression;GO:0007338|single fertilization;GO:0007519|skeletal muscle tissue development;GO:0006351|transcription, DNA-templated;","GO:0005730|nucleolus;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09294","HOX_9; homeobox protein HoxA/B/C/D9"]
["gene16203",468,286,310,310.906637510944,147,136,121,148.531938142585,2.09319720323372,1.06570823645035,0.000694472724348529,0.0137447642062416,"up","yes","RAP2A","protein_coding","chrNC_037339.1:74633725-74673056:+","gi|686744183|ref|XP_009247013.1|",896,{"v":8e-113,"d":"8.00E-113"},"PREDICTED: ras-related protein Rap-2a [Pongo abelii]","gi|300793922|ref|NM_001192942.1|",2158,0,"Bos taurus RAP2A, member of RAS oncogene family (RAP2A), mRNA","Q5R988",348,{"v":4e-114,"d":"4.00E-114"},"Ras-related protein Rap-2a",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0031532|actin cytoskeleton reorganization;GO:0034613|cellular protein localization;GO:0031954|positive regulation of protein autophosphorylation;GO:0032486|Rap protein signal transduction;GO:0048814|regulation of dendrite morphogenesis;GO:0046328|regulation of JNK cascade;","GO:0030496|midbody;GO:0055038|recycling endosome membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;",".","."]
["gene16207",1547,2381,1612,1678.56001495277,486,564,514,574.172345404866,2.92344281013598,1.54766836886434,{"v":6.73032886729508e-10,"d":"6.73E-10"},{"v":9.36697623964858e-08,"d":"9.37E-08"},"up","yes","FARP1","protein_coding","chrNC_037339.1:75150004-75458745:+","gi|300794439|ref|NP_001179641.1|",5100,0,"FERM, RhoGEF and pleckstrin domain-containing protein 1 [Bos taurus]","gi|982941842|ref|XM_005213945.3|",4603,0,"PREDICTED: Bos taurus FERM, ARH/RhoGEF and pleckstrin domain protein 1 (FARP1), transcript variant X1, mRNA","Q9Y4F1",1818,0,"FERM, ARHGEF and pleckstrin domain-containing protein 1",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0048813|dendrite morphogenesis;GO:0010923|negative regulation of phosphatase activity;GO:0035023|regulation of Rho protein signal transduction;GO:0007416|synapse assembly;","GO:0030054|cell junction;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0030425|dendrite;GO:0043197|dendritic spine;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0030175|filopodium;","GO:0008092|cytoskeletal protein binding;GO:0030676|Rac guanyl-nucleotide exchange factor activity;GO:0005089|Rho guanyl-nucleotide exchange factor activity;","K17477","FARP1; FERM, RhoGEF and pleckstrin domain-containing protein 1"]
["gene16254",1027,457,837,674.487850958183,262,160,224,237.503177680277,2.83991084896627,1.50584564107748,{"v":3.93643708991768e-06,"d":"3.94E-06"},0.000191656120499046,"up","yes","METTL21E","protein_coding","chrNC_037339.1:79112916-79128997:+","gi|151554465|gb|AAI49819.1|",1560,0,"Similar to RIKEN cDNA 4832428D23 [Bos taurus]","gi|62460539|ref|NM_001014922.1|",1499,0,"Bos taurus RIKEN cDNA 4832428D23-like (METTL21E), mRNA","Q58DC7",602,0,"Protein-lysine methyltransferase METTL21E",".",".",".",".","pfam10294","Methyltransf_16","Putative methyltransferase.",".",".","GO:0008168|methyltransferase activity;",".","."]
["gene16264",2082,694,969,1067.65451142862,477,468,476,521.860656208993,2.04586128255863,1.03270832800147,{"v":8.70168955636909e-05,"d":"8.70E-05"},0.00259259673823368,"up","yes","EFNB2","protein_coding","chrNC_037339.1:82239364-82289093:-","gi|594098343|ref|XP_006072338.1|",1578,0,"PREDICTED: ephrin-B2 [Bubalus bubalis]","gi|982992334|ref|XM_015465828.1|",4215,0,"PREDICTED: Bos taurus ephrin-B2 (EFNB2), mRNA","P52799",590,0,"Ephrin-B2",".",".",".",".","pfam00812","Ephrin","Ephrin.","GO:0009653|anatomical structure morphogenesis;GO:0007411|axon guidance;GO:0007155|cell adhesion;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0007267|cell-cell signaling;GO:0048013|ephrin receptor signaling pathway;GO:0010977|negative regulation of neuron projection development;GO:2000727|positive regulation of cardiac muscle cell differentiation;GO:0008284|positive regulation of cell proliferation;GO:1901216|positive regulation of neuron death;GO:0050920|regulation of chemotaxis;","GO:0005925|focal adhesion;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0046875|ephrin receptor binding;GO:0004713|protein tyrosine kinase activity;GO:0001618|virus receptor activity;","K05463","EFNB; ephrin-B"]
["gene16284",35193,13734,25312,21446.8509700884,9070,6750,9686,9363.62606621375,2.29044291372055,1.19562660602615,{"v":6.28745768533865e-05,"d":"6.29E-05"},0.00197563276674446,"up","yes","COL4A1","protein_coding","chrNC_037339.1:84863917-84995777:-","gi|296481578|tpg|DAA23693.1|",1817,0,"TPA: collagen alpha-1(IV) chain [Bos taurus]","gi|262073078|ref|NM_001166511.1|",5761,0,"Bos taurus collagen, type IV, alpha 1 (COL4A1), mRNA","Q7SIB2",704,0,"Collagen alpha-1(IV) chain",".",".",".",".","pfam01413","C4","C-terminal tandem repeated domain in type 4 procollagen. Duplicated domain in C-terminus of type 4 collagens. Mutations in alpha-5 collagen IV are associated with X-linked Alport syndrome.","GO:0071711|basement membrane organization;GO:0007420|brain development;GO:0001569|patterning of blood vessels;GO:0071230|cellular response to amino acid stimulus;GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0007528|neuromuscular junction development;GO:0061333|renal tubule morphogenesis;GO:0061304|retinal blood vessel morphogenesis;","GO:0005587|collagen type IV trimer;","GO:0005201|extracellular matrix structural constituent;GO:0048407|platelet-derived growth factor binding;",".","."]
["gene16285",17337,8066,13280,11240.3711518254,4957,3660,5440,5159.63543873347,2.17852041782714,1.12334863474031,{"v":3.35819825506523e-05,"d":"3.36E-05"},0.00116610978989336,"up","yes","COL4A2","protein_coding","chrNC_037339.1:84996073-85154028:+","gi|982941926|ref|XP_015329422.1|",2977,0,"PREDICTED: LOW QUALITY PROTEIN: collagen alpha-2(IV) chain isoform X1, partial [Bos taurus]","gi|982992342|ref|XM_015465832.1|",5871,0,"PREDICTED: Bos taurus collagen type IV alpha 2 (COL4A2), transcript variant X2, mRNA","P08122",1006,0,"Collagen alpha-2(IV) chain",".",".",".",".","pfam01413","C4","C-terminal tandem repeated domain in type 4 procollagen. Duplicated domain in C-terminus of type 4 collagens. Mutations in alpha-5 collagen IV are associated with X-linked Alport syndrome.","GO:0007568|aging;GO:0001525|angiogenesis;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0035987|endodermal cell differentiation;GO:0016525|negative regulation of angiogenesis;GO:0014823|response to activity;GO:0006351|transcription, DNA-templated;","GO:0005604|basement membrane;GO:0005587|collagen type IV trimer;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005201|extracellular matrix structural constituent;","K06237","COL4A; collagen, type IV, alpha"]
["gene16431",604,683,778,620.188240894277,167,264,240,245.937482502867,2.52173127325985,1.33441454394858,{"v":6.1267232259831e-06,"d":"6.13E-06"},0.000280580321605977,"up","yes","CAMK1D","protein_coding","chrNC_037340.1:11668382-12062761:-","gi|829771172|ref|XP_012621152.1|",1808,0,"PREDICTED: calcium/calmodulin-dependent protein kinase type 1D isoform X6 [Microcebus murinus]","gi|982992484|ref|XM_015465865.1|",6639,0,"PREDICTED: Bos taurus calcium/calmodulin dependent protein kinase ID (CAMK1D), transcript variant X2, mRNA","Q8BW96",676,0,"Calcium/calmodulin-dependent protein kinase type 1D",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006954|inflammatory response;GO:0035556|intracellular signal transduction;GO:0043066|negative regulation of apoptotic process;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0043065|positive regulation of apoptotic process;GO:0032793|positive regulation of CREB transcription factor activity;GO:0010976|positive regulation of neuron projection development;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0050766|positive regulation of phagocytosis;GO:0060267|positive regulation of respiratory burst;GO:0050773|regulation of dendrite development;GO:0071622|regulation of granulocyte chemotaxis;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0004683|calmodulin-dependent protein kinase activity;","K08794","CAMK1; calcium/calmodulin-dependent protein kinase I [EC:2.7.11.17]"]
["gene16446",484,641,259,415.75318210465,182,189,156,193.69821355136,2.14639657476454,1.10191665744954,0.000295391426372048,0.00691938652366247,"up","yes","USP6NL","protein_coding","chrNC_037340.1:12568065-12779550:+","gi|528972285|ref|XP_005214144.1|",4089,0,"PREDICTED: USP6 N-terminal-like protein isoform X1 [Bos taurus]","gi|982942082|ref|XM_015473959.1|",4802,0,"PREDICTED: Bos taurus USP6 N-terminal like (USP6NL), transcript variant X4, mRNA","Q92738",1244,0,"USP6 N-terminal-like protein","ECU11g1700",135,{"v":1e-32,"d":"1.00E-32"},"COG5210","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0090630|activation of GTPase activity;GO:0007030|Golgi organization;GO:0006886|intracellular protein transport;GO:0048227|plasma membrane to endosome transport;GO:0043547|positive regulation of GTPase activity;GO:1903358|regulation of Golgi organization;GO:0031338|regulation of vesicle fusion;GO:0035526|retrograde transport, plasma membrane to Golgi;GO:0019068|virion assembly;","GO:0031410|cytoplasmic vesicle;GO:0005829|cytosol;GO:0012505|endomembrane system;GO:0005886|plasma membrane;GO:0032588|trans-Golgi network membrane;","GO:0005096|GTPase activator activity;GO:0017137|Rab GTPase binding;",".","."]
["gene16476",8678,94939,36120,44468.1106013839,704,2023,1340,1489.25225808315,29.8593541557692,4.90011105586063,{"v":6.5746689748354e-12,"d":"6.57E-12"},{"v":1.37927853324286e-09,"d":"1.38E-09"},"up","yes","PFKFB3","protein_coding","chrNC_037340.1:17206135-17372368:-","gi|635051484|ref|XP_008000389.1|",2817,0,"PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X3 [Chlorocebus sabaeus]","gi|402745474|ref|NM_001077837.2|",4358,0,"Bos taurus 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), mRNA","Q5R9C1",1050,0,"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3","YJL155c_2",240,{"v":3e-70,"d":"3.00E-70"},"COG0406","pfam01591","6PF2K","6-phosphofructo-2-kinase. This enzyme occurs as a bifunctional enzyme with fructose-2,6-bisphosphatase. The bifunctional enzyme catalyses both the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis. This enzyme contains a P-loop motif.","GO:0006003|fructose 2,6-bisphosphate metabolic process;GO:0006000|fructose metabolic process;",".","GO:0003873|6-phosphofructo-2-kinase activity;GO:0005524|ATP binding;GO:0004331|fructose-2,6-bisphosphate 2-phosphatase activity;","K01103","PFKFB3; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3&#160; [EC:2.7.1.105 3.1.3.46]"]
["gene16497",5062,2199,2596,2837.21376228683,1003,1199,1105,1213.78253141461,2.33749760674194,1.22496488789084,{"v":6.36413442470394e-07,"d":"6.36E-07"},{"v":4.13610750048355e-05,"d":"4.14E-05"},"up","yes","CREM","protein_coding","chrNC_037340.1:18226126-18292979:-","gi|742202138|ref|XP_010858152.1|",1651,0,"PREDICTED: cAMP-responsive element modulator isoform X1 [Bison bison bison]","gi|742202137|ref|XM_010859850.1|",2314,0,"PREDICTED: Bison bison bison cAMP responsive element modulator (CREM), transcript variant X1, mRNA","P79145",618,0,"cAMP-responsive element modulator",".",".",".",".","pfam02173","pKID","pKID domain. CBP and P300 bind to the pKID (phosphorylated kinase-inducible-domain) domain of CREB.","GO:0006687|glycosphingolipid metabolic process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;","K09052","CREM; cAMP response element modulator"]
["gene16517",638,179,387,343.795161885818,107,132,87,119.840186051821,2.86878027490006,1.52043747370037,{"v":1.43109511627103e-06,"d":"1.43E-06"},{"v":8.3157993405965e-05,"d":"8.32E-05"},"up","yes","NEBL","protein_coding","chrNC_037340.1:22094459-22474650:-","gi|329665011|ref|NP_001178342.1|",5100,0,"nebulette [Bos taurus]","gi|619534149|ref|NM_001191413.2|",8979,0,"Bos taurus nebulette (NEBL), mRNA","O76041",1805,0,"Nebulette",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0071691|cardiac muscle thin filament assembly;","GO:0070062|extracellular exosome;GO:0031674|I band;GO:0001725|stress fiber;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0008092|cytoskeletal protein binding;GO:0031005|filamin binding;GO:0008307|structural constituent of muscle;GO:0005523|tropomyosin binding;",".","."]
["gene1654",6370,1049,1969,2608.66836070873,977,1094,990,1124.01898415379,2.32084012591001,1.21464714418136,{"v":3.08539469774457e-06,"d":"3.09E-06"},0.000156357719576111,"up","yes","ITGA6","protein_coding","chrNC_037329.1:24091589-24179355:-","gi|528938921|ref|XP_005202398.1|",5747,0,"PREDICTED: integrin alpha-6 isoform X1 [Bos taurus]","gi|982913222|ref|XM_005202341.3|",5440,0,"PREDICTED: Bos taurus integrin subunit alpha 6 (ITGA6), transcript variant X1, mRNA","P23229",2064,0,"Integrin alpha-6",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0097186|amelogenesis;GO:0050873|brown fat cell differentiation;GO:0033627|cell adhesion mediated by integrin;GO:0098609|cell-cell adhesion;GO:0007160|cell-matrix adhesion;GO:0031589|cell-substrate adhesion;GO:0007044|cell-substrate junction assembly;GO:0031668|cellular response to extracellular stimulus;GO:0071407|cellular response to organic cyclic compound;GO:0048565|digestive tract development;GO:0010668|ectodermal cell differentiation;GO:0030198|extracellular matrix organization;GO:0046847|filopodium assembly;GO:0031581|hemidesmosome assembly;GO:0007229|integrin-mediated signaling pathway;GO:0050900|leukocyte migration;GO:0035878|nail development;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:0043065|positive regulation of apoptotic process;GO:0030335|positive regulation of cell migration;GO:0022409|positive regulation of cell-cell adhesion;GO:0010811|positive regulation of cell-substrate adhesion;GO:0043547|positive regulation of GTPase activity;GO:0042327|positive regulation of phosphorylation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0072001|renal system development;GO:0043588|skin development;","GO:0009925|basal plasma membrane;GO:0005604|basement membrane;GO:0009986|cell surface;GO:0005913|cell-cell adherens junction;GO:0009897|external side of plasma membrane;GO:0030175|filopodium;GO:0005925|focal adhesion;GO:0030056|hemidesmosome;GO:0034676|integrin alpha6-beta4 complex;GO:0005886|plasma membrane;","GO:0045296|cadherin binding;GO:0031994|insulin-like growth factor I binding;GO:0005178|integrin binding;GO:0043236|laminin binding;GO:0046872|metal ion binding;GO:0038132|neuregulin binding;","K06485","ITGA6; integrin alpha 6"]
["gene16542",0,40,0,13.1087071682637,0,0,0,0,"Inf","Inf",{"v":9.14702471430466e-05,"d":"9.15E-05"},0.00271282497010214,"up","yes","ARMC3","protein_coding","chrNC_037340.1:23964717-24057072:+","gi|528972559|ref|XP_005214253.1|",3905,0,"PREDICTED: armadillo repeat-containing protein 3 isoform X1 [Bos taurus]","gi|741946897|ref|XM_005214196.2|",3641,0,"PREDICTED: Bos taurus armadillo repeat containing 3 (ARMC3), transcript variant X1, mRNA","Q5W041",1302,0,"Armadillo repeat-containing protein 3",".",".",".",".","pfam14381","EDR1","Ethylene-responsive protein kinase Le-CTR1. EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signalling and cell death regulation.",".","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0005634|nucleus;",".",".","."]
["gene1662",8709,8825,4996,6696.25597011081,1513,2532,1843,2159.99667855033,3.10012327176584,1.63232558325092,{"v":1.69578625682774e-06,"d":"1.70E-06"},{"v":9.6379437636558e-05,"d":"9.64E-05"},"up","yes","SLC25A12","protein_coding","chrNC_037329.1:24637412-24736034:+","gi|528938931|ref|XP_005202403.1|",3492,0,"PREDICTED: calcium-binding mitochondrial carrier protein Aralar1 isoform X1 [Bos taurus]","gi|741916207|ref|XM_005202346.2|",2998,0,"PREDICTED: Bos taurus solute carrier family 25 (aspartate/glutamate carrier), member 12 (SLC25A12), transcript variant X1, mRNA","Q5RBC8",1281,0,"Calcium-binding mitochondrial carrier protein Aralar1",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0015810|aspartate transport;GO:0006754|ATP biosynthetic process;GO:0045333|cellular respiration;GO:0015813|L-glutamate transport;GO:0043490|malate-aspartate shuttle;GO:0051592|response to calcium ion;","GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;GO:0005739|mitochondrion;","GO:0005509|calcium ion binding;GO:0042802|identical protein binding;GO:0015183|L-aspartate transmembrane transporter activity;GO:0005313|L-glutamate transmembrane transporter activity;","K15105","SLC25A12_13, AGC; solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13"]
["gene16635",2848,1134,1326,1521.13011289415,661,583,675,704.671160038993,2.15863824029633,1.11012148668575,{"v":1.17145682968959e-05,"d":"1.17E-05"},0.000492236153282379,"up","yes","JCAD","protein_coding","chrNC_037340.1:35027159-35112073:-","gi|126723084|ref|NP_001075943.1|",6041,0,"junctional protein associated with coronary artery disease homolog [Bos taurus]","gi|126723083|ref|NM_001082474.1|",3938,0,"Bos taurus KIAA1462 ortholog (KIAA1462), mRNA","A2VE02",2328,0,"Junctional protein associated with coronary artery disease homolog",".",".",".",".","pfam15351","JCAD","Junctional protein associated with coronary artery disease. JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organisation and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.","GO:0007155|cell adhesion;","GO:0005912|adherens junction;GO:0005911|cell-cell junction;",".",".","."]
["gene16644",2156,892,699,1068.90589036321,466,526,461,533.619892891548,2.00312226849543,1.00225048443988,0.000159879806591747,0.00428715297168151,"up","yes","MPP7","protein_coding","chrNC_037340.1:36304106-36527703:+","gi|154152015|ref|NP_001093817.1|",2827,0,"MAGUK p55 subfamily member 7 [Bos taurus]","gi|154152014|ref|NM_001100347.1|",3275,0,"Bos taurus membrane protein, palmitoylated 7 (MPP7), mRNA","A6QQZ7",1092,0,"MAGUK p55 subfamily member 7","YDR454c",100,{"v":2e-22,"d":"2.00E-22"},"COG0194","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0070830|bicellular tight junction assembly;GO:0031334|positive regulation of protein complex assembly;GO:0071896|protein localization to adherens junction;","GO:0005923|bicellular tight junction;GO:0097025|MPP7-DLG1-LIN7 complex;GO:0005654|nucleoplasm;","GO:0019904|protein domain specific binding;GO:0046982|protein heterodimerization activity;GO:0032947|protein complex scaffold;",".","."]
["gene16721",1978,567,709,919.077924800308,218,282,269,282.07364510925,3.25829066534854,1.70411530943496,{"v":3.80029853345777e-10,"d":"3.80E-10"},{"v":5.67677054754364e-08,"d":"5.68E-08"},"up","yes","CD93","protein_coding","chrNC_037340.1:41878369-41881876:-","gi|555953798|ref|XP_005889069.1|",3026,0,"PREDICTED: complement component C1q receptor [Bos mutus]","gi|982992952|ref|XM_003582935.4|",3242,0,"PREDICTED: Bos taurus CD93 molecule (CD93), mRNA","Q9NPY3",750,0,"Complement component C1q receptor",".",".",".",".","pfam07645","EGF_CA","Calcium-binding EGF domain.","GO:0098609|cell-cell adhesion;GO:0042116|macrophage activation;GO:0043312|neutrophil degranulation;GO:0006909|phagocytosis;GO:0016032|viral process;","GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;GO:0035579|specific granule membrane;GO:0070821|tertiary granule membrane;","GO:0005509|calcium ion binding;GO:0030246|carbohydrate binding;GO:0001849|complement component C1q binding;GO:0038023|signaling receptor activity;","K06702","CDW93; CDW93 antigen"]
["gene16763",45,61,163,81.7796503673522,26,27,15,25.0412280343206,3.26580031359755,1.70743658043119,0.000586999987270986,0.0119726941326202,"up","yes","LOC782061","protein_coding","chrNC_037340.1:43287946-43408041:+","gi|528973184|ref|XP_005214489.1|",1684,0,"PREDICTED: prostaglandin F synthase 1-like isoform X2 [Bos taurus]","gi|982993007|ref|XM_015465994.1|",2424,0,"PREDICTED: Bos taurus prostaglandin F synthase 1-like (LOC107131313), transcript variant X4, mRNA","P52898",543,0,"Dihydrodiol dehydrogenase 3","YHR104w",206,{"v":1e-58,"d":"1.00E-58"},"COG0656","pfam00248","Aldo_ket_red","Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.",".","GO:0005737|cytoplasm;","GO:0016491|oxidoreductase activity;","K04119","AKR1C3; aldo-keto reductase family 1 member C3 [EC:1.1.1.64 1.1.1.188 1.1.1.213]"]
["gene16825",484,6,28,136.707358444993,1,1,0,0.740755659174328,184.551217060389,7.52787744153434,{"v":1.91732985481538e-26,"d":"1.92E-26"},{"v":3.64688920584918e-23,"d":"3.65E-23"},"up","yes","PRND","protein_coding","chrNC_037340.1:47086007-47091045:+","gi|62912000|gb|AAY21625.1|",957,{"v":2e-118,"d":"2.00E-118"},"prion-like protein doppel preproprotein [Bos taurus]","gi|31342712|ref|NM_174158.2|",3295,0,"Bos taurus prion protein 2 (dublet) (PRND), mRNA","Q9GK16",371,{"v":3e-119,"d":"3.00E-119"},"Prion-like protein doppel",".",".",".",".","pfam00377","Prion","Prion/Doppel alpha-helical domain. The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the other is the infectious form which can change the normal prion protein into the infectious form. It has been found that the prion alpha-helical domain is also found in the Doppel protein.","GO:0007340|acrosome reaction;GO:0006878|cellular copper ion homeostasis;GO:0051260|protein homooligomerization;","GO:0031362|anchored component of external side of plasma membrane;","GO:0005507|copper ion binding;",".","."]
["gene16838",13106,3688,3857,5808.91908371575,813,1583,1020,1253.00712525291,4.63598248297531,2.2128751151424,{"v":3.14306119761631e-06,"d":"3.14E-06"},0.000158716246069365,"up","yes","GPCPD1","protein_coding","chrNC_037340.1:47717357-47784462:-","gi|297481642|ref|XP_002692410.1|",3088,0,"PREDICTED: glycerophosphocholine phosphodiesterase GPCPD1 isoform X2 [Bos taurus]","gi|982993210|ref|XM_015466072.1|",3616,0,"PREDICTED: Bos taurus glycerophosphocholine phosphodiesterase 1 (GPCPD1), transcript variant X2, mRNA","Q9NPB8",1171,0,"Glycerophosphocholine phosphodiesterase GPCPD1","YPL110c_3",150,{"v":1e-37,"d":"1.00E-37"},"COG0584","pfam03009","GDPD","Glycerophosphoryl diester phosphodiesterase family. Escherichia coli has two sequence related isozymes of glycerophosphoryl diester phosphodiesterase (GDPD) - periplasmic and cytosolic. This family also includes agrocinopine synthase, the similarity to GDPD has been noted. This family appears to have weak but not significant matches to mammalian phospholipase C pfam00388, which suggests that this family may adopt a TIM barrel fold.","GO:0030643|cellular phosphate ion homeostasis;GO:0046475|glycerophospholipid catabolic process;GO:0007519|skeletal muscle tissue development;","GO:0005829|cytosol;","GO:0047389|glycerophosphocholine phosphodiesterase activity;GO:0008889|glycerophosphodiester phosphodiesterase activity;GO:2001070|starch binding;","K18695","GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [EC:3.1.4.2]"]
["gene16853",474,139,286,256.924958881998,79,67,52,72.8864364464672,3.52500370999344,1.81762477591889,{"v":8.3747351693713e-08,"d":"8.37E-08"},{"v":7.0901949292977e-06,"d":"7.09E-06"},"up","yes","BMP2","protein_coding","chrNC_037340.1:49152163-49163417:+","gi|149642861|ref|NP_001092611.1|",2021,0,"bone morphogenetic protein 2 precursor [Bos taurus]","gi|149642860|ref|NM_001099141.1|",2577,0,"Bos taurus bone morphogenetic protein 2 (BMP2), mRNA","O19006",758,0,"Bone morphogenetic protein 2",".",".",".",".","pfam00688","TGFb_propeptide","TGF-beta propeptide. This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.","GO:0051216|cartilage development;GO:0030154|cell differentiation;GO:0001503|ossification;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0060395|SMAD protein signal transduction;","GO:0005615|extracellular space;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;",".","."]
["gene16873",1136,499,601,644.179220768495,279,251,348,322.013742159661,2.00047121109849,1.0003398669218,0.000232355936943307,0.00566915041247017,"up","yes","HSPA12B","protein_coding","chrNC_037340.1:51444138-51461150:-","gi|528973749|ref|XP_005214758.1|",3423,0,"PREDICTED: heat shock 70 kDa protein 12B isoform X1 [Bos taurus]","gi|982943061|ref|XM_005214701.3|",3026,0,"PREDICTED: Bos taurus heat shock protein family A (Hsp70) member 12B (HSPA12B), transcript variant X1, mRNA","Q96MM6",1254,0,"Heat shock 70 kDa protein 12B",".",".",".",".","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.",".",".","GO:0005524|ATP binding;",".","."]
["gene16888",10,24,26,18.456619143131,0,0,1,0.360972888453242,51.1302087594917,5.67610401130276,{"v":1.6778792751743e-05,"d":"1.68E-05"},0.000655774980821891,"up","yes","OXT","protein_coding","chrNC_037340.1:52113982-52114880:-","gi|594036247|ref|XP_006042791.1|",577,{"v":1e-72,"d":"1.00E-72"},"PREDICTED: oxytocin-neurophysin 1 [Bubalus bubalis]","gi|148744818|gb|BC141997.1|",500,0,"Bos taurus oxytocin, prepropeptide, mRNA (cDNA clone MGC:159461 IMAGE:8389386), complete cds","P01175",210,{"v":3e-68,"d":"3.00E-68"},"Oxytocin-neurophysin 1",".",".",".",".","pfam00184","Hormone_5","Neurohypophysial hormones, C-terminal Domain. N-terminal Domain is in hormone5","GO:0043627|response to estrogen;GO:0043207|response to external biotic stimulus;GO:0032094|response to food;GO:0009612|response to mechanical stimulus;","GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005185|neurohypophyseal hormone activity;","K05243","OXT; oxytocin-neurophysin 1"]
["gene16897",832,1416,1429,1119.76358123024,36,25,26,32.0156355711762,34.9755224674773,5.12827370354568,{"v":1.40015965645393e-65,"d":"1.40E-65"},{"v":3.99479551582871e-61,"d":"3.99E-61"},"up","yes","CPXM1","protein_coding","chrNC_037340.1:52382641-52389209:+","gi|164448628|ref|NP_001015642.2|",3681,0,"probable carboxypeptidase X1 precursor [Bos taurus]","gi|164448627|ref|NM_001015642.2|",2351,0,"Bos taurus carboxypeptidase X (M14 family), member 1 (CPXM1), mRNA","Q96SM3",1234,0,"Probable carboxypeptidase X1",".",".",".",".","pfam00246","Peptidase_M14","Zinc carboxypeptidase.",".","GO:0005615|extracellular space;","GO:0004180|carboxypeptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K08638","CPXM1; carboxypeptidase X1 [EC:3.4.17.-]"]
["gene16898",166,131,143,130.112866896833,34,34,34,37.4587706193374,3.47349538560842,1.796388180773,{"v":1.72622675329123e-05,"d":"1.73E-05"},0.000671909624804258,"up","yes","EBF4","protein_coding","chrNC_037340.1:52422074-52481782:-","gi|982993268|ref|XP_015321563.1|",2730,0,"PREDICTED: transcription factor COE4 isoform X4 [Bos taurus]","gi|982993267|ref|XM_015466077.1|",2784,0,"PREDICTED: Bos taurus early B-cell factor 4 (EBF4), transcript variant X6, mRNA","Q9BQW3",1021,0,"Transcription factor COE4",".",".",".",".","pfam01833","TIG","IPT/TIG domain. This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.","GO:0007275|multicellular organismal development;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0046983|protein dimerization activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09103","EBF, COE; early B-cell factor"]
["gene1691",983,2753,1964,1761.58630107205,446,499,385,488.801927202689,3.60388575215576,1.84955327657574,{"v":5.66174845141375e-13,"d":"5.66E-13"},{"v":1.45527337898456e-10,"d":"1.46E-10"},"up","yes","KLHL23","protein_coding","chrNC_037329.1:26570154-26589955:-","gi|965921391|ref|XP_014948857.1|",3037,0,"PREDICTED: kelch-like protein 23 isoform X2 [Ovis aries]","gi|329664787|ref|NM_001205507.1|",3668,0,"Bos taurus kelch-like 23 (Drosophila) (KLHL23), mRNA","Q8NBE8",1154,0,"Kelch-like protein 23",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0016567|protein ubiquitination;","GO:0031463|Cul3-RING ubiquitin ligase complex;",".","K10460","KLHL23; kelch-like protein 23"]
["gene16912",23,21,112,47.2740286746787,10,11,15,13.1891374875314,3.58431540495882,1.84169759418928,0.00295127417895834,0.0408553147015335,"up","yes","TGM3","protein_coding","chrNC_037340.1:52793534-52836111:-","gi|296481047|tpg|DAA23162.1|",3620,0,"TPA: protein-glutamine gamma-glutamyltransferase E [Bos taurus]","gi|156120344|ref|NM_001101848.1|",2553,0,"Bos taurus transglutaminase 3 (TGM3), mRNA","A6QP57",1397,0,"Protein-glutamine gamma-glutamyltransferase E",".",".",".",".","pfam00868","Transglut_N","Transglutaminase family.","GO:0031424|keratinization;GO:0018149|peptide cross-linking;","GO:0005737|cytoplasm;","GO:0005509|calcium ion binding;GO:0003810|protein-glutamine gamma-glutamyltransferase activity;","K05620","TGM3; transglutaminase 3 [EC:2.3.2.13]"]
["gene16946",829,382,453,480.370916818607,215,120,211,200.563927132117,2.39510127113822,1.26008665816606,0.00090415785360705,0.0167292657076931,"up","yes","ZBTB46","protein_coding","chrNC_037340.1:53978514-54030117:+","gi|300793725|ref|NP_001179093.1|",2826,0,"zinc finger and BTB domain-containing protein 46 [Bos taurus]","gi|982942989|ref|XM_005214616.3|",5690,0,"PREDICTED: Bos taurus zinc finger and BTB domain containing 46 (ZBTB46), transcript variant X2, mRNA","Q8BID6",954,0,"Zinc finger and BTB domain-containing protein 46",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:2001199|negative regulation of dendritic cell differentiation;GO:0030853|negative regulation of granulocyte differentiation;GO:0045650|negative regulation of macrophage differentiation;GO:0045656|negative regulation of monocyte differentiation;GO:2001200|positive regulation of dendritic cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0003676|nucleic acid binding;","K10517","ZBTB46, BTBD4; zinc finger and BTB domain-containing protein 46"]
["gene16995",3713,2110,2127,2312.42609618319,421,654,676,641.383908681324,3.60536967779173,1.85014719427143,{"v":9.19704653498117e-10,"d":"9.20E-10"},{"v":1.22617259200723e-07,"d":"1.23E-07"},"up","yes","LAMA5","protein_coding","chrNC_037340.1:54887634-54939286:+","gi|982993396|ref|XP_015321597.1|",17749,0,"PREDICTED: LOW QUALITY PROTEIN: laminin subunit alpha-5 isoform X2 [Bos taurus]","gi|982993395|ref|XM_015466111.1|",9873,0,"PREDICTED: Bos taurus laminin subunit alpha 5 (LAMA5), transcript variant X2, mRNA","O15230",5643,0,"Laminin subunit alpha-5",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0001525|angiogenesis;GO:0060445|branching involved in salivary gland morphogenesis;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0030154|cell differentiation;GO:0016477|cell migration;GO:0008283|cell proliferation;GO:0008037|cell recognition;GO:0060271|cilium morphogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0007010|cytoskeleton organization;GO:0045446|endothelial cell differentiation;GO:0030198|extracellular matrix organization;GO:0048041|focal adhesion assembly;GO:0001942|hair follicle development;GO:0007229|integrin-mediated signaling pathway;GO:0030324|lung development;GO:0001738|morphogenesis of a polarized epithelium;GO:0016331|morphogenesis of embryonic epithelium;GO:0007517|muscle organ development;GO:0001755|neural crest cell migration;GO:0042475|odontogenesis of dentin-containing tooth;GO:0072659|protein localization to plasma membrane;GO:0030155|regulation of cell adhesion;GO:0030334|regulation of cell migration;GO:0042127|regulation of cell proliferation;GO:0045995|regulation of embryonic development;GO:0034446|substrate adhesion-dependent cell spreading;","GO:0005605|basal lamina;GO:0005604|basement membrane;GO:0070062|extracellular exosome;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043259|laminin-10 complex;GO:0043260|laminin-11 complex;GO:0005610|laminin-5 complex;GO:0005634|nucleus;GO:0043083|synaptic cleft;","GO:0005178|integrin binding;","K06240","LAMA3_5; laminin, alpha 3/5"]
["gene17083",349,61,47,125.383004867021,16,20,21,20.9004714802651,5.99905150395347,2.58473441760224,{"v":2.09706331196282e-08,"d":"2.10E-08"},{"v":2.04901758060312e-06,"d":"2.05E-06"},"up","yes","TCF15","protein_coding","chrNC_037340.1:60451109-60457091:+","gi|126165268|ref|NP_001075190.1|",688,{"v":3e-86,"d":"3.00E-86"},"transcription factor 15 [Bos taurus]","gi|402744123|ref|NM_001081721.2|",1051,0,"Bos taurus transcription factor 15 (basic helix-loop-helix) (TCF15), mRNA","Q60756",254,{"v":5e-82,"d":"5.00E-82"},"Transcription factor 15",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0009952|anterior/posterior pattern specification;GO:0043583|ear development;GO:0042755|eating behavior;GO:0045198|establishment of epithelial cell apical/basal polarity;GO:0060231|mesenchymal to epithelial transition;GO:0007517|muscle organ development;GO:0048644|muscle organ morphogenesis;GO:0050884|neuromuscular process controlling posture;GO:0048339|paraxial mesoderm development;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0036342|post-anal tail morphogenesis;GO:1903053|regulation of extracellular matrix organization;GO:0010468|regulation of gene expression;GO:0003016|respiratory system process;GO:0048705|skeletal system morphogenesis;GO:0043588|skin development;GO:0001756|somitogenesis;GO:0006366|transcription from RNA polymerase II promoter;","GO:0090575|RNA polymerase II transcription factor complex;","GO:0003677|DNA binding;GO:0046983|protein dimerization activity;","K09070","TCF15, PARAXIS; transcription factor 15"]
["gene17170",0,25,1,8.50006361377289,0,0,0,0,"Inf","Inf",0.00159800597169451,0.0261426080151469,"up","yes","C13H20orf144","protein_coding","chrNC_037340.1:63115490-63117089:+","gi|594105757|ref|XP_006075821.1|",533,{"v":5e-65,"d":"5.00E-65"},"PREDICTED: uncharacterized protein C20orf144 homolog [Bubalus bubalis]","gi|982993619|ref|XM_005192468.3|",691,0,"PREDICTED: Bos taurus chromosome 13 open reading frame, human C20orf144 (C13H20orf144), mRNA",".",".",".",".",".",".",".",".","pfam15318","Bclt","Putative Bcl-2 like protein of testis. This family of proteins is found in eukaryotes. The family may represent a set of Bcl-2-like proteins involved in apoptosis, see UniProt:Q9BQM9.",".",".",".",".","."]
["gene17179",412,6,0,109.343079651759,0,1,0,0.366987568989444,297.947638806545,8.21891500411472,{"v":4.88348088137594e-23,"d":"4.88E-23"},{"v":5.35886896255912e-20,"d":"5.36E-20"},"up","yes","ASIP","protein_coding","chrNC_037340.1:63639821-63668127:+","gi|594047425|ref|XP_006048130.1|",439,{"v":6e-51,"d":"6.00E-51"},"PREDICTED: agouti-signaling protein [Bubalus bubalis]","gi|75832094|ref|NM_206843.2|",756,0,"Bos taurus agouti signaling protein (ASIP), mRNA","Q29414",165,{"v":2e-49,"d":"2.00E-49"},"Agouti-signaling protein",".",".",".",".","pfam05039","Agouti","Agouti protein. The agouti protein regulates pigmentation in the mouse hair follicle producing a black hair with a subapical yellow band. A highly homologous protein agouti signal protein (ASIP)is present in humans and is expressed at highest levels in adipose tissue where it may play a role in energy homeostasis and possibly human pigmentation.","GO:0008343|adult feeding behavior;GO:0006091|generation of precursor metabolites and energy;GO:0071514|genetic imprinting;GO:0009755|hormone-mediated signaling pathway;GO:0042438|melanin biosynthetic process;GO:0032438|melanosome organization;GO:0032402|melanosome transport;GO:0048023|positive regulation of melanin biosynthetic process;GO:0040030|regulation of molecular function, epigenetic;","GO:0005576|extracellular region;GO:0005622|intracellular;","GO:0031781|type 3 melanocortin receptor binding;GO:0031782|type 4 melanocortin receptor binding;","K08725","ASIP; agouti signaling protein"]
["gene172",4309,4660,5819,4437.3306985955,1576,1732,1622,1810.17900469225,2.45132149201448,1.29355970677467,{"v":2.37181114264168e-07,"d":"2.37E-07"},{"v":1.75766607040804e-05,"d":"1.76E-05"},"up","yes","NRIP1","protein_coding","chrNC_037328.1:22189539-22196882:+","gi|742144590|ref|XP_010843431.1|",5977,0,"PREDICTED: nuclear receptor-interacting protein 1 [Bison bison bison]","gi|982975212|ref|XM_015461930.1|",7325,0,"PREDICTED: Bos taurus nuclear receptor interacting protein 1 (NRIP1), transcript variant X2, mRNA","P48552",2017,0,"Nuclear receptor-interacting protein 1",".",".",".",".","pfam09726","Macoilin","Transmembrane protein. This entry is a highly conserved protein present in eukaryotes.","GO:0030521|androgen receptor signaling pathway;GO:0071392|cellular response to estradiol stimulus;GO:0032922|circadian regulation of gene expression;GO:0007623|circadian rhythm;GO:0019915|lipid storage;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0001543|ovarian follicle rupture;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0000118|histone deacetylase complex;GO:0000790|nuclear chromatin;GO:0016607|nuclear speck;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0050681|androgen receptor binding;GO:0001046|core promoter sequence-specific DNA binding;GO:0030331|estrogen receptor binding;GO:0035259|glucocorticoid receptor binding;GO:0042826|histone deacetylase binding;GO:0035257|nuclear hormone receptor binding;GO:0046965|retinoid X receptor binding;GO:0003713|transcription coactivator activity;GO:0003714|transcription corepressor activity;","K17965","NRIP1; nuclear receptor-interacting protein 1"]
["gene17213",1417,2103,1905,1643.56011799181,672,800,710,801.052962597599,2.0517496279674,1.03685469170134,{"v":3.8586402977245e-05,"d":"3.86E-05"},0.0013013104767657,"up","yes","ERGIC3","protein_coding","chrNC_037340.1:64776881-64790801:+","gi|564343767|ref|XP_006235376.1|",2044,0,"PREDICTED: endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform X1 [Rattus norvegicus]","gi|942067191|ref|XM_005900028.2|",1371,0,"PREDICTED: Bos mutus ERGIC and golgi 3 (ERGIC3), transcript variant X1, mRNA","Q5EAE0",756,0,"Endoplasmic reticulum-Golgi intermediate compartment protein 3",".",".",".",".","pfam07970","COPIIcoated_ERV","Endoplasmic reticulum vesicle transporter. This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localisation. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.","GO:0016192|vesicle-mediated transport;","GO:0005789|endoplasmic reticulum membrane;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;",".",".","."]
["gene17255",65,164,106,103.241102946694,30,19,35,30.8198576122094,3.34982413759739,1.7440853575179,0.000125413615034847,0.00350801553976394,"up","yes","VSTM2L","protein_coding","chrNC_037340.1:66799413-66838316:+","gi|635020998|ref|XP_008016040.1|",1035,{"v":2e-132,"d":"2.00E-132"},"PREDICTED: V-set and transmembrane domain-containing protein 2-like protein [Chlorocebus sabaeus]","gi|118151053|ref|NM_001077976.1|",1951,0,"Bos taurus V-set and transmembrane domain containing 2 like (VSTM2L), mRNA","Q96N03",382,{"v":1e-127,"d":"1.00E-127"},"V-set and transmembrane domain-containing protein 2-like protein",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0043524|negative regulation of neuron apoptotic process;","GO:0005737|cytoplasm;GO:0005576|extracellular region;",".",".","."]
["gene17259",2458,1837,2390,1976.64999716928,431,458,505,511.465662135738,3.86467781417689,1.95034814629402,{"v":2.39945095299896e-15,"d":"2.40E-15"},{"v":8.89074482337834e-13,"d":"8.89E-13"},"up","yes","TGM2","protein_coding","chrNC_037340.1:67002550-67037025:-","gi|73586866|gb|AAI03291.1|",3604,0,"Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) [Bos taurus]","gi|73586865|gb|BC103290.1|",3862,0,"Bos taurus transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), mRNA (cDNA clone MGC:128824 IMAGE:8119404), complete cds","P51176",1392,0,"Protein-glutamine gamma-glutamyltransferase 2",".",".",".",".","pfam00868","Transglut_N","Transglutaminase family.","GO:0018149|peptide cross-linking;",".","GO:0046872|metal ion binding;GO:0003810|protein-glutamine gamma-glutamyltransferase activity;","K05625","TGM2; transglutaminase 2 [EC:2.3.2.13]"]
["gene17303",202,171,162,158.439321629754,27,38,27,33.7835340448283,4.68983858880827,2.22953827004702,{"v":3.31009532040338e-08,"d":"3.31E-08"},{"v":3.19055167521719e-06,"d":"3.19E-06"},"up","yes","EMILIN3","protein_coding","chrNC_037340.1:69990790-69997198:-","gi|803304986|ref|XP_012010942.1|",3320,0,"PREDICTED: EMILIN-3 [Ovis aries musimon]","gi|942038442|ref|XM_005889780.2|",3201,0,"PREDICTED: Bos mutus elastin microfibril interfacer 3 (EMILIN3), mRNA","Q9NT22",1141,0,"EMILIN-3",".",".",".",".","pfam07546","EMI","EMI domain. The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.",".","GO:0005737|cytoplasm;GO:0031012|extracellular matrix;",".",".","."]
["gene17325",7839,19262,15165,13013.0230641033,3510,3335,3805,3909.33137969332,3.32870810893604,1.73496236754839,{"v":5.65146449842068e-10,"d":"5.65E-10"},{"v":8.10260972886636e-08,"d":"8.10E-08"},"up","yes","JPH2","protein_coding","chrNC_037340.1:72584144-72659231:-","gi|803276278|ref|XP_011997820.1|",2192,0,"PREDICTED: junctophilin-2 isoform X2 [Ovis aries musimon]","gi|982993813|ref|XM_015466184.1|",4319,0,"PREDICTED: Bos taurus junctophilin 2 (JPH2), transcript variant X2, mRNA","Q9BR39",768,0,"Junctophilin-2",".",".",".",".","pfam02493","MORN","MORN repeat. The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22).  #=GF CC   A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesised to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.","GO:0055074|calcium ion homeostasis;GO:0060402|calcium ion transport into cytosol;GO:0060316|positive regulation of ryanodine-sensitive calcium-release channel activity;GO:0055024|regulation of cardiac muscle tissue development;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;","GO:0016021|integral component of membrane;GO:0030314|junctional membrane complex;GO:0014701|junctional sarcoplasmic reticulum membrane;GO:0005886|plasma membrane;GO:0030018|Z disc;","GO:0015278|calcium-release channel activity;GO:0070300|phosphatidic acid binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0080025|phosphatidylinositol-3,5-bisphosphate binding;GO:0032266|phosphatidylinositol-3-phosphate binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0070273|phosphatidylinositol-4-phosphate binding;GO:0010314|phosphatidylinositol-5-phosphate binding;GO:0001786|phosphatidylserine binding;","K19530","JPH; junctophilin"]
["gene17341",140,247,142,161.044791893448,51,17,51,43.710578583365,3.68434363288746,1.88140762558306,0.00237231801278261,0.0348412513478246,"up","yes","WISP2","protein_coding","chrNC_037340.1:73110493-73125825:+","gi|528973905|ref|XP_005214836.1|",1039,{"v":2e-132,"d":"2.00E-132"},"PREDICTED: WNT1-inducible-signaling pathway protein 2 isoform X1 [Bos taurus]","gi|982943145|ref|XM_005214779.3|",2392,0,"PREDICTED: Bos taurus WNT1 inducible signaling pathway protein 2 (WISP2), transcript variant X1, mRNA","O76076",338,{"v":2e-108,"d":"2.00E-108"},"WNT1-inducible-signaling pathway protein 2",".",".",".",".","pfam00093","VWC","von Willebrand factor type C domain. The high cutoff was used to prevent overlap with pfam00094.","GO:0007155|cell adhesion;GO:0007267|cell-cell signaling;GO:0060548|negative regulation of cell death;GO:0001558|regulation of cell growth;GO:0007165|signal transduction;","GO:0005615|extracellular space;","GO:0008201|heparin binding;GO:0005520|insulin-like growth factor binding;GO:0005178|integrin binding;",".","."]
["gene1740",1657,334,651,741.246591771478,295,277,276,311.545660427712,2.37925506891619,1.25050994470743,{"v":8.49388681627648e-06,"d":"8.49E-06"},0.000377475209899041,"up","yes","COBLL1","protein_coding","chrNC_037329.1:31429854-31597850:+","gi|741916609|ref|XP_010800344.1|",4677,0,"PREDICTED: cordon-bleu protein-like 1 [Bos taurus]","gi|982977309|ref|XM_015462276.1|",3051,0,"PREDICTED: Bos taurus cordon-bleu WH2 repeat protein like 1 (COBLL1), mRNA","Q53SF7",1261,0,"Cordon-bleu protein-like 1",".",".",".",".","pfam09469","Cobl","Cordon-bleu ubiquitin-like domain. The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.","GO:0051639|actin filament network formation;GO:0030041|actin filament polymerization;","GO:0070062|extracellular exosome;","GO:0003785|actin monomer binding;GO:0045296|cadherin binding;",".","."]
["gene17475",533,1352,943,871.602188013453,311,334,391,379.956123475191,2.29395483889434,1.19783698928551,{"v":1.36694421483554e-05,"d":"1.37E-05"},0.000557146934192468,"up","yes","SPATA2","protein_coding","chrNC_037340.1:77982558-77993174:-","gi|300793805|ref|NP_001179609.1|",2341,0,"spermatogenesis-associated protein 2 [Bos taurus]","gi|982943116|ref|XM_010811488.2|",4958,0,"PREDICTED: Bos taurus spermatogenesis associated 2 (SPATA2), transcript variant X2, mRNA","Q9UM82",738,0,"Spermatogenesis-associated protein 2",".",".",".",".","pfam13771","zf-HC5HC2H","PHD-like zinc-binding domain. The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.","GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0001650|fibrillar center;GO:0005634|nucleus;",".","K17595","SPATA2; spermatogenesis-associated protein 2"]
["gene17507",615,1005,1137,838.836855669306,282,391,366,381.010818080896,2.20160902489441,1.13855828909874,{"v":2.3217228259126e-05,"d":"2.32E-05"},0.000858982012377291,"up","yes","NFATC2","protein_coding","chrNC_037340.1:79241655-79402102:-","gi|528914212|ref|XP_005192574.1|",4166,0,"PREDICTED: nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [Bos taurus]","gi|982993975|ref|XM_005192517.3|",7168,0,"PREDICTED: Bos taurus nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (NFATC2), transcript variant X1, mRNA","Q13469",1469,0,"Nuclear factor of activated T-cells, cytoplasmic 2",".",".",".",".","pfam00554","RHD","Rel homology domain (RHD). Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam01833) that binds to DNA.","GO:0050853|B cell receptor signaling pathway;GO:0033173|calcineurin-NFAT signaling cascade;GO:0016477|cell migration;GO:0006974|cellular response to DNA damage stimulus;GO:0001816|cytokine production;GO:0038095|Fc-epsilon receptor signaling pathway;GO:0014904|myotube cell development;GO:0030890|positive regulation of B cell proliferation;GO:1901741|positive regulation of myoblast fusion;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045589|regulation of regulatory T cell differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0042493|response to drug;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0000790|nuclear chromatin;GO:0044798|nuclear transcription factor complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019902|phosphatase binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K17332","NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2"]
["gene17564",1001,885,927,835.615760525592,198,346,259,294.475758836344,2.83763853373747,1.50469082660877,{"v":2.31105717877982e-05,"d":"2.31E-05"},0.000856321719061912,"up","yes","GPT","protein_coding","chrNC_037341.1:438334-441339:-","gi|982944185|ref|XP_015329844.1|",2646,0,"PREDICTED: alanine aminotransferase 1 isoform X3 [Bos taurus]","gi|402766788|ref|NM_001083740.2|",1835,0,"Bos taurus glutamic-pyruvate transaminase (alanine aminotransferase) (GPT), mRNA","A4IFH5",951,0,"Alanine aminotransferase 1","YDR111c",374,{"v":4e-121,"d":"4.00E-121"},"COG0436","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0009058|biosynthetic process;GO:0042853|L-alanine catabolic process;","GO:0005737|cytoplasm;GO:0005615|extracellular space;","GO:0004021|L-alanine:2-oxoglutarate aminotransferase activity;GO:0030170|pyridoxal phosphate binding;","K00814","GPT, ALT; alanine transaminase [EC:2.6.1.2]"]
["gene17606",393,235,171,231.956386037166,30,57,61,54.1506803335926,4.28353595205471,2.098802197191,{"v":6.72098045905737e-07,"d":"6.72E-07"},{"v":4.31883543867941e-05,"d":"4.32E-05"},"up","yes","EPPK1","protein_coding","chrNC_037341.1:936290-955875:+","gi|528975308|ref|XP_003586920.2|",19986,0,"PREDICTED: LOW QUALITY PROTEIN: epiplakin [Bos taurus]","gi|982994114|ref|XM_003583018.4|",13449,0,"PREDICTED: Bos taurus epiplakin 1 (EPPK1), mRNA","Q8R0W0",6445,0,"Epiplakin",".",".",".",".","pfam00681","Plectin","Plectin repeat. This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.","GO:0007010|cytoskeleton organization;GO:0045110|intermediate filament bundle assembly;GO:0045109|intermediate filament organization;GO:0030336|negative regulation of cell migration;GO:0050680|negative regulation of epithelial cell proliferation;GO:0051548|negative regulation of keratinocyte migration;GO:0010839|negative regulation of keratinocyte proliferation;GO:0061045|negative regulation of wound healing;GO:0060054|positive regulation of epithelial cell proliferation involved in wound healing;GO:0030856|regulation of epithelial cell differentiation;GO:0042060|wound healing;","GO:0016327|apicolateral plasma membrane;GO:0045178|basal part of cell;GO:0016323|basolateral plasma membrane;GO:0005923|bicellular tight junction;GO:0071944|cell periphery;GO:0042995|cell projection;GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0030056|hemidesmosome;GO:0045111|intermediate filament cytoskeleton;GO:0045095|keratin filament;GO:0097356|perinucleolar compartment;","GO:0008092|cytoskeletal protein binding;GO:0019215|intermediate filament binding;GO:1990254|keratin filament binding;",".","."]
["gene17625",105,635,346,341.730251392391,76,129,102,112.56700587592,3.03579409200127,1.6020739407788,{"v":6.51002668616985e-06,"d":"6.51E-06"},0.000296232171264931,"up","yes","MAFA","protein_coding","chrNC_037341.1:1223093-1226198:+","gi|148697540|gb|EDL29487.1|",503,{"v":2e-55,"d":"2.00E-55"},"v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian), partial [Mus musculus]","gi|982994161|ref|XM_015466272.1|",3061,0,"PREDICTED: Bos taurus v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A (MAFA), mRNA","Q8CF90",199,{"v":1e-54,"d":"1.00E-54"},"Transcription factor MafA",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.","GO:0030073|insulin secretion;GO:0007263|nitric oxide mediated signal transduction;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0009749|response to glucose;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K07595","MAFA; transcription factor MAFA"]
["gene17646",5241,5697,6039,5087.64154805786,1665,1443,1717,1771.67738168382,2.87165236778183,1.52188111210227,{"v":1.18471188082487e-09,"d":"1.18E-09"},{"v":1.55050526017497e-07,"d":"1.55E-07"},"up","yes","LYNX1","protein_coding","chrNC_037341.1:1669740-1675364:+","gi|585189675|ref|XP_006746162.1|",327,{"v":2e-31,"d":"2.00E-31"},"PREDICTED: ly-6/neurotoxin-like protein 1-like isoform X1 [Leptonychotes weddellii]","gi|982944115|ref|XM_005215196.3|",4314,0,"PREDICTED: Bos taurus Ly6/neurotoxin 1 (LYNX1), transcript variant X1, mRNA","P0DP62",129,{"v":2e-32,"d":"2.00E-32"},"Ly-6/neurotoxin-like protein 1",".",".",".",".","pfam00021","UPAR_LY6","u-PAR/Ly-6 domain. This extracellular disulphide bond rich domain is related to pfam00087.",".","GO:0031225|anchored component of membrane;GO:0030425|dendrite;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;","GO:0033130|acetylcholine receptor binding;GO:0030548|acetylcholine receptor regulator activity;",".","."]
["gene17652",17,97,629,229.398717448751,17,15,13,16.5515186178768,13.8596779392184,3.79282182848869,{"v":4.0618888684088e-20,"d":"4.06E-20"},{"v":2.63385798419481e-17,"d":"2.63E-17"},"up","yes","ARC","protein_coding","chrNC_037341.1:1741147-1744556:+","gi|329755360|ref|NP_001193336.1|",2004,0,"activity-regulated cytoskeleton-associated protein [Bos taurus]","gi|982944120|ref|XM_005215201.3|",2909,0,"PREDICTED: Bos taurus activity-regulated cytoskeleton-associated protein (ARC), transcript variant X1, mRNA","Q7LC44",709,0,"Activity-regulated cytoskeleton-associated protein",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0009952|anterior/posterior pattern specification;GO:0016477|cell migration;GO:0007010|cytoskeleton organization;GO:0060997|dendritic spine morphogenesis;GO:0006897|endocytosis;GO:0007492|endoderm development;GO:0007612|learning;GO:0007616|long-term memory;GO:0060291|long-term synaptic potentiation;GO:0051028|mRNA transport;GO:2000969|positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;GO:0051260|protein homooligomerization;GO:0022604|regulation of cell morphogenesis;GO:0061001|regulation of dendritic spine morphogenesis;GO:1900452|regulation of long term synaptic depression;GO:1900271|regulation of long-term synaptic potentiation;GO:0048168|regulation of neuronal synaptic plasticity;","GO:0001669|acrosomal vesicle;GO:0015629|actin cytoskeleton;GO:0005938|cell cortex;GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0043197|dendritic spine;GO:0031901|early endosome membrane;GO:1903561|extracellular vesicle;GO:0045121|membrane raft;GO:0043025|neuronal cell body;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;","GO:0003729|mRNA binding;","K15867","ARC; activity-regulated cytoskeleton-associated protein"]
["gene17665",5953,9798,6487,6754.76598696791,2252,3047,2781,2963.80246459566,2.27908778255552,1.18845649328182,{"v":6.29071383172897e-06,"d":"6.29E-06"},0.000287168570132895,"up","yes","PTP4A3","protein_coding","chrNC_037341.1:2553478-2585771:-","gi|139949068|ref|NP_001077235.1|",883,{"v":4e-110,"d":"4.00E-110"},"protein tyrosine phosphatase type IVA 3 [Bos taurus]","gi|982944007|ref|XM_010811816.2|",2464,0,"PREDICTED: Bos taurus protein tyrosine phosphatase type IVA, member 3 (PTP4A3), transcript variant X1, mRNA","A2VDT1",344,{"v":1e-111,"d":"1.00E-111"},"Protein tyrosine phosphatase type IVA 3","DR2161",64.7,{"v":7e-11,"d":"7.00E-11"},"COG2453","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:1990830|cellular response to leukemia inhibitory factor;GO:0043542|endothelial cell migration;GO:0007219|Notch signaling pathway;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:0043117|positive regulation of vascular permeability;GO:0006355|regulation of transcription, DNA-templated;GO:1900746|regulation of vascular endothelial growth factor signaling pathway;","GO:0005737|cytoplasm;GO:0005769|early endosome;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;","K18041","PTP4A; protein tyrosine phosphatase type IVA [EC:3.1.3.48]"]
["gene17685",0,33,0,10.8146834138175,0,0,0,0,"Inf","Inf",0.00037638262285238,0.00840921896053349,"up","yes","FAM135B","protein_coding","chrNC_037341.1:4387975-4651873:+","gi|528975232|ref|XP_005215298.1|",7127,0,"PREDICTED: protein FAM135B isoform X1 [Bos taurus]","gi|594058628|ref|XM_006053410.1|",7275,0,"PREDICTED: Bubalus bubalis family with sequence similarity 135, member B (FAM135B), transcript variant X1, mRNA","Q49AJ0",2160,0,"Protein FAM135B",".",".",".",".","pfam05057","DUF676","Putative serine esterase (DUF676). This family of proteins are probably serine esterase type enzymes with an alpha/beta hydrolase fold.","GO:0044255|cellular lipid metabolic process;",".","GO:0052689|carboxylic ester hydrolase activity;",".","."]
["gene17774",4626,3413,2730,3162.58559248653,862,1543,1085,1280.10549666185,2.47056637186048,1.30484181436374,0.000385108162044045,0.00857060918196463,"up","yes","KLHL38","protein_coding","chrNC_037341.1:16228954-16241276:+","gi|528914574|ref|XP_594631.4|",3218,0,"PREDICTED: kelch-like protein 38 [Bos taurus]","gi|982994355|ref|XM_594631.8|",3000,0,"PREDICTED: Bos taurus kelch like family member 38 (KLHL38), mRNA","Q2WGJ6",1025,0,"Kelch-like protein 38",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0016567|protein ubiquitination;","GO:0031463|Cul3-RING ubiquitin ligase complex;",".","K13959","KLHL38; kelch-like protein 38"]
["gene17880",3360,3676,2881,2965.20169095804,1174,1125,1148,1266.0616289345,2.34206741851383,1.22778260570916,{"v":6.98721933569954e-07,"d":"6.99E-07"},{"v":4.46043659746056e-05,"d":"4.46E-05"},"up","yes","CHD7","protein_coding","chrNC_037341.1:26298023-26488716:+","gi|594046779|ref|XP_006047824.1|",12472,0,"PREDICTED: chromodomain-helicase-DNA-binding protein 7 isoform X1 [Bubalus bubalis]","gi|742114387|ref|XM_010839000.1|",10120,0,"PREDICTED: Bison bison bison chromodomain helicase DNA binding protein 7 (CHD7), mRNA","Q9P2D1",2607,0,"Chromodomain-helicase-DNA-binding protein 7","ECU01g0350",633,0,"COG0553","pfam00176","SNF2_N","SNF2 family N-terminal domain. This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1).","GO:0007512|adult heart development;GO:0007628|adult walking behavior;GO:0035909|aorta morphogenesis;GO:0036302|atrioventricular canal development;GO:0008015|blood circulation;GO:0001974|blood vessel remodeling;GO:0060411|cardiac septum morphogenesis;GO:0007417|central nervous system development;GO:0006338|chromatin remodeling;GO:0050890|cognition;GO:0021545|cranial nerve development;GO:0035116|embryonic hindlimb morphogenesis;GO:0060429|epithelium development;GO:0060324|face development;GO:0030540|female genitalia development;GO:0048806|genitalia development;GO:0003007|heart morphogenesis;GO:0001701|in utero embryonic development;GO:0042472|inner ear morphogenesis;GO:0060384|innervation;GO:0060173|limb development;GO:0043584|nose development;GO:0042048|olfactory behavior;GO:0021772|olfactory bulb development;GO:0021553|olfactory nerve development;GO:0040018|positive regulation of multicellular organism growth;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0060123|regulation of growth hormone secretion;GO:0050767|regulation of neurogenesis;GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;GO:0006355|regulation of transcription, DNA-templated;GO:0060041|retina development in camera-type eye;GO:0003226|right ventricular compact myocardium morphogenesis;GO:0006364|rRNA processing;GO:0048752|semicircular canal morphogenesis;GO:0007605|sensory perception of sound;GO:0001501|skeletal system development;GO:0030217|T cell differentiation;GO:0006351|transcription, DNA-templated;GO:0003222|ventricular trabecula myocardium morphogenesis;","GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003682|chromatin binding;GO:0004386|helicase activity;GO:1990841|promoter-specific chromatin binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;","K14437","CHD7; chromodomain-helicase-DNA-binding protein 7 [EC:3.6.4.12]"]
["gene17953",665,1331,1000,916.628317128156,200,367,280,310.51046462301,2.95200459102411,1.56169496511191,{"v":6.57548216883232e-05,"d":"6.58E-05"},0.00204809041221566,"up","yes","EYA1","protein_coding","chrNC_037341.1:34786252-35159938:-","gi|742154069|ref|XP_010845262.1|",2669,0,"PREDICTED: eyes absent homolog 1 isoform X1 [Bison bison bison]","gi|742154088|ref|XM_010846965.1|",3918,0,"PREDICTED: Bison bison bison EYA transcriptional coactivator and phosphatase 1 (EYA1), transcript variant X6, mRNA","Q99502",1009,0,"Eyes absent homolog 1",".",".",".",".","pfam07223","DUF1421","Protein of unknown function (DUF1421). This family represents a conserved region approximately 350 residues long within a number of plant proteins of unknown function.","GO:0009653|anatomical structure morphogenesis;GO:0035909|aorta morphogenesis;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0030154|cell differentiation;GO:0090103|cochlea morphogenesis;GO:0006302|double-strand break repair;GO:0048704|embryonic skeletal system morphogenesis;GO:0016576|histone dephosphorylation;GO:0007501|mesodermal cell fate specification;GO:0001656|metanephros development;GO:0042474|middle ear morphogenesis;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0048665|neuron fate specification;GO:0071600|otic vesicle morphogenesis;GO:0042473|outer ear morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0007389|pattern specification process;GO:0060037|pharyngeal system development;GO:0045739|positive regulation of DNA repair;GO:0050679|positive regulation of epithelial cell proliferation;GO:0072513|positive regulation of secondary heart field cardioblast proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0016925|protein sumoylation;GO:0045664|regulation of neuron differentiation;GO:0010212|response to ionizing radiation;GO:0048752|semicircular canal morphogenesis;GO:0007605|sensory perception of sound;GO:0014706|striated muscle tissue development;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032993|protein-DNA complex;","GO:0046872|metal ion binding;GO:0004725|protein tyrosine phosphatase activity;GO:0003723|RNA binding;","K15616","EYA1; eyes absent homolog 1 [EC:3.1.3.48]"]
["gene1798",29,26,20,22.2211661997835,2,5,4,4.02636557912996,5.51891420763267,2.46438445878836,0.00344926063168311,0.0458151094425284,"up","yes","GALNT5","protein_coding","chrNC_037329.1:39025155-39069651:-","gi|741916401|ref|XP_010800268.1|",4840,0,"PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X1 [Bos taurus]","gi|982913432|ref|XM_010801966.2|",5742,0,"PREDICTED: Bos taurus polypeptide N-acetylgalactosaminyltransferase 5 (GALNT5), transcript variant X1, mRNA","Q7Z7M9",1452,0,"Polypeptide N-acetylgalactosaminyltransferase 5",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0006024|glycosaminoglycan biosynthetic process;GO:0016266|O-glycan processing;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["gene1804",2143,3948,3631,2967.50364567864,1000,1417,1035,1267.39641499203,2.3414171056317,1.22738196248241,{"v":1.29475963392382e-05,"d":"1.29E-05"},0.000533056091132476,"up","yes","GPD2","protein_coding","chrNC_037329.1:39647467-39802943:-","gi|154152051|ref|NP_001093766.1|",3661,0,"glycerol-3-phosphate dehydrogenase, mitochondrial precursor [Bos taurus]","gi|982913434|ref|XM_005202414.3|",5808,0,"PREDICTED: Bos taurus glycerol-3-phosphate dehydrogenase 2 (GPD2), transcript variant X1, mRNA","A6QLU1",1414,0,"Glycerol-3-phosphate dehydrogenase, mitochondrial","SPCC1223.03c",442,{"v":1e-133,"d":"1.00E-133"},"COG0578","pfam01266","DAO","FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.","GO:0043010|camera-type eye development;GO:0006094|gluconeogenesis;GO:0019563|glycerol catabolic process;GO:0006072|glycerol-3-phosphate metabolic process;GO:0035264|multicellular organism growth;","GO:0009331|glycerol-3-phosphate dehydrogenase complex;GO:0005739|mitochondrion;","GO:0005509|calcium ion binding;GO:0052591|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity;","K00111","glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]"]
["gene18053",2,28,9,12.4614361939299,0,0,1,0.360972888453242,34.5218064639889,5.10943605501399,0.00058728969376344,0.0119726941326202,"up","yes","AARD","protein_coding","chrNC_037341.1:47338509-47344661:-","gi|76674486|ref|XP_873245.1|",561,{"v":7e-65,"d":"7.00E-65"},"PREDICTED: alanine and arginine-rich domain-containing protein [Bos taurus]","gi|982994610|ref|XM_868152.8|",1907,0,"PREDICTED: Bos taurus alanine and arginine rich domain containing protein (AARD), mRNA","Q4LEZ3",101,{"v":3e-23,"d":"3.00E-23"},"Alanine and arginine-rich domain-containing protein",".",".",".",".","pfam09804","DUF2347","Uncharacterized conserved protein (DUF2347). Members of this family of hypothetical proteins have no known function.","GO:0030324|lung development;",".",".",".","."]
["gene18097",368,110,233,203.517636499139,13,46,31,32.9305728879684,6.18020333844531,2.62765430585468,{"v":6.23230731238644e-05,"d":"6.23E-05"},0.00196696858329311,"up","yes","ANGPT1","protein_coding","chrNC_037341.1:56984054-57285254:+","gi|50510321|dbj|BAD32146.1|",2569,0,"mKIAA0003 protein [Mus musculus]","gi|116003814|ref|NM_001076797.1|",2185,0,"Bos taurus angiopoietin 1 (ANGPT1), mRNA","O18920",979,0,"Angiopoietin-1",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0001525|angiogenesis;GO:0030154|cell differentiation;GO:0048014|Tie signaling pathway;","GO:0005576|extracellular region;","GO:0030971|receptor tyrosine kinase binding;","K05465","ANGPT1; angiopoietin 1"]
["gene18127",2349,14787,11101,8867.52256043967,975,1850,1253,1495.64991979265,5.92887576370078,2.56775856617102,{"v":1.81289892390492e-08,"d":"1.81E-08"},{"v":1.82126123936377e-06,"d":"1.82E-06"},"up","yes","KLF10","protein_coding","chrNC_037341.1:61770393-61776503:+","gi|270297153|ref|NP_001161934.1|",2221,0,"Krueppel-like factor 10 [Bos taurus]","gi|270297152|ref|NM_001168462.1|",2901,0,"Bos taurus Kruppel-like factor 10 (KLF10), mRNA","Q13118",769,0,"Krueppel-like factor 10","SPAC4G8.13c",83.2,{"v":2e-15,"d":"2.00E-15"},"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0030282|bone mineralization;GO:0008283|cell proliferation;GO:0007267|cell-cell signaling;GO:1901653|cellular response to peptide;GO:0009267|cellular response to starvation;GO:0007623|circadian rhythm;GO:0008285|negative regulation of cell proliferation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045672|positive regulation of osteoclast differentiation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0042752|regulation of circadian rhythm;GO:0001501|skeletal system development;GO:0035019|somatic stem cell population maintenance;GO:0007179|transforming growth factor beta receptor signaling pathway;","GO:0005634|nucleus;","GO:0001046|core promoter sequence-specific DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09209","KLF10_11, TIEG; krueppel-like factor 10/11"]
["gene18128",0,65,0,21.3016491484285,0,0,0,0,"Inf","Inf",{"v":7.29569159369161e-07,"d":"7.30E-07"},{"v":4.62563059688034e-05,"d":"4.63E-05"},"up","yes","ODF1","protein_coding","chrNC_037341.1:61844560-61854021:-","gi|594043987|ref|XP_006046499.1|",997,{"v":5e-132,"d":"5.00E-132"},"PREDICTED: outer dense fiber protein 1 [Bubalus bubalis]","gi|75832060|ref|NM_174131.3|",1057,0,"Bos taurus outer dense fiber of sperm tails 1 (ODF1), mRNA","Q29438",388,{"v":2e-133,"d":"2.00E-133"},"Outer dense fiber protein 1",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.","GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0007283|spermatogenesis;","GO:0001520|outer dense fiber;",".",".","."]
["gene18170",131,376,272,240.900575748626,33,48,35,42.583801383458,5.65709419831658,2.50006119401734,{"v":1.07071845272211e-11,"d":"1.07E-11"},{"v":2.12143528990379e-09,"d":"2.12E-09"},"up","yes","OSR2","protein_coding","chrNC_037341.1:65332262-65339913:-","gi|511898806|ref|XP_004768961.1|",1476,0,"PREDICTED: protein odd-skipped-related 2 isoform X3 [Mustela putorius furo]","gi|402744196|ref|NM_001034328.2|",1753,0,"Bos taurus odd-skipped related transciption factor 2 (OSR2), mRNA","Q3T135",547,0,"Protein odd-skipped-related 2",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0060349|bone morphogenesis;GO:0002062|chondrocyte differentiation;GO:0009792|embryo development ending in birth or egg hatching;GO:0042733|embryonic digit morphogenesis;GO:0035115|embryonic forelimb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0036023|embryonic skeletal limb joint morphogenesis;GO:0048704|embryonic skeletal system morphogenesis;GO:0061029|eyelid development in camera-type eye;GO:0060322|head development;GO:0001823|mesonephros development;GO:0001656|metanephros development;GO:0042474|middle ear morphogenesis;GO:0042476|odontogenesis;GO:0033687|osteoblast proliferation;GO:0030501|positive regulation of bone mineralization;GO:0008284|positive regulation of cell proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0010628|positive regulation of gene expression;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060021|palate development;","GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09215","OSR, ODD; odd-skipped"]
["gene18195",1542,2441,2962,2111.53416489193,1025,814,944,1022.59858029677,2.06487101153527,1.04605166211414,{"v":3.78309095689749e-05,"d":"3.78E-05"},0.00128189273267509,"up","yes","SDC2","protein_coding","chrNC_037341.1:67586062-67707885:-","gi|982945146|ref|XP_015330026.1|",713,{"v":2e-83,"d":"2.00E-83"},"PREDICTED: syndecan-2 isoform X1 [Bos taurus]","gi|982945145|ref|XM_015474540.1|",2804,0,"PREDICTED: Bos taurus syndecan 2 (SDC2), transcript variant X1, mRNA","Q58DD4",278,{"v":6e-85,"d":"6.00E-85"},"Syndecan-2",".",".",".",".","pfam01034","Syndecan","Syndecan domain. Syndecans are transmembrane heparin sulfate proteoglycans which are implicated in the binding of extracellular matrix components and growth factors.","GO:0016477|cell migration;GO:0048813|dendrite morphogenesis;GO:0048814|regulation of dendrite morphogenesis;","GO:0009986|cell surface;GO:0016021|integral component of membrane;","GO:0042802|identical protein binding;GO:0030165|PDZ domain binding;","K16336","SDC2; syndecan 2"]
["gene18198",11400,3647,4921,5677.63683498472,2389,2809,2399,2789.77400814236,2.03516013068216,1.02514231323956,0.000101417963394846,0.00292870031742749,"up","yes","UQCRB","protein_coding","chrNC_037341.1:67986590-67991358:+","gi|77736572|ref|NP_001029969.1|",488,{"v":5e-59,"d":"5.00E-59"},"cytochrome b-c1 complex subunit 7 [Bos taurus]","gi|982945147|ref|XM_005215677.3|",678,0,"PREDICTED: Bos taurus ubiquinol-cytochrome c reductase binding protein (UQCRB), transcript variant X1, mRNA","P00129",192,{"v":2e-60,"d":"2.00E-60"},"Cytochrome b-c1 complex subunit 7",".",".",".",".","pfam02271","UCR_14kD","Ubiquinol-cytochrome C reductase complex 14kD subunit. The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is a respiratory multienzyme complex. This Pfam family represents the 14kD (or VI) subunit of the complex which is not directly involved in electron transfer, but has a role in assembly of the complex.","GO:0009060|aerobic respiration;GO:0006122|mitochondrial electron transport, ubiquinol to cytochrome c;GO:0034551|mitochondrial respiratory chain complex III assembly;","GO:0005750|mitochondrial respiratory chain complex III;",".","K00417","QCR7, UQCRB; ubiquinol-cytochrome c reductase subunit 7"]
["gene18224",3826,4367,3455,3489.39285334652,1331,1628,1355,1584.05935420504,2.2028169866764,1.13934963876001,{"v":4.84929952206421e-06,"d":"4.85E-06"},0.000229445049194053,"up","yes","PDP1","protein_coding","chrNC_037341.1:70358930-70367467:-","gi|414797|gb|AAA30697.1|",2997,0,"pyruvate dehydrogenase phosphatase [Bos taurus]","gi|982945094|ref|XM_010812195.2|",4417,0,"PREDICTED: Bos taurus pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), transcript variant X6, mRNA","P35816",1131,0,"[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial","SPAC10F6.17c",167,{"v":1e-43,"d":"1.00E-43"},"COG0631","pfam00481","PP2C","Protein phosphatase 2C. Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.","GO:0016311|dephosphorylation;","GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0004741|[pyruvate dehydrogenase (lipoamide)] phosphatase activity;GO:0005509|calcium ion binding;GO:0000287|magnesium ion binding;GO:0004722|protein serine/threonine phosphatase activity;","K01102","PDP; pyruvate dehydrogenase phosphatase [EC:3.1.3.43]"]
["gene18266",44,85,59,57.4436015362316,0,0,0,0,"Inf","Inf",{"v":2.90317573118404e-15,"d":"2.90E-15"},{"v":1.06192957418477e-12,"d":"1.06E-12"},"up","yes","LOC112441513","pseudogene","chrNC_037341.1:76473876-76476882:+","gi|982945226|ref|XP_015330041.1|",982,{"v":1e-121,"d":"1.00E-121"},"PREDICTED: LOW QUALITY PROTEIN: solute carrier family 7 member 13 [Bos taurus]","gi|850485665|gb|CP011894.1|",2224,0,"Ovis canadensis canadensis isolate 43U chromosome 9 sequence","Q8TCU3",199,{"v":2e-53,"d":"2.00E-53"},"Solute carrier family 7 member 13",".",".",".",".","pfam13520","AA_permease_2","Amino acid permease.",".","GO:0005887|integral component of plasma membrane;","GO:0015297|antiporter activity;GO:0015179|L-amino acid transmembrane transporter activity;","K13870","SLC7A13, AGT1; solute carrier family 7 (L-type amino acid transporter), member 13"]
["gene18268",137,287,242,204.083792712013,0,3,0,1.10096270696833,185.368488342342,7.53425220409341,0.0003264921487301,0.00749408487161583,"up","yes","LOC101903692","misc_RNA","chrNC_037341.1:76487564-76495653:+",".",".",".",".","gi|982994787|ref|XM_015466408.1|",2575,0,"PREDICTED: Bos taurus solute carrier family 7 (anionic amino acid transporter), member 13 (SLC7A13), mRNA",".",".",".",".",".",".",".",".","pfam14296","O-ag_pol_Wzy","O-antigen polysaccharide polymerase Wzy. This family includes O-antigen polysaccharide polymerases. These enzymes link O-units via a glycosidic linkage to form a long O-antigen. These enzymes vary in specificity and sequence.",".",".",".",".","."]
["gene18311",2214,1577,2769,1944.250429925,606,553,674,672.743315120687,2.89003307238543,1.53108600244686,{"v":5.36777364110054e-10,"d":"5.37E-10"},{"v":7.7347449370828e-08,"d":"7.73E-08"},"up","yes","DEPTOR","protein_coding","chrNC_037341.1:81286798-81449393:+","gi|555993961|ref|XP_005908735.1|",1809,0,"PREDICTED: DEP domain-containing mTOR-interacting protein [Bos mutus]","gi|555993960|ref|XM_005908673.1|",1078,0,"PREDICTED: Bos mutus DEP domain containing MTOR-interacting protein (DEPTOR), mRNA","Q8TB45",665,0,"DEP domain-containing mTOR-interacting protein",".",".",".",".","pfam00610","DEP","Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP). The DEP domain is responsible for mediating intracellular protein targeting and regulation of protein stability in the cell. The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.","GO:0035556|intracellular signal transduction;GO:0045792|negative regulation of cell size;GO:0006469|negative regulation of protein kinase activity;GO:0032007|negative regulation of TOR signaling;GO:2001236|regulation of extrinsic apoptotic signaling pathway;","GO:0005737|cytoplasm;GO:0005622|intracellular;",".",".","."]
["gene18316",2011,4507,3644,3120.28814232965,559,1304,893,1009.83694176433,3.08989304439393,1.62755690059145,0.00184721220936654,0.029037361733023,"up","yes","SNTB1","protein_coding","chrNC_037341.1:81870562-82009881:-","gi|296480435|tpg|DAA22550.1|",1876,0,"TPA: basic beta 1 syntrophin-like [Bos taurus]","gi|982994830|ref|XM_010822727.2|",3765,0,"PREDICTED: Bos taurus syntrophin beta 1 (SNTB1), mRNA","Q13884",665,0,"Beta-1-syntrophin",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0006936|muscle contraction;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0016010|dystrophin-associated glycoprotein complex;GO:0005925|focal adhesion;GO:0032991|macromolecular complex;GO:0042383|sarcolemma;GO:0045202|synapse;","GO:0003779|actin binding;GO:0005516|calmodulin binding;GO:0030165|PDZ domain binding;GO:0005198|structural molecule activity;",".","."]
["gene18411",118,72,38,66.0198369266554,11,19,18,17.5817247949915,3.75502618181479,1.90882296692534,0.00032449829557872,0.00746485789649632,"up","yes","TRPC6","protein_coding","chrNC_037342.1:7313064-7473504:+","gi|262118295|ref|NP_001160044.1|",4488,0,"short transient receptor potential channel 6 [Bos taurus]","gi|982945319|ref|XM_015474582.1|",2730,0,"PREDICTED: Bos taurus transient receptor potential cation channel, subfamily C, member 6 (TRPC6), transcript variant X1, mRNA","Q9MYW0",1733,0,"Short transient receptor potential channel 6",".",".",".",".","pfam08344","TRP_2","Transient receptor ion channel II. This domain is found in the transient receptor ion channel (Trp) family of proteins. There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors. This domain does not tend to appear with the TRP domain (pfam06011) but is often found to the C-terminus of Ankyrin repeats (pfam00023).","GO:0006828|manganese ion transport;GO:0051928|positive regulation of calcium ion transport;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0032414|positive regulation of ion transmembrane transporter activity;GO:0051480|cytosolic calcium ion homeostasis;GO:0007338|single fertilization;","GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0036057|slit diaphragm;","GO:0005261|cation channel activity;GO:0070679|inositol 1,4,5 trisphosphate binding;GO:0042803|protein homodimerization activity;GO:0015279|store-operated calcium channel activity;","K04969","TRPC6; transient receptor potential cation channel subfamily C member 6"]
["gene1845",68,381,250,219.363224284599,18,39,22,28.9817443598876,7.56901384404626,2.92010534578799,{"v":1.22350082939089e-07,"d":"1.22E-07"},{"v":1.00022069235964e-05,"d":"1.00E-05"},"up","yes","LYPD6","protein_coding","chrNC_037329.1:46621542-46753883:-","gi|426221122|ref|XP_004004760.1|",774,{"v":7e-92,"d":"7.00E-92"},"PREDICTED: ly6/PLAUR domain-containing protein 6 [Ovis aries]","gi|965921748|ref|XM_012137899.2|",2967,0,"PREDICTED: Ovis aries LY6/PLAUR domain containing 6 (LYPD6), transcript variant X3, mRNA","Q86Y78",296,{"v":5e-91,"d":"5.00E-91"},"Ly6/PLAUR domain-containing protein 6",".",".",".",".","pfam01064","Activin_recp","Activin types I and II receptor domain. This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.",".","GO:0031225|anchored component of membrane;GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0045121|membrane raft;GO:0043005|neuron projection;GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0030550|acetylcholine receptor inhibitor activity;",".","."]
["gene18460",35007,35219,57386,38290.0086621367,5750,15215,8294,10726.7915175687,3.56956771271484,1.83574936935671,0.00218452831412504,0.0328208411428655,"up","yes","SLN","protein_coding","chrNC_037342.1:17267311-17271854:-","gi|803339362|ref|XP_012027737.1|",341,{"v":3e-37,"d":"3.00E-37"},"PREDICTED: sarcolipin isoform X2 [Ovis aries musimon]","gi|329755232|ref|NM_001206365.1|",653,0,"Bos taurus sarcolipin (SLN), mRNA",".",".",".",".",".",".",".",".","pfam05366","Sarcolipin","Sarcolipin. Sarcolipin is a 31 amino acid integral membrane protein that regulates Ca-ATPase activity in skeletal muscle.",".",".",".",".","."]
["gene18498",6,18,73,29.8825369001273,3,5,5,4.76110655776808,6.27638481465445,2.64993380883471,0.000711635389402566,0.01397361961118,"up","yes","POU2AF1","protein_coding","chrNC_037342.1:21635821-21660814:-","gi|884923150|ref|XP_013011035.1|",1247,{"v":2e-161,"d":"2.00E-161"},"PREDICTED: POU domain class 2-associating factor 1 isoform X1 [Cavia porcellus]","gi|115496321|ref|NM_001075915.1|",2703,0,"Bos taurus POU class 2 associating factor 1 (POU2AF1), mRNA","Q2KJA4",476,{"v":4e-160,"d":"4.00E-160"},"POU domain class 2-associating factor 1",".",".",".",".","pfam09310","PD-C2-AF1","POU domain, class 2, associating factor 1. Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germinal centres.",".","GO:0090575|RNA polymerase II transcription factor complex;","GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001105|RNA polymerase II transcription coactivator activity;",".","."]
["gene18544",14047,13901,14192,12575.2482906553,5113,5210,5382,5765.83756520566,2.18099246613215,1.12498478644241,{"v":5.11608851938415e-05,"d":"5.12E-05"},0.00165121178220078,"up","yes","ZBTB16","protein_coding","chrNC_037342.1:24581860-24786657:+","gi|82697379|ref|NP_001032553.1|",3441,0,"zinc finger and BTB domain-containing protein 16 [Bos taurus]","gi|982945555|ref|XM_005215850.3|",7736,0,"PREDICTED: Bos taurus zinc finger and BTB domain containing 16 (ZBTB16), transcript variant X2, mRNA","Q05516",1282,0,"Zinc finger and BTB domain-containing protein 16",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0009952|anterior/posterior pattern specification;GO:0006915|apoptotic process;GO:0051216|cartilage development;GO:0007417|central nervous system development;GO:0042733|embryonic digit morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0009880|embryonic pattern specification;GO:0035136|forelimb morphogenesis;GO:0030097|hemopoiesis;GO:0048133|male germ-line stem cell asymmetric division;GO:0001823|mesonephros development;GO:0030099|myeloid cell differentiation;GO:0008285|negative regulation of cell proliferation;GO:0045638|negative regulation of myeloid cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0043065|positive regulation of apoptotic process;GO:0061036|positive regulation of cartilage development;GO:0032332|positive regulation of chondrocyte differentiation;GO:0045600|positive regulation of fat cell differentiation;GO:0051138|positive regulation of NK T cell differentiation;GO:0045778|positive regulation of ossification;GO:0045893|positive regulation of transcription, DNA-templated;GO:0043687|post-translational protein modification;GO:0034504|protein localization to nucleus;GO:0016567|protein ubiquitination;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0016604|nuclear body;GO:0016607|nuclear speck;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0016605|PML body;GO:0032991|macromolecular complex;GO:0017053|transcriptional repressor complex;","GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0008022|protein C-terminus binding;GO:0019904|protein domain specific binding;GO:0042803|protein homodimerization activity;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001206|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;","K10055","ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16"]
["gene18596",4009,8646,16026,8800.2169111,972,2782,1698,1997.19396518195,4.40629055791197,2.13956463181534,0.00133336903360016,0.0227390029274633,"up","yes","SCN4B","protein_coding","chrNC_037342.1:28825540-28845404:-","gi|742231326|ref|XP_010828947.1|",1240,{"v":1e-149,"d":"1.00E-149"},"PREDICTED: transmembrane protease serine 4 [Bison bison bison]","gi|116004048|ref|NM_001076912.1|",4329,0,"Bos taurus sodium channel, voltage gated, type IV beta subunit (SCN4B), mRNA","Q08E08",347,{"v":4e-108,"d":"4.00E-108"},"Sodium channel subunit beta-4",".",".",".",".","pfam11489","DUF3210","Protein of unknown function (DUF3210). This is a family of proteins conserved in yeasts. The function is not known. The Schizosaccharomyces pombe member is SPBC18E5.07 and the Saccharomyces cerevisiae member is AIM21.","GO:0086016|AV node cell action potential;GO:0086002|cardiac muscle cell action potential involved in contraction;GO:0010765|positive regulation of sodium ion transport;GO:0086091|regulation of heart rate by cardiac conduction;GO:2000649|regulation of sodium ion transmembrane transporter activity;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;","GO:0014704|intercalated disc;GO:0031226|intrinsic component of plasma membrane;GO:0001518|voltage-gated sodium channel complex;","GO:0044325|ion channel binding;GO:0017080|sodium channel regulator activity;GO:0005244|voltage-gated ion channel activity;GO:0086006|voltage-gated sodium channel activity involved in cardiac muscle cell action potential;","K04848","SCN4B; voltage-gated sodium channel type IV beta"]
["gene18627",715,3767,3219,2409.4826504936,315,453,437,441.727469414523,5.45468148876317,2.44749495676929,{"v":7.67941723830269e-22,"d":"7.68E-22"},{"v":6.63943797654588e-19,"d":"6.64E-19"},"up","yes","SLC37A4","protein_coding","chrNC_037342.1:29594433-29601229:-","gi|329112559|ref|NP_001192279.1|",2226,0,"glucose-6-phosphate translocase isoform 1 [Bos taurus]","gi|982945720|ref|XM_010812434.2|",3290,0,"PREDICTED: Bos taurus solute carrier family 37 (glucose-6-phosphate transporter), member 4 (SLC37A4), transcript variant X3, mRNA","O43826",768,0,"Glucose-6-phosphate exchanger SLC37A4","CPn0665",217,{"v":4e-60,"d":"4.00E-60"},"COG2271","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0008643|carbohydrate transport;GO:0006094|gluconeogenesis;GO:0042593|glucose homeostasis;GO:0006006|glucose metabolic process;GO:0015760|glucose-6-phosphate transport;GO:0035435|phosphate ion transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016020|membrane;","GO:0061513|glucose 6-phosphate:inorganic phosphate antiporter activity;GO:0015152|glucose-6-phosphate transmembrane transporter activity;GO:0005215|transporter activity;","K08171","SLC37A4; MFS transporter, OPA family, solute carrier family 37 (glycerol-6-phosphate transporter), member 4"]
["gene18630",810,1813,1995,1417.96463328704,345,377,438,425.410429765325,3.33316847466398,1.73689424016627,{"v":2.16498250431956e-11,"d":"2.16E-11"},{"v":4.0637576204435e-09,"d":"4.06E-09"},"up","yes","HMBS","protein_coding","chrNC_037342.1:29666771-29674064:+","gi|114051169|ref|NP_001039672.1|",1912,0,"porphobilinogen deaminase [Bos taurus]","gi|114051168|ref|NM_001046207.1|",1476,0,"Bos taurus hydroxymethylbilane synthase (HMBS), mRNA","Q2KIN5",741,0,"Porphobilinogen deaminase","alr1878",309,{"v":7e-100,"d":"7.00E-100"},"COG0181","pfam01379","Porphobil_deam","Porphobilinogen deaminase, dipyromethane cofactor binding domain.","GO:0006783|heme biosynthetic process;GO:0018160|peptidyl-pyrromethane cofactor linkage;GO:0006782|protoporphyrinogen IX biosynthetic process;","GO:0005737|cytoplasm;","GO:0004418|hydroxymethylbilane synthase activity;","K01749","hemC, HMBS; hydroxymethylbilane synthase [EC:2.5.1.61]"]
["gene18645",11617,19341,17262,14667.581415204,6524,5634,6408,6819.18525326109,2.15092872102127,1.1049597165169,0.000115423440961082,0.00326165483247001,"up","yes","USP2","protein_coding","chrNC_037342.1:29935374-29962286:-","gi|528977216|ref|XP_005216022.1|",3208,0,"PREDICTED: ubiquitin carboxyl-terminal hydrolase 2 isoform X1 [Bos taurus]","gi|742230631|ref|XM_010830466.1|",5342,0,"PREDICTED: Bison bison bison ubiquitin specific peptidase 2 (USP2), transcript variant X1, mRNA","Q2KHV7",1019,0,"Ubiquitin carboxyl-terminal hydrolase 2",".",".",".",".","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0007049|cell cycle;GO:0048512|circadian behavior;GO:0032922|circadian regulation of gene expression;GO:0043153|entrainment of circadian clock by photoperiod;GO:0045475|locomotor rhythm;GO:0007517|muscle organ development;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045931|positive regulation of mitotic cell cycle;GO:0016579|protein deubiquitination;GO:0050821|protein stabilization;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005938|cell cortex;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0030332|cyclin binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0004843|ubiquitin-specific protease activity;GO:0031625|ubiquitin protein ligase binding;","K11833","USP2_21; ubiquitin carboxyl-terminal hydrolase 2/21 [EC:3.4.19.12]"]
["gene18651",277,362,251,267.91396651205,103,99,126,120.312466564106,2.22681800284842,1.15498365192117,0.000496002372452162,0.0104981036264337,"up","yes","NECTIN1","protein_coding","chrNC_037342.1:30213687-30281883:-","gi|329664816|ref|NP_001192951.1|",2411,0,"poliovirus receptor-related protein 1 precursor [Bos taurus]","gi|329664815|ref|NM_001206022.1|",1722,0,"Bos taurus poliovirus receptor-related 1 (herpesvirus entry mediator C) (PVRL1), mRNA","Q9GL76",898,0,"Nectin-1",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0008037|cell recognition;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0046598|positive regulation of viral entry into host cell;GO:0051963|regulation of synapse assembly;GO:0019062|virion attachment to host cell;","GO:0005913|cell-cell adherens junction;GO:0005887|integral component of plasma membrane;GO:0045202|synapse;","GO:0050839|cell adhesion molecule binding;GO:0042803|protein homodimerization activity;GO:0005102|receptor binding;","K06081","PVRL1; poliovirus receptor-related protein 1"]
["gene18699",14,42,77,41.0612336302076,2,9,6,6.21626163199421,6.60545454182161,2.72365784120999,0.000204716038491612,0.005162159465941,"up","yes","OTOG","protein_coding","chrNC_037342.1:34871462-34959413:-","gi|747165291|ref|NP_001291257.1|",14658,0,"otogelin precursor [Bos taurus]","gi|747165290|ref|NM_001304328.1|",9863,0,"Bos taurus otogelin (OTOG), mRNA","Q6ZRI0",4826,0,"Otogelin",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.","GO:0008344|adult locomotory behavior;GO:0046373|L-arabinose metabolic process;GO:0007605|sensory perception of sound;","GO:0016324|apical plasma membrane;GO:0005615|extracellular space;","GO:0046556|alpha-L-arabinofuranosidase activity;GO:0005198|structural molecule activity;",".","."]
["gene18713",2975,4619,3575,3387.04192999194,871,1458,1001,1221.95374347934,2.77182499588553,1.47083617322613,{"v":3.77493288259345e-05,"d":"3.77E-05"},0.0012807178349285,"up","yes","SOX6","protein_coding","chrNC_037342.1:35834420-36548505:+","gi|803265051|ref|XP_011992261.1|",3887,0,"PREDICTED: transcription factor SOX-6 isoform X21 [Ovis aries musimon]","gi|982945875|ref|XM_015474667.1|",8977,0,"PREDICTED: Bos taurus SRY-box 6 (SOX6), transcript variant X9, mRNA","P35712",1426,0,"Transcription factor SOX-6",".",".",".",".","pfam00505","HMG_box","HMG (high mobility group) box.","GO:0048708|astrocyte differentiation;GO:0055007|cardiac muscle cell differentiation;GO:0051216|cartilage development;GO:0000902|cell morphogenesis;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0048821|erythrocyte development;GO:0016458|gene silencing;GO:0001701|in utero embryonic development;GO:0007517|muscle organ development;GO:2000726|negative regulation of cardiac muscle cell differentiation;GO:0021778|oligodendrocyte cell fate specification;GO:0061036|positive regulation of cartilage development;GO:0032332|positive regulation of chondrocyte differentiation;GO:2000741|positive regulation of mesenchymal stem cell differentiation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0009791|post-embryonic development;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09269","SOX5_6_13; transcription factor SOX5/6/13 (SOX group D)"]
["gene18716",43,219,79,107.239579985241,10,20,13,15.7700798315299,6.8001925881714,2.76557560549023,{"v":2.00745403058443e-08,"d":"2.01E-08"},{"v":1.96820175074242e-06,"d":"1.97E-06"},"up","yes","INSC","protein_coding","chrNC_037342.1:37342408-37482577:-","gi|329664594|ref|NP_001192412.1|",2561,0,"protein inscuteable homolog [Bos taurus]","gi|982945958|ref|XM_005216065.3|",2210,0,"PREDICTED: Bos taurus inscuteable homolog (Drosophila) (INSC), transcript variant X1, mRNA","Q1MX18",956,0,"Protein inscuteable homolog",".",".",".",".","pfam01560","HCV_NS1","Hepatitis C virus non-structural protein E2/NS1. The hypervariable region of the E2/NS1 region of hepatitis C virus varies greatly between viral isolates. E2 is thought to encode a structurally unconstrained envelope protein.","GO:0030154|cell differentiation;GO:0007399|nervous system development;GO:0031647|regulation of protein stability;","GO:0005938|cell cortex;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0030674|protein binding, bridging;GO:0019904|protein domain specific binding;",".","."]
["gene18744",17538,12456,11575,12207.7946488446,4423,5693,4881,5504.34516168492,2.21784686284239,1.1491597542079,{"v":2.86868399137121e-05,"d":"2.87E-05"},0.00102052896456125,"up","yes","TEAD1","protein_coding","chrNC_037342.1:39740865-40015346:-","gi|635015109|ref|XP_008004664.1|",2552,0,"PREDICTED: transcriptional enhancer factor TEF-1 isoform X5 [Chlorocebus sabaeus]","gi|982995116|ref|XM_005194599.3|",9336,0,"PREDICTED: Bos taurus TEA domain transcription factor 1 (TEAD1), transcript variant X1, mRNA","P28347",821,0,"Transcriptional enhancer factor TEF-1",".",".",".",".","pfam01285","TEA","TEA/ATTS domain family.","GO:0048568|embryonic organ development;GO:0035329|hippo signaling;GO:1902895|positive regulation of pri-miRNA transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0065003|macromolecular complex assembly;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0005654|nucleoplasm;GO:0071148|TEAD-1-YAP complex;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001085|RNA polymerase II transcription factor binding;GO:0043565|sequence-specific DNA binding;GO:0001223|transcription coactivator binding;GO:0000982|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001134|transcription factor activity, transcription factor recruiting;","K09448","TEAD; transcriptional enhancer factor"]
["gene18756",1399,308,385,583.790782468609,225,221,204,238.840542282727,2.44427004263601,1.28940368272216,{"v":1.07444195907841e-05,"d":"1.07E-05"},0.000456854002003967,"up","yes","GALNT18","protein_coding","chrNC_037342.1:41064111-41419990:+","gi|635015168|ref|XP_008004895.1|",2873,0,"PREDICTED: polypeptide N-acetylgalactosaminyltransferase 18 isoform X5 [Chlorocebus sabaeus]","gi|742226148|ref|XM_010829347.1|",2100,0,"PREDICTED: Bison bison bison polypeptide N-acetylgalactosaminyltransferase 18 (GALNT18), mRNA","Q6P9A2",1087,0,"Polypeptide N-acetylgalactosaminyltransferase 18",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0006493|protein O-linked glycosylation;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["gene18799",1925,1045,1051,1166.94954260271,473,527,560,572.339573048703,2.03891115965767,1.02779891497511,{"v":4.94865593613959e-05,"d":"4.95E-05"},0.0015989819084258,"up","yes","ST5","protein_coding","chrNC_037342.1:43700109-43870871:+","gi|594054823|ref|XP_006051660.1|",4868,0,"PREDICTED: suppression of tumorigenicity 5 protein isoform X2 [Bubalus bubalis]","gi|982945912|ref|XM_010812501.2|",4494,0,"PREDICTED: Bos taurus suppression of tumorigenicity 5 (ST5), transcript variant X1, mRNA","P78524",1735,0,"Suppression of tumorigenicity 5 protein",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0070374|positive regulation of ERK1 and ERK2 cascade;",".","GO:0017112|Rab guanyl-nucleotide exchange factor activity;",".","."]
["gene18838",5802,3508,4130,3930.18198558188,706,1239,852,1026.12677061061,3.8301134890411,1.93738714088418,{"v":1.52625835424963e-07,"d":"1.53E-07"},{"v":1.21297150710575e-05,"d":"1.21E-05"},"up","yes","PPFIBP2","protein_coding","chrNC_037342.1:45058387-45217377:-","gi|965883095|ref|XP_014944237.1|",5043,0,"PREDICTED: liprin-beta-2 isoform X16 [Ovis aries musimon]","gi|982995206|ref|XM_015466521.1|",5948,0,"PREDICTED: Bos taurus liprin-beta-2 (LOC614705), mRNA","Q8ND30",1420,0,"Liprin-beta-2",".",".",".",".","pfam02994","Transposase_22","L1 transposable element.",".","GO:0005829|cytosol;GO:0005615|extracellular space;GO:0005622|intracellular;","GO:0042802|identical protein binding;",".","."]
["gene18881",99,52,41,55.4350067434599,17,7,7,11.4497807352418,4.84157802016539,2.27547734312367,0.00120856405273234,0.0210125173604549,"up","yes","DNHD1","protein_coding","chrNC_037342.1:46489290-46551964:-","gi|982946149|ref|XP_015330206.1|",22120,0,"PREDICTED: LOW QUALITY PROTEIN: dynein heavy chain domain-containing protein 1 [Bos taurus]","gi|982995245|ref|XM_015466531.1|",14373,0,"PREDICTED: Bos taurus dynein heavy chain domain 1 (DNHD1), mRNA","Q96M86",6027,0,"Dynein heavy chain domain-containing protein 1","YKR054c",102,{"v":5e-20,"d":"5.00E-20"},"COG5245","pfam08393","DHC_N2","Dynein heavy chain, N-terminal region 2. Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.","GO:0003341|cilium movement;GO:0036159|inner dynein arm assembly;","GO:0070062|extracellular exosome;GO:0036156|inner dynein arm;","GO:0005524|ATP binding;GO:0008569|ATP-dependent microtubule motor activity, minus-end-directed;GO:0045505|dynein intermediate chain binding;GO:0045503|dynein light chain binding;GO:0051959|dynein light intermediate chain binding;",".","."]
["gene18977",0,26,0,8.52065965937138,0,0,0,0,"Inf","Inf",0.00158424756113207,0.0259771075670454,"up","yes","UBQLN3","protein_coding","chrNC_037342.1:48059149-48061840:+","gi|942088218|ref|XP_005911734.2|",2769,0,"PREDICTED: ubiquilin-3 [Bos mutus]","gi|84370210|ref|NM_001038583.1|",2359,0,"Bos taurus ubiquilin 3 (UBQLN3), mRNA","Q9H347",841,0,"Ubiquilin-3","ECU10g1730",67,{"v":3e-11,"d":"3.00E-11"},"COG5272","pfam00240","ubiquitin","Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.",".",".",".","K04523","UBQLN, DSK2; ubiquilin"]
["gene19197",3982,6916,6366,5259.43351802376,1712,2370,2105,2269.49943909558,2.31744208763484,1.21253328667131,{"v":2.48021807836515e-06,"d":"2.48E-06"},0.000130079231606316,"up","yes","STIM1","protein_coding","chrNC_037342.1:51012415-51216983:-","gi|741952243|ref|XP_010810962.1|",3466,0,"PREDICTED: stromal interaction molecule 1 isoform X2 [Bos taurus]","gi|982946348|ref|XM_010812660.2|",4196,0,"PREDICTED: Bos taurus stromal interaction molecule 1 (STIM1), transcript variant X2, mRNA","Q58CP9",1196,0,"Stromal interaction molecule 1",".",".",".",".","pfam04111","APG6","Autophagy protein Apg6. In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.","GO:0032237|activation of store-operated calcium channel activity;GO:0006874|cellular calcium ion homeostasis;GO:0005513|detection of calcium ion;GO:0070166|enamel mineralization;GO:0051924|regulation of calcium ion transport;GO:2001256|regulation of store-operated calcium entry;GO:0002115|store-operated calcium entry;","GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;GO:0005887|integral component of plasma membrane;GO:0005874|microtubule;GO:0005886|plasma membrane;GO:0033017|sarcoplasmic reticulum membrane;","GO:0005246|calcium channel regulator activity;GO:0005509|calcium ion binding;GO:0051010|microtubule plus-end binding;","K16059","STIM1; stromal interaction molecule 1"]
["gene19239",1644,1676,1760,1518.25350685924,249,519,355,411.680178162458,3.68794415518374,1.88281680987531,{"v":1.64993885730837e-05,"d":"1.65E-05"},0.000648407789777755,"up","yes","P2RY2","protein_coding","chrNC_037342.1:52709682-52730947:+","gi|982946310|ref|XP_015330243.1|",1721,0,"PREDICTED: P2Y purinoceptor 2 isoform X1 [Bos taurus]","gi|965885491|ref|XM_012155264.2|",6725,0,"PREDICTED: Ovis aries musimon P2Y purinoceptor 2-like (LOC105611728), transcript variant X3, mRNA","P41231",568,0,"P2Y purinoceptor 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006873|cellular ion homeostasis;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007200|phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0070257|positive regulation of mucus secretion;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0045028|G-protein coupled purinergic nucleotide receptor activity;GO:0038023|signaling receptor activity;","K04269","P2RY2; purinergic receptor P2Y, G protein-coupled, 2"]
["gene19243",98,219,250,174.091657358218,32,16,35,30.4664310856109,5.71421236931293,2.51455465518593,{"v":5.79751930683124e-08,"d":"5.80E-08"},{"v":5.16903197947506e-06,"d":"5.17E-06"},"up","yes","RELT","protein_coding","chrNC_037342.1:52862861-52880888:+","gi|528915694|ref|XP_582052.5|",1575,0,"PREDICTED: tumor necrosis factor receptor superfamily member 19L [Bos taurus]","gi|982995530|ref|XM_005194658.2|",2434,0,"PREDICTED: Bos taurus RELT tumor necrosis factor receptor (RELT), transcript variant X2, mRNA","Q9N092",508,{"v":3e-165,"d":"3.00E-165"},"Tumor necrosis factor receptor superfamily member 19L",".",".",".",".","pfam12606","RELT","tumor necrosis factor receptor superfamily member 19. This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 49 and 288 amino acids in length. There are two completely conserved residues (K and Y) that may be functionally important. The members of tumor necrosis factor receptor (TNFR) superfamily have been designated as the \"guardians of the immune system\" due to their roles in immune cell proliferation, differentiation, activation, and death (apoptosis). The messenger RNA of RELT is especially abundant in hematologic tissues such as spleen, lymph node, and peripheral blood leukocytes as well as in leukemias and lymphomas. RELT is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1.",".","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".","K05156","TNFRSF19L, RELT; tumor necrosis factor receptor superfamily member 19-like"]
["gene19269",316,66,944,393.909131793926,0,4,2,2.18989605286426,179.875721168918,7.49085666089449,{"v":1.21825335610414e-09,"d":"1.22E-09"},{"v":1.5871226713702e-07,"d":"1.59E-07"},"up","yes","CHRDL2","protein_coding","chrNC_037342.1:54008943-54042768:-","gi|528978052|ref|XP_005216309.1|",2177,0,"PREDICTED: chordin-like protein 2 isoform X1 [Bos taurus]","gi|741952378|ref|XM_005216252.2|",1852,0,"PREDICTED: Bos taurus chordin-like 2 (CHRDL2), transcript variant X1, mRNA","Q6WN34",612,0,"Chordin-like protein 2",".",".",".",".","pfam00093","VWC","von Willebrand factor type C domain. The high cutoff was used to prevent overlap with pfam00094.","GO:0051216|cartilage development;GO:0030154|cell differentiation;GO:0001503|ossification;","GO:0005737|cytoplasm;GO:0005615|extracellular space;",".","K17280","CHRDL2; chordin-like protein 2"]
["gene19292",4253,2550,5170,3531.9295539951,1758,1168,1758,1720.3161210255,2.0530700787072,1.03778287268657,0.000428127074042181,0.00935290470865043,"up","yes","SERPINH1","protein_coding","chrNC_037342.1:54738093-54748404:+","gi|114051505|ref|NP_001039528.1|",1994,0,"serpin H1 precursor [Bos taurus]","gi|742156189|ref|XM_010847562.1|",2124,0,"PREDICTED: Bison bison bison serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) (SERPINH1), transcript variant X2, mRNA","Q2KJH6",772,0,"Serpin H1","all0778",127,{"v":1e-30,"d":"1.00E-30"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0003433|chondrocyte development involved in endochondral bone morphogenesis;GO:0032964|collagen biosynthetic process;GO:0030199|collagen fibril organization;GO:0051604|protein maturation;","GO:0005783|endoplasmic reticulum;GO:0005788|endoplasmic reticulum lumen;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0045121|membrane raft;","GO:0005518|collagen binding;GO:0004867|serine-type endopeptidase inhibitor activity;GO:0051082|unfolded protein binding;","K09501","SERPINH1, HSP47; serpin peptidase inhibitor, clade H, member 1"]
["gene19401",40,54,98,58.2196042441984,7,18,15,14.6367461999028,3.97763296903959,1.99191015948594,0.000427720253985898,0.00935117744557215,"up","yes","EHF","protein_coding","chrNC_037342.1:65186343-65274384:+","gi|528978332|ref|XP_005216427.1|",1055,{"v":2e-126,"d":"2.00E-126"},"PREDICTED: ETS homologous factor isoform X1 [Bos taurus]","gi|982946713|ref|XM_005216373.3|",4313,0,"PREDICTED: Bos taurus ets homologous factor (EHF), transcript variant X3, mRNA","Q32LN0",405,{"v":4e-126,"d":"4.00E-126"},"ETS homologous factor",".",".",".",".","pfam00178","Ets","Ets-domain.","GO:0030154|cell differentiation;GO:0030855|epithelial cell differentiation;GO:0050673|epithelial cell proliferation;GO:0006357|regulation of transcription from RNA polymerase II promoter;","GO:0005794|Golgi apparatus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K17102","EHF; ETS homologous factor"]
["gene19405",4858,5641,4365,4455.34904365406,1411,2273,1719,1982.061914815,2.24783545375266,1.16853643113555,0.000236332638059796,0.0057483431342575,"up","yes","PDHX","protein_coding","chrNC_037342.1:65427232-65502625:+","gi|742237006|ref|XP_010830147.1|",2393,0,"PREDICTED: pyruvate dehydrogenase protein X component, mitochondrial [Bison bison bison]","gi|115496094|ref|NM_001075751.1|",2284,0,"Bos taurus pyruvate dehydrogenase complex component X (PDHX), mRNA","P22439",926,0,"Pyruvate dehydrogenase protein X component","RP530",288,{"v":7e-88,"d":"7.00E-88"},"COG0508","pfam00198","2-oxoacid_dh","2-oxoacid dehydrogenases acyltransferase (catalytic domain). These proteins contain one to three copies of a lipoyl binding domain followed by the catalytic domain.",".","GO:0005759|mitochondrial matrix;GO:0045254|pyruvate dehydrogenase complex;","GO:0034604|pyruvate dehydrogenase (NAD+) activity;GO:0016746|transferase activity, transferring acyl groups;","K13997","PDHX; dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex"]
["gene19447",1672,1827,2147,1693.89239925718,518,603,558,616.328246573314,2.74836081045278,1.45857141655801,{"v":4.65077732430585e-09,"d":"4.65E-09"},{"v":5.24471651540594e-07,"d":"5.24E-07"},"up","yes","CD82","protein_coding","chrNC_037342.1:74642880-74699203:+","gi|148237302|ref|NP_001091459.1|",1357,{"v":2e-180,"d":"2.00E-180"},"CD82 antigen [Bos taurus]","gi|148237301|ref|NM_001097990.1|",1678,0,"Bos taurus CD82 molecule (CD82), mRNA","P27701",411,{"v":8e-137,"d":"8.00E-137"},"CD82 antigen",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0007166|cell surface receptor signaling pathway;","GO:0070062|extracellular exosome;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;",".","K06509","KAI1, CD82, TSPAN27; CD82 antigen"]
["gene19450",1555,399,379,652.42758642121,245,216,243,258.558908891154,2.52332278635915,1.33532476933167,{"v":3.50008184378462e-06,"d":"3.50E-06"},0.000173671017539163,"up","yes","TSPAN18","protein_coding","chrNC_037342.1:74788769-75004308:+","gi|124249240|ref|NP_001074389.1|",965,{"v":2e-116,"d":"2.00E-116"},"tetraspanin-18 [Bos taurus]","gi|982995668|ref|XR_001498135.1|",3443,0,"PREDICTED: Bos taurus tetraspanin 18 (TSPAN18), transcript variant X1, misc_RNA","Q58CY8",376,{"v":8e-118,"d":"8.00E-118"},"Tetraspanin-18",".",".",".",".","pfam00335","Tetraspannin","Tetraspanin family.","GO:0007166|cell surface receptor signaling pathway;","GO:0005887|integral component of plasma membrane;",".","K17353","TSPAN18; tetraspanin-18"]
["gene19457",1070,193,360,452.680163600535,151,196,212,204.894797491936,2.20932971037661,1.14360873604492,0.000198135753282972,0.00502936937448086,"up","yes","CHST1","protein_coding","chrNC_037342.1:75702158-75720969:-","gi|139948894|ref|NP_001077117.1|",2138,0,"carbohydrate sulfotransferase 1 precursor [Bos taurus]","gi|594035465|ref|XM_006042347.1|",4630,0,"PREDICTED: Bubalus bubalis carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (CHST1), transcript variant X3, mRNA","O43916",813,0,"Carbohydrate sulfotransferase 1",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.","GO:0006012|galactose metabolic process;GO:0006954|inflammatory response;GO:0018146|keratan sulfate biosynthetic process;GO:0042339|keratan sulfate metabolic process;GO:0005976|polysaccharide metabolic process;GO:0006790|sulfur compound metabolic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0045130|keratan sulfotransferase activity;GO:0001517|N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008146|sulfotransferase activity;","K01022","CHST1; keratan sulfate 6-sulfotransferase 1 [EC:2.8.2.21]"]
["gene19461",1030,2309,1727,1555.54111647051,525,530,607,609.842202202587,2.55072723870586,1.35090863300324,{"v":1.83051719655149e-07,"d":"1.83E-07"},{"v":1.40393779932286e-05,"d":"1.40E-05"},"up","yes","CRY2","protein_coding","chrNC_037342.1:75880414-75915194:+","gi|577019500|ref|NP_001276715.1|",3010,0,"cryptochrome-2 [Bos taurus]","gi|577019499|ref|NM_001289786.1|",2536,0,"Bos taurus cryptochrome circadian clock 2 (CRY2), mRNA","Q49AN0",1020,0,"Cryptochrome-2","SPy1505",200,{"v":5e-55,"d":"5.00E-55"},"COG0415","pfam03441","FAD_binding_7","FAD binding domain of DNA photolyase.","GO:0009785|blue light signaling pathway;GO:0032922|circadian regulation of gene expression;GO:0007623|circadian rhythm;GO:0043153|entrainment of circadian clock by photoperiod;GO:0042593|glucose homeostasis;GO:0042754|negative regulation of circadian rhythm;GO:2000323|negative regulation of glucocorticoid receptor signaling pathway;GO:0032515|negative regulation of phosphoprotein phosphatase activity;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0018298|protein-chromophore linkage;GO:0042752|regulation of circadian rhythm;GO:2000118|regulation of sodium-dependent phosphate transport;GO:0009416|response to light stimulus;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005576|extracellular region;GO:0016607|nuclear speck;GO:0005634|nucleus;","GO:0009882|blue light photoreceptor activity;GO:0003684|damaged DNA binding;GO:0003677|DNA binding;GO:0071949|FAD binding;GO:0019902|phosphatase binding;GO:0003697|single-stranded DNA binding;GO:0000976|transcription regulatory region sequence-specific DNA binding;","K02295","CRY; cryptochrome"]
["gene19467",468,432,474,409.121366586835,117,72,114,111.304880802541,3.6756821770703,1.87801202740297,{"v":1.57060087654346e-08,"d":"1.57E-08"},{"v":1.60612235156493e-06,"d":"1.61E-06"},"up","yes","CREB3L1","protein_coding","chrNC_037342.1:76283432-76319470:+","gi|300797291|ref|NP_001179270.1|",2317,0,"cyclic AMP-responsive element-binding protein 3-like protein 1 [Bos taurus]","gi|300797290|ref|NM_001192341.1|",1757,0,"Bos taurus cAMP responsive element binding protein 3-like 1 (CREB3L1), mRNA","Q96BA8",839,0,"Cyclic AMP-responsive element-binding protein 3-like protein 1",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0030968|endoplasmic reticulum unfolded protein response;GO:0070278|extracellular matrix constituent secretion;GO:0007275|multicellular organismal development;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;GO:0010629|negative regulation of gene expression;GO:1903671|negative regulation of sprouting angiogenesis;GO:0045892|negative regulation of transcription, DNA-templated;GO:0001649|osteoblast differentiation;GO:0032967|positive regulation of collagen biosynthetic process;GO:1990440|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0000790|nuclear chromatin;GO:0005634|nucleus;","GO:0035497|cAMP response element binding;GO:0003682|chromatin binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0046332|SMAD binding;GO:0044212|transcription regulatory region DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09048","CREB3; cyclic AMP-responsive element-binding protein 3"]
["gene19469",98,22,36,43.8072449623854,12,12,5,10.6939323523581,4.09645802114369,2.03437703074083,0.000948289666384634,0.0173115747553657,"up","yes","MDK","protein_coding","chrNC_037342.1:76374900-76377926:+","gi|742134602|ref|XP_010840643.1|",903,{"v":3e-117,"d":"3.00E-117"},"PREDICTED: midkine isoform X1 [Bison bison bison]","gi|982946771|ref|XM_005216403.3|",1151,0,"PREDICTED: Bos taurus midkine (neurite growth-promoting factor 2) (MDK), transcript variant X2, mRNA","P21741",199,{"v":7e-61,"d":"7.00E-61"},"Midkine",".",".",".",".","pfam05196","PTN_MK_N","PTN/MK heparin-binding protein family, N-terminal domain.","GO:0030325|adrenal gland development;GO:0001662|behavioral fear response;GO:0030154|cell differentiation;GO:0016477|cell migration;GO:0021681|cerebellar granular layer development;GO:0021987|cerebral cortex development;GO:0030421|defecation;GO:0021542|dentate gyrus development;GO:0043524|negative regulation of neuron apoptotic process;GO:0007399|nervous system development;GO:0007219|Notch signaling pathway;GO:0051781|positive regulation of cell division;GO:0045893|positive regulation of transcription, DNA-templated;GO:0050795|regulation of behavior;GO:0042493|response to drug;GO:0051384|response to glucocorticoid;GO:0009611|response to wounding;GO:0007614|short-term memory;GO:0007165|signal transduction;","GO:0042995|cell projection;GO:0005737|cytoplasm;GO:0005576|extracellular region;","GO:0008083|growth factor activity;GO:0008201|heparin binding;","K06828","MDK; midkine"]
["gene19491",1017,1768,1245,1226.82512254177,383,540,462,508.095940260508,2.4145540740057,1.27175677306796,{"v":9.71854092321922e-07,"d":"9.72E-07"},{"v":5.95020796309801e-05,"d":"5.95E-05"},"up","yes","MADD","protein_coding","chrNC_037342.1:77140091-77180694:+","gi|982946933|ref|XP_015330385.1|",7927,0,"PREDICTED: MAP kinase-activating death domain protein isoform X3 [Bos taurus]","gi|982946932|ref|XM_015474899.1|",5842,0,"PREDICTED: Bos taurus MAP kinase activating death domain (MADD), transcript variant X8, mRNA","Q8WXG6",2856,0,"MAP kinase-activating death domain protein",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.","GO:0000187|activation of MAPK activity;GO:0007166|cell surface receptor signaling pathway;GO:0097194|execution phase of apoptosis;GO:0042981|regulation of apoptotic process;GO:0051726|regulation of cell cycle;GO:2001236|regulation of extrinsic apoptotic signaling pathway;GO:1902041|regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:0032483|regulation of Rab protein signal transduction;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005123|death receptor binding;GO:0030295|protein kinase activator activity;GO:0017112|Rab guanyl-nucleotide exchange factor activity;",".","."]
["gene19502",4418,7887,6847,5839.00462155944,2105,1870,2121,2238.67208025877,2.6082447148242,1.38307923471494,{"v":7.74444021441962e-08,"d":"7.74E-08"},{"v":6.6230790370689e-06,"d":"6.62E-06"},"up","yes","NDUFS3","protein_coding","chrNC_037342.1:77379153-77383886:+","gi|742134850|ref|XP_010840721.1|",1364,0,"PREDICTED: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [Bison bison bison]","gi|742134849|ref|XM_010842419.1|",871,0,"PREDICTED: Bison bison bison NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) (NDUFS3), mRNA","P23709",530,0,"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial","BMEI1156",216,{"v":3e-68,"d":"3.00E-68"},"COG0852","pfam00329","Complex1_30kDa","Respiratory-chain NADH dehydrogenase, 30 Kd subunit.","GO:0045333|cellular respiration;GO:0030308|negative regulation of cell growth;GO:2001243|negative regulation of intrinsic apoptotic signaling pathway;GO:0072593|reactive oxygen species metabolic process;","GO:0031966|mitochondrial membrane;GO:0005747|mitochondrial respiratory chain complex I;","GO:0008137|NADH dehydrogenase (ubiquinone) activity;GO:0003954|NADH dehydrogenase activity;","K03936","NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:1.6.5.3 1.6.99.3]"]
["gene19503",67,58,48,51.2112206751974,14,10,6,11.0684662832023,4.62676755431928,2.2100046206982,0.000211094524673112,0.00527385103629472,"up","yes","FAM180B","protein_coding","chrNC_037342.1:77384965-77387225:+","gi|729042237|ref|NP_001289865.1|",1042,{"v":1e-138,"d":"1.00E-138"},"protein FAM180B [Bos taurus]","gi|729042236|ref|NM_001302936.1|",1258,0,"Bos taurus family with sequence similarity 180 member B (FAM180B), mRNA","Q6P0A1",338,{"v":2e-113,"d":"2.00E-113"},"Protein FAM180B",".",".",".",".","pfam15173","FAM180","FAM180 family. This family of proteins is found in eukaryotes. Proteins in this family are typically between 117 and 182 amino acids in length. There are two conserved sequence motifs: ELAS and DFE. The function of this family is unknown.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene1956",141,10,16,44.9389993237014,5,0,2,2.5907862278309,17.345699479546,4.11650611454451,0.00216598441160751,0.0326453783663888,"up","yes","C1QL2","protein_coding","chrNC_037329.1:70918684-70920915:-","gi|694896055|ref|XP_009441449.1|",918,{"v":9e-117,"d":"9.00E-117"},"PREDICTED: complement C1q-like protein 2 [Pan troglodytes]","gi|329663397|ref|NM_001205836.1|",1649,0,"Bos taurus complement component 1, q subcomponent-like 2 (C1QL2), mRNA","Q7Z5L3",357,{"v":5e-118,"d":"5.00E-118"},"Complement C1q-like protein 2",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0051259|protein oligomerization;","GO:0005581|collagen trimer;GO:0005576|extracellular region;","GO:0042802|identical protein binding;",".","."]
["gene1958",1387,2560,2096,1844.16863230328,551,614,620,655.0797758924,2.81518175368948,1.49322806855123,{"v":3.46128454128533e-09,"d":"3.46E-09"},{"v":4.06394688260954e-07,"d":"4.06E-07"},"up","yes","STEAP3","protein_coding","chrNC_037329.1:71009624-71061343:+","gi|741916989|ref|XP_010800450.1|",2637,0,"PREDICTED: metalloreductase STEAP3 isoform X1 [Bos taurus]","gi|982913945|ref|XM_010802148.2|",4254,0,"PREDICTED: Bos taurus STEAP3 metalloreductase (STEAP3), transcript variant X1, mRNA","Q658P3",805,0,"Metalloreductase STEAP3","alr8074",68.2,{"v":1e-11,"d":"1.00E-11"},"COG2085","pfam03807","F420_oxidored","NADP oxidoreductase coenzyme F420-dependent.","GO:0006915|apoptotic process;GO:0007049|cell cycle;GO:0015677|copper ion import;GO:0098706|ferric iron import across plasma membrane;GO:0055072|iron ion homeostasis;GO:0009306|protein secretion;GO:0042981|regulation of apoptotic process;GO:0033572|transferrin transport;","GO:0005737|cytoplasm;GO:0010008|endosome membrane;GO:0005887|integral component of plasma membrane;GO:0005771|multivesicular body;","GO:0008823|cupric reductase activity;GO:0052851|ferric-chelate reductase (NADPH) activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0016723|oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor;","K10142","STEAP3, TSAP6; metalloreductase STEAP3 [EC:1.16.1.-]"]
["gene19677",340,330,291,286.131130042445,91,41,87,80.4640278308237,3.55601301297069,1.83026060361479,0.000156490721361455,0.00422268842172665,"up","yes","LRRC55","protein_coding","chrNC_037342.1:80380089-80390193:+","gi|440894801|gb|ELR47154.1|",1566,0,"Leucine-rich repeat-containing protein 55, partial [Bos mutus]","gi|982995823|ref|XM_866944.4|",4599,0,"PREDICTED: Bos taurus leucine rich repeat containing 55 (LRRC55), mRNA","Q3UY51",520,{"v":8e-170,"d":"8.00E-170"},"Leucine-rich repeat-containing protein 55","SPy1798",57.4,{"v":4e-07,"d":"4.00E-07"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007409|axonogenesis;GO:1903818|positive regulation of voltage-gated potassium channel activity;GO:0071805|potassium ion transmembrane transport;","GO:0005615|extracellular space;GO:0008076|voltage-gated potassium channel complex;","GO:0044325|ion channel binding;GO:0005249|voltage-gated potassium channel activity;",".","."]
["gene19678",718,137,251,309.112336135336,40,50,44,49.1829091488102,6.28495429581179,2.65190225340546,{"v":2.93305249415127e-14,"d":"2.93E-14"},{"v":8.99816351727202e-12,"d":"9.00E-12"},"up","yes","APLNR","protein_coding","chrNC_037342.1:80445007-80448574:-","gi|156523160|ref|NP_001095994.1|",1410,0,"apelin receptor [Bos taurus]","gi|402745620|ref|NM_001102524.2|",3562,0,"Bos taurus apelin receptor (APLNR), mRNA","O97666",462,{"v":4e-150,"d":"4.00E-150"},"Apelin receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007512|adult heart development;GO:0060976|coronary vasculature development;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007369|gastrulation;GO:0007507|heart development;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0045766|positive regulation of angiogenesis;GO:1903589|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:1904325|positive regulation of inhibitory G-protein coupled receptor phosphorylation;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:0001570|vasculogenesis;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;","K04174","APLNR; apelin receptor"]
["gene19822",0,30,0,9.83153037619775,0,0,0,0,"Inf","Inf",0.000693990117304085,0.0137447642062416,"up","yes","MS4A14","protein_coding","chrNC_037342.1:83214109-83241884:+","gi|115497374|ref|NP_001070009.1|",4330,0,"membrane-spanning 4-domains subfamily A member 14 [Bos taurus]","gi|115497373|ref|NM_001076541.1|",3003,0,"Bos taurus membrane spanning 4-domains A14 (MS4A14), mRNA","Q96JA4",431,{"v":6e-136,"d":"6.00E-136"},"Membrane-spanning 4-domains subfamily A member 14",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene19947",691,108,134,256.63846491162,77,85,98,95.3494293767565,2.69155742817881,1.42844120762184,{"v":5.1472939029129e-05,"d":"5.15E-05"},0.00165940612818088,"up","yes","NFASC","protein_coding","chrNC_037343.1:2605484-2806577:+","gi|528979229|ref|XP_005216760.1|",6048,0,"PREDICTED: neurofascin isoform X1 [Bos taurus]","gi|982996009|ref|XM_015466689.1|",10154,0,"PREDICTED: Bos taurus neurofascin (NFASC), transcript variant X1, mRNA","O94856",2063,0,"Neurofascin",".",".",".",".","pfam13882","Bravo_FIGEY","Bravo-like intracellular region. This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY. The function is not known.","GO:0007411|axon guidance;GO:0045162|clustering of voltage-gated sodium channels;GO:0042552|myelination;GO:0043312|neutrophil degranulation;GO:0030913|paranodal junction assembly;GO:0007422|peripheral nervous system development;GO:0071205|protein localization to juxtaparanode region of axon;GO:0002175|protein localization to paranode region of axon;GO:0072659|protein localization to plasma membrane;GO:0050808|synapse organization;GO:0019226|transmission of nerve impulse;","GO:0043194|axon initial segment;GO:0030425|dendrite;GO:0005925|focal adhesion;GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0043209|myelin sheath;GO:0033268|node of Ranvier;GO:0033010|paranodal junction;GO:0033270|paranode region of axon;GO:0005886|plasma membrane;GO:0097454|Schwann cell microvillus;","GO:0086080|protein binding involved in heterotypic cell-cell adhesion;GO:0019904|protein domain specific binding;","K06757","NFASC; neurofascin"]
["gene19954",79,89,63,69.1047720767578,19,16,21,20.553825474862,3.3621367546044,1.74937840725613,0.000751559681323817,0.0145473197203866,"up","yes","TMCC2","protein_coding","chrNC_037343.1:3006671-3044515:+","gi|116004483|ref|NP_001070603.1|",2522,0,"transmembrane and coiled-coil domains protein 2 [Bos taurus]","gi|116004482|ref|NM_001077135.1|",3602,0,"Bos taurus transmembrane and coiled-coil domain family 2 (TMCC2), mRNA","O75069",899,0,"Transmembrane and coiled-coil domains protein 2",".",".",".",".","pfam10267","Tmemb_cc2","Predicted transmembrane and coiled-coil 2 protein. This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.","GO:0042982|amyloid precursor protein metabolic process;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;",".",".","."]
["gene19982",282,46,50,103.92684771172,35,29,43,39.2463568606542,2.64806356627486,1.40493775418773,0.00208887202701006,0.0317526636831489,"up","yes","DYRK3","protein_coding","chrNC_037343.1:4423644-4433850:+","gi|154152047|ref|NP_001093768.1|",2707,0,"dual specificity tyrosine-phosphorylation-regulated kinase 3 [Bos taurus]","gi|742179745|ref|XM_010854207.1|",1988,0,"PREDICTED: Bison bison bison dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (DYRK3), transcript variant X2, mRNA","O43781",977,0,"Dual specificity tyrosine-phosphorylation-regulated kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0030218|erythrocyte differentiation;GO:0043066|negative regulation of apoptotic process;GO:0043518|negative regulation of DNA damage response, signal transduction by p53 class mediator;GO:0006468|protein phosphorylation;GO:0080135|regulation of cellular response to stress;GO:1903432|regulation of TORC1 signaling;GO:0035617|stress granule disassembly;","GO:0005737|cytoplasm;GO:0010494|cytoplasmic stress granule;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;GO:0004713|protein tyrosine kinase activity;","K18669","DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2/3/4 [EC:2.7.12.1]"]
["gene19995",1709,300,529,706.187759693749,285,312,290,325.706164878839,2.16817437261725,1.11648078823881,{"v":8.92714390774095e-05,"d":"8.93E-05"},0.00265444151118354,"up","yes","PFKFB2","protein_coding","chrNC_037343.1:4872008-4900741:+","gi|528979102|ref|XP_005216711.1|",2835,0,"PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X1 [Bos taurus]","gi|741953432|ref|XM_010813015.1|",4062,0,"PREDICTED: Bos taurus 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2), transcript variant X3, mRNA","P26285",1082,0,"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2","YJL155c_2",243,{"v":3e-71,"d":"3.00E-71"},"COG0406","pfam01591","6PF2K","6-phosphofructo-2-kinase. This enzyme occurs as a bifunctional enzyme with fructose-2,6-bisphosphatase. The bifunctional enzyme catalyses both the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis. This enzyme contains a P-loop motif.","GO:0006003|fructose 2,6-bisphosphate metabolic process;GO:0006000|fructose metabolic process;GO:0006096|glycolytic process;","GO:0005654|nucleoplasm;","GO:0003873|6-phosphofructo-2-kinase activity;GO:0005524|ATP binding;GO:0004331|fructose-2,6-bisphosphate 2-phosphatase activity;GO:0019901|protein kinase binding;","K19029","PFKFB2; 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 2 [EC:2.7.1.105 3.1.3.46]"]
["gene20136",0,50,0,16.3858839603296,1,2,0,1.10774322816377,14.7921319162486,3.88675809075543,0.000710266390131518,0.0139563432347399,"up","yes","DNAH14","protein_coding","chrNC_037343.1:28066497-28442800:+","gi|803227204|ref|XP_011973904.1|",22887,0,"PREDICTED: dynein heavy chain 14, axonemal isoform X1 [Ovis aries musimon]","gi|965963341|ref|XM_015099170.1|",12561,0,"PREDICTED: Ovis aries dynein, axonemal, heavy chain 14 (DNAH14), transcript variant X1, mRNA","Q9C0G6",2370,0,"Dynein heavy chain 6, axonemal","YKR054c",352,{"v":7e-96,"d":"7.00E-96"},"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.","GO:0060271|cilium morphogenesis;GO:0001539|cilium or flagellum-dependent cell motility;GO:0007018|microtubule-based movement;","GO:0005858|axonemal dynein complex;GO:0005929|cilium;GO:0030286|dynein complex;GO:0005874|microtubule;","GO:0005524|ATP binding;GO:0008569|ATP-dependent microtubule motor activity, minus-end-directed;GO:0045505|dynein intermediate chain binding;GO:0045503|dynein light chain binding;GO:0051959|dynein light intermediate chain binding;","K10408","DNAH; dynein heavy chain, axonemal"]
["gene20174",0,27,0,8.84837733857797,0,0,0,0,"Inf","Inf",0.00128721883969803,0.0220839691614097,"up","yes","H3F3C","protein_coding","chrNC_037343.1:30668107-30671732:+","gi|115496015|ref|NP_001069659.1|",716,{"v":1e-93,"d":"1.00E-93"},"histone H3.3C-like [Bos taurus]","gi|402743743|ref|NM_001076191.2|",618,0,"Bos taurus histone H3-like (H3F3C), mRNA","Q3SZB8",280,{"v":5e-95,"d":"5.00E-95"},"Histone H3.3C-like","YNL031c",168,{"v":6e-52,"d":"6.00E-52"},"COG2036","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006334|nucleosome assembly;","GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;","K11253","H3; histone H3"]
["gene20195",2960,3866,2941,2941.6460532893,712,1131,915,1011.47601367341,2.9082706989818,1.54016156014564,{"v":2.36349167134676e-07,"d":"2.36E-07"},{"v":1.7574525534255e-05,"d":"1.76E-05"},"up","yes","ZBTB18","protein_coding","chrNC_037343.1:33149467-33158307:-","gi|759148861|ref|XP_011368371.1|",2858,0,"PREDICTED: zinc finger and BTB domain-containing protein 18 isoform X1 [Pteropus vampyrus]","gi|118151123|ref|NM_001078016.1|",3768,0,"Bos taurus zinc finger and BTB domain containing 18 (ZBTB18), mRNA","A0JN76",1043,0,"Zinc finger and BTB domain-containing protein 18",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0007519|skeletal muscle tissue development;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0043565|sequence-specific DNA binding;",".","."]
["gene20234",128,197,487,247.488392685879,124,82,105,114.34237712765,2.1644503018298,1.11400067505854,0.00147657956538188,0.0245613107967574,"up","yes","SELP","protein_coding","chrNC_037343.1:37241576-37285051:-","gi|151553726|gb|AAI49301.1|",3291,0,"Selectin P [Bos taurus]","gi|151553725|gb|BC149300.1|",2683,0,"Bos taurus selectin P, mRNA (cDNA clone MGC:148479 IMAGE:8195820), complete cds","P42201",1244,0,"P-selectin",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0050901|leukocyte tethering or rolling;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;GO:0070492|oligosaccharide binding;","K06496","SELP; selectin, platele"]
["gene20244",509,88,39,173.474127030528,0,3,4,2.5448542607813,68.1666253757374,6.09099365832958,{"v":1.76272896114853e-09,"d":"1.76E-09"},{"v":2.18662695610995e-07,"d":"2.19E-07"},"up","yes","METTL11B","protein_coding","chrNC_037343.1:37760115-37779595:+","gi|528979770|ref|XP_005216959.1|",1462,0,"PREDICTED: alpha N-terminal protein methyltransferase 1B isoform X1 [Bos taurus]","gi|982947813|ref|XM_005216902.3|",2307,0,"PREDICTED: Bos taurus methyltransferase like 11B (METTL11B), transcript variant X1, mRNA","Q5VVY1",455,{"v":2e-153,"d":"2.00E-153"},"Alpha N-terminal protein methyltransferase 1B",".",".",".",".","pfam05891","Methyltransf_PK","AdoMet dependent proline di-methyltransferase. This protein is expressed in the tail neuron PVT and in uterine cells in C. elegans [worm-base]. In Saccharomyces cerevisiae this is AdoMet dependent proline di-methyltransferase. This enzyme catalyses the di-methylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues. The methyltransferases described here specifically recognize the N-terminal X-Pro-Lys sequence motif, and they may account for nearly all previously described eukaryotic protein N-terminal methylation reactions. A number of other yeast and human proteins also share the recognition motif and may be similarly modified. As with other methyltransferases, this family carries the characteristic GxGxG motif.","GO:0006480|N-terminal protein amino acid methylation;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0071885|N-terminal protein N-methyltransferase activity;","K19579","NTM1B, METTL11B; protein N-terminal monomethyltransferase [EC:2.1.1.299]"]
["gene20285",1510,4475,3320,2879.72152565107,816,711,912,895.130197411717,3.21709795287638,1.68575986324511,{"v":3.99424018535268e-11,"d":"3.99E-11"},{"v":7.12247917051859e-09,"d":"7.12E-09"},"up","yes","DHRS3","protein_coding","chrNC_037343.1:41110124-41160247:+","gi|386782143|ref|NP_001247466.1|",1612,0,"short-chain dehydrogenase/reductase 3 [Macaca mulatta]","gi|942036662|ref|XM_005889199.2|",2257,0,"PREDICTED: Bos mutus dehydrogenase/reductase (SDR family) member 3 (DHRS3), transcript variant X1, mRNA","O75911",624,0,"Short-chain dehydrogenase/reductase 3",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0060349|bone morphogenesis;GO:0060411|cardiac septum morphogenesis;GO:0048387|negative regulation of retinoic acid receptor signaling pathway;GO:0003151|outflow tract morphogenesis;GO:0030278|regulation of ossification;GO:0001523|retinoid metabolic process;GO:0042572|retinol metabolic process;GO:0060021|palate development;GO:0007601|visual perception;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0042622|photoreceptor outer segment membrane;","GO:0009055|electron carrier activity;GO:0052650|NADP-retinol dehydrogenase activity;GO:0000166|nucleotide binding;GO:0004745|retinol dehydrogenase activity;","K11146","DHRS3; short-chain dehydrogenase/reductase 3 [EC:1.1.1.300]"]
["gene20297",1753,4569,4876,3451.7396959419,648,877,887,884.232772501573,3.90365501402602,1.96482556018928,{"v":9.30929506737701e-15,"d":"9.31E-15"},{"v":3.08841276241085e-12,"d":"3.09E-12"},"up","yes","KIAA2013","protein_coding","chrNC_037343.1:41753807-41759436:+","gi|114052028|ref|NP_001039407.1|",2849,0,"uncharacterized protein KIAA2013 homolog precursor [Bos taurus]","gi|402745105|ref|NM_001045942.2|",2226,0,"Bos taurus KIAA2013 ortholog (KIAA2013), mRNA","Q2KHV9",1102,0,"Uncharacterized protein KIAA2013 homolog",".",".",".",".","pfam10222","DUF2152","Uncharacterized conserved protein (DUF2152). This is a family of proteins conserved from worms to humans. Its function is unknown.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene20336",253,163,241,193.371974329788,88,71,74,85.6597030800602,2.25744390158645,1.17469013658381,0.000992948353729234,0.0179968119104313,"up","yes","CTNNBIP1","protein_coding","chrNC_037343.1:43628070-43675451:+","gi|511898169|ref|XP_004768659.1|",447,{"v":1e-50,"d":"1.00E-50"},"PREDICTED: beta-catenin-interacting protein 1 isoform X1 [Mustela putorius furo]","gi|741954303|ref|XM_005216982.2|",995,0,"PREDICTED: Bos taurus catenin beta interacting protein 1 (CTNNBIP1), transcript variant X1, mRNA","Q5E9N2",167,{"v":7e-49,"d":"7.00E-49"},"Beta-catenin-interacting protein 1",".",".",".",".","pfam06384","ICAT","Beta-catenin-interacting protein ICAT. This family consists of several eukaryotic beta-catenin-interacting (ICAT) proteins. Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various cancers. ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions.","GO:0009952|anterior/posterior pattern specification;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0043392|negative regulation of DNA binding;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0072201|negative regulation of mesenchymal cell proliferation;GO:0032091|negative regulation of protein binding;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0060633|negative regulation of transcription initiation from RNA polymerase II promoter;GO:0030178|negative regulation of Wnt signaling pathway;GO:0045657|positive regulation of monocyte differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0002528|regulation of vascular permeability involved in acute inflammatory response;GO:0016055|Wnt signaling pathway;","GO:0030877|beta-catenin destruction complex;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0070016|armadillo repeat domain binding;GO:0008013|beta-catenin binding;","K04493","ICAT, CTNNBIP1; Beta-catenin-interacting protein 1 (Inhibitor of beta-catenin and Tcf-4)"]
["gene20343",746,865,984,780.108414663888,250,398,306,349.960778870712,2.22913098199523,1.15648139072197,0.000215083864624057,0.00533240697670016,"up","yes","TMEM201","protein_coding","chrNC_037343.1:43890081-43911997:-","gi|82697323|ref|NP_001032528.1|",1660,0,"transmembrane protein 201 [Bos taurus]","gi|82697322|ref|NM_001037451.1|",4260,0,"Bos taurus transmembrane protein 201 (TMEM201), mRNA","Q32PF0",644,0,"Transmembrane protein 201",".",".",".",".","pfam10476","DUF2448","Protein of unknown function C-terminus (DUF2448). The family DUF2349 is the N-terminal part of this family. This protein is found in eukaryotes but its function is not known.",".","GO:0005737|cytoplasm;GO:0005639|integral component of nuclear inner membrane;GO:0000922|spindle pole;",".",".","."]
["gene20367",611,970,1504,939.037883483904,481,335,438,460.829412132913,2.03771256512825,1.02695056273551,0.000150350178758348,0.00409316884556721,"up","yes","ERRFI1","protein_coding","chrNC_037343.1:45352249-45366512:+","gi|555961319|ref|XP_005892756.1|",2229,0,"PREDICTED: ERBB receptor feedback inhibitor 1 [Bos mutus]","gi|118150959|ref|NM_001077930.1|",3055,0,"Bos taurus ERBB receptor feedback inhibitor 1 (ERRFI1), mRNA","Q9UJM3",661,0,"ERBB receptor feedback inhibitor 1",".",".",".",".","pfam11555","Inhibitor_Mig-6","EGFR receptor inhibitor Mig-6. When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive.","GO:0071474|cellular hyperosmotic response;GO:0071549|cellular response to dexamethasone stimulus;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0032869|cellular response to insulin stimulus;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0048286|lung alveolus development;GO:0060428|lung epithelium development;GO:0060426|lung vasculature development;GO:1903243|negative regulation of cardiac muscle hypertrophy in response to stress;GO:0032966|negative regulation of collagen biosynthetic process;GO:0007175|negative regulation of epidermal growth factor-activated receptor activity;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0032691|negative regulation of interleukin-1 beta production;GO:0031953|negative regulation of protein autophosphorylation;GO:0042536|negative regulation of tumor necrosis factor biosynthetic process;GO:0045616|regulation of keratinocyte differentiation;GO:0061469|regulation of type B pancreatic cell proliferation;GO:0043589|skin morphogenesis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0005634|nucleus;","GO:0005096|GTPase activator activity;GO:0019901|protein kinase binding;GO:0017124|SH3 domain binding;GO:0031267|small GTPase binding;",".","."]
["gene20394",557,1519,1310,1045.2996376592,320,344,349,371.829050661713,2.81123714190423,1.49120515738916,{"v":2.79144703785831e-08,"d":"2.79E-08"},{"v":2.70893794003862e-06,"d":"2.71E-06"},"up","yes","ICMT","protein_coding","chrNC_037343.1:47112197-47121801:+","gi|817316823|ref|XP_012329079.1|",1251,{"v":1e-157,"d":"1.00E-157"},"PREDICTED: protein-S-isoprenylcysteine O-methyltransferase [Aotus nancymaae]","gi|742165531|ref|XM_010850202.1|",3737,0,"PREDICTED: Bison bison bison isoprenylcysteine carboxyl methyltransferase (ICMT), mRNA","O60725",469,{"v":8e-153,"d":"8.00E-153"},"Protein-S-isoprenylcysteine O-methyltransferase","YDR410c",171,{"v":4e-46,"d":"4.00E-46"},"COG2020","pfam04140","ICMT","Isoprenylcysteine carboxyl methyltransferase (ICMT) family. The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.","GO:0006481|C-terminal protein methylation;GO:0006464|cellular protein modification process;GO:0043687|post-translational protein modification;GO:0006612|protein targeting to membrane;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016020|membrane;","GO:0003880|protein C-terminal carboxyl O-methyltransferase activity;GO:0004671|protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity;","K00587","ICMT, STE14; protein-S-isoprenylcysteine O-methyltransferase [EC:2.1.1.100]"]
["gene20421",0,30,0,9.83153037619775,1,0,0,0.373768090184884,26.3038248431924,4.71720069216516,0.00310206439166224,0.0423266375698304,"up","yes","ACTRT2","protein_coding","chrNC_037343.1:50032369-50033784:-","gi|84000199|ref|NP_001033204.1|",1928,0,"actin-related protein T2 [Bos taurus]","gi|84000198|ref|NM_001038115.1|",1407,0,"Bos taurus actin related protein T2 (ACTRT2), mRNA","Q2TA43",747,0,"Actin-related protein T2","SPBC32H8.12c",392,{"v":4e-132,"d":"4.00E-132"},"COG5277","pfam00022","Actin","Actin.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;",".",".","."]
["gene20462",676,246,315,353.543171772653,127,99,114,124.951226067105,2.829449401183,1.50052133805151,{"v":1.35326570682263e-06,"d":"1.35E-06"},{"v":7.92813632060705e-05,"d":"7.93E-05"},"up","yes","VWA1","protein_coding","chrNC_037343.1:51109184-51114414:-","gi|594086974|ref|XP_006066977.1|",1960,0,"PREDICTED: von Willebrand factor A domain-containing protein 1 isoform X2 [Bubalus bubalis]","gi|157073981|ref|NM_001103230.1|",2388,0,"Bos taurus von Willebrand factor A domain containing 1 (VWA1), mRNA","A6QLN9",721,0,"von Willebrand factor A domain-containing protein 1",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0048266|behavioral response to pain;GO:0030198|extracellular matrix organization;GO:0006412|translation;","GO:0005604|basement membrane;GO:0005614|interstitial matrix;GO:0005840|ribosome;","GO:0042802|identical protein binding;GO:0003735|structural constituent of ribosome;",".","."]
["gene2047",110,725,493,417.674838845556,51,125,69,89.8427480263833,4.64895440111539,2.21690627537132,0.00052494789301628,0.0109483101868768,"up","yes","BOLL","protein_coding","chrNC_037329.1:86226318-86295179:-","gi|795075574|ref|XP_011844543.1|",1278,{"v":1e-169,"d":"1.00E-169"},"PREDICTED: protein boule-like isoform X1 [Mandrillus leucophaeus]","gi|555965204|ref|XM_005894599.1|",1784,0,"PREDICTED: Bos mutus boule-like RNA-binding protein (BOLL), transcript variant X1, mRNA","Q8WP23",446,{"v":4e-152,"d":"4.00E-152"},"Protein boule-like","TP0356",56.6,{"v":1e-08,"d":"1.00E-08"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0007281|germ cell development;GO:0007275|multicellular organismal development;GO:0006417|regulation of translation;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;","GO:0003729|mRNA binding;",".","."]
["gene20505",1287,1729,1490,1359.65720723247,620,457,571,605.565054249605,2.24527026071098,1.16688911103341,{"v":4.03193328201098e-06,"d":"4.03E-06"},0.000195173244947077,"up","yes","FBLIM1","protein_coding","chrNC_037343.1:51777671-51805367:-","gi|528980307|ref|XP_005217192.1|",1548,0,"PREDICTED: filamin-binding LIM protein 1 isoform X1 [Bos taurus]","gi|982948209|ref|XM_005217136.3|",2829,0,"PREDICTED: Bos taurus filamin binding LIM protein 1 (FBLIM1), transcript variant X3, mRNA","Q1JQB5",549,0,"Filamin-binding LIM protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0098609|cell-cell adhesion;GO:0008360|regulation of cell shape;GO:0033623|regulation of integrin activation;","GO:0005938|cell cortex;GO:0001650|fibrillar center;GO:0005925|focal adhesion;GO:0001725|stress fiber;","GO:0031005|filamin binding;GO:0046872|metal ion binding;",".","."]
["gene20522",270,279,420,290.792592559819,27,63,67,57.397138807694,5.06632557999282,2.34093979271327,{"v":6.04018009716366e-06,"d":"6.04E-06"},0.00027706170153083,"up","yes","TMEM51","protein_coding","chrNC_037343.1:52283709-52343006:-","gi|149642845|ref|NP_001092445.1|",1011,{"v":5e-130,"d":"5.00E-130"},"transmembrane protein 51 [Bos taurus]","gi|982948124|ref|XM_005217083.3|",1950,0,"PREDICTED: Bos taurus transmembrane protein 51 (TMEM51), transcript variant X1, mRNA","Q9NW97",344,{"v":4e-112,"d":"4.00E-112"},"Transmembrane protein 51",".",".",".",".","pfam15345","TMEM51","Transmembrane protein 51. This family of proteins is found in eukaryotes. Proteins in this family are typically between 233 and 253 amino acids in length.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene20528",196,296,1016,460.12216721088,160,191,145,182.238588932285,2.52483389992582,1.33618848107813,{"v":1.57709184671135e-05,"d":"1.58E-05"},0.000624944548312798,"up","yes","PDPN","protein_coding","chrNC_037343.1:54010801-54043029:-","gi|296478978|tpg|DAA21093.1|",618,{"v":6e-79,"d":"6.00E-79"},"TPA: podoplanin [Bos taurus]","gi|151553839|gb|BC149398.1|",501,0,"Bos taurus podoplanin, mRNA (cDNA clone MGC:148958 IMAGE:8266027), complete cds","Q86YL7",74.3,{"v":2e-15,"d":"2.00E-15"},"Podoplanin",".",".",".",".","pfam05808","Podoplanin","Podoplanin. This family consists of several mammalian podoplanin like proteins which are thought to control specifically the unique shape of podocytes.","GO:0070252|actin-mediated cell contraction;GO:0000902|cell morphogenesis;GO:0030324|lung development;GO:0048535|lymph node development;GO:0001946|lymphangiogenesis;GO:0060838|lymphatic endothelial cell fate commitment;GO:0043066|negative regulation of apoptotic process;GO:0008285|negative regulation of cell proliferation;GO:0030168|platelet activation;GO:0030335|positive regulation of cell migration;GO:0051272|positive regulation of cellular component movement;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0090091|positive regulation of extracellular matrix disassembly;GO:1901731|positive regulation of platelet aggregation;GO:0008360|regulation of cell shape;GO:2000392|regulation of lamellipodium morphogenesis;GO:1904328|regulation of myofibroblast contraction;GO:1900024|regulation of substrate adhesion-dependent cell spreading;GO:0007266|Rho protein signal transduction;GO:0044319|wound healing, spreading of cells;","GO:0016324|apical plasma membrane;GO:0016323|basolateral plasma membrane;GO:0030054|cell junction;GO:0042995|cell projection;GO:0031410|cytoplasmic vesicle;GO:0005829|cytosol;GO:0030175|filopodium;GO:0031527|filopodium membrane;GO:0005887|integral component of plasma membrane;GO:0071437|invadopodium;GO:0030027|lamellipodium;GO:0031258|lamellipodium membrane;GO:0016020|membrane;GO:0045121|membrane raft;GO:0031528|microvillus membrane;GO:0005886|plasma membrane;GO:0001726|ruffle;GO:0032587|ruffle membrane;GO:0097197|tetraspanin-enriched microdomain;","GO:0051087|chaperone binding;GO:0019956|chemokine binding;GO:0005102|receptor binding;","K16778","PDPN; podoplanin"]
["gene20529",14,5,18,10.8155031166858,0,0,1,0.360972888453242,29.9620926187279,4.90506648321111,0.00134805042323155,0.0228935872769163,"up","yes","LRRC38","protein_coding","chrNC_037343.1:54111496-54147187:+","gi|297484268|ref|XP_002694193.1|",1273,{"v":1e-165,"d":"1.00E-165"},"PREDICTED: leucine-rich repeat-containing protein 38 isoform X1 [Bos taurus]","gi|982948565|ref|XM_002694147.4|",2644,0,"PREDICTED: Bos taurus leucine rich repeat containing 38 (LRRC38), transcript variant X1, mRNA","A2VDH3",470,{"v":1e-157,"d":"1.00E-157"},"Leucine-rich repeat-containing protein 38","SPy1798",55.1,{"v":9e-07,"d":"9.00E-07"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007409|axonogenesis;GO:1903818|positive regulation of voltage-gated potassium channel activity;GO:0071805|potassium ion transmembrane transport;","GO:0005615|extracellular space;GO:0008076|voltage-gated potassium channel complex;","GO:0044325|ion channel binding;GO:0005249|voltage-gated potassium channel activity;",".","."]
["gene20583",1943,313,515,767.134224072595,276,280,307,316.735188963218,2.42200504018415,1.27620186727878,{"v":6.27693288168645e-06,"d":"6.28E-06"},0.000286998673152878,"up","yes","KIAA0040","protein_coding","chrNC_037343.1:56397327-56436473:-","gi|528759349|gb|EPY79008.1|",416,{"v":2e-41,"d":"2.00E-41"},"hypothetical protein CB1_000976005 [Camelus ferus]","gi|982997002|ref|XM_005194884.3|",3743,0,"PREDICTED: Bos taurus KIAA0040 ortholog (KIAA0040), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15196","Harakiri","Activator of apoptosis harakiri.",".",".",".",".","."]
["gene20594",20,22,372,126.671501381483,11,8,13,11.7399970938414,10.7897387340864,3.43158802629333,{"v":3.04852421490915e-12,"d":"3.05E-12"},{"v":6.95819555004584e-10,"d":"6.96E-10"},"up","yes","PAPPA2","protein_coding","chrNC_037343.1:57723375-58039310:+","gi|741955007|ref|XP_010811788.1|",9021,0,"PREDICTED: pappalysin-2 [Bos taurus]","gi|982997007|ref|XM_015466918.1|",9616,0,"PREDICTED: Bos taurus pappalysin 2 (PAPPA2), mRNA","Q9BXP8",2850,0,"Pappalysin-2",".",".",".",".","pfam13385","Laminin_G_3","Concanavalin A-like lectin/glucanases superfamily. This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.","GO:0060349|bone morphogenesis;GO:0044267|cellular protein metabolic process;GO:0006508|proteolysis;GO:0001558|regulation of cell growth;GO:0009651|response to salt stress;","GO:0016324|apical plasma membrane;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005622|intracellular;","GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K08647","PAPPA2; pappalysin-2 [EC:3.4.24.-]"]
["gene20677",1991,575,843,966.242067216317,429,371,411,444.858755938681,2.17201989242064,1.11903731610967,{"v":3.10039421354694e-05,"d":"3.10E-05"},0.0010903261504338,"up","yes","COLGALT2","protein_coding","chrNC_037343.1:64972407-65091021:-","gi|555962125|ref|XP_005893156.1|",3042,0,"PREDICTED: procollagen galactosyltransferase 2 [Bos mutus]","gi|300796727|ref|NM_001191302.1|",1878,0,"Bos taurus collagen beta(1-O)galactosyltransferase 2 (COLGALT2), mRNA","Q8IYK4",1124,0,"Procollagen galactosyltransferase 2",".",".",".",".","pfam01755","Glyco_transf_25","Glycosyltransferase family 25 (LPS biosynthesis protein). Members of this family belong to Glycosyltransferase family 25 This is a family of glycosyltransferases involved in lipopolysaccharide (LPS) biosynthesis. These enzymes catalyse the transfer of various sugars onto the growing LPS chain during its biosynthesis.",".","GO:0005788|endoplasmic reticulum lumen;","GO:0050211|procollagen galactosyltransferase activity;","K11703","GLT25D; collagen beta-1,O-galactosyltransferase [EC:2.4.1.50]"]
["gene20690",22915,6529,8623,10760.1600462443,3432,5732,4202,4903.15290824254,2.19453895230469,1.13391787776104,0.00180372284419516,0.0285741346295014,"up","yes","IVNS1ABP","protein_coding","chrNC_037343.1:66278361-66299685:-","gi|328927094|ref|NP_001039649.2|",3430,0,"influenza virus NS1A-binding protein [Bos taurus]","gi|982949005|ref|XM_005217348.3|",3702,0,"PREDICTED: Bos taurus influenza virus NS1A binding protein (IVNS1ABP), transcript variant X1, mRNA","Q920Q8",1291,0,"Influenza virus NS1A-binding protein homolog",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:2001243|negative regulation of intrinsic apoptotic signaling pathway;GO:0031397|negative regulation of protein ubiquitination;GO:0009615|response to virus;GO:0008380|RNA splicing;","GO:0015629|actin cytoskeleton;GO:0005829|cytosol;GO:0005634|nucleus;",".","K15046","NS1BP; influenza virus NS1A-binding protein"]
["gene2071",6860,1744,2324,3073.16571373794,1173,1568,1313,1487.82388050142,2.06554401634031,1.04652180407168,{"v":6.05160583683383e-05,"d":"6.05E-05"},0.00191805939973421,"up","yes","CLK1","protein_coding","chrNC_037329.1:89504940-89513097:-","gi|528939774|ref|XP_005202724.1|",2388,0,"PREDICTED: dual specificity protein kinase CLK1 isoform X1 [Bos taurus]","gi|742206774|ref|XM_010860945.1|",1826,0,"PREDICTED: Bison bison bison CDC-like kinase 1 (CLK1), transcript variant X1, mRNA","P49759",864,0,"Dual specificity protein kinase CLK1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0008283|cell proliferation;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0046777|protein autophosphorylation;GO:0043484|regulation of RNA splicing;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;","K08823","CLK; CDC-like kinase [EC:2.7.12.1]"]
["gene20737",2342,2195,7339,3583.68559557873,1802,1201,1661,1713.85813659032,2.09100480317956,1.06419637589945,0.000505049071528667,0.0106343579777007,"up","yes","ATF3","protein_coding","chrNC_037343.1:70924499-70937427:-","gi|594100093|ref|XP_006073154.1|",762,{"v":1e-92,"d":"1.00E-92"},"PREDICTED: cyclic AMP-dependent transcription factor ATF-3 isoform X4 [Bubalus bubalis]","gi|982949014|ref|XM_010813555.2|",2284,0,"PREDICTED: Bos taurus activating transcription factor 3 (ATF3), transcript variant X1, mRNA","Q2KII1",295,{"v":3e-93,"d":"3.00E-93"},"Cyclic AMP-dependent transcription factor ATF-3",".",".",".",".","pfam00170","bZIP_1","bZIP transcription factor. The Pfam entry includes the basic region and the leucine zipper region.","GO:0034198|cellular response to amino acid starvation;GO:0030968|endoplasmic reticulum unfolded protein response;GO:0006094|gluconeogenesis;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:1903984|positive regulation of TRAIL-activated apoptotic signaling pathway;GO:1990440|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:0035914|skeletal muscle cell differentiation;GO:0006351|transcription, DNA-templated;","GO:1990622|CHOP-ATF3 complex;GO:0005730|nucleolus;","GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09032","ATF3, LRF1; activating transcription factor 3"]
["gene2077",772,312,496,455.78138501963,126,212,210,200.700450564238,2.27095347189441,1.18329814789648,0.000505023234788804,0.0106343579777007,"up","yes","NDUFB3","protein_coding","chrNC_037329.1:89662180-89672936:+","gi|528939641|ref|XP_005202658.1|",705,{"v":7e-92,"d":"7.00E-92"},"PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [Bos taurus]","gi|528939640|ref|XM_005202601.1|",641,0,"PREDICTED: Bos taurus NADH:ubiquinone oxidoreductase subunit B3 (NDUFB3), transcript variant X1, mRNA","Q02365",208,{"v":3e-67,"d":"3.00E-67"},"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3",".",".",".",".","pfam08122","NDUF_B12","NADH-ubiquinone oxidoreductase B12 subunit family. This family consists of the NADH-ubiquinone oxidoreductase B12 subunit proteins. NADH is the central source of electrons in the mitochondrial and bacterial respiration. NADH-ubiquinone oxidoreductase is involved in the transfer of electrons from NADH to the electron transport chain. This oxidation of NADH is coupled to proton transfer across the membrane, generating a proton motive force that is utilized for the synthesis of ATP. The function of this subunit is unclear.","GO:0022900|electron transport chain;GO:0032981|mitochondrial respiratory chain complex I assembly;","GO:0016021|integral component of membrane;GO:0005747|mitochondrial respiratory chain complex I;",".","K03959","NDUFB3; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3"]
["gene20819",2797,3829,3429,3036.9142687551,1388,1132,1272,1393.37755138519,2.17953437367785,1.1240199567745,{"v":6.39743298424186e-06,"d":"6.40E-06"},0.000291573738775407,"up","yes","NEK7","protein_coding","chrNC_037343.1:77074380-77212569:+","gi|664738798|ref|XP_008526690.1|",1659,0,"PREDICTED: serine/threonine-protein kinase Nek7 isoform X1 [Equus przewalskii]","gi|982997375|ref|XM_003583276.4|",3953,0,"PREDICTED: Bos taurus NIMA related kinase 7 (NEK7), transcript variant X1, mRNA","Q8TDX7",629,0,"Serine/threonine-protein kinase Nek7",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0051973|positive regulation of telomerase activity;GO:1904355|positive regulation of telomere capping;GO:0032212|positive regulation of telomere maintenance via telomerase;GO:0006468|protein phosphorylation;GO:0007346|regulation of mitotic cell cycle;GO:0051225|spindle assembly;","GO:0005737|cytoplasm;GO:0005874|microtubule;GO:0005815|microtubule organizing center;GO:0005654|nucleoplasm;GO:0000922|spindle pole;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004674|protein serine/threonine kinase activity;",".","."]
["gene20838",171,34,44,69.2223264707728,23,13,25,22.3918266824462,3.09141042633376,1.62826520409218,0.0017458562566584,0.0279209780598211,"up","yes","NR5A2","protein_coding","chrNC_037343.1:78828934-78957232:+","gi|594111329|ref|XP_006078489.1|",2589,0,"PREDICTED: nuclear receptor subfamily 5 group A member 2 isoform X3 [Bubalus bubalis]","gi|982949108|ref|XM_010813581.2|",4398,0,"PREDICTED: Bos taurus nuclear receptor subfamily 5 group A member 2 (NR5A2), transcript variant X1, mRNA","O00482",962,0,"Nuclear receptor subfamily 5 group A member 2",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0008206|bile acid metabolic process;GO:1990830|cellular response to leukemia inhibitory factor;GO:0042632|cholesterol homeostasis;GO:0009792|embryo development ending in birth or egg hatching;GO:0030855|epithelial cell differentiation;GO:0042592|homeostatic process;GO:0009755|hormone-mediated signaling pathway;GO:0061113|pancreas morphogenesis;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045070|positive regulation of viral genome replication;GO:0042127|regulation of cell proliferation;GO:0006355|regulation of transcription, DNA-templated;GO:0009888|tissue development;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0090575|RNA polymerase II transcription factor complex;","GO:0003682|chromatin binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0004879|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0005543|phospholipid binding;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0003707|steroid hormone receptor activity;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0044212|transcription regulatory region DNA binding;GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0008270|zinc ion binding;","K08027","NR5A2, FTF; nuclear receptor subfamily 5 group A member 2"]
["gene20839",1817,4182,2510,2614.9430561297,1079,975,972,1111.97429665075,2.35162185313623,1.23365608973817,{"v":1.70532352125495e-06,"d":"1.71E-06"},{"v":9.6728797981958e-05,"d":"9.67E-05"},"up","yes","ZNF281","protein_coding","chrNC_037343.1:79114447-79121308:-","gi|803273227|ref|XP_011996307.1|",3713,0,"PREDICTED: zinc finger protein 281 isoform X2 [Ovis aries musimon]","gi|982997391|ref|XM_610917.8|",4506,0,"PREDICTED: Bos taurus zinc finger protein 281 (ZNF281), mRNA","Q9Y2X9",1334,0,"Zinc finger protein 281",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0010172|embryonic body morphogenesis;GO:0010629|negative regulation of gene expression;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045893|positive regulation of transcription, DNA-templated;GO:0048863|stem cell differentiation;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0001047|core promoter binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0003714|transcription corepressor activity;GO:0044212|transcription regulatory region DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;",".","."]
["gene20855",16594,63657,38207,36920.5025525788,14388,16387,15622,17030.7190380267,2.16787690937426,1.11628284374126,0.00183971375715975,0.0289354317560777,"up","yes","CACNA1S","protein_coding","chrNC_037343.1:79601782-79658546:-","gi|594111369|ref|XP_006078505.1|",8853,0,"PREDICTED: voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [Bubalus bubalis]","gi|594111368|ref|XM_006078443.1|",5664,0,"PREDICTED: Bubalus bubalis calcium channel, voltage-dependent, L type, alpha 1S subunit (CACNA1S), transcript variant X1, mRNA","Q13698",3173,0,"Voltage-dependent L-type calcium channel subunit alpha-1S",".",".",".",".","pfam00520","Ion_trans","Ion transport protein. This family contains Sodium, Potassium, Calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. A bacterial structure of the protein is known for the last two helices but is not the Pfam family due to it lacking the first four helices","GO:0006816|calcium ion transport;GO:0071313|cellular response to caffeine;GO:0086010|membrane depolarization during action potential;GO:0006936|muscle contraction;GO:0034765|regulation of ion transmembrane transport;","GO:0005737|cytoplasm;GO:0031674|I band;GO:1990454|L-type voltage-gated calcium channel complex;GO:0005886|plasma membrane;GO:0030315|T-tubule;GO:0005891|voltage-gated calcium channel complex;","GO:0005516|calmodulin binding;GO:0008331|high voltage-gated calcium channel activity;GO:0046872|metal ion binding;GO:0005245|voltage-gated calcium channel activity;","K04857","CACNA1S; voltage-dependent calcium channel L type alpha-1S"]
["gene20859",13030,21933,1037,10902.2377680656,3776,5603,5101,5308.90236158596,2.05357662008474,1.03813877607475,0.000381282808132119,0.00849209976488484,"up","yes","IGFN1","protein_coding","chrNC_037343.1:79716615-79747014:+","gi|942095984|ref|XP_014338253.1|",6116,0,"PREDICTED: immunoglobulin-like and fibronectin type III domain-containing protein 1 [Bos mutus]","gi|594111430|ref|XM_006078471.1|",4784,0,"PREDICTED: Bubalus bubalis immunoglobulin-like and fibronectin type III domain containing 1 (IGFN1), mRNA","Q86VF2",1197,0,"Immunoglobulin-like and fibronectin type III domain-containing protein 1",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".","GO:0005634|nucleus;GO:0030018|Z disc;",".",".","."]
["gene20888",2336,6959,2787,3745.35120371384,434,1061,752,823.040773954878,4.55062655731704,2.18606519781726,0.000127551347975613,0.00355992675802721,"up","yes","LMOD1","protein_coding","chrNC_037343.1:80548456-80575804:+","gi|139948705|ref|NP_001077184.1|",2183,0,"leiomodin-1 [Bos taurus]","gi|139948704|ref|NM_001083715.1|",2494,0,"Bos taurus leiomodin 1 (LMOD1), mRNA","P29536",545,0,"Leiomodin-1",".",".",".",".","pfam10243","MIP-T3","Microtubule-binding protein MIP-T3. This protein, which interacts with both microtubules and TRAF3 (tumor necrosis factor receptor-associated factor 3), is conserved from worms to humans. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved.","GO:0045010|actin nucleation;GO:0006936|muscle contraction;GO:0030239|myofibril assembly;GO:0051694|pointed-end actin filament capping;GO:0030838|positive regulation of actin filament polymerization;","GO:0005884|actin filament;GO:0005829|cytosol;GO:0016020|membrane;GO:0030016|myofibril;GO:0030017|sarcomere;GO:0005865|striated muscle thin filament;","GO:0003779|actin binding;GO:0005523|tropomyosin binding;",".","."]
["gene20891",195,384,120,213.519716031365,42,59,38,51.0674961193655,4.18112757148466,2.06389206250199,{"v":3.79396988716452e-08,"d":"3.79E-08"},{"v":3.56071562008852e-06,"d":"3.56E-06"},"up","yes","LOC112441884","protein_coding","chrNC_037343.1:80582026-80589869:+","gi|556718771|ref|XP_005955277.1|",280,{"v":2e-21,"d":"2.00E-21"},"PREDICTED: importin-9 [Pantholops hodgsonii]","gi|114155007|gb|AY563794.1|",625,0,"Bos taurus clone NG010006B21G04 mRNA, complete sequence","O00370",72.8,{"v":8e-20,"d":"8.00E-20"},"LINE-1 retrotransposable element ORF2 protein",".",".",".",".","pfam11445","DUF2894","Protein of unknown function (DUF2894). This is a bacterial family of uncharacterized proteins.","GO:0006310|DNA recombination;GO:0090305|nucleic acid phosphodiester bond hydrolysis;GO:0032199|reverse transcription involved in RNA-mediated transposition;GO:0032197|transposition, RNA-mediated;",".","GO:0046872|metal ion binding;GO:0003964|RNA-directed DNA polymerase activity;GO:0009036|Type II site-specific deoxyribonuclease activity;",".","."]
["gene20902",230,92,76,113.434615113551,35,33,47,42.158198690425,2.6906893234818,1.42797582191583,0.000737701940942093,0.014337448281348,"up","yes","TNNT2","protein_coding","chrNC_037343.1:80931617-80943043:+","gi|27807485|ref|NP_777196.1|",876,{"v":9e-113,"d":"9.00E-113"},"troponin T, cardiac muscle [Bos taurus]","gi|136256404|ref|NM_174771.3|",1103,0,"Bos taurus troponin T type 2 (cardiac) (TNNT2), mRNA","P13789",331,{"v":4e-110,"d":"4.00E-110"},"Troponin T, cardiac muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0006937|regulation of muscle contraction;","GO:0005861|troponin complex;",".",".","."]
["gene20924",0,22,0,7.20978894254502,0,0,0,0,"Inf","Inf",0.00366327422936877,0.0478557129295423,"up","yes","RBM46","protein_coding","chrNC_037344.1:2540688-2599474:-","gi|859897168|ref|XP_012901085.1|",2527,0,"PREDICTED: probable RNA-binding protein 46 isoform X4 [Mustela putorius furo]","gi|982949496|ref|XM_010813650.2|",2605,0,"PREDICTED: Bos taurus RNA binding motif protein 46 (RBM46), transcript variant X3, mRNA","Q4R2Z0",961,0,"Probable RNA-binding protein 46",".",".",".",".","pfam14709","DND1_DSRM","double strand RNA binding domain from DEAD END PROTEIN 1. A C-terminal domain in human dead end protein 1 (DND1_HUMAN) homologous to double strand RNA binding domains (PF00035, PF00333)",".",".","GO:0003723|RNA binding;",".","."]
["gene20939",1956,1920,1625,1638.06964994145,635,886,702,815.896691086225,2.00769247851789,1.00553830629391,{"v":5.92843221438629e-05,"d":"5.93E-05"},0.00188776896773053,"up","yes","TMEM131L","protein_coding","chrNC_037344.1:3995808-4171105:-","gi|296478793|tpg|DAA20908.1|",6797,0,"TPA: transmembrane protein 131-like [Bos taurus]","gi|116003824|ref|NM_001076803.1|",4196,0,"Bos taurus KIAA0922 ortholog (KIAA0922), mRNA","Q08DV9",2593,0,"Transmembrane protein 131-like",".",".",".",".","pfam12371","DUF3651","Protein of unknown function (DUF3651). This domain family is found in eukaryotes, and is approximately 70 amino acids in length. This family is frequently annotated as a membrane protein but there is little associated literature to back this up.","GO:0090090|negative regulation of canonical Wnt signaling pathway;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".",".","."]
["gene21046",7,91,48,46.3885098788422,9,16,10,12.8454428000275,3.6112814950017,1.85251088099401,0.00294274667180203,0.0407570414044581,"up","yes","CLGN","protein_coding","chrNC_037344.1:17272256-17318723:+","gi|86559361|gb|ABD04088.1|",2991,0,"calmegin-like [Bos taurus]","gi|742230051|ref|XM_010830314.1|",3404,0,"PREDICTED: Bison bison bison calmegin (CLGN), mRNA","Q3SYT6",1150,0,"Calmegin",".",".",".",".","pfam00262","Calreticulin","Calreticulin family.","GO:0007339|binding of sperm to zona pellucida;GO:0065003|macromolecular complex assembly;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0005635|nuclear envelope;","GO:0005509|calcium ion binding;GO:0044183|protein binding involved in protein folding;GO:0051082|unfolded protein binding;","K09551","CLGN; calmegin"]
["gene21052",789,1006,1342,947.472951447675,369,462,393,449.331027313469,2.1086301498309,1.07630607104592,{"v":4.14965411214314e-05,"d":"4.15E-05"},0.0013798809029552,"up","yes","MGST2","protein_coding","chrNC_037344.1:18024427-18062298:-","gi|115496986|ref|NP_001069850.1|",616,{"v":4e-73,"d":"4.00E-73"},"microsomal glutathione S-transferase 2 precursor [Bos taurus]","gi|115496985|ref|NM_001076382.1|",1888,0,"Bos taurus microsomal glutathione S-transferase 2 (MGST2), mRNA","Q2KJG4",241,{"v":1e-74,"d":"1.00E-74"},"Microsomal glutathione S-transferase 2",".",".",".",".","pfam01124","MAPEG","MAPEG family. This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolizm). It includes proteins such as Prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.","GO:0006750|glutathione biosynthetic process;GO:0019370|leukotriene biosynthetic process;GO:0046466|membrane lipid catabolic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0005635|nuclear envelope;GO:0031090|organelle membrane;GO:0005886|plasma membrane;","GO:0008047|enzyme activator activity;GO:0004602|glutathione peroxidase activity;GO:0004364|glutathione transferase activity;GO:0004464|leukotriene-C4 synthase activity;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["gene21068",758,637,872,674.118639682712,307,226,289,302.007159041361,2.23212801253624,1.1584197680969,{"v":2.21618570208855e-05,"d":"2.22E-05"},0.000829789951001161,"up","yes","NOCT","protein_coding","chrNC_037344.1:18582254-18600421:-","gi|803240583|ref|XP_011980393.1|",2219,0,"PREDICTED: nocturnin isoform X2 [Ovis aries musimon]","gi|402691876|ref|NM_001082454.2|",2082,0,"Bos taurus nocturnin (NOCT), mRNA","Q9UK39",734,0,"Nocturnin","SPCC31H12.08c_2",114,{"v":2e-26,"d":"2.00E-26"},"COG5239","pfam03372","Exo_endo_phos","Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. This family includes: AP endonuclease proteins EC:4.2.99.18, DNase I proteins EC:3.1.21.1, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56, Sphingomyelinase EC:3.1.4.12 and Nocturnin.","GO:0032922|circadian regulation of gene expression;GO:0007623|circadian rhythm;GO:0033962|cytoplasmic mRNA processing body assembly;GO:0000290|deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:0006397|mRNA processing;GO:0048255|mRNA stabilization;GO:0010629|negative regulation of gene expression;GO:0045668|negative regulation of osteoblast differentiation;GO:0045600|positive regulation of fat cell differentiation;GO:0042752|regulation of circadian rhythm;GO:0045995|regulation of embryonic development;GO:0009991|response to extracellular stimulus;GO:0032496|response to lipopolysaccharide;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0000932|cytoplasmic mRNA processing body;GO:0048471|perinuclear region of cytoplasm;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0003729|mRNA binding;GO:0004535|poly(A)-specific ribonuclease activity;","K18764","CCRN4L; nocturnin [EC:3.1.13.4]"]
["gene21141",0,42,0,13.7641425266768,0,1,0,0.366987568989444,37.5057459427807,5.22903973071265,0.000337054778217248,0.00768751182051557,"up","yes","ADAD1","protein_coding","chrNC_037344.1:35221949-35307838:-","gi|803171550|ref|XP_011952925.1|",2876,0,"PREDICTED: adenosine deaminase domain-containing protein 1 isoform X2 [Ovis aries]","gi|965982594|ref|XM_012097535.2|",2043,0,"PREDICTED: Ovis aries adenosine deaminase domain containing 1 (ADAD1), transcript variant X2, mRNA","Q5SUE7",1035,0,"Adenosine deaminase domain-containing protein 1",".",".",".",".","pfam02137","A_deamin","Adenosine-deaminase (editase) domain. Adenosine deaminases acting on RNA (ADARs) can deaminate adenosine to form inosine. In long double-stranded RNA, this process is non-specific; it occurs site-specifically in RNA transcripts. The former is important in defence against viruses, whereas the latter may affect splicing or untranslated regions. They are primarily nuclear proteins, but a longer isoform of ADAR1 is found predominantly in the cytoplasm. ADARs are derived from the Tad1-like tRNA deaminases that are present across eukaryotes. These in turn belong to the nucleotide/nucleic acid deaminase superfamily and are characterized by a distinct insert between the two conserved cysteines that are involved in binding zinc.","GO:0007275|multicellular organismal development;GO:0006396|RNA processing;GO:0007286|spermatid development;","GO:0005634|nucleus;","GO:0004000|adenosine deaminase activity;GO:0003723|RNA binding;",".","."]
["gene21237",0,44,0,14.41957788509,1,0,0,0.373768090184884,38.5789431033488,5.26974171519393,0.000232374517452644,0.00566915041247017,"up","yes","PIWIL1","protein_coding","chrNC_037344.1:46727242-46765372:-","gi|548500601|ref|XP_005691395.1|",4424,0,"PREDICTED: piwi-like protein 1 [Capra hircus]","gi|942037783|ref|XM_005889573.2|",3355,0,"PREDICTED: Bos mutus piwi-like RNA-mediated gene silencing 1 (PIWIL1), mRNA","Q9JMB7",1674,0,"Piwi-like protein 1",".",".",".",".","pfam02171","Piwi","Piwi domain. This domain is found in the protein Piwi and its relatives. The function of this domain is the dsRNA guided hydrolysis of ssRNA. Determination of the crystal structure of Argonaute reveals that PIWI is an RNase H domain, and identifies Argonaute as Slicer, the enzyme that cleaves mRNA in the RNAi RISC complex. In addition, Mg+2 dependence and production of 3'-OH and 5' phosphate products are shared characteristics of RNaseH and RISC. The PIWI domain core has a tertiary structure belonging to the RNase H family of enzymes. RNase H fold proteins all have a five-stranded mixed beta-sheet surrounded by helices. By analogy to RNase H enzymes which cleave single-stranded RNA guided by the DNA strand in an RNA/DNA hybrid, the PIWI domain can be inferred to cleave single-stranded RNA, for example mRNA, guided by double stranded siRNA.","GO:0031047|gene silencing by RNA;GO:0051321|meiotic cell cycle;GO:0007275|multicellular organismal development;GO:0010529|negative regulation of transposition;GO:0034587|piRNA metabolic process;GO:0006417|regulation of translation;GO:0007286|spermatid development;GO:0007283|spermatogenesis;GO:0035093|spermatogenesis, exchange of chromosomal proteins;","GO:0033391|chromatoid body;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0097433|dense body;GO:0005634|nucleus;GO:0043186|P granule;","GO:0004521|endoribonuclease activity;GO:0046872|metal ion binding;GO:0003729|mRNA binding;GO:0034584|piRNA binding;GO:0019901|protein kinase binding;GO:0003727|single-stranded RNA binding;","K02156","AUB, PIWI; aubergine"]
["gene21319",5613,20017,13532,12178.7729590248,2235,2116,2330,2452.98420764093,4.9648802960445,2.31175893459457,{"v":4.15247010789084e-17,"d":"4.15E-17"},{"v":2.00803601098701e-14,"d":"2.01E-14"},"up","yes","MLXIP","protein_coding","chrNC_037344.1:53223799-53284518:-","gi|803210464|ref|XP_011965654.1|",4126,0,"PREDICTED: MLX-interacting protein isoform X2 [Ovis aries musimon]","gi|965789209|ref|XM_012110264.2|",5845,0,"PREDICTED: Ovis aries musimon MLX interacting protein (MLXIP), transcript variant X2, mRNA","Q2VPU4",1284,0,"MLX-interacting protein",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0006913|nucleocytoplasmic transport;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1900402|regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter;GO:0006357|regulation of transcription from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0005741|mitochondrial outer membrane;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046983|protein dimerization activity;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000989|transcription factor activity, transcription factor binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09113","MLX; MAX-like protein X"]
["gene21330",3635,3890,2986,3139.25243596706,684,707,725,776.822929090598,4.04114286333191,2.01476335488124,{"v":1.88941543511482e-16,"d":"1.89E-16"},{"v":8.04580772824791e-14,"d":"8.05E-14"},"up","yes","TMEM120B","protein_coding","chrNC_037344.1:53521523-53567544:-","gi|545868829|ref|XP_005670684.1|",1561,0,"PREDICTED: transmembrane protein 120B isoform X1 [Sus scrofa]","gi|982950207|ref|XM_005217774.3|",4505,0,"PREDICTED: Bos taurus transmembrane protein 120B (TMEM120B), transcript variant X2, mRNA","A6QPF8",579,0,"Transmembrane protein 120B",".",".",".",".","pfam07851","TMPIT","TMPIT-like protein. A number of members of this family are annotated as being transmembrane proteins induced by tumor necrosis factor alpha, but no literature was found to support this.","GO:0045444|fat cell differentiation;GO:0051291|protein heterooligomerization;","GO:0016021|integral component of membrane;GO:0005637|nuclear inner membrane;",".",".","."]
["gene21333",326,746,834,585.580006325879,137,272,229,233.68963857625,2.50580218230262,1.32527252723933,0.00217663337375898,0.0327516055352745,"up","yes","ORAI1","protein_coding","chrNC_037344.1:53610722-53650441:-","gi|594045482|ref|XP_006047218.1|",1350,{"v":2e-178,"d":"2.00E-178"},"PREDICTED: LOW QUALITY PROTEIN: calcium release-activated calcium channel protein 1 [Bubalus bubalis]","gi|742130504|ref|XM_010841342.1|",2291,0,"PREDICTED: Bison bison bison ORAI calcium release-activated calcium modulator 1 (ORAI1), mRNA","Q96D31",510,{"v":1e-174,"d":"1.00E-174"},"Calcium release-activated calcium channel protein 1",".",".",".",".","pfam07856","Orai-1","Mediator of CRAC channel activity. ORAI-1 is a protein homologue of Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 GFP reporters are co- expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1- related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins.","GO:0002250|adaptive immune response;GO:0070509|calcium ion import;GO:0061180|mammary gland epithelium development;GO:0051928|positive regulation of calcium ion transport;GO:0051924|regulation of calcium ion transport;GO:0002115|store-operated calcium entry;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0005516|calmodulin binding;GO:0042802|identical protein binding;GO:0015279|store-operated calcium channel activity;","K16056","ORAI1; calcium release-activated calcium channel protein 1"]
["gene21355",2391,2815,2627,2352.48395773042,836,739,788,868.120572978917,2.70985855070566,1.43821754769672,{"v":5.41253316570129e-09,"d":"5.41E-09"},{"v":6.00875423154178e-07,"d":"6.01E-07"},"up","yes","PPTC7","protein_coding","chrNC_037344.1:54411957-54453472:-","gi|507663213|ref|XP_004635970.1|",1504,0,"PREDICTED: protein phosphatase PTC7 homolog [Octodon degus]","gi|300797569|ref|NM_001192610.1|",924,0,"Bos taurus PTC7 protein phosphatase homolog (PPTC7), mRNA","Q8NI37",579,0,"Protein phosphatase PTC7 homolog","SPAC1556.03",120,{"v":2e-30,"d":"2.00E-30"},"COG0631","pfam07228","SpoIIE","Stage II sporulation protein E (SpoIIE). This family contains a number of bacterial stage II sporulation E proteins (EC:3.1.3.16). These are required for formation of a normal polar septum during sporulation. The N-terminal region is hydrophobic and is expected to contain up to 12 membrane-spanning segments.",".",".","GO:0046872|metal ion binding;GO:0004721|phosphoprotein phosphatase activity;",".","."]
["gene21377",959,2928,2654,2024.59586443873,847,818,809,908.804470578635,2.22775737794255,1.15559211925827,{"v":8.88691800368861e-06,"d":"8.89E-06"},0.00039128496537537,"up","yes","TMEM233","protein_coding","chrNC_037344.1:55759658-55830533:-","gi|548500893|ref|XP_005691510.1|",577,{"v":9e-67,"d":"9.00E-67"},"PREDICTED: transmembrane protein 233 isoform X1 [Capra hircus]","gi|982998257|ref|XM_002684418.5|",2414,0,"PREDICTED: Bos taurus transmembrane protein 233 (TMEM233), transcript variant X1, mRNA","B4DJY2",173,{"v":3e-49,"d":"3.00E-49"},"Transmembrane protein 233",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.","GO:0009607|response to biotic stimulus;","GO:0016021|integral component of membrane;GO:0016020|membrane;",".",".","."]
["gene21393",4633,5722,3035,4014.78217468287,374,1144,643,791.728611928505,5.07090701813036,2.34224382090187,0.00010880314778379,0.00309497767639013,"up","yes","NOS1","protein_coding","chrNC_037344.1:57691941-57887674:+","gi|742219379|ref|XP_010826842.1|",7675,0,"PREDICTED: nitric oxide synthase, brain isoform X1 [Bison bison bison]","gi|742219378|ref|XM_010828540.1|",9729,0,"PREDICTED: Bison bison bison nitric oxide synthase 1 (neuronal) (NOS1), transcript variant X1, mRNA","P29475",2751,0,"Nitric oxide synthase, brain","BH0823",348,{"v":4e-105,"d":"4.00E-105"},"COG4362","pfam02898","NO_synthase","Nitric oxide synthase, oxygenase domain.","GO:0006527|arginine catabolic process;GO:0045454|cell redox homeostasis;GO:0071363|cellular response to growth factor stimulus;GO:0042738|exogenous drug catabolic process;GO:0033555|multicellular organismal response to stress;GO:0007520|myoblast fusion;GO:0045776|negative regulation of blood pressure;GO:0051926|negative regulation of calcium ion transport;GO:0010523|negative regulation of calcium ion transport into cytosol;GO:0051346|negative regulation of hydrolase activity;GO:0043267|negative regulation of potassium ion transport;GO:0051612|negative regulation of serotonin uptake;GO:0042136|neurotransmitter biosynthetic process;GO:0006809|nitric oxide biosynthetic process;GO:0007263|nitric oxide mediated signal transduction;GO:0018119|peptidyl-cysteine S-nitrosylation;GO:0031284|positive regulation of guanylate cyclase activity;GO:0035066|positive regulation of histone acetylation;GO:1902307|positive regulation of sodium ion transmembrane transport;GO:0098735|positive regulation of the force of heart contraction;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:1902514|regulation of generation of L-type calcium current;GO:1903779|regulation of cardiac conduction;GO:0055117|regulation of cardiac muscle contraction;GO:0050767|regulation of neurogenesis;GO:0060314|regulation of ryanodine-sensitive calcium-release channel activity;GO:0002028|regulation of sodium ion transport;GO:0009408|response to heat;GO:0001666|response to hypoxia;GO:0006941|striated muscle contraction;GO:0042311|vasodilation;","GO:0005901|caveola;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0043197|dendritic spine;GO:0045121|membrane raft;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0048471|perinuclear region of cytoplasm;GO:0001917|photoreceptor inner segment;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;GO:0042383|sarcolemma;GO:0016529|sarcoplasmic reticulum;GO:0033017|sarcoplasmic reticulum membrane;GO:0045202|synapse;GO:0030315|T-tubule;GO:0030018|Z disc;","GO:0034618|arginine binding;GO:0046870|cadmium ion binding;GO:0005516|calmodulin binding;GO:0050660|flavin adenine dinucleotide binding;GO:0010181|FMN binding;GO:0020037|heme binding;GO:0044325|ion channel binding;GO:0050661|NADP binding;GO:0003958|NADPH-hemoprotein reductase activity;GO:0004517|nitric-oxide synthase activity;GO:0097110|scaffold protein binding;GO:0017080|sodium channel regulator activity;GO:0034617|tetrahydrobiopterin binding;","K13240","NOS1; nitric-oxide synthase, brain [EC:1.14.13.39]"]
["gene21427",67,39,204,92.895559613136,22,29,26,28.2508325845456,3.28824148226887,1.71731625172004,0.000375601308745887,0.00840921896053349,"up","yes","SDS","protein_coding","chrNC_037344.1:61030532-61038866:+","gi|555985865|ref|XP_005904801.1|",1518,0,"PREDICTED: L-serine dehydratase/L-threonine deaminase [Bos mutus]","gi|982950265|ref|XM_005217815.2|",1433,0,"PREDICTED: Bos taurus serine dehydratase (SDS), transcript variant X1, mRNA","Q0VCW4",587,0,"L-serine dehydratase/L-threonine deaminase","YCL064c",129,{"v":4e-32,"d":"4.00E-32"},"COG1171","pfam00291","PALP","Pyridoxal-phosphate dependent enzyme. Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.","GO:0006094|gluconeogenesis;GO:0006565|L-serine catabolic process;GO:0042866|pyruvate biosynthetic process;","GO:0005737|cytoplasm;","GO:0003941|L-serine ammonia-lyase activity;GO:0004794|L-threonine ammonia-lyase activity;GO:0042803|protein homodimerization activity;GO:0030170|pyridoxal phosphate binding;","K17989","SDS, SDH, CHA1; L-serine/L-threonine ammonia-lyase [EC:4.3.1.17 4.3.1.19]"]
["gene21486",299,329,466,328.864145534371,102,92,105,109.789354833477,2.99541012908925,1.58275354915576,{"v":7.37963195648908e-07,"d":"7.38E-07"},{"v":4.65814777324314e-05,"d":"4.66E-05"},"up","yes","DYNLL1","protein_coding","chrNC_037344.1:62791482-62793912:+","gi|556732732|ref|XP_005962028.1|",631,{"v":1e-80,"d":"1.00E-80"},"PREDICTED: dynein light chain 1, cytoplasmic [Pantholops hodgsonii]","gi|56710335|ref|NM_001003901.1|",658,0,"Bos taurus dynein, light chain, LC8-type 1 (DYNLL1), mRNA","P63170",190,{"v":3e-60,"d":"3.00E-60"},"Dynein light chain 1, cytoplasmic",".",".",".",".","pfam01221","Dynein_light","Dynein light chain type 1.","GO:0006915|apoptotic process;GO:0060271|cilium morphogenesis;GO:0042326|negative regulation of phosphorylation;GO:0042133|neurotransmitter metabolic process;GO:0006809|nitric oxide biosynthetic process;GO:2000582|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0006355|regulation of transcription, DNA-templated;GO:0007286|spermatid development;GO:0006351|transcription, DNA-templated;GO:0010970|microtubule-based transport;","GO:1904115|axon cytoplasm;GO:0005813|centrosome;GO:0008180|COP9 signalosome;GO:0005868|cytoplasmic dynein complex;GO:0000776|kinetochore;GO:0005874|microtubule;GO:0005739|mitochondrion;GO:0072686|mitotic spindle;GO:0005634|nucleus;GO:0030141|secretory granule;","GO:0008092|cytoskeletal protein binding;GO:0045505|dynein intermediate chain binding;GO:0051959|dynein light intermediate chain binding;GO:0019899|enzyme binding;GO:0004857|enzyme inhibitor activity;GO:0003774|motor activity;GO:0030235|nitric-oxide synthase regulator activity;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0097110|scaffold protein binding;","K10418","DYNLL; dynein light chain LC8-type"]
["gene21512",34,493,492,321.529849636467,15,14,20,17.9638050876903,17.8987607618162,4.16178779943431,{"v":1.02045520702887e-27,"d":"1.02E-27"},{"v":2.07961482226719e-24,"d":"2.08E-24"},"up","yes","FAM222A","protein_coding","chrNC_037344.1:63458109-63518440:-","gi|332309223|ref|NP_001193794.1|",924,{"v":3e-109,"d":"3.00E-109"},"protein FAM222A [Bos taurus]","gi|332309222|ref|NM_001206865.1|",2550,0,"Bos taurus family with sequence similarity 222, member A (FAM222A), mRNA",".",".",".",".",".",".",".",".","pfam15258","FAM222A","Protein family of FAM222A. This protein family, FAM222A are a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 411 and 562 amino acids in length. In humans, the gene encoding this protein domain lies in the position, chromosome 12 open reading frame 34.",".",".",".",".","."]
["gene2155",1122,2368,2288,1771.14903378678,774,794,759,854.663053916729,2.07233602256468,1.05125795031354,{"v":4.76530342655669e-05,"d":"4.77E-05"},0.00154323350809409,"up","yes","CCNYL1","protein_coding","chrNC_037329.1:95992629-96029603:+","gi|528900851|ref|XP_003581905.2|",1820,0,"PREDICTED: cyclin-Y-like protein 1 isoform X1 [Bos taurus]","gi|982977596|ref|XM_003581857.4|",3435,0,"PREDICTED: Bos taurus cyclin Y like 1 (CCNYL1), transcript variant X1, mRNA","Q8N7R7",664,0,"Cyclin-Y-like protein 1",".",".",".",".","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;",".","GO:0019901|protein kinase binding;",".","."]
["gene21553",275,385,368,310.863457792277,132,112,160,148.195657783741,2.09765564282533,1.06877786039172,0.00083616388755971,0.0157990674675272,"up","yes","SRRD","protein_coding","chrNC_037344.1:66140596-66172084:+","gi|982950862|ref|XP_015331054.1|",1405,{"v":1e-180,"d":"1.00E-180"},"PREDICTED: SRR1-like protein [Bos taurus]","gi|742220032|ref|XM_010828707.1|",1320,0,"PREDICTED: Bison bison bison SRR1 domain containing (SRRD), mRNA","Q9UH36",412,{"v":2e-131,"d":"2.00E-131"},"SRR1-like protein",".",".",".",".","pfam07985","SRR1","SRR1. SRR1 proteins are signalling proteins involved in regulating the circadian clock in Arabidopsis.","GO:0048511|rhythmic process;",".",".",".","."]
["gene21564",6203,16797,8838,9835.66079355654,745,1364,1047,1156.96688549988,8.50124659298864,3.08767440850408,{"v":2.18321559119555e-14,"d":"2.18E-14"},{"v":6.84498066290112e-12,"d":"6.84E-12"},"up","yes","MN1","protein_coding","chrNC_037344.1:67173207-67224235:-","gi|965793749|ref|XP_014964689.1|",4552,0,"PREDICTED: probable tumor suppressor protein MN1 [Ovis aries musimon]","gi|965793748|ref|XM_015109203.1|",7427,0,"PREDICTED: Ovis aries musimon probable tumor suppressor protein MN1 (LOC105606617), transcript variant X1, mRNA","Q10571",1588,0,"Transcriptional activator MN1",".",".",".",".","pfam03635","Vps35","Vacuolar protein sorting-associated protein 35. Vacuolar protein sorting-associated protein (Vps) 35 is one of around 50 proteins involved in protein trafficking. In particular, Vps35 assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps26 and Vps29. Vps35 contains a central region of weaker sequence similarity, thought to indicate the presence of at least three domains.","GO:0001957|intramembranous ossification;GO:0007275|multicellular organismal development;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;",".",".",".","."]
["gene21592",284,1495,1261,951.235309655155,394,464,415,467.350608252042,2.03537834948564,1.02529699704242,0.000207425872248255,0.00520041086213968,"up","yes","NIPSNAP1","protein_coding","chrNC_037344.1:68732899-68748529:-","gi|115496626|ref|NP_001069824.1|",1416,0,"protein NipSnap homolog 1 [Bos taurus]","gi|115496625|ref|NM_001076356.1|",2473,0,"Bos taurus nipsnap homolog 1 (C. elegans) (NIPSNAP1), mRNA","O55125",536,0,"Protein NipSnap homolog 1",".",".",".",".","pfam07978","NIPSNAP","NIPSNAP. Members of this family include many hypothetical proteins. It also includes members of the NIPSNAP family which have putative roles in vesicular transport. This domain is often found in duplicate.","GO:0019233|sensory perception of pain;","GO:0016020|membrane;GO:0005743|mitochondrial inner membrane;GO:0005739|mitochondrion;GO:0097060|synaptic membrane;","GO:0042165|neurotransmitter binding;",".","."]
["gene21708",295,57,102,126.890169209484,41,43,64,54.2072220251338,2.34083512249806,1.22702332132248,0.00330001298645364,0.0443071390665923,"up","yes","GGT5","protein_coding","chrNC_037344.1:71443755-71455166:-","gi|803309496|ref|XP_012013132.1|",2831,0,"PREDICTED: gamma-glutamyltransferase 5 isoform X2 [Ovis aries musimon]","gi|594047498|ref|XM_006048105.1|",2437,0,"PREDICTED: Bubalus bubalis gamma-glutamyltransferase 5 (GGT5), transcript variant X2, mRNA","P36269",872,0,"Glutathione hydrolase 5 proenzyme","SPAC664.09",227,{"v":1e-61,"d":"1.00E-61"},"COG0405","pfam01019","G_glu_transpept","Gamma-glutamyltranspeptidase.","GO:0006520|cellular amino acid metabolic process;GO:0006631|fatty acid metabolic process;GO:0006750|glutathione biosynthetic process;GO:0006751|glutathione catabolic process;GO:0006954|inflammatory response;GO:1901750|leukotriene D4 biosynthetic process;GO:0006691|leukotriene metabolic process;GO:0006508|proteolysis;","GO:0016021|integral component of membrane;GO:0031226|intrinsic component of plasma membrane;GO:0005886|plasma membrane;","GO:0036374|glutathione hydrolase activity;GO:0000048|peptidyltransferase activity;","K18592","GGT1_5; gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14]"]
["gene21753",855,1289,1221,1020.25647062775,166,363,278,295.61245350386,3.45133115514846,1.78715290697232,{"v":6.33914138682509e-05,"d":"6.34E-05"},0.00198313643538933,"up","yes","P2RX6","protein_coding","chrNC_037344.1:72362498-72372417:+","gi|982951259|ref|XP_010812593.2|",1963,0,"PREDICTED: P2X purinoceptor 6 isoform X2 [Bos taurus]","gi|982998716|ref|XM_015467230.1|",2580,0,"PREDICTED: Bos taurus purinergic receptor P2X, ligand gated ion channel, 6 (P2RX6), transcript variant X2, mRNA","O15547",624,0,"P2X purinoceptor 6",".",".",".",".","pfam00864","P2X_receptor","ATP P2X receptor.","GO:0007596|blood coagulation;GO:0006936|muscle contraction;GO:0051260|protein homooligomerization;GO:0033198|response to ATP;GO:0007165|signal transduction;","GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0005639|integral component of nuclear inner membrane;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0098794|postsynapse;","GO:0005524|ATP binding;GO:0015267|channel activity;GO:0004931|extracellular ATP-gated cation channel activity;GO:0042802|identical protein binding;GO:0001614|purinergic nucleotide receptor activity;GO:0004888|transmembrane signaling receptor activity;","K05221","P2RX6, P2RXL1; P2X purinoceptor 6"]
["gene21764",636,426,432,438.040655688538,201,164,209,210.756681128158,2.07841883514085,1.0554864100137,0.000314996268750274,0.0072829485767537,"up","yes","ZNF74","protein_coding","chrNC_037344.1:72542299-72553514:-","gi|296478311|tpg|DAA20426.1|",2513,0,"TPA: zinc finger protein 354B-like [Bos taurus]","gi|982951088|ref|XM_010814217.2|",2856,0,"PREDICTED: Bos taurus zinc finger protein 74 (ZNF74), transcript variant X5, mRNA","Q16587",589,0,"Zinc finger protein 74",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0007275|multicellular organismal development;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0015629|actin cytoskeleton;GO:0005654|nucleoplasm;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0003723|RNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["gene21767",1,23,1,8.10525149219592,0,0,0,0,"Inf","Inf",0.00203300553152298,0.0311847746343452,"up","yes","TSSK1B","protein_coding","chrNC_037344.1:72591117-72592556:+","gi|296478282|tpg|DAA20397.1|",1843,0,"TPA: testis-specific serine kinase 1 [Bos taurus]","gi|402692913|ref|NM_001083710.2|",1431,0,"Bos taurus testis-specific serine kinase 1B (TSSK1B), mRNA","Q3SZW1",714,0,"Testis-specific serine/threonine-protein kinase 1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0007275|multicellular organismal development;GO:0006468|protein phosphorylation;GO:0007286|spermatid development;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0031514|motile cilium;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004674|protein serine/threonine kinase activity;","K08811","TSSK, STK22; testis-specific serine kinase [EC:2.7.11.1]"]
["gene21768",0,22,1,7.51691057615312,0,0,0,0,"Inf","Inf",0.00299575321129835,0.0413306745026854,"up","yes","TSSK2","protein_coding","chrNC_037344.1:72595682-72597020:+","gi|528918616|ref|XP_005195214.1|",1903,0,"PREDICTED: testis-specific serine/threonine-protein kinase 2 [Bos taurus]","gi|982998783|ref|XM_005195157.3|",1339,0,"PREDICTED: Bos taurus testis-specific serine kinase 2 (TSSK2), mRNA","O54863",702,0,"Testis-specific serine/threonine-protein kinase 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0007275|multicellular organismal development;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0007286|spermatid development;","GO:0001669|acrosomal vesicle;GO:0005814|centriole;GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;","K08811","TSSK, STK22; testis-specific serine kinase [EC:2.7.11.1]"]
["gene2177",107,102,809,309.775291209501,5,9,5,6.97659301409563,44.4020871768821,5.47255558878176,{"v":6.12957398918048e-37,"d":"6.13E-37"},{"v":1.94314306094787e-33,"d":"1.94E-33"},"up","yes","UNC80","protein_coding","chrNC_037329.1:97594858-97825043:+","gi|594100257|ref|XP_006073233.1|",16183,0,"PREDICTED: protein unc-80 homolog isoform X1 [Bubalus bubalis]","gi|965922329|ref|XM_012144806.2|",8934,0,"PREDICTED: Ovis aries unc-80 homolog, NALCN activator (UNC80), transcript variant X7, mRNA","Q8N2C7",3397,0,"Protein unc-80 homolog",".",".",".",".","pfam06293","Kdo","Lipopolysaccharide kinase (Kdo/WaaP) family. These lipopolysaccharide kinases are related to protein kinases pfam00069. This family includes waaP (rfaP) gene product is required for the addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. It has previously been shown that WaaP is necessary for resistance to hydrophobic and polycationic antimicrobials in Escherichia coli and that it is required for virulence in invasive strains of S. enterica.","GO:0034220|ion transmembrane transport;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".",".","."]
["gene21781",1540,1973,1151,1401.4437660853,96,90,118,111.505418704281,12.5683915846458,3.65172813037955,{"v":6.56686970878444e-43,"d":"6.57E-43"},{"v":2.67656228087613e-39,"d":"2.68E-39"},"up","yes","TBX1","protein_coding","chrNC_037344.1:72822848-72830131:+","gi|803322805|ref|XP_012019613.1|",1469,0,"PREDICTED: T-box transcription factor TBX1 isoform X2 [Ovis aries musimon]","gi|965904811|ref|XM_012164223.2|",1567,0,"PREDICTED: Ovis aries musimon T-box transcription factor TBX1 (LOC105605671), transcript variant X2, mRNA","P70323",546,0,"T-box transcription factor TBX1",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0001525|angiogenesis;GO:0009952|anterior/posterior pattern specification;GO:0035909|aorta morphogenesis;GO:0048844|artery morphogenesis;GO:0001568|blood vessel development;GO:0048514|blood vessel morphogenesis;GO:0001974|blood vessel remodeling;GO:0001569|patterning of blood vessels;GO:0001708|cell fate specification;GO:0008283|cell proliferation;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0071300|cellular response to retinoic acid;GO:0090103|cochlea morphogenesis;GO:0060982|coronary artery morphogenesis;GO:0007368|determination of left/right symmetry;GO:0042471|ear morphogenesis;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0048703|embryonic viscerocranium morphogenesis;GO:0070166|enamel mineralization;GO:0030855|epithelial cell differentiation;GO:0060325|face morphogenesis;GO:0007507|heart development;GO:0003007|heart morphogenesis;GO:0042472|inner ear morphogenesis;GO:0001945|lymph vessel development;GO:0097152|mesenchymal cell apoptotic process;GO:0007498|mesoderm development;GO:0042474|middle ear morphogenesis;GO:0042693|muscle cell fate commitment;GO:0007517|muscle organ development;GO:0048644|muscle organ morphogenesis;GO:0060415|muscle tissue morphogenesis;GO:0045596|negative regulation of cell differentiation;GO:2001054|negative regulation of mesenchymal cell apoptotic process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0001755|neural crest cell migration;GO:0042475|odontogenesis of dentin-containing tooth;GO:0071600|otic vesicle morphogenesis;GO:0042473|outer ear morphogenesis;GO:0003151|outflow tract morphogenesis;GO:0003148|outflow tract septum morphogenesis;GO:0060017|parathyroid gland development;GO:0007389|pattern specification process;GO:0060037|pharyngeal system development;GO:0008284|positive regulation of cell proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0043410|positive regulation of MAPK cascade;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0001934|positive regulation of protein phosphorylation;GO:0072513|positive regulation of secondary heart field cardioblast proliferation;GO:2001037|positive regulation of tongue muscle cell differentiation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:2000027|regulation of organ morphogenesis;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0048384|retinoic acid receptor signaling pathway;GO:0048752|semicircular canal morphogenesis;GO:0007605|sensory perception of sound;GO:0035176|social behavior;GO:0060023|soft palate development;GO:0048538|thymus development;GO:0030878|thyroid gland development;GO:0043587|tongue morphogenesis;GO:0021644|vagus nerve morphogenesis;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0042803|protein homodimerization activity;GO:0001162|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K10175","TBX1; T-box protein 1"]
["gene21882",3628,8433,7820,6110.87546680632,768,1030,933,1001.83879424799,6.09965944809845,2.60872869738788,{"v":1.95240413268306e-24,"d":"1.95E-24"},{"v":3.09466901719891e-21,"d":"3.09E-21"},"up","yes","MAF","protein_coding","chrNC_037345.1:6171287-6524071:-","gi|767989917|ref|XP_011521386.1|",690,{"v":2e-78,"d":"2.00E-78"},"PREDICTED: transcription factor Maf isoform X1 [Homo sapiens]","gi|965840713|ref|XM_012135561.2|",2472,0,"PREDICTED: Ovis aries musimon transcription factor Maf (LOC105609374), transcript variant X1, mRNA","P23091",256,{"v":3e-75,"d":"3.00E-75"},"Transforming protein Maf",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.","GO:0006351|transcription, DNA-templated;","GO:0042025|host cell nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;",".","."]
["gene21928",0,231,1,76.0099055303308,0,2,4,2.17786669179185,34.9010827048341,5.12519988744453,{"v":1.08958947736938e-05,"d":"1.09E-05"},0.00046123260205973,"up","yes","DNAAF1","protein_coding","chrNC_037345.1:10448643-10469366:+","gi|164448610|ref|NP_001030422.2|",2994,0,"dynein assembly factor 1, axonemal [Bos taurus]","gi|164448609|ref|NM_001035345.2|",2069,0,"Bos taurus dynein, axonemal, assembly factor 1 (DNAAF1), mRNA","Q3SYS4",1152,0,"Dynein assembly factor 1, axonemal","SPAC4A8.12c",62,{"v":2e-09,"d":"2.00E-09"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0060271|cilium morphogenesis;GO:0044458|motile cilium assembly;","GO:0005930|axoneme;","GO:0070840|dynein complex binding;",".","."]
["gene21984",660,720,709,625.71730356879,216,301,261,285.411089632054,2.1923370404964,1.13246960909865,{"v":4.55459825442921e-05,"d":"4.55E-05"},0.00148681055831945,"up","yes","BANP","protein_coding","chrNC_037345.1:13381097-13450242:+","gi|742140080|ref|XP_010842271.1|",2275,0,"PREDICTED: protein BANP isoform X4 [Bison bison bison]","gi|742140079|ref|XM_010843969.1|",1503,0,"PREDICTED: Bison bison bison BTG3 associated nuclear protein (BANP), transcript variant X4, mRNA","Q0VCW3",657,0,"Protein BANP",".",".",".",".","pfam10523","BEN","BEN domain. The BEN domain is found in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.","GO:0007049|cell cycle;GO:0006325|chromatin organization;GO:0007275|multicellular organismal development;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;",".","."]
["gene21985",44,150,198,121.435157756186,41,40,39,44.0819371068344,2.75476001569266,1.46192664211747,0.000678372550824057,0.0134875590575339,"up","yes","ZNF469","protein_coding","chrNC_037345.1:13460966-13711181:+","gi|594037177|ref|XP_006043228.1|",15933,0,"PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 469 [Bubalus bubalis]","gi|594037176|ref|XM_006043166.1|",11946,0,"PREDICTED: Bubalus bubalis zinc finger protein 469 (ZNF469), mRNA","Q96JG9",2686,0,"Zinc finger protein 469",".",".",".",".","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["gene21992",315,563,729,490.493043897024,22,76,54,55.6064892037403,8.82078784186273,3.14090751800361,{"v":2.33477343199981e-06,"d":"2.33E-06"},0.00012404733852586,"up","yes","SNAI3","protein_coding","chrNC_037345.1:13911510-13919731:-","gi|300798047|ref|NP_001179562.1|",1463,0,"zinc finger protein SNAI3 [Bos taurus]","gi|982951702|ref|XM_005218623.3|",2821,0,"PREDICTED: Bos taurus snail family zinc finger 3 (SNAI3), transcript variant X1, mRNA","Q3KNW1",380,{"v":3e-122,"d":"3.00E-122"},"Zinc finger protein SNAI3",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0005507|copper ion binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0000982|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09217","SNAI3; snail 3"]
["gene21995",2420,1739,2918,2096.79020415234,695,834,810,858.224494862817,2.44317217313577,1.28875553555632,{"v":1.80900249016049e-07,"d":"1.81E-07"},{"v":1.39117655112585e-05,"d":"1.39E-05"},"up","yes","PIEZO1","protein_coding","chrNC_037345.1:13939776-13995891:-","gi|803313346|ref|XP_012015002.1|",10794,0,"PREDICTED: piezo-type mechanosensitive ion channel component 1 isoform X4 [Ovis aries musimon]","gi|982999097|ref|XM_015467307.1|",7297,0,"PREDICTED: Bos taurus piezo-type mechanosensitive ion channel component 1 (PIEZO1), transcript variant X1, mRNA","Q92508",2503,0,"Piezo-type mechanosensitive ion channel component 1",".",".",".",".","pfam12166","DUF3595","Protein of unknown function (DUF3595). This family of proteins is functionally uncharacterized.This family of proteins is found in eukaryotes. Proteins in this family are typically between 578 and 2525 amino acids in length.","GO:0006812|cation transport;GO:0071260|cellular response to mechanical stimulus;GO:0050982|detection of mechanical stimulus;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0033625|positive regulation of integrin activation;GO:0042391|regulation of membrane potential;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0016021|integral component of membrane;GO:0031258|lamellipodium membrane;GO:0005886|plasma membrane;","GO:0005261|cation channel activity;GO:0008381|mechanically-gated ion channel activity;",".","."]
["gene22002",3081,1398,2648,2074.38759401744,760,876,870,919.591271929585,2.25577129463695,1.17362080496236,{"v":1.82877151301649e-06,"d":"1.83E-06"},0.000101708927949071,"up","yes","CBFA2T3","protein_coding","chrNC_037345.1:14049658-14127732:-","gi|803313380|ref|XP_012015019.1|",3194,0,"PREDICTED: protein CBFA2T3 isoform X2 [Ovis aries musimon]","gi|982999115|ref|XM_005192664.3|",4044,0,"PREDICTED: Bos taurus core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (CBFA2T3), transcript variant X1, mRNA","O75081",1004,0,"Protein CBFA2T3",".",".",".",".","pfam07531","TAFH","NHR1 homology to TAF. This corresponds to the region NHR1 that is conserved between the product of the nervy gene in Drosophila and the human mtg8b protein, which is hypothesised to be a transcription factor.","GO:0008283|cell proliferation;GO:0030851|granulocyte differentiation;GO:0008285|negative regulation of cell proliferation;GO:0045820|negative regulation of glycolytic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1903715|regulation of aerobic respiration;GO:0001666|response to hypoxia;GO:0006351|transcription, DNA-templated;","GO:0000139|Golgi membrane;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0003714|transcription corepressor activity;",".","."]
["gene22036",109,11,18,37.5410166913654,4,9,7,7.32477070081722,5.12521391108898,2.35761221964773,0.000703507743062906,0.0138713057479805,"up","yes","SHCBP1","protein_coding","chrNC_037345.1:14881869-14919139:-","gi|300796923|ref|NP_001179508.1|",3368,0,"SHC SH2 domain-binding protein 1 [Bos taurus]","gi|300796922|ref|NM_001192579.1|",2468,0,"Bos taurus SHC SH2-domain binding protein 1 (SHCBP1), mRNA","Q8NEM2",1185,0,"SHC SH2 domain-binding protein 1",".",".",".",".","pfam13229","Beta_helix","Right handed beta helix region. This region contains a parallel beta helix region that shares some similarity with Pectate lyases.","GO:0008543|fibroblast growth factor receptor signaling pathway;GO:2000177|regulation of neural precursor cell proliferation;","GO:0005737|cytoplasm;GO:0030496|midbody;GO:0005819|spindle;","GO:0042169|SH2 domain binding;",".","."]
["gene22041",9281,294,1088,2849.34159612923,72,116,107,108.105959560584,26.356933583596,4.72011062907733,{"v":1.00091622537627e-52,"d":"1.00E-52"},{"v":7.13928520655261e-49,"d":"7.14E-49"},"up","yes","MYLK3","protein_coding","chrNC_037345.1:15032402-15089534:-","gi|528990986|ref|XP_005218847.1|",3983,0,"PREDICTED: myosin light chain kinase 3 isoform X1 [Bos taurus]","gi|982999178|ref|XM_015467330.1|",9601,0,"PREDICTED: Bos taurus myosin light chain kinase 3 (MYLK3), transcript variant X1, mRNA","Q32MK0",1042,0,"Myosin light chain kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0055003|cardiac myofibril assembly;GO:0071347|cellular response to interleukin-1;GO:0035556|intracellular signal transduction;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0060298|positive regulation of sarcomere organization;GO:0006468|protein phosphorylation;GO:0002528|regulation of vascular permeability involved in acute inflammatory response;GO:0045214|sarcomere organization;GO:0048769|sarcomerogenesis;","GO:0015629|actin cytoskeleton;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005622|intracellular;","GO:0005524|ATP binding;GO:0004683|calmodulin-dependent protein kinase activity;GO:0004687|myosin light chain kinase activity;","K00907","MYLK; myosin-light-chain kinase [EC:2.7.11.18]"]
["gene22053",12539,20257,13890,14172.4512851937,4840,5889,5178,5839.34496668456,2.42706183074511,1.27921086241286,{"v":5.70270988029337e-06,"d":"5.70E-06"},0.00026412989544586,"up","yes","PHKB","protein_coding","chrNC_037345.1:15865447-16092557:+","gi|982999190|ref|XP_015322818.1|",5682,0,"PREDICTED: LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta isoform X2 [Bos taurus]","gi|982999189|ref|XM_015467332.1|",3984,0,"PREDICTED: Bos taurus phosphorylase kinase, beta (PHKB), transcript variant X2, mRNA","P12798",2078,0,"Phosphorylase b kinase regulatory subunit beta",".",".",".",".","pfam00723","Glyco_hydro_15","Glycosyl hydrolases family 15. In higher organisms this family is represented by phosphorylase kinase subunits.","GO:0005977|glycogen metabolic process;","GO:0005886|plasma membrane;","GO:0005516|calmodulin binding;GO:0003824|catalytic activity;","K07190","PHKA_B; phosphorylase kinase alpha/beta subunit"]
["gene22128",10,59,163,72.0024017196716,6,9,6,7.71133399273375,9.33721737218465,3.22299266969105,{"v":4.72724914777819e-08,"d":"4.73E-08"},{"v":4.29532310303374e-06,"d":"4.30E-06"},"up","yes","MT1A","protein_coding","chrNC_037345.1:24023719-24025823:-","gi|594059181|ref|XP_006053735.1|",210,{"v":2e-18,"d":"2.00E-18"},"PREDICTED: metallothionein-1A-like [Bubalus bubalis]","gi|163343|gb|M76977.1|BOVMETALL",388,0,"B.taurus metallothionein gene, complete cds",".",".",".",".",".",".",".",".","pfam00131","Metallothio","Metallothionein.",".",".",".",".","."]
["gene22131",369,714,1240,710.991223020115,76,191,164,157.700554237367,4.50848905673437,2.17264401982609,{"v":8.38736355823476e-05,"d":"8.39E-05"},0.00251365409327727,"up","yes","MT2A","protein_coding","chrNC_037345.1:24042365-24043331:-","gi|685613325|ref|XP_009194740.1|",140,{"v":6e-09,"d":"6.00E-09"},"PREDICTED: uncharacterized protein LOC101024326 isoform X1 [Papio anubis]","gi|262073070|ref|NM_001075140.1|",417,0,"Bos taurus metallothionein 2A (MT2A), mRNA","P68302",45.4,{"v":4e-06,"d":"4.00E-06"},"Metallothionein-2",".",".",".",".","pfam00131","Metallothio","Metallothionein.","GO:0071294|cellular response to zinc ion;GO:0045926|negative regulation of growth;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0008270|zinc ion binding;","K14739","MT1_2; metallothionein 1/2"]
["gene22171",1540,586,883,864.590747218782,250,197,224,246.596500650668,3.50609495648753,1.80986506951403,{"v":8.00191065075575e-12,"d":"8.00E-12"},{"v":1.64246412069577e-09,"d":"1.64E-09"},"up","yes","ADGRG1","protein_coding","chrNC_037345.1:25595290-25641532:+","gi|594070445|ref|XP_006059105.1|",3580,0,"PREDICTED: G-protein coupled receptor 56 isoform X2 [Bubalus bubalis]","gi|139949072|ref|NM_001083656.1|",3398,0,"Bos taurus adhesion G protein-coupled receptor G1 (ADGRG1), mRNA","Q50DM8",1118,0,"Adhesion G-protein coupled receptor G1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0001525|angiogenesis;GO:0007155|cell adhesion;GO:0016477|cell migration;GO:0007166|cell surface receptor signaling pathway;GO:0021801|cerebral cortex radial glia guided migration;GO:0021796|cerebral cortex regionalization;GO:0021819|layer formation in cerebral cortex;GO:0008285|negative regulation of cell proliferation;GO:2001223|negative regulation of neuron migration;GO:0045785|positive regulation of cell adhesion;GO:2000179|positive regulation of neural precursor cell proliferation;GO:0035025|positive regulation of Rho protein signal transduction;GO:0070528|protein kinase C signaling;GO:0007266|Rho protein signal transduction;GO:0072520|seminiferous tubule development;GO:0010573|vascular endothelial growth factor production;","GO:0005576|extracellular region;GO:0097451|glial limiting end-foot;GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0045121|membrane raft;GO:0005886|plasma membrane;","GO:0005518|collagen binding;GO:0050840|extracellular matrix binding;GO:0004930|G-protein coupled receptor activity;GO:0008201|heparin binding;","K08450","GPR56; G protein-coupled receptor 56"]
["gene22181",847,1711,1149,1134.35558773846,210,247,275,268.40477280386,4.22628694672059,2.07939072339137,{"v":3.67457502852175e-15,"d":"3.67E-15"},{"v":1.29431234739202e-12,"d":"1.29E-12"},"up","yes","MMP15","protein_coding","chrNC_037345.1:25939947-25960720:+","gi|300794469|ref|NP_001178363.1|",2673,0,"matrix metalloproteinase-15 precursor [Bos taurus]","gi|300794468|ref|NM_001191434.1|",3595,0,"Bos taurus matrix metallopeptidase 15 (MMP15), mRNA","P51511",990,0,"Matrix metalloproteinase-15",".",".",".",".","pfam00413","Peptidase_M10","Matrixin. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.","GO:0006464|cellular protein modification process;GO:0030574|collagen catabolic process;GO:0035987|endodermal cell differentiation;GO:0022617|extracellular matrix disassembly;GO:0006508|proteolysis;GO:0032355|response to estradiol;","GO:0031012|extracellular matrix;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0008047|enzyme activator activity;GO:0070006|metalloaminopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K07995","MMP15; matrix metalloproteinase-15 (membrane-inserted) [EC:3.4.24.-]"]
["gene2221",12690,22395,50486,26151.8890956218,2729,2761,2964,3103.18943746981,8.42742269609707,3.0750914885733,{"v":1.07808172759573e-23,"d":"1.08E-23"},{"v":1.36171751212963e-20,"d":"1.36E-20"},"up","yes","IGFBP5","protein_coding","chrNC_037329.1:104656175-104680027:-","gi|741917592|ref|XP_010800619.1|",1419,{"v":4e-177,"d":"4.00E-177"},"PREDICTED: insulin-like growth factor-binding protein 5 isoform X1 [Bos taurus]","gi|741917591|ref|XM_010802317.1|",5581,0,"PREDICTED: Bos taurus insulin like growth factor binding protein 5 (IGFBP5), transcript variant X1, mRNA","Q05717",503,{"v":1e-161,"d":"1.00E-161"},"Insulin-like growth factor-binding protein 5",".",".",".",".","pfam00086","Thyroglobulin_1","Thyroglobulin type-1 repeat. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.","GO:0071320|cellular response to cAMP;GO:0007565|female pregnancy;GO:0042593|glucose homeostasis;GO:0006006|glucose metabolic process;GO:0031069|hair follicle morphogenesis;GO:0048286|lung alveolus development;GO:0060056|mammary gland involution;GO:0045926|negative regulation of growth;GO:0043569|negative regulation of insulin-like growth factor receptor signaling pathway;GO:1901862|negative regulation of muscle tissue development;GO:0045668|negative regulation of osteoblast differentiation;GO:1904205|negative regulation of skeletal muscle hypertrophy;GO:0014912|negative regulation of smooth muscle cell migration;GO:0048662|negative regulation of smooth muscle cell proliferation;GO:0017148|negative regulation of translation;GO:0001649|osteoblast differentiation;GO:0043568|positive regulation of insulin-like growth factor receptor signaling pathway;GO:0051897|positive regulation of protein kinase B signaling;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:0001558|regulation of cell growth;GO:0010906|regulation of glucose metabolic process;GO:0043567|regulation of insulin-like growth factor receptor signaling pathway;GO:0060416|response to growth hormone;GO:0051146|striated muscle cell differentiation;GO:0044342|type B pancreatic cell proliferation;","GO:0005615|extracellular space;GO:0042567|insulin-like growth factor ternary complex;","GO:0001968|fibronectin binding;GO:0031994|insulin-like growth factor I binding;GO:0031995|insulin-like growth factor II binding;",".","."]
["gene22214",5689,2031,2941,3051.52492527122,765,892,736,878.961546431606,3.47173882368318,1.795658418995,{"v":4.77962963591111e-13,"d":"4.78E-13"},{"v":1.23970557401982e-10,"d":"1.24E-10"},"up","yes","CDH5","protein_coding","chrNC_037345.1:34122721-34161590:+","gi|555969230|ref|XP_005896642.1|",3854,0,"PREDICTED: cadherin-5 [Bos mutus]","gi|965789522|ref|XM_012110403.2|",4537,0,"PREDICTED: Ovis aries musimon cadherin 5, type 2 (vascular endothelium) (CDH5), transcript variant X3, mRNA","Q6URK6",1481,0,"Cadherin-5",".",".",".",".","pfam01049","Cadherin_C","Cadherin cytoplasmic region. Cadherins are vital in cell-cell adhesion during tissue differentiation. Cadherins are linked to the cytoskeleton by catenins. Catenins bind to the cytoplasmic tail of the cadherin. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the binding that it is mediated by cadherins is the juxtamembrane region of the cadherin. This region induces clustering and also binds to the protein p120ctn.","GO:0001955|blood vessel maturation;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:2000114|regulation of establishment of cell polarity;","GO:0030054|cell junction;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;","K06533","CDH5; cadherin 5, type 2, VE-cadherin"]
["gene2223",0,23,0,7.53750662175161,0,0,0,0,"Inf","Inf",0.00296743973843368,0.0409876098953687,"up","yes","TNP1","protein_coding","chrNC_037329.1:104859771-104860361:-","gi|965922418|ref|XP_014949014.1|",280,{"v":1e-31,"d":"1.00E-31"},"PREDICTED: spermatid nuclear transition protein 1 isoform X1 [Ovis aries]","gi|74267769|gb|BC102598.1|",371,0,"Bos taurus transition protein 1 (during histone to protamine replacement), mRNA (cDNA clone MGC:127897 IMAGE:7961570), complete cds","P17305",70.1,{"v":3e-15,"d":"3.00E-15"},"Spermatid nuclear transition protein 1",".",".",".",".","pfam02079","TP1","Nuclear transition protein 1.","GO:0006338|chromatin remodeling;GO:0006342|chromatin silencing;GO:0030317|sperm motility;GO:0007275|multicellular organismal development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0006337|nucleosome disassembly;GO:0010954|positive regulation of protein processing;GO:0019953|sexual reproduction;GO:0000012|single strand break repair;GO:0007286|spermatid development;GO:0007290|spermatid nucleus elongation;GO:0035093|spermatogenesis, exchange of chromosomal proteins;","GO:0001673|male germ cell nucleus;GO:0000788|nuclear nucleosome;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;",".","."]
["gene22252",6642,14810,11299,10054.7257062537,2930,3984,3609,3859.97013352341,2.60487137424446,1.38121213552829,{"v":5.24199183824426e-07,"d":"5.24E-07"},{"v":3.50583074382668e-05,"d":"3.51E-05"},"up","yes","FHOD1","protein_coding","chrNC_037345.1:34857828-34874215:-","gi|803210937|ref|XP_011965892.1|",5057,0,"PREDICTED: FH1/FH2 domain-containing protein 1 isoform X2 [Ovis aries musimon]","gi|926714296|ref|XM_013971264.1|",3533,0,"PREDICTED: Capra hircus formin homology 2 domain containing 1 (FHOD1), mRNA","Q9Y613",1728,0,"FH1/FH2 domain-containing protein 1",".",".",".",".","pfam02181","FH2","Formin Homology 2 Domain.","GO:0051660|establishment of centrosome localization;GO:0007097|nuclear migration;GO:0051496|positive regulation of stress fiber assembly;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051492|regulation of stress fiber assembly;","GO:0032059|bleb;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0014704|intercalated disc;GO:0016020|membrane;GO:0005634|nucleus;","GO:0003779|actin binding;GO:0042802|identical protein binding;GO:0019904|protein domain specific binding;GO:0043621|protein self-association;",".","."]
["gene22253",1345,1186,1406,1171.02443793671,135,427,309,318.703006665504,3.67434386700268,1.87748664876962,0.000606665941357114,0.0123369821616962,"up","yes","SLC9A5","protein_coding","chrNC_037345.1:34875214-34894809:+","gi|528990438|ref|XP_005218600.1|",2651,0,"PREDICTED: sodium/hydrogen exchanger 5 isoform X2 [Bos taurus]","gi|982951605|ref|XM_005218543.3|",2213,0,"PREDICTED: Bos taurus solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 (SLC9A5), transcript variant X2, mRNA","Q14940",1016,0,"Sodium/hydrogen exchanger 5","SPAC15A10.06",123,{"v":3e-28,"d":"3.00E-28"},"COG0025","pfam00999","Na_H_Exchanger","Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolizing cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.","GO:0006811|ion transport;GO:0071805|potassium ion transmembrane transport;GO:0051453|regulation of intracellular pH;GO:0098719|sodium ion import across plasma membrane;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0015386|potassium:proton antiporter activity;GO:0015385|sodium:proton antiporter activity;","K14723","SLC9A5, NHE5; solute carrier family 9 (sodium/hydrogen exchanger), member 5"]
["gene22415",72,243,222,166.581271760408,43,55,47,53.2220699296718,3.12992846727927,1.6461296855666,{"v":2.81873337239545e-05,"d":"2.82E-05"},0.00100526602309768,"up","yes","SLC7A10","protein_coding","chrNC_037345.1:43644105-43660414:-","gi|641699032|ref|XP_008138003.1|",1735,0,"PREDICTED: asc-type amino acid transporter 1 [Eptesicus fuscus]","gi|742160999|ref|XM_010848941.1|",1187,0,"PREDICTED: Bison bison bison solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 (SLC7A10), transcript variant X3, mRNA","P63116",642,0,"Asc-type amino acid transporter 1","BS_ykbA",129,{"v":9e-31,"d":"9.00E-31"},"COG0531","pfam13520","AA_permease_2","Amino acid permease.","GO:0042941|D-alanine transport;GO:0042942|D-serine transport;GO:0015825|L-serine transport;GO:0015804|neutral amino acid transport;","GO:0097440|apical dendrite;GO:0005887|integral component of plasma membrane;GO:0043025|neuronal cell body;","GO:0015297|antiporter activity;GO:0015194|L-serine transmembrane transporter activity;GO:0015175|neutral amino acid transmembrane transporter activity;",".","."]
["gene2242",143,37,85,75.5000158549108,16,23,28,24.5282444064061,3.07808478274915,1.62203296979712,0.0010095616027841,0.0182187236489774,"up","yes","SLC11A1","protein_coding","chrNC_037329.1:106392721-106403646:+","gi|555955103|ref|XP_005889711.1|",2690,0,"PREDICTED: natural resistance-associated macrophage protein 1 [Bos mutus]","gi|31341436|ref|NM_174652.2|",2249,0,"Bos taurus solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 (SLC11A1), mRNA","Q27981",999,0,"Natural resistance-associated macrophage protein 1","mlr2501",266,{"v":4e-79,"d":"4.00E-79"},"COG1914","pfam01566","Nramp","Natural resistance-associated macrophage protein. The natural resistance-associated macrophage protein (NRAMP) family consists of Nramp1, Nramp2, and yeast proteins Smf1 and Smf2. The NRAMP family is a novel family of functional related proteins defined by a conserved hydrophobic core of ten transmembrane domains. This family of membrane proteins are divalent cation transporters. Nramp1 is an integral membrane protein expressed exclusively in cells of the immune system and is recruited to the membrane of a phagosome upon phagocytosis. By controlling divalent cation concentrations Nramp1 may regulate the interphagosomal replication of bacteria. Mutations in Nramp1 may genetically predispose an individual to susceptibility to diseases including leprosy and tuberculosis conversely this might however provide protection form rheumatoid arthritis. Nramp2 is a multiple divalent cation transporter for Fe2+, Mn2+ and Zn2+ amongst others it is expressed at high levels in the intestine; and is major transferrin-independent iron uptake system in mammals. The yeast proteins Smf1 and Smf2 may also transport divalent cations.","GO:0055072|iron ion homeostasis;","GO:0016021|integral component of membrane;","GO:0046873|metal ion transmembrane transporter activity;","K12347","SLC11A, NRAMP; natural resistance-associated macrophage protein"]
["gene22428",9433,31407,21224,19269.4376956158,5174,7114,6192,6779.76978970997,2.84219645995386,1.50700628083163,{"v":6.98824141833398e-07,"d":"6.99E-07"},{"v":4.46043659746056e-05,"d":"4.46E-05"},"up","yes","GPI","protein_coding","chrNC_037345.1:44784251-44812527:+","gi|440895380|gb|ELR47584.1|",3102,0,"Glucose-6-phosphate isomerase, partial [Bos mutus]","gi|94966764|ref|NM_001040471.1|",2028,0,"Bos taurus glucose-6-phosphate isomerase (GPI), mRNA","Q3ZBD7",1164,0,"Glucose-6-phosphate isomerase","YPO3718",748,0,"COG0166","pfam00342","PGI","Phosphoglucose isomerase. Phosphoglucose isomerase catalyses the interconversion of glucose-6-phosphate and fructose-6-phosphate.","GO:0034101|erythrocyte homeostasis;GO:0006094|gluconeogenesis;GO:0042593|glucose homeostasis;GO:0006096|glycolytic process;GO:0001701|in utero embryonic development;GO:0001707|mesoderm formation;","GO:0060170|ciliary membrane;GO:0005829|cytosol;GO:0005615|extracellular space;GO:0043209|myelin sheath;GO:0005654|nucleoplasm;","GO:0005125|cytokine activity;GO:0004347|glucose-6-phosphate isomerase activity;","K01810","GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9]"]
["gene22477",5,65,2,23.2190085998257,0,0,1,0.360972888453242,64.3234141470248,6.00727207855376,{"v":1.86915184480158e-06,"d":"1.87E-06"},0.000103551012202007,"up","yes","GAPDHS","protein_coding","chrNC_037345.1:46195228-46204432:+","gi|528991507|ref|XP_005219028.1|",1759,0,"PREDICTED: glyceraldehyde-3-phosphate dehydrogenase, testis-specific isoform X1 [Bos taurus]","gi|982952679|ref|XM_005218971.3|",1743,0,"PREDICTED: Bos taurus glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (GAPDHS), transcript variant X1, mRNA","Q2KJE5",666,0,"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific","SPBC32F12.11",465,{"v":2e-159,"d":"2.00E-159"},"COG0057","pfam02800","Gp_dh_C","Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain. GAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.","GO:0006006|glucose metabolic process;GO:0006096|glycolytic process;","GO:0005737|cytoplasm;","GO:0004365|glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity;GO:0051287|NAD binding;GO:0050661|NADP binding;","K10705","GAPDHS; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [EC:1.2.1.12]"]
["gene2248",2660,2376,3074,2416.00691749049,532,1048,778,864.284503495918,2.79538382062626,1.48304638614429,0.000195784358058597,0.00498298262245303,"up","yes","PLCD4","protein_coding","chrNC_037329.1:106571812-106598630:+","gi|741917744|ref|XP_010800675.1|",3937,0,"PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X3 [Bos taurus]","gi|982914780|ref|XM_010802373.2|",5011,0,"PREDICTED: Bos taurus phospholipase C delta 4 (PLCD4), transcript variant X3, mRNA","P21671",1496,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0007340|acrosome reaction;GO:0035556|intracellular signal transduction;GO:0016042|lipid catabolic process;GO:0046488|phosphatidylinositol metabolic process;","GO:0005783|endoplasmic reticulum;GO:0016020|membrane;GO:0005634|nucleus;","GO:0005509|calcium ion binding;GO:0004435|phosphatidylinositol phospholipase C activity;","K05857","PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]"]
["gene22524",2661,1592,2245,1904.73304596824,873,623,1007,918.432496884242,2.07389552572453,1.05234321897491,0.000497492567568106,0.0105140447742856,"up","yes","COX7A1","protein_coding","chrNC_037345.1:46806369-46807949:-","gi|28603808|ref|NP_788847.1|",423,{"v":2e-51,"d":"2.00E-51"},"cytochrome c oxidase subunit 7A1, mitochondrial precursor [Bos taurus]","gi|942092876|ref|XM_005908222.2|",367,0,"PREDICTED: Bos mutus cytochrome c oxidase subunit 7A1, mitochondrial (LOC102282043), mRNA","P07470",167,{"v":7e-53,"d":"7.00E-53"},"Cytochrome c oxidase subunit 7A1, mitochondrial",".",".",".",".","pfam02238","COX7a","Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase, a 13 sub-unit complex, is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of the heart and liver isoforms of cytochrome c oxidase subunit VIIa.",".","GO:0016021|integral component of membrane;GO:0005746|mitochondrial respiratory chain;GO:0005739|mitochondrion;GO:0045277|respiratory chain complex IV;","GO:0004129|cytochrome-c oxidase activity;","K02270","COX7A; cytochrome c oxidase subunit 7a"]
["gene22572",366,239,356,283.047931576913,77,113,112,110.678701746806,2.55738391496881,1.35466875449659,{"v":3.53912290867475e-05,"d":"3.54E-05"},0.00120494887478997,"up","yes","PPP1R14A","protein_coding","chrNC_037345.1:48065738-48069952:-","gi|926714414|ref|XP_005692580.2|",567,{"v":7e-70,"d":"7.00E-70"},"PREDICTED: protein phosphatase 1 regulatory subunit 14A [Capra hircus]","gi|300796505|ref|NM_001193070.1|",754,0,"Bos taurus protein phosphatase 1, regulatory (inhibitor) subunit 14A (PPP1R14A), mRNA","O18734",217,{"v":2e-69,"d":"2.00E-69"},"Protein phosphatase 1 regulatory subunit 14A",".",".",".",".","pfam05361","PP1_inhibitor","PKC-activated protein phosphatase-1 inhibitor. Contractility of vascular smooth muscle depends on phosphorylation of myosin light chains, and is modulated by hormonal control of myosin phosphatase activity. Signaling pathways activate kinases such as PKC or Rho-dependent kinases that phosphorylate the myosin phosphatase inhibitor protein called CPI-17. Phosphorylation of CPI-17 at Thr-38 enhances its inhibitory potency 1000-fold, creating a molecular switch for regulating contraction.","GO:0042325|regulation of phosphorylation;","GO:0005737|cytoplasm;","GO:0004864|protein phosphatase inhibitor activity;","K12328","PPP1R14A, CPI17; protein phosphatase 1 regulatory subunit 14A"]
["gene22606",262,310,273,253.719974580143,82,122,94,109.352918326477,2.32019390486363,1.21424538030771,0.000304499102069772,0.00710356817755737,"up","yes","FBXO17","protein_coding","chrNC_037345.1:48642188-48674144:-","gi|594090683|ref|XP_006068742.1|",912,{"v":3e-115,"d":"3.00E-115"},"PREDICTED: F-box only protein 17 isoform X5 [Bubalus bubalis]","gi|163310726|ref|NM_001103239.2|",1967,0,"Bos taurus F-box protein 17 (FBXO17), mRNA","Q9QZM8",311,{"v":9e-99,"d":"9.00E-99"},"F-box only protein 17",".",".",".",".","pfam04300","FBA","F-box associated region. Members of this family are associated with F-box domains, hence the name FBA. This domain is probably involved in binding other proteins that will be targeted for ubiquitination. Human FBXO2 is involved in binding to N-glycosylated proteins.",".","GO:0019005|SCF ubiquitin ligase complex;","GO:0004842|ubiquitin-protein transferase activity;","K10101","FBXO17, FBXO26; F-box protein 17"]
["gene22631",2228,5493,6277,4308.62427771094,1133,1384,1398,1436.0301397185,3.00037175999352,1.58514126841129,{"v":7.41119398641797e-10,"d":"7.41E-10"},{"v":1.02149166969319e-07,"d":"1.02E-07"},"up","yes","ZFP36","protein_coding","chrNC_037345.1:49101950-49104263:+","gi|27819622|ref|NP_776918.1|",963,{"v":6e-124,"d":"6.00E-124"},"tristetraprolin [Bos taurus]","gi|111307029|gb|BC120043.1|",1441,0,"Bos taurus zinc finger protein 36, C3H type, homolog (mouse), mRNA (cDNA clone MGC:140545 IMAGE:8271704), complete cds","P53781",375,{"v":2e-125,"d":"2.00E-125"},"mRNA decay activator protein ZFP36","ECU01g0830",100,{"v":2e-22,"d":"2.00E-22"},"COG5063","pfam00642","zf-CCCH","Zinc finger C-x8-C-x5-C-x3-H type (and similar).","GO:0061158|3'-UTR-mediated mRNA destabilization;GO:0070935|3'-UTR-mediated mRNA stabilization;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0071385|cellular response to glucocorticoid stimulus;GO:0097011|cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:0071222|cellular response to lipopolysaccharide;GO:0071356|cellular response to tumor necrosis factor;GO:0000165|MAPK cascade;GO:0035278|negative regulation of translation involved in gene silencing by miRNA;GO:0006402|mRNA catabolic process;GO:0051028|mRNA transport;GO:0007275|multicellular organismal development;GO:0045647|negative regulation of erythrocyte differentiation;GO:0045085|negative regulation of interleukin-2 biosynthetic process;GO:1904246|negative regulation of polynucleotide adenylyltransferase activity;GO:0032897|negative regulation of viral transcription;GO:0031086|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay;GO:0038066|p38MAPK cascade;GO:1901835|positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA;GO:0045600|positive regulation of fat cell differentiation;GO:2000637|positive regulation of gene silencing by miRNA;GO:1904582|positive regulation of intracellular mRNA localization;GO:0061014|positive regulation of mRNA catabolic process;GO:1900153|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;GO:0060213|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:1902172|regulation of keratinocyte apoptotic process;GO:0045616|regulation of keratinocyte differentiation;GO:0010837|regulation of keratinocyte proliferation;GO:0043488|regulation of mRNA stability;GO:0032680|regulation of tumor necrosis factor production;GO:0042594|response to starvation;GO:0009611|response to wounding;","GO:0005737|cytoplasm;GO:0010494|cytoplasmic stress granule;GO:0005829|cytosol;GO:0005634|nucleus;GO:0000932|cytoplasmic mRNA processing body;","GO:0071889|14-3-3 protein binding;GO:0017091|AU-rich element binding;GO:0003677|DNA binding;GO:0031072|heat shock protein binding;GO:0046872|metal ion binding;GO:0035925|mRNA 3'-UTR AU-rich region binding;GO:0003730|mRNA 3'-UTR binding;GO:0003729|mRNA binding;GO:0070063|RNA polymerase binding;","K15308","TTP; tristetraprolin"]
["gene22668",268,302,515,326.985407900668,170,94,142,149.295556976798,2.19018847259791,1.13105502360851,0.00371533665686077,0.0482926059940294,"up","yes","NUMBL","protein_coding","chrNC_037345.1:49949050-49973876:-","gi|296477808|tpg|DAA19923.1|",2132,0,"TPA: numb homolog-like [Bos taurus]","gi|116003888|ref|NM_001076834.1|",3140,0,"Bos taurus numb homolog (Drosophila)-like (NUMBL), mRNA","O08919",775,0,"Numb-like protein",".",".",".",".","pfam06311","NumbF","NUMB domain. This presumed domain is found in the Numb family of proteins adjacent to the PTB domain..","GO:0034332|adherens junction organization;GO:0007409|axonogenesis;GO:0019221|cytokine-mediated signaling pathway;GO:0030900|forebrain development;GO:0021670|lateral ventricle development;GO:0007399|nervous system development;GO:0021849|neuroblast division in subventricular zone;GO:0007405|neuroblast proliferation;GO:0050775|positive regulation of dendrite morphogenesis;GO:0050769|positive regulation of neurogenesis;GO:0019538|protein metabolic process;","GO:0005737|cytoplasm;",".","K06057","NUMBL; numb"]
["gene22714",195,326,165,208.332564149747,40,48,52,51.3367171184573,4.05815906905438,2.02082541601576,{"v":4.26121939710745e-08,"d":"4.26E-08"},{"v":3.93452590999588e-06,"d":"3.93E-06"},"up","yes","TMEM145","protein_coding","chrNC_037345.1:50963256-50973116:-","gi|989881601|ref|XP_015441694.1|",2278,0,"PREDICTED: transmembrane protein 145 [Pteropus alecto]","gi|160333826|ref|NM_001110441.1|",2132,0,"Bos taurus transmembrane protein 145 (TMEM145), mRNA","Q8C4U2",800,0,"Transmembrane protein 145",".",".",".",".","pfam10192","GpcrRhopsn4","Rhodopsin-like GPCR transmembrane domain. This region of 270 amino acids is the seven transmembrane alpha-helical domains included within five GPCRRHODOPSN4 motifs of a G-protein-coupled-receptor (GPCR) protein, conserved from nematodes to humans. GPCRs are integral membrane receptors whose intracellular actions are mediated by signalling pathways involving G proteins and downstream secondary messengers.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0019236|response to pheromone;","GO:0016021|integral component of membrane;",".",".","."]
["gene2272",2514,5874,4548,3977.0096547154,1583,1729,1791,1872.69883676518,2.12367817859337,1.08656515723208,{"v":3.24974746886912e-05,"d":"3.25E-05"},0.00113486591229259,"up","yes","ATG9A","protein_coding","chrNC_037329.1:107170282-107179778:-","gi|533163665|ref|XP_005395608.1|",3976,0,"PREDICTED: autophagy-related protein 9A isoform X3 [Chinchilla lanigera]","gi|982914760|ref|XM_010802364.2|",3978,0,"PREDICTED: Bos taurus autophagy related 9A (ATG9A), transcript variant X1, mRNA","Q3T904",1527,0,"Autophagy-related protein 9A",".",".",".",".","pfam04109","APG9","Autophagy protein Apg9. In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles, possibly serving as a marker for a specialized compartment essential for these vesicle-mediated alternative targeting pathways.","GO:0000422|mitophagy;GO:0044805|late nucleophagy;GO:0034497|protein localization to pre-autophagosomal structure;GO:0015031|protein transport;","GO:0005776|autophagosome;GO:0000421|autophagosome membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0031902|late endosome membrane;GO:0000407|pre-autophagosomal structure;",".","K17907","ATG9; autophagy-related protein 9"]
["gene22788",3331,2591,3147,2683.7642896904,1288,744,1045,1131.66871991992,2.37151053347158,1.24580627640962,0.000387011751678096,0.00859955785601851,"up","yes","PVR","protein_coding","chrNC_037345.1:52420902-52439151:+","gi|942068074|ref|XP_014335114.1|",2079,0,"PREDICTED: poliovirus receptor [Bos mutus]","gi|982953932|ref|XM_005219427.3|",3144,0,"PREDICTED: Bos taurus poliovirus receptor (LOC526865), transcript variant X1, mRNA","P15151",371,{"v":5e-116,"d":"5.00E-116"},"Poliovirus receptor",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0034332|adherens junction organization;GO:0008037|cell recognition;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0002860|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0050776|regulation of immune response;GO:0042271|susceptibility to natural killer cell mediated cytotoxicity;GO:0060370|susceptibility to T cell mediated cytotoxicity;","GO:0009986|cell surface;GO:0005913|cell-cell adherens junction;GO:0005737|cytoplasm;GO:0005615|extracellular space;GO:0005925|focal adhesion;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0050839|cell adhesion molecule binding;GO:0042803|protein homodimerization activity;GO:0038023|signaling receptor activity;GO:0005102|receptor binding;GO:0001618|virus receptor activity;","K06539","PVR, NECL5; poliovirus receptor"]
["gene22798",3854,6745,5613,4938.77143045749,1565,1098,1527,1539.10501255785,3.20885929820325,1.6820605318339,{"v":1.42305845084985e-10,"d":"1.42E-10"},{"v":2.24316467741421e-08,"d":"2.24E-08"},"up","yes","BCAM","protein_coding","chrNC_037345.1:52563039-52574351:+","gi|555976888|ref|XP_005900403.1|",2651,0,"PREDICTED: basal cell adhesion molecule [Bos mutus]","gi|133778182|gb|BC123496.1|",2357,0,"Bos taurus basal cell adhesion molecule (Lutheran blood group), mRNA (cDNA clone MGC:139914 IMAGE:8284754), complete cds","Q9MZ08",1025,0,"Basal cell adhesion molecule",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0007160|cell-matrix adhesion;","GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0043236|laminin binding;GO:0005055|laminin receptor activity;GO:0008022|protein C-terminus binding;","K06578","LU; Lutheran blood group glycoprotein"]
["gene2285",11906,35011,18616,20294.0802557223,6934,7003,7669,7930.02296452297,2.55914520632704,1.3556620084577,{"v":1.20991891963996e-05,"d":"1.21E-05"},0.000503944477317485,"up","yes","SPEG","protein_coding","chrNC_037329.1:107365755-107423523:+","gi|296490300|tpg|DAA32413.1|",13873,0,"TPA: SPEG complex locus [Bos taurus]","gi|215599779|ref|NM_001142485.1|",9968,0,"Bos taurus SPEG complex locus (SPEG), mRNA","Q15772",4865,0,"Striated muscle preferentially expressed protein kinase",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0042692|muscle cell differentiation;GO:0007517|muscle organ development;GO:0008285|negative regulation of cell proliferation;","GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0004674|protein serine/threonine kinase activity;","K08809","SPEG; striated muscle-specific serine/threonine protein kinase [EC:2.7.11.1]"]
["gene22855",232,58,57,96.9781494556452,22,27,24,26.7949116696602,3.61927483289498,1.85570066421777,{"v":8.16304204410255e-05,"d":"8.16E-05"},0.00245922017185198,"up","yes","NOVA2","protein_coding","chrNC_037345.1:53442851-53469024:-","gi|918661131|ref|XP_013365025.1|",1303,{"v":2e-174,"d":"2.00E-174"},"PREDICTED: RNA-binding protein Nova-2, partial [Chinchilla lanigera]","gi|329663501|ref|NM_001206109.1|",1641,0,"Bos taurus neuro-oncological ventral antigen 2 (NOVA2), mRNA","Q9UNW9",501,{"v":2e-171,"d":"2.00E-171"},"RNA-binding protein Nova-2",".",".",".",".","pfam00013","KH_1","KH domain. KH motifs bind RNA in vitro. Autoantibodies to Nova, a KH domain protein, cause paraneoplastic opsoclonus ataxia.","GO:0000398|mRNA splicing, via spliceosome;GO:0051252|regulation of RNA metabolic process;","GO:0005634|nucleus;","GO:0003723|RNA binding;","K14944","NOVA; RNA-binding protein Nova"]
["gene2286",218,652,299,362.317160921814,112,88,108,113.142004124728,3.20232228273413,1.67911850844907,{"v":2.38230560186579e-07,"d":"2.38E-07"},{"v":1.76086945924437e-05,"d":"1.76E-05"},"up","yes","LOC513894","protein_coding","chrNC_037329.1:107423764-107428876:+","gi|982914801|ref|XP_015314773.1|",1132,{"v":1e-152,"d":"1.00E-152"},"PREDICTED: LOW QUALITY PROTEIN: CAVP-target protein [Bos taurus]","gi|982914800|ref|XM_015459287.1|",915,0,"PREDICTED: Bos taurus CAVP-target protein (LOC513894), mRNA",".",".",".",".",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.",".",".",".",".","."]
["gene22870",7953,27749,27650,19658.4876521261,4758,5424,5515,5759.69462711805,3.41311283406747,1.77108810926795,{"v":3.47706830372891e-09,"d":"3.48E-09"},{"v":4.06574736777417e-07,"d":"4.07E-07"},"up","yes","CALM3","protein_coding","chrNC_037345.1:53737061-53746135:+","gi|744616901|ref|XP_010996006.1|",793,{"v":1e-97,"d":"1.00E-97"},"PREDICTED: calmodulin [Camelus dromedarius]","gi|402693480|ref|NM_001046249.2|",2076,0,"Bos taurus calmodulin 3 (phosphorylase kinase, delta) (CALM3), mRNA","P0DP35",300,{"v":4e-96,"d":"4.00E-96"},"Calmodulin-2 B","SPAC3A12.14",233,{"v":2e-71,"d":"2.00E-71"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.",".",".","GO:0005509|calcium ion binding;GO:0005102|receptor binding;","K02183","CALM; calmodulin"]
["gene22874",1310,438,664,688.885548463704,275,231,265,283.218168677514,2.43234942052076,1.28235049483489,{"v":3.30155428770974e-06,"d":"3.30E-06"},0.000166131649704844,"up","yes","PRKD2","protein_coding","chrNC_037345.1:53789608-53823615:-","gi|983000223|ref|XP_001251452.5|",4064,0,"PREDICTED: serine/threonine-protein kinase D2 isoform X2 [Bos taurus]","gi|742174109|ref|XM_010852641.1|",3884,0,"PREDICTED: Bison bison bison protein kinase D2 (PRKD2), transcript variant X2, mRNA","Q9BZL6",1520,0,"Serine/threonine-protein kinase D2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0002250|adaptive immune response;GO:0001525|angiogenesis;GO:0007155|cell adhesion;GO:0008219|cell death;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0061154|endothelial tube morphogenesis;GO:0035556|intracellular signal transduction;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;GO:0045766|positive regulation of angiogenesis;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0045785|positive regulation of cell adhesion;GO:0032793|positive regulation of CREB transcription factor activity;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:2000573|positive regulation of DNA biosynthetic process;GO:2001028|positive regulation of endothelial cell chemotaxis;GO:0038033|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0010595|positive regulation of endothelial cell migration;GO:0001938|positive regulation of endothelial cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0045743|positive regulation of fibroblast growth factor receptor signaling pathway;GO:1901727|positive regulation of histone deacetylase activity;GO:0032743|positive regulation of interleukin-2 production;GO:0032757|positive regulation of interleukin-8 production;GO:1902533|positive regulation of intracellular signal transduction;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0046777|protein autophosphorylation;GO:0089700|protein kinase D signaling;GO:0006468|protein phosphorylation;GO:0030148|sphingolipid biosynthetic process;GO:0050852|T cell receptor signaling pathway;GO:0048010|vascular endothelial growth factor receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005794|Golgi apparatus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004672|protein kinase activity;GO:0004697|protein kinase C activity;GO:0005080|protein kinase C binding;GO:0004674|protein serine/threonine kinase activity;","K06070","PKD; protein kinase D [EC:2.7.11.13]"]
["gene22896",0,23,0,7.53750662175161,0,0,0,0,"Inf","Inf",0.00296743973843368,0.0409876098953687,"up","yes","ZNF541","protein_coding","chrNC_037345.1:54493525-54519869:-","gi|982954057|ref|XP_015313711.1|",6617,0,"PREDICTED: zinc finger protein 541 [Bos taurus]","gi|983000238|ref|XM_015467604.1|",4628,0,"PREDICTED: Bos taurus zinc finger protein 541 (ZNF541), mRNA","Q9H0D2",1815,0,"Zinc finger protein 541",".",".",".",".","pfam01448","ELM2","ELM2 domain. The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in a member from Arabidopsis thaliana. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.","GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;","GO:0000118|histone deacetylase complex;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0044212|transcription regulatory region DNA binding;",".","."]
["gene229",7865,3262,4501,4501.17130015877,1506,2124,1752,1974.80084092209,2.27930392112707,1.18859330559012,{"v":1.67267391910425e-06,"d":"1.67E-06"},{"v":9.52556079560146e-05,"d":"9.53E-05"},"up","yes","CRYBG3","protein_coding","chrNC_037328.1:42070464-42197661:+","gi|528936049|ref|XP_002684727.2|",14901,0,"PREDICTED: very large A-kinase anchor protein [Bos taurus]","gi|982975270|ref|XM_594681.8|",10405,0,"PREDICTED: Bos taurus crystallin beta-gamma domain containing 3 (CRYBG3), mRNA","Q68DQ2",3836,0,"Very large A-kinase anchor protein",".",".",".",".","pfam00030","Crystall","Beta/Gamma crystallin. The alignment comprises two Greek key motifs since the similarity between them is very low.",".","GO:0032991|macromolecular complex;","GO:0030246|carbohydrate binding;GO:0051018|protein kinase A binding;",".","."]
["gene22925",990,1496,1089,1082.73811156013,354,545,501,513.16954613977,2.10990328577531,1.07717686986603,0.000140246410880166,0.00385860207215237,"up","yes","TMEM143","protein_coding","chrNC_037345.1:55044411-55064757:-","gi|982953410|ref|XP_005219261.2|",2156,0,"PREDICTED: transmembrane protein 143 isoform X2 [Bos taurus]","gi|402692976|ref|NM_001037447.2|",2241,0,"Bos taurus transmembrane protein 143 (TMEM143), mRNA","Q32PH2",821,0,"Transmembrane protein 143",".",".",".",".","pfam08347","CTNNB1_binding","N-terminal CTNNB1 binding. This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.",".","GO:0016021|integral component of membrane;GO:0005739|mitochondrion;",".",".","."]
["gene22941",98,91,222,123.544388678747,14,16,24,19.7679036892973,6.24974659025864,2.64379769371249,{"v":5.65973803210593e-09,"d":"5.66E-09"},{"v":6.21069176130824e-07,"d":"6.21E-07"},"up","yes","CA11","protein_coding","chrNC_037345.1:55279505-55285895:-","gi|742163150|ref|XP_010847860.1|",1960,0,"PREDICTED: carbonic anhydrase-related protein 11 isoform X1 [Bison bison bison]","gi|742163149|ref|XM_010849558.1|",1718,0,"PREDICTED: Bison bison bison carbonic anhydrase XI (CA11), transcript variant X1, mRNA","Q866X7",620,0,"Carbonic anhydrase-related protein 11","all2929",77.8,{"v":6e-15,"d":"6.00E-15"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.",".","GO:0005576|extracellular region;","GO:0008270|zinc ion binding;",".","."]
["gene22958",179,408,297,271.575497691577,78,116,73,98.0754898942831,2.76904553812896,1.46938877963211,{"v":4.63794944154465e-05,"d":"4.64E-05"},0.00150896143680993,"up","yes","DHDH","protein_coding","chrNC_037345.1:55510391-55521357:+","gi|115498004|ref|NP_001069937.1|",1693,0,"trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [Bos taurus]","gi|115498003|ref|NM_001076469.1|",1229,0,"Bos taurus dihydrodiol dehydrogenase (dimeric) (DHDH), mRNA","Q148L6",656,0,"Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase","CAC1480",179,{"v":3e-51,"d":"3.00E-51"},"COG0673","pfam01408","GFO_IDH_MocA","Oxidoreductase family, NAD-binding Rossmann fold. This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.","GO:0042843|D-xylose catabolic process;",".","GO:0047837|D-xylose 1-dehydrogenase (NADP+) activity;GO:0047115|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity;","K00078","DHDH; dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) [EC:1.3.1.20 1.1.1.179]"]
["gene22963",126,115,137,112.601724754431,18,21,19,21.2930494527178,5.2881915765268,2.40277444263583,{"v":1.55879940322257e-07,"d":"1.56E-07"},{"v":1.23539182703731e-05,"d":"1.24E-05"},"up","yes","LHB","protein_coding","chrNC_037345.1:55571842-55577814:-","gi|741894747|ref|XP_010822113.1|",1767,0,"PREDICTED: uncharacterized protein LOC104968448 [Bos taurus]","gi|965824725|ref|XM_012127816.2|",2258,0,"PREDICTED: Ovis aries musimon uncharacterized LOC105602076 (LOC105602076), transcript variant X2, mRNA","P04651",242,{"v":7e-72,"d":"7.00E-72"},"Lutropin subunit beta",".",".",".",".","pfam00007","Cys_knot","Cystine-knot domain. The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.","GO:0007267|cell-cell signaling;GO:0007186|G-protein coupled receptor signaling pathway;GO:0009755|hormone-mediated signaling pathway;GO:0030728|ovulation;","GO:0005737|cytoplasm;GO:0005615|extracellular space;","GO:0005179|hormone activity;","K08521","LHB; luteinizing hormone beta polypeptide"]
["gene23041",62643,302075,172813,168396.150240179,13725,41582,25695,29665.2425003126,5.67654723329514,2.50501367549879,0.000359335392356019,0.00811091620198543,"up","yes","MYBPC2","protein_coding","chrNC_037345.1:56581619-56607293:+","gi|440898033|gb|ELR49615.1|",3645,0,"Myosin-binding protein C, fast-type, partial [Bos mutus]","gi|942082483|ref|XM_005905040.2|",2279,0,"PREDICTED: Bos mutus myosin binding protein C, fast type (MYBPC2), transcript variant X2, mRNA","Q14324",1285,0,"Myosin-binding protein C, fast-type",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007015|actin filament organization;GO:0007155|cell adhesion;GO:0030049|muscle filament sliding;GO:0045214|sarcomere organization;GO:0006941|striated muscle contraction;GO:0071688|striated muscle myosin thick filament assembly;","GO:0005829|cytosol;GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0032982|myosin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0051371|muscle alpha-actinin binding;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;","K12558","MYBPC2; myosin-binding protein C, fast-type"]
["gene23067",69,203,162,134.263396865149,20,9,25,19.8025721359337,6.78009886511232,2.76130631040695,{"v":8.02792025327374e-07,"d":"8.03E-07"},{"v":5.0009736407457e-05,"d":"5.00E-05"},"up","yes","KLK7","protein_coding","chrNC_037345.1:56960737-56965958:-","gi|115497400|ref|NP_001068724.1|",1340,0,"kallikrein-7 precursor [Bos taurus]","gi|115497399|ref|NM_001075256.1|",1488,0,"Bos taurus kallikrein related peptidase 7 (KLK7), mRNA","P49862",382,{"v":7e-129,"d":"7.00E-129"},"Kallikrein-7","mlr3307",111,{"v":2e-26,"d":"2.00E-26"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0008544|epidermis development;GO:0022617|extracellular matrix disassembly;GO:0002803|positive regulation of antibacterial peptide production;","GO:0097209|epidermal lamellar body;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0004222|metalloendopeptidase activity;GO:0008233|peptidase activity;GO:0004252|serine-type endopeptidase activity;GO:0008236|serine-type peptidase activity;","K08668","KLK7, PRSS6; kallikrein 7 (chymotryptic, stratum corneum) [EC:3.4.21.117]"]
["gene2320",0,0,44,13.5133518787565,0,0,0,0,"Inf","Inf",{"v":7.06005609172091e-05,"d":"7.06E-05"},0.00217500715007672,"up","yes","SCG2","protein_coding","chrNC_037329.1:111768888-111774396:-","gi|741917812|ref|XP_010800694.1|",3359,0,"PREDICTED: secretogranin-2 isoform X1 [Bos taurus]","gi|982914843|ref|XM_010802392.2|",2448,0,"PREDICTED: Bos taurus secretogranin II (SCG2), transcript variant X1, mRNA","P20616",1244,0,"Secretogranin-2",".",".",".",".","pfam01271","Granin","Granin (chromogranin or secretogranin).","GO:0001525|angiogenesis;GO:0048245|eosinophil chemotaxis;GO:0050930|induction of positive chemotaxis;GO:0035556|intracellular signal transduction;GO:0000165|MAPK cascade;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:0050918|positive chemotaxis;GO:0001938|positive regulation of endothelial cell proliferation;","GO:0005615|extracellular space;","GO:0042056|chemoattractant activity;GO:0005125|cytokine activity;",".","."]
["gene23293",127,465,381,302.501214313951,98,112,163,136.570461382815,2.21498273675756,1.14729545467586,0.00186040056183696,0.0292124867527629,"up","yes","ZNF524","protein_coding","chrNC_037345.1:61938870-61942474:-","gi|545832865|ref|XP_005664903.1|",896,{"v":5e-113,"d":"5.00E-113"},"PREDICTED: zinc finger protein 524-like isoform X1 [Sus scrofa]","gi|329664433|ref|NM_001205463.1|",1433,0,"Bos taurus zinc finger protein 524 (ZNF524), mRNA","Q96C55",259,{"v":5e-81,"d":"5.00E-81"},"Zinc finger protein 524",".",".",".",".","pfam00096","zf-C2H2","Zinc finger, C2H2 type. The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["gene23299",583,1166,928,819.071037018716,216,314,374,330.971864424133,2.47474521269002,1.30728000021849,0.000146436809493964,0.00400190480045238,"up","yes","SBK2","protein_coding","chrNC_037345.1:61985271-61990222:+","gi|803321682|ref|XP_012019057.1|",1472,0,"PREDICTED: serine/threonine-protein kinase SBK2-like [Ovis aries musimon]","gi|983000768|ref|XM_866844.6|",1685,0,"PREDICTED: Bos taurus SH3 domain binding kinase family member 2 (SBK2), transcript variant X1, mRNA","P0C5K1",434,{"v":9e-147,"d":"9.00E-147"},"Serine/threonine-protein kinase SBK2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0030036|actin cytoskeleton organization;GO:0032147|activation of protein kinase activity;GO:0016477|cell migration;GO:0042981|regulation of apoptotic process;GO:0043408|regulation of MAPK cascade;GO:0007346|regulation of mitotic cell cycle;GO:0007266|Rho protein signal transduction;GO:0023014|signal transduction by protein phosphorylation;GO:0031098|stress-activated protein kinase signaling cascade;","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0004674|protein serine/threonine kinase activity;GO:0048365|Rac GTPase binding;","K08858","SBK; serine/threonine-protein kinase SBK [EC:2.7.11.1]"]
["gene23300",341,354,438,339.40385772063,94,125,146,133.709688315233,2.53836398840788,1.34389895909987,{"v":2.04620590087016e-05,"d":"2.05E-05"},0.000776333784012321,"up","yes","SSC5D","protein_coding","chrNC_037345.1:61998326-62021017:-","gi|983000771|ref|XP_015323277.1|",4986,0,"PREDICTED: soluble scavenger receptor cysteine-rich domain-containing protein SSC5D isoform X2 [Bos taurus]","gi|983000770|ref|XM_015467791.1|",5062,0,"PREDICTED: Bos taurus scavenger receptor cysteine rich family, 5 domains (SSC5D), transcript variant X2, mRNA","A1L4H1",1346,0,"Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0042494|detection of bacterial lipoprotein;GO:0045087|innate immune response;GO:0007275|multicellular organismal development;GO:2000483|negative regulation of interleukin-8 secretion;","GO:0005737|cytoplasm;GO:0031012|extracellular matrix;GO:0005615|extracellular space;GO:0005622|intracellular;GO:0016020|membrane;","GO:0050840|extracellular matrix binding;GO:0001968|fibronectin binding;GO:0043236|laminin binding;GO:0005044|scavenger receptor activity;",".","."]
["gene23305",416,700,599,521.787500499731,199,112,205,189.481899806524,2.75375907161854,1.46140234255712,0.000220856310529663,0.00544149516038155,"up","yes","ISOC2","protein_coding","chrNC_037345.1:62053772-62060244:+","gi|528993427|ref|XP_005219752.1|",1044,{"v":7e-140,"d":"7.00E-140"},"PREDICTED: isochorismatase domain-containing protein 2 isoform X2 [Bos taurus]","gi|982955038|ref|XM_005219695.3|",1053,0,"PREDICTED: Bos taurus isochorismatase domain containing 2 (ISOC2), transcript variant X4, mRNA","Q32KX0",405,{"v":6e-141,"d":"6.00E-141"},"Isochorismatase domain-containing protein 2","AF2335",95.1,{"v":2e-22,"d":"2.00E-22"},"COG1335","pfam00857","Isochorismatase","Isochorismatase family. This family are hydrolase enzymes.","GO:0008152|metabolic process;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003824|catalytic activity;",".","."]
["gene23313",0,24,0,7.8652243009582,0,0,0,0,"Inf","Inf",0.00240574017807166,0.035199063087468,"up","yes","FAM71E2","protein_coding","chrNC_037345.1:62117538-62124492:+","gi|296477230|tpg|DAA19345.1|",4009,0,"TPA: hypothetical protein BOS_18080 [Bos taurus]","gi|965904313|ref|XM_015090081.1|",2548,0,"PREDICTED: Ovis aries musimon family with sequence similarity 71 member E2 (FAM71E2), transcript variant X2, mRNA","Q8N5Q1",668,0,"Protein FAM71E2",".",".",".",".","pfam12480","DUF3699","Protein of unknown function (DUF3699). This domain family is found in eukaryotes, and is approximately 80 amino acids in length.",".","GO:0005634|nucleus;",".",".","."]
["gene23377",622,466,745,543.629708860431,177,244,269,252.803625790071,2.15040313271401,1.10460714495349,0.000100392108808306,0.00290201343101293,"up","yes","NDUFA3","protein_coding","chrNC_037345.1:63279553-63282870:-","gi|556775029|ref|XP_005982639.1|",460,{"v":7e-57,"d":"7.00E-57"},"PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like, partial [Pantholops hodgsonii]","gi|74268253|gb|BC102727.1|",328,{"v":4e-170,"d":"4.00E-170"},"Bos taurus NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa, mRNA (cDNA clone MGC:127829 IMAGE:30957575), complete cds","Q02371",172,{"v":4e-55,"d":"4.00E-55"},"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3",".",".",".",".","pfam14987","NADHdh_A3","NADH dehydrogenase 1 alpha subcomplex subunit 3. This family of proteins are accessory subunits of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). This subunit is not believed to be catalytic.","GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0055114|oxidation-reduction process;","GO:0016021|integral component of membrane;GO:0005747|mitochondrial respiratory chain complex I;",".","K03947","NDUFA3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3"]
["gene2340",2562,6023,6712,4702.96071941325,1157,1280,1380,1400.33635471587,3.35845077761156,1.74779588452694,{"v":9.38688730223596e-12,"d":"9.39E-12"},{"v":1.89941334482336e-09,"d":"1.90E-09"},"up","yes","IRS1","protein_coding","chrNC_037329.1:114924912-114993390:-","gi|358411068|ref|XP_003581919.1|",4881,0,"PREDICTED: insulin receptor substrate 1 [Bos taurus]","gi|594102165|ref|XM_006074094.1|",8273,0,"PREDICTED: Bubalus bubalis insulin receptor substrate 1 (IRS1), mRNA","Q28224",1699,0,"Insulin receptor substrate 1",".",".",".",".","pfam02174","IRS","PTB domain (IRS-1 type).","GO:0048009|insulin-like growth factor receptor signaling pathway;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;GO:0005634|nucleus;","GO:0005158|insulin receptor binding;GO:0005159|insulin-like growth factor receptor binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0042169|SH2 domain binding;",".","."]
["gene23554",966,2526,2452,1832.6391500667,390,477,405,467.016645403633,3.92414096607367,1.97237686811233,{"v":1.12842027812239e-14,"d":"1.13E-14"},{"v":3.70056999484022e-12,"d":"3.70E-12"},"up","yes","HLF","protein_coding","chrNC_037346.1:5491508-5545760:+","gi|926715597|ref|XP_013827229.1|",1163,{"v":2e-142,"d":"2.00E-142"},"PREDICTED: hepatic leukemia factor [Capra hircus]","gi|742139083|ref|XM_010843687.1|",4353,0,"PREDICTED: Bison bison bison hepatic leukemia factor (HLF), mRNA","Q16534",441,{"v":9e-140,"d":"9.00E-140"},"Hepatic leukemia factor",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0007275|multicellular organismal development;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0048511|rhythmic process;GO:0035914|skeletal muscle cell differentiation;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003690|double-stranded DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09057","HLF; hepatic leukemia factor"]
["gene23562",404,139,104,182.785194986788,59,78,58,71.6137752323728,2.55237479652043,1.35184019327965,0.000307839983668557,0.00716393358405187,"up","yes","LOC513767","protein_coding","chrNC_037346.1:6107084-6131543:-","gi|594073558|ref|XP_006060595.1|",1258,{"v":3e-169,"d":"3.00E-169"},"PREDICTED: phosphatidylcholine transfer protein-like [Bubalus bubalis]","gi|402692978|ref|NM_001083681.2|",1502,0,"Bos taurus phosphatidylcholine transfer protein-like (LOC513767), mRNA","P02720",269,{"v":1e-85,"d":"1.00E-85"},"Phosphatidylcholine transfer protein",".",".",".",".","pfam01852","START","START domain.","GO:0015914|phospholipid transport;","GO:0005829|cytosol;","GO:0031210|phosphatidylcholine binding;GO:0008525|phosphatidylcholine transporter activity;",".","."]
["gene23594",5558,6681,7207,5851.45137852849,2646,2351,2816,2868.27779520772,2.04005741295526,1.02860975426554,{"v":6.61346652058901e-05,"d":"6.61E-05"},0.00205767517228926,"up","yes","CUEDC1","protein_coding","chrNC_037346.1:8670137-8758964:-","gi|528994043|ref|XP_005219965.1|",1650,0,"PREDICTED: CUE domain-containing protein 1 isoform X1 [Bos taurus]","gi|982955905|ref|XM_005219908.3|",3315,0,"PREDICTED: Bos taurus CUE domain containing 1 (CUEDC1), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam02845","CUE","CUE domain. CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.",".",".",".",".","."]
["gene23773",574,37,213,227.140200033155,22,38,21,29.7488562631844,7.63525824400353,2.93267695349135,{"v":1.0776828674969e-10,"d":"1.08E-10"},{"v":1.7371395419522e-08,"d":"1.74E-08"},"up","yes","CCL1","protein_coding","chrNC_037346.1:15783121-15786651:+","gi|556755465|ref|XP_005973086.1|",480,{"v":2e-53,"d":"2.00E-53"},"PREDICTED: uncharacterized protein LOC102325381 [Pantholops hodgsonii]","gi|983001337|ref|XM_001253011.5|",1030,0,"PREDICTED: Bos taurus chemokine (C-C motif) ligand 1 (CCL1), mRNA","P22362",75.5,{"v":1e-15,"d":"1.00E-15"},"C-C motif chemokine 1",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0006874|cellular calcium ion homeostasis;GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0070098|chemokine-mediated signaling pathway;GO:0006935|chemotaxis;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006954|inflammatory response;GO:0031640|killing of cells of other organism;GO:0048247|lymphocyte chemotaxis;GO:0030593|neutrophil chemotaxis;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0043547|positive regulation of GTPase activity;GO:0090026|positive regulation of monocyte chemotaxis;GO:0007165|signal transduction;GO:0016032|viral process;","GO:0005623|cell;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0048020|CCR chemokine receptor binding;GO:0008009|chemokine activity;","K05514","CCLX; C-C motif chemokine, other"]
["gene23832",172,20,33,61.5165642290276,15,6,11,11.7791485396956,5.22249668740634,2.38473967220115,{"v":4.06878128321225e-05,"d":"4.07E-05"},0.00135932551277902,"up","yes","NOS2","protein_coding","chrNC_037346.1:19388579-19431368:-","gi|116003827|ref|NP_001070267.1|",6028,0,"nitric oxide synthase, inducible [Bos taurus]","gi|555969444|ref|XM_005896685.1|",4100,0,"PREDICTED: Bos mutus nitric oxide synthase 2, inducible (NOS2), transcript variant X1, mRNA","Q27995",2322,0,"Nitric oxide synthase, inducible","BH0823",351,{"v":6e-108,"d":"6.00E-108"},"COG4362","pfam02898","NO_synthase","Nitric oxide synthase, oxygenase domain.","GO:0042742|defense response to bacterium;GO:0006954|inflammatory response;GO:0072604|interleukin-6 secretion;GO:0072606|interleukin-8 secretion;GO:0045776|negative regulation of blood pressure;GO:0006809|nitric oxide biosynthetic process;GO:0007263|nitric oxide mediated signal transduction;GO:0018119|peptidyl-cysteine S-nitrosylation;GO:0031284|positive regulation of guanylate cyclase activity;GO:0032310|prostaglandin secretion;GO:1900015|regulation of cytokine production involved in inflammatory response;","GO:0005622|intracellular;","GO:0005516|calmodulin binding;GO:0050660|flavin adenine dinucleotide binding;GO:0010181|FMN binding;GO:0020037|heme binding;GO:0046872|metal ion binding;GO:0050661|NADP binding;GO:0003958|NADPH-hemoprotein reductase activity;GO:0004517|nitric-oxide synthase activity;","K13241","NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]"]
["gene23943",3875,7281,11234,6846.23189699693,1072,2583,1861,2020.37882878941,3.38858821892284,1.76068433124137,0.00112597418839638,0.01978150835538,"up","yes","SLC43A2","protein_coding","chrNC_037346.1:22686350-22730446:-","gi|115495725|ref|NP_001069014.1|",2751,0,"large neutral amino acids transporter small subunit 4 [Bos taurus]","gi|982956276|ref|XM_005220090.3|",7621,0,"PREDICTED: Bos taurus solute carrier family 43 (amino acid system L transporter), member 2 (SLC43A2), transcript variant X2, mRNA","Q0VCM6",1064,0,"Large neutral amino acids transporter small subunit 4",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.",".","GO:0005887|integral component of plasma membrane;","GO:0015179|L-amino acid transmembrane transporter activity;GO:0015175|neutral amino acid transmembrane transporter activity;","K08229","SLC43A2; MFS transporter, LAT3 family, solute carrier family 43, member 2"]
["gene23957",218,490,133,258.244705711402,15,24,14,19.4678434468653,13.2651932617109,3.72957378935189,{"v":2.46211084495947e-21,"d":"2.46E-21"},{"v":2.00704241478682e-18,"d":"2.01E-18"},"up","yes","RTN4RL1","protein_coding","chrNC_037346.1:22977123-23051914:-","gi|528920876|ref|XP_005195677.1|",2293,0,"PREDICTED: reticulon-4 receptor-like 1 [Bos taurus]","gi|983001498|ref|XM_005195620.3|",3547,0,"PREDICTED: Bos taurus reticulon 4 receptor-like 1 (RTN4RL1), mRNA","Q80WD0",807,0,"Reticulon-4 receptor-like 1","SPy1798",70.1,{"v":4e-11,"d":"4.00E-11"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007166|cell surface receptor signaling pathway;GO:0022038|corpus callosum development;GO:0019221|cytokine-mediated signaling pathway;GO:0048681|negative regulation of axon regeneration;GO:0046426|negative regulation of JAK-STAT cascade;GO:0010977|negative regulation of neuron projection development;GO:0006469|negative regulation of protein kinase activity;","GO:0046658|anchored component of plasma membrane;GO:0042995|cell projection;GO:0009986|cell surface;GO:0005737|cytoplasm;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0045121|membrane raft;GO:0043204|perikaryon;","GO:0035374|chondroitin sulfate binding;GO:0008201|heparin binding;GO:0004860|protein kinase inhibitor activity;GO:0038023|signaling receptor activity;","K16660","RTN4RL1, NGR3; reticulon-4 receptor-like 1"]
["gene23973",2176,1537,1207,1441.51404806111,309,187,318,298.910393796286,4.82256247350011,2.26979992767303,{"v":7.31183313769908e-11,"d":"7.31E-11"},{"v":1.24174947173626e-08,"d":"1.24E-08"},"up","yes","MNT","protein_coding","chrNC_037346.1:23350861-23367334:-","gi|803293699|ref|XP_012006516.1|",998,{"v":5e-116,"d":"5.00E-116"},"PREDICTED: max-binding protein MNT isoform X4 [Ovis aries musimon]","gi|982956323|ref|XM_005220126.3|",3867,0,"PREDICTED: Bos taurus MAX network transcriptional repressor (MNT), transcript variant X1, mRNA","Q99583",369,{"v":1e-110,"d":"1.00E-110"},"Max-binding protein MNT",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0007569|cell aging;GO:0007275|multicellular organismal development;GO:2001234|negative regulation of apoptotic signaling pathway;GO:0008285|negative regulation of cell proliferation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0051726|regulation of cell cycle;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046983|protein dimerization activity;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003713|transcription coactivator activity;GO:0003714|transcription corepressor activity;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09115","MNT, ROX; MAX-binding protein"]
["gene24055",557,367,393,386.138333194573,104,177,153,159.057533023706,2.42766454284829,1.27956908229999,0.000127345317216109,0.00355855949607522,"up","yes","WSCD1","protein_coding","chrNC_037346.1:25639426-25687099:-","gi|332634729|ref|NP_001193829.1|",2537,0,"WSC domain-containing protein 1 [Bos taurus]","gi|982956638|ref|XM_005220255.3|",2884,0,"PREDICTED: Bos taurus WSC domain containing 1 (WSCD1), transcript variant X1, mRNA","Q658N2",919,0,"WSC domain-containing protein 1",".",".",".",".","pfam01822","WSC","WSC domain. This domain may be involved in carbohydrate binding.",".","GO:0016021|integral component of membrane;","GO:0008146|sulfotransferase activity;",".","."]
["gene2406",49,29,112,56.6719742660729,7,1,7,5.51017441945633,10.2849692136722,3.3624655702914,{"v":3.40671211922779e-05,"d":"3.41E-05"},0.00117104702980347,"up","yes","NPPC","protein_coding","chrNC_037329.1:119585622-119590237:-","gi|440896733|gb|ELR48583.1|",403,{"v":5e-45,"d":"5.00E-45"},"C-type natriuretic peptide, partial [Bos mutus]","gi|31342793|ref|NM_174125.2|",987,0,"Bos taurus natriuretic peptide C (NPPC), mRNA","P55206",159,{"v":3e-46,"d":"3.00E-46"},"C-type natriuretic peptide",".",".",".",".","pfam00212","ANP","Atrial natriuretic peptide.","GO:0006182|cGMP biosynthetic process;GO:0003418|growth plate cartilage chondrocyte differentiation;GO:0003419|growth plate cartilage chondrocyte proliferation;GO:0051447|negative regulation of meiotic cell cycle;GO:1900194|negative regulation of oocyte maturation;GO:0001503|ossification;GO:0009791|post-embryonic development;GO:0006457|protein folding;GO:0007168|receptor guanylyl cyclase signaling pathway;GO:0050880|regulation of blood vessel size;GO:0030814|regulation of cAMP metabolic process;GO:0030823|regulation of cGMP metabolic process;GO:0040014|regulation of multicellular organism growth;GO:0022414|reproductive process;","GO:0005576|extracellular region;GO:0032991|macromolecular complex;","GO:0005179|hormone activity;GO:0051427|hormone receptor binding;GO:0005102|receptor binding;","K12336","NPPC; natriuretic peptide C"]
["gene24076",34728,90029,85025,64668.035607667,13421,29624,20229,23190.1018426352,2.78860507152988,1.47954363114325,0.00380190672650083,0.0489716482229324,"up","yes","ENO3","protein_coding","chrNC_037346.1:26439577-26446869:-","gi|958814030|ref|XP_014688104.1|",2275,0,"PREDICTED: beta-enolase isoform X1 [Equus asinus]","gi|942085672|ref|XM_005906069.2|",1638,0,"PREDICTED: Bos mutus enolase 3 (beta, muscle) (ENO3), transcript variant X1, mRNA","Q3ZC09",866,0,"Beta-enolase","YGR254w",550,0,"COG0148","pfam00113","Enolase_C","Enolase, C-terminal TIM barrel domain.","GO:0006096|glycolytic process;","GO:0000015|phosphopyruvate hydratase complex;GO:0005886|plasma membrane;","GO:0000287|magnesium ion binding;GO:0004634|phosphopyruvate hydratase activity;","K01689","ENO, eno; enolase [EC:4.2.1.11]"]
["gene24081",205,1724,2182,1288.55244703647,184,265,245,254.463392047266,5.0638028388662,2.34022123396701,{"v":1.34542388567406e-18,"d":"1.35E-18"},{"v":7.83393650656462e-16,"d":"7.83E-16"},"up","yes","CHRNE","protein_coding","chrNC_037346.1:26484698-26489336:+","gi|741962593|ref|XP_010814196.1|",2328,0,"PREDICTED: acetylcholine receptor subunit epsilon isoform X1 [Bos taurus]","gi|982956494|ref|XM_010815894.2|",1765,0,"PREDICTED: Bos taurus cholinergic receptor, nicotinic epsilon (CHRNE), transcript variant X1, mRNA","P02715",827,0,"Acetylcholine receptor subunit epsilon",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0098655|cation transmembrane transport;GO:0007274|neuromuscular synaptic transmission;GO:0035094|response to nicotine;GO:0007271|synaptic transmission, cholinergic;","GO:0005892|acetylcholine-gated channel complex;GO:0030054|cell junction;GO:0045211|postsynaptic membrane;","GO:0022848|acetylcholine-gated cation channel activity;GO:0004888|transmembrane signaling receptor activity;","K04817","CHRNE; nicotinic acetylcholine receptor epsilon"]
["gene24107",1260,359,493,597.446890617587,177,154,186,189.813994839402,3.1475386792374,1.65422410693591,{"v":1.07753037039631e-08,"d":"1.08E-08"},{"v":1.12611791200649e-06,"d":"1.13E-06"},"up","yes","BCL6B","protein_coding","chrNC_037346.1:26813286-26819327:+","gi|528994766|ref|XP_005220231.1|",1830,0,"PREDICTED: B-cell CLL/lymphoma 6 member B protein isoform X1 [Bos taurus]","gi|742155495|ref|XM_010847360.1|",3328,0,"PREDICTED: Bison bison bison B-cell CLL/lymphoma 6, member B (BCL6B), transcript variant X2, mRNA","Q8N143",613,0,"B-cell CLL/lymphoma 6 member B protein",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0045595|regulation of cell differentiation;GO:0042127|regulation of cell proliferation;GO:0050727|regulation of inflammatory response;GO:0042092|type 2 immune response;","GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;",".","."]
["gene24136",0,38,0,12.4532718098505,0,1,1,0.727960457442686,17.1070717956283,4.09652093084223,0.00211830039508637,0.0320792083716609,"up","yes","SPEM2","protein_coding","chrNC_037346.1:27102539-27105568:+","gi|555955693|ref|XP_005890002.1|",1909,0,"PREDICTED: uncharacterized protein C17orf74 homolog [Bos mutus]","gi|965814011|ref|XM_012122628.2|",2323,0,"PREDICTED: Ovis aries musimon chromosome 11 open reading frame, human C17orf74 (C11H17orf74), transcript variant X2, mRNA","Q0P670",439,{"v":3e-142,"d":"3.00E-142"},"Uncharacterized protein SPEM2",".",".",".",".","pfam09474","Type_III_YscX","Type III secretion system YscX (type_III_YscX). Members of this family are encoded within bacterial type III secretion gene clusters. Among all species with type III secretion, those with this protein are found among those that target animal rather than plant cells. The member of this family in Yersinia was shown by mutation to be required for type III secretion of Yops effector proteins and therefore is believed to be part of the secretion machinery.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene24167",433,110,83,174.389901852277,12,17,9,13.9727617511183,12.4807038836341,3.64162739613817,{"v":1.67052602501869e-16,"d":"1.67E-16"},{"v":7.22148151815277e-14,"d":"7.22E-14"},"up","yes","DNAH2","protein_coding","chrNC_037346.1:27414960-27523443:+","gi|741963098|ref|XP_010814356.1|",23709,0,"PREDICTED: dynein heavy chain 2, axonemal isoform X1 [Bos taurus]","gi|982957339|ref|XM_010816054.2|",13791,0,"PREDICTED: Bos taurus dynein, axonemal, heavy chain 2 (DNAH2), transcript variant X1, mRNA","P0C6F1",7796,0,"Dynein heavy chain 2, axonemal","YKR054c",826,0,"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.","GO:0007018|microtubule-based movement;","GO:0030286|dynein complex;GO:0036156|inner dynein arm;GO:0005874|microtubule;GO:0031514|motile cilium;","GO:0005524|ATP binding;GO:0008569|ATP-dependent microtubule motor activity, minus-end-directed;GO:0045505|dynein intermediate chain binding;GO:0045503|dynein light chain binding;GO:0051959|dynein light intermediate chain binding;",".","."]
["gene24169",134,76,82,85.0140313116176,23,26,37,31.4943397407478,2.69934318393172,1.43260840706853,0.00227648419650656,0.0337623647064661,"up","yes","TMEM88","protein_coding","chrNC_037346.1:27545968-27546947:+","gi|803235635|ref|XP_011977944.1|",328,{"v":5e-34,"d":"5.00E-34"},"PREDICTED: transmembrane protein 88 [Ovis aries musimon]","gi|402743705|ref|NM_001098378.2|",872,0,"Bos taurus transmembrane protein 88 (TMEM88), mRNA","A5D7M7",130,{"v":2e-35,"d":"2.00E-35"},"Transmembrane protein 88",".",".",".",".","pfam15279","SOBP","Sine oculis-binding protein. SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteristic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localisation signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.","GO:0007275|multicellular organismal development;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0072659|protein localization to plasma membrane;GO:0050821|protein stabilization;GO:0016055|Wnt signaling pathway;","GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0030165|PDZ domain binding;",".","."]
["gene24171",385,177,187,215.777720886223,49,74,68,70.0178729390986,3.08175201314535,1.62375077366328,{"v":4.4037004273274e-06,"d":"4.40E-06"},0.000211518479616293,"up","yes","CYB5D1","protein_coding","chrNC_037346.1:27548824-27553003:+","gi|528995137|ref|XP_005220389.1|",1218,{"v":1e-155,"d":"1.00E-155"},"PREDICTED: cytochrome b5 domain-containing protein 1 isoform X1 [Bos taurus]","gi|982957142|ref|XM_005220332.3|",3310,0,"PREDICTED: Bos taurus cytochrome b5 domain containing 1 (CYB5D1), transcript variant X1, mRNA","Q6P9G0",426,{"v":6e-139,"d":"6.00E-139"},"Cytochrome b5 domain-containing protein 1",".",".",".",".","pfam00173","Cyt-b5","Cytochrome b5-like Heme/Steroid binding domain. This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.",".",".","GO:0046872|metal ion binding;",".","."]
["gene2418",780,1458,2263,1376.11475787059,210,360,234,295.074479673084,4.66361834949332,2.22144972939983,{"v":5.36877365008564e-08,"d":"5.37E-08"},{"v":4.83206564702187e-06,"d":"4.83E-06"},"up","yes","CHRND","protein_coding","chrNC_037329.1:120166846-120174105:+","gi|56687505|ref|NP_776696.1|",2411,0,"acetylcholine receptor subunit delta precursor [Bos taurus]","gi|56687504|ref|NM_174271.1|",1832,0,"Bos taurus cholinergic receptor, nicotinic delta (CHRND), mRNA","P04759",933,0,"Acetylcholine receptor subunit delta",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0098655|cation transmembrane transport;GO:0050881|musculoskeletal movement;GO:0007274|neuromuscular synaptic transmission;GO:0035094|response to nicotine;GO:0048630|skeletal muscle tissue growth;GO:0007271|synaptic transmission, cholinergic;","GO:0005892|acetylcholine-gated channel complex;GO:0030054|cell junction;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0045211|postsynaptic membrane;","GO:0042166|acetylcholine binding;GO:0022848|acetylcholine-gated cation channel activity;GO:0004888|transmembrane signaling receptor activity;","K04816","CHRND; nicotinic acetylcholine receptor delta"]
["gene24193",7617,13378,6921,8494.96313360888,1519,1981,2077,2044.49679247631,4.15503862117568,2.05486188694018,{"v":6.57264854192875e-15,"d":"6.57E-15"},{"v":2.25932813915385e-12,"d":"2.26E-12"},"up","yes","PER1","protein_coding","chrNC_037346.1:27778457-27793756:-","gi|576795884|ref|NP_001276701.1|",4216,0,"period circadian protein homolog 1 [Bos taurus]","gi|982957218|ref|XM_010816024.2|",8300,0,"PREDICTED: Bos taurus period circadian clock 1 (PER1), transcript variant X1, mRNA","O15534",1198,0,"Period circadian protein homolog 1",".",".",".",".","pfam12114","Period_C","Period protein 2/3C-terminal region. This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.","GO:0032922|circadian regulation of gene expression;GO:0097167|circadian regulation of translation;GO:0007623|circadian rhythm;GO:0009649|entrainment of circadian clock;GO:0043153|entrainment of circadian clock by photoperiod;GO:0043966|histone H3 acetylation;GO:0070932|histone H3 deacetylation;GO:0043967|histone H4 acetylation;GO:2000323|negative regulation of glucocorticoid receptor signaling pathway;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046329|negative regulation of JNK cascade;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0010608|posttranscriptional regulation of gene expression;GO:0042752|regulation of circadian rhythm;GO:1900015|regulation of cytokine production involved in inflammatory response;GO:0042634|regulation of hair cycle;GO:1900744|regulation of p38MAPK cascade;GO:0002028|regulation of sodium ion transport;GO:0051591|response to cAMP;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0031490|chromatin DNA binding;GO:0070888|E-box binding;GO:0019900|kinase binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0031625|ubiquitin protein ligase binding;",".","."]
["gene24218",857,223,339,400.54939022485,158,153,166,175.125955787835,2.28720744690818,1.19358722235343,0.00011546287830061,0.00326165483247001,"up","yes","ARHGEF15","protein_coding","chrNC_037346.1:27923138-27936115:+","gi|329664382|ref|NP_001192641.1|",3151,0,"rho guanine nucleotide exchange factor 15 [Bos taurus]","gi|742136960|ref|XM_010843038.1|",4563,0,"PREDICTED: Bison bison bison Rho guanine nucleotide exchange factor (GEF) 15 (ARHGEF15), mRNA","O94989",1022,0,"Rho guanine nucleotide exchange factor 15","SPCC645.07",75.5,{"v":1e-12,"d":"1.00E-12"},"COG5422","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:2000297|negative regulation of synapse maturation;GO:0051496|positive regulation of stress fiber assembly;GO:0050790|regulation of catalytic activity;GO:0035023|regulation of Rho protein signal transduction;GO:0061299|retina vasculature morphogenesis in camera-type eye;","GO:0005737|cytoplasm;GO:0030425|dendrite;","GO:0005096|GTPase activator activity;GO:0005089|Rho guanyl-nucleotide exchange factor activity;",".","."]
["gene24243",6161,10501,13001,9039.95147003525,2091,4408,3261,3576.36286992808,2.52769414033678,1.33782190302633,0.00341212160861571,0.0453640454871458,"up","yes","DHRS7C","protein_coding","chrNC_037346.1:28955391-28968730:-","gi|528995159|ref|XP_005220400.1|",1568,0,"PREDICTED: dehydrogenase/reductase SDR family member 7C isoform X1 [Bos taurus]","gi|982957170|ref|XM_005220343.3|",1137,0,"PREDICTED: Bos taurus dehydrogenase/reductase (SDR family) member 7C (DHRS7C), transcript variant X1, mRNA","Q1RMJ5",601,0,"Dehydrogenase/reductase SDR family member 7C",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0010880|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum;","GO:0005576|extracellular region;GO:0014801|longitudinal sarcoplasmic reticulum;GO:0033017|sarcoplasmic reticulum membrane;","GO:0004745|retinol dehydrogenase activity;","K11167","DHRS7C; dehydrogenase/reductase SDR family member 7C [EC:1.1.-.-]"]
["gene24250",421,465,69,283.302496258069,119,100,143,132.796282679759,2.13336164643447,1.09312855137565,0.00126601343758439,0.0218229179828918,"up","yes","MYH8","protein_coding","chrNC_037346.1:29403330-29433354:-","gi|329663986|ref|NP_001193103.1|",9327,0,"myosin-8 [Bos taurus]","gi|329663985|ref|NM_001206174.1|",6020,0,"Bos taurus myosin, heavy chain 8, skeletal muscle, perinatal (MYH8), mRNA","Q076A4",3518,0,"Myosin-8","SPCC645.05c",751,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0046034|ATP metabolic process;GO:0007018|microtubule-based movement;GO:0030049|muscle filament sliding;GO:0003009|skeletal muscle contraction;","GO:0030016|myofibril;GO:0032982|myosin filament;","GO:0051015|actin filament binding;GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0005516|calmodulin binding;GO:0000146|microfilament motor activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10352","MYH; myosin heavy chain"]
["gene24251",5,191,85,90.0025317693287,6,7,5,6.61638596630162,13.6029748306291,3.76585028342757,{"v":3.79091481830679e-11,"d":"3.79E-11"},{"v":6.84548042285512e-09,"d":"6.85E-09"},"up","yes","MYH4","protein_coding","chrNC_037346.1:29452897-29475756:-","gi|297486816|ref|XP_002695852.1|",9234,0,"PREDICTED: myosin-4 [Bos taurus]","gi|983001787|ref|XM_015468059.1|",5795,0,"PREDICTED: Bos taurus myosin, heavy chain 4, skeletal muscle (MYH4), mRNA","Q9TV62",3485,0,"Myosin-4","SPCC645.05c",754,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0007018|microtubule-based movement;GO:0006936|muscle contraction;GO:0014823|response to activity;","GO:0030016|myofibril;GO:0032982|myosin filament;","GO:0051015|actin filament binding;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0003725|double-stranded RNA binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10352","MYH; myosin heavy chain"]
["gene24252",77343,252294,139656,145729.966027544,1236,3128,1896,2294.31907177484,63.5177416342576,5.98908771342966,{"v":6.32556672669912e-18,"d":"6.33E-18"},{"v":3.40518385432929e-15,"d":"3.41E-15"},"up","yes","MYH1","protein_coding","chrNC_037346.1:29483025-29507379:-","gi|41386691|ref|NP_776542.1|",9309,0,"myosin-1 [Bos taurus]","gi|41386690|ref|NM_174117.1|",5987,0,"Bos taurus myosin, heavy chain 1, skeletal muscle, adult (MYH1), mRNA","Q9BE40",3568,0,"Myosin-1","SPCC645.05c",769,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0007018|microtubule-based movement;","GO:0031672|A band;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0014704|intercalated disc;GO:0005859|muscle myosin complex;GO:0032982|myosin filament;","GO:0051015|actin filament binding;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10352","MYH; myosin heavy chain"]
["gene24254",421,194,45,187.120085986488,62,25,43,47.8701450196883,3.9089099460536,1.96676634802489,0.000714545165947463,0.0140114695049121,"up","yes","MYH3","protein_coding","chrNC_037346.1:29601526-29622481:-","gi|156120319|ref|NP_001095305.1|",9399,0,"myosin-3 [Bos taurus]","gi|156120318|ref|NM_001101835.1|",6103,0,"Bos taurus myosin, heavy chain 3, skeletal muscle, embryonic (MYH3), mRNA","P11055",3541,0,"Myosin-3","SPCC645.05c",757,0,"COG5022","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0030048|actin filament-based movement;GO:0046034|ATP metabolic process;GO:0030326|embryonic limb morphogenesis;GO:0060325|face morphogenesis;GO:0007018|microtubule-based movement;GO:0030049|muscle filament sliding;GO:0007517|muscle organ development;GO:0045214|sarcomere organization;GO:0003009|skeletal muscle contraction;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005859|muscle myosin complex;GO:0032982|myosin filament;GO:0030017|sarcomere;","GO:0051015|actin filament binding;GO:0005524|ATP binding;GO:0042623|ATPase activity, coupled;GO:0005516|calmodulin binding;GO:0000146|microfilament motor activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0017018|myosin phosphatase activity;","K10352","MYH; myosin heavy chain"]
["gene24265",380,67,157,169.212010981074,45,27,41,41.5281168476177,4.07463722956609,2.02667161998093,{"v":3.52447206831587e-07,"d":"3.52E-07"},{"v":2.47068089879902e-05,"d":"2.47E-05"},"up","yes","MYOCD","protein_coding","chrNC_037346.1:30952613-31188716:+","gi|528995396|ref|XP_002695856.3|",4223,0,"PREDICTED: myocardin isoform X1 [Bos taurus]","gi|983001796|ref|XM_015468063.1|",8391,0,"PREDICTED: Bos taurus myocardin (MYOCD), transcript variant X1, mRNA","Q7YR76",1300,0,"Myocardin",".",".",".",".","pfam02037","SAP","SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.","GO:0055007|cardiac muscle cell differentiation;GO:2000727|positive regulation of cardiac muscle cell differentiation;GO:0035065|regulation of histone acetylation;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0051145|smooth muscle cell differentiation;","GO:0005634|nucleus;","GO:0001105|RNA polymerase II transcription coactivator activity;",".","."]
["gene24276",1209,3283,3218,2379.30805112109,920,820,870,958.842862495758,2.48143689042855,1.3111757635113,{"v":3.4818504840978e-07,"d":"3.48E-07"},{"v":2.45285620152579e-05,"d":"2.45E-05"},"up","yes","PMP22","protein_coding","chrNC_037346.1:32755620-32784018:-","gi|155372037|ref|NP_001094626.1|",619,{"v":1e-73,"d":"1.00E-73"},"peripheral myelin protein 22 [Bos taurus]","gi|155372036|ref|NM_001101156.1|",1797,0,"Bos taurus peripheral myelin protein 22 (PMP22), mRNA","Q9TQZ3",243,{"v":5e-75,"d":"5.00E-75"},"Peripheral myelin protein 22",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0032060|bleb assembly;GO:0007050|cell cycle arrest;GO:0008219|cell death;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".","K19289","PMP22; peripheral myelin protein 22"]
["gene24328",869,1294,833,906.380590499546,307,335,336,358.974529818512,2.52491615758306,1.33623548249913,{"v":4.20034498947155e-07,"d":"4.20E-07"},{"v":2.88077026188973e-05,"d":"2.88E-05"},"up","yes","SMCR8","protein_coding","chrNC_037346.1:34349857-34358888:-","gi|555950285|ref|XP_005887346.1|",4501,0,"PREDICTED: Smith-Magenis syndrome chromosomal region candidate gene 8 protein [Bos mutus]","gi|965823774|ref|XM_012127416.2|",5516,0,"PREDICTED: Ovis aries musimon Smith-Magenis syndrome chromosome region, candidate 8 (SMCR8), mRNA","Q8TEV9",1517,0,"Guanine nucleotide exchange protein SMCR8",".",".",".",".","pfam04094","DUF390","Protein of unknown function (DUF390). This is a family of long proteins currently only found in the rice genome. They have no known function. However they may be some kind of transposable element.","GO:0006914|autophagy;GO:1902902|negative regulation of autophagosome assembly;GO:0010629|negative regulation of gene expression;GO:0016242|negative regulation of macroautophagy;GO:0006469|negative regulation of protein kinase activity;GO:1901098|positive regulation of autophagosome maturation;GO:0032008|positive regulation of TOR signaling;GO:0010506|regulation of autophagy;GO:1903432|regulation of TORC1 signaling;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:1990316|ATG1/UKL1 kinase complex;GO:0000785|chromatin;GO:0005737|cytoplasm;GO:0032045|guanyl-nucleotide exchange factor complex;GO:0005654|nucleoplasm;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0019901|protein kinase binding;GO:0004860|protein kinase inhibitor activity;",".","."]
["gene24368",1319,2598,2141,1852.71999752063,272,477,459,442.404546738291,4.18784122175088,2.06620674481528,{"v":1.61976804278219e-08,"d":"1.62E-08"},{"v":1.64146295665343e-06,"d":"1.64E-06"},"up","yes","KCNJ12","protein_coding","chrNC_037346.1:35328131-35365898:+","gi|742136356|ref|XP_010841159.1|",2327,0,"PREDICTED: ATP-sensitive inward rectifier potassium channel 12 isoform X1 [Bison bison bison]","gi|982957600|ref|XM_005220595.3|",5335,0,"PREDICTED: Bos taurus potassium channel, inwardly rectifying subfamily J, member 12 (KCNJ12), transcript variant X1, mRNA","Q4TZY1",855,0,"ATP-sensitive inward rectifier potassium channel 12",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.","GO:0010107|potassium ion import;GO:0006813|potassium ion transport;GO:0051289|protein homotetramerization;GO:0034765|regulation of ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0031224|intrinsic component of membrane;","GO:0005242|inward rectifier potassium channel activity;",".","."]
["gene24380",608,2099,2587,1640.86200279521,403,319,443,427.608564436927,3.83729920132888,1.94009125893196,{"v":6.55225309823325e-14,"d":"6.55E-14"},{"v":1.92724054789374e-11,"d":"1.93E-11"},"up","yes","WFIKKN2","protein_coding","chrNC_037346.1:35907559-35914501:-","gi|116003997|ref|NP_001070353.1|",2621,0,"WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 precursor [Bos taurus]","gi|742136282|ref|XM_010842839.1|",3267,0,"PREDICTED: Bison bison bison WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 (WFIKKN2), transcript variant X5, mRNA","Q08E66",1014,0,"WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2",".",".",".",".","pfam00014","Kunitz_BPTI","Kunitz/Bovine pancreatic trypsin inhibitor domain. Indicative of a protease inhibitor, usually a serine protease inhibitor. Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure. Certain family members are similar to the tick anticoagulant peptide (TAP). This is a highly selective inhibitor of factor Xa in the blood coagulation pathways. TAP molecules are highly dipolar, and are arranged to form a twisted two- stranded antiparallel beta-sheet followed by an alpha helix.",".","GO:0005576|extracellular region;","GO:0008191|metalloendopeptidase inhibitor activity;GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["gene24383",4756,788,933,1784.31012976417,621,967,724,848.331334457753,2.10331748609131,1.07266663468146,0.00125519218631154,0.0216778984671033,"up","yes","LUC7L3","protein_coding","chrNC_037346.1:35993170-36018077:-","gi|926717431|ref|XP_005693712.2|",1374,0,"PREDICTED: luc7-like protein 3 isoform X2 [Capra hircus]","gi|77736312|ref|NM_001034684.1|",1864,0,"Bos taurus LUC7-like 3 pre-mRNA splicing factor (LUC7L3), mRNA","Q5R8W6",478,{"v":6e-162,"d":"6.00E-162"},"Luc7-like protein 3","SPCC16A11.13",116,{"v":7e-28,"d":"7.00E-28"},"COG5200","pfam03194","LUC7","LUC7 N_terminus. This family contains the N terminal region of several LUC7 protein homologues and only contains eukaryotic proteins. LUC7 has been shown to be a U1 snRNA associated protein with a role in splice site recognition. The family also contains human and mouse LUC7 like (LUC7L) proteins and human cisplatin resistance-associated overexpressed protein (CROP).","GO:0006376|mRNA splice site selection;GO:0008380|RNA splicing;","GO:0016607|nuclear speck;GO:0005634|nucleus;GO:0005685|U1 snRNP;","GO:0003677|DNA binding;GO:0003729|mRNA binding;",".","."]
["gene24404",30009,22383,23625,22412.0961218904,10199,4549,8737,8635.30732954459,2.59540225571478,1.3759581560592,0.00322570983392721,0.0435406939705154,"up","yes","COL1A1","protein_coding","chrNC_037346.1:36457701-36475647:+","gi|77404252|ref|NP_001029211.1|",1702,0,"collagen alpha-1(I) chain precursor [Bos taurus]","gi|594032935|ref|XM_006041152.1|",4451,0,"PREDICTED: Bubalus bubalis collagen alpha-1(I) chain-like (LOC102391895), mRNA","P02453",660,0,"Collagen alpha-1(I) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001568|blood vessel development;GO:0060346|bone trabecula formation;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0071230|cellular response to amino acid stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0032964|collagen biosynthetic process;GO:0030199|collagen fibril organization;GO:0048706|embryonic skeletal system development;GO:0001958|endochondral ossification;GO:0060325|face morphogenesis;GO:0001957|intramembranous ossification;GO:0010812|negative regulation of cell-substrate adhesion;GO:0001649|osteoblast differentiation;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0030335|positive regulation of cell migration;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0045893|positive regulation of transcription, DNA-templated;GO:0070208|protein heterotrimerization;GO:0034504|protein localization to nucleus;GO:0015031|protein transport;GO:0007605|sensory perception of sound;GO:0043589|skin morphogenesis;GO:0034505|tooth mineralization;GO:0007601|visual perception;","GO:0005584|collagen type I trimer;GO:0005737|cytoplasm;GO:0005615|extracellular space;","GO:0005201|extracellular matrix structural constituent;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;GO:0002020|protease binding;","K06236","COL1AS; collagen, type I/II/III/V/XI/XXIV/XXVII, alpha"]
["gene24406",2581,9397,6101,5625.98069242163,2084,2286,2501,2520.65947667673,2.23194792651603,1.15830336810193,{"v":1.67519610855394e-05,"d":"1.68E-05"},0.000655774980821891,"up","yes","SGCA","protein_coding","chrNC_037346.1:36482941-36492533:-","gi|528995821|ref|XP_005220680.1|",1736,0,"PREDICTED: alpha-sarcoglycan isoform X1 [Bos taurus]","gi|982957629|ref|XM_005220623.3|",1476,0,"PREDICTED: Bos taurus sarcoglycan alpha (SGCA), transcript variant X1, mRNA","Q16586",598,0,"Alpha-sarcoglycan",".",".",".",".","pfam05510","Sarcoglycan_2","Sarcoglycan alpha/epsilon. Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localisation of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.","GO:0061024|membrane organization;GO:0006936|muscle contraction;GO:0007517|muscle organ development;GO:0014894|response to denervation involved in regulation of muscle adaptation;GO:0043403|skeletal muscle tissue regeneration;","GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0016010|dystrophin-associated glycoprotein complex;GO:0016021|integral component of membrane;GO:0045121|membrane raft;GO:0016012|sarcoglycan complex;GO:0042383|sarcolemma;","GO:0005509|calcium ion binding;","K12565","SGCA; alpha-sarcoglycan"]
["gene24407",0,40,0,13.1087071682637,0,0,1,0.360972888453242,36.3149355189363,5.18249111328783,0.000489285111314634,0.0104109159814854,"up","yes","HILS1","protein_coding","chrNC_037346.1:36486101-36487197:+","gi|744066803|ref|NP_001290338.1|",767,{"v":3e-98,"d":"3.00E-98"},"histone linker H1 domain, spermatid-specific 1 [Bos taurus]","gi|109658231|gb|BC118206.1|",1097,0,"Bos taurus cDNA clone IMAGE:8215890","D3ZZW6",140,{"v":2e-38,"d":"2.00E-38"},"Spermatid-specific linker histone H1-like protein",".",".",".",".","pfam00538","Linker_histone","linker histone H1 and H5 family. Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.","GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0006334|nucleosome assembly;GO:0006355|regulation of transcription, DNA-templated;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;","GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;",".","."]
["gene24460",66,22,168,76.0073570198961,14,24,33,25.952560237292,2.92870361632679,1.55026220042423,0.00305296216776037,0.0419172587143268,"up","yes","HOXB2","protein_coding","chrNC_037346.1:37946400-37948660:+","gi|803246206|ref|XP_011983099.1|",1231,{"v":9e-164,"d":"9.00E-164"},"PREDICTED: homeobox protein Hox-B2 isoform X2 [Ovis aries musimon]","gi|999809105|ref|NM_001191335.2|",1493,0,"Bos taurus homeobox B2 (HOXB2), mRNA","P14652",412,{"v":6e-139,"d":"6.00E-139"},"Homeobox protein Hox-B2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009952|anterior/posterior pattern specification;GO:0008015|blood circulation;GO:0009953|dorsal/ventral pattern formation;GO:0048704|embryonic skeletal system morphogenesis;GO:0021612|facial nerve structural organization;GO:0002011|morphogenesis of an epithelial sheet;GO:0007275|multicellular organismal development;GO:0048857|neural nucleus development;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0021569|rhombomere 3 development;GO:0021570|rhombomere 4 development;","GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09302","HOX_2; homeobox protein HoxA/B2"]
["gene24463",36,69,205,94.9548912810193,30,35,22,31.9990111661484,2.96743204932131,1.569214994238,0.000952620558110691,0.0173780160763786,"up","yes","SKAP1","protein_coding","chrNC_037346.1:38060681-38366730:+","gi|821418049|ref|XP_012393259.1|",1149,{"v":1e-174,"d":"1.00E-174"},"PREDICTED: src kinase-associated phosphoprotein 1 [Orcinus orca]","gi|983001959|ref|XM_003583599.4|",1176,0,"PREDICTED: Bos taurus src kinase associated phosphoprotein 1 (SKAP1), mRNA","Q86WV1",414,{"v":2e-156,"d":"2.00E-156"},"Src kinase-associated phosphoprotein 1",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.","GO:0002250|adaptive immune response;GO:0045785|positive regulation of cell adhesion;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0072659|protein localization to plasma membrane;GO:0050852|T cell receptor signaling pathway;","GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0042101|T cell receptor complex;","GO:0019901|protein kinase binding;GO:0019903|protein phosphatase binding;GO:0044877|macromolecular complex binding;GO:0042169|SH2 domain binding;GO:0017124|SH3 domain binding;GO:0005070|SH3/SH2 adaptor activity;","K17699","SKAP1, SKAP55; src kinase associated phosphoprotein 1"]
["gene24511",7402,7661,13957,8726.27497973161,3378,3418,3964,3947.84864927911,2.21038741728993,1.14429925469288,{"v":2.50320132107196e-05,"d":"2.50E-05"},0.000906323265262789,"up","yes","RPL23","protein_coding","chrNC_037346.1:39438651-39443013:-","gi|965930210|ref|XP_014950645.1|",731,{"v":3e-96,"d":"3.00E-96"},"PREDICTED: 60S ribosomal protein L23-like, partial [Ovis aries]","gi|742135726|ref|XM_010842689.1|",495,0,"PREDICTED: Bison bison bison ribosomal protein L23 (RPL23), mRNA","P62832",261,{"v":2e-88,"d":"2.00E-88"},"60S ribosomal protein L23","YER117w",219,{"v":2e-72,"d":"2.00E-72"},"COG0093","pfam00238","Ribosomal_L14","Ribosomal protein L14p/L23e.","GO:0072717|cellular response to actinomycin D;GO:0071157|negative regulation of cell cycle arrest;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:2000059|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;GO:0071158|positive regulation of cell cycle arrest;GO:0008284|positive regulation of cell proliferation;GO:1901798|positive regulation of signal transduction by p53 class mediator;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0050821|protein stabilization;GO:0032986|protein-DNA complex disassembly;GO:0006412|translation;","GO:0022625|cytosolic large ribosomal subunit;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005840|ribosome;","GO:0070180|large ribosomal subunit rRNA binding;GO:0003735|structural constituent of ribosome;GO:0001223|transcription coactivator binding;GO:0031625|ubiquitin protein ligase binding;","K02894","RP-L23e, RPL23; large subunit ribosomal protein L23e"]
["gene24520",1749,1520,1882,1531.963828071,450,231,415,402.773517727855,3.80353662950133,1.92734149881692,{"v":2.00953252294049e-06,"d":"2.01E-06"},0.000110654995024512,"up","yes","PLXDC1","protein_coding","chrNC_037346.1:39590715-39657241:-","gi|149642769|ref|NP_001092547.1|",2250,0,"plexin domain-containing protein 1 precursor [Bos taurus]","gi|149642768|ref|NM_001099077.1|",2717,0,"Bos taurus plexin domain containing 1 (PLXDC1), mRNA","Q8IUK5",794,0,"Plexin domain-containing protein 1",".",".",".",".","pfam01437","PSI","Plexin repeat. A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).","GO:0001525|angiogenesis;GO:0021510|spinal cord development;","GO:0005923|bicellular tight junction;GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0043025|neuronal cell body;GO:0005886|plasma membrane;GO:0043235|receptor complex;",".",".","."]
["gene24653",0,37,0,12.1255541306439,0,0,0,0,"Inf","Inf",0.000167413481177416,0.00443498053061546,"up","yes","KLHL10","protein_coding","chrNC_037346.1:42024147-42037172:+","gi|655871320|ref|XP_002719434.2|",3326,0,"PREDICTED: kelch-like protein 10 [Oryctolagus cuniculus]","gi|965960420|ref|XM_004012910.3|",2141,0,"PREDICTED: Ovis aries kelch like family member 10 (KLHL10), mRNA","Q6JEL3",1247,0,"Kelch-like protein 10",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0000902|cell morphogenesis;GO:0009566|fertilization;GO:0048873|homeostasis of number of cells within a tissue;GO:0048808|male genitalia morphogenesis;GO:0008584|male gonad development;GO:0016567|protein ubiquitination;GO:0007286|spermatid development;","GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0005737|cytoplasm;",".","K10448","KLHL10; kelch-like protein 10"]
["gene24657",446,840,1054,715.227015985427,151,287,162,220.242021847313,3.24745936305139,1.6993114726813,0.000528552770099797,0.0109833496603913,"up","yes","CNP","protein_coding","chrNC_037346.1:42130845-42138137:+","gi|528995958|ref|XP_005220718.1|",2227,0,"PREDICTED: 2',3'-cyclic-nucleotide 3'-phosphodiesterase isoform X1 [Bos taurus]","gi|528995957|ref|XM_005220661.1|",2505,0,"PREDICTED: Bos taurus 2',3'-cyclic nucleotide 3' phosphodiesterase (CNP), transcript variant X1, mRNA","P06623",821,0,"2',3'-cyclic-nucleotide 3'-phosphodiesterase",".",".",".",".","pfam05881","CNPase","2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase). This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterized by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.","GO:0008344|adult locomotory behavior;GO:0007409|axonogenesis;GO:0009214|cyclic nucleotide catabolic process;GO:0048709|oligodendrocyte differentiation;GO:0009636|response to toxic substance;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005615|extracellular space;GO:0042470|melanosome;GO:0016020|membrane;GO:0043209|myelin sheath;GO:0005654|nucleoplasm;","GO:0004113|2',3'-cyclic-nucleotide 3'-phosphodiesterase activity;GO:0003723|RNA binding;","K01121","CNP; 2',3'-cyclic-nucleotide 3'-phosphodiesterase [EC:3.1.4.37]"]
["gene24664",0,61,5,21.5263865996426,0,0,0,0,"Inf","Inf",{"v":6.215209770713e-07,"d":"6.22E-07"},{"v":4.05780663542821e-05,"d":"4.06E-05"},"up","yes","HSPB9","protein_coding","chrNC_037346.1:42257571-42258088:+","gi|94966950|ref|NP_001035667.1|",752,{"v":3e-99,"d":"3.00E-99"},"heat shock protein beta-9 [Bos taurus]","gi|402747143|ref|NM_001040577.2|",518,0,"Bos taurus heat shock protein family B (small) member 9 (HSPB9), mRNA","Q2TBQ6",294,{"v":9e-101,"d":"9.00E-101"},"Heat shock protein beta-9",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.",".","GO:0005737|cytoplasm;GO:0005634|nucleus;",".","K09547","HSPB9; heat shock protein beta-9"]
["gene24668",519,974,849,715.206746398492,241,227,278,273.734750885162,2.61277292738961,1.3855817474042,{"v":5.2468883937261e-07,"d":"5.25E-07"},{"v":3.50583074382668e-05,"d":"3.51E-05"},"up","yes","GHDC","protein_coding","chrNC_037346.1:42307202-42311698:-","gi|741963745|ref|XP_010814550.1|",2585,0,"PREDICTED: GH3 domain-containing protein isoform X3 [Bos taurus]","gi|982957835|ref|XM_010816248.2|",2394,0,"PREDICTED: Bos taurus GH3 domain containing (GHDC), transcript variant X3, mRNA","Q8N2G8",773,0,"GH3 domain-containing protein",".",".",".",".","pfam03321","GH3","GH3 auxin-responsive promoter.","GO:0043312|neutrophil degranulation;","GO:0005783|endoplasmic reticulum;GO:0005576|extracellular region;GO:0016020|membrane;GO:0005635|nuclear envelope;GO:0034774|secretory granule lumen;GO:0035580|specific granule lumen;",".",".","."]
["gene24677",278,367,348,299.603976604905,125,83,140,127.717183882688,2.34583920109059,1.23010412515677,0.00031120477189509,0.00722455927334322,"up","yes","NAGLU","protein_coding","chrNC_037346.1:42618464-42625472:+","gi|528996185|ref|XP_005220827.1|",3591,0,"PREDICTED: alpha-N-acetylglucosaminidase isoform X1 [Bos taurus]","gi|982957885|ref|XM_005220770.3|",2506,0,"PREDICTED: Bos taurus N-acetylglucosaminidase, alpha (NAGLU), transcript variant X1, mRNA","P54802",1220,0,"Alpha-N-acetylglucosaminidase",".",".",".",".","pfam05089","NAGLU","Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold.","GO:0021680|cerebellar Purkinje cell layer development;GO:0006027|glycosaminoglycan catabolic process;GO:0060119|inner ear receptor cell development;GO:0045475|locomotor rhythm;GO:0007040|lysosome organization;GO:0042474|middle ear morphogenesis;GO:0007399|nervous system development;GO:0046548|retinal rod cell development;","GO:0070062|extracellular exosome;GO:0043202|lysosomal lumen;GO:0005764|lysosome;","GO:0004561|alpha-N-acetylglucosaminidase activity;","K01205","NAGLU; alpha-N-acetylglucosaminidase [EC:3.2.1.50]"]
["gene24714",79,615,832,477.660807584055,91,66,92,91.443581497826,5.22355751776204,2.3850326928324,{"v":2.56419451171286e-14,"d":"2.56E-14"},{"v":7.95206887105215e-12,"d":"7.95E-12"},"up","yes","RND2","protein_coding","chrNC_037346.1:43052388-43058498:+","gi|528996062|ref|XP_005220769.1|",831,{"v":7e-100,"d":"7.00E-100"},"PREDICTED: rho-related GTP-binding protein RhoN isoform X1 [Bos taurus]","gi|982957814|ref|XM_005220712.3|",3513,0,"PREDICTED: Bos taurus Rho family GTPase 2 (RND2), transcript variant X1, mRNA","P52198",295,{"v":5e-90,"d":"5.00E-90"},"Rho-related GTP-binding protein RhoN",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0048672|positive regulation of collateral sprouting;GO:0007165|signal transduction;GO:0007264|small GTPase mediated signal transduction;","GO:0002080|acrosomal membrane;GO:0005769|early endosome;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0047485|protein N-terminus binding;","K07858","RND2; Rho family GTPase 2"]
["gene24746",44,118,113,84.8428531648866,10,23,22,20.1197985345774,4.21688383306014,2.07617727872483,{"v":3.14204642212146e-05,"d":"3.14E-05"},0.00110186412031176,"up","yes","ARL4D","protein_coding","chrNC_037346.1:43334271-43344320:+","gi|115497610|ref|NP_001069603.1|",985,{"v":6e-125,"d":"6.00E-125"},"ADP-ribosylation factor-like protein 4D [Bos taurus]","gi|115497609|ref|NM_001076135.1|",1285,0,"Bos taurus ADP ribosylation factor like GTPase 4D (ARL4D), mRNA","Q0VC18",384,{"v":2e-126,"d":"2.00E-126"},"ADP-ribosylation factor-like protein 4D",".",".",".",".","pfam00025","Arf","ADP-ribosylation factor family. Pfam combines a number of different Prosite families together",".","GO:0005737|cytoplasm;GO:0005730|nucleolus;GO:0005886|plasma membrane;","GO:0005525|GTP binding;","K07945","ARL4; ADP-ribosylation factor-like protein 4"]
["gene24767",1404,5981,4076,3577.82224243929,501,1193,861,935.871639945275,3.82298393254923,1.93469913674586,0.000463114002211569,0.00994962770865833,"up","yes","ASB16","protein_coding","chrNC_037346.1:43989607-43997145:+","gi|155372099|ref|NP_001094658.1|",2036,0,"ankyrin repeat and SOCS box protein 16 [Bos taurus]","gi|155372098|ref|NM_001101188.1|",2611,0,"Bos taurus ankyrin repeat and SOCS box containing 16 (ASB16), mRNA","Q96NS5",691,0,"Ankyrin repeat and SOCS box protein 16","all2748",80.1,{"v":7e-15,"d":"7.00E-15"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0035556|intracellular signal transduction;GO:0043687|post-translational protein modification;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;GO:0000151|ubiquitin ligase complex;","GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;","K10338","ASB16; ankyrin repeat and SOCS box protein 16"]
["gene24783",2,24,0,8.38647077463062,0,0,0,0,"Inf","Inf",0.00169675538528435,0.0273384522954315,"up","yes","MEIOC","protein_coding","chrNC_037346.1:44410581-44425749:+","gi|528921478|ref|XP_005195826.1|",4992,0,"PREDICTED: uncharacterized protein C17orf104 homolog isoform X1 [Bos taurus]","gi|983002277|ref|XM_005195769.3|",4561,0,"PREDICTED: Bos taurus meiosis specific with coiled-coil domain (MEIOC), transcript variant X1, mRNA","A2AG06",1767,0,"Meiosis-specific coiled-coil domain-containing protein MEIOC",".",".",".",".","pfam15189","DUF4582","Domain of unknown function (DUF4582). This family of proteins is found in eukaryotes. Proteins in this family are typically between 126 and 788 amino acids in length. In humans, it is encoded for on the chromosomal position, C17orf104.","GO:0070192|chromosome organization involved in meiosis;GO:0006302|double-strand break repair;GO:0007144|female meiosis I;GO:0051729|germline cell cycle switching, mitotic to meiotic cell cycle;GO:0007141|male meiosis I;GO:0051310|metaphase plate congression;GO:0048255|mRNA stabilization;GO:0048599|oocyte development;GO:0007286|spermatid development;GO:0007283|spermatogenesis;GO:0007130|synaptonemal complex assembly;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".",".","."]
["gene24800",499,1095,570,663.961185069105,181,329,243,276.107346415129,2.40472118431371,1.26586963024219,0.0018720825529469,0.0292991702238771,"up","yes","PLCD3","protein_coding","chrNC_037346.1:44781286-44802191:-","gi|300795645|ref|NP_001179957.1|",3983,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [Bos taurus]","gi|300795644|ref|NM_001193028.1|",2980,0,"Bos taurus phospholipase C delta 3 (PLCD3), mRNA","Q8N3E9",1266,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0001525|angiogenesis;GO:0043647|inositol phosphate metabolic process;GO:0035556|intracellular signal transduction;GO:0060716|labyrinthine layer blood vessel development;GO:0016042|lipid catabolic process;GO:0042127|regulation of cell proliferation;","GO:0032154|cleavage furrow;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0046872|metal ion binding;GO:0004435|phosphatidylinositol phospholipase C activity;","K05857","PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]"]
["gene24814",0,265,4,88.0736715241792,5,0,2,2.5907862278309,33.9949589734841,5.08724892351059,0.000280420740819125,0.00663957191395058,"up","yes","LOC614269","protein_coding","chrNC_037346.1:45159805-45209823:-","gi|296476205|tpg|DAA18320.1|",11898,0,"TPA: leucine rich repeat containing 37A-like protein [Bos taurus]","gi|983002312|ref|XM_015468192.1|",7308,0,"PREDICTED: Bos taurus leucine-rich repeat-containing protein 37A3 (LOC614269), mRNA","O60309",601,{"v":2e-178,"d":"2.00E-178"},"Leucine-rich repeat-containing protein 37A3","SPy1798",57.8,{"v":5e-07,"d":"5.00E-07"},"COG4886","pfam14914","LRRC37AB_C","LRRC37A/B like protein 1 C-terminal domain. This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene24826",0,31,0,10.1592480554043,0,1,0,0.366987568989444,27.6828124815762,4.79091861832076,0.0025858054951896,0.0370173690834192,"up","yes","SPPL2C","protein_coding","chrNC_037346.1:45852639-45854892:+","gi|76645330|ref|XP_591677.2|",2992,0,"PREDICTED: signal peptide peptidase-like 2C [Bos taurus]","gi|983002186|ref|XM_591677.5|",2156,0,"PREDICTED: Bos taurus signal peptide peptidase like 2C (SPPL2C), mRNA","A2A6C4",792,0,"Signal peptide peptidase-like 2C",".",".",".",".","pfam04258","Peptidase_A22B","Signal peptide peptidase. The members of this family are membrane proteins. In some proteins this region is found associated with pfam02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with pfam01080.",".","GO:0005789|endoplasmic reticulum membrane;GO:0030660|Golgi-associated vesicle membrane;GO:0071458|integral component of cytoplasmic side of endoplasmic reticulum membrane;GO:0071556|integral component of lumenal side of endoplasmic reticulum membrane;GO:0005765|lysosomal membrane;","GO:0004190|aspartic-type endopeptidase activity;GO:0042803|protein homodimerization activity;","K14212","SPPL2C, IMP5; signal peptide peptidase-like 2C [EC:3.4.23.-]"]
["gene24846",1866,2571,3480,2397.66839813271,946,587,1080,958.857035841205,2.50054837010111,1.32224451251601,0.000476941825499663,0.0102082724856196,"up","yes","MRC2","protein_coding","chrNC_037346.1:47043142-47103169:+","gi|330688482|ref|NP_001179599.1|",7488,0,"C-type mannose receptor 2 precursor [Bos taurus]","gi|330688481|ref|NM_001192670.1|",5565,0,"Bos taurus mannose receptor, C type 2 (MRC2), mRNA","Q9UBG0",2711,0,"C-type mannose receptor 2",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0030574|collagen catabolic process;GO:0006897|endocytosis;GO:0001649|osteoblast differentiation;","GO:0005925|focal adhesion;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0030246|carbohydrate binding;GO:0005518|collagen binding;GO:0004888|transmembrane signaling receptor activity;","K06560","MRC; mannose receptor, C type"]
["gene24848",1,34,2,12.0172675970765,0,0,0,0,"Inf","Inf",0.000174841457043217,0.00457651523935783,"up","yes","2020-03-10","protein_coding","chrNC_037346.1:47110510-47211485:-","gi|982958143|ref|XP_015314371.1|",3615,0,"PREDICTED: probable E3 ubiquitin-protein ligase MARCH10 isoform X4 [Bos taurus]","gi|965904691|ref|XR_001433211.1|",4297,0,"PREDICTED: Ovis aries musimon membrane associated ring-CH-type finger 10 (MARCH10), transcript variant X6, misc_RNA","Q8NA82",864,0,"Probable E3 ubiquitin-protein ligase MARCH10","SPBC14F5.07",56.2,{"v":1e-06,"d":"1.00E-06"},"COG5183","pfam12906","RINGv","RING-variant domain.","GO:0016567|protein ubiquitination;",".","GO:0016740|transferase activity;GO:0008270|zinc ion binding;","K10665","MARCH10; E3 ubiquitin-protein ligase MARCH10 [EC:2.3.2.27]"]
["gene24852",2374,1834,1821,1779.02228271441,575,781,643,733.639510512499,2.4249270346299,1.27794133766624,{"v":2.48141008879088e-07,"d":"2.48E-07"},{"v":1.81997715278387e-05,"d":"1.82E-05"},"up","yes","TANC2","protein_coding","chrNC_037346.1:47400816-47764657:+","gi|741964111|ref|XP_010814669.1|",9782,0,"PREDICTED: protein TANC2 isoform X1 [Bos taurus]","gi|982958125|ref|XM_015458881.1|",12275,0,"PREDICTED: Bos taurus tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 (TANC2), transcript variant X5, mRNA","Q9HCD6",3484,0,"Protein TANC2","all2748",154,{"v":4e-38,"d":"4.00E-38"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0001701|in utero embryonic development;",".",".",".","."]
["gene24858",0,24,4,9.09371083539061,0,0,0,0,"Inf","Inf",0.00106022402226364,0.0188939735035627,"up","yes","ACE3","protein_coding","chrNC_037346.1:47827666-47840921:+","gi|594039216|ref|XP_006044202.1|",3576,0,"PREDICTED: angiotensin-converting enzyme-like [Bubalus bubalis]","gi|965911236|ref|XM_012171405.2|",2245,0,"PREDICTED: Ovis aries musimon angiotensin-converting enzyme-like (LOC105613829), transcript variant X3, mRNA","D0G895",977,0,"Angiotensin-converting enzyme-like protein Ace3",".",".",".",".","pfam01401","Peptidase_M2","Angiotensin-converting enzyme. Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.",".","GO:0002080|acrosomal membrane;GO:0001669|acrosomal vesicle;GO:0016021|integral component of membrane;","GO:0008237|metallopeptidase activity;GO:0008241|peptidyl-dipeptidase activity;","K01283","ACE; peptidyl-dipeptidase A [EC:3.4.15.1]"]
["gene24873",6622,16050,11034,10374.495930827,2531,4279,3395,3741.84980026253,2.7725580888092,1.471217687099,{"v":3.14752114561034e-05,"d":"3.15E-05"},0.00110186412031176,"up","yes","SCN4A","protein_coding","chrNC_037346.1:48140013-48192955:-","gi|358417501|ref|XP_003583660.1|",8723,0,"PREDICTED: sodium channel protein type 4 subunit alpha isoform X1 [Bos taurus]","gi|983002360|ref|XM_015468204.1|",8033,0,"PREDICTED: Bos taurus sodium channel, voltage gated, type IV alpha subunit (SCN4A), transcript variant X3, mRNA","P35499",3099,0,"Sodium channel protein type 4 subunit alpha",".",".",".",".","pfam06512","Na_trans_assoc","Sodium ion transport-associated. Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.","GO:0086010|membrane depolarization during action potential;GO:0006936|muscle contraction;GO:0019228|neuronal action potential;GO:0034765|regulation of ion transmembrane transport;GO:0006814|sodium ion transport;","GO:0005887|integral component of plasma membrane;GO:0001518|voltage-gated sodium channel complex;","GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;","K04837","SCN4A; voltage-gated sodium channel type IV alpha"]
["gene24911",1024,962,641,779.007569059815,44,199,113,130.266258592251,5.98011777937218,2.58017389881181,0.000182566401663922,0.00469930391962991,"up","yes","ZNF750","protein_coding","chrNC_037346.1:49854993-49863770:+","gi|125630703|ref|NP_001075002.1|",3255,0,"zinc finger protein 750 [Bos taurus]","gi|125630702|ref|NM_001081533.1|",3097,0,"Bos taurus zinc finger protein 750 (ZNF750), mRNA","A2VDR9",1258,0,"Zinc finger protein 750",".",".",".",".","pfam15269","zf-C2H2_7","Zinc-finger. this is a family of eukaryotic zinc-fingers.","GO:0030154|cell differentiation;GO:0008544|epidermis development;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0001046|core promoter sequence-specific DNA binding;GO:0046872|metal ion binding;GO:1990841|promoter-specific chromatin binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;",".","."]
["gene24944",167,233,342,224.917898500754,106,57,87,91.9423502874281,2.44629268011553,1.29059702156393,0.00155194661413687,0.0255945600277104,"up","yes","LOC781977","protein_coding","chrNC_037346.1:50528364-50540214:+","gi|555951231|ref|XP_005887814.1|",1025,{"v":9e-131,"d":"9.00E-131"},"PREDICTED: secreted and transmembrane protein 1A-like, partial [Bos mutus]","gi|983002394|ref|XM_015468216.1|",922,0,"PREDICTED: Bos taurus uncharacterized LOC101903434 (LOC101903434), mRNA","Q8WVN6",119,{"v":3e-28,"d":"3.00E-28"},"Secreted and transmembrane protein 1",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.","GO:0006955|immune response;GO:0007498|mesoderm development;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;","GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005125|cytokine activity;",".","."]
["gene24948",1804,1809,1466,1513.24591580673,75,94,83,92.4901879904931,16.3611508278291,4.03220232453676,{"v":4.28474530231626e-51,"d":"4.28E-51"},{"v":2.4449613644077e-47,"d":"2.44E-47"},"up","yes","SLC16A3","protein_coding","chrNC_037346.1:50634317-50646382:-","gi|741964415|ref|XP_010814762.1|",1931,0,"PREDICTED: monocarboxylate transporter 4 isoform X1 [Bos taurus]","gi|982958339|ref|XM_010816461.2|",2322,0,"PREDICTED: Bos taurus solute carrier family 16 (monocarboxylate transporter), member 3 (SLC16A3), transcript variant X3, mRNA","O35910",654,0,"Monocarboxylate transporter 4",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0035879|plasma membrane lactate transport;","GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0031965|nuclear membrane;GO:0005886|plasma membrane;","GO:0015129|lactate transmembrane transporter activity;GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0015293|symporter activity;","K08180","SLC16A3; MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 3"]
["gene24982",889,818,942,789.075697997216,297,370,339,369.164332496654,2.13746461544837,1.09590053717294,{"v":4.16387951581264e-05,"d":"4.16E-05"},0.00138139123797268,"up","yes","MRPL12","protein_coding","chrNC_037346.1:51118070-51122424:-","gi|548509870|ref|XP_005694120.1|",617,{"v":2e-75,"d":"2.00E-75"},"PREDICTED: 39S ribosomal protein L12, mitochondrial [Capra hircus]","gi|146231923|gb|BT030597.1|",1117,0,"Bos taurus mitochondrial ribosomal protein L12 (MRPL12), nuclear gene encoding mitochondrial protein, mRNA, complete cds","Q7YR75",241,{"v":1e-76,"d":"1.00E-76"},"39S ribosomal protein L12, mitochondrial","YGL068w",48.9,{"v":5e-06,"d":"5.00E-06"},"COG0222","pfam00542","Ribosomal_L12","Ribosomal protein L7/L12 C-terminal domain.","GO:0006412|translation;","GO:0005743|mitochondrial inner membrane;GO:0005762|mitochondrial large ribosomal subunit;","GO:0003735|structural constituent of ribosome;","K02935","RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12"]
["gene25008",107,228,647,301.314014145019,110,56,87,93.0704350791782,3.23748367447386,1.69487291779842,0.000238088469851928,0.00578025066589453,"up","yes","NPTX1","protein_coding","chrNC_037346.1:52059956-52066350:+","gi|300797568|ref|NP_001179283.1|",2154,0,"neuronal pentraxin-1 precursor [Bos taurus]","gi|300797567|ref|NM_001192354.1|",2029,0,"Bos taurus neuronal pentraxin I (NPTX1), mRNA","Q62443",820,0,"Neuronal pentraxin-1",".",".",".",".","pfam00354","Pentaxin","Pentaxin family. Pentaxins are also known as pentraxins.","GO:0060385|axonogenesis involved in innervation;GO:0035865|cellular response to potassium ion;GO:0043653|mitochondrial fragmentation involved in apoptotic process;GO:0006839|mitochondrial transport;","GO:0005737|cytoplasm;GO:0005739|mitochondrion;GO:0043005|neuron projection;GO:0005886|plasma membrane;GO:0030133|transport vesicle;","GO:0046872|metal ion binding;",".","."]
["gene25010",3062,620,524,1162.14504831121,451,435,428,482.705397441778,2.40756588691632,1.2675752802813,{"v":2.52324897454163e-06,"d":"2.52E-06"},0.000131851312257596,"up","yes","LOC512869","protein_coding","chrNC_037346.1:52261217-52389779:-","gi|983002403|ref|XP_015323705.1|",26362,0,"PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF213 isoform X2 [Bos taurus]","gi|983002402|ref|XM_015468219.1|",13342,0,"PREDICTED: Bos taurus ring finger protein 213-like (LOC512869), transcript variant X2, mRNA","Q63HN8",6868,0,"E3 ubiquitin-protein ligase RNF213",".",".",".",".","pfam13923","zf-C3HC4_2","Zinc finger, C3HC4 type (RING finger).","GO:0001525|angiogenesis;GO:2000051|negative regulation of non-canonical Wnt signaling pathway;GO:0051865|protein autoubiquitination;GO:0051260|protein homooligomerization;GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0002040|sprouting angiogenesis;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0005730|nucleolus;","GO:0016887|ATPase activity;GO:0046872|metal ion binding;GO:0004842|ubiquitin-protein transferase activity;",".","."]
["gene25032",960,530,891,697.534052887075,141,177,146,170.360142141374,4.09446742717685,2.03367581080689,{"v":1.82540254714113e-13,"d":"1.83E-13"},{"v":5.00774616081573e-11,"d":"5.01E-11"},"up","yes","C1QTNF1","protein_coding","chrNC_037346.1:53359819-53384263:-","gi|440892468|gb|ELR45647.1|",1345,{"v":1e-172,"d":"1.00E-172"},"Complement C1q tumor necrosis factor-related protein 1, partial [Bos mutus]","gi|594081119|ref|XM_006064123.1|",2934,0,"PREDICTED: Bubalus bubalis C1q and tumor necrosis factor related protein 1 (C1QTNF1), transcript variant X2, mRNA","Q9BXJ1",445,{"v":1e-144,"d":"1.00E-144"},"Complement C1q tumor necrosis factor-related protein 1",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0010544|negative regulation of platelet activation;GO:0090331|negative regulation of platelet aggregation;GO:2000860|positive regulation of aldosterone secretion;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0010628|positive regulation of gene expression;GO:0043410|positive regulation of MAPK cascade;GO:0051897|positive regulation of protein kinase B signaling;GO:0070208|protein heterotrimerization;GO:0051260|protein homooligomerization;GO:0010906|regulation of glucose metabolic process;","GO:0005581|collagen trimer;GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0005518|collagen binding;",".","."]
["gene25046",93,596,1117,562.612562573146,185,124,213,191.540780479435,2.93729910238906,1.55449018141433,{"v":1.99917692723398e-05,"d":"2.00E-05"},0.000762547017525571,"up","yes","SOCS3","protein_coding","chrNC_037346.1:53839314-53842544:+","gi|27806151|ref|NP_776891.1|",1044,{"v":2e-132,"d":"2.00E-132"},"suppressor of cytokine signaling 3 [Bos taurus]","gi|982958517|ref|XM_005221139.3|",2514,0,"PREDICTED: Bos taurus suppressor of cytokine signaling 3 (SOCS3), transcript variant X1, mRNA","Q9BEG9",406,{"v":5e-134,"d":"5.00E-134"},"Suppressor of cytokine signaling 3",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0060670|branching involved in labyrinthine layer morphogenesis;GO:1990830|cellular response to leukemia inhibitory factor;GO:0019221|cytokine-mediated signaling pathway;GO:0007259|JAK-STAT cascade;GO:0043066|negative regulation of apoptotic process;GO:0050728|negative regulation of inflammatory response;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0046426|negative regulation of JAK-STAT cascade;GO:0006469|negative regulation of protein kinase activity;GO:0042532|negative regulation of tyrosine phosphorylation of STAT protein;GO:0060674|placenta blood vessel development;GO:0045597|positive regulation of cell differentiation;GO:0016567|protein ubiquitination;GO:0040008|regulation of growth;GO:0060708|spongiotrophoblast differentiation;GO:0060707|trophoblast giant cell differentiation;","GO:0005737|cytoplasm;","GO:0001784|phosphotyrosine binding;GO:0004860|protein kinase inhibitor activity;","K04696","SOCS3, CIS3; suppressor of cytokine signaling 3"]
["gene25068",4256,2225,2832,2708.15279858773,851,695,888,893.676930141479,3.03034878404995,1.59948385312407,{"v":5.50146471271891e-11,"d":"5.50E-11"},{"v":9.57087132430385e-09,"d":"9.57E-09"},"up","yes","SEC14L1","protein_coding","chrNC_037346.1:54706306-54755668:-","gi|156120599|ref|NP_001095445.1|",3693,0,"SEC14-like protein 1 [Bos taurus]","gi|742187611|ref|XM_010856232.1|",4165,0,"PREDICTED: Bison bison bison SEC14-like 1 (S. cerevisiae) (SEC14L1), transcript variant X2, mRNA","A8Y5H7",1334,0,"SEC14-like protein 1",".",".",".",".","pfam04707","PRELI","PRELI-like family. This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.","GO:0015871|choline transport;GO:0045087|innate immune response;GO:0039536|negative regulation of RIG-I signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005794|Golgi apparatus;GO:0005654|nucleoplasm;","GO:0098772|molecular function regulator;GO:0039552|RIG-I binding;",".","."]
["gene25096",1418,1807,2078,1599.94835079769,262,600,482,492.108713256569,3.25120914890919,1.70097636697522,0.000169000351691155,0.00446872014281775,"up","yes","UBALD2","protein_coding","chrNC_037346.1:55443314-55449222:-","gi|528921821|ref|XP_005195918.1|",807,{"v":3e-102,"d":"3.00E-102"},"PREDICTED: UBA-like domain-containing protein 2 isoform X1 [Bos taurus]","gi|741897083|ref|XM_005195861.2|",1584,0,"PREDICTED: Bos taurus UBA-like domain containing 2 (UBALD2), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam09770","PAT1","Topoisomerase II-associated protein PAT1. Members of this family are necessary for accurate chromosome transmission during cell division.",".",".",".",".","."]
["gene25097",4014,7983,6772,5742.13960856084,2268,2682,2521,2741.97934035963,2.09415859705482,1.06637070612743,{"v":5.4184549624057e-05,"d":"5.42E-05"},0.00173896443793472,"up","yes","RNF157","protein_coding","chrNC_037346.1:55465042-55539899:+","gi|296476015|tpg|DAA18130.1|",3080,0,"TPA: ring finger protein 157-like [Bos taurus]","gi|742187501|ref|XM_010856206.1|",4639,0,"PREDICTED: Bison bison bison ring finger protein 157 (RNF157), transcript variant X2, mRNA","Q96PX1",1077,0,"E3 ubiquitin ligase RNF157",".",".",".",".","pfam13920","zf-C3HC4_3","Zinc finger, C3HC4 type (RING finger).",".","GO:0005737|cytoplasm;","GO:0046872|metal ion binding;GO:0016740|transferase activity;",".","."]
["gene25137",266,180,197,188.817925076415,76,82,75,85.5723221451787,2.20653033998626,1.14177958463399,0.00146147349254622,0.0243621431678965,"up","yes","SLC25A19","protein_coding","chrNC_037346.1:56205905-56217714:+","gi|114052681|ref|NP_001039352.1|",1687,0,"mitochondrial thiamine pyrophosphate carrier [Bos taurus]","gi|982958525|ref|XM_005221149.3|",2451,0,"PREDICTED: Bos taurus solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 (SLC25A19), transcript variant X2, mRNA","Q29RM1",654,0,"Mitochondrial thiamine pyrophosphate carrier",".",".",".",".","pfam00153","Mito_carr","Mitochondrial carrier protein.","GO:0006839|mitochondrial transport;GO:0030974|thiamine pyrophosphate transport;","GO:0031305|integral component of mitochondrial inner membrane;","GO:0015234|thiamine transmembrane transporter activity;","K15108","SLC25A19, DNC, TPC1; solute carrier family 25 (mitochondrial thiamine pyrophosphate transporter), member 19"]
["gene25148",360,924,859,660.452984117286,224,321,290,306.209199498466,2.15686852386874,1.10893823688612,0.000104025419592638,0.00298817717791755,"up","yes","SLC16A5","protein_coding","chrNC_037346.1:56338722-56359950:-","gi|741965015|ref|XP_010814925.1|",2414,0,"PREDICTED: LOW QUALITY PROTEIN: monocarboxylate transporter 6 [Bos taurus]","gi|742187296|ref|XM_010856143.1|",2522,0,"PREDICTED: Bison bison bison solute carrier family 16 (monocarboxylate transporter), member 5 (SLC16A5), transcript variant X4, mRNA","O15375",679,0,"Monocarboxylate transporter 6",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0015718|monocarboxylic acid transport;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;","GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0015293|symporter activity;","K08182","SLC16A5; MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 5"]
["gene25184",688,1519,1323,1083.43386292164,343,468,524,489.102430769974,2.21514716501415,1.14740254852445,{"v":3.3972429450826e-05,"d":"3.40E-05"},0.00116922948335355,"up","yes","GPRC5C","protein_coding","chrNC_037346.1:56974300-56987901:-","gi|440891458|gb|ELR45129.1|",2055,0,"G-protein coupled receptor family C group 5 member C, partial [Bos mutus]","gi|439253393|ref|NM_001272010.1|",2101,0,"Bos taurus G protein-coupled receptor, class C, group 5, member C (GPRC5C), mRNA","Q2YDG0",776,0,"G-protein coupled receptor family C group 5 member C",".",".",".",".","pfam00003","7tm_3","7 transmembrane sweet-taste receptor of 3 GCPR. This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.",".","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;","K04620","GPRC5C; G protein-coupled receptor family C group 5 member C"]
["gene25198",2059,3649,5404,3392.15036408879,1029,1651,1593,1565.53365250783,2.1667693688059,1.11554560096859,0.000702526775126701,0.0138615431681465,"up","yes","RPL38","protein_coding","chrNC_037346.1:57192440-57196471:-","gi|556780507|ref|XP_005985284.1|",224,{"v":2e-27,"d":"2.00E-27"},"PREDICTED: uncharacterized protein LOC102319821 [Pantholops hodgsonii]","gi|982958765|ref|XM_015458985.1|",387,0,"PREDICTED: Bos taurus ribosomal protein L38 (RPL38), transcript variant X1, mRNA","P63174",97.1,{"v":3e-25,"d":"3.00E-25"},"60S ribosomal protein L38",".",".",".",".","pfam01781","Ribosomal_L38e","Ribosomal L38e protein family.","GO:0022618|ribonucleoprotein complex assembly;GO:0006412|translation;","GO:0022625|cytosolic large ribosomal subunit;","GO:0003723|RNA binding;GO:0003735|structural constituent of ribosome;","K02923","RP-L38e, RPL38; large subunit ribosomal protein L38e"]
["gene25203",1176,555,649,687.698178690701,220,354,290,316.824716914378,2.17059510188579,1.11809063383856,0.000223679640686792,0.00548736356701192,"up","yes","CDC42EP4","protein_coding","chrNC_037346.1:58037571-58058068:+","gi|114050763|ref|NP_001039936.1|",932,{"v":6e-113,"d":"6.00E-113"},"cdc42 effector protein 4 [Bos taurus]","gi|982958742|ref|XM_010816568.2|",3094,0,"PREDICTED: Bos taurus CDC42 effector protein 4 (CDC42EP4), transcript variant X2, mRNA","Q9H3Q1",289,{"v":1e-86,"d":"1.00E-86"},"Cdc42 effector protein 4",".",".",".",".","pfam14957","BORG_CEP","Cdc42 effector. The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organisation of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.","GO:0071346|cellular response to interferon-gamma;GO:0030838|positive regulation of actin filament polymerization;GO:0031274|positive regulation of pseudopodium assembly;GO:0008360|regulation of cell shape;GO:0007266|Rho protein signal transduction;","GO:0015629|actin cytoskeleton;GO:0005913|cell-cell adherens junction;GO:0005737|cytoplasm;GO:0012505|endomembrane system;GO:0015630|microtubule cytoskeleton;GO:0045335|phagocytic vesicle;GO:0005886|plasma membrane;","GO:0017049|GTP-Rho binding;GO:0005096|GTPase activator activity;GO:0003723|RNA binding;",".","."]
["gene25209",24,4,12,11.2512880041927,1,0,1,0.734740978638126,15.3132713858528,3.93671061469329,0.00285376367264256,0.0398285592219539,"up","yes","SSTR2","protein_coding","chrNC_037346.1:58152482-58159564:-","gi|528997113|ref|XP_005221197.1|",1924,0,"PREDICTED: somatostatin receptor type 2 isoform X1 [Bos taurus]","gi|982958518|ref|XM_005221140.3|",2651,0,"PREDICTED: Bos taurus somatostatin receptor 2 (SSTR2), transcript variant X1, mRNA","P34993",742,0,"Somatostatin receptor type 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0071392|cellular response to estradiol stimulus;GO:0071385|cellular response to glucocorticoid stimulus;GO:0007187|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0008285|negative regulation of cell proliferation;","GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;GO:0043005|neuron projection;","GO:0042923|neuropeptide binding;GO:0004994|somatostatin receptor activity;","K04218","SSTR2; somatostatin receptor 2"]
["gene25250",1167,338,361,525.786802692211,170,180,137,179.051623467624,2.936509552438,1.55410233091639,{"v":1.63845798278402e-07,"d":"1.64E-07"},{"v":1.29134930129312e-05,"d":"1.29E-05"},"up","yes","ARSG","protein_coding","chrNC_037346.1:61781773-61886526:-","gi|594076419|ref|XP_006061961.1|",1926,0,"PREDICTED: arylsulfatase G isoform X2 [Bubalus bubalis]","gi|156120582|ref|NM_001101967.1|",1633,0,"Bos taurus arylsulfatase G (ARSG), mRNA","Q32KH9",632,0,"Arylsulfatase G","SMa0943",132,{"v":2e-31,"d":"2.00E-31"},"COG3119","pfam00884","Sulfatase","Sulfatase.","GO:0006790|sulfur compound metabolic process;","GO:0005783|endoplasmic reticulum;GO:0005615|extracellular space;GO:0005764|lysosome;","GO:0004065|arylsulfatase activity;GO:0046872|metal ion binding;","K12381","ARSG; arylsulfatase G [EC:3.1.6.-]"]
["gene25251",1084,1920,2997,1832.17706873059,113,121,125,131.76290109527,13.9051057126151,3.79754280760403,{"v":9.82414545787103e-47,"d":"9.82E-47"},{"v":4.67154490097531e-43,"d":"4.67E-43"},"up","yes","SLC16A6","protein_coding","chrNC_037346.1:61867803-61877805:+","gi|300793651|ref|NP_001179601.1|",2346,0,"monocarboxylate transporter 7 [Bos taurus]","gi|300793650|ref|NM_001192672.1|",1888,0,"Bos taurus solute carrier family 16, member 6 (monocarboxylic acid transporter 7) (SLC16A6), mRNA","B1AT66",711,0,"Monocarboxylate transporter 7",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0015718|monocarboxylic acid transport;","GO:0005887|integral component of plasma membrane;","GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0015293|symporter activity;","K08183","SLC16A6; MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 6"]
["gene25268",1556,5563,6156,4119.26398243489,1024,1580,1490,1500.42848714797,2.74539174490403,1.45701202467891,{"v":1.15709340830412e-06,"d":"1.16E-06"},{"v":6.93551093116068e-05,"d":"6.94E-05"},"up","yes","CACNG1","protein_coding","chrNC_037346.1:63125526-63133136:+","gi|122692393|ref|NP_001073806.1|",868,{"v":4e-112,"d":"4.00E-112"},"voltage-dependent calcium channel gamma-1 subunit [Bos taurus]","gi|122692392|ref|NM_001080337.1|",1256,0,"Bos taurus calcium channel, voltage-dependent, gamma subunit 1 (CACNG1), mRNA","Q08DE1",338,{"v":1e-113,"d":"1.00E-113"},"Voltage-dependent calcium channel gamma-1 subunit",".",".",".",".","pfam13903","Claudin_2","PMP-22/EMP/MP20/Claudin tight junction. Members of this family are claudins, that form tight junctions between cells.","GO:0034765|regulation of ion transmembrane transport;GO:0070296|sarcoplasmic reticulum calcium ion transport;","GO:0005891|voltage-gated calcium channel complex;","GO:0005245|voltage-gated calcium channel activity;","K04866","CACNG1; voltage-dependent calcium channel gamma-1"]
["gene25292",0,19,3,7.14800080574955,0,0,0,0,"Inf","Inf",0.00371411403739803,0.0482926059940294,"up","yes","SPZ1","protein_coding","chrNC_037347.1:276052-283737:+","gi|94966881|ref|NP_001035630.1|",1836,0,"spermatogenic leucine zipper protein 1 [Bos taurus]","gi|402743394|ref|NM_001040540.2|",1544,0,"Bos taurus spermatogenic leucine zipper 1 (SPZ1), mRNA","Q32L17",711,0,"Spermatogenic leucine zipper protein 1",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;","K17482","SPZ1; spermatogenic leucine zipper protein 1"]
["gene25374",440,148,170,215.387118443886,44,92,66,74.0328629530777,2.90934471331196,1.54069424409113,0.000742734397147887,0.0143963843977215,"up","yes","ARHGEF28","protein_coding","chrNC_037347.1:7682926-8027701:-","gi|742177334|ref|XP_010851841.1|",7669,0,"PREDICTED: rho guanine nucleotide exchange factor 28 isoform X2 [Bison bison bison]","gi|742177347|ref|XM_010853544.1|",5315,0,"PREDICTED: Bison bison bison Rho guanine nucleotide exchange factor (GEF) 28 (ARHGEF28), transcript variant X6, mRNA","Q8N1W1",2395,0,"Rho guanine nucleotide exchange factor 28",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0030154|cell differentiation;GO:0048013|ephrin receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0035023|regulation of Rho protein signal transduction;","GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046872|metal ion binding;GO:0005089|Rho guanyl-nucleotide exchange factor activity;GO:0003723|RNA binding;",".","."]
["gene25392",844,313,378,438.633622985288,147,83,132,133.05229875913,3.29670082423276,1.72102296830041,{"v":3.55852321412955e-06,"d":"3.56E-06"},0.000175773218568433,"up","yes","ZNF366","protein_coding","chrNC_037347.1:9113103-9174688:+","gi|300796153|ref|NP_001179214.1|",3316,0,"zinc finger protein 366 [Bos taurus]","gi|965869149|ref|XM_012148225.2|",3282,0,"PREDICTED: Ovis aries musimon zinc finger protein 366 (ZNF366), transcript variant X1, mRNA","Q8N895",1153,0,"Zinc finger protein 366",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0043627|response to estrogen;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0030331|estrogen receptor binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003714|transcription corepressor activity;",".","."]
["gene25410",404,124,162,195.682484547959,67,84,66,79.6936284754145,2.45543449697897,1.29597833662645,0.000324695546933228,0.00746485789649632,"up","yes","MARVELD2","protein_coding","chrNC_037347.1:10317617-10341153:-","gi|555954488|ref|XP_005889411.1|",2591,0,"PREDICTED: MARVEL domain-containing protein 2 isoform X1 [Bos mutus]","gi|983002989|ref|XM_005196131.3|",3722,0,"PREDICTED: Bos taurus MARVEL domain containing 2 (MARVELD2), transcript variant X2, mRNA","Q8N4S9",887,0,"MARVEL domain-containing protein 2",".",".",".",".","pfam07303","Occludin_ELL","Occludin homology domain. This domain represents a conserved region approximately 100 residues long within eukaryotic occludin proteins and the RNA polymerase II elongation factor ELL. Occludin is an integral membrane protein that localizes to tight junctions, while ELL is an elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by polymerase at multiple sites along the DNA. This shared domain is thought to mediate protein interactions.","GO:0070830|bicellular tight junction assembly;GO:0045216|cell-cell junction organization;GO:0061028|establishment of endothelial barrier;GO:0007605|sensory perception of sound;","GO:0016324|apical plasma membrane;GO:0016323|basolateral plasma membrane;GO:0005923|bicellular tight junction;GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0031410|cytoplasmic vesicle;GO:0016021|integral component of membrane;GO:0061689|tricellular tight junction;",".","K17291","MARVELD2; MARVEL domain-containing protein 2"]
["gene25482",550,89,160,221.649115086599,43,29,49,44.4023389128527,4.99183422570653,2.31957002440003,{"v":7.88376434560685e-10,"d":"7.88E-10"},{"v":1.07454777232584e-07,"d":"1.07E-07"},"up","yes","ELOVL7","protein_coding","chrNC_037347.1:18454638-18531446:+","gi|118151176|ref|NP_001071510.1|",1500,0,"elongation of very long chain fatty acids protein 7 [Bos taurus]","gi|118151175|ref|NM_001078042.1|",3538,0,"Bos taurus ELOVL fatty acid elongase 7 (ELOVL7), mRNA","A0JNC4",582,0,"Elongation of very long chain fatty acids protein 7",".",".",".",".","pfam01151","ELO","GNS1/SUR4 family. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.","GO:0034625|fatty acid elongation, monounsaturated fatty acid;GO:0034626|fatty acid elongation, polyunsaturated fatty acid;GO:0019367|fatty acid elongation, saturated fatty acid;GO:0030148|sphingolipid biosynthetic process;GO:0042761|very long-chain fatty acid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0009922|fatty acid elongase activity;","K10250","ELOVL7; elongation of very long chain fatty acids protein 7 [EC:2.3.1.199]"]
["gene25523",0,30,0,9.83153037619775,0,1,0,0.366987568989444,26.7898185305577,4.74361290354241,0.00311336801606352,0.0423593242090168,"up","yes","DDX4","protein_coding","chrNC_037347.1:23358628-23424697:-","gi|296475821|tpg|DAA17936.1|",3629,0,"TPA: probable ATP-dependent RNA helicase DDX4 [Bos taurus]","gi|985567483|ref|NM_001319794.1|",2461,0,"Bubalus bubalis DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 (DDX4), mRNA","Q5W5U4",1403,0,"Probable ATP-dependent RNA helicase DDX4",".",".",".",".","pfam00270","DEAD","DEAD/DEAH box helicase. Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolizm, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.","GO:0030154|cell differentiation;GO:0043046|DNA methylation involved in gamete generation;GO:0031047|gene silencing by RNA;GO:0007141|male meiosis I;GO:0007140|male meiosis;GO:0007275|multicellular organismal development;GO:0010529|negative regulation of transposition;GO:1990511|piRNA biosynthetic process;GO:0034587|piRNA metabolic process;GO:0010501|RNA secondary structure unwinding;GO:0007283|spermatogenesis;","GO:0033391|chromatoid body;GO:0005737|cytoplasm;GO:0005730|nucleolus;GO:0043186|P granule;GO:0048471|perinuclear region of cytoplasm;GO:0071546|pi-body;GO:0071547|piP-body;","GO:0005524|ATP binding;GO:0004004|ATP-dependent RNA helicase activity;GO:0016887|ATPase activity;GO:0003676|nucleic acid binding;","K13982","DDX4, VASA; probable ATP-dependent RNA helicase DDX4 [EC:3.6.4.13]"]
["gene25567",12,71,67,46.9725835174454,2,2,1,1.8424842068019,25.4941580199367,4.67209478662827,{"v":2.89125478530503e-09,"d":"2.89E-09"},{"v":3.40869381320404e-07,"d":"3.41E-07"},"up","yes","HCN1","protein_coding","chrNC_037347.1:29111349-29562326:+","gi|330864796|ref|NP_001193509.1|",3710,0,"potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 [Bos taurus]","gi|330864795|ref|NM_001206580.1|",3225,0,"Bos taurus hyperpolarization activated cyclic nucleotide gated potassium channel 1 (HCN1), mRNA","O60741",1382,0,"Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1","mll3241_2",65.5,{"v":4e-11,"d":"4.00E-11"},"COG0664","pfam08412","Ion_trans_N","Ion transport protein N-terminal. This metazoan domain is found to the N-terminus of pfam00520 in voltage- and cyclic nucleotide-gated K/Na ion channels.","GO:0045176|apical protein localization;GO:0071320|cellular response to cAMP;GO:0071805|potassium ion transmembrane transport;GO:0051289|protein homotetramerization;GO:0034765|regulation of ion transmembrane transport;GO:0042391|regulation of membrane potential;GO:0046549|retinal cone cell development;GO:0035725|sodium ion transmembrane transport;","GO:0030424|axon;GO:0030425|dendrite;GO:0098855|HCN channel complex;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0030552|cAMP binding;GO:0042802|identical protein binding;GO:0005222|intracellular cAMP activated cation channel activity;GO:0005267|potassium channel activity;GO:0022843|voltage-gated cation channel activity;GO:0005249|voltage-gated potassium channel activity;GO:0005248|voltage-gated sodium channel activity;","K04954","HCN1; hyperpolarization activated cyclic nucleotide-gated potassium channel 1"]
["gene25572",133,398,725,387.757711189313,27,64,37,46.9349397230862,8.26160028066647,3.04642126026053,{"v":3.57752459738401e-07,"d":"3.58E-07"},{"v":2.50172436980302e-05,"d":"2.50E-05"},"up","yes","FGF10","protein_coding","chrNC_037347.1:30504441-30601752:+","gi|57163977|ref|NP_001009230.1|",974,{"v":3e-120,"d":"3.00E-120"},"fibroblast growth factor 10 precursor [Ovis aries]","gi|329744554|ref|NM_001206326.1|",3384,0,"Bos taurus fibroblast growth factor 10 (FGF10), mRNA","P70492",362,{"v":4e-115,"d":"4.00E-115"},"Fibroblast growth factor 10",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0031532|actin cytoskeleton reorganization;GO:0000187|activation of MAPK activity;GO:0001525|angiogenesis;GO:0001974|blood vessel remodeling;GO:0060667|branch elongation involved in salivary gland morphogenesis;GO:0060436|bronchiole morphogenesis;GO:0060449|bud elongation involved in lung branching;GO:0060447|bud outgrowth involved in lung branching;GO:0030154|cell differentiation;GO:0007368|determination of left/right symmetry;GO:0031076|embryonic camera-type eye development;GO:0048557|embryonic digestive tract morphogenesis;GO:0030538|embryonic genitalia morphogenesis;GO:0009880|embryonic pattern specification;GO:0010631|epithelial cell migration;GO:0060664|epithelial cell proliferation involved in salivary gland morphogenesis;GO:0070371|ERK1 and ERK2 cascade;GO:0000132|establishment of mitotic spindle orientation;GO:0048807|female genitalia morphogenesis;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0060595|fibroblast growth factor receptor signaling pathway involved in mammary gland specification;GO:0031069|hair follicle morphogenesis;GO:0070384|Harderian gland development;GO:0050930|induction of positive chemotaxis;GO:0043616|keratinocyte proliferation;GO:0032808|lacrimal gland development;GO:0060174|limb bud formation;GO:0061115|lung proximal/distal axis specification;GO:0060430|lung saccule development;GO:0048808|male genitalia morphogenesis;GO:0060615|mammary gland bud formation;GO:0060915|mesenchymal cell differentiation involved in lung development;GO:0060496|mesenchymal-epithelial cell signaling involved in lung development;GO:0001823|mesonephros development;GO:0003338|metanephros morphogenesis;GO:0042693|muscle cell fate commitment;GO:0071157|negative regulation of cell cycle arrest;GO:0045596|negative regulation of cell differentiation;GO:0008285|negative regulation of cell proliferation;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0042475|odontogenesis of dentin-containing tooth;GO:0001759|organ induction;GO:0030916|otic vesicle formation;GO:0031016|pancreas development;GO:0021983|pituitary gland development;GO:0032781|positive regulation of ATPase activity;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0031659|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0045739|positive regulation of DNA repair;GO:0045740|positive regulation of DNA replication;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0048146|positive regulation of fibroblast proliferation;GO:0071338|positive regulation of hair follicle cell proliferation;GO:0051549|positive regulation of keratinocyte migration;GO:0010838|positive regulation of keratinocyte proliferation;GO:0050671|positive regulation of lymphocyte proliferation;GO:0045931|positive regulation of mitotic cell cycle;GO:0045747|positive regulation of Notch signaling pathway;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0046579|positive regulation of Ras protein signal transduction;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0050677|positive regulation of urothelial cell proliferation;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:0070352|positive regulation of white fat cell proliferation;GO:0060513|prostatic bud formation;GO:0034394|protein localization to cell surface;GO:0060019|radial glial cell differentiation;GO:0032925|regulation of activin receptor signaling pathway;GO:0060665|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling;GO:0046877|regulation of saliva secretion;GO:0008589|regulation of smoothened signaling pathway;GO:0032355|response to estradiol;GO:0032496|response to lipopolysaccharide;GO:0014070|response to organic cyclic compound;GO:0061033|secretion by lung epithelial cell involved in lung growth;GO:0060879|semicircular canal fusion;GO:0051145|smooth muscle cell differentiation;GO:0035019|somatic stem cell population maintenance;GO:0048536|spleen development;GO:0060661|submandibular salivary gland formation;GO:0070075|tear secretion;GO:0048538|thymus development;GO:0030878|thyroid gland development;GO:0042246|tissue regeneration;GO:0060510|Type II pneumocyte differentiation;GO:0050674|urothelial cell proliferation;GO:0050872|white fat cell differentiation;","GO:0009986|cell surface;GO:0031012|extracellular matrix;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0042056|chemoattractant activity;GO:0005104|fibroblast growth factor receptor binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0005111|type 2 fibroblast growth factor receptor binding;","K04358","FGF; fibroblast growth factor"]
["gene25601",609,2471,2643,1780.23241417895,365,310,375,385.556332474176,4.61730819658677,2.20705203276583,{"v":9.75651457919868e-18,"d":"9.76E-18"},{"v":5.06114759016577e-15,"d":"5.06E-15"},"up","yes","C7","protein_coding","chrNC_037347.1:33535885-33592915:-","gi|296475775|tpg|DAA17890.1|",4304,0,"TPA: complement component C7 precursor [Bos taurus]","gi|114051807|ref|NM_001045966.1|",3649,0,"Bos taurus complement component 7 (C7), mRNA","Q29RQ1",1625,0,"Complement component C7",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.","GO:0006957|complement activation, alternative pathway;GO:0006958|complement activation, classical pathway;GO:0019835|cytolysis;","GO:0005576|extracellular region;GO:0005579|membrane attack complex;",".","K03996","C7; complement component 7"]
["gene25603",9733,7990,13835,9404.1380219556,3265,3604,3856,3934.8874709673,2.38993823618641,1.25697333473365,{"v":2.27399890566758e-06,"d":"2.27E-06"},0.000121953877401507,"up","yes","RPL37","protein_coding","chrNC_037347.1:33653739-33656336:+","gi|594059539|ref|XP_006080949.1|",474,{"v":7e-59,"d":"7.00E-59"},"PREDICTED: LOW QUALITY PROTEIN: ribosomal protein L37 [Bubalus bubalis]","gi|942038271|ref|XM_005889715.2|",366,0,"PREDICTED: Bos mutus ribosomal protein L37 (RPL37), mRNA","P61928",177,{"v":1e-56,"d":"1.00E-56"},"60S ribosomal protein L37","YLR185w",116,{"v":2e-33,"d":"2.00E-33"},"COG2126","pfam01907","Ribosomal_L37e","Ribosomal protein L37e. This family includes ribosomal protein L37 from eukaryotes and archaebacteria. The family contains many conserved cysteines and histidines suggesting that this protein may bind to zinc.","GO:0006412|translation;","GO:0022625|cytosolic large ribosomal subunit;","GO:0019838|growth factor binding;GO:0046872|metal ion binding;GO:0003723|RNA binding;GO:0019843|rRNA binding;GO:0003735|structural constituent of ribosome;","K02922","RP-L37e, RPL37; large subunit ribosomal protein L37e"]
["gene2561",1262,2676,2362,1931.30033302647,678,814,889,873.047544137691,2.2121364935904,1.14544040571309,{"v":8.83376840487406e-06,"d":"8.83E-06"},0.000389545975826061,"up","yes","AHDC1","protein_coding","chrNC_037329.1:125715868-125780857:+","gi|803220443|ref|XP_011970529.1|",5069,0,"PREDICTED: AT-hook DNA-binding motif-containing protein 1 isoform X1 [Ovis aries musimon]","gi|330340350|ref|NM_001206409.1|",5892,0,"Bos taurus AT hook, DNA binding motif, containing 1 (AHDC1), mRNA","Q5TGY3",1861,0,"AT-hook DNA-binding motif-containing protein 1",".",".",".",".","pfam15240","Pro-rich","Proline-rich. This family includes several eukaryotic proline-rich proteins.",".",".","GO:0003677|DNA binding;",".","."]
["gene25729",6263,1503,1853,2693.93939122851,532,840,643,739.219749204926,3.64430116230795,1.86564218729993,{"v":6.69273961754072e-09,"d":"6.69E-09"},{"v":7.26047733946974e-07,"d":"7.26E-07"},"up","yes","MYO10","protein_coding","chrNC_037347.1:56234281-56495822:+","gi|296475667|tpg|DAA17782.1|",10015,0,"TPA: myosin-X [Bos taurus]","gi|31342121|ref|NM_174394.2|",7737,0,"Bos taurus myosin X (MYO10), mRNA","P79114",3858,0,"Unconventional myosin-X","YAL029c",521,{"v":4e-153,"d":"4.00E-153"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0030705|cytoskeleton-dependent intracellular transport;GO:0007018|microtubule-based movement;GO:0008360|regulation of cell shape;GO:0051489|regulation of filopodium assembly;GO:0007165|signal transduction;","GO:0005938|cell cortex;GO:0005829|cytosol;GO:0031527|filopodium membrane;GO:0032433|filopodium tip;GO:0030027|lamellipodium;GO:0016459|myosin complex;GO:0001726|ruffle;","GO:0051015|actin filament binding;GO:0030898|actin-dependent ATPase activity;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0060002|plus-end directed microfilament motor activity;","K12559","MYO10; myosin X"]
["gene25735",698,270,257,349.329052534738,138,139,193,172.259036006522,2.02792875563004,1.02000696905492,0.00108060144496824,0.0191852145777155,"up","yes","FBXL7","protein_coding","chrNC_037347.1:57226263-57707480:-","gi|359077523|ref|XP_002696492.2|",2448,0,"PREDICTED: F-box/LRR-repeat protein 7 [Bos taurus]","gi|983003243|ref|XM_015468379.1|",4341,0,"PREDICTED: Bos taurus F-box and leucine-rich repeat protein 7 (FBXL7), mRNA","Q9UJT9",922,0,"F-box/LRR-repeat protein 7",".",".",".",".","pfam12937","F-box-like","F-box-like. This is an F-box-like family.","GO:0051301|cell division;GO:0008283|cell proliferation;GO:0000086|G2/M transition of mitotic cell cycle;GO:0000278|mitotic cell cycle;GO:0010972|negative regulation of G2/M transition of mitotic cell cycle;GO:0043687|post-translational protein modification;GO:0000209|protein polyubiquitination;GO:0016567|protein ubiquitination;GO:0010265|SCF complex assembly;GO:0031146|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005813|centrosome;GO:0005829|cytosol;GO:0019005|SCF ubiquitin ligase complex;GO:0000151|ubiquitin ligase complex;","GO:0004842|ubiquitin-protein transferase activity;","K10273","FBXL7; F-box and leucine-rich repeat protein 7"]
["gene25776",1499,920,712,910.845100016514,215,348,267,304.451574615092,2.99175690310705,1.58099295298949,{"v":4.51155167779799e-07,"d":"4.51E-07"},{"v":3.07205443721371e-05,"d":"3.07E-05"},"up","yes","SEMA5A","protein_coding","chrNC_037347.1:63654415-64222832:+","gi|297487819|ref|XP_002696487.1|",5359,0,"PREDICTED: semaphorin-5A [Bos taurus]","gi|983003273|ref|XM_015468386.1|",10499,0,"PREDICTED: Bos taurus semaphorin 5A (SEMA5A), transcript variant X1, mRNA","Q13591",1955,0,"Semaphorin-5A",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0007413|axonal fasciculation;GO:0002043|blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0007155|cell adhesion;GO:0060326|cell chemotaxis;GO:0007267|cell-cell signaling;GO:0021536|diencephalon development;GO:0050919|negative chemotaxis;GO:0048843|negative regulation of axon extension involved in axon guidance;GO:0007162|negative regulation of cell adhesion;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:0007399|nervous system development;GO:0050918|positive chemotaxis;GO:0030836|positive regulation of actin filament depolymerization;GO:0045766|positive regulation of angiogenesis;GO:0048842|positive regulation of axon extension involved in axon guidance;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:2001028|positive regulation of endothelial cell chemotaxis;GO:0001938|positive regulation of endothelial cell proliferation;GO:0051897|positive regulation of protein kinase B signaling;GO:1990256|signal clustering;","GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0035373|chondroitin sulfate proteoglycan binding;GO:0043395|heparan sulfate proteoglycan binding;GO:0038191|neuropilin binding;GO:0030215|semaphorin receptor binding;GO:0045545|syndecan binding;","K06841","SEMA5; semaphorin 5"]
["gene25826",296,331,540,351.464712069275,122,166,161,164.636278495776,2.13479504809319,1.09409756994286,0.000437473191211121,0.00952063128790579,"up","yes","NKD2","protein_coding","chrNC_037347.1:71306561-71326942:-","gi|803240937|ref|XP_011980567.1|",1571,0,"PREDICTED: protein naked cuticle homolog 2-like [Ovis aries musimon]","gi|965819299|ref|XM_012125177.2|",1502,0,"PREDICTED: Ovis aries musimon protein naked cuticle homolog 2-like (LOC105608074), mRNA","Q969F2",505,{"v":6e-170,"d":"6.00E-170"},"Protein naked cuticle homolog 2",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0006887|exocytosis;GO:0048210|Golgi vesicle fusion to target membrane;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1903078|positive regulation of protein localization to plasma membrane;GO:0010954|positive regulation of protein processing;GO:0072659|protein localization to plasma membrane;GO:0016055|Wnt signaling pathway;","GO:0016323|basolateral plasma membrane;GO:0071944|cell periphery;GO:0031410|cytoplasmic vesicle;GO:0070382|exocytic vesicle;GO:0005886|plasma membrane;","GO:0051117|ATPase binding;GO:0005509|calcium ion binding;GO:0019838|growth factor binding;GO:0032036|myosin heavy chain binding;GO:0031625|ubiquitin protein ligase binding;","K03213","NKD; naked cuticle"]
["gene25932",37,2,4,11.5269816557854,0,1,1,0.727960457442686,15.8346260953232,3.98501089614726,0.00277875929793664,0.0390353429490055,"up","yes","GABRB3","protein_coding","chrNC_037348.1:3866344-4145779:-","gi|150247144|ref|NP_001092850.1|",2342,0,"gamma-aminobutyric acid receptor subunit beta-3 precursor [Bos taurus]","gi|150247143|ref|NM_001099380.1|",2994,0,"Bos taurus gamma-aminobutyric acid (GABA) A receptor, beta 3 (GABRB3), mRNA","P28472",889,0,"Gamma-aminobutyric acid receptor subunit beta-3",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0071420|cellular response to histamine;GO:1902476|chloride transmembrane transport;GO:0090102|cochlea development;GO:0007214|gamma-aminobutyric acid signaling pathway;GO:0060080|inhibitory postsynaptic potential;GO:0060119|inner ear receptor cell development;GO:0060384|innervation;GO:0043524|negative regulation of neuron apoptotic process;GO:0060021|palate development;GO:0007605|sensory perception of sound;GO:0007165|signal transduction;","GO:0030054|cell junction;GO:0034707|chloride channel complex;GO:0030659|cytoplasmic vesicle membrane;GO:1902711|GABA-A receptor complex;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0045211|postsynaptic membrane;","GO:0004890|GABA-A receptor activity;GO:0022851|GABA-gated chloride ion channel activity;GO:0042802|identical protein binding;","K05181","GABRB; gamma-aminobutyric acid receptor subunit beta"]
["gene25971",906,3575,2154,2069.25535452902,515,651,572,637.875966052598,3.24397761422852,1.69776386395933,{"v":4.36077574642277e-11,"d":"4.36E-11"},{"v":7.68007980377704e-09,"d":"7.68E-09"},"up","yes","ARRDC4","protein_coding","chrNC_037348.1:8736193-8748958:-","gi|300796255|ref|NP_001178963.1|",1992,0,"arrestin domain-containing protein 4 [Bos taurus]","gi|999809016|ref|NM_001192034.2|",2541,0,"Bos taurus arrestin domain containing 4 (ARRDC4), mRNA","Q8NCT1",739,0,"Arrestin domain-containing protein 4",".",".",".",".","pfam00339","Arrestin_N","Arrestin (or S-antigen), N-terminal domain. Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.","GO:0051443|positive regulation of ubiquitin-protein transferase activity;GO:0015031|protein transport;GO:0016567|protein ubiquitination;GO:0007165|signal transduction;","GO:0005769|early endosome;GO:0005768|endosome;GO:1903561|extracellular vesicle;GO:0005886|plasma membrane;","GO:1990756|protein binding, bridging involved in substrate recognition for ubiquitination;",".","."]
["gene25994",502,823,610,587.888711379745,256,230,284,282.608072275623,2.08022618266327,1.05674040089811,0.000177157140156032,0.00460753907547105,"up","yes","RGMA","protein_coding","chrNC_037348.1:13981528-14031532:+","gi|194676787|ref|XP_001787742.1|",1872,0,"PREDICTED: repulsive guidance molecule A [Bos taurus]","gi|983003475|ref|XM_001787690.6|",3298,0,"PREDICTED: Bos taurus repulsive guidance molecule family member a (RGMA), mRNA","Q96B86",689,0,"Repulsive guidance molecule A",".",".",".",".","pfam06534","RGM_C","Repulsive guidance molecule (RGM) C-terminus. This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but RGMA from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.","GO:0030509|BMP signaling pathway;GO:0048681|negative regulation of axon regeneration;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;","GO:0031225|anchored component of membrane;GO:0005783|endoplasmic reticulum;GO:0005886|plasma membrane;","GO:0015026|coreceptor activity;GO:1990459|transferrin receptor binding;","K06847","RGM; RGM domain family"]
["gene26016",343,612,652,490.200295021737,220,233,186,234.878040667518,2.08704182659476,1.0614595139698,0.000269354395110318,0.00640412520574374,"up","yes","NTRK3","protein_coding","chrNC_037348.1:18837386-19261976:-","gi|466082757|ref|XP_004284826.1|",3116,0,"PREDICTED: NT-3 growth factor receptor isoform X4 [Orcinus orca]","gi|965880729|ref|XM_012152936.2|",3967,0,"PREDICTED: Ovis aries musimon neurotrophic tyrosine kinase, receptor, type 3 (NTRK3), transcript variant X5, mRNA","Q5IFJ9",1017,0,"NT-3 growth factor receptor",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0030154|cell differentiation;GO:0007507|heart development;GO:0007399|nervous system development;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;","GO:0005887|integral component of plasma membrane;","GO:0005524|ATP binding;GO:0005030|neurotrophin receptor activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;",".","."]
["gene26017",266,327,339,280.603695892134,124,104,152,139.381829402721,2.01320141294297,1.00949151548724,0.00199627817250053,0.0307702931062197,"up","yes","MRPL46","protein_coding","chrNC_037348.1:19474872-19484145:-","gi|77736369|ref|NP_001029884.1|",1454,0,"39S ribosomal protein L46, mitochondrial [Bos taurus]","gi|77736368|ref|NM_001034712.1|",990,0,"Bos taurus mitochondrial ribosomal protein L46 (MRPL46), mRNA","Q3SZ22",564,0,"39S ribosomal protein L46, mitochondrial",".",".",".",".","pfam11788","MRP-L46","39S mitochondrial ribosomal protein L46. This is the L46 subunit of the mammalian mitochondrial ribosome, conserved from plants and fungi.",".","GO:0005743|mitochondrial inner membrane;GO:0005762|mitochondrial large ribosomal subunit;","GO:0016787|hydrolase activity;GO:0003735|structural constituent of ribosome;","K17427","MRPL46; large subunit ribosomal protein L46"]
["gene26033",173,44,69,80.6987905767136,0,10,9,6.91863168597362,11.6639812956537,3.54398840616268,0.000557017217134045,0.0114497537622849,"up","yes","LOC618633","protein_coding","chrNC_037348.1:19743032-19750627:-","gi|528998916|ref|XP_005221848.1|",1676,0,"PREDICTED: uncharacterized protein LOC618633 isoform X1 [Bos taurus]","gi|157074119|ref|NM_001103302.1|",2423,0,"Bos taurus myeloid-associated differentiation marker-like (LOC618633), mRNA","Q96S97",244,{"v":1e-71,"d":"1.00E-71"},"Myeloid-associated differentiation marker",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0061028|establishment of endothelial barrier;GO:0031579|membrane raft organization;GO:0030837|negative regulation of actin filament polymerization;GO:0010629|negative regulation of gene expression;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0090038|negative regulation of protein kinase C signaling;GO:0001933|negative regulation of protein phosphorylation;GO:0030335|positive regulation of cell migration;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:0072659|protein localization to plasma membrane;","GO:0005911|cell-cell junction;GO:0030864|cortical actin cytoskeleton;GO:0016021|integral component of membrane;GO:0045121|membrane raft;GO:0005886|plasma membrane;GO:0001726|ruffle;",".",".","."]
["gene2606",10968,5296,4902,6099.61873864459,1830,3336,2616,2852.5712113808,2.13828798184219,1.09645616643392,0.00232744606204363,0.034388588087088,"up","yes","TRIM63","protein_coding","chrNC_037329.1:127020871-127035930:+","gi|741918442|ref|XP_010800878.1|",1754,0,"PREDICTED: E3 ubiquitin-protein ligase TRIM63 isoform X1 [Bos taurus]","gi|982915557|ref|XM_010802576.2|",1758,0,"PREDICTED: Bos taurus tripartite motif containing 63, E3 ubiquitin protein ligase (TRIM63), transcript variant X1, mRNA","Q969Q1",640,0,"E3 ubiquitin-protein ligase TRIM63",".",".",".",".","pfam13923","zf-C3HC4_2","Zinc finger, C3HC4 type (RING finger).","GO:0006936|muscle contraction;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0014878|response to electrical stimulus involved in regulation of muscle adaptation;GO:0051384|response to glucocorticoid;GO:0070555|response to interleukin-1;GO:0007165|signal transduction;GO:0014732|skeletal muscle atrophy;","GO:0005737|cytoplasm;GO:0031430|M band;GO:0005874|microtubule;GO:0005634|nucleus;GO:0030018|Z disc;","GO:0031432|titin binding;GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K10655","TRIM63, MURF1; tripartite motif-containing protein 63 [EC:2.3.2.27]"]
["gene26094",91,104,55,74.6910430380264,21,24,22,24.5982350956005,3.03643910824257,1.60238043814326,0.00133144627672196,0.0227333894202001,"up","yes","SEMA4B","protein_coding","chrNC_037348.1:21573411-21617717:+","gi|594068740|ref|XP_006058290.1|",4235,0,"PREDICTED: semaphorin-4B isoform X1 [Bubalus bubalis]","gi|983003588|ref|XM_005196238.3|",3703,0,"PREDICTED: Bos taurus semaphorin 4B (SEMA4B), mRNA","Q9NPR2",1294,0,"Semaphorin-4B",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0030154|cell differentiation;GO:0050919|negative chemotaxis;GO:0007399|nervous system development;","GO:0005615|extracellular space;GO:0016021|integral component of membrane;",".","K06521","SEMA4; semaphorin 4"]
["gene26133",11407,12036,16761,12065.0049504266,3874,5729,4947,5336.18224329495,2.26098067875897,1.17694866357209,{"v":2.06050633358288e-05,"d":"2.06E-05"},0.000779423375016689,"up","yes","RPS17","protein_coding","chrNC_037348.1:22839050-22842498:-","gi|594100882|ref|XP_006073535.1|",789,{"v":2e-104,"d":"2.00E-104"},"PREDICTED: 40S ribosomal protein S17 [Bubalus bubalis]","gi|942030395|ref|XM_005887140.2|",493,0,"PREDICTED: Bos mutus ribosomal protein S17 (RPS17), transcript variant X2, mRNA","Q6QAP7",276,{"v":2e-94,"d":"2.00E-94"},"40S ribosomal protein S17","SPCC24B10.09",173,{"v":3e-54,"d":"3.00E-54"},"COG1383","pfam00833","Ribosomal_S17e","Ribosomal S17.","GO:0000028|ribosomal small subunit assembly;GO:0006412|translation;","GO:0098556|cytoplasmic side of rough endoplasmic reticulum membrane;GO:0022627|cytosolic small ribosomal subunit;","GO:0003735|structural constituent of ribosome;","K02962","RP-S17e, RPS17; small subunit ribosomal protein S17e"]
["gene26140",3222,5509,5075,4203.7670543965,1331,2005,1605,1812.65688982737,2.31911901142904,1.21357685741077,{"v":1.45729090242648e-05,"d":"1.46E-05"},0.000588090052858982,"up","yes","FSD2","protein_coding","chrNC_037348.1:23034849-23081841:-","gi|329664702|ref|NP_001192937.1|",3850,0,"fibronectin type III and SPRY domain-containing protein 2 [Bos taurus]","gi|742124562|ref|XM_010841105.1|",3976,0,"PREDICTED: Bison bison bison fibronectin type III and SPRY domain containing 2 (FSD2), mRNA",".",".",".",".",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.",".",".",".",".","."]
["gene26200",0,23,47,21.9722234013324,0,0,0,0,"Inf","Inf",{"v":3.36969076087606e-07,"d":"3.37E-07"},{"v":2.39752237153503e-05,"d":"2.40E-05"},"up","yes","LOC100299869","pseudogene","chrNC_037348.1:27228448-27229378:-","gi|77736039|ref|NP_001029718.1|",1236,{"v":6e-169,"d":"6.00E-169"},"ribosome biogenesis protein NSA2 homolog [Bos taurus]","gi|942038339|ref|XR_001351273.1|",897,0,"PREDICTED: Bos mutus ribosome biogenesis protein NSA2 homolog (LOC102275194), misc_RNA","Q3SX11",480,{"v":2e-170,"d":"2.00E-170"},"Ribosome biogenesis protein NSA2 homolog","SPCP1E11.08",330,{"v":5e-112,"d":"5.00E-112"},"COG2007","pfam01201","Ribosomal_S8e","Ribosomal protein S8e.","GO:0000460|maturation of 5.8S rRNA;GO:0000470|maturation of LSU-rRNA;","GO:0005730|nucleolus;GO:0030687|preribosome, large subunit precursor;",".","K14842","NSA2; ribosome biogenesis protein NSA2"]
["gene26248",65,93,436,181.323286813699,29,18,44,33.3278579491143,5.44059228440505,2.44376371751622,{"v":1.37456412253101e-05,"d":"1.37E-05"},0.000559453480455523,"up","yes","CIB2","protein_coding","chrNC_037348.1:30485734-30508513:-","gi|955494687|ref|XP_014636463.1|",837,{"v":3e-106,"d":"3.00E-106"},"PREDICTED: calcium and integrin-binding family member 2 isoform X1 [Ceratotherium simum simum]","gi|594100492|ref|XM_006073286.1|",994,0,"PREDICTED: Bubalus bubalis calcium and integrin binding family member 2 (CIB2), transcript variant X1, mRNA","C7A276",321,{"v":6e-106,"d":"6.00E-106"},"Calcium and integrin-binding family member 2 (Fragment)",".",".",".",".","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0071318|cellular response to ATP;GO:0007204|positive regulation of cytosolic calcium ion concentration;","GO:0032437|cuticular plate;GO:0005737|cytoplasm;GO:0001917|photoreceptor inner segment;GO:0001750|photoreceptor outer segment;GO:0042383|sarcolemma;GO:0032420|stereocilium;","GO:0005509|calcium ion binding;GO:0000287|magnesium ion binding;GO:0042803|protein homodimerization activity;",".","."]
["gene26260",120,689,591,438.581154856075,73,108,89,99.046315106695,4.42804110767397,2.14666861542617,{"v":1.11748300090935e-11,"d":"1.12E-11"},{"v":2.16890527203706e-09,"d":"2.17E-09"},"up","yes","CHRNA3","protein_coding","chrNC_037348.1:30977362-30991920:-","gi|440912781|gb|ELR62318.1|",2390,0,"Neuronal acetylcholine receptor subunit alpha-3, partial [Bos mutus]","gi|31340644|ref|NM_174719.2|",1576,0,"Bos taurus cholinergic receptor, nicotinic alpha 3 (CHRNA3), mRNA","Q07263",923,0,"Neuronal acetylcholine receptor subunit alpha-3",".",".",".",".","pfam02931","Neur_chan_LBD","Neurotransmitter-gated ion-channel ligand binding domain. This family is the extracellular ligand binding domain of these ion channels. This domain forms a pentameric arrangement in the known structure.","GO:0035095|behavioral response to nicotine;GO:0007399|nervous system development;GO:0007165|signal transduction;GO:0060084|synaptic transmission involved in micturition;","GO:0005892|acetylcholine-gated channel complex;GO:0030054|cell junction;GO:0045211|postsynaptic membrane;","GO:0015464|acetylcholine receptor activity;GO:0022848|acetylcholine-gated cation channel activity;GO:0022850|serotonin-gated cation channel activity;","K04805","CHRNA3; nicotinic acetylcholine receptor alpha-3"]
["gene26332",1543,563,485,735.600700131515,135,199,183,189.547256990802,3.88083009909877,1.9563652740012,{"v":3.47697738067204e-12,"d":"3.48E-12"},{"v":7.87314616253603e-10,"d":"7.87E-10"},"up","yes","SEMA7A","protein_coding","chrNC_037348.1:34234871-34258815:+","gi|741966839|ref|XP_010815390.1|",3340,0,"PREDICTED: semaphorin-7A isoform X1 [Bos taurus]","gi|742138000|ref|XM_010843361.1|",3076,0,"PREDICTED: Bison bison bison semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A), mRNA","O75326",1076,0,"Semaphorin-7A",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0048675|axon extension;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0007229|integrin-mediated signaling pathway;GO:0050919|negative chemotaxis;GO:0021988|olfactory lobe development;GO:0001649|osteoblast differentiation;GO:0045773|positive regulation of axon extension;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0060907|positive regulation of macrophage cytokine production;GO:0050727|regulation of inflammatory response;","GO:0031225|anchored component of membrane;GO:0009897|external side of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0005178|integrin binding;GO:0038191|neuropilin binding;","K06529","SEMA7, CD108; semaphorin 7"]
["gene26434",4124,4971,4323,4031.58163413633,1331,1157,1341,1406.15458877266,2.86709702213839,1.5195907259909,{"v":8.65851053959214e-10,"d":"8.66E-10"},{"v":1.16526398209954e-07,"d":"1.17E-07"},"up","yes","NFKBIA","protein_coding","chrNC_037348.1:45639614-45643009:-","gi|926719503|ref|XP_013828581.1|",1687,0,"PREDICTED: NF-kappa-B inhibitor alpha [Capra hircus]","gi|114052816|ref|NM_001045868.1|",1573,0,"Bos taurus nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA), mRNA","Q08353",599,0,"NF-kappa-B inhibitor alpha","all2748",71.2,{"v":2e-12,"d":"2.00E-12"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0007253|cytoplasmic sequestering of NF-kappaB;GO:0042994|cytoplasmic sequestering of transcription factor;GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0010888|negative regulation of lipid storage;GO:0010745|negative regulation of macrophage derived foam cell differentiation;GO:0045638|negative regulation of myeloid cell differentiation;GO:0045746|negative regulation of Notch signaling pathway;GO:0070427|nucleotide-binding oligomerization domain containing 1 signaling pathway;GO:0070431|nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0032270|positive regulation of cellular protein metabolic process;GO:0010875|positive regulation of cholesterol efflux;GO:0050729|positive regulation of inflammatory response;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0000060|protein import into nucleus, translocation;GO:0042127|regulation of cell proliferation;GO:0043330|response to exogenous dsRNA;GO:0032496|response to lipopolysaccharide;GO:0032495|response to muramyl dipeptide;GO:0035994|response to muscle stretch;GO:0034142|toll-like receptor 4 signaling pathway;GO:0033209|tumor necrosis factor-mediated signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0042802|identical protein binding;GO:0051059|NF-kappaB binding;GO:0008139|nuclear localization sequence binding;GO:0031625|ubiquitin protein ligase binding;","K04734","NFKBIA; NF-kappa-B inhibitor alpha"]
["gene26492",50,9,33,26.1156348637373,4,8,2,5.15291868956157,5.06812477298362,2.34145204285852,0.00241208580223241,0.0352376958645637,"up","yes","MIS18BP1","protein_coding","chrNC_037348.1:54918398-54965809:-","gi|346644856|ref|NP_001231100.1|",5362,0,"mis18-binding protein 1 [Bos taurus]","gi|742102099|ref|XM_010836128.1|",4168,0,"PREDICTED: Bison bison bison MIS18 binding protein 1 (MIS18BP1), transcript variant X1, mRNA","Q80WQ8",880,0,"Mis18-binding protein 1",".",".",".",".","pfam09133","SANTA","SANTA (SANT Associated). The SANTA domain (SANT Associated domain) is approximately 90 amino acids in length and is conserved in Eukaryota. It is sometimes found in association with the SANT domain (pfam00249, also known as Myb-like DNA-binding domain) implying a putative function in regulating chromatin remodelling. Sequence analysis has showed that the SANTA domain is likely to form four central beta-sheets with three flanking alpha- helixes. Many conserved hydrophobic residues are present which implying a possible role in protein-protein interactions.","GO:0007049|cell cycle;GO:0051301|cell division;","GO:0000778|condensed nuclear chromosome kinetochore;","GO:0003677|DNA binding;",".","."]
["gene26524",1292,2053,1950,1608.41680293932,218,254,305,284.793017161862,5.64766938097073,2.49765563457312,{"v":4.47568071190919e-23,"d":"4.48E-23"},{"v":5.10782585565924e-20,"d":"5.11E-20"},"up","yes","CCDC88C","protein_coding","chrNC_037348.1:56040120-56056237:-","gi|555961155|ref|XP_005892674.1|",2535,0,"PREDICTED: protein Daple [Bos mutus]","gi|156120680|ref|NM_001102017.1|",3288,0,"Bos taurus coiled-coil domain containing 88C (CCDC88C), mRNA","Q9P219",707,0,"Protein Daple",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.","GO:0031122|cytoplasmic microtubule organization;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0031648|protein destabilization;GO:0051260|protein homooligomerization;GO:0001932|regulation of protein phosphorylation;GO:0031098|stress-activated protein kinase signaling cascade;GO:0016055|Wnt signaling pathway;","GO:0005813|centrosome;GO:0005737|cytoplasm;","GO:0051959|dynein light intermediate chain binding;GO:0008017|microtubule binding;GO:0030165|PDZ domain binding;GO:0043621|protein self-association;",".","."]
["gene26561",15971,44849,33107,29028.099834111,9709,15123,11856,13458.561958934,2.15685003514374,1.10892587001911,0.000966882495022785,0.0175931916234025,"up","yes","ASB2","protein_coding","chrNC_037348.1:58530359-58579232:-","gi|296475217|tpg|DAA17332.1|",3239,0,"TPA: ankyrin repeat and SOCS box protein 2 [Bos taurus]","gi|77736282|ref|NM_001034669.1|",2605,0,"Bos taurus ankyrin repeat and SOCS box containing 2 (ASB2), mRNA","Q3SX45",1249,0,"Ankyrin repeat and SOCS box protein 2","all2748",134,{"v":1e-32,"d":"1.00E-32"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0035556|intracellular signal transduction;GO:0016567|protein ubiquitination;","GO:0005622|intracellular;",".","K10324","ASB2; ankyrin repeat and SOCS box protein 2"]
["gene26624",263,162,137,163.709839123701,54,53,46,56.2385708952734,2.91098860653054,1.54150919283269,{"v":5.23880409861904e-05,"d":"5.24E-05"},0.00168700135144131,"up","yes","CCDC85C","protein_coding","chrNC_037348.1:64523705-64601592:-","gi|982960915|ref|XP_015314852.1|",1361,{"v":2e-171,"d":"2.00E-171"},"PREDICTED: coiled-coil domain-containing protein 85C [Bos taurus]","gi|983004059|ref|XM_015468600.1|",3140,0,"PREDICTED: Bos taurus coiled-coil domain containing 85C (CCDC85C), mRNA","E9Q6B2",479,{"v":2e-154,"d":"2.00E-154"},"Coiled-coil domain-containing protein 85C",".",".",".",".","pfam10226","DUF2216","Uncharacterized conserved proteins (DUF2216). This is the conserved N-terminal half of a proteins which are found from worms to humans. some annotation suggests it might be PKR, the Hepatitis delta antigen-interacting protein A, but this could not be confirmed.","GO:0021987|cerebral cortex development;","GO:0043296|apical junction complex;GO:0005923|bicellular tight junction;",".",".","."]
["gene26627",2209,3135,2847,2477.48694536612,1003,1054,1061,1144.6865268192,2.1643365998641,1.1139248860369,{"v":7.87452777110767e-06,"d":"7.87E-06"},0.000352697255631826,"up","yes","EML1","protein_coding","chrNC_037348.1:64706932-64908495:+","gi|742169784|ref|XP_010849669.1|",4211,0,"PREDICTED: echinoderm microtubule-associated protein-like 1 isoform X1 [Bison bison bison]","gi|742169783|ref|XM_010851367.1|",4000,0,"PREDICTED: Bison bison bison echinoderm microtubule associated protein like 1 (EML1), transcript variant X1, mRNA","O00423",1492,0,"Echinoderm microtubule-associated protein-like 1","all0284_3",82.8,{"v":3e-15,"d":"3.00E-15"},"COG2319","pfam03451","HELP","HELP motif. The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.","GO:0007420|brain development;GO:0002244|hematopoietic progenitor cell differentiation;GO:0000226|microtubule cytoskeleton organization;GO:0007052|mitotic spindle organization;GO:0007405|neuroblast proliferation;","GO:0005829|cytosol;GO:0005874|microtubule;GO:0005875|microtubule associated complex;GO:1990023|mitotic spindle midzone;GO:0097431|mitotic spindle pole;GO:0048471|perinuclear region of cytoplasm;","GO:0005509|calcium ion binding;GO:0008017|microtubule binding;GO:0015631|tubulin binding;","K18595","EML1_2; echinoderm microtubule-associated protein-like 1/2"]
["gene2674",1530,431,606,726.115582063954,302,304,315,338.148644071397,2.14732661152011,1.10254164391367,{"v":7.87237429514946e-05,"d":"7.87E-05"},0.00238943309590329,"up","yes","LUZP1","protein_coding","chrNC_037329.1:129665730-129768528:+","gi|329663351|ref|NP_001192757.1|",4796,0,"leucine zipper protein 1 [Bos taurus]","gi|982915529|ref|XM_010802562.2|",7698,0,"PREDICTED: Bos taurus leucine zipper protein 1 (LUZP1), transcript variant X6, mRNA","Q86V48",1519,0,"Leucine zipper protein 1",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0060840|artery development;GO:0021503|neural fold bending;GO:0003281|ventricular septum development;","GO:0070062|extracellular exosome;GO:0016020|membrane;GO:0005634|nucleus;",".",".","."]
["gene26769",2257,1596,1751,1649.03404200084,266,304,278,311.336995951971,5.2966209073824,2.4050722549802,{"v":6.83322152709845e-22,"d":"6.83E-22"},{"v":6.09245760592643e-19,"d":"6.09E-19"},"up","yes","ANKRD9","protein_coding","chrNC_037348.1:67248222-67254884:-","gi|156120935|ref|NP_001095614.1|",1261,{"v":3e-156,"d":"3.00E-156"},"ankyrin repeat domain-containing protein 9 [Bos taurus]","gi|594112855|ref|XM_006079140.1|",1661,0,"PREDICTED: Bubalus bubalis ankyrin repeat domain 9 (ANKRD9), mRNA","Q96BM1",467,{"v":2e-149,"d":"2.00E-149"},"Ankyrin repeat domain-containing protein 9",".",".",".",".","pfam13857","Ank_5","Ankyrin repeats (many copies).","GO:0043687|post-translational protein modification;","GO:0005829|cytosol;",".",".","."]
["gene26805",425,253,136,235.445990665359,82,93,107,103.402926375676,2.27697608682711,1.18711914013633,0.000447830407735832,0.00970163201451103,"up","yes","KIF26A","protein_coding","chrNC_037348.1:68662821-68702159:+","gi|803324395|ref|XP_012020387.1|",6069,0,"PREDICTED: kinesin-like protein KIF26A [Ovis aries musimon]","gi|983003934|ref|XM_015468566.1|",5427,0,"PREDICTED: Bos taurus kinesin family member 26A (KIF26A), transcript variant X2, mRNA","Q9ULI4",1806,0,"Kinesin-like protein KIF26A","YKL079w",79.3,{"v":8e-14,"d":"8.00E-14"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0048484|enteric nervous system development;GO:0007018|microtubule-based movement;GO:0009968|negative regulation of signal transduction;GO:0001560|regulation of cell growth by extracellular stimulus;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;","GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;","GO:0005524|ATP binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10404","KIF26; kinesin family member 26"]
["gene26811",5233,13962,13575,10108.6118116763,3417,3622,3840,3992.53043070196,2.5318809680053,1.34020958055412,{"v":1.40511477255555e-06,"d":"1.41E-06"},{"v":8.18149583179234e-05,"d":"8.18E-05"},"up","yes","ADSSL1","protein_coding","chrNC_037348.1:69197998-69216372:+","gi|529000048|ref|XP_005222315.1|",2036,0,"PREDICTED: adenylosuccinate synthetase isozyme 1 isoform X3 [Bos taurus]","gi|982960783|ref|XM_005222258.3|",1906,0,"PREDICTED: Bos taurus adenylosuccinate synthase like 1 (ADSSL1), transcript variant X3, mRNA","A5PJR4",713,0,"Adenylosuccinate synthetase isozyme 1","SPAC144.03",395,{"v":8e-133,"d":"8.00E-133"},"COG0104","pfam00709","Adenylsucc_synt","Adenylosuccinate synthetase.","GO:0044208|'de novo' AMP biosynthetic process;GO:0046040|IMP metabolic process;","GO:0005737|cytoplasm;","GO:0004019|adenylosuccinate synthase activity;GO:0005525|GTP binding;GO:0046872|metal ion binding;","K01939","purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]"]
["gene26824",585,712,706,602.627454471597,230,241,254,266.097778536103,2.26468427428015,1.17930993429809,{"v":2.50953482022223e-05,"d":"2.51E-05"},0.000906323265262789,"up","yes","JAG2","protein_coding","chrNC_037348.1:69505928-69527005:-","gi|803327780|ref|XP_012022054.1|",5445,0,"PREDICTED: protein jagged-2 isoform X1 [Ovis aries musimon]","gi|983004208|ref|XM_015468638.1|",4018,0,"PREDICTED: Bos taurus jagged 2 (JAG2), transcript variant X1, mRNA","Q9Y219",1973,0,"Protein jagged-2",".",".",".",".","pfam01414","DSL","Delta serrate ligand.","GO:0009912|auditory receptor cell fate commitment;GO:0030154|cell differentiation;GO:1990134|epithelial cell apoptotic process involved in palatal shelf morphogenesis;GO:0042492|gamma-delta T cell differentiation;GO:0001701|in utero embryonic development;GO:0016331|morphogenesis of embryonic epithelium;GO:0007219|Notch signaling pathway;GO:0042475|odontogenesis of dentin-containing tooth;GO:0045747|positive regulation of Notch signaling pathway;GO:0030155|regulation of cell adhesion;GO:0042127|regulation of cell proliferation;GO:0003016|respiratory system process;GO:0001501|skeletal system development;GO:0007283|spermatogenesis;GO:0030217|T cell differentiation;GO:0045061|thymic T cell selection;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0008083|growth factor activity;GO:0005112|Notch binding;",".","."]
["gene2685",2939,2603,2478,2380.06822011726,599,885,794,835.283558008278,2.84941346839449,1.51066498126918,{"v":1.83264231936594e-09,"d":"1.83E-09"},{"v":2.2350525272778e-07,"d":"2.24E-07"},"up","yes","ZBTB40","protein_coding","chrNC_037329.1:130293846-130374042:-","gi|528941072|ref|XP_005203266.1|",6307,0,"PREDICTED: zinc finger and BTB domain-containing protein 40 isoform X1 [Bos taurus]","gi|982915582|ref|XM_005203209.3|",7798,0,"PREDICTED: Bos taurus zinc finger and BTB domain containing 40 (ZBTB40), transcript variant X1, mRNA","Q9NUA8",2025,0,"Zinc finger and BTB domain-containing protein 40","SPAC144.09c",97.1,{"v":5e-20,"d":"5.00E-20"},"COG5048","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0030282|bone mineralization;GO:0006974|cellular response to DNA damage stimulus;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K10512","ZBTB40; zinc finger and BTB domain-containing protein 40"]
["gene26855",24462,85115,66800,54784.7810101777,5816,14142,9577,10820.8107658807,5.06290907358999,2.33996657465682,{"v":3.89927823261144e-05,"d":"3.90E-05"},0.00131346289556832,"up","yes","PGAM2","protein_coding","chrNC_037349.1:390223-392579:-","gi|440898595|gb|ELR50055.1|",1361,0,"Phosphoglycerate mutase 2, partial [Bos mutus]","gi|942080602|ref|XM_005904394.2|",848,0,"PREDICTED: Bos mutus phosphoglycerate mutase 2 (muscle) (PGAM2), mRNA","Q32KV0",523,0,"Phosphoglycerate mutase 2","STM0772",295,{"v":2e-98,"d":"2.00E-98"},"COG0588","pfam00300","His_Phos_1","Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.","GO:0006094|gluconeogenesis;GO:0006096|glycolytic process;GO:0043456|regulation of pentose-phosphate shunt;","GO:0005829|cytosol;","GO:0046538|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;GO:0004082|bisphosphoglycerate mutase activity;GO:0016787|hydrolase activity;","K01834","PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]"]
["gene26871",5566,1210,1521,2314.29933278825,776,916,856,935.197443693776,2.47466387808695,1.30723258404158,{"v":4.6633660972316e-07,"d":"4.66E-07"},{"v":3.1603443733994e-05,"d":"3.16E-05"},"up","yes","SLC4A7","protein_coding","chrNC_037349.1:1752646-1876268:-","gi|741968030|ref|XP_010815732.1|",5609,0,"PREDICTED: sodium bicarbonate cotransporter 3 isoform X2 [Bos taurus]","gi|982961163|ref|XM_015459416.1|",10730,0,"PREDICTED: Bos taurus solute carrier family 4, sodium bicarbonate cotransporter, member 7 (SLC4A7), transcript variant X6, mRNA","Q9R1N3",1964,0,"Sodium bicarbonate cotransporter 3",".",".",".",".","pfam00955","HCO3_cotransp","HCO3- transporter family. This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.","GO:0060117|auditory receptor cell development;GO:0051453|regulation of intracellular pH;","GO:0016324|apical plasma membrane;GO:0016323|basolateral plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0032420|stereocilium;GO:0045202|synapse;","GO:0005452|inorganic anion exchanger activity;GO:0008510|sodium:bicarbonate symporter activity;","K13858","SLC4A7; solute carrier family 4 (sodium bicarbonate cotransporter), member 7"]
["gene2688",40,244,182,146.284180516531,30,39,36,38.5205818804516,3.79755895096608,1.92507236041038,{"v":4.54965761875788e-06,"d":"4.55E-06"},0.000217430957321241,"up","yes","WNT4","protein_coding","chrNC_037329.1:130683545-130711677:+","gi|803221060|ref|XP_011970847.1|",1864,0,"PREDICTED: protein Wnt-4 isoform X2 [Ovis aries musimon]","gi|982977948|ref|XM_015462460.1|",3549,0,"PREDICTED: Bos taurus wingless-type MMTV integration site family member 4 (WNT4), transcript variant X5, mRNA","P56705",717,0,"Protein Wnt-4",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0030325|adrenal gland development;GO:0006702|androgen biosynthetic process;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0060070|canonical Wnt signaling pathway;GO:0045165|cell fate commitment;GO:0009267|cellular response to starvation;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0001838|embryonic epithelial tube formation;GO:0001837|epithelial to mesenchymal transition;GO:0008585|female gonad development;GO:0030237|female sex determination;GO:0033080|immature T cell proliferation in thymus;GO:0001822|kidney development;GO:0001889|liver development;GO:0008584|male gonad development;GO:0061180|mammary gland epithelium development;GO:0060231|mesenchymal to epithelial transition;GO:0072162|metanephric mesenchymal cell differentiation;GO:0072273|metanephric nephron morphogenesis;GO:0072174|metanephric tubule formation;GO:2001234|negative regulation of apoptotic signaling pathway;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0045596|negative regulation of cell differentiation;GO:0030336|negative regulation of cell migration;GO:0040037|negative regulation of fibroblast growth factor receptor signaling pathway;GO:0010629|negative regulation of gene expression;GO:2000019|negative regulation of male gonad development;GO:0010894|negative regulation of steroid biosynthetic process;GO:0061369|negative regulation of testicular blood vessel morphogenesis;GO:2000225|negative regulation of testosterone biosynthetic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0061045|negative regulation of wound healing;GO:0030182|neuron differentiation;GO:0038030|non-canonical Wnt signaling pathway via MAPK cascade;GO:0048599|oocyte development;GO:0061205|paramesonephric duct development;GO:0032349|positive regulation of aldosterone biosynthetic process;GO:0030501|positive regulation of bone mineralization;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0032967|positive regulation of collagen biosynthetic process;GO:2000066|positive regulation of cortisol biosynthetic process;GO:0061184|positive regulation of dermatome development;GO:0051894|positive regulation of focal adhesion assembly;GO:0043547|positive regulation of GTPase activity;GO:0045836|positive regulation of meiotic nuclear division;GO:0045669|positive regulation of osteoblast differentiation;GO:0051496|positive regulation of stress fiber assembly;GO:0045893|positive regulation of transcription, DNA-templated;GO:0072659|protein localization to plasma membrane;GO:0022407|regulation of cell-cell adhesion;GO:0072033|renal vesicle formation;GO:0072034|renal vesicle induction;GO:0051145|smooth muscle cell differentiation;GO:0060126|somatotropin secreting cell differentiation;GO:0060748|tertiary branching involved in mammary gland duct morphogenesis;GO:0060129|thyroid-stimulating hormone-secreting cell differentiation;GO:0016055|Wnt signaling pathway;","GO:0009986|cell surface;GO:0005737|cytoplasm;GO:0030666|endocytic vesicle membrane;GO:0005788|endoplasmic reticulum lumen;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005796|Golgi lumen;GO:0005886|plasma membrane;","GO:0005109|frizzled binding;GO:0048018|receptor agonist activity;GO:0003714|transcription corepressor activity;","K00408","WNT4; wingless-type MMTV integration site family, member 4"]
["gene26888",1744,2639,2861,2198.04887422133,639,687,617,713.678541699539,3.07988645558397,1.62287716488594,{"v":4.90516283432375e-11,"d":"4.91E-11"},{"v":8.58584054147796e-09,"d":"8.59E-09"},"up","yes","GADL1","protein_coding","chrNC_037349.1:5209242-5403422:-","gi|197382899|ref|NP_001095751.2|",2637,0,"acidic amino acid decarboxylase GADL1 [Bos taurus]","gi|982961375|ref|XM_010817523.2|",3508,0,"PREDICTED: Bos taurus glutamate decarboxylase like 1 (GADL1), transcript variant X2, mRNA","A6QM00",1020,0,"Acidic amino acid decarboxylase GADL1","BH2623",216,{"v":2e-59,"d":"2.00E-59"},"COG0076","pfam00282","Pyridoxal_deC","Pyridoxal-dependent decarboxylase conserved domain.","GO:0019752|carboxylic acid metabolic process;",".","GO:0004068|aspartate 1-decarboxylase activity;GO:0030170|pyridoxal phosphate binding;GO:0004782|sulfinoalanine decarboxylase activity;","K18966","GADL1, CSADC, ADC; sulfinoalanine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.29 4.1.1.11]"]
["gene2696",32441,29362,36564,29306.9203343141,12707,10198,13174,13247.4671830167,2.21226593200288,1.14552481944306,0.000390699248836561,0.0086612589499269,"up","yes","HSPG2","protein_coding","chrNC_037329.1:130867508-130977474:+","gi|528901306|ref|XP_005197670.1|",22334,0,"PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [Bos taurus]","gi|982977960|ref|XM_005197613.3|",14850,0,"PREDICTED: Bos taurus heparan sulfate proteoglycan 2 (HSPG2), transcript variant X1, mRNA","P98160",5160,0,"Basement membrane-specific heparan sulfate proteoglycan core protein",".",".",".",".","pfam00054","Laminin_G_1","Laminin G domain.","GO:0001525|angiogenesis;GO:0007420|brain development;GO:0072358|cardiovascular system development;GO:0030154|cell differentiation;GO:0044267|cellular protein metabolic process;GO:0030198|extracellular matrix organization;GO:0006024|glycosaminoglycan biosynthetic process;GO:0006027|glycosaminoglycan catabolic process;GO:0006954|inflammatory response;GO:0006629|lipid metabolic process;GO:0016525|negative regulation of angiogenesis;GO:0060548|negative regulation of cell death;GO:0006898|receptor-mediated endocytosis;GO:0001523|retinoid metabolic process;","GO:0005604|basement membrane;GO:0070062|extracellular exosome;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005925|focal adhesion;GO:0005796|Golgi lumen;GO:0043202|lysosomal lumen;GO:0005886|plasma membrane;GO:0098797|plasma membrane protein complex;","GO:0005509|calcium ion binding;GO:0005178|integrin binding;GO:0050750|low-density lipoprotein particle receptor binding;GO:0008022|protein C-terminus binding;","K06255","HSPG2; heparan sulfate proteoglycan 2 (perlecan)"]
["gene27011",195,252,198,194.216469797526,38,29,47,41.8115526850218,4.64504323148708,2.21569202385481,{"v":5.50419796842684e-09,"d":"5.50E-09"},{"v":6.08683225725528e-07,"d":"6.09E-07"},"up","yes","VIPR1","protein_coding","chrNC_037349.1:14658102-14689961:+","gi|296475060|tpg|DAA17175.1|",2339,0,"TPA: vasoactive intestinal peptide receptor 1 [Bos taurus]","gi|125991945|ref|NM_001081607.1|",2689,0,"Bos taurus vasoactive intestinal peptide receptor 1 (VIPR1), mRNA","Q28992",825,0,"Vasoactive intestinal polypeptide receptor 1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004999|vasoactive intestinal polypeptide receptor activity;","K04589","VIPR1; vasoactive intestinal peptide receptor 1"]
["gene2702",544,433,234,355.547258199649,59,113,84,93.8436352467877,3.78872000498104,1.92171052534378,{"v":1.77869007118313e-06,"d":"1.78E-06"},{"v":9.9915669277968e-05,"d":"9.99E-05"},"up","yes","ALPL","protein_coding","chrNC_037329.1:131181421-131268191:-","gi|982915351|ref|XP_015315483.1|",2741,0,"PREDICTED: alkaline phosphatase, tissue-nonspecific isozyme isoform X1 [Bos taurus]","gi|982915350|ref|XM_015459997.1|",2559,0,"PREDICTED: Bos taurus alkaline phosphatase, liver/bone/kidney (ALPL), transcript variant X1, mRNA","P09487",1036,0,"Alkaline phosphatase, tissue-nonspecific isozyme","XF0657",301,{"v":4e-90,"d":"4.00E-90"},"COG1785","pfam00245","Alk_phosphatase","Alkaline phosphatase.","GO:0031214|biomineral tissue development;GO:0071407|cellular response to organic cyclic compound;GO:0003006|developmental process involved in reproduction;GO:0001958|endochondral ossification;GO:0046677|response to antibiotic;GO:0033280|response to vitamin D;","GO:0031225|anchored component of membrane;GO:0065010|extracellular membrane-bounded organelle;GO:0005886|plasma membrane;","GO:0004035|alkaline phosphatase activity;GO:0046872|metal ion binding;GO:0016462|pyrophosphatase activity;","K01077","E3.1.3.1, phoA, phoB; alkaline phosphatase [EC:3.1.3.1]"]
["gene27060",1156,2119,2057,1627.46342435329,369,463,441,467.024713528214,3.48474797416683,1.80105432049327,{"v":1.18730988988923e-12,"d":"1.19E-12"},{"v":2.94566421464604e-10,"d":"2.95E-10"},"up","yes","IRAK2","protein_coding","chrNC_037349.1:16649507-16705570:-","gi|115496712|ref|NP_001069164.1|",2710,0,"interleukin-1 receptor-associated kinase-like 2 [Bos taurus]","gi|402744889|ref|NM_001075696.2|",2472,0,"Bos taurus interleukin 1 receptor associated kinase 2 (IRAK2), mRNA","Q0P5I2",1048,0,"Interleukin-1 receptor-associated kinase-like 2","BH2504_1",80.9,{"v":2e-15,"d":"2.00E-15"},"COG0515","pfam00069","Pkinase","Protein kinase domain.","GO:0007249|I-kappaB kinase/NF-kappaB signaling;GO:0006954|inflammatory response;GO:0070498|interleukin-1-mediated signaling pathway;GO:0035556|intracellular signal transduction;GO:0031663|lipopolysaccharide-mediated signaling pathway;GO:0002755|MyD88-dependent toll-like receptor signaling pathway;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0001959|regulation of cytokine-mediated signaling pathway;GO:0002224|toll-like receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0004674|protein serine/threonine kinase activity;","K04731","IRAK2; interleukin-1 receptor-associated kinase 2 [EC:2.7.11.1]"]
["gene27109",2097,4281,4633,3372.38084083529,1448,1405,1413,1566.88842040231,2.15227887124815,1.1058650203206,{"v":1.81342191764698e-05,"d":"1.81E-05"},0.000702972020820463,"up","yes","BHLHE40","protein_coding","chrNC_037349.1:21400616-21406318:-","gi|67972413|ref|NP_001020100.1|",1787,0,"class E basic helix-loop-helix protein 40 [Bos taurus]","gi|67972412|ref|NM_001024929.1|",2536,0,"Bos taurus basic helix-loop-helix family member e40 (BHLHE40), mRNA","Q5EA15",692,0,"Class E basic helix-loop-helix protein 40",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0032922|circadian regulation of gene expression;GO:0043153|entrainment of circadian clock by photoperiod;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0016604|nuclear body;","GO:0070888|E-box binding;GO:0043426|MRF binding;GO:0019904|protein domain specific binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0001102|RNA polymerase II activating transcription factor binding;GO:0003714|transcription corepressor activity;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001191|transcriptional repressor activity, RNA polymerase II transcription factor binding;","K03729","BHLHB2, DEC1; class B basic helix-loop-helix protein 2"]
["gene2713",4,199,9,69.0224058119295,2,0,2,1.46948195727625,46.9705704586299,5.55368521015303,{"v":2.07981367071048e-13,"d":"2.08E-13"},{"v":5.5980343244378e-11,"d":"5.60E-11"},"up","yes","KIF17","protein_coding","chrNC_037329.1:131918127-131969114:+","gi|157412276|ref|NP_001098682.1|",5020,0,"kinesin-like protein KIF17 [Bos taurus]","gi|157412275|ref|NM_001105212.1|",2008,0,"Bos taurus kinesin family member 17 (KIF17), mRNA","Q99PW8",1446,0,"Kinesin-like protein KIF17","SPAC1834.07",248,{"v":5e-70,"d":"5.00E-70"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0030030|cell projection organization;GO:0042073|intraciliary transport;GO:0007017|microtubule-based process;GO:0022008|neurogenesis;GO:0015031|protein transport;GO:0031503|protein complex localization;GO:0016192|vesicle-mediated transport;","GO:0005930|axoneme;GO:0036064|ciliary basal body;GO:0005929|cilium;GO:0032839|dendrite cytoplasm;GO:0030992|intraciliary transport particle B;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;GO:1990075|periciliary membrane compartment;GO:0032391|photoreceptor connecting cilium;","GO:0005524|ATP binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;",".","."]
["gene27157",4150,5629,4149,4200.5569069642,1418,2114,1860,1977.22444524888,2.12447146152669,1.08710396375454,{"v":3.26957900543491e-05,"d":"3.27E-05"},0.00113948026699255,"up","yes","MITF","protein_coding","chrNC_037349.1:31614654-31843514:-","gi|982961593|ref|XP_015314991.1|",2159,0,"PREDICTED: microphthalmia-associated transcription factor isoform X6 [Bos taurus]","gi|982961598|ref|XM_015459508.1|",4667,0,"PREDICTED: Bos taurus microphthalmia-associated transcription factor (MITF), transcript variant X9, mRNA","O75030",791,0,"Microphthalmia-associated transcription factor",".",".",".",".","pfam11851","DUF3371","Domain of unknown function (DUF3371). This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is typically between 125 to 142 amino acids in length.","GO:0046849|bone remodeling;GO:0043010|camera-type eye development;GO:0044336|canonical Wnt signaling pathway involved in negative regulation of apoptotic process;GO:0045165|cell fate commitment;GO:0030318|melanocyte differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030316|osteoclast differentiation;GO:2000144|positive regulation of DNA-templated transcription, initiation;GO:0010628|positive regulation of gene expression;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0065003|macromolecular complex assembly;GO:0042127|regulation of cell proliferation;GO:0045670|regulation of osteoclast differentiation;GO:2001141|regulation of RNA biosynthetic process;GO:0006355|regulation of transcription, DNA-templated;","GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0003682|chromatin binding;GO:0070888|E-box binding;GO:0046983|protein dimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09455","MITF; microphthalmia-associated transcription factor"]
["gene27185",5315,1550,2695,2720.86770912852,813,503,717,747.285765542976,3.6410003168621,1.86433486633457,{"v":1.88273865814402e-08,"d":"1.88E-08"},{"v":1.88478654931603e-06,"d":"1.88E-06"},"up","yes","ADAMTS9","protein_coding","chrNC_037349.1:36760587-36923586:+","gi|529001239|ref|XP_005222743.1|",9841,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X1 [Bos taurus]","gi|982961702|ref|XM_005222686.3|",7168,0,"PREDICTED: Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9), transcript variant X1, mRNA","Q9P2N4",3403,0,"A disintegrin and metalloproteinase with thrombospondin motifs 9",".",".",".",".","pfam08685","GON","GON domain. The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.","GO:0035909|aorta morphogenesis;GO:0030198|extracellular matrix organization;GO:0006516|glycoprotein catabolic process;GO:0003179|heart valve morphogenesis;GO:0007275|multicellular organismal development;GO:0010596|negative regulation of endothelial cell migration;GO:1903671|negative regulation of sprouting angiogenesis;GO:0045636|positive regulation of melanocyte differentiation;GO:0015031|protein transport;GO:0006508|proteolysis;GO:0003229|ventricular cardiac muscle tissue development;GO:0016192|vesicle-mediated transport;","GO:0009986|cell surface;GO:0005783|endoplasmic reticulum;GO:0031012|extracellular matrix;GO:0005615|extracellular space;GO:0043231|intracellular membrane-bounded organelle;","GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;GO:0008270|zinc ion binding;","K08624","ADAMTS9; a disintegrin and metalloproteinase with thrombospondin motifs 9 [EC:3.4.24.-]"]
["gene2721",1143,1257,1342,1121.99071476855,517,349,492,498.915425321896,2.24885954176432,1.16919355674575,{"v":2.9966874090182e-05,"d":"3.00E-05"},0.00106209302443104,"up","yes","MUL1","protein_coding","chrNC_037329.1:132115914-132123544:+","gi|300794078|ref|NP_001179111.1|",1669,0,"mitochondrial ubiquitin ligase activator of NFKB 1 [Bos taurus]","gi|300794077|ref|NM_001192182.1|",2418,0,"Bos taurus mitochondrial E3 ubiquitin protein ligase 1 (MUL1), mRNA","Q969V5",580,0,"Mitochondrial ubiquitin ligase activator of NFKB 1",".",".",".",".","pfam12483","GIDE","E3 Ubiquitin ligase. This domain family is found in bacteria, archaea and eukaryotes, and is typically between 150 and 163 amino acids in length. There is a single completely conserved residue E that may be functionally important. GIDE is an E3 ubiquitin ligase which is involved in inducing apoptosis.","GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0007257|activation of JUN kinase activity;GO:0006915|apoptotic process;GO:0071360|cellular response to exogenous dsRNA;GO:0000266|mitochondrial fission;GO:0051646|mitochondrion localization;GO:0030308|negative regulation of cell growth;GO:0071650|negative regulation of chemokine (C-C motif) ligand 5 production;GO:0050689|negative regulation of defense response to virus by host;GO:0045824|negative regulation of innate immune response;GO:0010637|negative regulation of mitochondrial fusion;GO:0051898|negative regulation of protein kinase B signaling;GO:0060339|negative regulation of type I interferon-mediated signaling pathway;GO:1903861|positive regulation of dendrite extension;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0090141|positive regulation of mitochondrial fission;GO:0033235|positive regulation of protein sumoylation;GO:0031648|protein destabilization;GO:0050821|protein stabilization;GO:0016567|protein ubiquitination;GO:0051881|regulation of mitochondrial membrane potential;GO:1901028|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:0010821|regulation of mitochondrion organization;","GO:0030424|axon;GO:0031307|integral component of mitochondrial outer membrane;GO:0016020|membrane;GO:0005739|mitochondrion;GO:0043025|neuronal cell body;GO:0005777|peroxisome;","GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0019789|SUMO transferase activity;GO:0031625|ubiquitin protein ligase binding;GO:0004842|ubiquitin-protein transferase activity;","K15688","MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27]"]
["gene27238",1002,680,821,736.139366362618,275,392,288,350.605543719239,2.09962272288572,1.07013011611968,0.000100221983923635,0.00290017370175312,"up","yes","ARHGEF3","protein_coding","chrNC_037349.1:44017433-44330994:+","gi|440912583|gb|ELR62142.1|",2978,0,"Rho guanine nucleotide exchange factor 3, partial [Bos mutus]","gi|983004642|ref|XM_001250879.4|",3643,0,"PREDICTED: Bos taurus Rho guanine nucleotide exchange factor 3 (ARHGEF3), transcript variant X7, mRNA","Q9NR81",1054,0,"Rho guanine nucleotide exchange factor 3","SPAC1006.06",115,{"v":6e-25,"d":"6.00E-25"},"COG5422","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0043065|positive regulation of apoptotic process;GO:0035023|regulation of Rho protein signal transduction;GO:0051056|regulation of small GTPase mediated signal transduction;GO:0007266|Rho protein signal transduction;","GO:0005829|cytosol;GO:0005622|intracellular;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005089|Rho guanyl-nucleotide exchange factor activity;",".","."]
["gene2732",4,6,20,9.15123169474643,0,0,0,0,"Inf","Inf",0.000871533683996852,0.0162308926488996,"up","yes","PLA2G5","protein_coding","chrNC_037329.1:132644532-132665181:-","gi|742228601|ref|XP_010828253.1|",661,{"v":2e-82,"d":"2.00E-82"},"PREDICTED: calcium-dependent phospholipase A2 isoform X1 [Bison bison bison]","gi|300796137|ref|NM_001193052.1|",1182,0,"Bos taurus phospholipase A2 group V (PLA2G5), mRNA","P39877",186,{"v":6e-56,"d":"6.00E-56"},"Calcium-dependent phospholipase A2",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0050482|arachidonic acid secretion;GO:0019370|leukotriene biosynthetic process;GO:0016042|lipid catabolic process;GO:0006654|phosphatidic acid biosynthetic process;GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;GO:0036148|phosphatidylglycerol acyl-chain remodeling;GO:0036149|phosphatidylinositol acyl-chain remodeling;GO:0036150|phosphatidylserine acyl-chain remodeling;GO:0006644|phospholipid metabolic process;GO:0006663|platelet activating factor biosynthetic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0010518|positive regulation of phospholipase activity;GO:0051591|response to cAMP;GO:0034097|response to cytokine;","GO:0005576|extracellular region;GO:0005794|Golgi apparatus;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0047498|calcium-dependent phospholipase A2 activity;GO:0008201|heparin binding;GO:0004623|phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["gene27339",93,155,190,133.387311688329,16,25,12,19.4866533291331,6.84506002315498,2.77506319228352,{"v":1.6937882337963e-09,"d":"1.69E-09"},{"v":2.12887542283887e-07,"d":"2.13E-07"},"up","yes","CACNA2D2","protein_coding","chrNC_037349.1:49846478-49986838:+","gi|803234599|ref|XP_011977410.1|",5466,0,"PREDICTED: voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X3 [Ovis aries musimon]","gi|741969413|ref|XM_010817847.1|",5132,0,"PREDICTED: Bos taurus calcium channel, voltage-dependent, alpha 2/delta subunit 2 (CACNA2D2), transcript variant X3, mRNA","Q9NY47",2079,0,"Voltage-dependent calcium channel subunit alpha-2/delta-2",".",".",".",".","pfam08399","VWA_N","VWA N-terminal. This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.","GO:0048747|muscle fiber development;GO:0007528|neuromuscular junction development;GO:0046622|positive regulation of organ growth;GO:0050796|regulation of insulin secretion;GO:0034765|regulation of ion transmembrane transport;GO:0040014|regulation of multicellular organism growth;GO:0060024|rhythmic synaptic transmission;","GO:0005886|plasma membrane;GO:0005891|voltage-gated calcium channel complex;","GO:0046872|metal ion binding;GO:0005245|voltage-gated calcium channel activity;","K04859","CACNA2D2; voltage-dependent calcium channel alpha-2/delta-2"]
["gene27347",564,662,480,511.358993342276,97,109,126,121.739733712892,4.20042805866696,2.07053635804563,{"v":2.25833861339376e-12,"d":"2.26E-12"},{"v":5.32501313873862e-10,"d":"5.33E-10"},"up","yes","HYAL2","protein_coding","chrNC_037349.1:50018125-50026841:+","gi|27805929|ref|NP_776772.1|",2359,0,"hyaluronidase-2 precursor [Bos taurus]","gi|982961769|ref|XM_010817666.2|",2162,0,"PREDICTED: Bos taurus hyaluronoglucosaminidase 2 (HYAL2), transcript variant X2, mRNA","Q8SQG8",912,0,"Hyaluronidase-2",".",".",".",".","pfam01630","Glyco_hydro_56","Hyaluronidase.","GO:0005975|carbohydrate metabolic process;GO:0051216|cartilage development;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0071347|cellular response to interleukin-1;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0071493|cellular response to UV-B;GO:0051607|defense response to virus;GO:0019064|fusion of virus membrane with host plasma membrane;GO:0006027|glycosaminoglycan catabolic process;GO:0002244|hematopoietic progenitor cell differentiation;GO:0030214|hyaluronan catabolic process;GO:0042117|monocyte activation;GO:0010259|multicellular organismal aging;GO:0060586|multicellular organismal iron ion homeostasis;GO:0030308|negative regulation of cell growth;GO:0010764|negative regulation of fibroblast migration;GO:0043407|negative regulation of MAP kinase activity;GO:0051898|negative regulation of protein kinase B signaling;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:0050729|positive regulation of inflammatory response;GO:2000778|positive regulation of interleukin-6 secretion;GO:2000484|positive regulation of interleukin-8 secretion;GO:0042307|positive regulation of protein import into nucleus;GO:0035810|positive regulation of urine volume;GO:0070295|renal water absorption;GO:0046677|response to antibiotic;GO:0000302|response to reactive oxygen species;GO:0009615|response to virus;GO:0048705|skeletal system morphogenesis;GO:0019087|transformation of host cell by virus;GO:0046718|viral entry into host cell;","GO:0031362|anchored component of external side of plasma membrane;GO:0046658|anchored component of plasma membrane;GO:0016324|apical plasma membrane;GO:0031410|cytoplasmic vesicle;GO:0005829|cytosol;GO:0030139|endocytic vesicle;GO:0005764|lysosome;GO:0045121|membrane raft;GO:0005902|microvillus;GO:0048471|perinuclear region of cytoplasm;GO:0090575|RNA polymerase II transcription factor complex;","GO:0005540|hyaluronic acid binding;GO:0033906|hyaluronoglucuronidase activity;GO:0004415|hyalurononglucosaminidase activity;GO:0030294|receptor signaling protein tyrosine kinase inhibitor activity;GO:0030971|receptor tyrosine kinase binding;GO:0001105|RNA polymerase II transcription coactivator activity;GO:0050431|transforming growth factor beta binding;GO:0001618|virus receptor activity;","K01197","hya; hyaluronoglucosaminidase [EC:3.2.1.35]"]
["gene27348",425,427,378,366.792302180467,91,183,133,149.181015496174,2.45870629691399,1.29789940907287,0.00258255809587901,0.0369894402778736,"up","yes","HYAL1","protein_coding","chrNC_037349.1:50029801-50036547:+","gi|741969419|ref|XP_003587688.2|",2354,0,"PREDICTED: hyaluronidase-1 [Bos taurus]","gi|742171339|ref|XM_010851813.1|",2038,0,"PREDICTED: Bison bison bison hyaluronoglucosaminidase 1 (HYAL1), transcript variant X1, mRNA","Q5E985",910,0,"Hyaluronidase-1",".",".",".",".","pfam01630","Glyco_hydro_56","Hyaluronidase.","GO:0005975|carbohydrate metabolic process;GO:0051216|cartilage development;GO:0071347|cellular response to interleukin-1;GO:0071467|cellular response to pH;GO:0036120|cellular response to platelet-derived growth factor stimulus;GO:0071493|cellular response to UV-B;GO:0030213|hyaluronan biosynthetic process;GO:0030214|hyaluronan catabolic process;GO:0030212|hyaluronan metabolic process;GO:0006954|inflammatory response;GO:0030308|negative regulation of cell growth;GO:0045766|positive regulation of angiogenesis;GO:0045785|positive regulation of cell adhesion;GO:0030307|positive regulation of cell growth;GO:0010634|positive regulation of epithelial cell migration;GO:0050679|positive regulation of epithelial cell proliferation;GO:1900087|positive regulation of G1/S transition of mitotic cell cycle;GO:0045927|positive regulation of growth;GO:1900106|positive regulation of hyaluranon cable assembly;GO:0046677|response to antibiotic;GO:0000302|response to reactive oxygen species;GO:0009615|response to virus;","GO:0005737|cytoplasm;GO:0031410|cytoplasmic vesicle;GO:0005615|extracellular space;GO:0036117|hyaluranon cable;GO:0005764|lysosome;","GO:0050501|hyaluronan synthase activity;GO:0004415|hyalurononglucosaminidase activity;GO:0008134|transcription factor binding;","K01197","hya; hyaluronoglucosaminidase [EC:3.2.1.35]"]
["gene27365",2,95,3,32.5757908991229,0,0,0,0,"Inf","Inf",{"v":1.56388173022915e-09,"d":"1.56E-09"},{"v":1.99192453773071e-07,"d":"1.99E-07"},"up","yes","LOC616410","protein_coding","chrNC_037349.1:50378405-50382767:+","gi|119914715|ref|XP_873518.2|",6083,0,"PREDICTED: uncharacterized protein LOC616410 [Bos taurus]","gi|50872227|gb|AC149756.4|",4363,0,"Bos taurus BAC CH240-361I2 (Children's Hospital Oakland Research Institute Bovine BAC Library (male)) complete sequence","Q9QY83",295,{"v":5e-87,"d":"5.00E-87"},"Actin-like protein 7B","YFL039c",281,{"v":8e-83,"d":"8.00E-83"},"COG5277","pfam00022","Actin","Actin.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;",".",".","."]
["gene27380",14097,27558,28452,21443.474292673,6955,7101,7610,7952.53947575908,2.6964310404289,1.43105113827888,{"v":2.23788040050898e-06,"d":"2.24E-06"},0.000120697477706846,"up","yes","DAG1","protein_coding","chrNC_037349.1:50614127-50665329:-","gi|982961761|ref|XP_010815965.2|",4004,0,"PREDICTED: dystroglycan isoform X1 [Bos taurus]","gi|982961763|ref|XM_005222706.3|",5379,0,"PREDICTED: Bos taurus dystroglycan 1 (DAG1), transcript variant X3, mRNA","O18738",1507,0,"Dystroglycan",".",".",".",".","pfam05454","DAG1","Dystroglycan (Dystrophin-associated glycoprotein 1). Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in human. The protein product is cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and [beta] (C-terminal). In skeletal muscle the dystroglycan complex works as a transmembrane linkage between the extracellular matrix and the cytoskeleton. [alpha]-dystroglycan is extracellular and binds to merosin ([alpha]-2 laminin) in the basement membrane, while [beta]-dystroglycan is a transmembrane protein and binds to dystrophin, which is a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients. Dystrophin binds to intracellular actin cables. In this way, the dystroglycan complex, which links the extracellular matrix to the intracellular actin cables, is thought to provide structural integrity in muscle tissues. The dystroglycan complex is also known to serve as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. There is also evidence which suggests the function of dystroglycan as a part of the signal transduction pathway because it is shown that Grb2, a mediator of the Ras-related signal pathway, can interact with the cytoplasmic domain of dystroglycan. In general, aberrant expression of dystrophin-associated protein complex underlies the pathogenesis of Duchenne muscular dystrophy, Becker muscular dystrophy and severe childhood autosomal recessive muscular dystrophy. Interestingly, no genetic disease has been described for either [alpha]- or [beta]-dystroglycan. Dystroglycan is widely distributed in non-muscle tissues as well as in muscle tissues. During epithelial morphogenesis of kidney, the dystroglycan complex is shown to act as a receptor for the basement membrane. Dystroglycan expression in mouse brain and neural retina has also been reported. However, the physiological role of dystroglycan in non-muscle tissues has remained unclear.","GO:0007016|cytoskeletal anchoring at plasma membrane;","GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0016010|dystrophin-associated glycoprotein complex;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005654|nucleoplasm;GO:0045211|postsynaptic membrane;GO:0042383|sarcolemma;","GO:0005509|calcium ion binding;GO:0043236|laminin binding;","K06265","DAG1; dystroglycan 1"]
["gene27392",197,217,273,206.301720019576,50,57,55,59.4602048065708,3.46957634422372,1.79475951196725,{"v":8.40607310829323e-07,"d":"8.41E-07"},{"v":5.19120501845702e-05,"d":"5.19E-05"},"up","yes","KLHDC8B","protein_coding","chrNC_037349.1:50843123-50863829:-","gi|742171545|ref|XP_010850174.1|",1350,{"v":9e-170,"d":"9.00E-170"},"PREDICTED: kelch domain-containing protein 8B isoform X1 [Bison bison bison]","gi|982962065|ref|XR_001494761.1|",2200,0,"PREDICTED: Bos taurus kelch domain containing 8B (KLHDC8B), transcript variant X3, misc_RNA","Q5E9V5",520,{"v":1e-169,"d":"1.00E-169"},"Kelch domain-containing protein 8B",".",".",".",".","pfam15240","Pro-rich","Proline-rich. This family includes several eukaryotic proline-rich proteins.","GO:0007049|cell cycle;GO:0051301|cell division;GO:0016567|protein ubiquitination;","GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0005737|cytoplasm;GO:0030496|midbody;",".",".","."]
["gene27397",8712,10013,10271,8706.43306000149,4093,3205,4452,4313.07925113173,2.01861189026771,1.01336355662792,0.000152564695660846,0.00412981340787439,"up","yes","LAMB2","protein_coding","chrNC_037349.1:50883580-50897890:+","gi|329663665|ref|NP_001039712.2|",8856,0,"laminin subunit beta-2 precursor [Bos taurus]","gi|329663664|ref|NM_001046247.2|",5580,0,"Bos taurus laminin, beta 2 (laminin S) (LAMB2), mRNA","P55268",3041,0,"Laminin subunit beta-2",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0014002|astrocyte development;GO:0048677|axon extension involved in regeneration;GO:0007411|axon guidance;GO:0007155|cell adhesion;GO:0044267|cellular protein metabolic process;GO:0030198|extracellular matrix organization;GO:0072274|metanephric glomerular basement membrane development;GO:0072249|metanephric glomerular visceral epithelial cell development;GO:0007528|neuromuscular junction development;GO:0043687|post-translational protein modification;GO:0060041|retina development in camera-type eye;GO:0014044|Schwann cell development;GO:0007601|visual perception;","GO:0005605|basal lamina;GO:0005604|basement membrane;GO:0005788|endoplasmic reticulum lumen;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0043260|laminin-11 complex;GO:0005608|laminin-3 complex;GO:0043083|synaptic cleft;","GO:0005178|integrin binding;GO:0005198|structural molecule activity;","K06243","LAMB2; laminin, beta 2"]
["gene2742",278,651,615,474.677273672941,194,159,256,223.271092409219,2.12601312848389,1.08815050577782,0.000851258414794689,0.0159995084535621,"up","yes","LOC535280","protein_coding","chrNC_037329.1:133044262-133055689:-","gi|358411177|ref|XP_615319.4|",663,{"v":3e-79,"d":"3.00E-79"},"PREDICTED: neuroblastoma suppressor of tumorigenicity 1 isoform X2 [Bos taurus]","gi|982978045|ref|XM_010826722.2|",1651,0,"PREDICTED: Bos taurus neuroblastoma suppressor of tumorigenicity 1 (LOC535280), transcript variant X1, mRNA","P41271",249,{"v":3e-77,"d":"3.00E-77"},"Neuroblastoma suppressor of tumorigenicity 1",".",".",".",".","pfam03045","DAN","DAN domain. This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonise different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.","GO:0048263|determination of dorsal identity;GO:0030514|negative regulation of BMP signaling pathway;GO:0090027|negative regulation of monocyte chemotaxis;GO:0007399|nervous system development;GO:0048812|neuron projection morphogenesis;GO:0045666|positive regulation of neuron differentiation;GO:0038098|sequestering of BMP from receptor via BMP binding;GO:0035582|sequestering of BMP in extracellular matrix;","GO:0005615|extracellular space;","GO:0036122|BMP binding;GO:0016015|morphogen activity;GO:0042803|protein homodimerization activity;","K19558","NBL1; neuroblastoma suppressor of tumorigenicity 1"]
["gene27472",69169,3537,14048,23500.6308090042,570,2057,1165,1388.4746558647,16.9255021758886,4.08112673376393,{"v":1.31845556531498e-06,"d":"1.32E-06"},{"v":7.77207763099207e-05,"d":"7.77E-05"},"up","yes","MYL3","protein_coding","chrNC_037349.1:52638286-52644068:+","gi|296474741|tpg|DAA16856.1|",933,{"v":2e-123,"d":"2.00E-123"},"TPA: myosin, light chain 3, alkali; ventricular, skeletal, slow [Bos taurus]","gi|270483785|ref|NM_001076501.2|",924,0,"Bos taurus myosin light chain 3 (MYL3), mRNA","P85100",332,{"v":5e-113,"d":"5.00E-113"},"Myosin light chain 3","SPAC3A12.14",106,{"v":6e-27,"d":"6.00E-27"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0060048|cardiac muscle contraction;GO:0006942|regulation of striated muscle contraction;GO:0002026|regulation of the force of heart contraction;GO:0055010|ventricular cardiac muscle tissue morphogenesis;","GO:0031672|A band;GO:0031674|I band;GO:0016459|myosin complex;","GO:0003785|actin monomer binding;GO:0005509|calcium ion binding;","K12749","MYL3; myosin light chain 3"]
["gene27526",795,4358,2367,2362.34602601749,177,518,304,365.992270789042,6.45463364820386,2.6903352134382,0.00013844962907179,0.00381284398363633,"up","yes","ATP2B2","protein_coding","chrNC_037349.1:54363223-54744502:-","gi|300795567|ref|NP_001178174.1|",5699,0,"plasma membrane calcium-transporting ATPase 2 [Bos taurus]","gi|300795566|ref|NM_001191245.1|",8983,0,"Bos taurus ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2), mRNA","Q9R0K7",2180,0,"Plasma membrane calcium-transporting ATPase 2",".",".",".",".","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0060088|auditory receptor cell stereocilium organization;GO:1901660|calcium ion export;GO:0006816|calcium ion transport;GO:0000902|cell morphogenesis;GO:0006874|cellular calcium ion homeostasis;GO:0021707|cerebellar granule cell differentiation;GO:0021702|cerebellar Purkinje cell differentiation;GO:0021692|cerebellar Purkinje cell layer morphogenesis;GO:0021549|cerebellum development;GO:0046068|cGMP metabolic process;GO:0090102|cochlea development;GO:0050910|detection of mechanical stimulus involved in sensory perception of sound;GO:0048839|inner ear development;GO:0042472|inner ear morphogenesis;GO:0060113|inner ear receptor cell differentiation;GO:0007595|lactation;GO:0040011|locomotion;GO:0007626|locomotory behavior;GO:0050885|neuromuscular process controlling balance;GO:0030182|neuron differentiation;GO:0006996|organelle organization;GO:0045299|otolith mineralization;GO:0051928|positive regulation of calcium ion transport;GO:0008361|regulation of cell size;GO:0051480|cytosolic calcium ion homeostasis;GO:0048167|regulation of synaptic plasticity;GO:0007605|sensory perception of sound;GO:0042428|serotonin metabolic process;GO:0050808|synapse organization;","GO:0016324|apical plasma membrane;GO:0030054|cell junction;GO:0005929|cilium;GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0005783|endoplasmic reticulum;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0043025|neuronal cell body;GO:0032809|neuronal cell body membrane;GO:0005886|plasma membrane;GO:0098839|postsynaptic density membrane;","GO:0033130|acetylcholine receptor binding;GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0030899|calcium-dependent ATPase activity;GO:0005388|calcium-transporting ATPase activity;GO:0005516|calmodulin binding;GO:0035254|glutamate receptor binding;GO:0030165|PDZ domain binding;GO:0008022|protein C-terminus binding;","K05850","ATP2B; Ca2+ transporting ATPase, plasma membrane [EC:3.6.3.8]"]
["gene27539",2,17,14,10.3921498906979,0,0,0,0,"Inf","Inf",0.000407735347806986,0.00898908700547477,"up","yes","TRH","protein_coding","chrNC_037349.1:55886890-55889851:-","gi|116014872|gb|ABJ52714.1|",831,{"v":6e-105,"d":"6.00E-105"},"thyrotropin releasing hormone [Bos taurus]","gi|198282114|ref|NM_001101221.1|",1129,0,"Bos taurus thyrotropin-releasing hormone (TRH), mRNA","P20396",202,{"v":7e-61,"d":"7.00E-61"},"Pro-thyrotropin-releasing hormone",".",".",".",".","pfam05438","TRH","Thyrotropin-releasing hormone (TRH). This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localized on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.","GO:0007628|adult walking behavior;GO:0007267|cell-cell signaling;GO:0042755|eating behavior;GO:0007186|G-protein coupled receptor signaling pathway;GO:0001692|histamine metabolic process;GO:0009755|hormone-mediated signaling pathway;GO:2000252|negative regulation of feeding behavior;GO:0014050|negative regulation of glutamate secretion;GO:0014054|positive regulation of gamma-aminobutyric acid secretion;GO:0032024|positive regulation of insulin secretion;GO:0009409|response to cold;GO:0051412|response to corticosterone;GO:0045471|response to ethanol;GO:0009749|response to glucose;GO:0001666|response to hypoxia;GO:0007165|signal transduction;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0030141|secretory granule;","GO:0008437|thyrotropin-releasing hormone activity;","K05253","TRH; thyrotropin-releasing hormone"]
["gene27574",2764,935,980,1327.75785760939,412,565,455,525.583093881433,2.52625678616085,1.3370012920518,{"v":3.03861478228903e-07,"d":"3.04E-07"},{"v":2.17825925511277e-05,"d":"2.18E-05"},"up","yes","FGD5","protein_coding","chrNC_037349.1:57381762-57505298:-","gi|982962805|ref|XP_010816283.2|",6380,0,"PREDICTED: FYVE, RhoGEF and PH domain-containing protein 5 isoform X1 [Bos taurus]","gi|983004819|ref|XM_010825206.2|",5797,0,"PREDICTED: Bos taurus FYVE, RhoGEF and PH domain containing 5 (FGD5), transcript variant X1, mRNA","Q6ZNL6",1694,0,"FYVE, RhoGEF and PH domain-containing protein 5",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0030036|actin cytoskeleton organization;GO:0007010|cytoskeleton organization;GO:0046847|filopodium assembly;GO:0008360|regulation of cell shape;GO:0043087|regulation of GTPase activity;GO:0035023|regulation of Rho protein signal transduction;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0030027|lamellipodium;GO:0001726|ruffle;GO:0032587|ruffle membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046872|metal ion binding;GO:0005089|Rho guanyl-nucleotide exchange factor activity;GO:0031267|small GTPase binding;","K05724","FGD5_6; FYVE, RhoGEF and PH domain containing 5/6"]
["gene27577",595,923,722,679.296063290279,108,261,166,196.072208729451,3.4645198709808,1.79265543093388,0.000502495092962703,0.0106012525291977,"up","yes","GRIP2","protein_coding","chrNC_037349.1:57664996-57768873:+","gi|296474679|tpg|DAA16794.1|",5017,0,"TPA: KIAA1719 protein-like [Bos taurus]","gi|983004827|ref|XM_586520.9|",5116,0,"PREDICTED: Bos taurus glutamate receptor interacting protein 2 (GRIP2), transcript variant X1, mRNA","Q9C0E4",1747,0,"Glutamate receptor-interacting protein 2",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.",".","GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0030159|receptor signaling complex scaffold activity;",".","."]
["gene2758",310,917,468,525.043239780262,247,178,232,241.39021567694,2.17508086774711,1.12106904019304,0.000178587853611158,0.00462787470606716,"up","yes","IFFO2","protein_coding","chrNC_037329.1:133705662-133755297:+","gi|803288245|ref|XP_012003776.1|",1885,0,"PREDICTED: intermediate filament family orphan 2 isoform X2 [Ovis aries musimon]","gi|982978114|ref|XM_015462507.1|",5236,0,"PREDICTED: Bos taurus intermediate filament family orphan 2 (IFFO2), mRNA","Q5TF58",724,0,"Intermediate filament family orphan 2",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".","GO:0005882|intermediate filament;",".",".","."]
["gene27626",523,226,269,292.985867806608,104,137,129,135.71468094125,2.15883694950761,1.11025428503724,0.000494166306867234,0.0104716060318589,"up","yes","ABTB1","protein_coding","chrNC_037349.1:59833796-59838519:-","gi|529002398|ref|XP_005223223.1|",1916,0,"PREDICTED: ankyrin repeat and BTB/POZ domain-containing protein 1 isoform X2 [Bos taurus]","gi|982962849|ref|XM_005223166.3|",2267,0,"PREDICTED: Bos taurus ankyrin repeat and BTB (POZ) domain containing 1 (ABTB1), transcript variant X2, mRNA","Q99LJ2",551,0,"Ankyrin repeat and BTB/POZ domain-containing protein 1","SPAC13D6.04c",98.2,{"v":6e-32,"d":"6.00E-32"},"COG0666","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162|regulation of proteolysis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005886|plasma membrane;GO:0019005|SCF ubiquitin ligase complex;","GO:0003746|translation elongation factor activity;GO:0031625|ubiquitin protein ligase binding;","K10520","ABTB1, BPOZ; ankyrin repeat and BTB/POZ domain-containing protein 1"]
["gene27639",423,716,487,494.457723060783,59,61,76,71.8724985517106,6.87965122994899,2.78233542807023,{"v":1.26154443946615e-19,"d":"1.26E-19"},{"v":7.86028402831342e-17,"d":"7.86E-17"},"up","yes","SLC41A3","protein_coding","chrNC_037349.1:60518663-60539580:-","gi|594112155|ref|XP_006078876.1|",1856,0,"PREDICTED: solute carrier family 41 member 3 isoform X3 [Bubalus bubalis]","gi|594112154|ref|XM_006078814.1|",3747,0,"PREDICTED: Bubalus bubalis solute carrier family 41, member 3 (SLC41A3), transcript variant X3, mRNA","Q3SWT5",549,{"v":1e-179,"d":"1.00E-179"},"Solute carrier family 41 member 3","PAB0883",56.6,{"v":3e-07,"d":"3.00E-07"},"COG1824","pfam01769","MgtE","Divalent cation transporter. This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)","GO:0055085|transmembrane transport;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0008324|cation transmembrane transporter activity;","K15122","SLC41A; solute carrier family 41"]
["gene27674",307,203,520,306.241272063868,4,12,6,8.06476051933232,37.9727669941055,5.24689322376875,{"v":2.99749627529748e-15,"d":"3.00E-15"},{"v":1.08255147127231e-12,"d":"1.08E-12"},"up","yes","COL21A1","protein_coding","chrNC_037350.1:4026182-4261772:+","gi|555981591|ref|XP_005902709.1|",3787,0,"PREDICTED: collagen alpha-1(XXI) chain [Bos mutus]","gi|983004899|ref|XM_010825259.2|",4132,0,"PREDICTED: Bos taurus collagen type XXI alpha 1 (COL21A1), transcript variant X2, mRNA","Q96P44",1330,0,"Collagen alpha-1(XXI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.",".","GO:0005581|collagen trimer;GO:0005829|cytosol;GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;",".","K16629","COL21A; collagen, type XXI, alpha"]
["gene27721",2952,3852,4178,3314.88248065894,1223,1553,1621,1612.18712111942,2.05614003314779,1.03993852243465,{"v":3.50253631985031e-05,"d":"3.50E-05"},0.0011964449975606,"up","yes","TAPBP","protein_coding","chrNC_037350.1:7473583-7483259:-","gi|114052697|ref|NP_001039350.1|",1745,0,"tapasin precursor [Bos taurus]","gi|114052696|ref|NM_001045885.1|",2345,0,"Bos taurus TAP binding protein (tapasin) (TAPBP), mRNA","O15533",558,0,"Tapasin",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0019885|antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0002479|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0002474|antigen processing and presentation of peptide antigen via MHC class I;GO:0006955|immune response;GO:0050823|peptide antigen stabilization;GO:0065003|macromolecular complex assembly;GO:0010468|regulation of gene expression;GO:0061635|regulation of protein complex stability;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;GO:1990668|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0000139|Golgi membrane;GO:0071556|integral component of lumenal side of endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0042824|MHC class I peptide loading complex;GO:0030670|phagocytic vesicle membrane;","GO:0042288|MHC class I protein binding;GO:0042605|peptide antigen binding;GO:0015433|peptide antigen-transporting ATPase activity;GO:0046978|TAP1 binding;GO:0046979|TAP2 binding;GO:0051082|unfolded protein binding;","K08058","TAPBP; TAP binding protein (tapasin)"]
["gene27736",1432,1878,2288,1691.36057439477,558,775,747,762.624707964556,2.21781507566022,1.14913907670329,{"v":4.77434413746169e-06,"d":"4.77E-06"},0.000227028020976533,"up","yes","MNF1","protein_coding","chrNC_037350.1:7814519-7840352:-","gi|965991489|ref|XP_014958058.1|",739,{"v":3e-97,"d":"3.00E-97"},"PREDICTED: ubiquinol-cytochrome-c reductase complex assembly factor 2 isoform X1 [Ovis aries]","gi|331028751|ref|NM_001206614.1|",512,0,"Bos taurus mitochondrial nucleoid factor 1 (MNF1), mRNA","Q3SZ13",283,{"v":1e-96,"d":"1.00E-96"},"Ubiquinol-cytochrome-c reductase complex assembly factor 2",".",".",".",".","pfam09924","DUF2156","Uncharacterized conserved protein (DUF2156). This domain, found in various hypothetical prokaryotic proteins, has no known function.","GO:0034551|mitochondrial respiratory chain complex III assembly;GO:1903364|positive regulation of cellular protein catabolic process;GO:0070131|positive regulation of mitochondrial translation;GO:0050796|regulation of insulin secretion;GO:0002082|regulation of oxidative phosphorylation;GO:2001014|regulation of skeletal muscle cell differentiation;","GO:0005743|mitochondrial inner membrane;GO:0005758|mitochondrial intermembrane space;GO:0005759|mitochondrial matrix;GO:0042645|mitochondrial nucleoid;GO:0005739|mitochondrion;",".","K17682","MNF1; mitochondrial nucleoid factor 1"]
["gene27737",5527,8741,7933,6741.44078335163,2135,1822,2139,2238.76723164498,3.01122898712351,1.59035242112344,{"v":4.64796649165713e-10,"d":"4.65E-10"},{"v":6.80057087043434e-08,"d":"6.80E-08"},"up","yes","IP6K3","protein_coding","chrNC_037350.1:7852686-7877221:-","gi|742159764|ref|XP_010846922.1|",1979,0,"PREDICTED: inositol hexakisphosphate kinase 3 [Bison bison bison]","gi|331028742|ref|NM_001040542.2|",2480,0,"Bos taurus inositol hexakisphosphate kinase 3 (IP6K3), mRNA","Q96PC2",607,0,"Inositol hexakisphosphate kinase 3",".",".",".",".","pfam03770","IPK","Inositol polyphosphate kinase. ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.","GO:0032958|inositol phosphate biosynthetic process;GO:0043647|inositol phosphate metabolic process;GO:0046488|phosphatidylinositol metabolic process;GO:0006468|protein phosphorylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0052836|inositol 5-diphosphate pentakisphosphate 5-kinase activity;GO:0052839|inositol diphosphate tetrakisphosphate kinase activity;GO:0000829|inositol heptakisphosphate kinase activity;GO:0052723|inositol hexakisphosphate 1-kinase activity;GO:0052724|inositol hexakisphosphate 3-kinase activity;GO:0000832|inositol hexakisphosphate 5-kinase activity;GO:0000831|inositol hexakisphosphate 6-kinase activity;GO:0000828|inositol hexakisphosphate kinase activity;GO:0000827|inositol-1,3,4,5,6-pentakisphosphate kinase activity;","K07756","IP6K, IHPK; inositol-hexakisphosphate 5-kinase [EC:2.7.4.21]"]
["gene27771",13021,13262,11680,11326.9477090248,2957,5173,3659,4324.45873590951,2.61927524362018,1.38916767165533,0.000173194327291173,0.00453756414319968,"up","yes","FKBP5","protein_coding","chrNC_037350.1:9555619-9677847:-","gi|927156378|ref|XP_013833279.1|",2269,0,"PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP5 isoform X1 [Sus scrofa]","gi|982963274|ref|XM_005223349.3|",2313,0,"PREDICTED: Bos taurus FK506 binding protein 5 (FKBP5), transcript variant X2, mRNA","Q13451",849,0,"Peptidyl-prolyl cis-trans isomerase FKBP5","slr1761",112,{"v":2e-26,"d":"2.00E-26"},"COG0545","pfam00254","FKBP_C","FKBP-type peptidyl-prolyl cis-trans isomerase.","GO:0061077|chaperone-mediated protein folding;GO:0006457|protein folding;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016020|membrane;GO:0005654|nucleoplasm;","GO:0005528|FK506 binding;GO:0031072|heat shock protein binding;GO:0003755|peptidyl-prolyl cis-trans isomerase activity;","K09571","FKBP4_5; FK506-binding protein 4/5 [EC:5.2.1.8]"]
["gene27773",787,735,489,596.165460441305,180,234,232,236.899057497961,2.51653791592833,1.33144033465567,{"v":1.98819471752678e-06,"d":"1.99E-06"},0.000109719890688117,"up","yes","ARMC12","protein_coding","chrNC_037350.1:9705287-9728635:+","gi|982963302|ref|XP_015315262.1|",1723,0,"PREDICTED: armadillo repeat-containing protein 12 isoform X1 [Bos taurus]","gi|983005006|ref|XR_001499232.1|",1847,0,"PREDICTED: Bos taurus uncharacterized LOC107131714 (LOC107131714), transcript variant X2, ncRNA","Q5T9G4",547,0,"Armadillo repeat-containing protein 12",".",".",".",".","pfam04826","Arm_2","Armadillo-like. This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.",".","GO:0005634|nucleus;",".",".","."]
["gene27814",564,361,417,393.367308983781,183,143,173,183.327092571735,2.14571290836273,1.10145705960389,0.000236050183692893,0.00574637183527469,"up","yes","PIM1","protein_coding","chrNC_037350.1:11066555-11071948:+","gi|223712706|gb|ACN22070.1|",1667,0,"Pim-1 oncogene 44 kDa isoform [Ovis aries]","gi|31342749|ref|NM_174144.2|",2704,0,"Bos taurus Pim-1 proto-oncogene, serine/threonine kinase (PIM1), mRNA","P11309",637,0,"Serine/threonine-protein kinase pim-1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006915|apoptotic process;GO:0007049|cell cycle;GO:0008283|cell proliferation;GO:0019221|cytokine-mediated signaling pathway;GO:0030212|hyaluronan metabolic process;GO:0007275|multicellular organismal development;GO:0043066|negative regulation of apoptotic process;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0031659|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0007346|regulation of mitotic cell cycle;GO:0070561|vitamin D receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0030145|manganese ion binding;GO:0004674|protein serine/threonine kinase activity;GO:0043024|ribosomal small subunit binding;GO:0008134|transcription factor binding;","K04702","PIM1; proto-oncogene serine/threonine-protein kinase Pim-1 [EC:2.7.11.1]"]
["gene27831",2,58,9,22.2929665701277,2,0,3,1.83045484572949,12.1789218795196,3.60631452140639,0.000214949582498692,0.00533240697670016,"up","yes","DNAH8","protein_coding","chrNC_037350.1:12560530-12888873:+","gi|982963353|ref|XP_015315271.1|",24520,0,"PREDICTED: dynein heavy chain 8, axonemal [Bos taurus]","gi|983005046|ref|XM_015468876.1|",14378,0,"PREDICTED: Bos taurus dynein, axonemal, heavy chain 8 (DNAH8), mRNA","Q91XQ0",8780,0,"Dynein heavy chain 8, axonemal","YKR054c",654,0,"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.","GO:0003341|cilium movement;GO:0036158|outer dynein arm assembly;","GO:0030286|dynein complex;GO:0005874|microtubule;GO:0036157|outer dynein arm;GO:0097228|sperm principal piece;","GO:0005524|ATP binding;GO:0008569|ATP-dependent microtubule motor activity, minus-end-directed;GO:0045505|dynein intermediate chain binding;GO:0045503|dynein light chain binding;GO:0051959|dynein light intermediate chain binding;","K10408","DNAH; dynein heavy chain, axonemal"]
["gene27874",843,2215,1756,1484.90563671135,516,796,639,715.648115172619,2.07491028793275,1.05304896057884,0.000544089722322909,0.0112494288271336,"up","yes","TFEB","protein_coding","chrNC_037350.1:15499140-15547531:-","gi|440905525|gb|ELR55897.1|",1724,0,"Transcription factor EB, partial [Bos mutus]","gi|329664013|ref|NM_001205666.1|",2070,0,"Bos taurus transcription factor EB (TFEB), mRNA","Q9R210",614,0,"Transcription factor EB",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0002250|adaptive immune response;GO:0006914|autophagy;GO:0050829|defense response to Gram-negative bacterium;GO:0001892|embryonic placenta development;GO:0006959|humoral immune response;GO:0007040|lysosome organization;GO:0010508|positive regulation of autophagy;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:1902477|regulation of defense response to bacterium, incompatible interaction;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0044212|transcription regulatory region DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K15590","TFEB; transcription factor EB"]
["gene27886",653,183,245,305.404109182837,61,99,108,98.116694784183,3.11266201796342,1.63814893322215,{"v":5.71857063106019e-06,"d":"5.72E-06"},0.000264435232860257,"up","yes","C23H6orf132","protein_coding","chrNC_037350.1:15831094-15868534:-","gi|982963570|ref|XP_015315308.1|",2175,0,"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein C6orf132 homolog [Bos taurus]","gi|983005071|ref|XM_015468882.1|",4578,0,"PREDICTED: Bos taurus chromosome 23 open reading frame, human C6orf132 (C23H6orf132), mRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["gene27916",7239,16494,17322,12611.9879496504,2914,4133,3543,3884.84678122196,3.24645698013432,1.69886609186683,{"v":1.08765827133689e-09,"d":"1.09E-09"},{"v":1.43666565460707e-07,"d":"1.44E-07"},"up","yes","KLHDC3","protein_coding","chrNC_037350.1:16655058-16661311:+","gi|62460626|ref|NP_001014966.1|",1987,0,"kelch domain-containing protein 3 [Bos taurus]","gi|62460625|ref|NM_001014966.1|",1787,0,"Bos taurus kelch domain containing 3 (KLHDC3), mRNA","Q58CV6",769,0,"Kelch domain-containing protein 3",".",".",".",".","pfam13854","Kelch_5","Kelch motif. The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that the Drosophila ring canal kelch protein is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.","GO:0051321|meiotic cell cycle;","GO:0005737|cytoplasm;",".",".","."]
["gene27947",5017,1166,1831,2252.00530429859,881,977,1039,1062.88737345849,2.1187619314461,1.08322149256268,{"v":3.14582736684144e-05,"d":"3.15E-05"},0.00110186412031176,"up","yes","MRPS18A","protein_coding","chrNC_037350.1:17176264-17195058:-","gi|529003185|ref|XP_005223557.1|",974,{"v":9e-119,"d":"9.00E-119"},"PREDICTED: 28S ribosomal protein S18a, mitochondrial isoform X1 [Bos taurus]","gi|850492819|gb|CP011905.1|",2005,0,"Ovis canadensis canadensis isolate 43U chromosome 20 sequence","P82919",327,{"v":3e-101,"d":"3.00E-101"},"28S ribosomal protein S18a, mitochondrial",".",".",".",".","pfam01084","Ribosomal_S18","Ribosomal protein S18.","GO:0032543|mitochondrial translation;","GO:0022627|cytosolic small ribosomal subunit;GO:0005743|mitochondrial inner membrane;GO:0005763|mitochondrial small ribosomal subunit;","GO:0003735|structural constituent of ribosome;","K02963","RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18"]
["gene27949",13306,1956,3170,5082.44414840841,2048,1556,2131,2105.74293134008,2.41361092693968,1.27119313300511,{"v":1.75839699067614e-06,"d":"1.76E-06"},{"v":9.93442070118434e-05,"d":"9.93E-05"},"up","yes","VEGFA","protein_coding","chrNC_037350.1:17281915-17297193:+","gi|194271211|gb|ACF37105.1|",1375,{"v":1e-178,"d":"1.00E-178"},"vascular endothelial growth factor [Sus scrofa]","gi|947213566|ref|NM_001316956.1|",2808,0,"Bos taurus vascular endothelial growth factor A (VEGFA), transcript variant 4, mRNA","P15691",360,{"v":2e-116,"d":"2.00E-116"},"Vascular endothelial growth factor A",".",".",".",".","pfam00341","PDGF","PDGF/VEGF domain.","GO:0001525|angiogenesis;GO:0071456|cellular response to hypoxia;GO:0050930|induction of positive chemotaxis;GO:0097475|motor neuron migration;GO:0045766|positive regulation of angiogenesis;GO:0051781|positive regulation of cell division;GO:0010595|positive regulation of endothelial cell migration;GO:0001938|positive regulation of endothelial cell proliferation;GO:0051894|positive regulation of focal adhesion assembly;GO:0060754|positive regulation of mast cell chemotaxis;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0031334|positive regulation of protein complex assembly;GO:0001934|positive regulation of protein phosphorylation;GO:0035148|tube formation;GO:0048010|vascular endothelial growth factor receptor signaling pathway;","GO:0005615|extracellular space;GO:0016020|membrane;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0042803|protein homodimerization activity;GO:0043183|vascular endothelial growth factor receptor 1 binding;GO:0043184|vascular endothelial growth factor receptor 2 binding;","K05448","VEGFA; vascular endothelial growth factor A"]
["gene27979",862,1218,1225,1000.04136459637,271,357,332,352.148713535811,2.83982682928266,1.50580295784534,{"v":8.26986370359457e-09,"d":"8.27E-09"},{"v":8.80401049728569e-07,"d":"8.80E-07"},"up","yes","ENPP4","protein_coding","chrNC_037350.1:19386682-19401598:+","gi|440905365|gb|ELR55750.1|",2287,0,"Ectonucleotide pyrophosphatase/phosphodiesterase family member 4, partial [Bos mutus]","gi|982963511|ref|XM_005223466.3|",4664,0,"PREDICTED: Bos taurus ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) (ENPP4), transcript variant X1, mRNA","A2VDP5",882,0,"Bis(5'-adenosyl)-triphosphatase ENPP4","CC1277",231,{"v":3e-64,"d":"3.00E-64"},"COG1524","pfam01663","Phosphodiest","Type I phosphodiesterase / nucleotide pyrophosphatase. This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.","GO:0007596|blood coagulation;GO:0030194|positive regulation of blood coagulation;GO:0046130|purine ribonucleoside catabolic process;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0047710|bis(5'-adenosyl)-triphosphatase activity;GO:0046872|metal ion binding;","K18424","ENPP4; ectonucleotide pyrophosphatase/phosphodiesterase family member 4 [EC:3.6.1.29]"]
["gene27985",29,28,16,21.6481150237643,1,2,0,1.10774322816377,19.5425388062618,4.28854599746889,{"v":3.36748625594736e-05,"d":"3.37E-05"},0.00116610978989336,"up","yes","TDRD6","protein_coding","chrNC_037350.1:19910664-19922053:+","gi|300797062|ref|NP_001179259.1|",10658,0,"tudor domain-containing protein 6 [Bos taurus]","gi|300797061|ref|NM_001192330.1|",6808,0,"Bos taurus tudor domain containing 6 (TDRD6), mRNA","O60522",3105,0,"Tudor domain-containing protein 6",".",".",".",".","pfam00567","TUDOR","Tudor domain.","GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0007283|spermatogenesis;","GO:0033391|chromatoid body;GO:0005737|cytoplasm;",".","K18405","TDRD1_4_6_7; tudor domain-containing protein 1/4/6/7"]
["gene27989",12015,4092,4162,5750.64917297737,1895,2471,2126,2382.54517472486,2.41365797970293,1.27122125772304,{"v":1.34005354294418e-06,"d":"1.34E-06"},{"v":7.8734046168592e-05,"d":"7.87E-05"},"up","yes","ADGRF5","protein_coding","chrNC_037350.1:20061552-20174710:-","gi|741970545|ref|XP_010816508.1|",6881,0,"PREDICTED: adhesion G protein-coupled receptor F5 isoform X3 [Bos taurus]","gi|741970544|ref|XM_010818206.1|",5843,0,"PREDICTED: Bos taurus adhesion G protein-coupled receptor F5 (ADGRF5), transcript variant X4, mRNA","Q8IZF2",1850,0,"Adhesion G protein-coupled receptor F5",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;GO:0006112|energy reserve metabolic process;GO:0048821|erythrocyte development;GO:0045444|fat cell differentiation;GO:0007186|G-protein coupled receptor signaling pathway;GO:0003094|glomerular filtration;GO:0042593|glucose homeostasis;GO:0043031|negative regulation of macrophage activation;GO:0061626|pharyngeal arch artery morphogenesis;GO:0071073|positive regulation of phospholipid biosynthetic process;GO:0043129|surfactant homeostasis;","GO:0045177|apical part of cell;GO:0009986|cell surface;GO:0031410|cytoplasmic vesicle;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;","K08458","GPR116; G protein-coupled receptor 116"]
["gene28024",0,70,1,23.2473591780695,0,0,0,0,"Inf","Inf",{"v":2.4269963361526e-07,"d":"2.43E-07"},{"v":1.78926698880542e-05,"d":"1.79E-05"},"up","yes","PGK2","protein_coding","chrNC_037350.1:22503346-22504971:-","gi|555986632|ref|XP_005905175.1|",2189,0,"PREDICTED: phosphoglycerate kinase 2 [Bos mutus]","gi|942082768|ref|XM_005905113.2|",1623,0,"PREDICTED: Bos mutus phosphoglycerate kinase 2 (PGK2), mRNA","Q8MIF7",804,0,"Phosphoglycerate kinase 2","SPBC14F5.04c",561,0,"COG0126","pfam00162","PGK","Phosphoglycerate kinase.","GO:0006096|glycolytic process;GO:0016310|phosphorylation;","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0004618|phosphoglycerate kinase activity;","K00927","PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]"]
["gene2803",27,62,32,37.1832157808457,2,10,9,7.66616786634338,4.8503002320221,2.27807405242211,0.00286969523334422,0.0399391583914849,"up","yes","LOC101905319","pseudogene","chrNC_037329.1:136181416-136199136:-","gi|829973372|ref|XP_012605250.1|",310,{"v":4e-44,"d":"4.00E-44"},"PREDICTED: 40S ribosomal protein SA-like [Microcebus murinus]","gi|982978093|ref|XR_001495989.1|",1463,0,"PREDICTED: Bos taurus uncharacterized LOC101905319 (LOC101905319), ncRNA","Q4QY71",117,{"v":6e-37,"d":"6.00E-37"},"40S ribosomal protein SA","SPAPJ698.02c",79.3,{"v":5e-27,"d":"5.00E-27"},"COG0052","pfam00318","Ribosomal_S2","Ribosomal protein S2.","GO:0006412|translation;","GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0015935|small ribosomal subunit;","GO:0005055|laminin receptor activity;GO:0003735|structural constituent of ribosome;",".","."]
["gene28065",897,391,324,461.424065300884,132,24,108,97.1301615131015,4.75057446742374,2.24810198316796,0.00168461014062983,0.027237188956903,"up","yes","BLA-DQB","protein_coding","chrNC_037350.1:25672687-25680507:+","gi|296474336|tpg|DAA16451.1|",1293,{"v":4e-176,"d":"4.00E-176"},"TPA: BOLA class II histocompatibility antigen, DQB*0101 beta chain precursor [Bos taurus]","gi|402746714|ref|NM_001034668.3|",1146,0,"Bos taurus MHC class II antigen (BLA-DQB), mRNA","Q9TVC8",455,{"v":4e-159,"d":"4.00E-159"},"BoLa class II histocompatibility antigen, DQB*0101 beta chain",".",".",".",".","pfam00969","MHC_II_beta","Class II histocompatibility antigen, beta domain.","GO:0002504|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;GO:0006955|immune response;","GO:0016021|integral component of membrane;GO:0042613|MHC class II protein complex;",".",".","."]
["gene28091",2666,976,1252,1399.19028958832,254,336,381,355.775588588099,3.93278891095656,1.97555275295031,{"v":1.2408573573981e-14,"d":"1.24E-14"},{"v":4.02305696180968e-12,"d":"4.02E-12"},"up","yes","NOTCH4","protein_coding","chrNC_037350.1:27171384-27196528:+","gi|594070726|ref|XP_006059241.1|",9169,0,"PREDICTED: neurogenic locus notch homolog protein 4 isoform X2 [Bubalus bubalis]","gi|982963934|ref|XM_010818347.2|",6168,0,"PREDICTED: Bos taurus notch 4 (NOTCH4), transcript variant X3, mRNA","Q99466",2801,0,"Neurogenic locus notch homolog protein 4","all2748",63.5,{"v":4e-09,"d":"4.00E-09"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0001569|patterning of blood vessels;GO:0030154|cell differentiation;GO:0001709|cell fate determination;GO:0001886|endothelial cell morphogenesis;GO:0030097|hemopoiesis;GO:0030879|mammary gland development;GO:0001763|morphogenesis of a branching structure;GO:0045596|negative regulation of cell differentiation;GO:0045602|negative regulation of endothelial cell differentiation;GO:0007219|Notch signaling pathway;GO:0007221|positive regulation of transcription of Notch receptor target;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006367|transcription initiation from RNA polymerase II promoter;GO:0001944|vasculature development;GO:0042060|wound healing;","GO:0009986|cell surface;GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;GO:0005576|extracellular region;GO:0000139|Golgi membrane;GO:0005887|integral component of plasma membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0046982|protein heterodimerization activity;GO:0038023|signaling receptor activity;",".","."]
["gene28094",2338,2700,2964,2404.48338359527,897,1109,1043,1118.75391356187,2.1492513719482,1.10383422723042,{"v":9.26550681541946e-06,"d":"9.27E-06"},0.000404211276683078,"up","yes","RNF5","protein_coding","chrNC_037350.1:27209390-27211704:-","gi|817330286|ref|XP_012292172.1|",740,{"v":2e-94,"d":"2.00E-94"},"PREDICTED: E3 ubiquitin-protein ligase RNF5 isoform X1 [Aotus nancymaae]","gi|402743821|ref|NM_001105445.2|",1043,0,"Bos taurus ring finger protein 5, E3 ubiquitin protein ligase (RNF5), mRNA","Q99942",286,{"v":2e-94,"d":"2.00E-94"},"E3 ubiquitin-protein ligase RNF5","ECU11g1130",50.4,{"v":1e-06,"d":"1.00E-06"},"COG5574","pfam13923","zf-C3HC4_2","Zinc finger, C3HC4 type (RING finger).","GO:0044257|cellular protein catabolic process;GO:1904380|endoplasmic reticulum mannose trimming;GO:0071712|ER-associated misfolded protein catabolic process;GO:0036503|ERAD pathway;GO:0010507|negative regulation of autophagy;GO:0031648|protein destabilization;GO:0070936|protein K48-linked ubiquitination;GO:0070534|protein K63-linked ubiquitination;GO:2000785|regulation of autophagosome assembly;GO:0009617|response to bacterium;GO:0055085|transmembrane transport;GO:0030433|ER-associated ubiquitin-dependent protein catabolic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0044322|endoplasmic reticulum quality control compartment;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0042802|identical protein binding;GO:0061630|ubiquitin protein ligase activity;GO:0044390|ubiquitin-like protein conjugating enzyme binding;GO:0004842|ubiquitin-protein transferase activity;GO:0008270|zinc ion binding;","K10666","RNF5; E3 ubiquitin-protein ligase RNF5 [EC:2.3.2.27]"]
["gene28211",1103,262,158,421.854680292548,7,53,15,27.4813111145334,15.3506023979129,3.94022336673226,0.00257257452933072,0.0368991070060504,"up","yes","LOC101905956","pseudogene","chrNC_037350.1:28524363-28527998:-","gi|296474302|tpg|DAA16417.1|",1243,{"v":8e-166,"d":"8.00E-166"},"TPA: MHC class I antigen clone 2 [Bos taurus]","gi|406716697|gb|JQ031569.1|",871,0,"Bos taurus MHC class I antigen (BoLA) mRNA, BoLA-1.4 allele, complete cds","P13753",380,{"v":2e-127,"d":"2.00E-127"},"BOLA class I histocompatibility antigen, alpha chain BL3-7",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0002474|antigen processing and presentation of peptide antigen via MHC class I;GO:0006955|immune response;","GO:0016021|integral component of membrane;GO:0042612|MHC class I protein complex;",".",".","."]
["gene28218",2316,1792,2433,1938.10043221939,587,349,684,594.38598621786,3.26067652528574,1.70517132593349,{"v":1.25405323851476e-05,"d":"1.25E-05"},0.000519294527548107,"up","yes","BOLA","protein_coding","chrNC_037350.1:28720499-28724353:-","gi|84370061|ref|NP_001033607.1|",1615,0,"MHC class I heavy chain isoform 1 precursor [Bos taurus]","gi|982963894|ref|XM_010818341.2|",1405,0,"PREDICTED: Bos taurus MHC class I heavy chain (BOLA), transcript variant X1, mRNA","P13753",549,0,"BOLA class I histocompatibility antigen, alpha chain BL3-7",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0002474|antigen processing and presentation of peptide antigen via MHC class I;GO:0006955|immune response;","GO:0016021|integral component of membrane;GO:0042612|MHC class I protein complex;",".",".","."]
["gene28428",77,27,22,35.6730425143445,5,0,4,3.31273200473739,10.7684661672994,3.42874086562187,0.000739166016712743,0.0143561236370533,"up","yes","HIST1H2AJ","protein_coding","chrNC_037350.1:31001741-31002229:-","gi|667257043|ref|XP_008566075.1|",541,{"v":1e-67,"d":"1.00E-67"},"PREDICTED: histone H2A type 1 isoform X1 [Galeopterus variegatus]","gi|983005547|ref|XM_010825385.2|",489,0,"PREDICTED: Bos taurus histone cluster 1, H2aj (HIST1H2AJ), mRNA","Q99878",211,{"v":9e-69,"d":"9.00E-69"},"Histone H2A type 1-J","SPAC19G12.06c",179,{"v":7e-57,"d":"7.00E-57"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006342|chromatin silencing;","GO:0070062|extracellular exosome;GO:0000790|nuclear chromatin;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;","K11251","H2A; histone H2A"]
["gene2845",1252,1122,803,940.618200376038,378,424,408,444.164005830333,2.11772720893404,1.0825167632375,{"v":3.30118158818822e-05,"d":"3.30E-05"},0.00114860990112924,"up","yes","POGK","protein_coding","chrNC_037330.1:2051950-2069656:-","gi|149642907|ref|NP_001092570.1|",3233,0,"pogo transposable element with KRAB domain [Bos taurus]","gi|982915922|ref|XM_005203436.3|",3697,0,"PREDICTED: Bos taurus pogo transposable element with KRAB domain (POGK), transcript variant X5, mRNA","Q9P215",1197,0,"Pogo transposable element with KRAB domain",".",".",".",".","pfam03184","DDE_1","DDE superfamily endonuclease. This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere.","GO:0007275|multicellular organismal development;GO:0006355|regulation of transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;",".","."]
["gene285",3319,2018,1465,1976.27599293416,718,552,651,705.93597721798,2.79951165079085,1.48517518415992,{"v":1.32920691104035e-09,"d":"1.33E-09"},{"v":1.72380010813146e-07,"d":"1.72E-07"},"up","yes","ABI3BP","protein_coding","chrNC_037328.1:45188665-45477101:-","gi|741913314|ref|XP_010799334.1|",7003,0,"PREDICTED: target of Nesh-SH3 isoform X3 [Bos taurus]","gi|982975336|ref|XM_010824537.2|",3478,0,"PREDICTED: Bos taurus ABI family member 3 binding protein (ABI3BP), transcript variant X3, mRNA","Q7Z7G0",900,0,"Target of Nesh-SH3",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0030198|extracellular matrix organization;GO:0010811|positive regulation of cell-substrate adhesion;","GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005614|interstitial matrix;","GO:0005518|collagen binding;GO:0008201|heparin binding;",".","."]
["gene28578",133,396,251,241.52662150066,63,58,37,58.1886655558054,4.15075030839168,2.05337214811117,{"v":1.91759145122056e-08,"d":"1.92E-08"},{"v":1.8941154195917e-06,"d":"1.89E-06"},"up","yes","HIST1H2AM","protein_coding","chrNC_037350.1:31701400-31701912:+","gi|667257043|ref|XP_008566075.1|",553,{"v":3e-69,"d":"3.00E-69"},"PREDICTED: histone H2A type 1 isoform X1 [Galeopterus variegatus]","gi|983005664|ref|XM_871147.5|",513,0,"PREDICTED: Bos taurus histone cluster 1, H2am (HIST1H2AM), mRNA","P02262",216,{"v":1e-70,"d":"1.00E-70"},"Histone H2A type 1","SPAC19G12.06c",181,{"v":2e-57,"d":"2.00E-57"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.",".","GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;",".","."]
["gene28587",94,146,90,99.9863124514954,24,35,27,31.5612670673053,3.16800691931257,1.66357548644247,0.000258317211351343,0.00617774380307223,"up","yes","LOC505183","protein_coding","chrNC_037350.1:31765587-31766074:-","gi|731293538|ref|XP_010614644.1|",482,{"v":6e-59,"d":"6.00E-59"},"PREDICTED: histone H2B type 2-F isoform X2 [Fukomys damarensis]","gi|742138195|ref|XM_010843426.1|",479,0,"PREDICTED: Bison bison bison histone H2B type 1-like (LOC104991078), mRNA","P10854",188,{"v":5e-60,"d":"5.00E-60"},"Histone H2B type 1-M",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006334|nucleosome assembly;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;","K11252","H2B; histone H2B"]
["gene28590",74,228,141,137.309900723725,46,49,67,59.3609065553546,2.31313685540975,1.20985062472037,0.00321343031310362,0.0434307817447463,"up","yes","LOC617875","protein_coding","chrNC_037350.1:31774497-31775289:+","gi|953881761|ref|XP_014590042.1|",430,{"v":8e-49,"d":"8.00E-49"},"PREDICTED: histone H4 [Equus caballus]","gi|402746020|ref|NM_001099724.2|",787,0,"Bos taurus histone H4-like (LOC617875), mRNA","Q28DR4",164,{"v":4e-49,"d":"4.00E-49"},"Histone H4",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006352|DNA-templated transcription, initiation;GO:0006334|nucleosome assembly;","GO:0000788|nuclear nucleosome;","GO:0003677|DNA binding;GO:0042393|histone binding;GO:0046982|protein heterodimerization activity;","K11254","H4; histone H4"]
["gene28597",1774,2616,2292,2023.57785518165,771,1001,880,973.185895929832,2.07933331508901,1.05612103933253,{"v":2.48810053518336e-05,"d":"2.49E-05"},0.000905459137363729,"up","yes","LOC787269","protein_coding","chrNC_037350.1:31829219-31843431:+","gi|578800966|ref|XP_006711398.1|",484,{"v":2e-53,"d":"2.00E-53"},"PREDICTED: histone H2B type 2-F isoform X1 [Homo sapiens]","gi|742138232|ref|XM_010843437.1|",2004,0,"PREDICTED: Bison bison bison histone H1t (LOC104991089), mRNA","P10854",187,{"v":4e-54,"d":"4.00E-54"},"Histone H2B type 1-M",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006334|nucleosome assembly;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;","K11252","H2B; histone H2B"]
["gene28598",4,29,22,17.3029815837142,1,0,0,0.373768090184884,46.2933622160075,5.53273344205396,{"v":3.37762800023199e-05,"d":"3.38E-05"},0.00116667196700507,"up","yes","LOC104975686","protein_coding","chrNC_037350.1:31843578-31845873:+","gi|741900492|ref|XP_010823716.1|",848,{"v":6e-105,"d":"6.00E-105"},"PREDICTED: LOW QUALITY PROTEIN: histone H1t [Bos taurus]","gi|983005674|ref|XM_010825414.2|",2287,0,"PREDICTED: Bos taurus histone H1t (LOC104975686), mRNA","P40286",202,{"v":4e-58,"d":"4.00E-58"},"Histone H1t",".",".",".",".","pfam00538","Linker_histone","linker histone H1 and H5 family. Linker histone H1 is an essential component of chromatin structure. H1 links nucleosomes into higher order structures Histone H1 is replaced by histone H5 in some cell types.","GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0006334|nucleosome assembly;GO:0007283|spermatogenesis;","GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;","K11275","H1_5; histone H1/5"]
["gene28604",15,32,21,20.8458685929242,3,2,3,2.93819807389327,7.094779885041,2.82675792548585,0.00170912226053092,0.027483237654022,"up","yes","HIST1H2BB","protein_coding","chrNC_037350.1:31884527-31885243:+","gi|61835422|ref|XP_603865.1|",481,{"v":8e-58,"d":"8.00E-58"},"PREDICTED: histone H2B type 1-B [Bos taurus]","gi|983005687|ref|XM_603865.4|",651,0,"PREDICTED: Bos taurus histone cluster 1, H2bb (HIST1H2BB), mRNA","P10853",189,{"v":7e-59,"d":"7.00E-59"},"Histone H2B type 1-F/J/L",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0019731|antibacterial humoral response;GO:0050830|defense response to Gram-positive bacterium;GO:0002227|innate immune response in mucosa;GO:0006334|nucleosome assembly;","GO:0005829|cytosol;GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0046982|protein heterodimerization activity;","K11252","H2B; histone H2B"]
["gene28618",0,225,5,75.2720859895236,0,1,0,0.366987568989444,205.107999153204,7.68023994738294,{"v":5.56860128102567e-17,"d":"5.57E-17"},{"v":2.56254456691844e-14,"d":"2.56E-14"},"up","yes","HIST1H2BA","protein_coding","chrNC_037350.1:32152809-32153696:+","gi|440908952|gb|ELR58921.1|",516,{"v":3e-62,"d":"3.00E-62"},"hypothetical protein M91_11375, partial [Bos mutus]","gi|983005619|ref|XM_010825421.2|",888,0,"PREDICTED: Bos taurus histone cluster 1, H2ba (HIST1H2BA), mRNA","Q00729",195,{"v":1e-60,"d":"1.00E-60"},"Histone H2B type 1-A",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006954|inflammatory response;GO:0071674|mononuclear cell migration;GO:0006334|nucleosome assembly;GO:0006337|nucleosome disassembly;GO:0031639|plasminogen activation;GO:0051099|positive regulation of binding;GO:0035093|spermatogenesis, exchange of chromosomal proteins;","GO:0019897|extrinsic component of plasma membrane;GO:0000788|nuclear nucleosome;GO:0000786|nucleosome;","GO:0003677|DNA binding;GO:0042393|histone binding;GO:0046982|protein heterodimerization activity;","K11252","H2B; histone H2B"]
["gene28619",0,60,0,19.6630607523955,0,0,0,0,"Inf","Inf",{"v":1.86133909226924e-06,"d":"1.86E-06"},0.000103318804750066,"up","yes","HIST1H2BA","protein_coding","chrNC_037350.1:32155953-32156540:-","gi|982964673|ref|XP_015315477.1|",868,{"v":3e-116,"d":"3.00E-116"},"PREDICTED: histone H2B type 1-A [Bos taurus]","gi|983005615|ref|XM_015469001.1|",588,0,"PREDICTED: Bos taurus histone cluster 1, H2ba (HIST1H2BA), mRNA","Q00729",217,{"v":1e-70,"d":"1.00E-70"},"Histone H2B type 1-A",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006954|inflammatory response;GO:0071674|mononuclear cell migration;GO:0006334|nucleosome assembly;GO:0006337|nucleosome disassembly;GO:0031639|plasminogen activation;GO:0051099|positive regulation of binding;GO:0035093|spermatogenesis, exchange of chromosomal proteins;","GO:0019897|extrinsic component of plasma membrane;GO:0000788|nuclear nucleosome;GO:0000786|nucleosome;","GO:0003677|DNA binding;GO:0042393|histone binding;GO:0046982|protein heterodimerization activity;","K11252","H2B; histone H2B"]
["gene2862",1757,1519,1549,1431.44959229499,492,624,635,642.111927588185,2.2292836042956,1.15658016459403,{"v":4.28259577695536e-06,"d":"4.28E-06"},0.000206048465619416,"up","yes","PBX1","protein_coding","chrNC_037330.1:4146907-4481111:-","gi|7110681|ref|NP_032809.1|",1695,0,"pre-B-cell leukemia transcription factor 1 isoform b [Mus musculus]","gi|982915923|ref|XM_005203439.3|",6423,0,"PREDICTED: Bos taurus pre-B-cell leukemia homeobox 1 (PBX1), transcript variant X2, mRNA","P41778",629,0,"Pre-B-cell leukemia transcription factor 1",".",".",".",".","pfam03792","PBC","PBC domain. The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.","GO:0030325|adrenal gland development;GO:0009887|organ morphogenesis;GO:0009952|anterior/posterior pattern specification;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0035162|embryonic hemopoiesis;GO:0030326|embryonic limb morphogenesis;GO:0048568|embryonic organ development;GO:0048706|embryonic skeletal system development;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0045665|negative regulation of neuron differentiation;GO:0008284|positive regulation of cell proliferation;GO:0010971|positive regulation of G2/M transition of mitotic cell cycle;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0009954|proximal/distal pattern formation;GO:0042127|regulation of cell proliferation;GO:0030278|regulation of ossification;GO:0007548|sex differentiation;GO:0048536|spleen development;GO:0006694|steroid biosynthetic process;GO:0048538|thymus development;GO:0001655|urogenital system development;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0090575|RNA polymerase II transcription factor complex;GO:0005667|transcription factor complex;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09355","PBX1; pre-B-cell leukemia transcription factor 1"]
["gene28649",36,51,39,38.0737818763558,9,2,3,5.18080661500257,7.34900657478737,2.87754924226291,0.00386912372148936,0.0496581056670323,"up","yes","LOC788801","protein_coding","chrNC_037350.1:34453682-34454564:-","gi|982928986|ref|XP_015327242.1|",1037,{"v":2e-136,"d":"2.00E-136"},"PREDICTED: histone RNA hairpin-binding protein isoform X1 [Bos taurus]","gi|983005713|ref|XM_003583919.4|",883,0,"PREDICTED: Bos taurus ferritin light chain (LOC788801), mRNA","O46415",358,{"v":5e-124,"d":"5.00E-124"},"Ferritin light chain","TM1128",68.9,{"v":2e-13,"d":"2.00E-13"},"COG1528","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006880|intracellular sequestering of iron ion;GO:0006826|iron ion transport;","GO:0005737|cytoplasm;GO:0008043|intracellular ferritin complex;","GO:0008199|ferric iron binding;GO:0005506|iron ion binding;","K13625","FTL; ferritin light chain"]
["gene2868",11160,1117,1778,3820.67823532109,1481,1627,1399,1655.64038725572,2.30767397602204,1.206439417051,{"v":4.96104003134547e-06,"d":"4.96E-06"},0.000233956087825318,"up","yes","RGS5","protein_coding","chrNC_037330.1:6159079-6212129:+","gi|77736359|ref|NP_001029879.1|",844,{"v":2e-105,"d":"2.00E-105"},"regulator of G-protein signaling 5 [Bos taurus]","gi|402692497|ref|NM_001034707.2|",2111,0,"Bos taurus regulator of G-protein signaling 5 (RGS5), mRNA","Q3T0T8",329,{"v":8e-107,"d":"8.00E-107"},"Regulator of G-protein signaling 5",".",".",".",".","pfam00615","RGS","Regulator of G protein signaling domain. RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.","GO:0009968|negative regulation of signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005096|GTPase activator activity;","K16449","RGS; regulator of G-protein signaling"]
["gene28685",0,73,0,23.9233905820812,0,0,0,0,"Inf","Inf",{"v":1.67441281795713e-07,"d":"1.67E-07"},{"v":1.30629790997099e-05,"d":"1.31E-05"},"up","yes","HDGFL1","protein_coding","chrNC_037350.1:35662146-35664136:-","gi|83721975|ref|NP_001001136.2|",897,{"v":6e-113,"d":"6.00E-113"},"hepatoma-derived growth factor-like protein 1 [Bos taurus]","gi|402744075|ref|NM_001001136.3|",1988,0,"Bos taurus hepatoma derived growth factor-like 1 (HDGFL1), mRNA","P51859",199,{"v":3e-57,"d":"3.00E-57"},"Hepatoma-derived growth factor",".",".",".",".","pfam00855","PWWP","PWWP domain. The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organizing higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression.","GO:0009987|cellular process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0034504|protein localization to nucleus;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0017053|transcriptional repressor complex;","GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0000166|nucleotide binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001106|RNA polymerase II transcription corepressor activity;GO:0001222|transcription corepressor binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K16641","HDGF; hepatoma-derived growth factor"]
["gene2872",45,40,49,39.8857128726902,7,11,12,10.984914551617,3.63095340298472,1.860348415758,0.003618316393702,0.0474231343268941,"up","yes","CCDC190","protein_coding","chrNC_037330.1:6567494-6576468:+","gi|528941891|ref|XP_005203607.1|",1410,0,"PREDICTED: coiled-coil domain-containing protein 190 isoform X1 [Bos taurus]","gi|982916054|ref|XM_005203550.3|",1875,0,"PREDICTED: Bos taurus coiled-coil domain containing 190 (CCDC190), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam14391","DUF4421","Domain of unknown function (DUF4421). This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 336 and 370 amino acids in length.",".",".",".",".","."]
["gene28731",1930,2606,2279,2056.96532209913,555,959,760,833.721763937951,2.4672083794279,1.30287957022719,0.000135798757309519,0.00375433560542431,"up","yes","ATXN1","protein_coding","chrNC_037350.1:40415586-40828846:+","gi|529004138|ref|XP_005223892.1|",3492,0,"PREDICTED: ataxin-1 isoform X2 [Bos taurus]","gi|983005774|ref|XM_015469032.1|",3985,0,"PREDICTED: Bos taurus ataxin 1 (ATXN1), transcript variant X16, mRNA","P54253",1113,0,"Ataxin-1",".",".",".",".","pfam08517","AXH","Ataxin-1 and HBP1 module (AXH). AXH is a protein-protein and RNA binding motif found in Ataxin-1 (ATX1). ATX1 is responsible for the autosomal-dominant neurodegenerative disorder Spinocerebellar ataxia type-1 (SCA1) in humans. The AXH module has also been identified in the apparently unrelated transcription factor HBP1 which is thought to be involved in the architectural regulation of chromatin and in specific gene expression.","GO:0007420|brain development;GO:0007612|learning;GO:0007613|memory;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051168|nuclear export;GO:0006396|RNA processing;GO:0035176|social behavior;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0042405|nuclear inclusion body;GO:0016363|nuclear matrix;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0042802|identical protein binding;GO:0034046|poly(G) binding;GO:0008266|poly(U) RNA binding;GO:0008022|protein C-terminus binding;GO:0043621|protein self-association;",".","."]
["gene28732",572,464,435,434.735405241696,122,156,133,150.85916192919,2.88173021566798,1.52693527835223,{"v":3.14150506309343e-07,"d":"3.14E-07"},{"v":2.24264869959996e-05,"d":"2.24E-05"},"up","yes","LOC574091","protein_coding","chrNC_037350.1:40831987-40833465:+","gi|70778740|ref|NP_001020518.1|",621,{"v":1e-75,"d":"1.00E-75"},"nucleoside-diphosphate kinase NBR-A [Bos taurus]","gi|70778739|ref|NM_001025347.1|",1475,0,"Bos taurus nucleoside-diphosphate kinase NBR-A (LOC574091), mRNA",".",".",".",".",".",".",".",".","pfam08710","nsp9","nsp9 replicase. nsp9 is a single-stranded RNA-binding viral protein likely to be involved in RNA synthesis. Its structure comprises of a single beta barrel.",".",".",".",".","."]
["gene28736",929,729,983,782.92574099921,237,367,319,338.417826609528,2.31348847323744,1.2100699108139,{"v":1.67774187544379e-05,"d":"1.68E-05"},0.000655774980821891,"up","yes","JARID2","protein_coding","chrNC_037350.1:41485616-41715084:-","gi|358418559|ref|XP_003583974.1|",5489,0,"PREDICTED: protein Jumonji isoform X1 [Bos taurus]","gi|983005786|ref|XM_005196696.3|",4975,0,"PREDICTED: Bos taurus jumonji and AT-rich interaction domain containing 2 (JARID2), transcript variant X4, mRNA","Q92833",1966,0,"Protein Jumonji",".",".",".",".","pfam02373","JmjC","JmjC domain, hydroxylase. The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyse a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalyzing hydroxylation.","GO:1990830|cellular response to leukemia inhibitory factor;GO:0007417|central nervous system development;GO:0006325|chromatin organization;GO:0001889|liver development;GO:0060044|negative regulation of cardiac muscle cell proliferation;GO:0010614|negative regulation of cardiac muscle hypertrophy;GO:0045814|negative regulation of gene expression, epigenetic;GO:0031061|negative regulation of histone methylation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051574|positive regulation of histone H3-K9 methylation;GO:0048536|spleen development;GO:0048863|stem cell differentiation;GO:0048538|thymus development;GO:0006351|transcription, DNA-templated;","GO:0035098|ESC/E(Z) complex;GO:0035097|histone methyltransferase complex;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0001227|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K11478","JARID2, JMJ; protein Jumonji"]
["gene28751",3022,3155,2477,2582.2929860631,550,503,517,576.790180133703,4.47700580731889,2.16253418962513,{"v":1.05989758779995e-18,"d":"1.06E-18"},{"v":6.2999870994834e-16,"d":"6.30E-16"},"up","yes","GFOD1","protein_coding","chrNC_037350.1:43100553-43204052:+","gi|555985353|ref|XP_005904554.1|",2087,0,"PREDICTED: glucose-fructose oxidoreductase domain-containing protein 1 isoform X1 [Bos mutus]","gi|983005797|ref|XM_015469034.1|",8384,0,"PREDICTED: Bos taurus glucose-fructose oxidoreductase domain-containing protein 1 (LOC104968712), transcript variant X2, mRNA","Q3UHD2",800,0,"Glucose-fructose oxidoreductase domain-containing protein 1",".",".",".",".","pfam01408","GFO_IDH_MocA","Oxidoreductase family, NAD-binding Rossmann fold. This family of enzymes utilize NADP or NAD. This family is called the GFO/IDH/MOCA family in swiss-prot.",".","GO:0005576|extracellular region;","GO:0016491|oxidoreductase activity;",".","."]
["gene28800",2688,3587,3277,2882.51616926353,1070,1237,1203,1288.14586414702,2.23772497315144,1.16203273325238,{"v":3.06460996854475e-06,"d":"3.06E-06"},0.000155580759808808,"up","yes","RREB1","protein_coding","chrNC_037350.1:48048382-48215277:-","gi|529004367|ref|XP_003587789.2|",6482,0,"PREDICTED: ras-responsive element-binding protein 1 isoform X1 [Bos taurus]","gi|983005885|ref|XM_015469053.1|",4302,0,"PREDICTED: Bos taurus ras responsive element binding protein 1 (RREB1), transcript variant X2, mRNA","Q92766",1671,0,"Ras-responsive element-binding protein 1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0007275|multicellular organismal development;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0010634|positive regulation of epithelial cell migration;GO:2000394|positive regulation of lamellipodium morphogenesis;GO:0033601|positive regulation of mammary gland epithelial cell proliferation;GO:1900026|positive regulation of substrate adhesion-dependent cell spreading;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:1903691|positive regulation of wound healing, spreading of epidermal cells;GO:0007265|Ras protein signal transduction;GO:0006355|regulation of transcription, DNA-templated;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0001650|fibrillar center;GO:0016604|nuclear body;GO:0016607|nuclear speck;GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0000979|RNA polymerase II core promoter sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;",".","."]
["gene28833",1080,1409,1428,1181.79699857757,331,399,370,403.705246605684,2.92737587265463,1.54960799849687,{"v":1.46285293856516e-09,"d":"1.46E-09"},{"v":1.88853652444355e-07,"d":"1.89E-07"},"up","yes","SLC22A23","protein_coding","chrNC_037350.1:50327909-50461349:+","gi|803333468|ref|XP_012024835.1|",2804,0,"PREDICTED: solute carrier family 22 member 23 isoform X2 [Ovis aries musimon]","gi|982964784|ref|XM_005223883.3|",4204,0,"PREDICTED: Bos taurus solute carrier family 22 member 23 (SLC22A23), transcript variant X1, mRNA","Q3UHH2",960,0,"Solute carrier family 22 member 23",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.",".","GO:0016021|integral component of membrane;","GO:0008514|organic anion transmembrane transporter activity;","K08215","SLC22A23; MFS transporter, OCT family, solute carrier family 22 (organic anion transporter), member 23"]
["gene28856",3187,2623,1743,2225.52273573482,38,119,59,79.1721085555107,28.1099338686226,4.81300815452798,{"v":2.40177244910415e-11,"d":"2.40E-11"},{"v":4.4209657900252e-09,"d":"4.42E-09"},"up","yes","MYLK4","protein_coding","chrNC_037350.1:50879200-50949678:+","gi|741900858|ref|XP_010797797.1|",1935,0,"PREDICTED: myosin light chain kinase family member 4 isoform X1 [Bos taurus]","gi|983005933|ref|XM_010799496.2|",2472,0,"PREDICTED: Bos taurus myosin light chain kinase family member 4 (MYLK4), transcript variant X2, mRNA","Q86YV6",644,0,"Myosin light chain kinase family member 4",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;","GO:0005622|intracellular;","GO:0005524|ATP binding;GO:0004687|myosin light chain kinase activity;","K00907","MYLK; myosin-light-chain kinase [EC:2.7.11.18]"]
["gene28863",15,7,9,8.96746700946223,0,0,0,0,"Inf","Inf",0.000912458155835132,0.0168282764344746,"up","yes","FOXF2","protein_coding","chrNC_037350.1:51700547-51705418:-","gi|983005814|ref|XP_015324527.1|",1217,{"v":6e-156,"d":"6.00E-156"},"PREDICTED: forkhead box protein F2 isoform X2 [Bos taurus]","gi|983005813|ref|XM_015469041.1|",2021,0,"PREDICTED: Bos taurus forkhead box F2 (FOXF2), transcript variant X2, mRNA","O54743",446,{"v":2e-148,"d":"2.00E-148"},"Forkhead box protein F2","SPBC4C3.05",85.9,{"v":2e-16,"d":"2.00E-16"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0030154|cell differentiation;GO:0048596|embryonic camera-type eye morphogenesis;GO:0048566|embryonic digestive tract development;GO:0042249|establishment of planar polarity of embryonic epithelium;GO:0030198|extracellular matrix organization;GO:0048806|genitalia development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060021|palate development;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0008134|transcription factor binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09399","FOXF; forkhead box protein F"]
["gene28907",2389,6085,3944,3828.07871372417,1126,1682,1526,1588.98058836807,2.40914127066569,1.26851899486863,{"v":3.61131439909404e-06,"d":"3.61E-06"},0.000177645536414745,"up","yes","NFATC1","protein_coding","chrNC_037351.1:779624-867293:-","gi|594113811|ref|XP_006079647.1|",3825,0,"PREDICTED: nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [Bubalus bubalis]","gi|594113810|ref|XM_006079585.1|",4420,0,"PREDICTED: Bubalus bubalis nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATC1), transcript variant X1, mRNA","P98201",1281,0,"Nuclear factor of activated T-cells, cytoplasmic 1",".",".",".",".","pfam00554","RHD","Rel homology domain (RHD). Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam01833) that binds to DNA.","GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;",".","."]
["gene28917",306,280,143,215.430054255685,62,59,58,65.762315692128,3.27588911656091,1.71188652495968,{"v":1.59991731769057e-06,"d":"1.60E-06"},{"v":9.16611264880113e-05,"d":"9.17E-05"},"up","yes","MBP","protein_coding","chrNC_037351.1:2224045-2328579:+","gi|529004475|ref|XP_005223993.1|",1879,0,"PREDICTED: myelin basic protein isoform X3 [Bos taurus]","gi|982965000|ref|XM_005223936.3|",2718,0,"PREDICTED: Bos taurus myelin basic protein (MBP), transcript variant X3, mRNA","P02686",504,{"v":4e-170,"d":"4.00E-170"},"Myelin basic protein",".",".",".",".","pfam01669","Myelin_MBP","Myelin basic protein.","GO:0008366|axon ensheathment;GO:0007417|central nervous system development;GO:0007268|synaptic transmission;GO:0006955|immune response;GO:0035633|maintenance of blood-brain barrier;GO:0000165|MAPK cascade;GO:0061024|membrane organization;GO:0042552|myelination;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:1904209|positive regulation of chemokine (C-C motif) ligand 2 secretion;GO:2000778|positive regulation of interleukin-6 secretion;GO:1904685|positive regulation of metalloendopeptidase activity;GO:0009636|response to toxic substance;GO:0007605|sensory perception of sound;GO:0021762|substantia nigra development;","GO:0071944|cell periphery;GO:0043218|compact myelin;GO:0033269|internode region of axon;GO:0005622|intracellular;GO:0043209|myelin sheath;GO:0043025|neuronal cell body;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0005516|calmodulin binding;GO:0002020|protease binding;GO:0019911|structural constituent of myelin sheath;","K17269","MBP; myelin basic protein"]
["gene28924",718,1616,1024,1031.21180646095,318,213,264,292.323447425201,3.5276397276507,1.81870322822193,{"v":4.29545735815453e-10,"d":"4.30E-10"},{"v":6.34993232567393e-08,"d":"6.35E-08"},"up","yes","ZNF516","protein_coding","chrNC_037351.1:2551257-2651584:+","gi|528924790|ref|XP_597668.4|",4865,0,"PREDICTED: zinc finger protein 516 isoform X1 [Bos taurus]","gi|983006031|ref|XM_597668.6|",7631,0,"PREDICTED: Bos taurus zinc finger protein 516 (ZNF516), transcript variant X1, mRNA","Q92618",1355,0,"Zinc finger protein 516","ECU03g0790",58.2,{"v":4e-08,"d":"4.00E-08"},"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0060612|adipose tissue development;GO:0050873|brown fat cell differentiation;GO:0007275|multicellular organismal development;GO:0045893|positive regulation of transcription, DNA-templated;GO:0009409|response to cold;GO:0007165|signal transduction;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0033613|activating transcription factor binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0044212|transcription regulatory region DNA binding;",".","."]
["gene28998",826,516,639,580.627839972889,213,196,223,232.039120856384,2.50228426064524,1.32324568963501,{"v":2.26146018608907e-06,"d":"2.26E-06"},0.000121509831580616,"up","yes","MOCOS","protein_coding","chrNC_037351.1:20886491-20946894:-","gi|550544301|sp|Q9N0E7.3|MOCOS_BOVIN",4583,0,"RecName: Full=Molybdenum cofactor sulfurase; Short=MCS; Short=MOS; Short=MoCo sulfurase; AltName: Full=Molybdenum cofactor sulfurtransferase","gi|926722526|ref|XM_013974245.1|",3676,0,"PREDICTED: Capra hircus molybdenum cofactor sulfurase (MOCOS), mRNA","Q9N0E7",1767,0,"Molybdenum cofactor sulfurase","MA1950",239,{"v":1e-66,"d":"1.00E-66"},"COG0520","pfam03476","MOSC_N","MOSC N-terminal beta barrel domain. This domain is found to the N-terminus of pfam03473. The function of this domain is unknown, however it is predicted to adopt a beta barrel fold.","GO:0006777|Mo-molybdopterin cofactor biosynthetic process;GO:0043545|molybdopterin cofactor metabolic process;",".","GO:0008265|Mo-molybdopterin cofactor sulfurase activity;GO:0030151|molybdenum ion binding;GO:0030170|pyridoxal phosphate binding;","K15631","ABA3; molybdenum cofactor sulfurtransferase [EC:2.8.1.9]"]
["gene29041",52,110,194,109.18294994818,1,1,0,0.740755659174328,147.394013931502,7.20353412366021,{"v":1.29680750231539e-22,"d":"1.30E-22"},{"v":1.32140053030573e-19,"d":"1.32E-19"},"up","yes","DSG4","protein_coding","chrNC_037351.1:25725711-25755364:-","gi|119916147|ref|XP_617938.3|",4827,0,"PREDICTED: desmoglein-4 isoform X1 [Bos taurus]","gi|983006138|ref|XM_015469098.1|",5142,0,"PREDICTED: Bos taurus desmoglein 4 (DSG4), transcript variant X2, mRNA","Q86SJ6",1606,0,"Desmoglein-4",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0030509|BMP signaling pathway;GO:0070268|cornification;GO:0001942|hair follicle development;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0031424|keratinization;","GO:0001533|cornified envelope;GO:0030057|desmosome;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;","K07599","DSG4; desmoglein 4"]
["gene29055",13,44,27,26.0999640713795,5,3,4,4.41369471170572,5.91340493083013,2.56398907157208,0.00141341976114283,0.0237353026516575,"up","yes","CHST9","protein_coding","chrNC_037351.1:29688823-29967360:+","gi|529004835|ref|XP_005224123.1|",2298,0,"PREDICTED: carbohydrate sulfotransferase 9 isoform X1 [Bos taurus]","gi|982965332|ref|XM_005224066.3|",2829,0,"PREDICTED: Bos taurus carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 (CHST9), transcript variant X1, mRNA","Q7L1S5",753,0,"Carbohydrate sulfotransferase 9",".",".",".",".","pfam03567","Sulfotransfer_2","Sulfotransferase family. This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyses the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.","GO:0016051|carbohydrate biosynthetic process;GO:0030206|chondroitin sulfate biosynthetic process;GO:0030203|glycosaminoglycan metabolic process;GO:0042446|hormone biosynthetic process;GO:0030166|proteoglycan biosynthetic process;GO:0006790|sulfur compound metabolic process;","GO:0005576|extracellular region;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0047756|chondroitin 4-sulfotransferase activity;GO:0001537|N-acetylgalactosamine 4-O-sulfotransferase activity;","K09673","CHST9; carbohydrate 4-sulfotransferase 9 [EC:2.8.2.-]"]
["gene29076",621,333,295,361.577899165472,85,115,92,107.183363837199,3.37345168336639,1.7542254988261,{"v":1.91464011349859e-08,"d":"1.91E-08"},{"v":1.8941154195917e-06,"d":"1.89E-06"},"up","yes","LAMA3","protein_coding","chrNC_037351.1:32710617-32971608:-","gi|983006190|ref|XP_015324602.1|",17175,0,"PREDICTED: LOW QUALITY PROTEIN: laminin subunit alpha-3 isoform X2 [Bos taurus]","gi|983006189|ref|XM_015469116.1|",10336,0,"PREDICTED: Bos taurus laminin subunit alpha 3 (LAMA3), transcript variant X2, mRNA","Q16787",5515,0,"Laminin subunit alpha-3",".",".",".",".","pfam06008","Laminin_I","Laminin Domain I. coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.","GO:0007155|cell adhesion;GO:0035987|endodermal cell differentiation;GO:0008544|epidermis development;GO:0030198|extracellular matrix organization;GO:0031581|hemidesmosome assembly;GO:0030155|regulation of cell adhesion;GO:0030334|regulation of cell migration;GO:0045995|regulation of embryonic development;","GO:0005604|basement membrane;GO:0005783|endoplasmic reticulum;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005610|laminin-5 complex;","GO:0005102|receptor binding;GO:0005198|structural molecule activity;","K06240","LAMA3_5; laminin, alpha 3/5"]
["gene29093",231,47,49,90.6556586786716,27,19,20,24.2839600148561,3.73314972612422,1.90039337223731,{"v":9.34745064467912e-05,"d":"9.35E-05"},0.00275953353553476,"up","yes","GATA6","protein_coding","chrNC_037351.1:34161957-34194205:-","gi|803294256|ref|XP_012006784.1|",1910,0,"PREDICTED: transcription factor GATA-6 [Ovis aries musimon]","gi|965877588|ref|XM_012151397.2|",3039,0,"PREDICTED: Ovis aries musimon GATA binding protein 6 (GATA6), transcript variant X4, mRNA","Q92908",695,0,"Transcription factor GATA-6","SPCC1393.08",114,{"v":1e-25,"d":"1.00E-25"},"COG5641","pfam05349","GATA-N","GATA-type transcription activator, N-terminal. GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.","GO:0048645|organ formation;GO:0007596|blood coagulation;GO:0055007|cardiac muscle cell differentiation;GO:0014898|cardiac muscle hypertrophy in response to stress;GO:0060947|cardiac vascular smooth muscle cell differentiation;GO:0044267|cellular protein metabolic process;GO:0071773|cellular response to BMP stimulus;GO:0071371|cellular response to gonadotropin stimulus;GO:0071456|cellular response to hypoxia;GO:0060486|Clara cell differentiation;GO:0007493|endodermal cell fate determination;GO:0001701|in utero embryonic development;GO:0060575|intestinal epithelial cell differentiation;GO:0001889|liver development;GO:0060430|lung saccule development;GO:0008584|male gonad development;GO:0043066|negative regulation of apoptotic process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0032911|negative regulation of transforming growth factor beta1 production;GO:0032912|negative regulation of transforming growth factor beta2 production;GO:0003148|outflow tract septum morphogenesis;GO:0003310|pancreatic A cell differentiation;GO:0006644|phospholipid metabolic process;GO:0045766|positive regulation of angiogenesis;GO:0030513|positive regulation of BMP signaling pathway;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0051891|positive regulation of cardioblast differentiation;GO:0071158|positive regulation of cell cycle arrest;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0042493|response to drug;GO:0043627|response to estrogen;GO:0070848|response to growth factor;GO:0051145|smooth muscle cell differentiation;GO:0006366|transcription from RNA polymerase II promoter;GO:0035239|tube morphogenesis;GO:0003309|type B pancreatic cell differentiation;GO:0060510|Type II pneumocyte differentiation;","GO:0031965|nuclear membrane;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003682|chromatin binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019901|protein kinase binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0001103|RNA polymerase II repressing transcription factor binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001085|RNA polymerase II transcription factor binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0008134|transcription factor binding;GO:0044212|transcription regulatory region DNA binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;GO:0008270|zinc ion binding;","K17897","GATA6; GATA-binding protein 6"]
["gene29157",1013,265,401,474.012298981678,177,241,186,221.741913341483,2.13767569621219,1.09604300041355,0.000251946892639634,0.00604566593263364,"up","yes","ARHGAP28","protein_coding","chrNC_037351.1:39797862-39937581:+","gi|741972944|ref|XP_010817247.1|",3950,0,"PREDICTED: rho GTPase-activating protein 28 isoform X1 [Bos taurus]","gi|983006320|ref|XM_010825549.2|",6126,0,"PREDICTED: Bos taurus Rho GTPase activating protein 28 (ARHGAP28), transcript variant X1, mRNA","Q9P2N2",1184,0,"Rho GTPase-activating protein 28",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:1904425|negative regulation of GTP binding;GO:0051497|negative regulation of stress fiber assembly;GO:0051056|regulation of small GTPase mediated signal transduction;GO:0007165|signal transduction;","GO:0005829|cytosol;","GO:0005096|GTPase activator activity;",".","."]
["gene29160",1264,2367,1970,1710.16513625093,365,776,512,606.025825341351,2.82193442051361,1.49668446125228,0.00161464637552769,0.0263297357864248,"up","yes","LRRC30","protein_coding","chrNC_037351.1:40126526-40129349:+","gi|332205894|ref|NP_001095980.2|",1319,{"v":1e-171,"d":"1.00E-171"},"leucine-rich repeat-containing protein 30 [Bos taurus]","gi|156523131|ref|NM_001102510.1|",2824,0,"Bos taurus leucine rich repeat containing 30 (LRRC30), mRNA",".",".",".",".","alr0124_1",99,{"v":8e-21,"d":"8.00E-21"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".",".",".",".","."]
["gene29185",383,170,89,182.864530564511,58,35,39,48.6010567950303,3.76256284581881,1.91171567930594,{"v":7.5249384460169e-07,"d":"7.52E-07"},{"v":4.73938231353881e-05,"d":"4.74E-05"},"up","yes","PIEZO2","protein_coding","chrNC_037351.1:42199199-42451988:-","gi|529005413|ref|XP_003587835.2|",12430,0,"PREDICTED: piezo-type mechanosensitive ion channel component 2 [Bos taurus]","gi|983006387|ref|XM_003583977.4|",9593,0,"PREDICTED: Bos taurus piezo-type mechanosensitive ion channel component 2 (PIEZO2), transcript variant X1, mRNA","Q9H5I5",4488,0,"Piezo-type mechanosensitive ion channel component 2",".",".",".",".","pfam12166","DUF3595","Protein of unknown function (DUF3595). This family of proteins is functionally uncharacterized.This family of proteins is found in eukaryotes. Proteins in this family are typically between 578 and 2525 amino acids in length.","GO:0006812|cation transport;GO:0071260|cellular response to mechanical stimulus;GO:0050982|detection of mechanical stimulus;GO:0050974|detection of mechanical stimulus involved in sensory perception;GO:0042391|regulation of membrane potential;GO:0009612|response to mechanical stimulus;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005261|cation channel activity;GO:0008381|mechanically-gated ion channel activity;",".","."]
["gene29206",9,97,132,74.6742796508347,10,6,5,7.74447075805171,9.64227020590115,3.26937285902803,{"v":1.65554702874647e-08,"d":"1.66E-08"},{"v":1.66906050449348e-06,"d":"1.67E-06"},"up","yes","LOC100335744","pseudogene","chrNC_037351.1:43153593-43153902:-","gi|528957635|ref|XP_005209785.1|",311,{"v":4e-35,"d":"4.00E-35"},"PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial [Bos taurus]","gi|942077191|ref|XM_005903300.2|",295,{"v":8e-152,"d":"8.00E-152"},"PREDICTED: Bos mutus cytochrome c oxidase subunit 7C, mitochondrial (LOC102284257), mRNA","P00430",124,{"v":1e-36,"d":"1.00E-36"},"Cytochrome c oxidase subunit 7C, mitochondrial",".",".",".",".","pfam02935","COX7C","Cytochrome c oxidase subunit VIIc. Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIIc. The yeast member of this family is called COX VIII.","GO:0006123|mitochondrial electron transport, cytochrome c to oxygen;","GO:0016021|integral component of membrane;GO:0005751|mitochondrial respiratory chain complex IV;GO:0045277|respiratory chain complex IV;","GO:0004129|cytochrome-c oxidase activity;","K02272","COX7C; cytochrome c oxidase subunit 7c"]
["gene29278",193,96,50,97.1172635936267,32,43,28,37.8482852291532,2.56596205100517,1.35949983401625,0.0021128210341182,0.0320132219460575,"up","yes","MYO5B","protein_coding","chrNC_037351.1:49490075-49824876:-","gi|529005541|ref|XP_002697867.2|",9291,0,"PREDICTED: unconventional myosin-Vb isoform X1 [Bos taurus]","gi|983006499|ref|XM_015469176.1|",5730,0,"PREDICTED: Bos taurus myosin VB (MYO5B), transcript variant X1, mRNA","Q9ULV0",3268,0,"Unconventional myosin-Vb","YOR326w",849,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0016197|endosomal transport;GO:0007018|microtubule-based movement;GO:0015031|protein transport;GO:0003091|renal water homeostasis;GO:0016192|vesicle-mediated transport;","GO:0045179|apical cortex;GO:0030659|cytoplasmic vesicle membrane;GO:0070062|extracellular exosome;GO:0016459|myosin complex;GO:0032991|macromolecular complex;","GO:0051015|actin filament binding;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0000146|microfilament motor activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0017137|Rab GTPase binding;","K10357","MYO5; myosin V"]
["gene29363",617,168,105,248.108878763501,66,94,100,95.2628142825343,2.60446723763219,1.38098828911286,{"v":9.4622954044435e-05,"d":"9.46E-05"},0.00277852151318245,"up","yes","RNF152","protein_coding","chrNC_037351.1:60303200-60382130:-","gi|594082012|ref|XP_006064616.1|",890,{"v":3e-105,"d":"3.00E-105"},"PREDICTED: E3 ubiquitin-protein ligase RNF152 [Bubalus bubalis]","gi|926723174|ref|XM_013974475.1|",2998,0,"PREDICTED: Capra hircus ring finger protein 152 (RNF152), mRNA","D2H6Z0",322,{"v":4e-98,"d":"4.00E-98"},"E3 ubiquitin-protein ligase RNF152",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0006915|apoptotic process;GO:0034198|cellular response to amino acid starvation;GO:1904262|negative regulation of TORC1 signaling;GO:0010508|positive regulation of autophagy;GO:0070936|protein K48-linked ubiquitination;GO:0070534|protein K63-linked ubiquitination;","GO:0031301|integral component of organelle membrane;GO:0005765|lysosomal membrane;GO:0005764|lysosome;","GO:0046872|metal ion binding;GO:0031267|small GTPase binding;GO:0061630|ubiquitin protein ligase activity;GO:0004842|ubiquitin-protein transferase activity;","K15705","RNF152; E3 ubiquitin-protein ligase RNF152 [EC:2.3.2.27]"]
["gene29400",0,1433,1588,957.328588472711,0,3,0,1.10096270696833,869.53770769299,9.76410478144933,0.000176658445446031,0.00459943245060179,"up","yes","LOC789192","protein_coding","chrNC_037352.1:35707-39689:+","gi|741901678|ref|XP_010823991.1|",1046,{"v":4e-138,"d":"4.00E-138"},"PREDICTED: cyclin-G1, partial [Bos taurus]","gi|983006638|ref|XM_010825689.2|",1445,0,"PREDICTED: Bos taurus cyclin-G1 (LOC789192), partial mRNA","Q5E9I1",402,{"v":2e-136,"d":"2.00E-136"},"Cyclin-G1",".",".",".",".","pfam00134","Cyclin_N","Cyclin, N-terminal domain. Cyclins regulate cyclin dependent kinases (CDKs). Human cyclin-O is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.","GO:0007049|cell cycle;GO:0051301|cell division;GO:0051726|regulation of cell cycle;","GO:0005634|nucleus;",".","K10145","CCNG1; cyclin G1"]
["gene29415",567,1553,1328,1064.57646052553,425,390,432,457.916878046259,2.32482468230399,1.21712192503475,{"v":5.98224652548495e-06,"d":"5.98E-06"},0.000275095180402132,"up","yes","FAM234A","protein_coding","chrNC_037352.1:276261-296400:+","gi|115496776|ref|NP_001068786.1|",2683,0,"protein ITFG3 [Bos taurus]","gi|982965974|ref|XM_005200983.3|",2517,0,"PREDICTED: Bos taurus family with sequence similarity 234 member A (FAM234A), transcript variant X1, mRNA","Q2HJE5",1038,0,"Protein FAM234A",".",".",".",".","pfam13360","PQQ_2","PQQ-like domain. This domain contains several repeats of the PQQ repeat.",".","GO:0016021|integral component of membrane;",".","K17258","ITFG3; integrin alpha FG-GAP repeat containing protein 3"]
["gene29524",1117,2516,1893,1697.03508884997,746,580,627,718.013786351984,2.36351323763865,1.24093294501057,{"v":1.50021221372179e-06,"d":"1.50E-06"},{"v":8.66448475095067e-05,"d":"8.66E-05"},"up","yes","PGP","protein_coding","chrNC_037352.1:1742545-1745400:-","gi|84000329|ref|NP_001033261.1|",1525,0,"phosphoglycolate phosphatase [Bos taurus]","gi|332801061|ref|NM_001038172.2|",2751,0,"Bos taurus phosphoglycolate phosphatase (PGP), mRNA","Q2T9S4",592,0,"Glycerol-3-phosphate phosphatase","SPBC15D4.15",159,{"v":4e-42,"d":"4.00E-42"},"COG0647","pfam13344","Hydrolase_6","Haloacid dehalogenase-like hydrolase. This family is part of the HAD superfamily.","GO:0016311|dephosphorylation;GO:0006114|glycerol biosynthetic process;GO:0006650|glycerophospholipid metabolic process;GO:0045721|negative regulation of gluconeogenesis;GO:0035335|peptidyl-tyrosine dephosphorylation;","GO:0005829|cytosol;","GO:0000121|glycerol-1-phosphatase activity;GO:0043136|glycerol-3-phosphatase activity;GO:0000287|magnesium ion binding;GO:0098519|nucleotide phosphatase activity, acting on free nucleotides;GO:0008967|phosphoglycolate phosphatase activity;GO:0004721|phosphoprotein phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;","K19269","PGP, PGLP; phosphoglycolate phosphatase [EC:3.1.3.18 3.1.3.48]"]
["gene29532",269,450,267,299.58208252527,119,138,146,147.824728966718,2.026603293098,1.01906370938055,0.00160439096420807,0.0262019911847856,"up","yes","ABCA3","protein_coding","chrNC_037352.1:1794636-1836056:-","gi|741973463|ref|XP_010817370.1|",8644,0,"PREDICTED: ATP-binding cassette sub-family A member 3 isoform X1 [Bos taurus]","gi|982966040|ref|XM_010819068.2|",6598,0,"PREDICTED: Bos taurus ATP binding cassette subfamily A member 3 (ABCA3), transcript variant X1, mRNA","Q99758",2962,0,"ATP-binding cassette sub-family A member 3","MA0868",176,{"v":2e-47,"d":"2.00E-47"},"COG1131","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0044267|cellular protein metabolic process;GO:0006869|lipid transport;GO:0042493|response to drug;GO:0051384|response to glucocorticoid;GO:0055085|transmembrane transport;","GO:0097208|alveolar lamellar body;GO:0097233|alveolar lamellar body membrane;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0097232|lamellar body membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0005319|lipid transporter activity;GO:0005215|transporter activity;","K05643","ABCA3; ATP-binding cassette, subfamily A (ABC1), member 3"]
["gene29557",263,191,261,211.296734388097,77,86,90,92.82863383812,2.27620213345559,1.18662867890344,0.000701646169777161,0.0138537486989012,"up","yes","PAQR4","protein_coding","chrNC_037352.1:2376836-2380362:+","gi|149642563|ref|NP_001092367.1|",1211,{"v":1e-159,"d":"1.00E-159"},"progestin and adipoQ receptor family member 4 [Bos taurus]","gi|149642562|ref|NM_001098897.1|",1975,0,"Bos taurus progestin and adipoQ receptor family member IV (PAQR4), mRNA","Q8N4S7",447,{"v":7e-152,"d":"7.00E-152"},"Progestin and adipoQ receptor family member 4",".",".",".",".","pfam03006","HlyIII","Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolizm. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene29641",20019,45647,41854,33031.0143340009,12878,12299,13615,14241.611452693,2.31933123886447,1.21370887541347,0.000314388529601979,0.00727479248830012,"up","yes","SRL","protein_coding","chrNC_037352.1:3395206-3432233:-","gi|528925612|ref|XP_005193064.1|",2428,0,"PREDICTED: sarcalumenin isoform X1 [Bos taurus]","gi|983006925|ref|XM_005193007.3|",4817,0,"PREDICTED: Bos taurus sarcalumenin (SRL), transcript variant X1, mRNA","Q86TD4",899,0,"Sarcalumenin",".",".",".",".","pfam00350","Dynamin_N","Dynamin family.",".","GO:0033018|sarcoplasmic reticulum lumen;","GO:0005525|GTP binding;",".","."]
["gene29666",415,372,361,340.940529684405,168,140,153,169.400150742929,2.01263415757991,1.00908495317723,0.00111109925483325,0.0196074068796908,"up","yes","ROGDI","protein_coding","chrNC_037352.1:3876449-3882213:-","gi|115495813|ref|NP_001068920.1|",1446,0,"protein rogdi homolog [Bos taurus]","gi|402743865|ref|NM_001075452.2|",1399,0,"Bos taurus rogdi homolog (ROGDI), mRNA","Q148F6",561,0,"Protein rogdi homolog",".",".",".",".","pfam10259","Rogdi_lz","Rogdi leucine zipper containing protein. This is a family of conserved proteins which have been suggested as containing leucine-zipper domains. A leucine zipper domain is a region of 30 amino acids with leucines repeating every seven or eight residues; these proteins do have many such leucines. The protein in Drosophila comes from the gene ROGDI.","GO:0007420|brain development;GO:0030097|hemopoiesis;GO:0022008|neurogenesis;GO:0042475|odontogenesis of dentin-containing tooth;GO:0008284|positive regulation of cell proliferation;","GO:0030424|axon;GO:0030054|cell junction;GO:0030425|dendrite;GO:0005635|nuclear envelope;GO:0043204|perikaryon;GO:0042734|presynaptic membrane;GO:0008021|synaptic vesicle;",".",".","."]
["gene29669",1344,2114,3215,2030.46885620065,1026,567,852,899.116913108868,2.25829236064519,1.17523227085374,0.00345849623117748,0.0458950492891743,"up","yes","PPL","protein_coding","chrNC_037352.1:3948018-3996446:-","gi|529006363|ref|XP_005224719.1|",7634,0,"PREDICTED: periplakin isoform X1 [Bos taurus]","gi|983006937|ref|XM_010799950.2|",6320,0,"PREDICTED: Bos taurus periplakin (PPL), transcript variant X1, mRNA","O60437",2478,0,"Periplakin",".",".",".",".","pfam13514","AAA_27","AAA domain. This domain is found in a number of double-strand DNA break proteins. This domain contains a P-loop motif.","GO:0070268|cornification;GO:0009612|response to mechanical stimulus;","GO:0001533|cornified envelope;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0030057|desmosome;GO:0070062|extracellular exosome;GO:0005739|mitochondrion;GO:0005634|nucleus;","GO:0045296|cadherin binding;GO:0005200|structural constituent of cytoskeleton;","K10386","PPL; periplakin"]
["gene29670",313,151,241,205.076756389482,63,49,73,67.8808014192171,3.02113045370475,1.59508848159961,{"v":8.67744417215186e-06,"d":"8.68E-06"},0.000383286598400304,"up","yes","SEC14L5","protein_coding","chrNC_037352.1:4014656-4054837:+","gi|594061799|ref|XP_006054971.1|",3754,0,"PREDICTED: SEC14-like protein 5 isoform X1 [Bubalus bubalis]","gi|741973717|ref|XM_005224579.2|",5155,0,"PREDICTED: Bos taurus SEC14 like lipid binding 5 (SEC14L5), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam04707","PRELI","PRELI-like family. This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.",".",".",".",".","."]
["gene29678",2727,3622,2816,2762.56752117904,984,1385,1164,1296.23802595188,2.13121931764837,1.09167906435608,{"v":1.21487748310585e-05,"d":"1.21E-05"},0.000505272149715642,"up","yes","RBFOX1","protein_coding","chrNC_037352.1:4206440-6640356:+","gi|742120434|ref|XP_010838750.1|",1894,0,"PREDICTED: RNA binding protein fox-1 homolog 1 isoform X7 [Bison bison bison]","gi|742120433|ref|XM_010840448.1|",3953,0,"PREDICTED: Bison bison bison RNA binding protein, fox-1 homolog (C. elegans) 1 (RBFOX1), transcript variant X7, mRNA","Q9NWB1",652,0,"RNA binding protein fox-1 homolog 1","TP0356",51.2,{"v":5e-06,"d":"5.00E-06"},"COG0724","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0006397|mRNA processing;GO:0007399|nervous system development;GO:0000381|regulation of alternative mRNA splicing, via spliceosome;GO:0008380|RNA splicing;GO:0050658|RNA transport;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0005802|trans-Golgi network;","GO:0003729|mRNA binding;GO:0008022|protein C-terminus binding;GO:0003723|RNA binding;","K14946","RBFOX, FOX; RNA binding protein fox-1"]
["gene29691",923,3241,1219,1677.06951727666,176,376,278,304.120972802572,5.51448162822158,2.46322527610809,{"v":6.9150220939318e-07,"d":"6.92E-07"},{"v":4.43353922161726e-05,"d":"4.43E-05"},"up","yes","ABAT","protein_coding","chrNC_037352.1:7551560-7641458:+","gi|296473436|tpg|DAA15551.1|",2708,0,"TPA: 4-aminobutyrate aminotransferase [Bos taurus]","gi|125991949|ref|NM_001081581.1|",4682,0,"Bos taurus 4-aminobutyrate aminotransferase (ABAT), mRNA","P80147",1013,0,"4-aminobutyrate aminotransferase, mitochondrial","SPAC19D5.07",411,{"v":1e-127,"d":"1.00E-127"},"COG0160","pfam00202","Aminotran_3","Aminotransferase class-III.","GO:0048148|behavioral response to cocaine;GO:0009450|gamma-aminobutyric acid catabolic process;GO:0042135|neurotransmitter catabolic process;","GO:0032144|4-aminobutyrate transaminase complex;GO:0005829|cytosol;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0047298|(S)-3-amino-2-methylpropionate transaminase activity;GO:0051537|2 iron, 2 sulfur cluster binding;GO:0034386|4-aminobutyrate:2-oxoglutarate transaminase activity;GO:0046872|metal ion binding;GO:0042803|protein homodimerization activity;GO:0030170|pyridoxal phosphate binding;GO:0032145|succinate-semialdehyde dehydrogenase binding;","K13524","ABAT; 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22]"]
["gene29709",2117,3763,3203,2768.65161168341,893,1520,1137,1302.02218357039,2.12642430107545,1.08842949714241,0.00221560056650896,0.0332177087562097,"up","yes","EMP2","protein_coding","chrNC_037352.1:9265460-9311084:-","gi|555954318|ref|XP_005889326.1|",767,{"v":7e-91,"d":"7.00E-91"},"PREDICTED: epithelial membrane protein 2 [Bos mutus]","gi|742167223|ref|XM_010850658.1|",3762,0,"PREDICTED: Bison bison bison epithelial membrane protein 2 (EMP2), mRNA","Q2NKU9",298,{"v":1e-91,"d":"1.00E-91"},"Epithelial membrane protein 2",".",".",".",".","pfam00822","PMP22_Claudin","PMP-22/EMP/MP20/Claudin family.","GO:0007015|actin filament organization;GO:0070252|actin-mediated cell contraction;GO:0032147|activation of protein kinase activity;GO:0032060|bleb assembly;GO:0043534|blood vessel endothelial cell migration;GO:0007155|cell adhesion;GO:0008219|cell death;GO:0016477|cell migration;GO:0007160|cell-matrix adhesion;GO:0045022|early endosome to late endosome transport;GO:0007566|embryo implantation;GO:0001765|membrane raft assembly;GO:0008284|positive regulation of cell proliferation;GO:0034394|protein localization to cell surface;GO:0072659|protein localization to plasma membrane;GO:0045765|regulation of angiogenesis;GO:0010594|regulation of endothelial cell migration;GO:0003093|regulation of glomerular filtration;GO:0043549|regulation of kinase activity;GO:2001212|regulation of vasculogenesis;GO:0001913|T cell mediated cytotoxicity;","GO:0045177|apical part of cell;GO:0016324|apical plasma membrane;GO:0009986|cell surface;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005794|Golgi apparatus;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0045121|membrane raft;GO:0005634|nucleus;GO:0005886|plasma membrane;",".",".","."]
["gene29718",9,10,36,16.6791647334835,1,3,1,1.83570368560646,9.08597877983407,3.18364193600615,0.00192355409432462,0.029924166774905,"up","yes","SOCS1","protein_coding","chrNC_037352.1:9912587-9914409:-","gi|76652907|ref|XP_869409.1|",891,{"v":1e-115,"d":"1.00E-115"},"PREDICTED: suppressor of cytokine signaling 1 [Bos taurus]","gi|983006977|ref|XM_864316.5|",1242,0,"PREDICTED: Bos taurus suppressor of cytokine signaling 1 (SOCS1), mRNA","O15524",336,{"v":1e-112,"d":"1.00E-112"},"Suppressor of cytokine signaling 1",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0019221|cytokine-mediated signaling pathway;GO:0038111|interleukin-7-mediated signaling pathway;GO:0035556|intracellular signal transduction;GO:0043377|negative regulation of CD8-positive, alpha-beta T cell differentiation;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0046426|negative regulation of JAK-STAT cascade;GO:0042532|negative regulation of tyrosine phosphorylation of STAT protein;GO:0043372|positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0045591|positive regulation of regulatory T cell differentiation;GO:0016567|protein ubiquitination;GO:0040008|regulation of growth;GO:0060334|regulation of interferon-gamma-mediated signaling pathway;GO:0001932|regulation of protein phosphorylation;","GO:0005737|cytoplasm;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0031410|cytoplasmic vesicle;GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0005159|insulin-like growth factor receptor binding;GO:0019210|kinase inhibitor activity;GO:0019901|protein kinase binding;GO:0004860|protein kinase inhibitor activity;","K04694","SOCS1, JAB; suppressor of cytokine signaling 1"]
["gene29721",0,23,1,7.84462825535971,0,0,0,0,"Inf","Inf",0.00242792992709014,0.0353156320110753,"up","yes","PRM2","protein_coding","chrNC_037352.1:9933488-9934665:-","gi|742167257|ref|XP_010848970.1|",169,{"v":3e-12,"d":"3.00E-12"},"PREDICTED: protamine-2 [Bison bison bison]","gi|402745711|ref|NM_174157.4|",537,0,"Bos taurus protamine 2 (PRM2), mRNA",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["gene29722",0,275,4,91.3508483162451,0,0,0,0,"Inf","Inf",{"v":3.28606002481819e-21,"d":"3.29E-21"},{"v":2.60429384911355e-18,"d":"2.60E-18"},"up","yes","PRM1","protein_coding","chrNC_037352.1:9936642-9937121:-","gi|926723490|ref|XP_013830076.1|",143,{"v":2e-09,"d":"2.00E-09"},"PREDICTED: sperm protamine P1 [Capra hircus]","gi|742167260|ref|XR_826186.1|",376,0,"PREDICTED: Bison bison bison uncharacterized LOC104996417 (LOC104996417), ncRNA",".",".",".",".",".",".",".",".","pfam00260","Protamine_P1","Protamine P1.",".",".",".",".","."]
["gene29773",3218,1308,2983,2183.48413359412,594,697,677,722.187226638308,3.02343222512805,1.59618723912918,{"v":1.03382386147128e-10,"d":"1.03E-10"},{"v":1.68548734809354e-08,"d":"1.69E-08"},"up","yes","MYH11","protein_coding","chrNC_037352.1:14124960-14252447:-","gi|594051605|ref|XP_006050134.1|",8994,0,"PREDICTED: myosin-11 isoform X1 [Bubalus bubalis]","gi|742118107|ref|XM_010839894.1|",6428,0,"PREDICTED: Bison bison bison myosin, heavy chain 11, smooth muscle (MYH11), transcript variant X2, mRNA","P35749",3349,0,"Myosin-11","SPCC645.05c",778,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0048739|cardiac muscle fiber development;GO:0048251|elastic fiber assembly;GO:0007018|microtubule-based movement;GO:0006936|muscle contraction;GO:0030241|skeletal muscle myosin thick filament assembly;GO:0006939|smooth muscle contraction;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0042470|melanosome;GO:0005859|muscle myosin complex;GO:0032982|myosin filament;","GO:0051015|actin filament binding;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0008307|structural constituent of muscle;","K10352","MYH; myosin heavy chain"]
["gene29843",11299,16526,16283,13361.5058796212,4515,7068,5357,6215.16282824616,2.1498239465098,1.10421851939757,0.000411823675438289,0.00905916829909778,"up","yes","EEF2K","protein_coding","chrNC_037352.1:19884886-19957077:+","gi|300796175|ref|NP_001179471.1|",3784,0,"eukaryotic elongation factor 2 kinase [Bos taurus]","gi|982966714|ref|XM_005224739.3|",5563,0,"PREDICTED: Bos taurus eukaryotic elongation factor 2 kinase (EEF2K), transcript variant X1, mRNA","O00418",1308,0,"Eukaryotic elongation factor 2 kinase",".",".",".",".","pfam02816","Alpha_kinase","Alpha-kinase family. This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.","GO:0071454|cellular response to anoxia;GO:1990416|cellular response to brain-derived neurotrophic factor stimulus;GO:0071277|cellular response to calcium ion;GO:0071320|cellular response to cAMP;GO:0032869|cellular response to insulin stimulus;GO:0043066|negative regulation of apoptotic process;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:0045807|positive regulation of endocytosis;GO:0051965|positive regulation of synapse assembly;GO:0046777|protein autophosphorylation;GO:0031952|regulation of protein autophosphorylation;GO:0002931|response to ischemia;GO:1990637|response to prolactin;GO:0006414|translational elongation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043197|dendritic spine;GO:0014069|postsynaptic density;","GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0005516|calmodulin binding;GO:0004686|elongation factor-2 kinase activity;GO:0004672|protein kinase activity;GO:0008135|translation factor activity, RNA binding;","K08292","EEF2K; elongation factor 2 kinase [EC:2.7.11.20]"]
["gene29868",227,145,181,162.269553929842,52,76,69,72.2341252360854,2.24643897049338,1.16763986837703,0.00189951963930098,0.0296148605622384,"up","yes","PLK1","protein_coding","chrNC_037352.1:21334524-21345063:+","gi|363548454|sp|Q2TA25.2|PLK1_BOVIN",2770,0,"RecName: Full=Serine/threonine-protein kinase PLK1; AltName: Full=Polo-like kinase 1; Short=PLK-1","gi|402766851|ref|NM_001038173.2|",2167,0,"Bos taurus polo like kinase 1 (PLK1), mRNA","Q2TA25",1071,0,"Serine/threonine-protein kinase PLK1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0007098|centrosome cycle;GO:0045184|establishment of protein localization;GO:0016321|female meiosis chromosome segregation;GO:0000086|G2/M transition of mitotic cell cycle;GO:0045143|homologous chromosome segregation;GO:0001578|microtubule bundle formation;GO:0000278|mitotic cell cycle;GO:0000281|mitotic cytokinesis;GO:0000070|mitotic sister chromatid segregation;GO:0007094|mitotic spindle assembly checkpoint;GO:0043066|negative regulation of apoptotic process;GO:0045736|negative regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0051081|nuclear envelope disassembly;GO:0018105|peptidyl-serine phosphorylation;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1904668|positive regulation of ubiquitin protein ligase activity;GO:0051443|positive regulation of ubiquitin-protein transferase activity;GO:0031648|protein destabilization;GO:0071168|protein localization to chromatin;GO:0090435|protein localization to nuclear envelope;GO:0006468|protein phosphorylation;GO:0016567|protein ubiquitination;GO:0032465|regulation of cytokinesis;GO:1901673|regulation of mitotic spindle assembly;GO:0043393|regulation of protein binding;GO:0072425|signal transduction involved in G2 DNA damage checkpoint;GO:0070194|synaptonemal complex disassembly;","GO:0005813|centrosome;GO:0000785|chromatin;GO:0000942|condensed nuclear chromosome outer kinetochore;GO:0005737|cytoplasm;GO:0000776|kinetochore;GO:0030496|midbody;GO:0005634|nucleus;GO:0005819|spindle;GO:0005876|spindle microtubule;GO:0051233|spindle midzone;GO:0000922|spindle pole;GO:0000795|synaptonemal complex;","GO:0010997|anaphase-promoting complex binding;GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0000287|magnesium ion binding;GO:0008017|microtubule binding;GO:0019901|protein kinase binding;GO:0004674|protein serine/threonine kinase activity;","K06631","PLK1; polo-like kinase 1 [EC:2.7.11.21]"]
["gene29893",0,99,0,32.4440502414526,0,0,0,0,"Inf","Inf",{"v":1.7152149284945e-09,"d":"1.72E-09"},{"v":2.14196429708644e-07,"d":"2.14E-07"},"up","yes","C25H16orf82","protein_coding","chrNC_037352.1:24671805-24673861:+","gi|942070329|ref|XP_014335371.1|",866,{"v":5e-108,"d":"5.00E-108"},"PREDICTED: protein TNT [Bos mutus]","gi|485464568|ref|NM_001145758.2|",2057,0,"Bos taurus chromosome 25 open reading frame, human C16orf82 (C25H16orf82), mRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["gene29913",115690,621444,318289,331563.125345932,48150,79159,63276,69888.2230058049,4.74419166900827,2.24616229705546,0.000936020100433266,0.017151952142236,"up","yes","ATP2A1","protein_coding","chrNC_037352.1:25929251-25946618:-","gi|115495087|ref|NP_001069235.1|",5010,0,"sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [Bos taurus]","gi|115495086|ref|NM_001075767.1|",3491,0,"Bos taurus ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (ATP2A1), mRNA","Q0VCY0",1904,0,"Sarcoplasmic/endoplasmic reticulum calcium ATPase 1","BH2515",509,{"v":2e-161,"d":"2.00E-161"},"COG0474","pfam00122","E1-E2_ATPase","E1-E2 ATPase.",".","GO:0016021|integral component of membrane;GO:0033017|sarcoplasmic reticulum membrane;","GO:0005524|ATP binding;GO:0005388|calcium-transporting ATPase activity;GO:0046872|metal ion binding;","K05853","ATP2A; Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum [EC:3.6.3.8]"]
["gene29954",128,249,443,251.016360125865,72,32,65,62.1181424504346,4.04095084340547,2.01469480180434,{"v":8.17125485582586e-05,"d":"8.17E-05"},0.00245922017185198,"up","yes","KIF22","protein_coding","chrNC_037352.1:26438465-26453268:-","gi|556735114|ref|XP_005963177.1|",2986,0,"PREDICTED: kinesin-like protein KIF22 [Pantholops hodgsonii]","gi|346644821|ref|NM_001101868.2|",2085,0,"Bos taurus kinesin family member 22 (KIF22), mRNA","A6QPL4",1144,0,"Kinesin-like protein KIF22","ECU11g2020",223,{"v":8e-63,"d":"8.00E-63"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0006281|DNA repair;GO:0051310|metaphase plate congression;GO:0007018|microtubule-based movement;GO:0007080|mitotic metaphase plate congression;GO:0007062|sister chromatid cohesion;","GO:0000785|chromatin;GO:0005829|cytosol;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0072686|mitotic spindle;GO:0016607|nuclear speck;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0003677|DNA binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10403","KIF22; kinesin family member 22"]
["gene29965",91700,442786,474257,314662.535713128,26262,92832,53175,63078.8209323646,4.98840230464232,2.31857782032147,0.00334205688435819,0.0447663028017012,"up","yes","MYLPF","protein_coding","chrNC_037352.1:26559395-26561857:+","gi|562838033|ref|XP_006148229.1|",877,{"v":4e-117,"d":"4.00E-117"},"PREDICTED: myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [Tupaia chinensis]","gi|115497165|ref|NM_001075647.1|",645,0,"Bos taurus myosin light chain, phosphorylatable, fast skeletal muscle (MYLPF), mRNA","Q0P571",327,{"v":9e-113,"d":"9.00E-113"},"Myosin regulatory light chain 2, skeletal muscle isoform","ECU03g1570",84.3,{"v":3e-19,"d":"3.00E-19"},"COG5126","pfam13405","EF-hand_6","EF-hand domain.","GO:0007519|skeletal muscle tissue development;","GO:0016459|myosin complex;","GO:0005509|calcium ion binding;GO:0008307|structural constituent of muscle;","K12758","MYLPF; fast skeletal myosin light chain 2"]
["gene30059",467,473,660,479.421792048576,41,58,51,55.0193880100833,8.71368819952547,3.12328349045684,{"v":2.77221747599479e-23,"d":"2.77E-23"},{"v":3.29558903365031e-20,"d":"3.30E-20"},"up","yes","GALNT17","protein_coding","chrNC_037352.1:29133705-29563785:-","gi|300796919|ref|NP_001178996.1|",3042,0,"putative polypeptide N-acetylgalactosaminyltransferase-like protein 3 [Bos taurus]","gi|433660820|ref|NM_001192067.2|",3609,0,"Bos taurus Williams-Beuren syndrome chromosome region 17 (WBSCR17), mRNA","Q6IS24",1137,0,"Polypeptide N-acetylgalactosaminyltransferase 17",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0006486|protein glycosylation;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["gene30070",21887,60860,32282,35563.6593172841,14468,15351,16163,16875.7076964216,2.10738772897951,1.07545577367793,0.00242400189152001,0.0353096323186114,"up","yes","CASTOR2","protein_coding","chrNC_037352.1:32610702-32665116:+","gi|297490469|ref|XP_002698225.1|",1683,0,"PREDICTED: GATS-like protein 2 [Bos taurus]","gi|983007384|ref|XM_602920.8|",6654,0,"PREDICTED: Bos taurus GATS protein-like 2 (GATSL2), mRNA","A6NHX0",644,0,"Cytosolic arginine sensor for mTORC1 subunit 2","MA2818",50.8,{"v":5e-06,"d":"5.00E-06"},"COG3603","pfam13840","ACT_7","ACT domain. The ACT domain is a structural motif of 70-90 amino acids that functions in the control of metabolizm, solute transport and signal transduction. They are thus found in a variety of different proteins in a variety of different arrangements. In mammalian phenylalanine hydroxylase the domain forms no contacts but promotes an allosteric effect despite the apparent lack of ligand binding.","GO:1904262|negative regulation of TORC1 signaling;","GO:0005829|cytosol;","GO:0042802|identical protein binding;",".","."]
["gene30140",811,1086,805,814.499759747048,286,390,381,387.553496199445,2.10164472191443,1.07151880571631,{"v":6.35827117611672e-05,"d":"6.36E-05"},0.00198694233215538,"up","yes","LOC521224","protein_coding","chrNC_037352.1:34553966-34572242:+","gi|555961566|ref|XP_005892877.1|",4032,0,"PREDICTED: ras GTPase-activating protein 4 isoform X1 [Bos mutus]","gi|983007408|ref|XM_003584050.4|",2852,0,"PREDICTED: Bos taurus ras GTPase-activating protein 4 (LOC521224), transcript variant X1, mRNA","O43374",1397,0,"Ras GTPase-activating protein 4",".",".",".",".","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0071277|cellular response to calcium ion;GO:0000165|MAPK cascade;GO:0034260|negative regulation of GTPase activity;GO:0046580|negative regulation of Ras protein signal transduction;","GO:0005829|cytosol;GO:0031235|intrinsic component of the cytoplasmic side of the plasma membrane;","GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;GO:0005543|phospholipid binding;","K17630","RASA4, CAPRI; Ras GTPase-activating protein 4"]
["gene30181",52,319,28,126.693753723413,25,33,28,31.5620329079645,4.01411892867783,2.00508336091378,{"v":7.77313131951316e-06,"d":"7.77E-06"},0.000348703159869544,"up","yes","ACHE","protein_coding","chrNC_037352.1:35763106-35768960:+","gi|982967423|ref|XP_015315975.1|",2845,0,"PREDICTED: acetylcholinesterase isoform X1 [Bos taurus]","gi|982967422|ref|XM_015460489.1|",3860,0,"PREDICTED: Bos taurus acetylcholinesterase (Yt blood group) (ACHE), transcript variant X1, mRNA","P23795",985,0,"Acetylcholinesterase","BS_pnbA",224,{"v":7e-62,"d":"7.00E-62"},"COG2272","pfam00135","COesterase","Carboxylesterase family.","GO:0042135|neurotransmitter catabolic process;","GO:0031225|anchored component of membrane;GO:0030054|cell junction;GO:0005576|extracellular region;GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0003990|acetylcholinesterase activity;GO:0001540|beta-amyloid binding;GO:0052689|carboxylic ester hydrolase activity;","K01049","ACHE; acetylcholinesterase [EC:3.1.1.7]"]
["gene30217",16,54,0,21.8667264665353,2,5,1,2.94344691377023,7.42895221389484,2.89315874610518,0.00145496390007537,0.0243042008390224,"up","yes","STAG3","protein_coding","chrNC_037352.1:36204771-36238958:-","gi|982967305|ref|XP_015315934.1|",6307,0,"PREDICTED: cohesin subunit SA-3 isoform X1 [Bos taurus]","gi|982967316|ref|XM_010819543.2|",4583,0,"PREDICTED: Bos taurus stromal antigen 3 (STAG3), transcript variant X7, mRNA","Q9UJ98",1853,0,"Cohesin subunit SA-3","SPAC17H9.20",150,{"v":2e-36,"d":"2.00E-36"},"COG5537","pfam08514","STAG","STAG domain. STAG domain proteins are subunits of cohesin complex - a protein complex required for sister chromatid cohesion in eukaryotes. The STAG domain is present in Schizosaccharomyces pombe mitotic cohesin Psc3, and the meiosis specific cohesin Rec11. Many organisms express a meiosis-specific STAG protein, for example, mice and humans have a meiosis specific variant called STAG3, although budding yeast does not have a meiosis specific version.","GO:0007130|synaptonemal complex assembly;","GO:0000775|chromosome, centromeric region;GO:0005615|extracellular space;GO:0030893|meiotic cohesin complex;GO:0005634|nucleus;GO:0000795|synaptonemal complex;",".","K13055","STAG3; cohesin complex subunit SA-3"]
["gene30222",14,5,11,8.66565168142904,0,0,0,0,"Inf","Inf",0.00111255434037636,0.0196173596244692,"up","yes","LOC101903891","protein_coding","chrNC_037352.1:36267294-36283641:+","gi|741902490|ref|XP_010798716.1|",2775,0,"PREDICTED: NXPE family member 3-like [Bos taurus]","gi|983007288|ref|XM_010800414.2|",1955,0,"PREDICTED: Bos taurus NXPE family member 3-like (LOC101903891), mRNA","Q08BN9",291,{"v":9e-87,"d":"9.00E-87"},"NXPE family member 3",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".","GO:0005576|extracellular region;",".",".","."]
["gene30373",231,56,156,126.467132587598,42,26,38,38.9569063427139,3.24633407681385,1.69881147374978,{"v":4.32302548999192e-05,"d":"4.32E-05"},0.00142036241547423,"up","yes","MICALL2","protein_coding","chrNC_037352.1:41461259-41480270:+","gi|296472932|tpg|DAA15047.1|",3346,0,"TPA: MICAL-like 2 [Bos taurus]","gi|149642832|ref|NM_001098932.1|",2938,0,"Bos taurus MICAL-like 2 (MICALL2), mRNA","Q8IY33",685,0,"MICAL-like protein 2","ECU09g0290",109,{"v":7e-24,"d":"7.00E-24"},"COG5069","pfam12130","DUF3585","Protein of unknown function (DUF3585). This domain is found in eukaryotes. This domain is typically between 135 and 149 amino acids in length and is found associated with pfam00307.","GO:0031532|actin cytoskeleton reorganization;GO:0030041|actin filament polymerization;GO:0070830|bicellular tight junction assembly;GO:0032456|endocytic recycling;GO:0031175|neuron projection development;GO:1903955|positive regulation of protein targeting to mitochondrion;GO:0034446|substrate adhesion-dependent cell spreading;","GO:0005923|bicellular tight junction;GO:0005911|cell-cell junction;GO:0005829|cytosol;GO:0043005|neuron projection;GO:0005886|plasma membrane;GO:0055037|recycling endosome;GO:0001725|stress fiber;","GO:0051015|actin filament binding;GO:0042805|actinin binding;GO:0031005|filamin binding;GO:0046872|metal ion binding;GO:0017137|Rab GTPase binding;",".","."]
["gene30390",4088,4795,3382,3675.51942884464,1434,1873,1466,1752.53741251481,2.0972559002723,1.06850290508231,{"v":1.97229885210906e-05,"d":"1.97E-05"},0.000753301988614775,"up","yes","SUN1","protein_coding","chrNC_037352.1:41819878-41866794:-","gi|803256022|ref|XP_011987967.1|",3804,0,"PREDICTED: SUN domain-containing protein 1 isoform X2 [Ovis aries musimon]","gi|983007564|ref|XM_010806360.2|",3041,0,"PREDICTED: Bos taurus SUN domain-containing protein 1 (LOC100847692), transcript variant X1, mRNA","Q9D666",979,0,"SUN domain-containing protein 1",".",".",".",".","pfam07738","Sad1_UNC","Sad1 / UNC-like C-terminal. The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.","GO:0051642|centrosome localization;GO:0090286|cytoskeletal anchoring at nuclear membrane;GO:0070197|meiotic attachment of telomere to nuclear envelope;GO:0006998|nuclear envelope organization;GO:0090292|nuclear matrix anchoring at nuclear membrane;GO:0021817|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration;GO:0001503|ossification;GO:0009612|response to mechanical stimulus;GO:0007283|spermatogenesis;GO:0007129|synapsis;","GO:0002080|acrosomal membrane;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005639|integral component of nuclear inner membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0034993|LINC complex;GO:0005635|nuclear envelope;GO:0031965|nuclear membrane;GO:0005634|nucleus;GO:0002081|outer acrosomal membrane;","GO:0005521|lamin binding;GO:0043495|protein anchor;","K19347","SUN1_2; SUN domain-containing protein 1/2"]
["gene30400",54,53,25,39.1207326273073,1,1,1,1.10172854762757,35.50850407893,5.15009267790554,{"v":6.88530566823437e-09,"d":"6.89E-09"},{"v":7.41300588756206e-07,"d":"7.41E-07"},"up","yes","LOC516442","protein_coding","chrNC_037352.1:42246498-42262447:-","gi|76654443|ref|XP_594595.2|",4591,0,"PREDICTED: patched domain-containing protein 3 [Bos taurus]","gi|983007358|ref|XM_594595.5|",4718,0,"PREDICTED: Bos taurus patched domain-containing protein 3 (LOC516442), mRNA","Q0EEE2",1262,0,"Patched domain-containing protein 3",".",".",".",".","pfam02460","Patched","Patched family. The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.",".","GO:0016021|integral component of membrane;GO:0097225|sperm midpiece;",".",".","."]
["gene30401",98,22,12,36.436325755791,3,0,4,2.56519582436762,14.2041108166755,3.82823661592383,{"v":9.68018459318286e-05,"d":"9.68E-05"},0.0028268715110348,"up","yes","LOC112444314","pseudogene","chrNC_037352.1:42267610-42293728:-","gi|426246109|ref|XP_004016840.1|",797,{"v":3e-121,"d":"3.00E-121"},"PREDICTED: olfactory receptor 1038-like [Ovis aries]","gi|548496871|ref|XM_005690273.1|",695,0,"PREDICTED: Capra hircus olfactory receptor 1038-like (LOC102190056), mRNA","Q8VGS1",251,{"v":2e-88,"d":"2.00E-88"},"Olfactory receptor 1038",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007186|G-protein coupled receptor signaling pathway;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;GO:0005549|odorant binding;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["gene30423",936,485,486,552.147538027428,168,263,219,238.363832366544,2.31640653091347,1.21188846950342,{"v":2.6442984609809e-05,"d":"2.64E-05"},0.00094898716214146,"up","yes","CISD1","protein_coding","chrNC_037353.1:745914-764106:-","gi|529008075|ref|XP_005225399.1|",607,{"v":1e-75,"d":"1.00E-75"},"PREDICTED: CDGSH iron-sulfur domain-containing protein 1 isoform X1 [Bos taurus]","gi|942054670|ref|XM_014478237.1|",857,0,"PREDICTED: Bos mutus CDGSH iron sulfur domain 1 (CISD1), transcript variant X3, mRNA","Q3ZBU2",172,{"v":6e-52,"d":"6.00E-52"},"CDGSH iron-sulfur domain-containing protein 1",".",".",".",".","pfam09360","zf-CDGSH","Iron-binding zinc finger CDGSH type. The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.","GO:0043457|regulation of cellular respiration;","GO:0016021|integral component of membrane;GO:0005741|mitochondrial outer membrane;","GO:0051537|2 iron, 2 sulfur cluster binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;",".","."]
["gene30430",162,139,172,140.598642757776,18,16,13,17.2922742770512,8.1307201415586,3.02338313811138,{"v":9.81669837214556e-12,"d":"9.82E-12"},{"v":1.96176416608662e-09,"d":"1.96E-09"},"up","yes","ZWINT","protein_coding","chrNC_037353.1:2809079-2813939:+","gi|742188746|ref|XP_010854870.1|",1240,{"v":1e-165,"d":"1.00E-165"},"PREDICTED: ZW10 interactor isoform X2 [Bison bison bison]","gi|402746854|ref|NM_001040529.2|",1559,0,"Bos taurus ZW10 interacting kinetochore protein (ZWINT), mRNA","Q2TBH8",479,{"v":4e-166,"d":"4.00E-166"},"ZW10 interactor",".",".",".",".","pfam15556","Zwint","ZW10 interactor. This family of proteins is found in eukaryotes. Proteins in this family are typically between 127 and 281 amino acids in length.","GO:0051301|cell division;GO:0007093|mitotic cell cycle checkpoint;","GO:0000777|condensed chromosome kinetochore;GO:0005634|nucleus;",".",".","."]
["gene30545",940,977,925,849.253526298373,387,343,387,410.221494896334,2.07023165988165,1.0497922150011,{"v":7.32396013791384e-05,"d":"7.32E-05"},0.00223965602030889,"up","yes","PLCE1","protein_coding","chrNC_037353.1:15469839-15846884:+","gi|329663494|ref|NP_001192781.1|",11710,0,"1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 [Bos taurus]","gi|982968117|ref|XM_005225543.3|",8568,0,"PREDICTED: Bos taurus phospholipase C epsilon 1 (PLCE1), transcript variant X1, mRNA","Q9P212",3928,0,"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1",".",".",".",".","pfam00388","PI-PLC-X","Phosphatidylinositol-specific phospholipase C, X domain. This associates with pfam00387 to form a single structural unit.","GO:0000187|activation of MAPK activity;GO:0019722|calcium-mediated signaling;GO:0008283|cell proliferation;GO:0007010|cytoskeleton organization;GO:0006651|diacylglycerol biosynthetic process;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0032835|glomerulus development;GO:0007507|heart development;GO:0043647|inositol phosphate metabolic process;GO:0048016|inositol phosphate-mediated signaling;GO:0016042|lipid catabolic process;GO:0007200|phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0007265|Ras protein signal transduction;GO:0001558|regulation of cell growth;GO:0008277|regulation of G-protein coupled receptor protein signaling pathway;GO:0045859|regulation of protein kinase activity;GO:0046578|regulation of Ras protein signal transduction;GO:0006940|regulation of smooth muscle contraction;","GO:0005829|cytosol;GO:0000139|Golgi membrane;GO:0005886|plasma membrane;","GO:0019899|enzyme binding;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0046872|metal ion binding;GO:0004435|phosphatidylinositol phospholipase C activity;GO:0004629|phospholipase C activity;GO:0017016|Ras GTPase binding;","K05860","PLCE; phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]"]
["gene3061",43,36,25,30.6826764755969,6,9,5,7.35036110428051,4.17430872310868,2.06153730313965,0.00382926294189891,0.0491907703715974,"up","yes","LOC782367","protein_coding","chrNC_037330.1:12022969-12026538:-","gi|296489784|tpg|DAA31897.1|",1967,0,"TPA: CD1D antigen, d polypeptide-like [Bos taurus]","gi|982978245|ref|XM_005200006.3|",1722,0,"PREDICTED: Bos taurus antigen-presenting glycoprotein CD1d (LOC782367), mRNA","O62848",503,{"v":3e-174,"d":"3.00E-174"},"Antigen-presenting glycoprotein CD1d",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.","GO:0045087|innate immune response;","GO:0016323|basolateral plasma membrane;GO:0005789|endoplasmic reticulum membrane;GO:0010008|endosome membrane;GO:0016021|integral component of membrane;GO:0005765|lysosomal membrane;",".","K06448","CD1; CD1 antigen"]
["gene30654",3017,10570,9692,7226.89904767825,2821,3385,3037,3392.92736567332,2.12998931860248,1.09084619569155,{"v":7.11338628213687e-05,"d":"7.11E-05"},0.00218698301740999,"up","yes","HIF1AN","protein_coding","chrNC_037353.1:21422732-21431815:+","gi|594058184|ref|XP_006053258.1|",1756,0,"PREDICTED: hypoxia-inducible factor 1-alpha inhibitor [Bubalus bubalis]","gi|402693018|ref|NM_001083443.2|",1331,0,"Bos taurus hypoxia inducible factor 1, alpha subunit inhibitor (HIF1AN), mRNA","Q9NWT6",676,0,"Hypoxia-inducible factor 1-alpha inhibitor",".",".",".",".","pfam13621","Cupin_8","Cupin-like domain. This cupin like domain shares similarity to the JmjC domain.","GO:0045746|negative regulation of Notch signaling pathway;GO:0061428|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0055114|oxidation-reduction process;GO:0042265|peptidyl-asparagine hydroxylation;GO:0042264|peptidyl-aspartic acid hydroxylation;GO:0036138|peptidyl-histidine hydroxylation;GO:0045663|positive regulation of myoblast differentiation;GO:2001214|positive regulation of vasculogenesis;GO:0061418|regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0048471|perinuclear region of cytoplasm;","GO:0071532|ankyrin repeat binding;GO:0031406|carboxylic acid binding;GO:0048037|cofactor binding;GO:0005506|iron ion binding;GO:0051059|NF-kappaB binding;GO:0005112|Notch binding;GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0019826|oxygen sensor activity;GO:0036140|peptidyl-asparagine 3-dioxygenase activity;GO:0036139|peptidyl-histidine dioxygenase activity;GO:0042803|protein homodimerization activity;GO:0008270|zinc ion binding;","K18055","HIF1AN; hypoxia-inducible factor 1-alpha inhibitor (HIF hydroxylase) [EC:1.14.11.30]"]
["gene30707",2560,2065,1217,1717.69952196337,614,662,640,703.462026654606,2.4417800206389,1.28793323413837,{"v":1.97468341707274e-07,"d":"1.97E-07"},{"v":1.4904680574736e-05,"d":"1.49E-05"},"up","yes","WBP1L","protein_coding","chrNC_037353.1:23347608-23406167:+","gi|529008895|ref|XP_005225747.1|",1601,0,"PREDICTED: WW domain binding protein 1-like isoform X2 [Bos taurus]","gi|983007896|ref|XM_015469590.1|",4179,0,"PREDICTED: Bos taurus WW domain binding protein 1-like (WBP1L), transcript variant X2, mRNA","Q9NX94",554,0,"WW domain binding protein 1-like",".",".",".",".","pfam11669","WBP-1","WW domain-binding protein 1. This family of proteins represents WBP-1, a ligand of the WW domain of Yes-associated protein. This protein has a proline-rich domain. WBP-1 does not bind to the SH3 domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene30721",3891,1721,3585,2679.11819692929,1251,1022,1269,1300.71977177567,2.05971974522376,1.0424480511553,{"v":2.25345072952005e-05,"d":"2.25E-05"},0.000839336850704131,"up","yes","ATP5MD","protein_coding","chrNC_037353.1:23982412-23987702:-","gi|431895474|gb|ELK04990.1|",311,{"v":3e-34,"d":"3.00E-34"},"Up-regulated during skeletal muscle growth protein 5 [Pteropus alecto]","gi|555951811|ref|XM_005888039.1|",354,0,"PREDICTED: Bos mutus up-regulated during skeletal muscle growth 5 homolog (mouse) (USMG5), transcript variant X1, mRNA","Q3ZBI7",121,{"v":4e-35,"d":"4.00E-35"},"Up-regulated during skeletal muscle growth protein 5",".",".",".",".","pfam14960","ATP_synth_reg","ATP synthase regulation. Members of this family are subunits of mitochondrial ATP synthase (F-ATPase) and vacuolar ATPase (V-ATPase). In F-ATPase, this subunit regulates mitochondrial ATP synthase population.",".","GO:0016021|integral component of membrane;GO:0005753|mitochondrial proton-transporting ATP synthase complex;",".","K18194","USMG5, DAPIT; up-regulated during skeletal muscle growth protein 5"]
["gene30729",2667,7837,6476,5252.3253238303,1145,1460,1437,1482.48435469359,3.54292125053548,1.8249393986415,{"v":1.62208130745315e-12,"d":"1.62E-12"},{"v":3.92200015109709e-10,"d":"3.92E-10"},"up","yes","NEURL1","protein_coding","chrNC_037353.1:24086083-24160153:+","gi|529008428|ref|XP_005225553.1|",2749,0,"PREDICTED: E3 ubiquitin-protein ligase NEURL1 isoform X1 [Bos taurus]","gi|982968053|ref|XM_005225496.3|",3887,0,"PREDICTED: Bos taurus neuralized E3 ubiquitin protein ligase 1 (NEURL1), transcript variant X1, mRNA","O76050",1001,0,"E3 ubiquitin-protein ligase NEURL1",".",".",".",".","pfam07177","Neuralized","Neuralized. This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.","GO:0007420|brain development;GO:0071230|cellular response to amino acid stimulus;GO:0007595|lactation;GO:0008285|negative regulation of cell proliferation;GO:0045746|negative regulation of Notch signaling pathway;GO:0007399|nervous system development;GO:0007219|Notch signaling pathway;GO:0043065|positive regulation of apoptotic process;GO:0060999|positive regulation of dendritic spine development;GO:0045741|positive regulation of epidermal growth factor-activated receptor activity;GO:0051491|positive regulation of filopodium assembly;GO:0048170|positive regulation of long-term neuronal synaptic plasticity;GO:0090129|positive regulation of synapse maturation;GO:0006513|protein monoubiquitination;GO:0007519|skeletal muscle tissue development;GO:0007288|sperm axoneme assembly;","GO:0097440|apical dendrite;GO:0030054|cell junction;GO:0043197|dendritic spine;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;","GO:0046872|metal ion binding;GO:0045183|translation factor activity, non-nucleic acid binding;GO:0061630|ubiquitin protein ligase activity;GO:0004842|ubiquitin-protein transferase activity;","K01931","NEUR; protein neuralized [EC:2.3.2.27]"]
["gene30828",976,1319,699,901.3059199177,105,171,142,153.258673926968,5.88094557275888,2.5560481386423,{"v":5.40604682777217e-17,"d":"5.41E-17"},{"v":2.56254456691844e-14,"d":"2.56E-14"},"up","yes","GFRA1","protein_coding","chrNC_037353.1:36464988-36696498:-","gi|741976452|ref|XP_010818342.1|",2243,0,"PREDICTED: GDNF family receptor alpha-1 isoform X1 [Bos taurus]","gi|982968455|ref|XM_010820041.2|",3845,0,"PREDICTED: Bos taurus GDNF family receptor alpha 1 (GFRA1), transcript variant X2, mRNA","P97785",840,0,"GDNF family receptor alpha-1",".",".",".",".","pfam02351","GDNF","GDNF/GAS1 domain. This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.","GO:0009653|anatomical structure morphogenesis;GO:0016477|cell migration;GO:0007399|nervous system development;GO:0030182|neuron differentiation;GO:0031175|neuron projection development;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;","GO:0031225|anchored component of membrane;GO:0030424|axon;GO:0009897|external side of plasma membrane;GO:0005615|extracellular space;GO:0019898|extrinsic component of membrane;GO:0043025|neuronal cell body;GO:0098797|plasma membrane protein complex;GO:0043235|receptor complex;","GO:0005178|integrin binding;GO:0005030|neurotrophin receptor activity;GO:0038023|signaling receptor activity;",".","."]
["gene30866",1641,551,605,794.063761223957,286,326,317,340.964026923113,2.32887841098561,1.219635319477,{"v":9.23605343480172e-06,"d":"9.24E-06"},0.000403543400533427,"up","yes","GRK5","protein_coding","chrNC_037353.1:39360219-39591954:+","gi|741976617|ref|XP_010818379.1|",2702,0,"PREDICTED: G protein-coupled receptor kinase 5 isoform X1 [Bos taurus]","gi|742199720|ref|XR_826986.1|",4306,0,"PREDICTED: Bison bison bison uncharacterized LOC105002566 (LOC105002566), ncRNA","P43249",1028,0,"G protein-coupled receptor kinase 5",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0006915|apoptotic process;GO:0045444|fat cell differentiation;GO:0043066|negative regulation of apoptotic process;GO:0008284|positive regulation of cell proliferation;GO:0046777|protein autophosphorylation;GO:0051726|regulation of cell cycle;GO:0007217|tachykinin receptor signaling pathway;GO:0016055|Wnt signaling pathway;","GO:0005829|cytosol;GO:0031965|nuclear membrane;GO:0016607|nuclear speck;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0047696|beta-adrenergic receptor kinase activity;GO:0004703|G-protein coupled receptor kinase activity;GO:0008289|lipid binding;GO:0004674|protein serine/threonine kinase activity;","K08291","GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]"]
["gene30892",3867,4544,5336,4135.78022809321,1012,1479,1125,1327.12242131239,3.11635171079646,1.63985806484619,{"v":1.52587075063532e-09,"d":"1.53E-09"},{"v":1.96101884623317e-07,"d":"1.96E-07"},"up","yes","HTRA1","protein_coding","chrNC_037353.1:42285637-42343167:+","gi|803207009|ref|XP_011964046.1|",2303,0,"PREDICTED: serine protease HTRA1 isoform X2 [Ovis aries musimon]","gi|530719542|ref|NM_001282082.1|",2061,0,"Bos taurus HtrA serine peptidase 1 (HTRA1), mRNA","F1N152",889,0,"Serine protease HTRA1","alr2758",209,{"v":4e-59,"d":"4.00E-59"},"COG0265","pfam13365","Trypsin_2","Trypsin-like peptidase domain. This family includes trypsin like peptidase domains.","GO:0060718|chorionic trophoblast cell differentiation;GO:0030514|negative regulation of BMP signaling pathway;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0001890|placenta development;GO:0001558|regulation of cell growth;","GO:0005829|cytosol;GO:0005576|extracellular region;GO:0005886|plasma membrane;","GO:0042802|identical protein binding;GO:0005520|insulin-like growth factor binding;GO:0004252|serine-type endopeptidase activity;","K08784","HTRA1, PRSS11; HtrA serine peptidase 1 [EC:3.4.21.-]"]
["gene30918",1241,248,325,504.521952279606,127,213,157,182.309643135391,2.76739037827486,1.46852617017701,{"v":6.00663671245594e-05,"d":"6.01E-05"},0.00191053904172888,"up","yes","CHST15","protein_coding","chrNC_037353.1:43712673-43793152:-","gi|529009357|ref|XP_005225918.1|",3048,0,"PREDICTED: carbohydrate sulfotransferase 15 [Bos taurus]","gi|983008153|ref|XR_001499674.1|",4384,0,"PREDICTED: Bos taurus carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 (CHST15), transcript variant X1, misc_RNA","Q7LFX5",1088,0,"Carbohydrate sulfotransferase 15",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.","GO:0030206|chondroitin sulfate biosynthetic process;GO:0019319|hexose biosynthetic process;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0050656|3'-phosphoadenosine 5'-phosphosulfate binding;GO:0050659|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity;","K08106","CHST15; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase [EC:2.8.2.33]"]
["gene30924",1221,1893,1281,1332.01335156707,489,390,454,489.779439364063,2.71961876002099,1.44340442663145,{"v":1.41236895161512e-08,"d":"1.41E-08"},{"v":1.45474002016357e-06,"d":"1.45E-06"},"up","yes","OAT","protein_coding","chrNC_037353.1:44045035-44064355:-","gi|926725286|ref|XP_013830726.1|",2145,0,"PREDICTED: ornithine aminotransferase, mitochondrial [Capra hircus]","gi|77735430|ref|NM_001034240.1|",2359,0,"Bos taurus ornithine aminotransferase (OAT), mRNA","Q3ZCF5",827,0,"Ornithine aminotransferase, mitochondrial","SPBC21C3.08c",446,{"v":6e-148,"d":"6.00E-148"},"COG4992","pfam00202","Aminotran_3","Aminotransferase class-III.","GO:0055129|L-proline biosynthetic process;GO:0034214|protein hexamerization;","GO:0005759|mitochondrial matrix;","GO:0042802|identical protein binding;GO:0004587|ornithine-oxo-acid transaminase activity;GO:0030170|pyridoxal phosphate binding;","K00819","rocD, OAT; ornithine--oxo-acid transaminase [EC:2.6.1.13]"]
["gene30926",1105,1866,2162,1563.50683796423,486,690,598,650.734501727609,2.40268010043011,1.26464457678839,{"v":7.70228900654907e-07,"d":"7.70E-07"},{"v":4.82975840979893e-05,"d":"4.83E-05"},"up","yes","LHPP","protein_coding","chrNC_037353.1:44097549-44224863:+","gi|124249262|ref|NP_001074381.1|",1254,{"v":5e-168,"d":"5.00E-168"},"phospholysine phosphohistidine inorganic pyrophosphate phosphatase [Bos taurus]","gi|124249261|ref|NM_001080912.1|",1594,0,"Bos taurus phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP), mRNA","Q0VD18",487,{"v":2e-169,"d":"2.00E-169"},"Phospholysine phosphohistidine inorganic pyrophosphate phosphatase","Rv1225c",76.3,{"v":1e-14,"d":"1.00E-14"},"COG0647","pfam13344","Hydrolase_6","Haloacid dehalogenase-like hydrolase. This family is part of the HAD superfamily.","GO:0006796|phosphate-containing compound metabolic process;GO:0006470|protein dephosphorylation;","GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0005634|nucleus;","GO:0004427|inorganic diphosphatase activity;GO:0000287|magnesium ion binding;GO:0042803|protein homodimerization activity;","K11725","LHPP; phospholysine phosphohistidine inorganic pyrophosphate phosphatase [EC:3.6.1.1 3.1.3.-]"]
["gene30927",3345,4031,4471,3565.95551596072,1507,1032,1444,1463.24453403221,2.4370195363957,1.28511781648932,{"v":2.30626383571656e-06,"d":"2.31E-06"},0.000123248321883854,"up","yes","FAM53B","protein_coding","chrNC_037353.1:44228181-44341994:-","gi|741903267|ref|XP_010799424.1|",1720,0,"PREDICTED: protein FAM53B isoform X1 [Bos taurus]","gi|965785452|ref|XM_012108606.2|",4105,0,"PREDICTED: Ovis aries musimon family with sequence similarity 53 member B (FAM53B), transcript variant X2, mRNA","Q14153",502,{"v":6e-160,"d":"6.00E-160"},"Protein FAM53B",".",".",".",".","pfam15242","FAM53","Family of FAM53. The FAM53 protein family refers to a family of proteins, which bind to a transcriptional regulator that modulates cell proliferation. It is known to be highly important in neural tube development. It is found in eukaryotes and is typically between 303 and 413 amino acids in length.","GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0060828|regulation of canonical Wnt signaling pathway;GO:0016055|Wnt signaling pathway;","GO:0005634|nucleus;",".",".","."]
["gene31007",36,215,67,100.418887007264,18,12,15,16.5462697779999,6.06897435824369,2.60145272516294,{"v":1.88636627210049e-07,"d":"1.89E-07"},{"v":1.4428931932788e-05,"d":"1.44E-05"},"up","yes","LRRC27","protein_coding","chrNC_037353.1:51936286-51962993:+","gi|982968941|ref|XP_005225957.2|",3338,0,"PREDICTED: leucine-rich repeat-containing protein 27 isoform X1 [Bos taurus]","gi|983008281|ref|XM_010826025.2|",3145,0,"PREDICTED: Bos taurus leucine rich repeat containing 27 (LRRC27), transcript variant X2, mRNA","Q9C0I9",392,{"v":9e-123,"d":"9.00E-123"},"Leucine-rich repeat-containing protein 27","YAL021c_1",57.8,{"v":1e-07,"d":"1.00E-07"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007165|signal transduction;","GO:0005886|plasma membrane;",".",".","."]
["gene3103",1502,415,517,686.240823174114,282,235,275,290.912224469298,2.35892742020725,1.23813103022725,{"v":1.2034052692831e-05,"d":"1.20E-05"},0.000501964265174212,"up","yes","PEAR1","protein_coding","chrNC_037330.1:13938885-13959673:-","gi|155372315|ref|NP_001094770.1|",4842,0,"platelet endothelial aggregation receptor 1 precursor [Bos taurus]","gi|982916440|ref|XM_005203783.3|",4278,0,"PREDICTED: Bos taurus platelet endothelial aggregation receptor 1 (PEAR1), transcript variant X1, mRNA","Q5VY43",1600,0,"Platelet endothelial aggregation receptor 1",".",".",".",".","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.","GO:0045746|negative regulation of Notch signaling pathway;GO:0043654|recognition of apoptotic cell;","GO:0016021|integral component of membrane;GO:0001891|phagocytic cup;",".",".","."]
["gene31033",919,112,416,403.979734304587,41,39,51,48.0466241992839,8.40807738393841,3.07177594723901,{"v":3.56168628028101e-20,"d":"3.56E-20"},{"v":2.41948741101661e-17,"d":"2.42E-17"},"up","yes","ANGPT2","protein_coding","chrNC_037354.1:5554569-5612326:-","gi|157426837|ref|NP_001092325.1|",2684,0,"angiopoietin-2 precursor [Bos taurus]","gi|157426836|ref|NM_001098855.1|",2670,0,"Bos taurus angiopoietin 2 (ANGPT2), mRNA","O77802",1038,0,"Angiopoietin-2",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0001525|angiogenesis;GO:0030154|cell differentiation;GO:0016525|negative regulation of angiogenesis;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0010812|negative regulation of cell-substrate adhesion;GO:0050928|negative regulation of positive chemotaxis;GO:0048014|Tie signaling pathway;","GO:0005615|extracellular space;","GO:0046872|metal ion binding;GO:0030971|receptor tyrosine kinase binding;","K05466","ANGPT2; angiopoietin 2"]
["gene31057",1918,11811,6842,6471.87509450754,1306,1418,2152,1785.34315455987,3.62500344988468,1.85798236812872,{"v":9.90363883117525e-07,"d":"9.90E-07"},{"v":6.05055073859231e-05,"d":"6.05E-05"},"up","yes","LOC112444653","rRNA","chrNC_037354.1:6222648-6222800:-","gi|954258002|gb|KRX51787.1|",138,{"v":1e-08,"d":"1.00E-08"},"hypothetical protein T09_8305 [Trichinella sp. T9]","gi|958786664|ref|XM_014867045.1|",153,{"v":3e-73,"d":"3.00E-73"},"PREDICTED: Equus asinus translation initiation factor IF-2-like (LOC106847650), mRNA",".",".",".",".",".",".",".",".","pfam05346","DUF747","Eukaryotic membrane protein family. This family is a family of eukaryotic membrane proteins. It was previously annotated as including a putative receptor for human cytomegalovirus gH but this has has since been disputed. Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation 1) has shown it to be involved in patterning of the vertebrate axial skeleton.",".",".",".",".","."]
["gene3110",123,208,188,157.960802524148,53,59,77,69.2568877610757,2.28079556605381,1.18953713974171,0.00200271155985205,0.0308399571167708,"up","yes","RRNAD1","protein_coding","chrNC_037330.1:14098948-14105919:-","gi|296489688|tpg|DAA31801.1|",2182,0,"TPA: hypothetical protein LOC532204 [Bos taurus]","gi|62751404|ref|NM_001015641.1|",1892,0,"Bos taurus ribosomal RNA adenine dimethylase domain containing 1 (RRNAD1), mRNA","Q5E9V4",843,0,"Protein RRNAD1",".",".",".",".","pfam13679","Methyltransf_32","Methyltransferase domain. This family appears to be a methyltransferase domain.",".","GO:0016021|integral component of membrane;","GO:0000179|rRNA (adenine-N6,N6-)-dimethyltransferase activity;",".","."]
["gene31204",119,187,118,128.537723960898,29,48,41,43.2545663534379,2.97165674741949,1.57126748149055,0.000166576885610925,0.00442207954171375,"up","yes","MTMR7","protein_coding","chrNC_037354.1:19848025-19948595:+","gi|115497208|ref|NP_001069109.1|",3477,0,"myotubularin-related protein 7 [Bos taurus]","gi|115497207|ref|NM_001075641.1|",2691,0,"Bos taurus myotubularin related protein 7 (MTMR7), mRNA","Q9Y216",1282,0,"Myotubularin-related protein 7",".",".",".",".","pfam06602","Myotub-related","Myotubularin-like phosphatase domain. This family represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with disease.","GO:0046855|inositol phosphate dephosphorylation;GO:0006661|phosphatidylinositol biosynthetic process;GO:0046856|phosphatidylinositol dephosphorylation;GO:0006470|protein dephosphorylation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;","GO:0052629|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity;GO:0004438|phosphatidylinositol-3-phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;","K18083","MTMR6_7_8; myotubularin-related protein 6/7/8 [EC:3.1.3.64 3.1.3.95]"]
["gene3121",133,13,44,52.4365722076583,5,9,15,10.586321898628,4.9532380282574,2.30837195146602,0.00023248066953805,0.00566915041247017,"up","yes","IQGAP3","protein_coding","chrNC_037330.1:14259613-14299014:+","gi|149642679|ref|NP_001092350.1|",7739,0,"ras GTPase-activating-like protein IQGAP3 [Bos taurus]","gi|149642678|ref|NM_001098880.1|",5821,0,"Bos taurus IQ motif containing GTPase activating protein 3 (IQGAP3), mRNA","Q86VI3",2679,0,"Ras GTPase-activating-like protein IQGAP3","SPAC4F8.13c",268,{"v":1e-71,"d":"1.00E-71"},"COG5261","pfam00616","RasGAP","GTPase-activator protein for Ras-like GTPase. All alpha-helical domain that accelerates the GTPase activity of Ras, thereby \"switching\" it into an \"off\" position.","GO:0000187|activation of MAPK activity;GO:0071310|cellular response to organic substance;GO:0070371|ERK1 and ERK2 cascade;GO:0000082|G1/S transition of mitotic cell cycle;GO:0010629|negative regulation of gene expression;GO:0010628|positive regulation of gene expression;GO:0033601|positive regulation of mammary gland epithelial cell proliferation;GO:0007265|Ras protein signal transduction;GO:0008361|regulation of cell size;GO:0043087|regulation of GTPase activity;","GO:0005911|cell-cell junction;GO:0005829|cytosol;GO:0016328|lateral plasma membrane;","GO:0005516|calmodulin binding;GO:0070856|myosin VI light chain binding;GO:0017048|Rho GTPase binding;","K05767","IQGAP2_3; Ras GTPase-activating-like protein IQGAP2/3"]
["gene31223",12,46,24,25.5734112921322,5,3,5,4.77466760015896,5.35606107769278,2.42117241248859,0.0024868300985631,0.035979589017294,"up","yes","TRMT9B","protein_coding","chrNC_037354.1:23989199-24059041:-","gi|116003885|ref|NP_001070300.1|",2440,0,"probable tRNA methyltransferase 9-like protein [Bos taurus]","gi|742113642|ref|XM_010838827.1|",3373,0,"PREDICTED: Bison bison bison KIAA1456 ortholog (KIAA1456), transcript variant X1, mRNA","Q08DH3",944,0,"Probable tRNA methyltransferase 9B","SPAC13D6.03c",147,{"v":5e-38,"d":"5.00E-38"},"COG0500","pfam08241","Methyltransf_11","Methyltransferase domain. Members of this family are SAM dependent methyltransferases.","GO:0002098|tRNA wobble uridine modification;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0008198|ferrous iron binding;GO:0016706|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0016300|tRNA (uracil) methyltransferase activity;GO:0000049|tRNA binding;",".","."]
["gene31228",1212,242,451,533.694898170737,196,226,251,246.801931269615,2.16244214713097,1.11266153614186,0.000177917392706516,0.00461593019016041,"up","yes","PRAG1","protein_coding","chrNC_037354.1:24423846-24471104:-","gi|529009892|ref|XP_005226091.1|",6518,0,"PREDICTED: tyrosine-protein kinase SgK223 isoform X1 [Bos taurus]","gi|983008566|ref|XM_015469735.1|",4754,0,"PREDICTED: Bos taurus tyrosine-protein kinase SgK223 (LOC533821), transcript variant X2, mRNA","Q86YV5",1884,0,"Tyrosine-protein kinase PRAG1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.",".","GO:0005737|cytoplasm;GO:0005925|focal adhesion;","GO:0005524|ATP binding;GO:0042802|identical protein binding;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0004672|protein kinase activity;","K17537","SGK223; tyrosine-protein kinase SgK223 [EC:2.7.10.2]"]
["gene3123",8753,14376,13470,11129.4329530025,3782,4073,4306,4462.6805432529,2.49388968023467,1.31839764748573,{"v":1.28468466822896e-06,"d":"1.28E-06"},{"v":7.6044270268134e-05,"d":"7.60E-05"},"up","yes","MEF2D","protein_coding","chrNC_037330.1:14323436-14362406:+","gi|528942090|ref|XP_005203659.1|",2061,0,"PREDICTED: myocyte-specific enhancer factor 2D isoform X1 [Bos taurus]","gi|965833589|ref|XM_012132470.2|",5129,0,"PREDICTED: Ovis aries musimon myocyte enhancer factor 2D (MEF2D), transcript variant X2, mRNA","Q63943",781,0,"Myocyte-specific enhancer factor 2D","YPL089c",92.4,{"v":6e-18,"d":"6.00E-18"},"COG5068","pfam00319","SRF-TF","SRF-type transcription factor (DNA-binding and dimerization domain).","GO:0007512|adult heart development;GO:0006915|apoptotic process;GO:0002062|chondrocyte differentiation;GO:0001958|endochondral ossification;GO:0007399|nervous system development;GO:0001649|osteoblast differentiation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:0006355|regulation of transcription, DNA-templated;GO:0035914|skeletal muscle cell differentiation;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0033613|activating transcription factor binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019899|enzyme binding;GO:0042826|histone deacetylase binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09262","MEF2D; MADS-box transcription enhancer factor 2D"]
["gene31288",648,575,1558,835.817028175078,282,307,357,346.935106289704,2.40914514853719,1.26852131709919,{"v":5.0121372279944e-06,"d":"5.01E-06"},0.000235586964171183,"up","yes","RNF122","protein_coding","chrNC_037354.1:29247805-29265952:-","gi|966006424|ref|XP_014960013.1|",859,{"v":2e-107,"d":"2.00E-107"},"PREDICTED: RING finger protein 122 isoform X1, partial [Ovis aries]","gi|982969425|ref|XM_005226045.3|",2013,0,"PREDICTED: Bos taurus ring finger protein 122 (RNF122), transcript variant X1, mRNA","Q8BP31",318,{"v":3e-103,"d":"3.00E-103"},"RING finger protein 122","SPAC57A7.09",60.1,{"v":8e-09,"d":"8.00E-09"},"COG5540","pfam13639","zf-RING_2","Ring finger domain.","GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209|protein polyubiquitination;","GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K15699","RNF122; RING finger protein 122"]
["gene31302",881,2422,2044,1651.09790978603,306,574,549,523.198015957345,3.15578014332653,1.6579966992737,{"v":6.49735989125507e-05,"d":"6.50E-05"},0.00202818572272865,"up","yes","ZNF703","protein_coding","chrNC_037354.1:32978689-32981447:+","gi|300795399|ref|NP_001178409.1|",1665,0,"zinc finger protein 703 [Bos taurus]","gi|300795398|ref|NM_001191480.1|",1732,0,"Bos taurus zinc finger protein 703 (ZNF703), mRNA","Q9H7S9",365,{"v":2e-173,"d":"2.00E-173"},"Zinc finger protein 703",".",".",".",".","pfam12402","nlz1","NocA-like zinc-finger protein 1. This domain family is found in eukaryotes, and is typically between 42 and 57 amino acids in length. There is a conserved GAY sequence motif. There is a single completely conserved residue G that may be functionally important. Nlz1 self-associated via its C terminus, interacted with Nlz2, and bound to histone deacetylases.","GO:0034333|adherens junction assembly;GO:0071392|cellular response to estradiol stimulus;GO:0060644|mammary gland epithelial cell differentiation;GO:0034111|negative regulation of homotypic cell-cell adhesion;GO:0045892|negative regulation of transcription, DNA-templated;GO:0030335|positive regulation of cell migration;GO:0008284|positive regulation of cell proliferation;GO:0010718|positive regulation of epithelial to mesenchymal transition;GO:0033601|positive regulation of mammary gland epithelial cell proliferation;GO:0060828|regulation of canonical Wnt signaling pathway;GO:0051726|regulation of cell cycle;GO:0006355|regulation of transcription, DNA-templated;GO:0017015|regulation of transforming growth factor beta receptor signaling pathway;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0016363|nuclear matrix;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0046872|metal ion binding;GO:0003676|nucleic acid binding;GO:0070491|repressing transcription factor binding;",".","."]
["gene31345",0,21,1,7.18919289694653,0,0,0,0,"Inf","Inf",0.00369955770140843,0.0481704868127699,"up","yes","ADAM2","protein_coding","chrNC_037354.1:34592557-34693925:-","gi|56687500|ref|NP_776653.1|",3854,0,"disintegrin and metalloproteinase domain-containing protein 2 precursor [Bos taurus]","gi|942059173|ref|XM_005897530.2|",2582,0,"PREDICTED: Bos mutus ADAM metallopeptidase domain 2 (ADAM2), mRNA","O77780",1489,0,"Disintegrin and metalloproteinase domain-containing protein 2",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0007155|cell adhesion;GO:0007338|single fertilization;","GO:0016021|integral component of membrane;","GO:0004222|metalloendopeptidase activity;","K06833","ADAM2; disintegrin and metalloproteinase domain-containing protein 2 [EC:3.4.24.-]"]
["gene31346",0,46,1,15.3821348771113,1,0,0,0.373768090184884,41.1542217782757,5.36296853103036,0.000135056768728162,0.00374107249377009,"up","yes","ADAM3A","protein_coding","chrNC_037354.1:34708241-34822441:-","gi|296472308|tpg|DAA14423.1|",3743,0,"TPA: ADAM metallopeptidase domain 3A (cyritestin 1) [Bos taurus]","gi|402745300|ref|NM_001098166.2|",2223,0,"Bos taurus ADAM metallopeptidase domain 3A (cyritestin 1) (ADAM3A), mRNA","F8VQ03",748,0,"A disintegrin and metallopeptidase domain 3",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0007339|binding of sperm to zona pellucida;GO:0009566|fertilization;GO:0010628|positive regulation of gene expression;GO:0050684|regulation of mRNA processing;GO:0007338|single fertilization;","GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0045121|membrane raft;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;","GO:0004222|metalloendopeptidase activity;",".","."]
["gene31374",442,719,823,603.585586490613,171,206,210,215.318089208621,2.80322748873087,1.48708882733385,{"v":1.36494355380429e-07,"d":"1.36E-07"},{"v":1.09391023970759e-05,"d":"1.09E-05"},"up","yes","PLAT","protein_coding","chrNC_037354.1:37053712-37077724:-","gi|2499868|sp|Q28198.1|TPA_BOVIN",3062,0,"RecName: Full=Tissue-type plasminogen activator; Short=t-PA; Short=t-plasminogen activator; Short=tPA; Contains: RecName: Full=Tissue-type plasminogen activator chain A; Contains: RecName: Full=Tissue-type plasminogen activator chain B; Flags: Precursor","gi|88853807|ref|NM_174146.3|",2457,0,"Bos taurus plasminogen activator, tissue type (PLAT), mRNA","Q28198",1184,0,"Tissue-type plasminogen activator","mlr3307",110,{"v":4e-25,"d":"4.00E-25"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0045861|negative regulation of proteolysis;GO:0031639|plasminogen activation;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0006508|proteolysis;GO:0001666|response to hypoxia;GO:0014909|smooth muscle cell migration;","GO:0045177|apical part of cell;GO:0009986|cell surface;GO:0005615|extracellular space;GO:0030141|secretory granule;","GO:0051219|phosphoprotein binding;GO:0004252|serine-type endopeptidase activity;GO:0097655|serpin family protein binding;GO:0005102|receptor binding;","K01343","PLAT; tissue plasminogen activator [EC:3.4.21.68]"]
["gene31394",346,60,119,146.386175097089,31,35,53,43.5629387983838,3.36033745966009,1.74860612197172,{"v":2.29288662895629e-05,"d":"2.29E-05"},0.000850693737461014,"up","yes","CSGALNACT1","protein_coding","chrNC_037354.1:37895018-38233887:+","gi|529010226|ref|XP_005226213.1|",2604,0,"PREDICTED: chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1 [Bos taurus]","gi|402747086|ref|NM_001102116.2|",3396,0,"Bos taurus chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1), mRNA","Q8TDX6",864,0,"Chondroitin sulfate N-acetylgalactosaminyltransferase 1",".",".",".",".","pfam05679","CHGN","Chondroitin N-acetylgalactosaminyltransferase.","GO:0009653|anatomical structure morphogenesis;GO:0051216|cartilage development;GO:0008283|cell proliferation;GO:0008037|cell recognition;GO:0030206|chondroitin sulfate biosynthetic process;GO:0050650|chondroitin sulfate proteoglycan biosynthetic process;GO:0050653|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process;GO:0050651|dermatan sulfate proteoglycan biosynthetic process;GO:0001958|endochondral ossification;GO:0030198|extracellular matrix organization;GO:0015014|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process;GO:0030210|heparin biosynthetic process;GO:0007399|nervous system development;GO:0030166|proteoglycan biosynthetic process;GO:0046398|UDP-glucuronate metabolic process;GO:0019276|UDP-N-acetylgalactosamine metabolic process;","GO:0032580|Golgi cisterna membrane;GO:0000139|Golgi membrane;GO:0030173|integral component of Golgi membrane;GO:0005622|intracellular;","GO:0008376|acetylgalactosaminyltransferase activity;GO:0047238|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0015020|glucuronosyltransferase activity;GO:0047237|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0046872|metal ion binding;GO:0008955|peptidoglycan glycosyltransferase activity;","K00746","CSGALNACT1_2; chondroitin sulfate N-acetylgalactosaminyltransferase 1/2 [EC:2.4.1.174 2.4.1.175]"]
["gene31397",50,33,13,27.8384264925334,5,7,3,5.52067209921025,5.0425792353282,2.33416184844992,0.00200404053466381,0.0308399571167708,"up","yes","SH2D4A","protein_coding","chrNC_037354.1:38241768-38307784:-","gi|528927272|ref|XP_005197272.1|",2086,0,"PREDICTED: SH2 domain-containing protein 4A [Bos taurus]","gi|983008708|ref|XM_005197215.3|",2222,0,"PREDICTED: Bos taurus SH2 domain containing 4A (SH2D4A), mRNA","Q9H788",605,0,"SH2 domain-containing protein 4A",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0010923|negative regulation of phosphatase activity;","GO:0005829|cytosol;","GO:0019902|phosphatase binding;","K17577","SH2D4A; SH2 domain-containing protein 4A"]
["gene31461",99,238,182,159.694645414628,46,63,55,60.1670578597679,2.65418737586987,1.40827022326876,0.000285833321518376,0.00673801903962214,"up","yes","RHOU","protein_coding","chrNC_037355.1:697339-706885:+","gi|803337667|ref|XP_012026919.1|",1085,{"v":7e-138,"d":"7.00E-138"},"PREDICTED: rho-related GTP-binding protein RhoU [Ovis aries musimon]","gi|148223775|ref|NM_001098147.1|",2735,0,"Bos taurus ras homolog family member U (RHOU), mRNA","A5D7J5",420,{"v":2e-138,"d":"2.00E-138"},"Rho-related GTP-binding protein RhoU",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0030036|actin cytoskeleton organization;GO:0007010|cytoskeleton organization;GO:0000082|G1/S transition of mitotic cell cycle;GO:0016601|Rac protein signal transduction;GO:0008360|regulation of cell shape;","GO:0042995|cell projection;GO:0005925|focal adhesion;GO:0000139|Golgi membrane;GO:0005886|plasma membrane;GO:0002102|podosome;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0046872|metal ion binding;","K07865","RHOU, WRCH1; Ras homolog gene family, member U"]
["gene31516",3232,4200,4191,3505.89532057387,1334,1613,1377,1587.61724848672,2.20827489995816,1.14291977905445,{"v":4.80949734928875e-06,"d":"4.81E-06"},0.000228319082982625,"up","yes","IRF2BP2","protein_coding","chrNC_037355.1:7398126-7403517:-","gi|926726027|ref|XP_013830995.1|",1806,0,"PREDICTED: interferon regulatory factor 2-binding protein 2 [Capra hircus]","gi|926726026|ref|XM_013975541.1|",4418,0,"PREDICTED: Capra hircus interferon regulatory factor 2 binding protein 2 (IRF2BP2), mRNA","Q7Z5L9",678,0,"Interferon regulatory factor 2-binding protein 2",".",".",".",".","pfam11261","IRF-2BP1_2","Interferon regulatory factor 2-binding protein zinc finger. IRF-2BP1 and IRF-2BP2 are nuclear transcriptional repressor proteins and can inhibit both enhancer-activated and basal transcription. They both contain N-terminal zinc finger represented in this family and C-terminal RING finger domains.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;",".","."]
["gene31574",1172,1246,3365,1747.25095895472,323,376,349,384.69395713993,4.54192463002263,2.18330376575533,{"v":2.44777736905565e-17,"d":"2.45E-17"},{"v":1.24709885922369e-14,"d":"1.25E-14"},"up","yes","RET","protein_coding","chrNC_037355.1:13467109-13524201:+","gi|296472216|tpg|DAA14331.1|",5826,0,"TPA: ret proto-oncogene [Bos taurus]","gi|594053027|ref|XM_006050752.1|",5127,0,"PREDICTED: Bubalus bubalis ret proto-oncogene (RET), transcript variant X1, mRNA","P07949",1958,0,"Proto-oncogene tyrosine-protein kinase receptor Ret",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0000187|activation of MAPK activity;GO:0007411|axon guidance;GO:0071300|cellular response to retinoic acid;GO:0001838|embryonic epithelial tube formation;GO:0048484|enteric nervous system development;GO:0035860|glial cell-derived neurotrophic factor receptor signaling pathway;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0060384|innervation;GO:0097021|lymphocyte migration into lymphoid organs;GO:0000165|MAPK cascade;GO:0033619|membrane protein proteolysis;GO:0001755|neural crest cell migration;GO:0007158|neuron cell-cell adhesion;GO:0042551|neuron maturation;GO:0061146|Peyer's patch morphogenesis;GO:0033630|positive regulation of cell adhesion mediated by integrin;GO:0030335|positive regulation of cell migration;GO:0045793|positive regulation of cell size;GO:2001241|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0043410|positive regulation of MAPK cascade;GO:0072300|positive regulation of metanephric glomerulus development;GO:0014042|positive regulation of neuron maturation;GO:0010976|positive regulation of neuron projection development;GO:0033141|positive regulation of peptidyl-serine phosphorylation of STAT protein;GO:0051897|positive regulation of protein kinase B signaling;GO:0045893|positive regulation of transcription, DNA-templated;GO:0007497|posterior midgut development;GO:0006468|protein phosphorylation;GO:0050770|regulation of axonogenesis;GO:0030155|regulation of cell adhesion;GO:0042493|response to drug;GO:0048265|response to pain;GO:0060041|retina development in camera-type eye;GO:0007165|signal transduction;GO:0035799|ureter maturation;GO:0001657|ureteric bud development;","GO:0030424|axon;GO:0005829|cytosol;GO:0030425|dendrite;GO:0005769|early endosome;GO:0010008|endosome membrane;GO:0005887|integral component of plasma membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0045121|membrane raft;GO:0043025|neuronal cell body;GO:0005886|plasma membrane;GO:0098797|plasma membrane protein complex;GO:0043235|receptor complex;","GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0004713|protein tyrosine kinase activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;GO:0038023|signaling receptor activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;","K05126","RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]"]
["gene31586",55,58,59,51.462079802852,10,10,6,9.57339392246273,5.37553141755745,2.42640738457696,{"v":6.6606052013749e-05,"d":"6.66E-05"},0.00207000625164031,"up","yes","SLC16A9","protein_coding","chrNC_037355.1:15307788-15393490:-","gi|358419444|ref|XP_587823.4|",2583,0,"PREDICTED: monocarboxylate transporter 9 isoform X1 [Bos taurus]","gi|983008935|ref|XM_587823.8|",3596,0,"PREDICTED: Bos taurus solute carrier family 16 member 9 (SLC16A9), transcript variant X1, mRNA","Q7RTY1",910,0,"Monocarboxylate transporter 9",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0015718|monocarboxylic acid transport;GO:0046415|urate metabolic process;","GO:0005887|integral component of plasma membrane;","GO:0008028|monocarboxylic acid transmembrane transporter activity;GO:0015293|symporter activity;","K08186","SLC16A9; MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 9"]
["gene31588",615,599,1120,700.562410140092,67,150,110,119.79761512066,5.84788277658521,2.54791439211555,{"v":1.18093546846433e-07,"d":"1.18E-07"},{"v":9.68197409504478e-06,"d":"9.68E-06"},"up","yes","MRLN","protein_coding","chrNC_037355.1:15415504-15432432:-","gi|803197960|ref|XP_011960311.1|",425,{"v":2e-51,"d":"2.00E-51"},"PREDICTED: myoregulin isoform X1 [Ovis aries]","gi|754168701|ref|NM_001304742.1|",401,0,"Bos taurus myoregulin (MRLN), mRNA","P0DMT0",81.6,{"v":1e-19,"d":"1.00E-19"},"Myoregulin",".",".",".",".","pfam05316","VAR1","Mitochondrial ribosomal protein (VAR1). This family consists of the yeast mitochondrial ribosomal proteins VAR1. Mitochondria possess their own ribosomes responsible for the synthesis of a small number of proteins encoded by the mitochondrial genome. In yeast the two ribosomal RNAs and a single ribosomal protein, VAR1, are products of mitochondrial genes, and the remaining approximately 80 ribosomal proteins are encoded in the nucleus. VAR1 along with 15S rRNA are necessary for the formation of mature 37S subunits.","GO:1902081|negative regulation of calcium ion import into sarcoplasmic reticulum;GO:0009611|response to wounding;","GO:0016021|integral component of membrane;GO:0033017|sarcoplasmic reticulum membrane;","GO:0004857|enzyme inhibitor activity;",".","."]
["gene31589",3547,7696,5814,5232.15105802948,1629,1901,1824,1964.92613609882,2.66277238716842,1.41292911276268,{"v":5.34208974449712e-08,"d":"5.34E-08"},{"v":4.82326463608377e-06,"d":"4.82E-06"},"up","yes","CCDC6","protein_coding","chrNC_037355.1:15458897-15571339:-","gi|926726158|ref|XP_013831041.1|",1718,0,"PREDICTED: LOW QUALITY PROTEIN: coiled-coil domain-containing protein 6, partial [Capra hircus]","gi|983008938|ref|XM_015469822.1|",5947,0,"PREDICTED: Bos taurus coiled-coil domain containing 6 (CCDC6), transcript variant X2, mRNA","Q16204",639,0,"Coiled-coil domain-containing protein 6",".",".",".",".","pfam09755","DUF2046","Uncharacterized conserved protein H4 (DUF2046). This is the conserved N-terminal 350 residues of a family of proteins of unknown function possibly containing a coiled-coil domain.",".","GO:0005856|cytoskeleton;GO:0005829|cytosol;","GO:0017124|SH3 domain binding;GO:0005200|structural constituent of cytoskeleton;","K09288","CCDC6, PTC; coiled-coil domain-containing protein 6"]
["gene31596",5635,6645,4786,5116.18005634823,1326,2546,1760,2065.27912190999,2.47723419177197,1.30873026395648,0.00116667459850159,0.0203960741236819,"up","yes","RHOBTB1","protein_coding","chrNC_037355.1:16636263-16777512:-","gi|529010610|ref|XP_005226359.1|",3475,0,"PREDICTED: rho-related BTB domain-containing protein 1 isoform X1 [Bos taurus]","gi|982970094|ref|XM_015460981.1|",3883,0,"PREDICTED: Bos taurus Rho-related BTB domain containing 1 (RHOBTB1), transcript variant X5, mRNA","O94844",1232,0,"Rho-related BTB domain-containing protein 1",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0051056|regulation of small GTPase mediated signal transduction;GO:0007264|small GTPase mediated signal transduction;","GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07868","RHOBTB1_2; Rho-related BTB domain-containing protein 1/2"]
["gene31617",11049,7205,9863,8269.9726947635,2933,2900,2991,3240.1956679453,2.5523065710435,1.35180162924395,{"v":1.95706601774943e-07,"d":"1.96E-07"},{"v":1.48502794022364e-05,"d":"1.49E-05"},"up","yes","JMJD1C","protein_coding","chrNC_037355.1:19314346-19630557:-","gi|529010632|ref|XP_005226370.1|",11626,0,"PREDICTED: probable JmjC domain-containing histone demethylation protein 2C isoform X1 [Bos taurus]","gi|966005157|ref|XM_012105139.2|",8741,0,"PREDICTED: Ovis aries jumonji domain containing 1C (JMJD1C), transcript variant X4, mRNA","Q15652",4049,0,"Probable JmjC domain-containing histone demethylation protein 2C",".",".",".",".","pfam02373","JmjC","JmjC domain, hydroxylase. The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyse a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalyzing hydroxylation.","GO:0007596|blood coagulation;GO:0033169|histone H3-K9 demethylation;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0000785|chromatin;GO:0005622|intracellular;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0031490|chromatin DNA binding;GO:0051213|dioxygenase activity;GO:0032454|histone demethylase activity (H3-K9 specific);GO:0046872|metal ion binding;GO:0046966|thyroid hormone receptor binding;GO:0000976|transcription regulatory region sequence-specific DNA binding;","K11449","JMJD1C; jumonji domain-containing protein 1C [EC:1.14.11.-]"]
["gene31695",1422,355,253,564.647792202283,113,168,127,149.73326261468,3.77102443600213,1.91495649908336,{"v":1.4154379884147e-10,"d":"1.42E-10"},{"v":2.24316467741421e-08,"d":"2.24E-08"},"up","yes","UNC5B","protein_coding","chrNC_037355.1:27352170-27443534:+","gi|529010829|ref|XP_005226459.1|",4613,0,"PREDICTED: netrin receptor UNC5B isoform X1 [Bos taurus]","gi|982970279|ref|XM_005226402.3|",6816,0,"PREDICTED: Bos taurus unc-5 netrin receptor B (UNC5B), transcript variant X1, mRNA","Q8IZJ1",1704,0,"Netrin receptor UNC5B",".",".",".",".","pfam00791","ZU5","ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.","GO:0001525|angiogenesis;GO:0033564|anterior/posterior axon guidance;GO:0006915|apoptotic process;GO:2001240|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;GO:0043524|negative regulation of neuron apoptotic process;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;","GO:0016021|integral component of membrane;GO:0045121|membrane raft;GO:0005886|plasma membrane;","GO:0005042|netrin receptor activity;","K07521","UNC5; netrin receptor unc-5"]
["gene31698",1433,434,582,694.447361921867,206,297,222,266.127515804571,2.60945344122864,1.38374766112387,{"v":8.08205414266694e-07,"d":"8.08E-07"},{"v":5.02372738005295e-05,"d":"5.02E-05"},"up","yes","CDH23","protein_coding","chrNC_037355.1:27529727-27963950:+","gi|296472179|tpg|DAA14294.1|",17153,0,"TPA: cadherin-23-like [Bos taurus]","gi|300794777|ref|NM_001191206.1|",10778,0,"Bos taurus cadherin-related 23 (CDH23), mRNA","Q9H251",6315,0,"Cadherin-23",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0006816|calcium ion transport;GO:0016339|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0050957|equilibrioception;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0060122|inner ear receptor stereocilium organization;GO:0007626|locomotory behavior;GO:0045494|photoreceptor cell maintenance;GO:0051480|cytosolic calcium ion homeostasis;GO:0050896|response to stimulus;GO:0050953|sensory perception of light stimulus;GO:0007605|sensory perception of sound;GO:0007601|visual perception;","GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0032420|stereocilium;","GO:0005509|calcium ion binding;","K06813","CDH23; cadherin 23"]
["gene31704",752,529,565,542.875049389696,121,128,123,136.600013022769,3.97419471182047,1.99066255776529,{"v":5.95872142775598e-12,"d":"5.96E-12"},{"v":1.2687185153381e-09,"d":"1.27E-09"},"up","yes","SPOCK2","protein_coding","chrNC_037355.1:28145188-28170447:-","gi|989969770|ref|XP_006915599.2|",1810,0,"PREDICTED: testican-2 [Pteropus alecto]","gi|155371958|ref|NM_001101115.1|",5097,0,"Bos taurus sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 (SPOCK2), mRNA","Q92563",682,0,"Testican-2",".",".",".",".","pfam10591","SPARC_Ca_bdg","Secreted protein acidic and rich in cysteine Ca binding region. The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2.","GO:1990830|cellular response to leukemia inhibitory factor;GO:0030198|extracellular matrix organization;GO:0010951|negative regulation of endopeptidase activity;GO:0019800|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan;GO:2000147|positive regulation of cell motility;GO:0010811|positive regulation of cell-substrate adhesion;GO:0045595|regulation of cell differentiation;GO:0007165|signal transduction;GO:0007416|synapse assembly;","GO:0031012|extracellular matrix;","GO:0005509|calcium ion binding;GO:0050840|extracellular matrix binding;GO:0005539|glycosaminoglycan binding;GO:0008191|metalloendopeptidase inhibitor activity;","K08136","SPOCK; sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican)"]
["gene31705",4290,1634,1435,2094.28391807854,510,404,467,507.45904277369,4.12700088391669,2.04509374733988,{"v":5.46025601118166e-16,"d":"5.46E-16"},{"v":2.22552234650034e-13,"d":"2.23E-13"},"up","yes","ASCC1","protein_coding","chrNC_037355.1:28177852-28287517:-","gi|742172796|ref|XP_010850555.1|",2079,0,"PREDICTED: activating signal cointegrator 1 complex subunit 1 isoform X1 [Bison bison bison]","gi|982970338|ref|XR_816208.2|",2357,0,"PREDICTED: Bos taurus activating signal cointegrator 1 complex subunit 1 (ASCC1), transcript variant X3, misc_RNA","Q9D8Z1",634,0,"Activating signal cointegrator 1 complex subunit 1",".",".",".",".","pfam10469","AKAP7_NLS","AKAP7 2'5' RNA ligase-like domain. AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localisation signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0031594|neuromuscular junction;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003723|RNA binding;","K18666","ASCC1; activating signal cointegrator complex subunit 1"]
["gene31710",6795,7564,4907,5756.83727593567,620,978,858,900.364796679186,6.39389422728276,2.67669487814458,{"v":2.01262530921689e-20,"d":"2.01E-20"},{"v":1.47236442813505e-17,"d":"1.47E-17"},"up","yes","DDIT4","protein_coding","chrNC_037355.1:28323892-28325923:+","gi|426255732|ref|XP_004021502.1|",1004,{"v":1e-130,"d":"1.00E-130"},"PREDICTED: DNA damage-inducible transcript 4 protein [Ovis aries]","gi|115495514|ref|NM_001075922.1|",1637,0,"Bos taurus DNA damage inducible transcript 4 (DDIT4), mRNA","Q08E62",390,{"v":5e-132,"d":"5.00E-132"},"DNA damage-inducible transcript 4 protein",".",".",".",".","pfam07809","RTP801_C","RTP801 C-terminal region. The members of this family are sequences similar to the C-terminal region of RTP801, the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene. Two members of this family expressed by Drosophila melanogaster, Scylla and Charybde, are designated by the GenBank as Hox targets. RTP801 is thought to be involved in various cellular processes. Its overexpression caused the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells. Moreover, the protein product of the mouse homolog of RTP801 (dig2 ) is thought to be induced by diverse apoptotic signals, and also by dexamethasone treatment.","GO:0007420|brain development;GO:0008283|cell proliferation;GO:0071549|cellular response to dexamethasone stimulus;GO:0051607|defense response to virus;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0045820|negative regulation of glycolytic process;GO:1902532|negative regulation of intracellular signal transduction;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0010801|negative regulation of peptidyl-threonine phosphorylation;GO:0032007|negative regulation of TOR signaling;GO:0030182|neuron differentiation;GO:0001764|neuron migration;GO:0048011|neurotrophin TRK receptor signaling pathway;GO:1901216|positive regulation of neuron death;GO:0032984|macromolecular complex disassembly;GO:0072593|reactive oxygen species metabolic process;GO:0001666|response to hypoxia;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005739|mitochondrion;","GO:0071889|14-3-3 protein binding;","K08270","DDIT4, REDD1; DNA-damage-inducible transcript 4"]
["gene31784",3064,4838,4554,3782.67964911894,1444,1619,1723,1755.83028322582,2.15435380358594,1.10725519916869,{"v":1.10834607695598e-05,"d":"1.11E-05"},0.000467784347953124,"up","yes","ZCCHC24","protein_coding","chrNC_037355.1:34985408-35050560:-","gi|594082490|ref|XP_006064845.1|",1177,{"v":8e-146,"d":"8.00E-146"},"PREDICTED: zinc finger CCHC domain-containing protein 24 [Bubalus bubalis]","gi|983009089|ref|XM_015469852.1|",4730,0,"PREDICTED: Bos taurus zinc finger, CCHC domain containing 24 (ZCCHC24), transcript variant X2, mRNA","Q8N2G6",451,{"v":1e-144,"d":"1.00E-144"},"Zinc finger CCHC domain-containing protein 24",".",".",".",".","pfam13695","zf-3CxxC","Zinc-binding domain. This is a family with several pairs of CxxC motifs possibly representing a multiple zinc-binding region. Only one pair of cysteines is associated with a highly conserved histidine residue.",".",".","GO:0003723|RNA binding;GO:0008270|zinc ion binding;",".","."]
["gene3181",85,42,37,47.2806181012546,10,11,14,12.8281645990781,3.68568845029104,1.88193412571187,0.00161639337447959,0.0263356904372748,"up","yes","EFNA4","protein_coding","chrNC_037330.1:15532626-15536814:-","gi|528942382|ref|XP_005203804.1|",969,{"v":3e-127,"d":"3.00E-127"},"PREDICTED: ephrin-A4 isoform X1 [Bos taurus]","gi|982916404|ref|XM_005203747.3|",1304,0,"PREDICTED: Bos taurus ephrin-A4 (EFNA4), transcript variant X1, mRNA","O08542",289,{"v":3e-94,"d":"3.00E-94"},"Ephrin-A4",".",".",".",".","pfam00812","Ephrin","Ephrin.","GO:0007411|axon guidance;GO:0046849|bone remodeling;GO:0048013|ephrin receptor signaling pathway;GO:0030316|osteoclast differentiation;","GO:0031225|anchored component of membrane;GO:0005886|plasma membrane;","GO:0046875|ephrin receptor binding;","K05462","EFNA; ephrin-A"]
["gene31830",72,314,270,204.591065397264,72,96,85,92.8248046348238,2.20405597622459,1.14016086437918,0.00196376688254429,0.0303840742548108,"up","yes","GRID1","protein_coding","chrNC_037355.1:40404330-41089781:-","gi|982970555|ref|XP_015316527.1|",5253,0,"PREDICTED: glutamate receptor ionotropic, delta-1 isoform X1 [Bos taurus]","gi|982970554|ref|XM_015461041.1|",3365,0,"PREDICTED: Bos taurus glutamate receptor, ionotropic, delta 1 (GRID1), transcript variant X1, mRNA","Q9ULK0",1962,0,"Glutamate receptor ionotropic, delta-1","alr3187_1",59.7,{"v":1e-08,"d":"1.00E-08"},"COG0834","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.","GO:0035176|social behavior;","GO:0030054|cell junction;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0045211|postsynaptic membrane;","GO:0005234|extracellular-glutamate-gated ion channel activity;GO:0004970|ionotropic glutamate receptor activity;","K05206","GRID1; glutamate receptor delta-1 subunit"]
["gene31840",6760,2220,3416,3538.4738292567,955,1130,1046,1149.22212040673,3.07901646376626,1.62246958161801,{"v":1.05272054543948e-10,"d":"1.05E-10"},{"v":1.70654374329169e-08,"d":"1.71E-08"},"up","yes","MMRN2","protein_coding","chrNC_037355.1:41550184-41569974:-","gi|742180395|ref|XP_010852690.1|",4519,0,"PREDICTED: multimerin-2 [Bison bison bison]","gi|742180394|ref|XM_010854388.1|",4717,0,"PREDICTED: Bison bison bison multimerin 2 (MMRN2), mRNA","Q9H8L6",1283,0,"Multimerin-2",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0001525|angiogenesis;GO:0090051|negative regulation of cell migration involved in sprouting angiogenesis;GO:0030948|negative regulation of vascular endothelial growth factor receptor signaling pathway;","GO:0005604|basement membrane;GO:0070062|extracellular exosome;GO:0005615|extracellular space;",".",".","."]
["gene31851",232,121,217,166.763824622957,40,60,44,52.8527848387046,3.15525142396724,1.65775496991731,{"v":1.47814893403233e-05,"d":"1.48E-05"},0.000593986862491215,"up","yes","ANXA8L1","protein_coding","chrNC_037355.1:41953896-41970251:-","gi|27806317|ref|NP_776666.1|",1668,0,"annexin A8 [Bos taurus]","gi|87578144|gb|BC113321.1|",1887,0,"Bos taurus annexin A8, mRNA (cDNA clone MGC:137766 IMAGE:8082583), complete cds","Q95L54",647,0,"Annexin A8",".",".",".",".","pfam00191","Annexin","Annexin. This family of annexins also includes giardin that has been shown to function as an annexin.","GO:0007596|blood coagulation;",".","GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;","K17096","ANXA8; annexin A8"]
["gene31967",99,45,33,50.6840099201489,6,19,13,13.9080199018009,3.64422903317718,1.86561363275286,0.00346689537597308,0.0459210733388523,"up","yes","NAALAD2","protein_coding","chrNC_037356.1:5096726-5148961:-","gi|300797860|ref|NP_001179809.1|",3829,0,"N-acetylated-alpha-linked acidic dipeptidase 2 [Bos taurus]","gi|982970990|ref|XM_005226668.3|",3227,0,"PREDICTED: Bos taurus N-acetylated alpha-linked acidic dipeptidase 2 (NAALAD2), transcript variant X3, mRNA","Q9Y3Q0",1305,0,"N-acetylated-alpha-linked acidic dipeptidase 2",".",".",".",".","pfam04253","TFR_dimer","Transferrin receptor-like dimerization domain. This domain is involved in dimerization of the transferrin receptor as shown in its crystal structure.","GO:0008652|cellular amino acid biosynthetic process;GO:0042135|neurotransmitter catabolic process;GO:0006508|proteolysis;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004180|carboxypeptidase activity;GO:0016805|dipeptidase activity;GO:0008239|dipeptidyl-peptidase activity;GO:0046872|metal ion binding;GO:0008237|metallopeptidase activity;GO:0050129|N-formylglutamate deformylase activity;GO:0008236|serine-type peptidase activity;","K01301","NAALAD; N-acetylated-alpha-linked acidic dipeptidase [EC:3.4.17.21]"]
["gene32068",254,349,255,258.887788769564,124,121,83,120.713488772267,2.14464672840307,1.10074002294385,0.000920586534829383,0.0169344000162586,"up","yes","KCTD21","protein_coding","chrNC_037356.1:17860450-17881538:+","gi|803190237|ref|XP_011957097.1|",1453,0,"PREDICTED: BTB/POZ domain-containing protein KCTD21 isoform X2 [Ovis aries]","gi|982971169|ref|XM_005226714.3|",3196,0,"PREDICTED: Bos taurus potassium channel tetramerization domain containing 21 (KCTD21), transcript variant X1, mRNA","Q4G0X4",540,0,"BTB/POZ domain-containing protein KCTD21",".",".",".",".","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0045879|negative regulation of smoothened signaling pathway;GO:0051260|protein homooligomerization;GO:0016567|protein ubiquitination;GO:0040008|regulation of growth;GO:0006511|ubiquitin-dependent protein catabolic process;",".","GO:0097602|cullin family protein binding;GO:0042826|histone deacetylase binding;GO:0042802|identical protein binding;",".","."]
["gene32083",603,981,1031,795.289259363855,262,384,332,358.693465086862,2.21718357531622,1.14872822543029,{"v":2.02633603289093e-05,"d":"2.03E-05"},0.00077084524472548,"up","yes","PAK1","protein_coding","chrNC_037356.1:18521017-18682812:+","gi|821015841|ref|XP_012361230.1|",2716,0,"PREDICTED: serine/threonine-protein kinase PAK 1 isoform X1 [Nomascus leucogenys]","gi|741979276|ref|XM_010820835.1|",3419,0,"PREDICTED: Bos taurus p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1), transcript variant X1, mRNA","Q08E52",1044,0,"Serine/threonine-protein kinase PAK 1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0030036|actin cytoskeleton organization;GO:0031532|actin cytoskeleton reorganization;GO:0032147|activation of protein kinase activity;GO:0006915|apoptotic process;GO:0048754|branching morphogenesis of an epithelial tube;GO:0016477|cell migration;GO:0006887|exocytosis;GO:0048012|hepatocyte growth factor receptor signaling pathway;GO:0060244|negative regulation of cell proliferation involved in contact inhibition;GO:0030335|positive regulation of cell migration;GO:0008284|positive regulation of cell proliferation;GO:0033148|positive regulation of intracellular estrogen receptor signaling pathway;GO:0043507|positive regulation of JUN kinase activity;GO:0031116|positive regulation of microtubule polymerization;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0051496|positive regulation of stress fiber assembly;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0042981|regulation of apoptotic process;GO:0050770|regulation of axonogenesis;GO:0043408|regulation of MAPK cascade;GO:0007346|regulation of mitotic cell cycle;GO:0007266|Rho protein signal transduction;GO:0023014|signal transduction by protein phosphorylation;GO:0031098|stress-activated protein kinase signaling cascade;GO:0042060|wound healing;","GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005925|focal adhesion;GO:0071437|invadopodium;GO:0005886|plasma membrane;GO:0032991|macromolecular complex;GO:0001726|ruffle;GO:0032587|ruffle membrane;","GO:0005524|ATP binding;GO:0005518|collagen binding;GO:0004674|protein serine/threonine kinase activity;GO:0048365|Rac GTPase binding;","K04409","PAK1; p21-activated kinase 1 [EC:2.7.11.1]"]
["gene32135",33152,82423,88791,62921.292790536,15440,25864,18822,22056.9775032645,2.85267066991492,1.51231320282391,{"v":9.72325904682299e-05,"d":"9.72E-05"},0.0028365470742833,"up","yes","LDHA","protein_coding","chrNC_037356.1:26290887-26302946:-","gi|741979392|ref|XP_010819169.1|",2055,0,"PREDICTED: L-lactate dehydrogenase A chain isoform X1 [Bos taurus]","gi|741979391|ref|XM_010820867.1|",1841,0,"PREDICTED: Bos taurus lactate dehydrogenase A (LDHA), transcript variant X1, mRNA","P19858",679,0,"L-lactate dehydrogenase A chain","CAC0267",279,{"v":4e-87,"d":"4.00E-87"},"COG0039","pfam00056","Ldh_1_N","lactate/malate dehydrogenase, NAD binding domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.","GO:0005975|carbohydrate metabolic process;GO:0019752|carboxylic acid metabolic process;","GO:0005737|cytoplasm;","GO:0004459|L-lactate dehydrogenase activity;","K00016","LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]"]
["gene32266",2279,565,960,1073.95761376523,303,285,404,363.676235423121,2.95305964250242,1.56221049466135,{"v":5.04353292924159e-09,"d":"5.04E-09"},{"v":5.6430210982036e-07,"d":"5.64E-07"},"up","yes","ROBO4","protein_coding","chrNC_037356.1:28351068-28365789:-","gi|296471799|tpg|DAA13914.1|",4085,0,"TPA: roundabout homolog 4, magic roundabout [Bos taurus]","gi|149642780|ref|NM_001099191.1|",3665,0,"Bos taurus roundabout guidance receptor 4 (ROBO4), mRNA","Q8WZ75",989,0,"Roundabout homolog 4",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0001525|angiogenesis;GO:0030154|cell differentiation;GO:0030334|regulation of cell migration;","GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;","GO:0038023|signaling receptor activity;","K06784","ROBO4; roundabout, axon guidance receptor 4"]
["gene32331",96,90,137,96.5900856691795,35,15,25,27.6110189026437,3.49824416149782,1.80663098631189,0.000609749802482235,0.0123820438538225,"up","yes","OPCML","protein_coding","chrNC_037356.1:33454438-34527270:+","gi|803268817|ref|XP_011994132.1|",1956,0,"PREDICTED: opioid-binding protein/cell adhesion molecule isoform X5 [Ovis aries musimon]","gi|965848086|ref|XM_012138742.2|",5490,0,"PREDICTED: Ovis aries musimon opioid binding protein/cell adhesion molecule-like (OPCML), transcript variant X5, mRNA","P11834",659,0,"Opioid-binding protein/cell adhesion molecule",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;","GO:0031225|anchored component of membrane;GO:0005886|plasma membrane;",".","K06773","OPCML, OBCAM; opioid binding protein/cell adhesion molecule-like"]
["gene32366",1940,4127,3862,3044.20369054234,1060,1226,1405,1353.28784345384,2.24948720648592,1.16959616189726,{"v":5.53210054190923e-06,"d":"5.53E-06"},0.000257902549936621,"up","yes","TMEM109","protein_coding","chrNC_037356.1:37252089-37260870:+","gi|555982218|ref|XP_005903016.1|",672,{"v":2e-79,"d":"2.00E-79"},"PREDICTED: transmembrane protein 109 [Bos mutus]","gi|114050780|ref|NM_001046470.1|",2002,0,"Bos taurus transmembrane protein 109 (TMEM109), mRNA","O77751",218,{"v":6e-64,"d":"6.00E-64"},"Transmembrane protein 109",".",".",".",".","pfam14965","BRI3BP","Negative regulator of p53/TP53. This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 213 and 245 amino acids in length. It is found in various tissues, including the brain, liver and kidneys. It was first discovered as a functional unknown gene, murine brain I3 (BRI3). This protein is also known as HCCRBP-1 and it plays a role in tumorigenesis, as it binds to an oncogene, HCCR-1, and acts as a negative regulator of p53/TP53 tumor suppressor. BRI3BP induces tumorigenesis by activating protein kinase C (PKC) activity but decreasing the pro-apoptotic PKC-alpha and PKC-delta isoform levels. BRI3BP is over-expressed in many tumors.","GO:0034765|regulation of ion transmembrane transport;","GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;GO:0005640|nuclear outer membrane;GO:0033017|sarcoplasmic reticulum membrane;","GO:0005244|voltage-gated ion channel activity;",".","."]
["gene32448",0,47,3,16.3240958235341,0,0,1,0.360972888453242,45.222498269835,5.49896878936388,{"v":7.9646568749638e-05,"d":"7.96E-05"},0.00240975212406779,"up","yes","PPP1R32","protein_coding","chrNC_037356.1:39953298-39962271:+","gi|529012181|ref|XP_005226945.1|",2460,0,"PREDICTED: protein phosphatase 1 regulatory subunit 32 isoform X1 [Bos taurus]","gi|982971686|ref|XM_005226888.3|",1689,0,"PREDICTED: Bos taurus protein phosphatase 1 regulatory subunit 32 (PPP1R32), transcript variant X1, mRNA","Q2T9T0",832,0,"Protein phosphatase 1 regulatory subunit 32",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.",".",".","GO:0019902|phosphatase binding;","K17571","PPP1R32; protein phosphatase 1 regulatory subunit 32"]
["gene32450",820,317,313,413.726629833519,116,147,152,152.172150147788,2.71880649272361,1.44297347320062,{"v":2.14655652807838e-06,"d":"2.15E-06"},0.000116876725768329,"up","yes","SYT7","protein_coding","chrNC_037356.1:39984090-40047328:-","gi|965863650|ref|XP_014964240.1|",3218,0,"PREDICTED: synaptotagmin-7 isoform X3 [Ovis aries musimon]","gi|982971802|ref|XM_010821033.2|",4759,0,"PREDICTED: Bos taurus synaptotagmin 7 (SYT7), transcript variant X1, mRNA","O43581",659,0,"Synaptotagmin-7","YOR086c",65.1,{"v":2e-09,"d":"2.00E-09"},"COG5038","pfam00168","C2","C2 domain.","GO:0048791|calcium ion-dependent exocytosis of neurotransmitter;GO:0006909|phagocytosis;GO:0090385|phagosome-lysosome fusion;GO:0001778|plasma membrane repair;GO:0045956|positive regulation of calcium ion-dependent exocytosis;GO:0046850|regulation of bone remodeling;GO:0017158|regulation of calcium ion-dependent exocytosis;GO:0014059|regulation of dopamine secretion;GO:0070092|regulation of glucagon secretion;GO:0050796|regulation of insulin secretion;GO:0050764|regulation of phagocytosis;GO:0036465|synaptic vesicle recycling;GO:0006906|vesicle fusion;GO:0090119|vesicle-mediated cholesterol transport;","GO:0043679|axon terminus;GO:0030054|cell junction;GO:0005829|cytosol;GO:0030425|dendrite;GO:0031045|dense core granule;GO:0032009|early phagosome;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0005765|lysosomal membrane;GO:0005764|lysosome;GO:0043025|neuronal cell body;GO:0005778|peroxisomal membrane;GO:0005777|peroxisome;GO:0030670|phagocytic vesicle membrane;GO:0005886|plasma membrane;GO:0042734|presynaptic membrane;GO:0008021|synaptic vesicle;GO:0030672|synaptic vesicle membrane;","GO:0005509|calcium ion binding;GO:0005544|calcium-dependent phospholipid binding;GO:0005516|calmodulin binding;GO:0030276|clathrin binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0001786|phosphatidylserine binding;GO:0019905|syntaxin binding;",".","."]
["gene32457",252,187,146,171.800020201141,71,81,70,81.5316296829987,2.1071579320702,1.07529844860022,0.00339674092279874,0.045222778939977,"up","yes","FADS1","protein_coding","chrNC_037356.1:40244825-40351549:-","gi|529012341|ref|XP_005227018.1|",2412,0,"PREDICTED: fatty acid desaturase 1 isoform X1 [Bos taurus]","gi|983009810|ref|XM_015470033.1|",3010,0,"PREDICTED: Bos taurus fatty acid desaturase 1 (FADS1), transcript variant X1, mRNA","O60427",697,0,"Fatty acid desaturase 1","sll0262",52.4,{"v":4e-06,"d":"4.00E-06"},"COG3239","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0036109|alpha-linolenic acid metabolic process;GO:0007267|cell-cell signaling;GO:0009267|cellular response to starvation;GO:0046456|icosanoid biosynthetic process;GO:0043651|linoleic acid metabolic process;GO:0008654|phospholipid biosynthetic process;GO:0045595|regulation of cell differentiation;GO:0019216|regulation of lipid metabolic process;GO:0006355|regulation of transcription, DNA-templated;GO:0006636|unsaturated fatty acid biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0016020|membrane;GO:0005739|mitochondrion;","GO:0000248|C-5 sterol desaturase activity;GO:0045485|omega-6 fatty acid desaturase activity;GO:0016491|oxidoreductase activity;","K10224","FADS1; fatty acid desaturase 1 (delta-5 desaturase) [EC:1.14.19.-]"]
["gene32458",695,429,315,418.467348567347,141,125,139,148.74997833475,2.81322628246452,1.49222560080751,{"v":6.08204044713875e-07,"d":"6.08E-07"},{"v":4.01682166660453e-05,"d":"4.02E-05"},"up","yes","FADS2","protein_coding","chrNC_037356.1:40257864-40387557:+","gi|134085894|ref|NP_001076913.1|",1910,0,"fatty acid desaturase 2 [Bos taurus]","gi|134085893|ref|NM_001083444.1|",2713,0,"Bos taurus fatty acid desaturase 2 (FADS2), mRNA","A4FV48",740,0,"Fatty acid desaturase 2","Rv3229c",53.1,{"v":3e-06,"d":"3.00E-06"},"COG3239","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006636|unsaturated fatty acid biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0004768|stearoyl-CoA 9-desaturase activity;","K10226","FADS2; fatty acid desaturase 2 (delta-6 desaturase) [EC:1.14.19.-]"]
["gene32460",2533,737,1561,1381.10345854363,445,367,479,473.917251520502,2.91422912779085,1.54311431203943,{"v":1.88701003182987e-09,"d":"1.89E-09"},{"v":2.29099077523991e-07,"d":"2.29E-07"},"up","yes","FADS3","protein_coding","chrNC_037356.1:40392814-40407832:-","gi|139948648|ref|NP_001077160.1|",2177,0,"fatty acid desaturase 3 [Bos taurus]","gi|402743542|ref|NM_001083691.2|",1090,0,"Bos taurus fatty acid desaturase 3 (FADS3), mRNA","A4IFP3",843,0,"Fatty acid desaturase 3","sll0262",60.5,{"v":4e-09,"d":"4.00E-09"},"COG3239","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:0006633|fatty acid biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0016491|oxidoreductase activity;","K10225","FADS3; fatty acid desaturase 3 (delta-6 desaturase) [EC:1.14.19.-]"]
["gene32479",1201,1683,2137,1520.8762925655,672,567,693,709.408319919354,2.14386588070801,1.10021465426129,{"v":1.41200182204377e-05,"d":"1.41E-05"},0.000573055817705984,"up","yes","B3GAT3","protein_coding","chrNC_037356.1:40959799-40964658:-","gi|529012163|ref|XP_005226936.1|",1470,0,"PREDICTED: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform X1 [Bos taurus]","gi|982971675|ref|XM_005226879.3|",1445,0,"PREDICTED: Bos taurus beta-1,3-glucuronyltransferase 3 (B3GAT3), transcript variant X1, mRNA","Q9WU47",462,{"v":2e-159,"d":"2.00E-159"},"Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3",".",".",".",".","pfam03360","Glyco_transf_43","Glycosyltransferase family 43.","GO:0050650|chondroitin sulfate proteoglycan biosynthetic process;GO:0050651|dermatan sulfate proteoglycan biosynthetic process;GO:0006024|glycosaminoglycan biosynthetic process;GO:0015012|heparan sulfate proteoglycan biosynthetic process;GO:0043085|positive regulation of catalytic activity;GO:0090316|positive regulation of intracellular protein transport;GO:0006486|protein glycosylation;","GO:0005801|cis-Golgi network;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0015018|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;GO:0015020|glucuronosyltransferase activity;GO:0046872|metal ion binding;GO:0072542|protein phosphatase activator activity;","K10158","B3GAT3; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [EC:2.4.1.135]"]
["gene3250",36,12,92,41.5702389685281,6,7,6,6.97735885475486,5.95787601496219,2.5747981010194,0.000148128131286158,0.00404038595958449,"up","yes","S100A12","protein_coding","chrNC_037330.1:17102238-17104176:+","gi|27807183|ref|NP_777076.1|",471,{"v":9e-57,"d":"9.00E-57"},"protein S100-A12 [Bos taurus]","gi|942097003|ref|XM_014482886.1|",677,0,"PREDICTED: Bos mutus S100 calcium binding protein A12 (S100A12), transcript variant X4, mRNA","P79105",186,{"v":3e-58,"d":"3.00E-58"},"Protein S100-A12",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0043303|mast cell degranulation;","GO:0005856|cytoskeleton;GO:0005576|extracellular region;GO:0042629|mast cell granule;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0008144|drug binding;",".","."]
["gene3251",25,18,109,45.890757209907,5,1,2,2.95777379682035,15.5153031848616,3.95561998376318,{"v":5.73393670826902e-06,"d":"5.73E-06"},0.00026471674469842,"up","yes","S100A9","protein_coding","chrNC_037330.1:17115128-17117961:-","gi|528942343|ref|XP_005203785.1|",520,{"v":9e-63,"d":"9.00E-63"},"PREDICTED: protein S100-A9 isoform X1 [Bos taurus]","gi|528942342|ref|XM_005203728.1|",735,0,"PREDICTED: Bos taurus S100 calcium binding protein A9 (S100A9), transcript variant X1, mRNA","P28783",204,{"v":4e-64,"d":"4.00E-64"},"Protein S100-A9",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0006919|activation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006915|apoptotic process;GO:0006914|autophagy;GO:0045087|innate immune response;GO:0002523|leukocyte migration involved in inflammatory response;GO:0070488|neutrophil aggregation;GO:0030593|neutrophil chemotaxis;GO:0050729|positive regulation of inflammatory response;GO:2001244|positive regulation of intrinsic apoptotic signaling pathway;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005576|extracellular region;GO:0005886|plasma membrane;","GO:0016209|antioxidant activity;GO:0050544|arachidonic acid binding;GO:0005509|calcium ion binding;GO:0008017|microtubule binding;GO:0050786|RAGE receptor binding;GO:0035662|Toll-like receptor 4 binding;GO:0008270|zinc ion binding;",".","."]
["gene32513",1177,6496,5548,4139.51841713999,1461,1173,1586,1549.05459927157,2.67228696721636,1.41807494192493,{"v":5.77405783018463e-08,"d":"5.77E-08"},{"v":5.16425216153598e-06,"d":"5.16E-06"},"up","yes","SLC3A2","protein_coding","chrNC_037356.1:41158503-41199498:+","gi|164448600|ref|NP_001019659.2|",2422,0,"4F2 cell-surface antigen heavy chain [Bos taurus]","gi|164448599|ref|NM_001024488.2|",2038,0,"Bos taurus solute carrier family 3 (amino acid transporter heavy chain), member 2 (SLC3A2), mRNA","P08195",713,0,"4F2 cell-surface antigen heavy chain","SP0342",67,{"v":9e-11,"d":"9.00E-11"},"COG0366","pfam00128","Alpha-amylase","Alpha amylase, catalytic domain. Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the active site, interrupted by a ~70 a.a. calcium-binding domain protruding between beta strand 3 and alpha helix 3, and a carboxyl-terminal Greek key beta-barrel domain.","GO:0006865|amino acid transport;GO:0006816|calcium ion transport;GO:0005975|carbohydrate metabolic process;GO:0016049|cell growth;GO:1903801|L-leucine import into cell;GO:0050900|leukocyte migration;GO:0043330|response to exogenous dsRNA;GO:0015827|tryptophan transport;","GO:0016324|apical plasma membrane;GO:0009986|cell surface;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0042470|melanosome;GO:0016020|membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0045296|cadherin binding;GO:0005432|calcium:sodium antiporter activity;GO:0003824|catalytic activity;GO:0003725|double-stranded RNA binding;GO:0015175|neutral amino acid transmembrane transporter activity;GO:0003723|RNA binding;","K06519","SLC3A2, MDU1; solute carrier family 3, member 2"]
["gene32564",0,29,0,9.50381269699116,0,1,0,0.366987568989444,25.8968245795391,4.69470330306147,0.00374934307974804,0.0485576520237364,"up","yes","CATSPERZ","protein_coding","chrNC_037356.1:42599239-42602893:+","gi|803224360|ref|XP_011972478.1|",993,{"v":1e-129,"d":"1.00E-129"},"PREDICTED: testis-expressed sequence 40 protein isoform X2 [Ovis aries musimon]","gi|965802497|ref|XM_012117088.2|",896,0,"PREDICTED: Ovis aries musimon testis expressed 40 (TEX40), transcript variant X2, mRNA","Q9NTU4",159,{"v":5e-44,"d":"5.00E-44"},"Cation channel sperm-associated protein subunit zeta",".",".",".",".","pfam04094","DUF390","Protein of unknown function (DUF390). This is a family of long proteins currently only found in the rice genome. They have no known function. However they may be some kind of transposable element.","GO:0030317|sperm motility;GO:0007140|male meiosis;GO:0048240|sperm capacitation;GO:0007283|spermatogenesis;","GO:0036128|CatSper complex;GO:0005737|cytoplasm;GO:0097228|sperm principal piece;",".",".","."]
["gene32610",138,454,678,392.978300629483,142,143,218,184.246380854551,2.13289563033376,1.09281337154633,0.00194110965038548,0.0301479583207121,"up","yes","CDC42EP2","protein_coding","chrNC_037356.1:43522992-43528897:+","gi|115496490|ref|NP_001068809.1|",920,{"v":2e-116,"d":"2.00E-116"},"cdc42 effector protein 2 [Bos taurus]","gi|115496489|ref|NM_001075341.1|",1431,0,"Bos taurus CDC42 effector protein 2 (CDC42EP2), mRNA","Q08DN6",358,{"v":8e-118,"d":"8.00E-118"},"Cdc42 effector protein 2",".",".",".",".","pfam14957","BORG_CEP","Cdc42 effector. The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organisation of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.","GO:0030036|actin cytoskeleton organization;GO:0071346|cellular response to interferon-gamma;GO:0030838|positive regulation of actin filament polymerization;GO:0031274|positive regulation of pseudopodium assembly;GO:0008360|regulation of cell shape;GO:0007266|Rho protein signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0012505|endomembrane system;GO:0015630|microtubule cytoskeleton;GO:0045335|phagocytic vesicle;GO:0005886|plasma membrane;","GO:0017049|GTP-Rho binding;GO:0005096|GTPase activator activity;GO:0001515|opioid peptide activity;",".","."]
["gene32712",541,1267,1031,872.857874933095,82,162,153,145.329821504796,6.00604793906177,2.58641599024149,{"v":1.77941227370222e-09,"d":"1.78E-09"},{"v":2.18829360262923e-07,"d":"2.19E-07"},"up","yes","CARNS1","protein_coding","chrNC_037356.1:45310460-45319498:+","gi|440899404|gb|ELR50707.1|",4293,0,"Carnosine synthase 1, partial [Bos mutus]","gi|983009965|ref|XM_015470080.1|",4214,0,"PREDICTED: Bos taurus carnosine synthase 1 (CARNS1), transcript variant X5, mRNA","A5YM72",1288,0,"Carnosine synthase 1","mlr6296",85.5,{"v":2e-16,"d":"2.00E-16"},"COG0439","pfam13535","ATP-grasp_4","ATP-grasp domain. This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.","GO:0035499|carnosine biosynthetic process;GO:0006548|histidine catabolic process;","GO:0005829|cytosol;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0047730|carnosine synthase activity;GO:0046872|metal ion binding;","K14755","CRNS1, ATPGD1; carnosine synthase [EC:6.3.2.11]"]
["gene32746",0,34,0,11.1424010930241,0,0,0,0,"Inf","Inf",0.000307236218583861,0.00715571963462543,"up","yes","TESMIN","protein_coding","chrNC_037356.1:46118488-46159248:-","gi|803191549|ref|XP_011957594.1|",2673,0,"PREDICTED: tesmin isoform X1 [Ovis aries]","gi|803225232|ref|XM_012117540.1|",2146,0,"PREDICTED: Ovis aries musimon metallothionein-like 5, testis-specific (tesmin) (MTL5), transcript variant X3, mRNA","Q9Y4I5",785,0,"Tesmin",".",".",".",".","pfam03638","TCR","Tesmin/TSO1-like CXC domain, cysteine-rich domain. This family includes proteins that have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C. The family includes Tesmin and TSO1. This family is called a CXC domain in.","GO:0030154|cell differentiation;GO:0006875|cellular metal ion homeostasis;GO:0007275|multicellular organismal development;GO:0010038|response to metal ion;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;",".","."]
["gene32755",100,117,167,115.694604963345,22,22,29,26.7648382669792,4.32263418927817,2.11191075072729,{"v":2.19003920395002e-06,"d":"2.19E-06"},0.000118565481077605,"up","yes","MRGPRF","protein_coding","chrNC_037356.1:46354537-46364118:-","gi|555994421|ref|XP_005908963.1|",1595,0,"PREDICTED: mas-related G-protein coupled receptor member F [Bos mutus]","gi|942094849|ref|XM_005908901.2|",2036,0,"PREDICTED: Bos mutus MAS-related GPR, member F (MRGPRF), mRNA","Q96AM1",541,0,"Mas-related G-protein coupled receptor member F",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.",".","GO:0005887|integral component of plasma membrane;GO:0031965|nuclear membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;","K08394","MRGPRF; Mas-related G protein-coupled receptor member F"]
["gene32803",12759,5516,7733,7507.95418998823,3010,2923,3410,3428.6641652382,2.18976074300546,1.13077324711593,{"v":1.17503433085231e-05,"d":"1.18E-05"},0.000493013301375693,"up","yes","IGF2","protein_coding","chrNC_037356.1:49395153-49422469:+","gi|594054535|ref|XP_006051530.1|",1452,0,"PREDICTED: insulin-like growth factor II isoform X1 [Bubalus bubalis]","gi|529013062|ref|XM_005227272.1|",4299,0,"PREDICTED: Bos taurus insulin like growth factor 2 (IGF2), transcript variant X3, mRNA","P07456",281,{"v":2e-85,"d":"2.00E-85"},"Insulin-like growth factor II",".",".",".",".","pfam08365","IGF2_C","Insulin-like growth factor II E-peptide. This domain is found at the C-terminal domain of the insulin-like growth factor II (IGF-2, also see pfam00049) in vertebrates and seems to represent the E-peptide.","GO:0009887|organ morphogenesis;GO:0001892|embryonic placenta development;GO:0060669|embryonic placenta morphogenesis;GO:0031017|exocrine pancreas development;GO:0006006|glucose metabolic process;GO:0001701|in utero embryonic development;GO:0038028|insulin receptor signaling pathway via phosphatidylinositol 3-kinase;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0001649|osteoblast differentiation;GO:0042104|positive regulation of activated T cell proliferation;GO:0051781|positive regulation of cell division;GO:0008284|positive regulation of cell proliferation;GO:2000467|positive regulation of glycogen (starch) synthase activity;GO:0045725|positive regulation of glycogen biosynthetic process;GO:0046628|positive regulation of insulin receptor signaling pathway;GO:0043410|positive regulation of MAPK cascade;GO:0045840|positive regulation of mitotic nuclear division;GO:0040018|positive regulation of multicellular organism growth;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051897|positive regulation of protein kinase B signaling;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0031056|regulation of histone modification;GO:0051147|regulation of muscle cell differentiation;GO:0032868|response to insulin;GO:0051146|striated muscle cell differentiation;","GO:0005615|extracellular space;","GO:0008083|growth factor activity;GO:0005179|hormone activity;GO:0005158|insulin receptor binding;GO:0005159|insulin-like growth factor receptor binding;GO:0005178|integrin binding;GO:0043539|protein serine/threonine kinase activator activity;","K13769","IGF2; insulin-like growth factor 2"]
["gene32807",286,1007,751,635.198295535879,179,110,173,169.721430434344,3.74259334198578,1.90403829820505,{"v":4.39341715226265e-08,"d":"4.39E-08"},{"v":4.03050111804519e-06,"d":"4.03E-06"},"up","yes","LOC112444916","protein_coding","chrNC_037356.1:49528955-49533114:+","gi|961726170|ref|XP_014923409.1|",174,{"v":2e-10,"d":"2.00E-10"},"PREDICTED: uncharacterized protein LOC106971164 [Acinonyx jubatus]","gi|744624421|ref|XR_838756.1|",332,{"v":2e-171,"d":"2.00E-171"},"PREDICTED: Camelus dromedarius uncharacterized LOC105106400 (LOC105106400), transcript variant X2, ncRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["gene32810",37278,143854,123298,94726.4952279771,7399,21668,15275,16231.2576152645,5.83605395671205,2.54499322162473,{"v":8.03965921991394e-05,"d":"8.04E-05"},0.00242986776698479,"up","yes","TNNT3","protein_coding","chrNC_037356.1:49579057-49594751:-","gi|529013085|ref|XP_005227340.1|",972,{"v":4e-127,"d":"4.00E-127"},"PREDICTED: troponin T, fast skeletal muscle isoform X7 [Bos taurus]","gi|741980488|ref|XM_005227283.2|",1108,0,"PREDICTED: Bos taurus troponin T type 3 (skeletal, fast) (TNNT3), transcript variant X7, mRNA","P02641",301,{"v":6e-99,"d":"6.00E-99"},"Troponin T, fast skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0006942|regulation of striated muscle contraction;","GO:0005861|troponin complex;",".",".","."]
["gene32811",1425,3816,2786,2477.59964757613,302,551,406,461.643106461035,5.36691572537377,2.42409323420005,{"v":1.83310185897096e-09,"d":"1.83E-09"},{"v":2.2350525272778e-07,"d":"2.24E-07"},"up","yes","PRR33","protein_coding","chrNC_037356.1:49595927-49601869:+","gi|982972448|ref|XP_002699494.4|",2232,0,"PREDICTED: basic proline-rich protein [Bos taurus]","gi|983010076|ref|XM_001256022.4|",2175,0,"PREDICTED: Bos taurus proline rich 33 (PRR33), mRNA",".",".",".",".",".",".",".",".","pfam15485","DUF4643","Domain of unknown function (DUF4643). This family of proteins is found in eukaryotes. Proteins in this family are typically between 254 and 462 amino acids in length.",".",".",".",".","."]
["gene32813",21832,82858,76521,56345.2124956335,4492,17145,10245,11669.135373638,4.82856790083387,2.27159536530883,0.00326811601880509,0.0439516955431084,"up","yes","TNNI2","protein_coding","chrNC_037356.1:49645742-49648340:-","gi|148744237|gb|AAI42169.1|",975,{"v":2e-131,"d":"2.00E-131"},"TNNI2 protein [Bos taurus]","gi|300797480|ref|NM_001192094.1|",720,0,"Bos taurus troponin I type 2 (skeletal, fast) (TNNI2), mRNA","P48788",334,{"v":4e-115,"d":"4.00E-115"},"Troponin I, fast skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0060048|cardiac muscle contraction;GO:0030049|muscle filament sliding;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006937|regulation of muscle contraction;GO:0003009|skeletal muscle contraction;","GO:0005829|cytosol;GO:0005634|nucleus;GO:0005861|troponin complex;","GO:0003779|actin binding;GO:0031014|troponin T binding;","K12043","TNNI2; troponin I, fast skeletal muscle"]
["gene32837",363,578,982,585.620497756111,266,244,281,290.400660477964,2.01659492369008,1.01192131683418,0.000499644986968202,0.0105517180778607,"up","yes","POLR2L","protein_coding","chrNC_037356.1:50530776-50535563:+","gi|926727728|ref|XP_013831559.1|",389,{"v":2e-45,"d":"2.00E-45"},"PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC5, partial [Capra hircus]","gi|165973961|ref|NM_001113726.1|",376,0,"Bos taurus polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa (POLR2L), mRNA","P62876",139,{"v":4e-42,"d":"4.00E-42"},"DNA-directed RNA polymerases I, II, and III subunit RPABC5","SPAC1B3.12c",110,{"v":2e-31,"d":"2.00E-31"},"COG1644","pfam01194","RNA_pol_N","RNA polymerases N / 8 kDa subunit.","GO:0006360|transcription from RNA polymerase I promoter;GO:0006366|transcription from RNA polymerase II promoter;GO:0006383|transcription from RNA polymerase III promoter;","GO:0005736|DNA-directed RNA polymerase I complex;GO:0005665|DNA-directed RNA polymerase II, core complex;GO:0005666|DNA-directed RNA polymerase III complex;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003899|DNA-directed RNA polymerase activity;GO:0008270|zinc ion binding;","K03007","RPB10, POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5"]
["gene32864",250,1056,1255,796.663328629381,322,326,395,382.575563469122,2.08236856898383,1.05822544115673,0.000175919911580048,0.00459631043707908,"up","yes","HRAS","protein_coding","chrNC_037356.1:50760603-50765201:+","gi|640782539|ref|XP_008046913.1|",780,{"v":2e-96,"d":"2.00E-96"},"PREDICTED: GTPase HRas isoform X4 [Tarsius syrichta]","gi|334278888|ref|NM_001242347.1|",941,0,"Bos taurus Harvey rat sarcoma viral oncogene homolog (HRAS), transcript variant 2, mRNA","P01115",287,{"v":1e-93,"d":"1.00E-93"},"Transforming protein p29","SPAC17H9.09c",186,{"v":1e-53,"d":"1.00E-53"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007165|signal transduction;","GO:0020002|host cell plasma membrane;GO:0016020|membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;",".","."]
["gene32889",25,14,12,14.7890880330948,0,2,1,1.09494802643213,13.5066575545916,3.75559879501183,0.00107390890969246,0.019102054303264,"up","yes","AGTR2","protein_coding","chrNC_037357.1:543318-547890:-","gi|119923188|ref|XP_001249374.1|",1825,0,"PREDICTED: type-2 angiotensin II receptor [Bos taurus]","gi|983010137|ref|XM_001249373.5|",3189,0,"PREDICTED: Bos taurus angiotensin II receptor type 2 (AGTR2), mRNA","P50052",663,0,"Type-2 angiotensin II receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0035932|aldosterone secretion;GO:0002033|vasodilation by angiotensin involved in regulation of systemic arterial blood pressure;GO:0001974|blood vessel remodeling;GO:0007420|brain development;GO:0002035|brain renin-angiotensin system;GO:0061049|cell growth involved in cardiac muscle cell development;GO:0007166|cell surface receptor signaling pathway;GO:0071549|cellular response to dexamethasone stimulus;GO:0006883|cellular sodium ion homeostasis;GO:0021695|cerebellar cortex development;GO:0042416|dopamine biosynthetic process;GO:0035640|exploration behavior;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007199|G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger;GO:0006954|inflammatory response;GO:0035556|intracellular signal transduction;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0030308|negative regulation of cell growth;GO:0048147|negative regulation of fibroblast proliferation;GO:0010459|negative regulation of heart rate;GO:0032304|negative regulation of icosanoid secretion;GO:0051387|negative regulation of neurotrophin TRK receptor signaling pathway;GO:0010700|negative regulation of norepinephrine secretion;GO:0007263|nitric oxide mediated signal transduction;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0008284|positive regulation of cell proliferation;GO:0050715|positive regulation of cytokine secretion;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:0072300|positive regulation of metanephric glomerulus development;GO:0045429|positive regulation of nitric oxide biosynthetic process;GO:0051000|positive regulation of nitric-oxide synthase activity;GO:0032516|positive regulation of phosphoprotein phosphatase activity;GO:0035815|positive regulation of renal sodium excretion;GO:0045893|positive regulation of transcription, DNA-templated;GO:0008217|regulation of blood pressure;GO:0035566|regulation of metanephros size;GO:0042306|regulation of protein import into nucleus;GO:0001991|regulation of systemic arterial blood pressure by circulatory renin-angiotensin;GO:0002018|renin-angiotensin regulation of aldosterone production;GO:0042311|vasodilation;","GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0004945|angiotensin type II receptor activity;GO:0017046|peptide hormone binding;GO:0048019|receptor antagonist activity;GO:0008134|transcription factor binding;","K04167","AGTR2; angiotensin II receptor type 2"]
["gene32939",29,1,5,9.42139971549723,0,1,0,0.366987568989444,25.6722584403621,4.68213831317659,0.00296801381107678,0.0409876098953687,"up","yes","LOC789808","pseudogene","chrNC_037357.1:4213768-4215255:+","gi|440913117|gb|ELR62612.1|",2054,0,"Oxysterol-binding protein-related protein 1 [Bos mutus]","gi|850496270|gb|CP011912.1|",1128,0,"Ovis canadensis canadensis isolate 43U chromosome X sequence","Q9BXW6",696,0,"Oxysterol-binding protein-related protein 1",".",".",".",".","pfam01237","Oxysterol_BP","Oxysterol-binding protein.","GO:0019886|antigen processing and presentation of exogenous peptide antigen via MHC class II;GO:0006699|bile acid biosynthetic process;GO:0008203|cholesterol metabolic process;GO:0016192|vesicle-mediated transport;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005770|late endosome;","GO:0015485|cholesterol binding;GO:0005543|phospholipid binding;GO:0015248|sterol transporter activity;",".","."]
["gene33118",124,268,380,236.851840166135,88,89,108,104.53855752928,2.26568881151622,1.17994972306832,0.000762150549792554,0.0147203108363679,"up","yes","LOC783730","protein_coding","chrNC_037357.1:18793700-18795117:-","gi|958665211|ref|XP_014695427.1|",647,{"v":3e-79,"d":"3.00E-79"},"PREDICTED: protein FAM127-like [Equus asinus]","gi|983010315|ref|XM_001250514.6|",1417,0,"PREDICTED: Bos taurus protein FAM127 (LOC783730), mRNA",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["gene33211",64,88,137,87.5947067320075,19,11,26,20.523752072181,4.26796749560905,2.09354918879069,{"v":2.36140986027588e-05,"d":"2.36E-05"},0.000867096328488176,"up","yes","AFF2","protein_coding","chrNC_037357.1:31117336-31651657:+","gi|529013885|ref|XP_005227648.1|",5418,0,"PREDICTED: AF4/FMR2 family member 2 isoform X2 [Bos taurus]","gi|982972882|ref|XM_005227591.3|",7347,0,"PREDICTED: Bos taurus AF4/FMR2 family member 2 (AFF2), transcript variant X2, mRNA","P51816",1813,0,"AF4/FMR2 family member 2",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.","GO:0007420|brain development;GO:0007611|learning or memory;GO:0006397|mRNA processing;GO:0010629|negative regulation of gene expression;GO:0035063|nuclear speck organization;GO:0010468|regulation of gene expression;GO:0043484|regulation of RNA splicing;GO:0008380|RNA splicing;","GO:0016607|nuclear speck;","GO:0002151|G-quadruplex RNA binding;","K15194","AFF2; AF4/FMR2 family member 2"]
["gene33320",115,324,427,267.293137849759,92,113,79,104.373117780623,2.56093852069811,1.35667261921863,{"v":7.77498282943882e-05,"d":"7.77E-05"},0.00236238589038039,"up","yes","PNCK","protein_coding","chrNC_037357.1:36891606-36895266:-","gi|741981732|ref|XP_010819873.1|",1722,0,"PREDICTED: calcium/calmodulin-dependent protein kinase type 1B isoform X2 [Bos taurus]","gi|982973103|ref|XM_010821571.2|",1602,0,"PREDICTED: Bos taurus pregnancy up-regulated nonubiquitous CaM kinase (PNCK), transcript variant X4, mRNA","Q9QYK9",621,0,"Calcium/calmodulin-dependent protein kinase type 1B",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0018105|peptidyl-serine phosphorylation;GO:0018107|peptidyl-threonine phosphorylation;","GO:0005737|cytoplasm;GO:0005622|intracellular;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0004683|calmodulin-dependent protein kinase activity;","K08795","PNCK; pregnancy upregulated non-ubiquitously expressed CaM kinase [EC:2.7.11.17]"]
["gene33325",773,2116,1580,1380.16455237634,360,588,487,526.13899970908,2.6231937817563,1.3913243869595,{"v":2.38740105531198e-05,"d":"2.39E-05"},0.000875513361299564,"up","yes","ABCD1","protein_coding","chrNC_037357.1:36956083-36971899:+","gi|114051285|ref|NP_001039655.1|",3800,0,"ATP-binding cassette sub-family D member 1 [Bos taurus]","gi|114051284|ref|NM_001046190.1|",3534,0,"Bos taurus ATP binding cassette subfamily D member 1 (ABCD1), mRNA","P33897",1319,0,"ATP-binding cassette sub-family D member 1","YPL147w",363,{"v":1e-107,"d":"1.00E-107"},"COG4178","pfam06472","ABC_membrane_2","ABC transporter transmembrane region 2. This domain covers the transmembrane of a small family of ABC transporters and shares sequence similarity with pfam00664. Mutations in this domain in human ABCD3 (PMP70) are believed responsible for Zellweger Syndrome-2; mutations in human ABCD1 (ALD) are responsible for recessive X-linked adrenoleukodystrophy. A Saccharomyces cerevisiae homolog is involved in the import of long-chain fatty acids.","GO:0036109|alpha-linolenic acid metabolic process;GO:0006635|fatty acid beta-oxidation;GO:0033540|fatty acid beta-oxidation using acyl-CoA oxidase;GO:0043651|linoleic acid metabolic process;GO:0042758|long-chain fatty acid catabolic process;GO:0015910|peroxisomal long-chain fatty acid import;GO:0015919|peroxisomal membrane transport;GO:0007031|peroxisome organization;GO:0055085|transmembrane transport;GO:0042760|very long-chain fatty acid catabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005779|integral component of peroxisomal membrane;GO:0016020|membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005778|peroxisomal membrane;GO:0005777|peroxisome;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0005324|long-chain fatty acid transporter activity;GO:0042803|protein homodimerization activity;GO:0005215|transporter activity;","K05675","ABCD1, ALD; ATP-binding cassette, subfamily D (ALD), member 1"]
["gene33339",68,66,41,51.9437339104296,11,19,12,15.4158874642721,3.36949358451237,1.75253177894048,0.00227022784393329,0.0337002448570555,"up","yes","TMEM187","protein_coding","chrNC_037357.1:37183241-37188624:+","gi|803203237|ref|XP_011962470.1|",1366,{"v":2e-172,"d":"2.00E-172"},"PREDICTED: transmembrane protein 187 isoform X1 [Ovis aries]","gi|982973078|ref|XM_010821560.2|",3632,0,"PREDICTED: Bos taurus transmembrane protein 187 (TMEM187), transcript variant X3, mRNA","Q0VCM2",486,{"v":1e-158,"d":"1.00E-158"},"Transmembrane protein 187",".",".",".",".","pfam15100","TMEM187","TMEM187 protein family. The function of this family, TMEM187, is not known, however it is predicted to be a multi-pass membrane protein. Members of this family are as yet uncharacterized. This protein family is also alternatively named ITBA1. This family of proteins are found in eukaryotes. Proteins in this family are typically between 239 and 267 amino acids in length.",".","GO:0016021|integral component of membrane;GO:0030133|transport vesicle;",".",".","."]
["gene33416",113,50,97,75.6271081828073,24,23,20,24.6306060202593,3.07045259546606,1.61845132957199,0.00103808876332556,0.0185807468672783,"up","yes","NAP1L3","protein_coding","chrNC_037357.1:42119246-42121083:-","gi|555957269|ref|XP_005911930.1|",2132,0,"PREDICTED: LOW QUALITY PROTEIN: nucleosome assembly protein 1-like 3 [Bos mutus]","gi|942041055|ref|XM_005911868.2|",1808,0,"PREDICTED: Bos mutus nucleosome assembly protein 1-like 3 (NAP1L3), mRNA","Q99457",512,{"v":2e-174,"d":"2.00E-174"},"Nucleosome assembly protein 1-like 3",".",".",".",".","pfam00956","NAP","Nucleosome assembly protein (NAP). NAP proteins are involved in moving histones into the nucleus, nucleosome assembly and chromatin fluidity. They affect the transcription of many genes.","GO:0006334|nucleosome assembly;","GO:0005634|nucleus;",".","K11281","NAP1L3, BNAP; nucleosome assembly protein 1-like 3"]
["gene3343",1951,4402,4720,3400.70326956511,1265,1712,1537,1655.91468174644,2.05367058282163,1.03820478601663,{"v":6.89922611424418e-05,"d":"6.90E-05"},0.00213019373641744,"up","yes","SEMA6C","protein_coding","chrNC_037330.1:19673315-19687020:+","gi|982916712|ref|XP_010801384.2|",4300,0,"PREDICTED: semaphorin-6C isoform X1 [Bos taurus]","gi|982978587|ref|XM_010826826.2|",4054,0,"PREDICTED: Bos taurus semaphorin 6C (SEMA6C), transcript variant X1, mRNA","Q9H3T2",1398,0,"Semaphorin-6C",".",".",".",".","pfam01403","Sema","Sema domain. The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and human plexin A-3.","GO:0007411|axon guidance;","GO:0005887|integral component of plasma membrane;",".","K06842","SEMA6; semaphorin 6"]
["gene3344",923,1012,1040,891.61203790932,289,494,342,412.763564995226,2.16010353995181,1.11110046655306,0.0023510749020393,0.0346122384056157,"up","yes","GABPB2","protein_coding","chrNC_037330.1:19693579-19719499:-","gi|742192715|ref|XP_010855839.1|",1883,0,"PREDICTED: GA-binding protein subunit beta-2 isoform X1 [Bison bison bison]","gi|850474981|gb|CP011886.1|",4840,0,"Ovis canadensis canadensis isolate 43U chromosome 1 sequence","Q0V8G2",729,0,"GA-binding protein subunit beta-2","PAE1861",80.9,{"v":3e-15,"d":"3.00E-15"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0044212|transcription regulatory region DNA binding;","K09454","GABPB; GA-binding protein transcription factor, beta"]
["gene33499",35,31,22,26.03773728405,4,2,3,3.31196616407815,7.86171596994479,2.97484424265362,0.00033614156618837,0.00767850682539663,"up","yes","BEX2","protein_coding","chrNC_037357.1:52012431-52014017:+","gi|594048115|ref|XP_006048462.1|",757,{"v":6e-98,"d":"6.00E-98"},"PREDICTED: protein BEX2 [Bubalus bubalis]","gi|116004392|ref|NM_001077087.1|",802,0,"Bos taurus brain expressed X-linked 2 (BEX2), mRNA","Q9BXY8",182,{"v":8e-56,"d":"8.00E-56"},"Protein BEX2",".",".",".",".","pfam04538","BEX","Brain expressed X-linked like family. This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.","GO:0006915|apoptotic process;GO:0007049|cell cycle;GO:0042981|regulation of apoptotic process;GO:0051726|regulation of cell cycle;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".",".","."]
["gene33539",192,506,290,304.930080897438,97,122,120,124.344734779035,2.45229588079712,1.29413305733456,0.00010289159705743,0.00296525268247023,"up","yes","NRK","protein_coding","chrNC_037357.1:54618417-54767142:+","gi|300793971|ref|NP_001178094.1|",7558,0,"nik-related protein kinase [Bos taurus]","gi|513788274|ref|NM_001191165.2|",8259,0,"Bos taurus Nik related kinase (NRK), mRNA","Q7Z2Y5",2476,0,"Nik-related protein kinase",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0007256|activation of JNKK activity;GO:0008285|negative regulation of cell proliferation;GO:0048812|neuron projection morphogenesis;GO:0007567|parturition;GO:0042981|regulation of apoptotic process;GO:0007346|regulation of mitotic cell cycle;GO:0060721|regulation of spongiotrophoblast cell proliferation;GO:0031098|stress-activated protein kinase signaling cascade;","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0008349|MAP kinase kinase kinase kinase activity;","K16313","NRK; Nik-related protein kinase [EC:2.7.11.1]"]
["gene33563",1060,3569,2714,2279.4131417471,834,903,958,988.924389149867,2.30494177993386,1.20473031036763,{"v":3.72548618262323e-06,"d":"3.73E-06"},0.000182632038275641,"up","yes","ATG4A","protein_coding","chrNC_037357.1:56766726-56799908:+","gi|555998381|ref|XP_005910902.1|",2064,0,"PREDICTED: cysteine protease ATG4A isoform X1 [Bos mutus]","gi|555998380|ref|XM_005910840.1|",1191,0,"PREDICTED: Bos mutus autophagy related 4A, cysteine peptidase (ATG4A), transcript variant X1, mRNA","Q6PZ05",797,0,"Cysteine protease ATG4A",".",".",".",".","pfam03416","Peptidase_C54","Peptidase family C54.","GO:0000045|autophagosome assembly;GO:0000422|mitophagy;GO:0044804|nucleophagy;GO:0006501|C-terminal protein lipidation;GO:0051697|protein delipidation;GO:0006612|protein targeting to membrane;","GO:0005829|cytosol;","GO:0004197|cysteine-type endopeptidase activity;","K08342","ATG4; cysteine protease ATG4 [EC:3.4.22.-]"]
["gene33564",141,31,117,82.8403555814581,25,20,36,29.6789776187277,2.79121325018908,1.48089235128949,0.00173725633340452,0.0278615292008794,"up","yes","COL4A6","protein_coding","chrNC_037357.1:56802025-57140016:-","gi|528928680|ref|XP_601826.4|",2288,0,"PREDICTED: collagen alpha-6(IV) chain isoform X1 [Bos taurus]","gi|983010871|ref|XM_601826.8|",6675,0,"PREDICTED: Bos taurus collagen type IV alpha 6 (COL4A6), transcript variant X1, mRNA","Q14031",643,0,"Collagen alpha-6(IV) chain",".",".",".",".","pfam01413","C4","C-terminal tandem repeated domain in type 4 procollagen. Duplicated domain in C-terminus of type 4 collagens. Mutations in alpha-5 collagen IV are associated with X-linked Alport syndrome.","GO:0007155|cell adhesion;GO:0030198|extracellular matrix organization;","GO:0005587|collagen type IV trimer;GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;","GO:0005201|extracellular matrix structural constituent;","K06237","COL4A; collagen, type IV, alpha"]
["gene33566",263,129,152,157.501980214005,36,72,57,60.4542108557306,2.60531033297037,1.38145523015114,0.0010893757331593,0.0192929727143191,"up","yes","COL4A5","protein_coding","chrNC_037357.1:57141311-57392487:+","gi|470655616|ref|XP_004330271.1|",1410,{"v":8e-171,"d":"8.00E-171"},"PREDICTED: collagen alpha-5(IV) chain-like, partial [Tursiops truncatus]","gi|555998374|ref|XM_005910837.1|",6427,0,"PREDICTED: Bos mutus collagen, type IV, alpha 5 (COL4A5), transcript variant X1, mRNA","P29400",554,{"v":4e-163,"d":"4.00E-163"},"Collagen alpha-5(IV) chain",".",".",".",".","pfam01413","C4","C-terminal tandem repeated domain in type 4 procollagen. Duplicated domain in C-terminus of type 4 collagens. Mutations in alpha-5 collagen IV are associated with X-linked Alport syndrome.","GO:0038063|collagen-activated tyrosine kinase receptor signaling pathway;GO:0030198|extracellular matrix organization;GO:0007528|neuromuscular junction development;","GO:0005605|basal lamina;GO:0005587|collagen type IV trimer;GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;GO:0031594|neuromuscular junction;","GO:0005201|extracellular matrix structural constituent;","K06237","COL4A; collagen, type IV, alpha"]
["gene33580",3016,2820,2649,2523.76874508846,1030,1229,1125,1242.10335468835,2.03185084040102,1.02279449673988,{"v":3.82646419414746e-05,"d":"3.83E-05"},0.00129198638962392,"up","yes","TMEM164","protein_coding","chrNC_037357.1:58422954-58602846:+","gi|803204325|ref|XP_011962940.1|",920,{"v":6e-110,"d":"6.00E-110"},"PREDICTED: transmembrane protein 164 isoform X3 [Ovis aries]","gi|982973413|ref|XM_015461580.1|",4920,0,"PREDICTED: Bos taurus transmembrane protein 164 (TMEM164), transcript variant X9, mRNA","Q5U3C3",337,{"v":3e-102,"d":"3.00E-102"},"Transmembrane protein 164",".",".",".",".","pfam14808","TMEM164","TMEM164 family. This family of proteins is found in eukaryotes. Proteins in this family are typically between 214 and 330 amino acids in length. There are two conserved sequence motifs: LNPCH and DPF.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene33681",6250,12389,12332,9476.4135435719,4154,3711,4005,4360.21993340307,2.1733797121045,1.11994025041123,{"v":4.64456636956838e-05,"d":"4.64E-05"},0.00150927247255302,"up","yes","PGK1","protein_coding","chrNC_037357.1:74244892-74267571:-","gi|594054677|ref|XP_006051590.1|",2186,0,"PREDICTED: phosphoglycerate kinase 1 [Bubalus bubalis]","gi|942035043|ref|XM_005888671.2|",1808,0,"PREDICTED: Bos mutus phosphoglycerate kinase 1 (PGK1), mRNA","Q3T0P6",846,0,"Phosphoglycerate kinase 1","SPBC14F5.04c",566,0,"COG0126","pfam00162","PGK","Phosphoglycerate kinase.","GO:0071456|cellular response to hypoxia;GO:0030855|epithelial cell differentiation;GO:0006096|glycolytic process;GO:0016525|negative regulation of angiogenesis;GO:0031639|plasminogen activation;","GO:0005737|cytoplasm;GO:0005615|extracellular space;GO:0045121|membrane raft;","GO:0005524|ATP binding;GO:0004618|phosphoglycerate kinase activity;GO:0047134|protein-disulfide reductase activity;","K00927","PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]"]
["gene33736",13841,36515,24672,23151.2022216578,4632,8134,5789,6806.04273115234,3.40156580500017,1.76619899904049,{"v":8.36824770463869e-06,"d":"8.37E-06"},0.000373053867595385,"up","yes","PHKA1","protein_coding","chrNC_037357.1:77921419-78095264:+","gi|529014929|ref|XP_005228049.1|",6446,0,"PREDICTED: phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [Bos taurus]","gi|983011056|ref|XM_015470415.1|",4435,0,"PREDICTED: Bos taurus phosphorylase kinase, alpha 1 (muscle) (PHKA1), transcript variant X1, mRNA","P46020",2348,0,"Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform",".",".",".",".","pfam00723","Glyco_hydro_15","Glycosyl hydrolases family 15. In higher organisms this family is represented by phosphorylase kinase subunits.","GO:0006091|generation of precursor metabolites and energy;GO:0005977|glycogen metabolic process;","GO:0005829|cytosol;GO:0005964|phosphorylase kinase complex;GO:0005886|plasma membrane;","GO:0005516|calmodulin binding;GO:0004689|phosphorylase kinase activity;","K07190","PHKA_B; phosphorylase kinase alpha/beta subunit"]
["gene33808",632,1293,1003,896.495843403535,269,315,269,313.246407485331,2.86195091781065,1.51699893019234,{"v":1.91861258372297e-08,"d":"1.92E-08"},{"v":1.8941154195917e-06,"d":"1.89E-06"},"up","yes","AR","protein_coding","chrNC_037357.1:83085618-83296175:-","gi|346421335|ref|NP_001231056.1|",2524,0,"androgen receptor [Bos taurus]","gi|926728697|ref|XM_013976419.1|",2779,0,"PREDICTED: Capra hircus androgen receptor (AR), mRNA","Q9TT90",842,0,"Androgen receptor",".",".",".",".","pfam02166","Androgen_recep","Androgen receptor.","GO:0030521|androgen receptor signaling pathway;GO:0030522|intracellular receptor signaling pathway;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:0045720|negative regulation of integrin biosynthetic process;GO:0008284|positive regulation of cell proliferation;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0042327|positive regulation of phosphorylation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:1903076|regulation of protein localization to plasma membrane;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0000790|nuclear chromatin;GO:0005634|nucleus;","GO:0005497|androgen binding;GO:0004882|androgen receptor activity;GO:0008013|beta-catenin binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0004879|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0005496|steroid binding;GO:0044212|transcription regulatory region DNA binding;GO:0008270|zinc ion binding;","K08557","NR3C4, AR; androgen receptor"]
["gene33812",67,91,155,94.8879188850818,15,39,27,29.6653045315991,3.19861603928617,1.6774478222555,0.00320075926704954,0.0432800296910855,"up","yes","EDA2R","protein_coding","chrNC_037357.1:84364049-84453213:+","gi|529015078|ref|XP_005228114.1|",1489,0,"PREDICTED: tumor necrosis factor receptor superfamily member 27 isoform X1 [Bos taurus]","gi|983011118|ref|XM_015470435.1|",1281,0,"PREDICTED: Bos taurus ectodysplasin A2 receptor (EDA2R), transcript variant X2, mRNA","Q9HAV5",489,{"v":2e-171,"d":"2.00E-171"},"Tumor necrosis factor receptor superfamily member 27",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0010668|ectodermal cell differentiation;GO:0008544|epidermis development;GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;GO:0007275|multicellular organismal development;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0046330|positive regulation of JNK cascade;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0009888|tissue development;GO:0033209|tumor necrosis factor-mediated signaling pathway;","GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0038023|signaling receptor activity;GO:0005031|tumor necrosis factor-activated receptor activity;","K05163","EDA2R, TNFRSF27, XEDAR; tumor necrosis factor receptor superfamily member 27"]
["gene3383",3583,4769,3430,3550.12587299617,229,380,325,342.364357615631,10.3694376883176,3.37426575699691,{"v":4.39107799766262e-26,"d":"4.39E-26"},{"v":7.83011539695701e-23,"d":"7.83E-23"},"up","yes","CA14","protein_coding","chrNC_037330.1:20376430-20383671:-","gi|528942681|ref|XP_005203925.1|",1494,0,"PREDICTED: carbonic anhydrase 14 isoform X2 [Bos taurus]","gi|982916586|ref|XM_005203868.3|",2389,0,"PREDICTED: Bos taurus carbonic anhydrase XIV (CA14), transcript variant X2, mRNA","Q9ULX7",493,{"v":9e-167,"d":"9.00E-167"},"Carbonic anhydrase 14","BH0360",90.5,{"v":8e-19,"d":"8.00E-19"},"COG3338","pfam00194","Carb_anhydrase","Eukaryotic-type carbonic anhydrase.","GO:0015701|bicarbonate transport;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004089|carbonate dehydratase activity;GO:0008270|zinc ion binding;","K01672","E4.2.1.1; carbonic anhydrase [EC:4.2.1.1]"]
["gene33861",166,360,391,281.326380569952,73,135,98,112.203735465489,2.50728177099309,1.32612413688647,0.00115129642687381,0.0201642961050562,"up","yes","EBP","protein_coding","chrNC_037357.1:86657966-86662086:+","gi|77735949|ref|NP_001029672.1|",1213,{"v":8e-165,"d":"8.00E-165"},"3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [Bos taurus]","gi|982973913|ref|XM_010821901.2|",1117,0,"PREDICTED: Bos taurus emopamil binding protein (sterol isomerase) (EBP), transcript variant X1, mRNA","Q15125",397,{"v":3e-137,"d":"3.00E-137"},"3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase",".",".",".",".","pfam05241","EBP","Emopamil binding protein. Emopamil binding protein (EBP) is as a gene that encodes a non-glycosylated type I integral membrane protein of endoplasmic reticulum and shows high level expression in epithelial tissues. The EBP protein has emopamil binding domains, including the sterol acceptor site and the catalytic centre, which show Delta8-Delta7 sterol isomerase activity. Human sterol isomerase, a homologue of mouse EBP, is suggested not only to play a role in cholesterol biosynthesis, but also to affect lipoprotein internalisation. In humans, mutations of EBP are known to cause the genetic disorder of X-linked dominant chondrodysplasia punctata (CDPX2). This syndrome of humans is lethal in most males, and affected females display asymmetric hyperkeratotic skin and skeletal abnormalities.","GO:0006695|cholesterol biosynthetic process;GO:0033489|cholesterol biosynthetic process via desmosterol;GO:0033490|cholesterol biosynthetic process via lathosterol;GO:0008203|cholesterol metabolic process;GO:0030097|hemopoiesis;GO:0001501|skeletal system development;","GO:0031410|cytoplasmic vesicle;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005887|integral component of plasma membrane;GO:0005635|nuclear envelope;","GO:0000247|C-8 sterol isomerase activity;GO:0047750|cholestenol delta-isomerase activity;GO:0015238|drug transmembrane transporter activity;GO:0004769|steroid delta-isomerase activity;GO:0004888|transmembrane signaling receptor activity;","K01824","EBP; cholestenol delta-isomerase [EC:5.3.3.5]"]
["gene33926",6048,1829,2716,3009.78732853387,1265,1460,1326,1487.26853489747,2.02370134102336,1.01699639199999,{"v":7.66967938288503e-05,"d":"7.67E-05"},0.00233536416726887,"up","yes","SHROOM4","protein_coding","chrNC_037357.1:88411763-88674152:-","gi|741982988|ref|XP_010820251.1|",7509,0,"PREDICTED: protein Shroom4 isoform X1 [Bos taurus]","gi|983011245|ref|XM_010800493.2|",8602,0,"PREDICTED: Bos taurus shroom family member 4 (SHROOM4), transcript variant X1, mRNA","Q9ULL8",2311,0,"Protein Shroom4",".",".",".",".","pfam08687","ASD2","Apx/Shroom domain ASD2. This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.","GO:0030036|actin cytoskeleton organization;GO:0007015|actin filament organization;GO:0007420|brain development;GO:0050890|cognition;","GO:0016324|apical plasma membrane;GO:0009925|basal plasma membrane;GO:0030864|cortical actin cytoskeleton;GO:0005737|cytoplasm;GO:0009898|cytoplasmic side of plasma membrane;GO:0016460|myosin II complex;GO:0001725|stress fiber;","GO:0051015|actin filament binding;","K18625","SHROOM; protein Shroom"]
["gene34067",253,782,960,617.049672322894,178,270,251,256.221558681823,2.40826601593329,1.26799476031643,{"v":1.33431566589585e-05,"d":"1.33E-05"},0.000545406307502498,"up","yes","MAOB","protein_coding","chrNC_037357.1:99790477-99912396:+","gi|113205963|ref|NP_808813.2|",2711,0,"amine oxidase [flavin-containing] B [Bos taurus]","gi|113205962|ref|NM_177944.2|",2465,0,"Bos taurus monoamine oxidase B (MAOB), mRNA","P56560",1031,0,"Amine oxidase [flavin-containing] B","MT3259",240,{"v":2e-69,"d":"2.00E-69"},"COG1231","pfam01593","Amino_oxidase","Flavin containing amine oxidoreductase. This family consists of various amine oxidases, including maze polyamine oxidase (PAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.",".","GO:0016021|integral component of membrane;GO:0005741|mitochondrial outer membrane;","GO:0016491|oxidoreductase activity;","K00274","MAO, aofH; monoamine oxidase [EC:1.4.3.4]"]
["gene34120",168,38,83,81.7290711878065,30,19,31,29.3759660583965,2.78217475555824,1.47621304211557,0.00175547375710185,0.0280433492518885,"up","yes","LANCL3","protein_coding","chrNC_037357.1:105734791-105847786:-","gi|803327634|ref|XP_012021978.1|",2301,0,"PREDICTED: lanC-like protein 3 isoform X2 [Ovis aries musimon]","gi|330417874|ref|NM_001206408.1|",2027,0,"Bos taurus LanC like 3 (LANCL3), mRNA","Q6ZV70",798,0,"LanC-like protein 3",".",".",".",".","pfam05147","LANC_like","Lanthionine synthetase C-like protein. Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains. This region contains seven internal repeats.","GO:0007165|signal transduction;","GO:0005886|plasma membrane;","GO:0003824|catalytic activity;",".","."]
["gene34127",465,337,417,359.700384236038,165,145,140,165.421136767429,2.17445237812476,1.12065211321883,0.000250011830605294,0.00601475754179149,"up","yes","PRRG1","protein_coding","chrNC_037357.1:106059230-106203099:+","gi|594085943|ref|XP_006066488.1|",1043,{"v":1e-127,"d":"1.00E-127"},"PREDICTED: transmembrane gamma-carboxyglutamic acid protein 1-like isoform X2 [Bubalus bubalis]","gi|157785642|ref|NM_001105640.1|",4414,0,"Bos taurus proline rich Gla (G-carboxyglutamic acid) 1 (PRRG1), mRNA","A7Z070",380,{"v":6e-120,"d":"6.00E-120"},"Transmembrane gamma-carboxyglutamic acid protein 1",".",".",".",".","pfam00594","Gla","Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain. This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).",".","GO:0005576|extracellular region;GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;",".","."]
["gene34175",0,9,28,11.5488648538862,0,0,0,0,"Inf","Inf",0.000194446809994472,0.00495335887138595,"up","yes","LOC526966","protein_coding","chrNC_037357.1:113494123-113498088:-","gi|982974482|ref|XP_015317236.1|",1307,{"v":1e-172,"d":"1.00E-172"},"PREDICTED: melanoma-associated antigen B2 [Bos taurus]","gi|983011568|ref|XM_015470536.1|",1587,0,"PREDICTED: Bos taurus melanoma-associated antigen B2 (LOC526966), mRNA",".",".",".",".",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.",".",".",".",".","."]
["gene34246",8610,9150,11053,8637.19825017044,3446,3801,3408,3913.12019235464,2.20724072494517,1.14224398065776,{"v":1.63356333040642e-05,"d":"1.63E-05"},0.000642857867307939,"up","yes","RPS6KA3","protein_coding","chrNC_037357.1:122901808-123061018:+","gi|537132932|gb|ERE65852.1|",3751,0,"ribosomal protein S6 kinase alpha-3 [Cricetulus griseus]","gi|982974583|ref|XM_005228374.3|",7770,0,"PREDICTED: Bos taurus ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3), transcript variant X1, mRNA","P18654",1429,0,"Ribosomal protein S6 kinase alpha-3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0007049|cell cycle;GO:0035556|intracellular signal transduction;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0032496|response to lipopolysaccharide;GO:0002224|toll-like receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0043027|cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0000287|magnesium ion binding;GO:0019901|protein kinase binding;GO:0004674|protein serine/threonine kinase activity;","K04373","RPS6KA, RSK2; p90 ribosomal S6 kinase [EC:2.7.11.1]"]
["gene34254",17192,23997,17898,17841.7388339265,5311,6728,5659,6496.92026688979,2.74618405352044,1.4574283203877,{"v":4.65513845407524e-07,"d":"4.66E-07"},{"v":3.1603443733994e-05,"d":"3.16E-05"},"up","yes","PDHA1","protein_coding","chrNC_037357.1:123763235-123786122:-","gi|155371825|ref|NP_001094516.1|",2025,0,"pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor [Bos taurus]","gi|402691728|ref|NM_001101046.2|",4162,0,"Bos taurus pyruvate dehydrogenase (lipoamide) alpha 1 (PDHA1), mRNA","A7MB35",784,0,"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial","YER178w",365,{"v":6e-112,"d":"6.00E-112"},"COG1071","pfam00676","E1_dh","Dehydrogenase E1 component. This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase.","GO:0006086|acetyl-CoA biosynthetic process from pyruvate;GO:0006006|glucose metabolic process;GO:0061732|mitochondrial acetyl-CoA biosynthetic process from pyruvate;GO:0006099|tricarboxylic acid cycle;","GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;GO:0043209|myelin sheath;GO:0005730|nucleolus;GO:0045254|pyruvate dehydrogenase complex;","GO:0004739|pyruvate dehydrogenase (acetyl-transferring) activity;GO:0034604|pyruvate dehydrogenase (NAD+) activity;GO:0004738|pyruvate dehydrogenase activity;","K00161","PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]"]
["gene34278",309,401,393,332.646171552217,96,102,96,107.967865986183,3.08097384822616,1.62338643661467,{"v":3.75190893775461e-07,"d":"3.75E-07"},{"v":2.61087107080675e-05,"d":"2.61E-05"},"up","yes","CDKL5","protein_coding","chrNC_037357.1:124822431-125001076:-","gi|555955835|ref|XP_005890072.1|",4905,0,"PREDICTED: cyclin-dependent kinase-like 5 [Bos mutus]","gi|555955834|ref|XM_005890010.1|",3040,0,"PREDICTED: Bos mutus cyclin-dependent kinase-like 5 (CDKL5), mRNA","O76039",1715,0,"Cyclin-dependent kinase-like 5",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001764|neuron migration;GO:0045773|positive regulation of axon extension;GO:0050775|positive regulation of dendrite morphogenesis;GO:0060999|positive regulation of dendritic spine development;GO:0043547|positive regulation of GTPase activity;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:1902017|regulation of cilium assembly;GO:0050773|regulation of dendrite development;","GO:0005813|centrosome;GO:0036064|ciliary basal body;GO:0097542|ciliary tip;GO:0005829|cytosol;GO:0032839|dendrite cytoplasm;GO:0044294|dendritic growth cone;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0032587|ruffle membrane;GO:0045202|synapse;","GO:0005524|ATP binding;GO:0016301|kinase activity;GO:0004672|protein kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0048365|Rac GTPase binding;","K08824","CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]"]
["gene34291",85,87,144,94.8899284616181,11,14,20,16.4687327269508,5.76182333121068,2.52652542532011,{"v":2.88450615963516e-07,"d":"2.88E-07"},{"v":2.07822841516542e-05,"d":"2.08E-05"},"up","yes","REPS2","protein_coding","chrNC_037357.1:126288880-126533816:-","gi|803282662|ref|XP_012001024.1|",2811,0,"PREDICTED: ralBP1-associated Eps domain-containing protein 2 isoform X13 [Ovis aries musimon]","gi|983011745|ref|XM_015470584.1|",7075,0,"PREDICTED: Bos taurus RALBP1 associated Eps domain containing 2 (REPS2), transcript variant X3, mRNA","Q8NFH8",1023,0,"RalBP1-associated Eps domain-containing protein 2",".",".",".",".","pfam12763","EF-hand_4","Cytoskeletal-regulatory complex EF hand. This is an efhand family from the N-terminal of actin cytoskeleton-regulatory complex END3 and similar proteins from fungi and closely related species.","GO:0007173|epidermal growth factor receptor signaling pathway;GO:0061024|membrane organization;GO:0065003|macromolecular complex assembly;","GO:0005829|cytosol;","GO:0005509|calcium ion binding;",".","."]
["gene34315",243,58,123,120.115032878978,37,38,35,40.408998054303,2.97248233469098,1.57166823613428,0.000179345469339754,0.00464329000520191,"up","yes","BMX","protein_coding","chrNC_037357.1:127953853-128000226:-","gi|529016022|ref|XP_005228505.1|",3483,0,"PREDICTED: cytoplasmic tyrosine-protein kinase BMX isoform X1 [Bos taurus]","gi|982974699|ref|XM_005228448.3|",3383,0,"PREDICTED: Bos taurus BMX non-receptor tyrosine kinase (BMX), transcript variant X1, mRNA","P51813",1214,0,"Cytoplasmic tyrosine-protein kinase BMX",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006915|apoptotic process;GO:0007155|cell adhesion;GO:0045087|innate immune response;GO:0035556|intracellular signal transduction;GO:0007498|mesoderm development;GO:0001865|NK T cell differentiation;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0006661|phosphatidylinositol biosynthetic process;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0042127|regulation of cell proliferation;GO:0007165|signal transduction;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;","GO:0005829|cytosol;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0032587|ruffle membrane;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0004713|protein tyrosine kinase activity;","K08896","BMX, ETK; cytoplasmic tyrosine-protein kinase BMX [EC:2.7.10.2]"]
["gene34320",1285,2236,1938,1662.87931597297,266,489,384,417.492822391062,3.98301294486774,1.99386016849601,{"v":1.27952459363735e-07,"d":"1.28E-07"},{"v":1.03416759719738e-05,"d":"1.03E-05"},"up","yes","ASB11","protein_coding","chrNC_037357.1:128175604-128207823:+","gi|741983765|ref|XP_010820489.1|",1637,0,"PREDICTED: ankyrin repeat and SOCS box protein 11 isoform X1 [Bos taurus]","gi|982974675|ref|XM_010822188.2|",1774,0,"PREDICTED: Bos taurus ankyrin repeat and SOCS box containing 11 (ASB11), transcript variant X3, mRNA","Q3SZE4",608,0,"Ankyrin repeat and SOCS box protein 11","alr7243_1",73.9,{"v":3e-13,"d":"3.00E-13"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0035556|intracellular signal transduction;GO:0016567|protein ubiquitination;","GO:0005622|intracellular;",".","K10333","ASB11; ankyrin repeat and SOCS box protein 11"]
["gene34345",1,19,16,11.4012052794911,0,0,0,0,"Inf","Inf",0.000214879172306411,0.00533240697670016,"up","yes","LOC112445119","protein_coding","chrNC_037357.1:130157656-130168476:+","gi|296470438|tpg|DAA12553.1|",2031,0,"TPA: TFIIS central domain-containing protein 1-like [Bos taurus]","gi|982974662|ref|XM_015461784.1|",1031,0,"PREDICTED: Bos taurus transcription elongation factor A (SII) N-terminal and central domain containing (TCEANC), transcript variant X1, mRNA","Q8N8B7",478,{"v":7e-165,"d":"7.00E-165"},"Transcription elongation factor A N-terminal and central domain-containing protein","ECU04g0180",64.3,{"v":1e-10,"d":"1.00E-10"},"COG1594","pfam07500","TFIIS_M","Transcription factor S-II (TFIIS), central domain. Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and pfam01096 are required for transcription activity.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;",".",".","."]
["gene34385",1350,422,455,629.878573645753,156,122,145,155.421374311274,4.05271524870349,2.018888812514,{"v":2.8603761319572e-12,"d":"2.86E-12"},{"v":6.63490987161552e-10,"d":"6.63E-10"},"up","yes","ANOS1","protein_coding","chrNC_037357.1:134225253-134436096:+","gi|529016240|ref|XP_005228592.1|",3241,0,"PREDICTED: anosmin-1 [Bos taurus]","gi|965822690|ref|XM_012126975.2|",4496,0,"PREDICTED: Ovis aries musimon anosmin 1 (ANOS1), transcript variant X2, mRNA","P23352",1031,0,"Anosmin-1",".",".",".",".","pfam00095","WAP","WAP-type (Whey Acidic Protein) 'four-disulfide core'.","GO:0007411|axon guidance;GO:0007155|cell adhesion;GO:0006935|chemotaxis;GO:0008543|fibroblast growth factor receptor signaling pathway;","GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005886|plasma membrane;","GO:0005201|extracellular matrix structural constituent;GO:0008201|heparin binding;GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["gene34444",41,26,31,28.7269830115072,0,0,0,0,"Inf","Inf",{"v":5.56436673832748e-09,"d":"5.56E-09"},{"v":6.12961186915912e-07,"d":"6.13E-07"},"up","yes","LOC112445398","pseudogene","chrNW_020190209.1:32321-45392:-","gi|119573588|gb|EAW53203.1|",450,{"v":6e-50,"d":"6.00E-50"},"hCG1997137, isoform CRA_b [Homo sapiens]","gi|258597991|gb|GQ452383.1|",456,0,"Bubalus bubalis ribosomal protein SA pseudogene, complete sequence","Q4GWZ2",150,{"v":3e-40,"d":"3.00E-40"},"40S ribosomal protein SA","SPAPJ698.02c",80.1,{"v":8e-30,"d":"8.00E-30"},"COG0052","pfam07919","Gryzun","Gryzun, putative trafficking through Golgi. The proteins featured in this family are all eukaryotic, and many of them are annotated as being Gryzun. Gryzun is distantly related to, but distinct from, the Trs130 subunit of the TRAPP complex but is absent from S. cerevisiae. RNAi of human Gryzun blocks Golgi exit. Thus the family is likely to be involved with trafficking of proteins through membranes, perhaps as part of the TRAPP complex.","GO:0000447|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000461|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000028|ribosomal small subunit assembly;GO:0006407|rRNA export from nucleus;GO:0006412|translation;","GO:0030686|90S preribosome;GO:0098556|cytoplasmic side of rough endoplasmic reticulum membrane;GO:0022627|cytosolic small ribosomal subunit;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005055|laminin receptor activity;GO:0003735|structural constituent of ribosome;GO:0001618|virus receptor activity;","K02998","RP-SAe, RPSA; small subunit ribosomal protein SAe"]
["gene34567",116,70,70,74.6710473700291,10,3,6,7.00448093953662,10.6604683508452,3.41419891690556,{"v":1.25065538519411e-07,"d":"1.25E-07"},{"v":1.01949853699923e-05,"d":"1.02E-05"},"up","yes","LOC783508","protein_coding","chrNW_020190651.1:24629-36583:-","gi|440895103|gb|ELR47376.1|",1353,0,"hypothetical protein M91_11428, partial [Bos mutus]","gi|332078502|ref|NM_001206746.1|",1374,0,"Bos taurus UL16-binding protein 27-like (LOC783508), mRNA","Q9BZM4",201,{"v":1e-59,"d":"1.00E-59"},"UL16-binding protein 3",".",".",".",".","pfam14586","MHC_I_2","Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2. Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.","GO:0030101|natural killer cell activation;GO:0042267|natural killer cell mediated cytotoxicity;GO:0050776|regulation of immune response;GO:0016032|viral process;","GO:0046658|anchored component of plasma membrane;GO:0005886|plasma membrane;","GO:0046703|natural killer cell lectin-like receptor binding;","K07986","ULBP; UL16 binding protein"]
["gene34587",13,26,60,30.3360597547282,0,1,1,0.727960457442686,41.6726752731849,5.3810298150254,{"v":1.31420644644766e-07,"d":"1.31E-07"},{"v":1.05919842157057e-05,"d":"1.06E-05"},"up","yes","ULBP27","protein_coding","chrNW_020190741.1:279-6918:+","gi|274317280|ref|NP_001162087.1|",1206,{"v":3e-163,"d":"3.00E-163"},"UL16-binding protein 27 precursor [Bos taurus]","gi|274317279|ref|NM_001168616.1|",1158,0,"Bos taurus UL16-binding protein 27 (ULBP27), mRNA","Q9BZM4",192,{"v":1e-56,"d":"1.00E-56"},"UL16-binding protein 3",".",".",".",".","pfam14586","MHC_I_2","Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2. Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.","GO:0030101|natural killer cell activation;GO:0042267|natural killer cell mediated cytotoxicity;GO:0050776|regulation of immune response;GO:0016032|viral process;","GO:0046658|anchored component of plasma membrane;GO:0005886|plasma membrane;","GO:0046703|natural killer cell lectin-like receptor binding;","K07986","ULBP; UL16 binding protein"]
["gene34594",4515,1432,1193,2012.4017398338,242,244,291,285.03995519806,7.06006895922883,2.81968227509016,{"v":3.92886815348316e-28,"d":"3.93E-28"},{"v":8.62265671438678e-25,"d":"8.62E-25"},"up","yes","ULBP13","protein_coding","chrNW_020190741.1:42571-102514:+","gi|274321350|ref|NP_001162075.1|",1397,0,"UL16 binding protein 13 precursor [Bos taurus]","gi|274321349|ref|NM_001168604.1|",1315,0,"Bos taurus UL16 binding protein 13 (ULBP13), mRNA","Q9BZM4",194,{"v":6e-57,"d":"6.00E-57"},"UL16-binding protein 3",".",".",".",".","pfam00129","MHC_I","Class I Histocompatibility antigen, domains alpha 1 and 2.","GO:0030101|natural killer cell activation;GO:0042267|natural killer cell mediated cytotoxicity;GO:0050776|regulation of immune response;GO:0016032|viral process;","GO:0046658|anchored component of plasma membrane;GO:0005886|plasma membrane;","GO:0046703|natural killer cell lectin-like receptor binding;","K07986","ULBP; UL16 binding protein"]
["gene34599",47,59,128,70.8962043063279,8,19,16,15.7384747475304,4.50464263174248,2.17141265679055,{"v":4.67208959264316e-05,"d":"4.67E-05"},0.00151648905765304,"up","yes","LOC786095","protein_coding","chrNW_020190741.1:109455-116591:-","gi|528994728|ref|XP_002695745.2|",1420,0,"PREDICTED: uncharacterized protein LOC786095 [Bos taurus]","gi|89274849|gb|DQ405273.1|",2858,0,"Bos taurus chromosome 9 clone BAC CHORI-21B24, complete sequence","Q8TD07",215,{"v":1e-60,"d":"1.00E-60"},"Retinoic acid early transcript 1E",".",".",".",".","pfam14586","MHC_I_2","Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2. Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.","GO:0042267|natural killer cell mediated cytotoxicity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0050776|regulation of immune response;GO:0001913|T cell mediated cytotoxicity;","GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0046703|natural killer cell lectin-like receptor binding;","K07987","RAET1; retinoic acid early transcript 1"]
["gene34600",323,82,29,119.960682567672,3,2,2,2.57722518544002,46.5464497419113,5.54059922754645,{"v":3.6973563408718e-20,"d":"3.70E-20"},{"v":2.45323892468403e-17,"d":"2.45E-17"},"up","yes","LOC112445509","pseudogene","chrNW_020190741.1:118520-119800:+","gi|521024312|gb|EPQ06100.1|",310,{"v":2e-63,"d":"2.00E-63"},"Tyrosine-protein kinase RYK [Myotis brandtii]","gi|89274849|gb|DQ405273.1|",1281,0,"Bos taurus chromosome 9 clone BAC CHORI-21B24, complete sequence","P34925",137,{"v":5e-43,"d":"5.00E-43"},"Tyrosine-protein kinase RYK",".",".",".",".","pfam02019","WIF","WIF domain. The WIF domain is found in the RYK tyrosine kinase receptors and WIF, the Wnt-inhibitory- factor. The domain is extracellular and contains two conserved cysteines that may form a disulphide bridge. This domain is Wnt binding in WIF, and it has been suggested that RYK may also bind to Wnt. The WIF domain is a member of the immunoglobulin superfamily, and it comprises nine beta-strands and two alpha-helices, with two of the beta-strands (6 and 9) interrupted by four and six residues of irregular secondary structure, respectively. Considering that the activity of Wnts depends on the presence of a palmitoylated cysteine residue in their amino-terminal polypeptide segment, Wnt proteins are lipid-modified and can act as stem cell growth factors, it is likely that the WIF domain recognizes and binds to Wnts that have been activated by palmitoylation and that the recognition of palmitoylated Wnts by WIF-1 is effected by its WIF domain rather than by its EGF domains. A strong binding affinity for palmitoylated cysteine residues would further explain the remarkably high affinity of human WIF-1 not only for mammalian Wnts, but also for Wnts from Xenopus and Drosophila.","GO:0007411|axon guidance;GO:0007409|axonogenesis;GO:0060070|canonical Wnt signaling pathway;GO:0033278|cell proliferation in midbrain;GO:0071679|commissural neuron axon guidance;GO:0022038|corpus callosum development;GO:0022008|neurogenesis;GO:0030182|neuron differentiation;GO:0031175|neuron projection development;GO:0035567|non-canonical Wnt signaling pathway;GO:0043410|positive regulation of MAPK cascade;GO:0007165|signal transduction;GO:0007416|synapse assembly;GO:0016055|Wnt signaling pathway;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0005109|frizzled binding;GO:0016301|kinase activity;GO:0004888|transmembrane signaling receptor activity;GO:0042813|Wnt-activated receptor activity;GO:0017147|Wnt-protein binding;","K05128","RYK; RYK receptor-like tyrosine kinase [EC:2.7.10.1]"]
["gene34865",34,1,0,9.18890773163778,0,0,0,0,"Inf","Inf",0.000956351837239594,0.0174349356346855,"up","yes","LOC107131271","protein_coding","chrNW_020191578.1:41917-223794:+","gi|741907692|ref|XP_010797560.1|",4950,0,"PREDICTED: multidrug resistance-associated protein 4-like isoform X1 [Bos taurus]","gi|982992230|ref|XM_010799258.2|",2720,0,"PREDICTED: Bos taurus multidrug resistance-associated protein 4-like (LOC509854), transcript variant X1, mRNA","O15439",1735,0,"Multidrug resistance-associated protein 4","YDR135c",643,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0060271|cilium morphogenesis;GO:0002576|platelet degranulation;GO:0032310|prostaglandin secretion;GO:0055085|transmembrane transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0031088|platelet dense granule membrane;","GO:0016404|15-hydroxyprostaglandin dehydrogenase (NAD+) activity;GO:0005524|ATP binding;GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0043225|anion transmembrane-transporting ATPase activity;","K05673","ABCC4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4"]
["gene34885",13,92,264,114.618239838416,7,24,17,17.560617390746,6.52700513245148,2.70642117375259,0.000106715157675195,0.00305034687887527,"up","yes","LOC100848282","protein_coding","chrNW_020191650.1:10191-19703:-","gi|982935475|ref|XP_015328392.1|",1434,0,"PREDICTED: NKG2D ligand 4 [Bos taurus]","gi|34849947|gb|AC092858.21|",2908,0,"Bos taurus clone rp42-147e22, complete sequence","Q8TD07",198,{"v":6e-55,"d":"6.00E-55"},"Retinoic acid early transcript 1E",".",".",".",".","pfam14586","MHC_I_2","Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2. Members of this family are known as retinoic-acid-inducible proteins. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages.","GO:0042267|natural killer cell mediated cytotoxicity;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0050776|regulation of immune response;GO:0001913|T cell mediated cytotoxicity;","GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0046703|natural killer cell lectin-like receptor binding;","K07987","RAET1; retinoic acid early transcript 1"]
["gene3504",3245,6861,8341,5655.89494649511,1683,2448,2056,2269.59752332718,2.49202551922232,1.31731884214481,{"v":5.56464977162848e-07,"d":"5.56E-07"},{"v":3.70946314566197e-05,"d":"3.71E-05"},"up","yes","HJV","protein_coding","chrNC_037330.1:21365301-21369701:+","gi|594032403|ref|XP_006040968.1|",1592,0,"PREDICTED: hemojuvelin isoform X1 [Bubalus bubalis]","gi|982916748|ref|XM_005203975.3|",2199,0,"PREDICTED: Bos taurus hemochromatosis type 2 (juvenile) (HFE2), transcript variant X1, mRNA","Q6ZVN8",577,0,"Hemojuvelin",".",".",".",".","pfam06534","RGM_C","Repulsive guidance molecule (RGM) C-terminus. This family consists of several mammalian and one bird sequence from Gallus gallus (Chicken). This family represents the C-terminal region of several sequences but in others it represents the full protein. All of the mammalian proteins are hypothetical and have no known function but RGMA from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.","GO:0032924|activin receptor signaling pathway;GO:0030509|BMP signaling pathway;GO:0006879|cellular iron ion homeostasis;GO:0071773|cellular response to BMP stimulus;GO:0055072|iron ion homeostasis;GO:0030514|negative regulation of BMP signaling pathway;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0016540|protein autoprocessing;","GO:0031225|anchored component of membrane;GO:0070724|BMP receptor complex;GO:0009986|cell surface;GO:0005615|extracellular space;GO:1990712|HFE-transferrin receptor complex;GO:0005886|plasma membrane;GO:0098797|plasma membrane protein complex;","GO:0036122|BMP binding;GO:0015026|coreceptor activity;GO:0005102|receptor binding;GO:1990459|transferrin receptor binding;","K06847","RGM; RGM domain family"]
["gene3524",722,538,1195,731.492440570573,370,234,288,328.129476386471,2.22927988252119,1.15657775602207,0.000549426839502469,0.0113345604901265,"up","yes","GJA5","protein_coding","chrNC_037330.1:21877662-21895679:+","gi|528942975|ref|XP_005204050.1|",1717,0,"PREDICTED: gap junction alpha-5 protein isoform X1 [Bos taurus]","gi|742089966|ref|XM_010833245.1|",3328,0,"PREDICTED: Bison bison bison gap junction protein, alpha 5, 40kDa (GJA5), mRNA","Q0VCR2",662,0,"Gap junction alpha-5 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0007154|cell communication;","GO:0005922|connexon complex;GO:0016021|integral component of membrane;",".","K07614","GJA5, CX40; gap junction protein, alpha 5"]
["gene3567",57,195,67,99.3376213966922,34,27,38,36.3337491902242,2.73403168158103,1.45102996079145,0.00182443247613825,0.028755939036774,"up","yes","PHGDH","protein_coding","chrNC_037330.1:23565152-23596343:-","gi|86821596|gb|AAI05480.1|",2673,0,"Phosphoglycerate dehydrogenase [Bos taurus]","gi|86821595|gb|BC105479.1|",1840,0,"Bos taurus phosphoglycerate dehydrogenase, mRNA (cDNA clone MGC:128463 IMAGE:7984337), complete cds","Q5EAD2",1029,0,"D-3-phosphoglycerate dehydrogenase","MJ1018",322,{"v":9e-101,"d":"9.00E-101"},"COG0111","pfam00389","2-Hacid_dh","D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain. This family represents the largest portion of the catalytic domain of 2-hydroxyacid dehydrogenases as the NAD binding domain is inserted within the structural domain.","GO:0006564|L-serine biosynthetic process;",".","GO:0030060|L-malate dehydrogenase activity;GO:0051287|NAD binding;GO:0004617|phosphoglycerate dehydrogenase activity;","K00058","serA, PHGDH; D-3-phosphoglycerate dehydrogenase [EC:1.1.1.95]"]
["gene3573",10691,15363,13098,11843.7288876657,3612,5424,4293,4890.24752607631,2.42190785323468,1.27614397559776,{"v":5.1934712303116e-06,"d":"5.19E-06"},0.000243708762618454,"up","yes","TBX15","protein_coding","chrNC_037330.1:24129612-24255111:+","gi|528943057|ref|XP_005204087.1|",2859,0,"PREDICTED: T-box transcription factor TBX15 isoform X1 [Bos taurus]","gi|982916820|ref|XM_005204030.3|",4607,0,"PREDICTED: Bos taurus T-box 15 (TBX15), transcript variant X2, mRNA","Q96SF7",1091,0,"T-box transcription factor TBX15",".",".",".",".","pfam00907","T-box","T-box. The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.","GO:0048701|embryonic cranial skeleton morphogenesis;GO:0006351|transcription, DNA-templated;","GO:0070722|Tle3-Aes complex;","GO:0046982|protein heterodimerization activity;GO:0042803|protein homodimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001106|RNA polymerase II transcription corepressor activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K10182","TBX15, TBX14; T-box protein 15"]
["gene3597",417,323,470,358.879867940237,80,87,84,92.1510883469447,3.89447237550869,1.96142788469294,{"v":6.10476020376032e-10,"d":"6.10E-10"},{"v":8.66541857579531e-08,"d":"8.67E-08"},"up","yes","IGSF3","protein_coding","chrNC_037330.1:26640604-26701306:+","gi|296489495|tpg|DAA31608.1|",6200,0,"TPA: immunoglobulin superfamily, member 3 [Bos taurus]","gi|330340464|ref|NM_001192700.2|",3603,0,"Bos taurus immunoglobulin superfamily, member 3 (IGSF3), mRNA","O75054",2141,0,"Immunoglobulin superfamily member 3",".",".",".",".","pfam03157","Glutenin_hmw","High molecular weight glutenin subunit. Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.","GO:0007166|cell surface receptor signaling pathway;GO:0032808|lacrimal gland development;","GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".","K06522","IGSF2_3; immunoglobulin superfamily, member 2/3"]
["gene3599",5044,6971,11417,7105.5112392547,1797,2255,2004,2222.60789459373,3.19692522308507,1.67668499949972,{"v":1.5715288962972e-10,"d":"1.57E-10"},{"v":2.45012518799209e-08,"d":"2.45E-08"},"up","yes","ATP1A1","protein_coding","chrNC_037330.1:26886570-26918899:-","gi|116003819|ref|NP_001070266.1|",5251,0,"sodium/potassium-transporting ATPase subunit alpha-1 [Bos taurus]","gi|116003818|ref|NM_001076798.1|",3640,0,"Bos taurus ATPase, Na+/K+ transporting, alpha 1 polypeptide (ATP1A1), mRNA","Q08DA1",2027,0,"Sodium/potassium-transporting ATPase subunit alpha-1","MA4378",620,0,"COG0474","pfam00122","E1-E2_ATPase","E1-E2 ATPase.","GO:0002028|regulation of sodium ion transport;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0042383|sarcolemma;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0005391|sodium:potassium-exchanging ATPase activity;","K01539","ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]"]
["gene3624",7394,18226,11815,11528.672735466,3329,4186,3705,4117.88848773455,2.79965636995878,1.4852497615347,{"v":1.12608543076427e-07,"d":"1.13E-07"},{"v":9.36686397234264e-06,"d":"9.37E-06"},"up","yes","AMPD1","protein_coding","chrNC_037330.1:28636405-28658779:+","gi|742231815|ref|XP_010829059.1|",4006,0,"PREDICTED: AMP deaminase 1 isoform X1 [Bison bison bison]","gi|154152078|ref|NM_001100349.1|",2309,0,"Bos taurus adenosine monophosphate deaminase 1 (AMPD1), mRNA","P23109",1439,0,"AMP deaminase 1","SPBC106.04",555,0,"COG1816","pfam00962","A_deaminase","Adenosine/AMP deaminase.","GO:0032264|IMP salvage;GO:0043101|purine-containing compound salvage;GO:0010033|response to organic substance;","GO:0005829|cytosol;","GO:0003876|AMP deaminase activity;GO:0046872|metal ion binding;GO:0032036|myosin heavy chain binding;","K01490","AMPD; AMP deaminase [EC:3.5.4.6]"]
["gene3658",765,990,1037,842.302412645829,252,331,263,310.598313725299,2.71187052673693,1.43928830130114,{"v":6.67982142220005e-08,"d":"6.68E-08"},{"v":5.82819525984066e-06,"d":"5.83E-06"},"up","yes","PPM1J","protein_coding","chrNC_037330.1:30609679-30615191:+","gi|742231956|ref|XP_010829095.1|",1728,0,"PREDICTED: protein phosphatase 1J isoform X1 [Bison bison bison]","gi|982978861|ref|XM_015462634.1|",1832,0,"PREDICTED: Bos taurus protein phosphatase, Mg2+/Mn2+ dependent 1J (PPM1J), transcript variant X4, mRNA","Q5JR12",646,0,"Protein phosphatase 1J",".",".",".",".","pfam00481","PP2C","Protein phosphatase 2C. Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.",".",".","GO:0004722|protein serine/threonine phosphatase activity;","K17504","PPM1J, PP2CZ; protein phosphatase 1J [EC:3.1.3.16]"]
["gene366",4162,3707,5540,4001.01719872003,1127,813,1131,1127.8578680674,3.54744805351744,1.8267815585687,{"v":1.15855008657185e-13,"d":"1.16E-13"},{"v":3.27273193267143e-11,"d":"3.27E-11"},"up","yes","CCDC80","protein_coding","chrNC_037328.1:57376258-57478031:-","gi|149773543|ref|NP_001092452.1|",3740,0,"coiled-coil domain-containing protein 80 precursor [Bos taurus]","gi|154425572|gb|BC151288.1|",3038,0,"Bos taurus coiled-coil domain containing 80, mRNA (cDNA clone MGC:160012 IMAGE:8522830), complete cds","Q76M96",674,0,"Coiled-coil domain-containing protein 80",".",".",".",".","pfam13778","DUF4174","Domain of unknown function (DUF4174). This domain of unknown function is found in a putative tumor suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.","GO:0030198|extracellular matrix organization;GO:0010811|positive regulation of cell-substrate adhesion;","GO:0005604|basement membrane;GO:0005614|interstitial matrix;","GO:0001968|fibronectin binding;GO:0008201|heparin binding;",".","."]
["gene3742",524,701,649,565.618609437654,197,300,268,280.469318568724,2.01668621838598,1.01198662862397,0.000356369162503116,0.00805671044007639,"up","yes","CELSR2","protein_coding","chrNC_037330.1:34131458-34157401:-","gi|300793712|ref|NP_001179860.1|",13656,0,"cadherin EGF LAG seven-pass G-type receptor 2 precursor [Bos taurus]","gi|594056017|ref|XM_006052161.1|",9928,0,"PREDICTED: Bubalus bubalis cadherin, EGF LAG seven-pass G-type receptor 2 (CELSR2), transcript variant X2, mRNA","Q9HCU4",5121,0,"Cadherin EGF LAG seven-pass G-type receptor 2",".",".",".",".","pfam12003","DUF3497","Domain of unknown function (DUF3497). This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 213 to 257 amino acids in length. This domain is found associated with pfam02793, pfam00002, pfam01825. This domain has a single completely conserved residue W that may be functionally important.","GO:0048813|dendrite morphogenesis;GO:0007186|G-protein coupled receptor signaling pathway;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0021999|neural plate anterior/posterior regionalization;GO:0022407|regulation of cell-cell adhesion;GO:0006355|regulation of transcription, DNA-templated;GO:0016055|Wnt signaling pathway;GO:0060071|Wnt signaling pathway, planar cell polarity pathway;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0004930|G-protein coupled receptor activity;","K04601","CELSR2; cadherin EGF LAG seven-pass G-type receptor 2"]
["gene3744",3,81,8,29.7839747951074,1,3,2,2.1966765740597,13.5586527151165,3.76114192396723,{"v":1.92142513675384e-05,"d":"1.92E-05"},0.000735841350023139,"up","yes","KIAA1324","protein_coding","chrNC_037330.1:34197899-34275040:-","gi|741874625|ref|XP_010825197.1|",5452,0,"PREDICTED: UPF0577 protein KIAA1324 homolog [Bos taurus]","gi|982978930|ref|XM_010826895.2|",5880,0,"PREDICTED: Bos taurus KIAA1324 ortholog (KIAA1324), mRNA","Q6UXG2",1961,0,"UPF0577 protein KIAA1324",".",".",".",".","pfam03302","VSP","Giardia variant-specific surface protein.","GO:0000045|autophagosome assembly;GO:0009267|cellular response to starvation;GO:2000786|positive regulation of autophagosome assembly;GO:0044090|positive regulation of vacuole organization;","GO:0070062|extracellular exosome;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0031902|late endosome membrane;GO:0005765|lysosomal membrane;GO:0005886|plasma membrane;","GO:0003723|RNA binding;",".","."]
["gene3793",6459,2073,3628,3476.96152245055,1536,1407,1558,1652.85505630228,2.10360945395242,1.0728668856447,{"v":2.41964190002847e-05,"d":"2.42E-05"},0.000885061577560413,"up","yes","S1PR1","protein_coding","chrNC_037330.1:42032955-42039324:-","gi|61889066|ref|NP_001013603.2|",1878,0,"sphingosine 1-phosphate receptor 1 [Bos taurus]","gi|612339961|gb|KJ635883.1|",4091,0,"Bubalus bubalis clone BAC BBU_PL85.N12 genomic sequence","Q5E9P3",728,0,"Sphingosine 1-phosphate receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0031532|actin cytoskeleton reorganization;GO:0007193|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;GO:0001525|angiogenesis;GO:0001955|blood vessel maturation;GO:0007420|brain development;GO:0003245|cardiac muscle tissue growth involved in heart morphogenesis;GO:0016477|cell migration;GO:0006935|chemotaxis;GO:0061384|heart trabecula morphogenesis;GO:0030032|lamellipodium assembly;GO:0030595|leukocyte chemotaxis;GO:0008284|positive regulation of cell proliferation;GO:0030500|regulation of bone mineralization;GO:0045124|regulation of bone resorption;GO:0030155|regulation of cell adhesion;GO:0003376|sphingosine-1-phosphate signaling pathway;GO:0072678|T cell migration;","GO:0005768|endosome;GO:0009897|external side of plasma membrane;GO:0016021|integral component of membrane;GO:0031226|intrinsic component of plasma membrane;GO:0045121|membrane raft;GO:0005654|nucleoplasm;","GO:0001664|G-protein coupled receptor binding;GO:0038036|sphingosine-1-phosphate receptor activity;","K04288","S1PR1, EDG1; sphingosine 1-phosphate receptor 1"]
["gene3800",239,144,172,162.305220390197,67,61,61,69.4480499463911,2.33707383454949,1.22470331351985,0.00110758671384988,0.0195669080698767,"up","yes","EXTL2","protein_coding","chrNC_037330.1:42410212-42428919:+","gi|528943382|ref|XP_005204224.1|",1626,0,"PREDICTED: exostosin-like 2 isoform X1 [Bos taurus]","gi|982917049|ref|XM_005204167.3|",2706,0,"PREDICTED: Bos taurus exostosin-like glycosyltransferase 2 (EXTL2), transcript variant X1, mRNA","Q9UBQ6",556,0,"Exostosin-like 2",".",".",".",".","pfam09258","Glyco_transf_64","Glycosyl transferase family 64 domain. Members of this family catalyse the transfer reaction of N-acetylglucosamine and N-acetylgalactosamine from the respective UDP-sugars to the non-reducing end of [glucuronic acid]beta 1-3[galactose]beta 1-O-naphthalenemethanol, an acceptor substrate analog of the natural common linker of various glycosylaminoglycans. They are also required for the biosynthesis of heparan-sulphate.","GO:0015012|heparan sulfate proteoglycan biosynthetic process;GO:0036498|IRE1-mediated unfolded protein response;GO:0006044|N-acetylglucosamine metabolic process;GO:0019276|UDP-N-acetylgalactosamine metabolic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005576|extracellular region;GO:0016021|integral component of membrane;","GO:0035248|alpha-1,4-N-acetylgalactosaminyltransferase activity;GO:0001888|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity;GO:0047237|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0005539|glycosaminoglycan binding;GO:0030145|manganese ion binding;","K02369","EXTL2; alpha-1,4-N-acetylglucosaminyltransferase EXTL2 [EC:2.4.1.223]"]
["gene3837",0,16,20,11.3859155394675,0,0,0,0,"Inf","Inf",0.0002165082915742,0.00535750049167692,"up","yes","LOC107132310","pseudogene","chrNC_037330.1:45491147-45517746:-","gi|589931806|ref|XP_006978705.1|",236,{"v":3e-39,"d":"3.00E-39"},"PREDICTED: 40S ribosomal protein S20-like [Peromyscus maniculatus bairdii]","gi|850474981|gb|CP011886.1|",363,0,"Ovis canadensis canadensis isolate 43U chromosome 1 sequence","Q5R924",90.9,{"v":3e-35,"d":"3.00E-35"},"40S ribosomal protein S20","SPCC576.09",71.6,{"v":4e-24,"d":"4.00E-24"},"COG0051","pfam00338","Ribosomal_S10","Ribosomal protein S10p/S20e. This family includes small ribosomal subunit S10 from prokaryotes and S20 from eukaryotes.","GO:0006412|translation;","GO:0015935|small ribosomal subunit;","GO:0003723|RNA binding;GO:0003735|structural constituent of ribosome;",".","."]
["gene3980",0,40,0,13.1087071682637,1,0,0,0.373768090184884,35.07176645759,5.13223819144401,0.00048586235844205,0.0103603430109941,"up","yes","WDR63","protein_coding","chrNC_037330.1:58950407-59044192:-","gi|982919412|ref|XP_015320262.1|",4336,0,"PREDICTED: WD repeat-containing protein 63 isoform X2 [Bos taurus]","gi|982919411|ref|XM_015464776.1|",6399,0,"PREDICTED: Bos taurus WD repeat domain 63 (WDR63), transcript variant X2, mRNA","Q8IWG1",1450,0,"WD repeat-containing protein 63",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0007018|microtubule-based movement;","GO:0030286|dynein complex;","GO:0045504|dynein heavy chain binding;GO:0045503|dynein light chain binding;",".","."]
["gene401",38,6,32,21.6978813504748,0,3,2,1.82290848387482,11.9028911996466,3.57324014008202,0.000172169889971153,0.00452378295136175,"up","yes","LSAMP","protein_coding","chrNC_037328.1:60476761-61192322:-","gi|528936214|ref|XP_005201312.1|",1648,0,"PREDICTED: limbic system-associated membrane protein isoform X1 [Bos taurus]","gi|982909955|ref|XM_005201255.3|",9571,0,"PREDICTED: Bos taurus limbic system-associated membrane protein (LSAMP), transcript variant X1, mRNA","Q62813",571,0,"Limbic system-associated membrane protein",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007155|cell adhesion;","GO:0031225|anchored component of membrane;GO:0005886|plasma membrane;",".","K06772","LSAMP, LAMP; limbic system-associated membrane protein"]
["gene4102",750,1425,2402,1400.17128442321,294,550,390,452.510407955314,3.09423001064205,1.62958044400052,0.000150209809092845,0.00409316884556721,"up","yes","PDE4B","protein_coding","chrNC_037330.1:78957188-79406811:-","gi|156523204|ref|NP_001096016.1|",2580,0,"cAMP-specific 3',5'-cyclic phosphodiesterase 4B [Bos taurus]","gi|982919524|ref|XM_005204436.3|",3384,0,"PREDICTED: Bos taurus phosphodiesterase 4B (PDE4B), transcript variant X3, mRNA","Q07343",977,0,"cAMP-specific 3',5'-cyclic phosphodiesterase 4B",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0006198|cAMP catabolic process;GO:0035690|cellular response to drug;GO:0071872|cellular response to epinephrine stimulus;GO:0071222|cellular response to lipopolysaccharide;GO:0007186|G-protein coupled receptor signaling pathway;GO:0050900|leukocyte migration;GO:1901898|negative regulation of relaxation of cardiac muscle;GO:0030593|neutrophil chemotaxis;GO:0001780|neutrophil homeostasis;GO:0032729|positive regulation of interferon-gamma production;GO:0032743|positive regulation of interleukin-2 production;GO:0086004|regulation of cardiac muscle cell contraction;GO:1901841|regulation of high voltage-gated calcium channel activity;GO:0050852|T cell receptor signaling pathway;","GO:0071944|cell periphery;GO:0005813|centrosome;GO:0005829|cytosol;GO:0043197|dendritic spine;GO:0060076|excitatory synapse;GO:0000930|gamma-tubulin complex;GO:0016020|membrane;GO:0014069|postsynaptic density;GO:0008021|synaptic vesicle;GO:0030018|Z disc;","GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0030552|cAMP binding;GO:0043015|gamma-tubulin binding;GO:0044325|ion channel binding;GO:0046872|metal ion binding;","K13293","PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]"]
["gene4118",467,633,378,445.248320044146,92,134,78,111.718883840948,3.98543473346938,1.99473710278843,{"v":1.34901644857146e-07,"d":"1.35E-07"},{"v":1.08419121955471e-05,"d":"1.08E-05"},"up","yes","RAVER2","protein_coding","chrNC_037330.1:80583997-80721371:-","gi|741874957|ref|XP_010825293.1|",3510,0,"PREDICTED: ribonucleoprotein PTB-binding 2 isoform X1 [Bos taurus]","gi|982979324|ref|XM_010826991.2|",4311,0,"PREDICTED: Bos taurus ribonucleoprotein, PTB-binding 2 (RAVER2), transcript variant X1, mRNA","Q9HCJ3",1238,0,"Ribonucleoprotein PTB-binding 2",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0000398|mRNA splicing, via spliceosome;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003676|nucleic acid binding;GO:0003723|RNA binding;",".","."]
["gene412",7787,2501,3146,3815.29972027035,1388,1298,1322,1472.3461322601,2.59130624020707,1.37367952309054,{"v":7.62280862740162e-08,"d":"7.62E-08"},{"v":6.55079376350589e-06,"d":"6.55E-06"},"up","yes","ARHGAP31","protein_coding","chrNC_037328.1:64083098-64205638:+","gi|329663235|ref|NP_001192739.1|",6855,0,"rho GTPase-activating protein 31 [Bos taurus]","gi|742148375|ref|XM_010845367.1|",7631,0,"PREDICTED: Bison bison bison Rho GTPase activating protein 31 (ARHGAP31), mRNA","Q2M1Z3",2144,0,"Rho GTPase-activating protein 31",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0051056|regulation of small GTPase mediated signal transduction;GO:0007264|small GTPase mediated signal transduction;","GO:0005829|cytosol;GO:0005925|focal adhesion;GO:0030027|lamellipodium;","GO:0005096|GTPase activator activity;GO:0017124|SH3 domain binding;",".","."]
["gene4126",26538,82884,58942,52181.3349106473,11062,23291,16282,18559.490652754,2.8115714965973,1.49137673422528,0.00259581973233287,0.037114672692448,"up","yes","PGM1","protein_coding","chrNC_037330.1:81912494-81978206:-","gi|528944292|ref|XP_005204573.1|",2950,0,"PREDICTED: phosphoglucomutase-1 isoform X1 [Bos taurus]","gi|742092655|ref|XM_010833891.1|",2757,0,"PREDICTED: Bison bison bison phosphoglucomutase 1 (PGM1), transcript variant X1, mRNA","Q08DP0",1026,0,"Phosphoglucomutase-1","SMc03925",556,0,"COG0033","pfam02878","PGM_PMM_I","Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I.","GO:0019388|galactose catabolic process;GO:0006006|glucose metabolic process;GO:0005978|glycogen biosynthetic process;","GO:0005829|cytosol;","GO:0000287|magnesium ion binding;GO:0004614|phosphoglucomutase activity;","K01835","pgm; phosphoglucomutase [EC:5.4.2.2]"]
["gene4207",0,56,0,18.3521900355691,0,1,0,0.366987568989444,50.007661257041,5.6440772299915,{"v":2.65387526144287e-05,"d":"2.65E-05"},0.000951227576435008,"up","yes","MROH7","protein_coding","chrNC_037330.1:91567418-91621085:-","gi|356991163|ref|NP_001071417.2|",6334,0,"maestro heat-like repeat-containing protein family member 7 [Bos taurus]","gi|356991162|ref|NM_001077949.2|",4315,0,"Bos taurus maestro heat-like repeat family member 7 (MROH7), mRNA","Q68CQ1",1806,0,"Maestro heat-like repeat-containing protein family member 7",".",".",".",".","pfam06413","Neugrin","Neugrin. This family consists of several mouse and human neugrin proteins. Neugrin and m-neugrin are mainly expressed in neurons in the nervous system, and are thought to play an important role in the process of neuronal differentiation.",".","GO:0005615|extracellular space;GO:0016021|integral component of membrane;",".",".","."]
["gene421",422,918,1846,977.774371097088,69,252,140,168.807069991551,5.79225959639028,2.53412626230237,0.00138979490482198,0.0234906625767038,"up","yes","POPDC2","protein_coding","chrNC_037328.1:64397362-64415670:-","gi|149642743|ref|NP_001092582.1|",1732,0,"popeye domain-containing protein 2 [Bos taurus]","gi|965813526|ref|XM_012122335.2|",1917,0,"PREDICTED: Ovis aries musimon popeye domain containing 2 (POPDC2), transcript variant X3, mRNA","Q9HBU9",520,{"v":2e-178,"d":"2.00E-178"},"Popeye domain-containing protein 2",".",".",".",".","pfam04831","Popeye","Popeye protein conserved region. The function of Popeye proteins is not well understood. They are predominantly expressed in cardiac and skeletal muscle. This family represents a conserved region which includes three potential transmembrane domains.","GO:0002027|regulation of heart rate;","GO:0016021|integral component of membrane;GO:0042383|sarcolemma;",".",".","."]
["gene4336",920,319,403,468.085335900282,228,135,166,194.683945858967,2.40433454250702,1.26563764864331,0.000759426582899094,0.0146796746861071,"up","yes","PIK3R3","protein_coding","chrNC_037330.1:99908977-100067354:+","gi|555964411|ref|XP_005894274.1|",2300,0,"PREDICTED: phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [Bos mutus]","gi|742157232|ref|XM_010847867.1|",4726,0,"PREDICTED: Bison bison bison phosphoinositide-3-kinase, regulatory subunit 3 (gamma) (PIK3R3), transcript variant X2, mRNA","O46404",885,0,"Phosphatidylinositol 3-kinase regulatory subunit gamma",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0008286|insulin receptor signaling pathway;GO:0046854|phosphatidylinositol phosphorylation;GO:2001275|positive regulation of glucose import in response to insulin stimulus;GO:0043551|regulation of phosphatidylinositol 3-kinase activity;","GO:0005942|phosphatidylinositol 3-kinase complex;","GO:0046935|1-phosphatidylinositol-3-kinase regulator activity;","K02649","PIK3R; phosphoinositide-3-kinase, regulatory subunit"]
["gene434",891,653,1044,766.849934029827,299,296,341,343.476734348711,2.2326109961535,1.1587319019398,{"v":1.54318604111981e-05,"d":"1.54E-05"},0.000613212269348039,"up","yes","NDUFB4","protein_coding","chrNC_037328.1:65318371-65324509:+","gi|28461263|ref|NP_787016.1|",673,{"v":5e-88,"d":"5.00E-88"},"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [Bos taurus]","gi|31343600|ref|NM_175822.2|",474,0,"Bos taurus NADH:ubiquinone oxidoreductase subunit B4 (NDUFB4), mRNA","P48305",263,{"v":2e-89,"d":"2.00E-89"},"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4",".",".",".",".","pfam07225","NDUF_B4","NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4). This family consists of several NADH-ubiquinone oxidoreductase B15 subunit proteins (EC:1.6.5.3).","GO:0032981|mitochondrial respiratory chain complex I assembly;GO:0006979|response to oxidative stress;","GO:0016021|integral component of membrane;GO:0005747|mitochondrial respiratory chain complex I;","GO:0008137|NADH dehydrogenase (ubiquinone) activity;","K03960","NDUFB4; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4"]
["gene4418",624,231,261,318.490430054233,114,142,136,143.814109907219,2.21459792964477,1.1470447946895,0.000285995620797813,0.00673801903962214,"up","yes","TIE1","protein_coding","chrNC_037330.1:102694836-102714367:-","gi|296488838|tpg|DAA30951.1|",5799,0,"TPA: tyrosine-protein kinase receptor Tie-1 precursor [Bos taurus]","gi|31343161|ref|NM_173965.2|",3594,0,"Bos taurus tyrosine kinase with immunoglobulin like and EGF like domains 1 (TIE1), mRNA","Q06805",2219,0,"Tyrosine-protein kinase receptor Tie-1",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001525|angiogenesis;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0004714|transmembrane receptor protein tyrosine kinase activity;","K05120","TIE1; tyrosine kinase receptor 1 [EC:2.7.10.1]"]
["gene4462",773,339,501,466.425993763085,30,88,50,61.5565931992797,7.57718985930726,2.92166289750828,{"v":2.40950617759776e-06,"d":"2.41E-06"},0.00012707138771357,"up","yes","FOXO6","protein_coding","chrNC_037330.1:104815304-104837023:-","gi|803274185|ref|XP_011996764.1|",900,{"v":1e-101,"d":"1.00E-101"},"PREDICTED: forkhead box protein O6 isoform X2 [Ovis aries musimon]","gi|850474981|gb|CP011886.1|",2223,0,"Ovis canadensis canadensis isolate 43U chromosome 1 sequence","Q70KY4",235,{"v":8e-64,"d":"8.00E-64"},"Forkhead box protein O6",".",".",".",".","pfam00250","Fork_head","Fork head domain.","GO:0009653|anatomical structure morphogenesis;GO:0007613|memory;GO:0060999|positive regulation of dendritic spine development;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;","K17847","FOXO6; forkhead box protein O6"]
["gene4501",843,56,20,244.200011360657,66,73,74,78.1707802339717,3.12392956331951,1.64336192473621,{"v":5.98766629384613e-06,"d":"5.99E-06"},0.000275095180402132,"up","yes","HPCAL4","protein_coding","chrNC_037330.1:106385888-106398496:+","gi|528944864|ref|XP_005204827.1|",1198,{"v":5e-148,"d":"5.00E-148"},"PREDICTED: hippocalcin-like protein 4 isoform X1 [Bos taurus]","gi|982920109|ref|XM_005204770.3|",4684,0,"PREDICTED: Bos taurus hippocalcin like 4 (HPCAL4), transcript variant X1, mRNA","Q5R6S5",395,{"v":3e-125,"d":"3.00E-125"},"Hippocalcin-like protein 4","SPAC18B11.04",226,{"v":1e-65,"d":"1.00E-65"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0007165|signal transduction;",".","GO:0005246|calcium channel regulator activity;GO:0005509|calcium ion binding;",".","."]
["gene4502",857,901,790,761.253833484173,219,279,287,287.843962484625,2.64467535435916,1.403090635987,{"v":2.04552364719183e-07,"d":"2.05E-07"},{"v":1.53581145205342e-05,"d":"1.54E-05"},"up","yes","NT5C1A","protein_coding","chrNC_037330.1:106403642-106419979:+","gi|329663167|ref|NP_001192475.1|",1702,0,"cytosolic 5'-nucleotidase 1A [Bos taurus]","gi|998248157|ref|NM_001205546.2|",2185,0,"Bos taurus 5'-nucleotidase, cytosolic IA (NT5C1A), mRNA","Q9BXI3",635,0,"Cytosolic 5'-nucleotidase 1A",".",".",".",".","pfam06189","5-nucleotidase","5'-nucleotidase. This family consists of both eukaryotic and prokaryotic 5'-nucleotidase sequences (EC:3.1.3.5).","GO:0046085|adenosine metabolic process;GO:0009116|nucleoside metabolic process;GO:0009128|purine nucleoside monophosphate catabolic process;GO:0006195|purine nucleotide catabolic process;GO:0046135|pyrimidine nucleoside catabolic process;","GO:0005829|cytosol;","GO:0008253|5'-nucleotidase activity;GO:0000287|magnesium ion binding;GO:0000166|nucleotide binding;","K01081","E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]"]
["gene4503",2079,718,1069,1105.45002937988,491,195,378,391.530460069045,2.82340747942047,1.49743735624633,0.00327234275423394,0.0439770188982801,"up","yes","HEYL","protein_coding","chrNC_037330.1:106442713-106458224:+","gi|528944912|ref|XP_005204851.1|",1283,{"v":7e-164,"d":"7.00E-164"},"PREDICTED: hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [Bos taurus]","gi|982920130|ref|XM_005204794.3|",3412,0,"PREDICTED: Bos taurus hes-related family bHLH transcription factor with YRPW motif-like (HEYL), transcript variant X1, mRNA","Q2NL18",489,{"v":1e-161,"d":"1.00E-161"},"Hairy/enhancer-of-split related with YRPW motif-like protein",".",".",".",".","pfam07527","Hairy_orange","Hairy Orange. The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split. The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute.","GO:0007275|multicellular organismal development;GO:0007219|Notch signaling pathway;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046983|protein dimerization activity;",".","."]
["gene4529",4702,15759,18011,11921.5211091361,3081,5700,4876,5003.51243319747,2.38263045576519,1.25255520793708,0.00211060024173529,0.0320132219460575,"up","yes","FHL3","protein_coding","chrNC_037330.1:107958890-107967123:+","gi|955508272|ref|XP_004426038.2|",1496,0,"PREDICTED: four and a half LIM domains protein 3 isoform X1 [Ceratotherium simum simum]","gi|402745762|ref|NM_001034223.2|",1607,0,"Bos taurus four and a half LIM domains 3 (FHL3), mRNA","Q3ZBI6",572,0,"Four and a half LIM domains protein 3",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0030036|actin cytoskeleton organization;","GO:0005634|nucleus;GO:0001725|stress fiber;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0046872|metal ion binding;",".","."]
["gene4532",692,754,709,645.199648240573,265,325,271,316.143156591392,2.04084647979421,1.02916766146433,0.000188359448077756,0.00481980575166499,"up","yes","MTF1","protein_coding","chrNC_037330.1:108062883-108103486:+","gi|115749616|ref|NP_001030252.2|",3386,0,"metal regulatory transcription factor 1 [Bos taurus]","gi|115749615|ref|NM_001035080.2|",3488,0,"Bos taurus metal-regulatory transcription factor 1 (MTF1), mRNA","Q14872",1166,0,"Metal regulatory transcription factor 1","SPAC144.09c",104,{"v":9e-23,"d":"9.00E-23"},"COG5048","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0046686|response to cadmium ion;GO:0010038|response to metal ion;GO:0006979|response to oxidative stress;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0001047|core promoter binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0035035|histone acetyltransferase binding;GO:0046872|metal ion binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003713|transcription coactivator activity;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;",".","."]
["gene4547",104,54,26,52.7867337819326,11,6,16,12.0889406212223,4.36653098363844,2.12648757716407,0.000277813783963791,0.00659426378558312,"up","yes","GRIK3","protein_coding","chrNC_037330.1:108832697-109076297:+","gi|880956999|ref|XP_005084428.2|",2073,0,"PREDICTED: glutamate receptor ionotropic, kainate 3 isoform X1 [Mesocricetus auratus]","gi|329664661|ref|NM_001206003.1|",1214,0,"Bos taurus glutamate receptor, ionotropic, kainate 3 (GRIK3), mRNA","Q38PU2",788,0,"Glutamate receptor ionotropic, kainate 3",".",".",".",".","pfam01094","ANF_receptor","Receptor family ligand binding region. This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.","GO:0007216|G-protein coupled glutamate receptor signaling pathway;","GO:0030054|cell junction;GO:0043197|dendritic spine;GO:0016021|integral component of membrane;GO:0045211|postsynaptic membrane;","GO:0001640|adenylate cyclase inhibiting G-protein coupled glutamate receptor activity;GO:0005234|extracellular-glutamate-gated ion channel activity;GO:0004970|ionotropic glutamate receptor activity;","K05203","GRIK3; glutamate receptor, ionotropic kainate 3"]
["gene4558",6814,13082,11857,9704.63062487384,4096,4225,4480,4698.63511664821,2.06541482450688,1.04643156622392,0.000151933884291852,0.0041199442107335,"up","yes","MAP7D1","protein_coding","chrNC_037330.1:109649571-109671700:-","gi|741875358|ref|XP_010825422.1|",1639,0,"PREDICTED: MAP7 domain-containing protein 1 isoform X1 [Bos taurus]","gi|982979713|ref|XM_010827121.2|",3652,0,"PREDICTED: Bos taurus MAP7 domain containing 1 (MAP7D1), transcript variant X2, mRNA","Q3KQU3",497,{"v":1e-156,"d":"1.00E-156"},"MAP7 domain-containing protein 1",".",".",".",".","pfam05672","MAP7","MAP7 (E-MAP-115) family. The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilizing protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.","GO:0000226|microtubule cytoskeleton organization;","GO:0005829|cytosol;GO:0015630|microtubule cytoskeleton;GO:0005819|spindle;","GO:0005198|structural molecule activity;","K16806","MAP7D1; MAP7 domain-containing protein 1"]
["gene4590",695,238,271,342.359919960131,134,126,168,156.968803037589,2.18106982620073,1.12503595810381,0.000356827233776664,0.00806067918201268,"up","yes","GJA4","protein_coding","chrNC_037330.1:110888194-110890904:-","gi|139948758|ref|NP_001077207.1|",1545,0,"gap junction alpha-4 protein [Bos taurus]","gi|139948757|ref|NM_001083738.1|",1586,0,"Bos taurus gap junction protein alpha 4 (GJA4), mRNA","A4IFL1",599,0,"Gap junction alpha-4 protein",".",".",".",".","pfam00029","Connexin","Connexin.","GO:0007154|cell communication;","GO:0005922|connexon complex;GO:0016021|integral component of membrane;",".","K07613","GJA4, CX37; gap junction protein, alpha 4"]
["gene4598",411,188,358,278.676618862223,39,95,66,73.2649852091216,3.80368081788034,1.92739618894792,0.00017668423700044,0.00459943245060179,"up","yes","CSMD2","protein_coding","chrNC_037330.1:111603940-112293818:+","gi|741875411|ref|XP_010825442.1|",18819,0,"PREDICTED: CUB and sushi domain-containing protein 2 [Bos taurus]","gi|982979744|ref|XM_010827140.2|",13323,0,"PREDICTED: Bos taurus CUB and Sushi multiple domains 2 (CSMD2), mRNA","Q7Z408",5629,0,"CUB and sushi domain-containing protein 2",".",".",".",".","pfam00431","CUB","CUB domain.",".","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".","K17495","CSMD; CUB and sushi domain-containing protein"]
["gene4599",2,23,0,8.05875309542403,0,0,0,0,"Inf","Inf",0.00209006001882,0.0317526636831489,"up","yes","HMGB4","protein_coding","chrNC_037330.1:111927002-111927609:-","gi|742125006|ref|XP_010839519.1|",1039,{"v":7e-142,"d":"7.00E-142"},"PREDICTED: high mobility group protein B4 [Bison bison bison]","gi|746816095|ref|NM_001040562.3|",608,0,"Bos taurus high mobility group box 4 (HMGB4), mRNA","Q32L34",404,{"v":2e-143,"d":"2.00E-143"},"High mobility group protein B4","YBR089c-a",62.4,{"v":5e-12,"d":"5.00E-12"},"COG5648","pfam00505","HMG_box","HMG (high mobility group) box.",".","GO:0005694|chromosome;GO:0005634|nucleus;","GO:0003677|DNA binding;","K11297","HMGB4; high mobility group protein B4"]
["gene4612",553,1818,1690,1258.9509515657,213,412,316,344.878914384256,3.65041438910065,1.8680602456821,{"v":1.41699089379502e-05,"d":"1.42E-05"},0.000574263738506614,"up","yes","LOC112446116","guide_RNA","chrNC_037330.1:112988386-112988659:+",".",".",".",".","gi|850474981|gb|CP011886.1|",229,{"v":4e-115,"d":"4.00E-115"},"Ovis canadensis canadensis isolate 43U chromosome 1 sequence",".",".",".",".",".",".",".",".","pfam10213","MRP-S28","Mitochondrial ribosomal subunit protein. This is a conserved region of approx. 125 residues of one of the proteins that makes up the small subunit of the mitochondrial ribosome. In Saccharomyces cerevisiae the protein is MRP-S24 whereas in humans it is MRP-S28. The human mitochondrial ribosome has 29 distinct proteins in the small subunit and these have homologues in, for example, Drosophila melanogaster, Caenorhabditis elegans, and in the genomes of several fungi.",".",".",".",".","."]
["gene4654",18528,23611,33239,22774.9854353479,10548,6138,9284,9546.34781012726,2.385727598484,1.25442932603763,0.000563712894369245,0.0115623958226089,"up","yes","COL6A3","protein_coding","chrNC_037330.1:116781707-116872758:-","gi|528902842|ref|XP_005198020.1|",10348,0,"PREDICTED: collagen alpha-3(VI) chain isoform X1 [Bos taurus]","gi|982979825|ref|XM_005197963.3|",10695,0,"PREDICTED: Bos taurus collagen type VI alpha 3 (COL6A3), transcript variant X1, mRNA","P12111",3584,0,"Collagen alpha-3(VI) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.","GO:0007155|cell adhesion;GO:0030198|extracellular matrix organization;GO:0007517|muscle organ development;","GO:0005589|collagen type VI trimer;GO:0005788|endoplasmic reticulum lumen;GO:0070062|extracellular exosome;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:1903561|extracellular vesicle;GO:0042383|sarcolemma;","GO:0004867|serine-type endopeptidase inhibitor activity;","K06238","COL6A; collagen, type VI, alpha"]
["gene467",760,959,1201,881.207996317972,356,324,359,381.554679413112,2.30951956263097,1.20759276649054,{"v":5.006381510579e-06,"d":"5.01E-06"},0.000235586964171183,"up","yes","DIRC2","protein_coding","chrNC_037328.1:67121600-67210224:+","gi|155372289|ref|NP_001094757.1|",1971,0,"disrupted in renal carcinoma protein 2 [Bos taurus]","gi|155372288|ref|NM_001101287.1|",2452,0,"Bos taurus disrupted in renal carcinoma 2 (DIRC2), mRNA","Q8BFQ6",741,0,"Disrupted in renal carcinoma protein 2 homolog",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.",".","GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005765|lysosomal membrane;",".","K15381","DIRC2, SLC49A3; MFS transporter, FLVCR family, disrupted in renal carcinoma protein 2"]
["gene4670",148,40,420,180.672032335426,31,7,34,26.4288019860677,6.83617942389782,2.77319026280846,0.000736821696165655,0.014337448281348,"up","yes","ERFE","protein_coding","chrNC_037330.1:117490169-117500140:+","gi|803260275|ref|XP_011989883.1|",944,{"v":8e-116,"d":"8.00E-116"},"PREDICTED: erythroferrone-like [Ovis aries musimon]","gi|982979850|ref|XM_015462856.1|",2599,0,"PREDICTED: Bos taurus family with sequence similarity 132 member B (FAM132B), transcript variant X2, mRNA","Q4G0M1",299,{"v":4e-91,"d":"4.00E-91"},"Erythroferrone",".",".",".",".","pfam04817","Umbravirus_LDM","Umbravirus long distance movement (LDM) family. The long distance movement protein of Umbraviruses mediates the movement of viral RNA through the phloem of infected plants.","GO:0006879|cellular iron ion homeostasis;GO:2000193|positive regulation of fatty acid transport;GO:0019217|regulation of fatty acid metabolic process;","GO:0005623|cell;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005179|hormone activity;GO:0042803|protein homodimerization activity;",".","."]
["gene4674",1626,3553,2286,2290.23435174482,410,781,639,670.52388407818,3.41558952056328,1.77213460486739,{"v":1.53356174780708e-05,"d":"1.53E-05"},0.00061090897901552,"up","yes","PER2","protein_coding","chrNC_037330.1:117557048-117599734:-","gi|300796796|ref|NP_001179246.1|",5915,0,"period circadian protein homolog 2 [Bos taurus]","gi|982979854|ref|XM_015462857.1|",3172,0,"PREDICTED: Bos taurus period circadian protein homolog 2-like (LOC107131159), mRNA","O54943",1461,0,"Period circadian protein homolog 2",".",".",".",".","pfam12114","Period_C","Period protein 2/3C-terminal region. This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.","GO:0032922|circadian regulation of gene expression;GO:0097167|circadian regulation of translation;GO:0007623|circadian rhythm;GO:0006631|fatty acid metabolic process;GO:0006094|gluconeogenesis;GO:0005978|glycogen biosynthetic process;GO:0070932|histone H3 deacetylation;GO:0019249|lactate biosynthetic process;GO:0042754|negative regulation of circadian rhythm;GO:0060567|negative regulation of DNA-templated transcription, termination;GO:0070345|negative regulation of fat cell proliferation;GO:0031397|negative regulation of protein ubiquitination;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:2000678|negative regulation of transcription regulatory region DNA binding;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051726|regulation of cell cycle;GO:0042752|regulation of circadian rhythm;GO:0051946|regulation of glutamate uptake involved in transmission of nerve impulse;GO:0050796|regulation of insulin secretion;GO:0050767|regulation of neurogenesis;GO:0019229|regulation of vasoconstriction;GO:0002931|response to ischemia;GO:0006351|transcription, DNA-templated;GO:0050872|white fat cell differentiation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0042826|histone deacetylase binding;GO:1990226|histone methyltransferase binding;GO:0042802|identical protein binding;GO:0019900|kinase binding;GO:0035257|nuclear hormone receptor binding;GO:0036002|pre-mRNA binding;GO:0070063|RNA polymerase binding;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0003713|transcription coactivator activity;GO:0001222|transcription corepressor binding;GO:0000989|transcription factor activity, transcription factor binding;GO:0008134|transcription factor binding;GO:0000976|transcription regulatory region sequence-specific DNA binding;","K02633","PER; period circadian protein"]
["gene4765",223,4,3,60.3512174321258,0,0,0,0,"Inf","Inf",{"v":2.36203537547048e-15,"d":"2.36E-15"},{"v":8.86726727599319e-13,"d":"8.87E-13"},"up","yes","FAM240A","protein_coding","chrNC_037330.1:120881582-120892494:-","gi|440901293|gb|ELR52268.1|",489,{"v":3e-55,"d":"3.00E-55"},"hypothetical protein M91_12507, partial [Bos mutus]","gi|982979930|ref|XR_001496193.1|",388,0,"PREDICTED: Bos taurus uncharacterized LOC101905375 (LOC101905375), transcript variant X3, misc_RNA",".",".",".",".",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["gene4777",1282,2468,2910,2036.65017570547,780,925,954,975.370747243838,2.08807797594971,1.06217558806462,{"v":3.91110882819969e-05,"d":"3.91E-05"},0.00131589441011044,"up","yes","COBL","protein_coding","chrNC_037331.1:4582570-4882166:+","gi|556775524|ref|XP_005982879.1|",4920,0,"PREDICTED: protein cordon-bleu [Pantholops hodgsonii]","gi|982980079|ref|XM_015462915.1|",4290,0,"PREDICTED: Bos taurus cordon-bleu WH2 repeat protein (COBL), transcript variant X4, mRNA","O75128",1209,0,"Protein cordon-bleu",".",".",".",".","pfam09469","Cobl","Cordon-bleu ubiquitin-like domain. The Cordon-bleu protein domain is highly conserved among vertebrates. The sequence contains three repeated lysine, arginine, and proline-rich regions, the KKRAP motif. The exact function of the protein is unknown but it is thought to be involved in mid-brain neural tube closure. It is expressed specifically in the node. This domain has a ubiquitin-like fold.","GO:0051639|actin filament network formation;GO:0030041|actin filament polymerization;GO:0048669|collateral sprouting in absence of injury;GO:0048565|digestive tract development;GO:0000578|embryonic axis specification;GO:0033504|floor plate development;GO:0001889|liver development;GO:0001843|neural tube closure;GO:0030903|notochord development;GO:1900006|positive regulation of dendrite development;GO:1900029|positive regulation of ruffle assembly;GO:0001757|somite specification;","GO:0005884|actin filament;GO:0030424|axon;GO:0044295|axonal growth cone;GO:0005938|cell cortex;GO:0030425|dendrite;GO:0044294|dendritic growth cone;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0001726|ruffle;","GO:0003785|actin monomer binding;","K18623","COBL; protein cordon-bleu"]
["gene478",0,30,0,9.83153037619775,0,0,0,0,"Inf","Inf",0.000693990117304085,0.0137447642062416,"up","yes","ROPN1","protein_coding","chrNC_037328.1:68349821-68384919:-","gi|555962753|ref|XP_005893464.1|",1130,{"v":4e-153,"d":"4.00E-153"},"PREDICTED: ropporin-1A [Bos mutus]","gi|115495918|ref|NM_001075900.1|",1018,0,"Bos taurus rhophilin associated tail protein 1 (ROPN1), mRNA","Q3T064",437,{"v":2e-153,"d":"2.00E-153"},"Ropporin-1",".",".",".",".","pfam02197","RIIa","Regulatory subunit of type II PKA R-subunit.","GO:0044782|cilium organization;GO:0030317|sperm motility;GO:0061512|protein localization to cilium;GO:0001932|regulation of protein phosphorylation;GO:0048240|sperm capacitation;","GO:0031514|motile cilium;",".",".","."]
["gene4848",24648,15054,15733,16189.2481458712,5600,2989,5005,4996.69645545328,3.23999031964461,1.69598950267114,{"v":1.58730878120994e-05,"d":"1.59E-05"},0.000628120760564503,"up","yes","COL1A2","protein_coding","chrNC_037331.1:11776444-11813113:+","gi|555996036|ref|XP_005909757.1|",1817,0,"PREDICTED: collagen alpha-2(I) chain [Bos mutus]","gi|31341767|ref|NM_174520.2|",4612,0,"Bos taurus collagen type I alpha 2 (COL1A2), mRNA","P02465",704,0,"Collagen alpha-2(I) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0001568|blood vessel development;GO:0071230|cellular response to amino acid stimulus;GO:0030199|collagen fibril organization;GO:0070208|protein heterotrimerization;GO:0008217|regulation of blood pressure;GO:0007266|Rho protein signal transduction;GO:0001501|skeletal system development;GO:0043589|skin morphogenesis;GO:0007179|transforming growth factor beta receptor signaling pathway;","GO:0005584|collagen type I trimer;GO:0005783|endoplasmic reticulum;GO:0005615|extracellular space;","GO:0005201|extracellular matrix structural constituent;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0048407|platelet-derived growth factor binding;GO:0002020|protease binding;GO:0030674|protein binding, bridging;GO:0046332|SMAD binding;","K06236","COL1AS; collagen, type I/II/III/V/XI/XXIV/XXVII, alpha"]
["gene4852",364,797,691,568.278897359233,272,225,254,275.924237220037,2.05954686360537,1.04232695413618,0.00030926753912646,0.00719128945298861,"up","yes","PEG10","protein_coding","chrNC_037331.1:12063954-12076659:+","gi|157954422|ref|NP_001103285.1|",1734,0,"retrotransposon-derived protein PEG10 isoform 4 [Bos taurus]","gi|391224443|ref|NM_001109815.5|",6509,0,"Bos taurus paternally expressed 10 (PEG10), transcript variant 2, mRNA","Q86TG7",588,0,"Retrotransposon-derived protein PEG10",".",".",".",".","pfam03732","Retrotrans_gag","Retrotransposon gag protein. Gag or Capsid-like proteins from LTR retrotransposons. There is a central motif QGXXEXXXXXFXXLXXH that is common to Retroviridae gag-proteins, but is poorly conserved.","GO:0006915|apoptotic process;GO:0030154|cell differentiation;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003723|RNA binding;GO:0008270|zinc ion binding;",".","."]
["gene4931",90,95,294,144.883031120667,27,23,29,29.0006662868931,4.99585180862369,2.32073068308386,{"v":6.49784912562881e-08,"d":"6.50E-08"},{"v":5.70431179702509e-06,"d":"5.70E-06"},"up","yes","LRRC72","protein_coding","chrNC_037331.1:25014042-25084049:+","gi|555970825|ref|XP_005897431.1|",915,{"v":1e-118,"d":"1.00E-118"},"PREDICTED: leucine-rich repeat-containing protein 72 [Bos mutus]","gi|149944730|ref|NM_001099189.1|",581,0,"Bos taurus leucine rich repeat containing 72 (LRRC72), mRNA",".",".",".",".",".",".",".",".","pfam14580","LRR_9","Leucine-rich repeat.",".",".",".",".","."]
["gene4960",485,401,734,483.244338295752,181,266,196,236.021403811492,2.04745980869478,1.03383513227369,0.000368051370866197,0.00828144610582293,"up","yes","ITGB8","protein_coding","chrNC_037331.1:29024090-29120852:+","gi|300797755|ref|NP_001179804.1|",3334,0,"integrin beta-8 precursor [Bos taurus]","gi|982921107|ref|XM_015468532.1|",7925,0,"PREDICTED: Bos taurus integrin subunit beta 8 (ITGB8), transcript variant X1, mRNA","P26012",1223,0,"Integrin beta-8",".",".",".",".","pfam00362","Integrin_beta","Integrin, beta chain. Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer. The sequences repeats have been trimmed due to an overlap with EGF.","GO:0051216|cartilage development;GO:0007155|cell adhesion;GO:0030198|extracellular matrix organization;GO:0001573|ganglioside metabolic process;GO:0007229|integrin-mediated signaling pathway;GO:0010629|negative regulation of gene expression;GO:0060674|placenta blood vessel development;GO:0045766|positive regulation of angiogenesis;GO:0010628|positive regulation of gene expression;","GO:0009986|cell surface;GO:0070062|extracellular exosome;GO:0034686|integrin alphav-beta8 complex;GO:0008305|integrin complex;GO:0005886|plasma membrane;","GO:1990430|extracellular matrix protein binding;GO:0038023|signaling receptor activity;GO:0005102|receptor binding;","K06591","ITGB8; integrin beta 8"]
["gene4975",614,76,217,251.574605530093,94,79,102,100.945453049776,2.49218362917289,1.31741037299149,0.000172224545801567,0.00452378295136175,"up","yes","RAPGEF5","protein_coding","chrNC_037331.1:30908102-31143277:-","gi|803284450|ref|XP_012001890.1|",4093,0,"PREDICTED: rap guanine nucleotide exchange factor 5 isoform X5 [Ovis aries musimon]","gi|982980304|ref|XM_005198033.3|",6684,0,"PREDICTED: Bos taurus Rap guanine nucleotide exchange factor 5 (RAPGEF5), transcript variant X1, mRNA","Q8C0Q9",1419,0,"Rap guanine nucleotide exchange factor 5",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0007264|small GTPase mediated signal transduction;","GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0030742|GTP-dependent protein binding;GO:0017034|Rap guanyl-nucleotide exchange factor activity;","K08019","RAPGEF5; Rap guanine nucleotide exchange factor 5"]
["gene4992",669,152,93,252.732344608381,81,63,81,82.6342361160232,3.05844594791837,1.61279877947302,{"v":5.60910642705964e-06,"d":"5.61E-06"},0.000261065930620618,"up","yes","GPNMB","protein_coding","chrNC_037331.1:31876899-31903133:+","gi|84000107|ref|NP_001033154.1|",2763,0,"transmembrane glycoprotein NMB precursor [Bos taurus]","gi|84000106|ref|NM_001038065.1|",2797,0,"Bos taurus glycoprotein (transmembrane) nmb (GPNMB), mRNA","Q14956",838,0,"Transmembrane glycoprotein NMB",".",".",".",".","pfam00801","PKD","PKD domain. This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.","GO:0030282|bone mineralization;GO:0007155|cell adhesion;GO:0007267|cell-cell signaling;GO:0008285|negative regulation of cell proliferation;GO:0001818|negative regulation of cytokine production;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;GO:1901215|negative regulation of neuron death;GO:0050868|negative regulation of T cell activation;GO:0042130|negative regulation of T cell proliferation;GO:0032720|negative regulation of tumor necrosis factor production;GO:0001649|osteoblast differentiation;GO:0050918|positive chemotaxis;GO:0030335|positive regulation of cell migration;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0031954|positive regulation of protein autophosphorylation;GO:0001934|positive regulation of protein phosphorylation;GO:0045765|regulation of angiogenesis;GO:0034103|regulation of tissue remodeling;GO:0007165|signal transduction;","GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0042470|melanosome;GO:0005886|plasma membrane;","GO:0042056|chemoattractant activity;GO:0008201|heparin binding;GO:0005178|integrin binding;GO:0048018|receptor agonist activity;GO:0045545|syndecan binding;",".","."]
["gene504",91,62,92,72.2904009548493,15,27,25,24.5395079268193,2.94587818021578,1.55869777238586,0.00194477682243929,0.0301884806969615,"up","yes","MUC4","protein_coding","chrNC_037328.1:70482404-70510339:-","gi|982976175|ref|XP_015317525.1|",6353,0,"PREDICTED: mucin-4 isoform X2 [Bos taurus]","gi|594111465|ref|XM_006078488.1|",4598,0,"PREDICTED: Bubalus bubalis mucin 4, cell surface associated (MUC4), transcript variant X2, mRNA","Q99102",1622,0,"Mucin-4",".",".",".",".","pfam03782","AMOP","AMOP domain. This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.","GO:0007160|cell-matrix adhesion;GO:0030277|maintenance of gastrointestinal epithelium;GO:0016266|O-glycan processing;GO:0002223|stimulatory C-type lectin receptor signaling pathway;","GO:0070062|extracellular exosome;GO:0031012|extracellular matrix;GO:0005615|extracellular space;GO:0005796|Golgi lumen;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0031982|vesicle;","GO:0005176|ErbB-2 class receptor binding;GO:0030197|extracellular matrix constituent, lubricant activity;",".","."]
["gene506",2259,3204,2604,2438.50007010642,343,554,441,490.702611961447,4.96940511557335,2.31307315798883,{"v":5.44907389562565e-14,"d":"5.45E-14"},{"v":1.61945340954266e-11,"d":"1.62E-11"},"up","yes","TNK2","protein_coding","chrNC_037328.1:70600188-70625939:-","gi|741913716|ref|XP_010799458.1|",4643,0,"PREDICTED: activated CDC42 kinase 1 isoform X1 [Bos taurus]","gi|982910375|ref|XM_010801163.2|",3528,0,"PREDICTED: Bos taurus tyrosine kinase, non-receptor, 2 (TNK2), transcript variant X11, mRNA","Q17R13",1732,0,"Activated CDC42 kinase 1",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0030154|cell differentiation;GO:0016477|cell migration;GO:0006897|endocytosis;GO:0045087|innate immune response;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0016310|phosphorylation;GO:0042127|regulation of cell proliferation;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;","GO:0005912|adherens junction;GO:0005905|coated pit;GO:0030136|clathrin-coated vesicle;GO:0005737|cytoplasm;GO:0030659|cytoplasmic vesicle membrane;GO:0005768|endosome;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004715|non-membrane spanning protein tyrosine kinase activity;GO:0004674|protein serine/threonine kinase activity;GO:0004712|protein serine/threonine/tyrosine kinase activity;GO:0005102|receptor binding;","K08886","TNK2, ACK1; activated CDC42 kinase 1 [EC:2.7.10.2 2.7.11.1]"]
["gene5075",2044,2463,2415,2081.58128514262,931,723,823,910.390791538513,2.28647005713321,1.19312202620445,{"v":1.51358267111698e-06,"d":"1.51E-06"},{"v":8.72404589689669e-05,"d":"8.72E-05"},"up","yes","PMPCB","protein_coding","chrNC_037331.1:44517271-44531443:+","gi|296488545|tpg|DAA30658.1|",2548,0,"TPA: mitochondrial-processing peptidase subunit beta precursor [Bos taurus]","gi|77736172|ref|NM_001034613.1|",1586,0,"Bos taurus peptidase (mitochondrial processing) beta (PMPCB), mRNA","Q3SZ71",981,0,"Mitochondrial-processing peptidase subunit beta","SPBP23A10.15c",445,{"v":2e-150,"d":"2.00E-150"},"COG0612","pfam00675","Peptidase_M16","Insulinase (Peptidase family M16).","GO:0009060|aerobic respiration;GO:0006122|mitochondrial electron transport, ubiquinol to cytochrome c;GO:0016485|protein processing;GO:0006627|protein processing involved in protein targeting to mitochondrion;","GO:0017087|mitochondrial processing peptidase complex;GO:0005750|mitochondrial respiratory chain complex III;","GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K17732","PMPCB, MAS1; mitochondrial-processing peptidase subunit beta [EC:3.4.24.64]"]
["gene508",16113,18004,13240,14165.9417405486,2626,1687,2155,2378.51960832743,5.95578093657594,2.5742906901981,{"v":1.14431813198178e-16,"d":"1.14E-16"},{"v":5.10133447243315e-14,"d":"5.10E-14"},"up","yes","TFRC","protein_coding","chrNC_037328.1:70650067-70724638:-","gi|742094424|ref|XP_010832624.1|",3964,0,"PREDICTED: transferrin receptor protein 1 isoform X1 [Bison bison bison]","gi|742094431|ref|XM_010834324.1|",5841,0,"PREDICTED: Bison bison bison transferrin receptor (TFRC), transcript variant X3, mRNA","Q8HZV3",1286,0,"Transferrin receptor protein 1",".",".",".",".","pfam04253","TFR_dimer","Transferrin receptor-like dimerization domain. This domain is involved in dimerization of the transferrin receptor as shown in its crystal structure.","GO:0006879|cellular iron ion homeostasis;GO:0030890|positive regulation of B cell proliferation;GO:0045830|positive regulation of isotype switching;GO:0042102|positive regulation of T cell proliferation;GO:0031623|receptor internalization;GO:0033572|transferrin transport;","GO:0016021|integral component of membrane;GO:0042470|melanosome;GO:0005886|plasma membrane;","GO:0004998|transferrin receptor activity;GO:0033570|transferrin transmembrane transporter activity;","K06503","TFRC, CD71; transferrin receptor"]
["gene5082",90,24,89,58.6551410073383,1,2,1,1.46871611661701,39.9363364667383,5.3196300890692,{"v":4.05947591833879e-12,"d":"4.06E-12"},{"v":8.9783649167538e-10,"d":"8.98E-10"},"up","yes","LHFPL3","protein_coding","chrNC_037331.1:45537726-46118813:+","gi|528946407|ref|XP_005205401.1|",1031,{"v":1e-128,"d":"1.00E-128"},"PREDICTED: lipoma HMGIC fusion partner-like 3 protein isoform X1 [Bos taurus]","gi|982921319|ref|XM_005205344.3|",3040,0,"PREDICTED: Bos taurus lipoma HMGIC fusion partner-like 3 (LHFPL3), transcript variant X1, mRNA","Q86UP9",391,{"v":2e-126,"d":"2.00E-126"},"LHFPL tetraspan subfamily member 3 protein",".",".",".",".","pfam10242","L_HGMIC_fpl","Lipoma HMGIC fusion partner-like protein. This is a group of proteins expressed from a series of genes referred to as Lipoma HGMIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene5105",556,913,615,632.992565465534,115,89,105,113.547377298913,5.57470001089662,2.47889417195018,{"v":6.08069103383659e-18,"d":"6.08E-18"},{"v":3.33631145935369e-15,"d":"3.34E-15"},"up","yes","CCDC71L","protein_coding","chrNC_037331.1:47810139-47815184:-","gi|965912130|ref|XP_014946823.1|",640,{"v":7e-72,"d":"7.00E-72"},"PREDICTED: coiled-coil domain-containing protein 71L [Ovis aries musimon]","gi|965912129|ref|XM_015091337.1|",3828,0,"PREDICTED: Ovis aries musimon coiled-coil domain-containing protein 71L (LOC105614113), mRNA","Q8N9Z2",228,{"v":3e-65,"d":"3.00E-65"},"Coiled-coil domain-containing protein 71L",".",".",".",".","pfam15374","CCDC71L","Coiled-coil domain-containing protein 71L. The protein family, Coiled-coil domain-containing protein 71L, is a domain of unknown function, which is found in eukaryotes.","GO:0044255|cellular lipid metabolic process;GO:0045600|positive regulation of fat cell differentiation;",".",".",".","."]
["gene5211",0,33,0,10.8146834138175,1,0,0,0.373768090184884,28.9342073275116,4.85470421591509,0.00177791722273033,0.0282594742516541,"up","yes","DPY19L2","protein_coding","chrNC_037331.1:61850757-61940801:+","gi|332164745|ref|NP_001193711.1|",3825,0,"probable C-mannosyltransferase DPY19L2 [Bos taurus]","gi|332164744|ref|NM_001206782.1|",2467,0,"Bos taurus dpy-19 like 2 (C. elegans) (DPY19L2), mRNA","Q6NUT2",1190,0,"Probable C-mannosyltransferase DPY19L2",".",".",".",".","pfam10034","Dpy19","Q-cell neuroblast polarisation. Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants. The Dpy-19 protein derives from the C. elegans DUMPY mutant.","GO:0007275|multicellular organismal development;GO:0018406|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan;GO:0007286|spermatid development;","GO:0016021|integral component of membrane;GO:0005637|nuclear inner membrane;GO:0005634|nucleus;","GO:0000030|mannosyltransferase activity;",".","."]
["gene5217",106,100,213,125.814738983823,21,25,31,28.2139786606692,4.45930510180795,2.15681891097879,{"v":7.04565766584059e-07,"d":"7.05E-07"},{"v":4.4870459567879e-05,"d":"4.49E-05"},"up","yes","BMPER","protein_coding","chrNC_037331.1:62664281-62917005:-","gi|118151088|ref|NP_001071465.1|",3621,0,"BMP-binding endothelial regulator protein precursor [Bos taurus]","gi|118151087|ref|NM_001077997.1|",3342,0,"Bos taurus BMP binding endothelial regulator (BMPER), mRNA","Q8N8U9",1337,0,"BMP-binding endothelial regulator protein",".",".",".",".","pfam00094","VWD","von Willebrand factor type D domain. Luciferin-2-monooxygenase from Vargula hilgendorfii contains a vwd domain. Its function is unrelated but the similarity is very strong by several methods.","GO:0002043|blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0042118|endothelial cell activation;GO:0048839|inner ear development;GO:0030514|negative regulation of BMP signaling pathway;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:1903672|positive regulation of sprouting angiogenesis;GO:0010594|regulation of endothelial cell migration;GO:0060393|regulation of pathway-restricted SMAD protein phosphorylation;GO:0001657|ureteric bud development;","GO:0005615|extracellular space;",".",".","."]
["gene5226",1845,2987,2586,2253.95912426345,833,957,890,983.821793370292,2.29102378037594,1.19599243361089,{"v":1.65480955811226e-06,"d":"1.65E-06"},{"v":9.44267430050018e-05,"d":"9.44E-05"},"up","yes","KBTBD2","protein_coding","chrNC_037331.1:63906668-63926884:+","gi|528946728|ref|XP_005205529.1|",3211,0,"PREDICTED: kelch repeat and BTB domain-containing protein 2 isoform X1 [Bos taurus]","gi|982921625|ref|XM_005205472.3|",3707,0,"PREDICTED: Bos taurus kelch repeat and BTB (POZ) domain containing 2 (KBTBD2), transcript variant X1, mRNA","Q8IY47",1226,0,"Kelch repeat and BTB domain-containing protein 2",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0016567|protein ubiquitination;","GO:0031463|Cul3-RING ubiquitin ligase complex;",".","K10470","KBTBD2; kelch repeat and BTB domain-containing protein 2"]
["gene5276",21,8,0,8.09482940721317,0,0,0,0,"Inf","Inf",0.00155813254548703,0.025681732903114,"up","yes","HOXA11","protein_coding","chrNC_037331.1:68857317-68861039:+","gi|741876263|ref|XP_010825652.1|",1359,{"v":1e-179,"d":"1.00E-179"},"PREDICTED: homeobox protein Hox-A11 isoform X1 [Bos taurus]","gi|982980686|ref|XM_010827350.2|",2289,0,"PREDICTED: Bos taurus homeobox A11 (HOXA11), transcript variant X1, mRNA","P31270",507,{"v":5e-173,"d":"5.00E-173"},"Homeobox protein Hox-A11",".",".",".",".","pfam12045","DUF3528","Protein of unknown function (DUF3528). This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.","GO:0009653|anatomical structure morphogenesis;GO:0009952|anterior/posterior pattern specification;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0048589|developmental growth;GO:0009953|dorsal/ventral pattern formation;GO:0042733|embryonic digit morphogenesis;GO:0035115|embryonic forelimb morphogenesis;GO:0030326|embryonic limb morphogenesis;GO:0060272|embryonic skeletal joint morphogenesis;GO:0008584|male gonad development;GO:0007501|mesodermal cell fate specification;GO:0001656|metanephros development;GO:0007275|multicellular organismal development;GO:0001759|organ induction;GO:0010720|positive regulation of cell development;GO:0032332|positive regulation of chondrocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0009954|proximal/distal pattern formation;GO:0007338|single fertilization;GO:0001501|skeletal system development;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;GO:0060065|uterus development;","GO:0005654|nucleoplasm;GO:0032991|macromolecular complex;GO:0032993|protein-DNA complex;GO:0005667|transcription factor complex;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;",".","."]
["gene5277",327,259,0,170.102677359948,0,0,0,0,"Inf","Inf",{"v":1.43279109710621e-34,"d":"1.43E-34"},{"v":3.71626934468521e-31,"d":"3.72E-31"},"up","yes","HOXA10","protein_coding","chrNC_037331.1:68862754-68872133:+","gi|507537641|ref|XP_004652844.1|",542,{"v":5e-73,"d":"5.00E-73"},"PREDICTED: homeobox protein Hox-A10 isoform X2 [Jaculus jaculus]","gi|157279942|ref|NM_001105017.1|",1781,0,"Bos taurus homeobox A10 (HOXA10), mRNA","P31260",201,{"v":4e-56,"d":"4.00E-56"},"Homeobox protein Hox-A10",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009952|anterior/posterior pattern specification;GO:0030326|embryonic limb morphogenesis;GO:0008584|male gonad development;GO:0007275|multicellular organismal development;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0009954|proximal/distal pattern formation;GO:0007338|single fertilization;GO:0001501|skeletal system development;GO:0007283|spermatogenesis;GO:0060065|uterus development;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0042826|histone deacetylase binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K17443","HOXA10; homrobox protein Hox-A10"]
["gene5280",995,219,1,331.397414031882,7,9,12,10.2509394136381,32.3284921176085,5.01473431298603,{"v":4.43339070416503e-35,"d":"4.43E-35"},{"v":1.26489070180533e-31,"d":"1.26E-31"},"up","yes","HOXA9","protein_coding","chrNC_037331.1:68877182-68880322:+","gi|332801060|ref|NP_001099087.2|",1178,{"v":3e-154,"d":"3.00E-154"},"homeobox protein Hox-A9 [Bos taurus]","gi|332801059|ref|NM_001105617.2|",2060,0,"Bos taurus homeobox A9 (HOXA9), mRNA","P31269",437,{"v":8e-148,"d":"8.00E-148"},"Homeobox protein Hox-A9",".",".",".",".","pfam04617","Hox9_act","Hox9 activation region. This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.","GO:0042118|endothelial cell activation;GO:0007275|multicellular organismal development;GO:0045638|negative regulation of myeloid cell differentiation;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0019899|enzyme binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;",".","."]
["gene533",340,550,662,472.171145536501,120,228,199,200.358941353974,2.35662627455351,1.23672298701476,0.0017225886713338,0.027657387384257,"up","yes","PIGZ","protein_coding","chrNC_037328.1:71415004-71440636:-","gi|982910776|ref|XP_015327498.1|",2600,0,"PREDICTED: LOW QUALITY PROTEIN: GPI mannosyltransferase 4 [Bos taurus]","gi|742094547|ref|XM_010834356.1|",2235,0,"PREDICTED: Bison bison bison phosphatidylinositol glycan anchor biosynthesis, class Z (PIGZ), transcript variant X5, mRNA","Q86VD9",736,0,"GPI mannosyltransferase 4",".",".",".",".","pfam03901","Glyco_transf_22","Alg9-like mannosyltransferase family. Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.","GO:0006506|GPI anchor biosynthetic process;GO:0016254|preassembly of GPI anchor in ER membrane;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0000026|alpha-1,2-mannosyltransferase activity;GO:0000030|mannosyltransferase activity;","K08098","PIGZ, SMP3; phosphatidylinositol glycan, class Z [EC:2.4.1.-]"]
["gene5354",48,194,189,134.133133886148,8,12,7,9.92080576852509,13.5203870548197,3.75706454784445,{"v":9.14168581366483e-15,"d":"9.14E-15"},{"v":3.06848750529025e-12,"d":"3.07E-12"},"up","yes","ADCY1","protein_coding","chrNC_037331.1:76174089-76273756:-","gi|27806331|ref|NP_776654.1|",5026,0,"adenylate cyclase type 1 [Bos taurus]","gi|31342545|ref|NM_174229.2|",3972,0,"Bos taurus adenylate cyclase 1 (brain) (ADCY1), mRNA","P19754",1940,0,"Adenylate cyclase type 1","all0661",150,{"v":4e-37,"d":"4.00E-37"},"COG2114","pfam00211","Guanylate_cyc","Adenylate and Guanylate cyclase catalytic domain.","GO:0007189|adenylate cyclase-activating G-protein coupled receptor signaling pathway;GO:0006171|cAMP biosynthetic process;GO:0019933|cAMP-mediated signaling;GO:0071277|cellular response to calcium ion;GO:1904322|cellular response to forskolin;GO:0006182|cGMP biosynthetic process;GO:0042752|regulation of circadian rhythm;GO:0048511|rhythmic process;","GO:0005737|cytoplasm;GO:0008074|guanylate cyclase complex, soluble;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;","GO:0005524|ATP binding;GO:0008294|calcium- and calmodulin-responsive adenylate cyclase activity;GO:0005516|calmodulin binding;GO:0004383|guanylate cyclase activity;GO:0046872|metal ion binding;","K08041","ADCY1; adenylate cyclase 1 [EC:4.6.1.1]"]
["gene5489",0,28,0,9.17609501778457,0,0,0,0,"Inf","Inf",0.00104682693358169,0.0187168424671039,"up","yes","FSCN3","protein_coding","chrNC_037331.1:91824112-91832363:+","gi|803253891|ref|XP_011986907.1|",3010,0,"PREDICTED: fascin-3 isoform X1 [Ovis aries musimon]","gi|982980979|ref|XM_015463123.1|",1758,0,"PREDICTED: Bos taurus fascin actin-bundling protein 3 (FSCN3), mRNA","Q9QXW4",756,0,"Fascin-3",".",".",".",".","pfam06268","Fascin","Fascin domain. This family consists of several eukaryotic fascin or singed proteins. The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture.  Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerization and binding to microfilaments only at pH values below seven. Members of this family are histidine rich, typically contain the repeated motif of HHXH.","GO:0030036|actin cytoskeleton organization;GO:0051017|actin filament bundle assembly;GO:0009653|anatomical structure morphogenesis;GO:0016477|cell migration;GO:0007163|establishment or maintenance of cell polarity;GO:0007286|spermatid development;","GO:0015629|actin cytoskeleton;GO:0031253|cell projection membrane;GO:0005737|cytoplasm;GO:0031941|filamentous actin;GO:0030175|filopodium;GO:0030426|growth cone;GO:0030027|lamellipodium;GO:0005902|microvillus;GO:0001726|ruffle;","GO:0003779|actin binding;GO:0051015|actin filament binding;GO:0030674|protein binding, bridging;","K17456","FSCN3; fascin 3"]
["gene551",319,433,491,375.837289748784,122,186,166,173.780894317831,2.16270776614492,1.11283873565742,0.00029331839943365,0.00688212767618541,"up","yes","XXYLT1","protein_coding","chrNC_037328.1:72326778-72499172:+","gi|115496384|ref|NP_001069467.1|",1840,0,"xyloside xylosyltransferase 1 [Bos taurus]","gi|115496383|ref|NM_001075999.1|",2358,0,"Bos taurus xyloside xylosyltransferase 1 (XXYLT1), mRNA","Q8NBI6",661,0,"Xyloside xylosyltransferase 1",".",".",".",".","pfam01501","Glyco_transf_8","Glycosyl transferase family 8. This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.","GO:0016266|O-glycan processing;","GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0000287|magnesium ion binding;GO:0030145|manganese ion binding;GO:0035252|UDP-xylosyltransferase activity;",".","."]
["gene5539",141,28,54,62.5085396265279,21,13,17,18.7565073944504,3.33263215330923,1.7366620855599,0.00107866239455553,0.0191746521987937,"up","yes","CPA5","protein_coding","chrNC_037331.1:94063807-94118097:+","gi|555986977|ref|XP_005905343.1|",2068,0,"PREDICTED: carboxypeptidase A5 isoform X1 [Bos mutus]","gi|965932945|ref|XM_004008065.3|",2256,0,"PREDICTED: Ovis aries carboxypeptidase A5 (LOC101116902), transcript variant X2, mRNA","Q4R7R2",577,0,"Carboxypeptidase A5","YHR132c",120,{"v":7e-34,"d":"7.00E-34"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.",".","GO:0005576|extracellular region;","GO:0004181|metallocarboxypeptidase activity;GO:0008270|zinc ion binding;","K08781","CPA5; carboxypeptidase A5 [EC:3.4.17.1]"]
["gene554",982,579,493,597.09152020257,237,226,213,248.409453205972,2.40365860677404,1.26523200366584,{"v":4.93581319207989e-06,"d":"4.94E-06"},0.000233151798316608,"up","yes","FAM43A","protein_coding","chrNC_037328.1:72860629-72863781:-","gi|61858592|ref|XP_586734.1|",1797,0,"PREDICTED: protein FAM43A [Bos taurus]","gi|982910812|ref|XM_002684829.4|",3129,0,"PREDICTED: Bos taurus family with sequence similarity 43 member A (FAM43A), mRNA",".",".",".",".",".",".",".",".","pfam14719","PID_2","Phosphotyrosine interaction domain (PTB/PID).",".",".",".",".","."]
["gene5562",11923,4178,5383,6129.8510702357,1644,1616,1743,1836.70239632489,3.33742204643555,1.73873413956146,{"v":1.22837948159526e-11,"d":"1.23E-11"},{"v":2.35214060331506e-09,"d":"2.35E-09"},"up","yes","PODXL","protein_coding","chrNC_037331.1:95244825-95294315:-","gi|594046715|ref|XP_006047792.1|",1980,0,"PREDICTED: podocalyxin-like [Bubalus bubalis]","gi|982980983|ref|XM_868371.8|",5612,0,"PREDICTED: Bos taurus podocalyxin-like (PODXL), mRNA","Q52S86",330,{"v":2e-96,"d":"2.00E-96"},"Podocalyxin",".",".",".",".","pfam06365","CD34_antigen","CD34/Podocalyxin family. This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteristic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.","GO:0007155|cell adhesion;GO:0016477|cell migration;GO:0072175|epithelial tube formation;GO:0072015|glomerular visceral epithelial cell development;GO:0007162|negative regulation of cell adhesion;GO:0022408|negative regulation of cell-cell adhesion;GO:0030335|positive regulation of cell migration;GO:0033634|positive regulation of cell-cell adhesion mediated by integrin;GO:0032534|regulation of microvillus assembly;","GO:0016324|apical plasma membrane;GO:0005737|cytoplasm;GO:0030175|filopodium;GO:0016021|integral component of membrane;GO:0030027|lamellipodium;GO:0045121|membrane raft;GO:0031528|microvillus membrane;GO:0005886|plasma membrane;GO:0001726|ruffle;GO:0036057|slit diaphragm;",".","K06817","PODXL; podocalyxin-like"]
["gene5580",100,284,143,163.052538184252,26,47,37,40.3223829600808,4.04372277168425,2.01568409278345,{"v":6.48764695642531e-07,"d":"6.49E-07"},{"v":4.18776143243825e-05,"d":"4.19E-05"},"up","yes","BPGM","protein_coding","chrNC_037331.1:98321779-98353161:+","gi|440898660|gb|ELR50106.1|",1405,0,"hypothetical protein M91_16189 [Bos mutus]","gi|402692474|ref|NM_001035402.2|",1374,0,"Bos taurus bisphosphoglycerate mutase (BPGM), mRNA","Q3T014",531,0,"Bisphosphoglycerate mutase","XF1893",256,{"v":4e-81,"d":"4.00E-81"},"COG0588","pfam00300","His_Phos_1","Histidine phosphatase superfamily (branch 1). The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.","GO:0006094|gluconeogenesis;GO:0006096|glycolytic process;GO:0043456|regulation of pentose-phosphate shunt;","GO:0005829|cytosol;","GO:0046538|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity;GO:0004082|bisphosphoglycerate mutase activity;GO:0016787|hydrolase activity;","K01837","BPGM; bisphosphoglycerate mutase [EC:5.4.2.4 5.4.2.11 3.1.3.13]"]
["gene56",41,85,71,60.3471914290202,7,1,3,4.06628286564336,14.8408739438426,3.89150414623443,{"v":9.59414352060891e-05,"d":"9.59E-05"},0.00281037483353689,"up","yes","C1H21orf62","protein_coding","chrNC_037328.1:2749168-2768577:+","gi|254911045|ref|NP_001157166.1|",1097,{"v":2e-144,"d":"2.00E-144"},"uncharacterized protein C21orf62 homolog precursor [Bos taurus]","gi|982909365|ref|XM_005201104.3|",1700,0,"PREDICTED: Bos taurus chromosome 1 open reading frame, human C21orf62 (C1H21orf62), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam15137","DUF4571","Domain of unknown function (DUF4571). This family of proteins is functionally uncharacterized. This family of proteins is found in vertebrate. This family includes human protein C21orf62.",".",".",".",".","."]
["gene5665",0,45,0,14.7472955642966,0,0,0,0,"Inf","Inf",{"v":3.37191327560205e-05,"d":"3.37E-05"},0.00116610978989336,"up","yes","PRSS37","protein_coding","chrNC_037331.1:105071255-105077184:-","gi|965933331|ref|XP_014950897.1|",1349,0,"PREDICTED: probable inactive serine protease 37 isoform X2 [Ovis aries]","gi|402766046|ref|NM_001040569.2|",925,0,"Bos taurus protease, serine 37 (PRSS37), mRNA","Q32KU2",494,{"v":4e-176,"d":"4.00E-176"},"Probable inactive serine protease 37",".",".",".",".","pfam00089","Trypsin","Trypsin.","GO:0007339|binding of sperm to zona pellucida;GO:0016477|cell migration;GO:2000344|positive regulation of acrosome reaction;GO:0051604|protein maturation;GO:0070613|regulation of protein processing;","GO:0001669|acrosomal vesicle;GO:0005576|extracellular region;","GO:0004252|serine-type endopeptidase activity;",".","."]
["gene569",538,1604,1451,1111.50794923061,215,441,349,368.181195384276,3.01891558603505,1.59403041723205,0.00048932874176061,0.0104109159814854,"up","yes","HES1","protein_coding","chrNC_037328.1:73362774-73365254:-","gi|641720379|ref|XP_008149834.1|",1140,{"v":2e-151,"d":"2.00E-151"},"PREDICTED: transcription factor HES-1 [Eptesicus fuscus]","gi|77736300|ref|NM_001034678.1|",1434,0,"Bos taurus hes family bHLH transcription factor 1 (HES1), mRNA","Q3ZBG4",443,{"v":9e-153,"d":"9.00E-153"},"Transcription factor HES-1",".",".",".",".","pfam07527","Hairy_orange","Hairy Orange. The Orange domain is found in the Drosophila proteins Hesr-1, Hairy, and Enhancer of Split. The Orange domain is proposed to mediate specific protein-protein interaction between Hairy and Scute.","GO:0021861|forebrain radial glial cell differentiation;GO:2000978|negative regulation of forebrain neuron differentiation;GO:0060253|negative regulation of glial cell proliferation;GO:0048715|negative regulation of oligodendrocyte differentiation;GO:2000974|negative regulation of pro-B cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048711|positive regulation of astrocyte differentiation;GO:0043388|positive regulation of DNA binding;GO:0046427|positive regulation of JAK-STAT cascade;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0065003|macromolecular complex assembly;GO:0046425|regulation of JAK-STAT cascade;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0071820|N-box binding;GO:0042803|protein homodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K06054","HES1; hairy and enhancer of split 1"]
["gene5748",0,49,0,16.058166281123,0,0,0,0,"Inf","Inf",{"v":1.53524845940951e-05,"d":"1.54E-05"},0.00061090897901552,"up","yes","LLCFC1","protein_coding","chrNC_037331.1:106251295-106252641:+","gi|982922342|ref|XP_005228669.3|",540,{"v":3e-66,"d":"3.00E-66"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein C7orf34 homolog [Bos taurus]","gi|965908940|ref|XM_015090800.1|",672,0,"PREDICTED: Ovis aries musimon chromosome 4 open reading frame, human C7orf34 (C4H7orf34), transcript variant X2, mRNA","Q96L11",122,{"v":4e-33,"d":"4.00E-33"},"LLLL and CFNLAS motif-containing protein 1",".",".",".",".","pfam02956","TT_ORF1","TT viral orf 1. TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF1 is a large 750 residue protein. The N-terminal half of this protein corresponds to the capsid protein.",".","GO:0005576|extracellular region;",".",".","."]
["gene5766",2226,4926,3485,3264.80350609331,737,1407,1086,1183.83514889463,2.75781937133875,1.4635279678716,0.000454266549198582,0.00981126337258497,"up","yes","CLCN1","protein_coding","chrNC_037331.1:106700961-106737587:+","gi|219804896|ref|NP_001137343.1|",4785,0,"chloride channel protein 1 [Bos taurus]","gi|219804895|ref|NM_001143871.1|",3124,0,"Bos taurus chloride channel, voltage-sensitive 1 (CLCN1), mRNA","P35523",1625,0,"Chloride channel protein 1","SPBC19C7.11_1",137,{"v":8e-33,"d":"8.00E-33"},"COG0038","pfam00654","Voltage_CLC","Voltage gated chloride channel. This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney. These proteins contain two pfam00571 domains.","GO:1902476|chloride transmembrane transport;GO:0034220|ion transmembrane transport;GO:0006936|muscle contraction;GO:0019227|neuronal action potential propagation;GO:0034765|regulation of ion transmembrane transport;","GO:0034707|chloride channel complex;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0042383|sarcolemma;","GO:0042803|protein homodimerization activity;GO:0005247|voltage-gated chloride channel activity;","K05010","CLCN1; chloride channel 1, skeletal muscle"]
["gene5855",179,238,202,186.686937033687,88,64,87,87.7834376470263,2.12667607965351,1.08860030886745,0.00268874144706524,0.0381844112624283,"up","yes","ZBED6CL","protein_coding","chrNC_037331.1:112741052-112748067:+","gi|982923769|ref|XP_005205996.2|",1410,{"v":3e-176,"d":"3.00E-176"},"PREDICTED: LOW QUALITY PROTEIN: ZBED6 C-terminal-like protein [Bos taurus]","gi|982981191|ref|XM_005198149.3|",5536,0,"PREDICTED: Bos taurus ZBED6 C-terminal like (ZBED6CL), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam09502","HrpB4","Bacterial type III secretion protein (HrpB4). This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow range of species including Xanthomonas, Burkholderia and Ralstonia.",".",".",".",".","."]
["gene5857",2262,3993,3059,2837.59153200261,1252,1053,1286,1318.60669360823,2.15196202609728,1.10565262006716,{"v":1.32573647265634e-05,"d":"1.33E-05"},0.000542677005758366,"up","yes","REPIN1","protein_coding","chrNC_037331.1:112781775-112787915:+","gi|965857468|ref|XP_014963738.1|",2684,0,"PREDICTED: replication initiator 1 isoform X2 [Ovis aries musimon]","gi|115495954|ref|NM_001075521.1|",2914,0,"Bos taurus replication initiator 1 (REPIN1), mRNA","Q0VCC5",971,0,"Replication initiator 1",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006260|DNA replication;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["gene5880",236,58,92,108.769899579274,32,35,29,35.2733575656908,3.08362761828691,1.62462855458891,0.000212435907844856,0.00529345754298829,"up","yes","TMEM176B","protein_coding","chrNC_037331.1:113400402-113408319:-","gi|982922318|ref|XP_010802885.2|",1404,0,"PREDICTED: transmembrane protein 176B isoform X1 [Bos taurus]","gi|402745121|ref|NM_001099145.2|",1151,0,"Bos taurus transmembrane protein 176B (TMEM176B), mRNA","Q5R8D6",298,{"v":2e-97,"d":"2.00E-97"},"Transmembrane protein 176B",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.","GO:0030154|cell differentiation;","GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;",".",".","."]
["gene5881",725,100,137,263.799278431222,54,40,69,59.7701089328352,4.41356529444606,2.1419445411647,{"v":2.4677390240067e-09,"d":"2.47E-09"},{"v":2.94590217966255e-07,"d":"2.95E-07"},"up","yes","TMEM176A","protein_coding","chrNC_037331.1:113409627-113413255:+","gi|45429975|ref|NP_991348.1|",722,{"v":4e-91,"d":"4.00E-91"},"transmembrane protein 176A [Bos taurus]","gi|126717462|gb|BC133443.1|",973,0,"Bos taurus transmembrane protein 176A, mRNA (cDNA clone MGC:148300 IMAGE:7950630), complete cds","Q7YQI4",282,{"v":1e-92,"d":"1.00E-92"},"Transmembrane protein 176A",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene5885",953,734,725,711.581905608422,175,188,178,198.656252897047,3.58197587657709,1.84075562128261,{"v":1.87363374742655e-11,"d":"1.87E-11"},{"v":3.54017512899516e-09,"d":"3.54E-09"},"up","yes","NOS3","protein_coding","chrNC_037331.1:113577075-113595527:+","gi|317008623|ref|NP_851380.2|",5647,0,"nitric oxide synthase, endothelial [Bos taurus]","gi|317008622|ref|NM_181037.3|",4075,0,"Bos taurus nitric oxide synthase 3 (endothelial cell) (NOS3), mRNA","P29473",2180,0,"Nitric oxide synthase, endothelial","BH0823",311,{"v":4e-94,"d":"4.00E-94"},"COG4362","pfam02898","NO_synthase","Nitric oxide synthase, oxygenase domain.","GO:0006527|arginine catabolic process;GO:0007596|blood coagulation;GO:0071499|cellular response to laminar fluid shear stress;GO:0007005|mitochondrion organization;GO:0045776|negative regulation of blood pressure;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1903038|negative regulation of leukocyte cell-cell adhesion;GO:0006809|nitric oxide biosynthetic process;GO:0007263|nitric oxide mediated signal transduction;GO:0031284|positive regulation of guanylate cyclase activity;","GO:0005901|caveola;GO:0005856|cytoskeleton;GO:0005794|Golgi apparatus;","GO:0005516|calmodulin binding;GO:0050660|flavin adenine dinucleotide binding;GO:0010181|FMN binding;GO:0020037|heme binding;GO:0046872|metal ion binding;GO:0050661|NADP binding;GO:0003958|NADPH-hemoprotein reductase activity;GO:0004517|nitric-oxide synthase activity;",".","."]
["gene5947",21,10,11,12.1286027353155,1,0,1,0.734740978638126,16.5073176642418,4.04503380527252,0.00182549294096423,0.028755939036774,"up","yes","PTPRN2","protein_coding","chrNC_037331.1:118732042-119330088:-","gi|741876920|ref|XP_010825814.1|",4067,0,"PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Bos taurus]","gi|982981331|ref|XM_010827512.2|",4677,0,"PREDICTED: Bos taurus protein tyrosine phosphatase, receptor type N2 (PTPRN2), mRNA","Q92932",1063,0,"Receptor-type tyrosine-protein phosphatase N2","SPAC26F1.10c",125,{"v":1e-28,"d":"1.00E-28"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0035773|insulin secretion involved in cellular response to glucose stimulus;GO:0006629|lipid metabolic process;GO:0034260|negative regulation of GTPase activity;GO:0007269|neurotransmitter secretion;GO:0043312|neutrophil degranulation;GO:0006470|protein dephosphorylation;","GO:0030054|cell junction;GO:0005788|endoplasmic reticulum lumen;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0043235|receptor complex;GO:0030667|secretory granule membrane;GO:0030672|synaptic vesicle membrane;GO:0043195|terminal bouton;","GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;","K07817","PTPRN; receptor-type tyrosine-protein phosphatase N [EC:3.1.3.48]"]
["gene602",36,58,28,36.9894676611128,3,6,4,4.76712123830428,7.75928821862109,2.95592431599957,{"v":4.56807255062969e-05,"d":"4.57E-05"},0.00148950489076589,"up","yes","TPRG1","protein_coding","chrNC_037328.1:78014339-78169293:-","gi|741914034|ref|XP_010799559.1|",1436,0,"PREDICTED: tumor protein p63-regulated gene 1 protein isoform X1 [Bos taurus]","gi|594091271|ref|XM_006068957.1|",1424,0,"PREDICTED: Bubalus bubalis tumor protein p63 regulated 1 (TPRG1), transcript variant X3, mRNA","Q6ZUI0",481,{"v":5e-166,"d":"5.00E-166"},"Tumor protein p63-regulated gene 1 protein",".",".",".",".","pfam12456","hSac2","Inositol phosphatase. This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with pfam02383. hSac2 functions as an inositol polyphosphate 5-phosphatase.",".","GO:0005737|cytoplasm;",".",".","."]
["gene6025",141,253,300,211.796939315604,87,75,112,100.470855027056,2.10804356406212,1.07590468149456,0.00231742273771869,0.0342937697768942,"up","yes","MYF5","protein_coding","chrNC_037332.1:10284434-10287669:+","gi|440912223|gb|ELR61811.1|",1187,{"v":4e-156,"d":"4.00E-156"},"Myogenic factor 5, partial [Bos mutus]","gi|27806530|ref|NM_174116.1|",1977,0,"Bos taurus myogenic factor 5 (MYF5), mRNA","P17667",449,{"v":6e-153,"d":"6.00E-153"},"Myogenic factor 5",".",".",".",".","pfam01586","Basic","Myogenic Basic domain. This basic domain is found in the MyoD family of muscle specific proteins that control muscle development. The bHLH region of the MyoD family includes the basic domain and the Helix-loop-helix (HLH) motif. The bHLH region mediates specific DNA binding. With 12 residues of the basic domain involved in DNA binding. The basic domain forms an extended alpha helix in the structure.","GO:0043010|camera-type eye development;GO:0001502|cartilage condensation;GO:0048704|embryonic skeletal system morphogenesis;GO:0030198|extracellular matrix organization;GO:0060415|muscle tissue morphogenesis;GO:0001503|ossification;GO:0045663|positive regulation of myoblast differentiation;GO:1901741|positive regulation of myoblast fusion;GO:0048743|positive regulation of skeletal muscle fiber development;GO:0001952|regulation of cell-matrix adhesion;GO:0035914|skeletal muscle cell differentiation;GO:0001756|somitogenesis;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0046983|protein dimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K18484","MYF5; myogenic factor 5"]
["gene6089",205,120,278,178.133699199267,16,19,22,20.8944567997289,8.52540465189687,3.09176831219313,{"v":6.92225589565496e-14,"d":"6.92E-14"},{"v":1.99493821170638e-11,"d":"1.99E-11"},"up","yes","KERA","protein_coding","chrNC_037332.1:20929212-20936988:-","gi|953889312|ref|XP_001492790.2|",1782,0,"PREDICTED: keratocan isoform X1 [Equus caballus]","gi|555996838|ref|XM_005910091.1|",2074,0,"PREDICTED: Bos mutus keratocan (KERA), mRNA","O62702",684,0,"Keratocan","alr0124_1",62.8,{"v":2e-09,"d":"2.00E-09"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.",".","GO:0005615|extracellular space;",".","K08123","KERA; keratocan"]
["gene6111",301,97,124,148.319291738144,51,56,57,60.1889311046727,2.46422870477972,1.30113615860574,0.000733086645654871,0.0142866769721169,"up","yes","SOCS2","protein_coding","chrNC_037332.1:23366264-23372592:+","gi|548464669|ref|XP_005679877.1|",1170,{"v":8e-151,"d":"8.00E-151"},"PREDICTED: suppressor of cytokine signaling 2 isoform X1 [Capra hircus]","gi|982924562|ref|XM_010804824.2|",2424,0,"PREDICTED: Bos taurus suppressor of cytokine signaling 2 (SOCS2), transcript variant X1, mRNA","Q861R0",371,{"v":8e-122,"d":"8.00E-122"},"Suppressor of cytokine signaling 2",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0019221|cytokine-mediated signaling pathway;GO:0060396|growth hormone receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0007595|lactation;GO:0060749|mammary gland alveolus development;GO:0046627|negative regulation of insulin receptor signaling pathway;GO:0046426|negative regulation of JAK-STAT cascade;GO:0040015|negative regulation of multicellular organism growth;GO:0006469|negative regulation of protein kinase activity;GO:0045666|positive regulation of neuron differentiation;GO:0016567|protein ubiquitination;GO:0001558|regulation of cell growth;GO:0032355|response to estradiol;","GO:0005737|cytoplasm;","GO:0005131|growth hormone receptor binding;GO:0005159|insulin-like growth factor receptor binding;GO:0008269|JAK pathway signal transduction adaptor activity;GO:0004860|protein kinase inhibitor activity;","K04695","SOCS2, CIS2; suppressor of cytokine signaling 2"]
["gene6119",124,148,190,139.172608275805,35,38,54,46.5199467545449,2.99167600105234,1.58095393960202,0.000101664775003247,0.00293285914622613,"up","yes","TMCC3","protein_coding","chrNC_037332.1:24240322-24595453:-","gi|528948394|ref|XP_005206162.1|",2336,0,"PREDICTED: transmembrane and coiled-coil domains protein 3 isoform X2 [Bos taurus]","gi|982924574|ref|XM_015470918.1|",2516,0,"PREDICTED: Bos taurus transmembrane and coiled-coil domain family 3 (TMCC3), transcript variant X3, mRNA","Q9ULS5",847,0,"Transmembrane and coiled-coil domain protein 3",".",".",".",".","pfam10267","Tmemb_cc2","Predicted transmembrane and coiled-coil 2 protein. This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene6148",53,22,96,50.506497321242,8,4,3,5.54101366279657,9.11502847580981,3.1882471633237,{"v":1.08036496271957e-06,"d":"1.08E-06"},{"v":6.55392029281563e-05,"d":"6.55E-05"},"up","yes","NFE2","protein_coding","chrNC_037332.1:25770431-25777486:+","gi|741925650|ref|XP_010803151.1|",1296,{"v":1e-162,"d":"1.00E-162"},"PREDICTED: transcription factor NF-E2 45 kDa subunit isoform X1 [Bos taurus]","gi|982924696|ref|XM_005206154.3|",3990,0,"PREDICTED: Bos taurus nuclear factor, erythroid 2 (NFE2), transcript variant X7, mRNA","Q5EAD3",483,{"v":6e-157,"d":"6.00E-157"},"Transcription factor NF-E2 45 kDa subunit",".",".",".",".","pfam03131","bZIP_Maf","bZIP Maf transcription factor. Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.","GO:0045893|positive regulation of transcription, DNA-templated;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0032993|protein-DNA complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0047485|protein N-terminus binding;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0000976|transcription regulatory region sequence-specific DNA binding;GO:0050699|WW domain binding;","K09039","NFE2; nuclear factor erythroid 2"]
["gene6163",239,185,7,125.066575692331,16,18,42,27.7469269998043,4.50740277268229,2.17229637221625,0.00279681201728445,0.0391924575958462,"up","yes","HOXC9","protein_coding","chrNC_037332.1:26029600-26037612:-","gi|148671999|gb|EDL03946.1|",1338,{"v":3e-166,"d":"3.00E-166"},"homeobox C9, isoform CRA_b, partial [Mus musculus]","gi|965872564|ref|XM_012149321.2|",3833,0,"PREDICTED: Ovis aries musimon homeobox C10 (HOXC10), transcript variant X2, mRNA","P09633",511,{"v":1e-164,"d":"1.00E-164"},"Homeobox protein Hox-C9",".",".",".",".","pfam04617","Hox9_act","Hox9 activation region. This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.","GO:0009952|anterior/posterior pattern specification;GO:0048706|embryonic skeletal system development;GO:0048704|embryonic skeletal system morphogenesis;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0016235|aggresome;GO:0005654|nucleoplasm;","GO:0043565|sequence-specific DNA binding;","K09294","HOX_9; homeobox protein HoxA/B/C/D9"]
["gene6165",1289,3447,4,1466.81467904143,0,3,1,1.46193559542157,1003.33741351885,9.97059113782104,{"v":2.97864678089174e-12,"d":"2.98E-12"},{"v":6.85352994400178e-10,"d":"6.85E-10"},"up","yes","HOXC10","protein_coding","chrNC_037332.1:26042721-26047450:-","gi|742194353|ref|XP_010856256.1|",1895,0,"PREDICTED: homeobox protein Hox-C10 isoform X1 [Bison bison bison]","gi|982981579|ref|XM_015463272.1|",1686,0,"PREDICTED: Bos taurus homeobox C10 (HOXC10), transcript variant X1, mRNA","Q9NYD6",634,0,"Homeobox protein Hox-C10",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009952|anterior/posterior pattern specification;GO:0030326|embryonic limb morphogenesis;GO:0050905|neuromuscular process;GO:0008284|positive regulation of cell proliferation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0009954|proximal/distal pattern formation;GO:0001501|skeletal system development;GO:0021520|spinal cord motor neuron cell fate specification;","GO:0016604|nuclear body;GO:0005654|nucleoplasm;","GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K17444","HOXC10; homrobox protein Hox-C10"]
["gene6167",52,107,0,48.6181999905883,0,0,0,0,"Inf","Inf",{"v":4.00085337934668e-13,"d":"4.00E-13"},{"v":1.04723254831321e-10,"d":"1.05E-10"},"up","yes","HOXC11","protein_coding","chrNC_037332.1:26057080-26059552:-","gi|7657166|ref|NP_055027.1|",1394,0,"homeobox protein Hox-C11 [Homo sapiens]","gi|300797720|ref|NM_001192873.1|",1199,0,"Bos taurus homeobox C11 (HOXC11), mRNA","O43248",541,0,"Homeobox protein Hox-C11",".",".",".",".","pfam12045","DUF3528","Protein of unknown function (DUF3528). This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.","GO:0009952|anterior/posterior pattern specification;GO:0042733|embryonic digit morphogenesis;GO:0060272|embryonic skeletal joint morphogenesis;GO:0007492|endoderm development;GO:0001656|metanephros development;GO:0001759|organ induction;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0009954|proximal/distal pattern formation;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09296","HOX_11; homeobox protein HoxA/C/D11"]
["gene6248",5688,11387,10626,8477.62066296952,1642,3211,2447,2675.42494615377,3.16870061152605,1.66389135594265,{"v":7.91402582762485e-05,"d":"7.91E-05"},0.00239697527481916,"up","yes","NR4A1","protein_coding","chrNC_037332.1:27822914-27839686:-","gi|440896105|gb|ELR48130.1|",2534,0,"Nuclear receptor subfamily 4 group A member 1, partial [Bos mutus]","gi|982924825|ref|XM_005206219.3|",2606,0,"PREDICTED: Bos taurus nuclear receptor subfamily 4 group A member 1 (NR4A1), transcript variant X1, mRNA","Q0V8F0",976,0,"Nuclear receptor subfamily 4 group A member 1",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0071376|cellular response to corticotropin-releasing hormone stimulus;GO:0045444|fat cell differentiation;GO:0045786|negative regulation of cell cycle;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0061469|regulation of type B pancreatic cell proliferation;","GO:0005829|cytosol;GO:0031965|nuclear membrane;","GO:0004879|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0046982|protein heterodimerization activity;GO:0043565|sequence-specific DNA binding;GO:0003707|steroid hormone receptor activity;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0008270|zinc ion binding;","K04465","NR4A1, HMR; nuclear receptor subfamily 4 group A member 1"]
["gene6251",1406,1252,1490,1234.35003943444,626,426,594,604.733424586466,2.04114737047737,1.0293803484566,0.000182732705144934,0.00469930391962991,"up","yes","ACVRL1","protein_coding","chrNC_037332.1:27943335-27957082:-","gi|803288690|ref|XP_012004006.1|",2455,0,"PREDICTED: serine/threonine-protein kinase receptor R3 isoform X2 [Ovis aries musimon]","gi|982924832|ref|XM_010804911.2|",2580,0,"PREDICTED: Bos taurus activin A receptor type IL (ACVRL1), transcript variant X1, mRNA","P37023",853,0,"Serine/threonine-protein kinase receptor R3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0001525|angiogenesis;GO:0060840|artery development;GO:0008015|blood circulation;GO:0002043|blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0001955|blood vessel maturation;GO:0001974|blood vessel remodeling;GO:0030509|BMP signaling pathway;GO:0071773|cellular response to BMP stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0035912|dorsal aorta morphogenesis;GO:0003203|endocardial cushion morphogenesis;GO:0061154|endothelial tube morphogenesis;GO:0001701|in utero embryonic development;GO:0001946|lymphangiogenesis;GO:0060836|lymphatic endothelial cell differentiation;GO:0043537|negative regulation of blood vessel endothelial cell migration;GO:0007162|negative regulation of cell adhesion;GO:0030308|negative regulation of cell growth;GO:0030336|negative regulation of cell migration;GO:0008285|negative regulation of cell proliferation;GO:2000279|negative regulation of DNA biosynthetic process;GO:0045602|negative regulation of endothelial cell differentiation;GO:0010596|negative regulation of endothelial cell migration;GO:0001937|negative regulation of endothelial cell proliferation;GO:0051895|negative regulation of focal adhesion assembly;GO:0010629|negative regulation of gene expression;GO:0045766|positive regulation of angiogenesis;GO:0030513|positive regulation of BMP signaling pathway;GO:0032332|positive regulation of chondrocyte differentiation;GO:0045603|positive regulation of endothelial cell differentiation;GO:0001938|positive regulation of endothelial cell proliferation;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006468|protein phosphorylation;GO:0008217|regulation of blood pressure;GO:0043535|regulation of blood vessel endothelial cell migration;GO:0006275|regulation of DNA replication;GO:0001936|regulation of endothelial cell proliferation;GO:0006355|regulation of transcription, DNA-templated;GO:0001666|response to hypoxia;GO:0061298|retina vasculature development in camera-type eye;GO:0007165|signal transduction;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0060841|venous blood vessel development;GO:0035313|wound healing, spreading of epidermal cells;","GO:0009986|cell surface;GO:0030425|dendrite;GO:0005887|integral component of plasma membrane;GO:0043025|neuronal cell body;GO:0005886|plasma membrane;","GO:0048185|activin binding;GO:0016361|activin receptor activity, type I;GO:0005524|ATP binding;GO:0098821|BMP receptor activity;GO:0046872|metal ion binding;GO:0019901|protein kinase binding;GO:0004674|protein serine/threonine kinase activity;GO:0046332|SMAD binding;GO:0050431|transforming growth factor beta binding;GO:0005025|transforming growth factor beta receptor activity, type I;GO:0005024|transforming growth factor beta-activated receptor activity;GO:0004675|transmembrane receptor protein serine/threonine kinase activity;","K13594","ACVRL1, ALK1; activin receptor-like kinase 1 [EC:2.7.11.30]"]
["gene6259",89,39,44,49.4898094462364,14,13,6,12.1694289901706,4.06673225886029,2.02387001132387,0.000617095453503275,0.0124956354747352,"up","yes","SLC4A8","protein_coding","chrNC_037332.1:28302577-28414816:-","gi|859914937|ref|XP_004774774.2|",5753,0,"PREDICTED: electroneutral sodium bicarbonate exchanger 1 isoform X1 [Mustela putorius furo]","gi|741877329|ref|XM_618089.8|",8694,0,"PREDICTED: Bos taurus solute carrier family 4, sodium bicarbonate cotransporter, member 8 (SLC4A8), transcript variant X1, mRNA","Q2Y0W8",2155,0,"Electroneutral sodium bicarbonate exchanger 1",".",".",".",".","pfam00955","HCO3_cotransp","HCO3- transporter family. This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.","GO:0015701|bicarbonate transport;GO:0051453|regulation of intracellular pH;","GO:0005887|integral component of plasma membrane;GO:0043005|neuron projection;GO:0032809|neuronal cell body membrane;GO:0005886|plasma membrane;","GO:0015301|anion:anion antiporter activity;GO:0005452|inorganic anion exchanger activity;GO:0008510|sodium:bicarbonate symporter activity;","K13859","SLC4A8; solute carrier family 4 (sodium bicarbonate cotransporter), member 8"]
["gene6302",7434,17377,16539,12711.7079524577,2599,4727,3708,4044.66097538824,3.14283645274806,1.65206719897459,{"v":2.2862684601494e-05,"d":"2.29E-05"},0.000849342779121388,"up","yes","GPD1","protein_coding","chrNC_037332.1:29789222-29794805:-","gi|440909092|gb|ELR59039.1|",1808,0,"Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic, partial [Bos mutus]","gi|555959943|ref|XM_005892017.1|",1620,0,"PREDICTED: Bos mutus glycerol-3-phosphate dehydrogenase 1 (soluble) (GPD1), transcript variant X1, mRNA","Q5EA88",674,0,"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic","SPBC215.05",318,{"v":6e-102,"d":"6.00E-102"},"COG0240","pfam07479","NAD_Gly3P_dh_C","NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus. NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.","GO:0005975|carbohydrate metabolic process;GO:0071320|cellular response to cAMP;GO:0071356|cellular response to tumor necrosis factor;GO:0006094|gluconeogenesis;GO:0046168|glycerol-3-phosphate catabolic process;GO:0006072|glycerol-3-phosphate metabolic process;GO:0006127|glycerophosphate shuttle;GO:0045821|positive regulation of glycolytic process;","GO:0005829|cytosol;GO:0009331|glycerol-3-phosphate dehydrogenase complex;","GO:0004367|glycerol-3-phosphate dehydrogenase [NAD+] activity;GO:0004368|glycerol-3-phosphate dehydrogenase activity;GO:0051287|NAD binding;GO:0042803|protein homodimerization activity;","K00006","GPD1; glycerol-3-phosphate dehydrogenase (NAD+) [EC:1.1.1.8]"]
["gene6315",12614,20357,14098,14288.6510956676,5099,7516,5853,6776.89637649421,2.10843582398987,1.0761731099165,0.00017007797440549,0.00448480493430952,"up","yes","TMBIM6","protein_coding","chrNC_037332.1:30112133-30128722:-","gi|942056230|ref|XP_014333912.1|",1090,{"v":4e-137,"d":"4.00E-137"},"PREDICTED: LOW QUALITY PROTEIN: bax inhibitor 1 [Bos mutus]","gi|942056229|ref|XM_014478426.1|",2797,0,"PREDICTED: Bos mutus transmembrane BAX inhibitor motif containing 6 (TMBIM6), mRNA","Q0V882",362,{"v":5e-116,"d":"5.00E-116"},"Bax inhibitor 1",".",".",".",".","pfam01027","Bax1-I","Inhibitor of apoptosis-promoting Bax1. Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner.","GO:0006914|autophagy;GO:0032469|endoplasmic reticulum calcium ion homeostasis;GO:0070059|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:0010523|negative regulation of calcium ion transport into cytosol;GO:1902236|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;GO:1903298|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway;GO:0051025|negative regulation of immunoglobulin secretion;GO:0032091|negative regulation of protein binding;GO:1990441|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress;GO:1902065|response to L-glutamate;GO:0006986|response to unfolded protein;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0060698|endoribonuclease inhibitor activity;GO:0031625|ubiquitin protein ligase binding;",".","."]
["gene6340",7621,10916,8650,8220.178004858,3014,3501,3518,3681.26312442779,2.23297757509135,1.15896876281872,{"v":1.19562200435733e-05,"d":"1.20E-05"},0.000500180225899104,"up","yes","KMT2D","protein_coding","chrNC_037332.1:30759459-30799358:+","gi|296487853|tpg|DAA29966.1|",10578,0,"TPA: myeloid/lymphoid or mixed-lineage leukemia 2-like [Bos taurus]","gi|982981707|ref|XM_010827687.2|",12530,0,"PREDICTED: Bos taurus lysine (K)-specific methyltransferase 2D (KMT2D), mRNA","O14686",3653,0,"Histone-lysine N-methyltransferase 2D","SPCC306.04c",135,{"v":2e-30,"d":"2.00E-30"},"COG2940","pfam00856","SET","SET domain. SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.","GO:0006342|chromatin silencing;GO:0051568|histone H3-K4 methylation;GO:0001555|oocyte growth;GO:0048477|oogenesis;GO:0008284|positive regulation of cell proliferation;GO:0033148|positive regulation of intracellular estrogen receptor signaling pathway;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045652|regulation of megakaryocyte differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0043627|response to estrogen;GO:0006351|transcription, DNA-templated;","GO:0035097|histone methyltransferase complex;GO:0044666|MLL3/4 complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0042800|histone methyltransferase activity (H3-K4 specific);GO:0018024|histone-lysine N-methyltransferase activity;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0044212|transcription regulatory region DNA binding;","K09187","MLL2, ALR; histone-lysine N-methyltransferase MLL2 [EC:2.1.1.43]"]
["gene6350",223,76,142,126.636797406527,48,51,53,55.7887974353579,2.26993237402652,1.18264931729158,0.00323919134787293,0.0436905119898886,"up","yes","RND1","protein_coding","chrNC_037332.1:30923453-30930386:+","gi|114051103|ref|NP_001039481.1|",1188,{"v":2e-158,"d":"2.00E-158"},"rho-related GTP-binding protein Rho6 precursor [Bos taurus]","gi|114051102|ref|NM_001046016.1|",1624,0,"Bos taurus Rho family GTPase 1 (RND1), mRNA","Q2HJ68",462,{"v":8e-160,"d":"8.00E-160"},"Rho-related GTP-binding protein Rho6",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007015|actin filament organization;GO:0007162|negative regulation of cell adhesion;GO:0016322|neuron remodeling;GO:0007264|small GTPase mediated signal transduction;","GO:0015629|actin cytoskeleton;GO:0005912|adherens junction;GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;GO:0005886|plasma membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0005102|receptor binding;","K07531","RND1; Rho family GTPase 1"]
["gene6379",0,27,0,8.84837733857797,0,0,0,0,"Inf","Inf",0.00128721883969803,0.0220839691614097,"up","yes","C5H12orf54","protein_coding","chrNC_037332.1:31543719-31568121:-","gi|116004203|ref|NP_001070460.1|",747,{"v":1e-97,"d":"1.00E-97"},"uncharacterized protein C12orf54 homolog [Bos taurus]","gi|116004202|ref|NM_001076992.1|",742,0,"Bos taurus chromosome 5 open reading frame, human C12orf54 (C5H12orf54), mRNA",".",".",".",".",".",".",".",".","pfam03846","SulA","Cell division inhibitor SulA.",".",".",".",".","."]
["gene6400",41923,99575,64739,63441.3433030358,10675,20309,14576,16704.6657234247,3.79782177946087,1.92517220566624,{"v":8.00065370068376e-06,"d":"8.00E-06"},0.000357784719019135,"up","yes","PFKM","protein_coding","chrNC_037332.1:32145678-32189038:-","gi|555987351|ref|XP_005905527.1|",4129,0,"PREDICTED: ATP-dependent 6-phosphofructokinase, muscle type isoform X2 [Bos mutus]","gi|741926169|ref|XM_010805037.1|",2756,0,"PREDICTED: Bos taurus phosphofructokinase, muscle (PFKM), transcript variant X1, mRNA","Q0IIG5",1583,0,"ATP-dependent 6-phosphofructokinase, muscle type","SPBC16H5.02",638,0,"COG0205","pfam00365","PFK","Phosphofructokinase.","GO:0061621|canonical glycolysis;GO:0006002|fructose 6-phosphate metabolic process;GO:0042593|glucose homeostasis;GO:0005980|glycogen catabolic process;GO:0093001|glycolysis from storage polysaccharide through glucose-1-phosphate;GO:0046716|muscle cell cellular homeostasis;GO:0032024|positive regulation of insulin secretion;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051259|protein oligomerization;","GO:0005945|6-phosphofructokinase complex;GO:0016324|apical plasma membrane;GO:0005634|nucleus;GO:0097228|sperm principal piece;","GO:0003872|6-phosphofructokinase activity;GO:0005524|ATP binding;GO:0070061|fructose binding;GO:0019900|kinase binding;GO:0046872|metal ion binding;GO:0008022|protein C-terminus binding;GO:0042803|protein homodimerization activity;","K00850","pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]"]
["gene6407",2157,1802,2076,1790.29609115641,686,713,720,777.967526242638,2.30124784231423,1.2024163688825,{"v":1.26883275535273e-06,"d":"1.27E-06"},{"v":7.52620942681265e-05,"d":"7.53E-05"},"up","yes","HDAC7","protein_coding","chrNC_037332.1:32462215-32499017:+","gi|528949021|ref|XP_005206430.1|",4385,0,"PREDICTED: histone deacetylase 7 isoform X4 [Bos taurus]","gi|982925206|ref|XM_005206373.3|",4629,0,"PREDICTED: Bos taurus histone deacetylase 7 (HDAC7), transcript variant X4, mRNA","Q8WUI4",1490,0,"Histone deacetylase 7","YNL021w",241,{"v":1e-65,"d":"1.00E-65"},"COG0123","pfam00850","Hist_deacetyl","Histone deacetylase domain. Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyse the removal of the acetyl group. Histone deacetylases are related to other proteins.","GO:0007043|cell-cell junction assembly;GO:0032703|negative regulation of interleukin-2 production;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:0045668|negative regulation of osteoblast differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0006351|transcription, DNA-templated;GO:0001570|vasculogenesis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0000118|histone deacetylase complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0071889|14-3-3 protein binding;GO:0033613|activating transcription factor binding;GO:0003682|chromatin binding;GO:0046872|metal ion binding;GO:0032041|NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0019901|protein kinase binding;GO:0005080|protein kinase C binding;GO:0070491|repressing transcription factor binding;GO:0019789|SUMO transferase activity;GO:0003714|transcription corepressor activity;","K11408","HDAC7; histone deacetylase 7 [EC:3.5.1.98]"]
["gene6480",60,66,86,63.6792215281045,11,14,14,14.3028953962313,4.45219095602723,2.15451547170176,{"v":9.52145496938805e-05,"d":"9.52E-05"},0.00279194893865992,"up","yes","PTPRR","protein_coding","chrNC_037332.1:42611742-42884729:+","gi|164448636|ref|NP_001106732.1|",3447,0,"receptor-type tyrosine-protein phosphatase R isoform 2 precursor [Bos taurus]","gi|164448635|ref|NM_001113261.1|",3211,0,"Bos taurus protein tyrosine phosphatase, receptor type R (PTPRR), transcript variant 2, mRNA","Q15256",1246,0,"Receptor-type tyrosine-protein phosphatase R","SPAC11E3.09",122,{"v":4e-29,"d":"4.00E-29"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0038128|ERBB2 signaling pathway;GO:0001701|in utero embryonic development;GO:0010633|negative regulation of epithelial cell migration;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0006470|protein dephosphorylation;","GO:0030054|cell junction;GO:0005829|cytosol;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0019901|protein kinase binding;GO:0004725|protein tyrosine phosphatase activity;GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;","K04458","PTPRR; receptor-type tyrosine-protein phosphatase R [EC:3.1.3.48]"]
["gene6483",13176,4632,7362,7212.9895252617,2579,3206,2643,3094.56139494889,2.33086004919311,1.22086238396209,{"v":2.89147617156907e-06,"d":"2.89E-06"},0.000148375371674527,"up","yes","PTPRB","protein_coding","chrNC_037332.1:42885405-43015906:+","gi|528949191|ref|XP_005206489.1|",10492,0,"PREDICTED: receptor-type tyrosine-protein phosphatase beta isoform X2 [Bos taurus]","gi|982925377|ref|XM_005206432.3|",11456,0,"PREDICTED: Bos taurus protein tyrosine phosphatase, receptor type B (PTPRB), transcript variant X2, mRNA","P23467",3586,0,"Receptor-type tyrosine-protein phosphatase beta","SPAC11E3.09",161,{"v":3e-41,"d":"3.00E-41"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0001525|angiogenesis;GO:0016311|dephosphorylation;GO:0043312|neutrophil degranulation;GO:0006796|phosphate-containing compound metabolic process;GO:0006470|protein dephosphorylation;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0043235|receptor complex;GO:0035579|specific granule membrane;GO:0070821|tertiary granule membrane;","GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;","K05694","PTPRB, PTPB; receptor-type tyrosine-protein phosphatase beta [EC:3.1.3.48]"]
["gene6619",659,137,178,271.315685908609,72,87,98,94.214564063811,2.8797637457076,1.52595045858531,{"v":1.04618383395495e-05,"d":"1.05E-05"},0.000447189732282794,"up","yes","SLC26A10","protein_coding","chrNC_037332.1:55863893-55871532:-","gi|375281043|ref|NP_001015530.2|",3089,0,"solute carrier family 26 member 10 [Bos taurus]","gi|594110245|ref|XM_006077901.1|",2319,0,"PREDICTED: Bubalus bubalis solute carrier family 26, member 10 (SLC26A10), transcript variant X1, mRNA","Q8NG04",709,0,"Solute carrier family 26 member 10","aq_1268",162,{"v":6e-41,"d":"6.00E-41"},"COG0659","pfam00916","Sulfate_transp","Sulfate transporter family. Mutations in human SLC26A2 lead to several human diseases.","GO:0015701|bicarbonate transport;GO:1902476|chloride transmembrane transport;GO:0051453|regulation of intracellular pH;GO:0042391|regulation of membrane potential;","GO:0005887|integral component of plasma membrane;","GO:0015301|anion:anion antiporter activity;GO:0015106|bicarbonate transmembrane transporter activity;GO:0005254|chloride channel activity;GO:0019531|oxalate transmembrane transporter activity;GO:0008271|secondary active sulfate transmembrane transporter activity;GO:0015116|sulfate transmembrane transporter activity;","K14707","SLC26A10; solute carrier family 26, member 10"]
["gene6704",10192,12693,19705,12867.8243222516,4717,5809,5762,5974.82065292936,2.1536754104816,1.10680083160206,{"v":9.38992587400924e-05,"d":"9.39E-05"},0.0027648116295038,"up","yes","ZC3H10","protein_coding","chrNC_037332.1:57197913-57205251:-","gi|297262666|ref|XP_001114150.2|",2020,0,"PREDICTED: zinc finger CCCH domain-containing protein 10 isoform X1 [Macaca mulatta]","gi|965898140|ref|XM_012160701.2|",3581,0,"PREDICTED: Ovis aries musimon zinc finger CCCH-type containing 10 (ZC3H10), transcript variant X2, mRNA","Q96K80",660,0,"Zinc finger CCCH domain-containing protein 10",".",".",".",".","pfam00642","zf-CCCH","Zinc finger C-x8-C-x5-C-x3-H type (and similar).","GO:1903799|negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:0010608|posttranscriptional regulation of gene expression;","GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0035198|miRNA binding;GO:0003723|RNA binding;",".","."]
["gene6713",341,359,376,322.000904832961,108,154,127,142.726596197904,2.2560679888034,1.17381054541025,0.000211754599391181,0.00528109307275331,"up","yes","DGKA","protein_coding","chrNC_037332.1:57353450-57375995:-","gi|741926527|ref|XP_010803431.1|",3949,0,"PREDICTED: diacylglycerol kinase alpha isoform X1 [Bos taurus]","gi|982925596|ref|XM_010805131.2|",2759,0,"PREDICTED: Bos taurus diacylglycerol kinase alpha (DGKA), transcript variant X4, mRNA","A0JN54",1439,0,"Diacylglycerol kinase alpha",".",".",".",".","pfam00609","DAGK_acc","Diacylglycerol kinase accessory domain. Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. This domain is assumed to be an accessory domain: its function is unknown.","GO:0046339|diacylglycerol metabolic process;GO:0035556|intracellular signal transduction;GO:0046834|lipid phosphorylation;GO:0006654|phosphatidic acid biosynthetic process;GO:0007205|protein kinase C-activating G-protein coupled receptor signaling pathway;","GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0005509|calcium ion binding;GO:0004143|diacylglycerol kinase activity;GO:0003951|NAD+ kinase activity;GO:0005543|phospholipid binding;","K00901","dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]"]
["gene6724",96,116,86,89.4475420145377,29,25,18,26.5114758322561,3.3739178678883,1.75442485417305,0.000209126031870317,0.00523383755727369,"up","yes","RDH5","protein_coding","chrNC_037332.1:57533652-57538050:-","gi|942085008|ref|XP_014336969.1|",1552,0,"PREDICTED: 11-cis retinol dehydrogenase isoform X1 [Bos mutus]","gi|982925541|ref|XM_010805117.2|",1367,0,"PREDICTED: Bos taurus retinol dehydrogenase 5 (RDH5), transcript variant X2, mRNA","Q27979",591,0,"11-cis retinol dehydrogenase",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0050896|response to stimulus;GO:0042572|retinol metabolic process;GO:0007601|visual perception;","GO:0005788|endoplasmic reticulum lumen;GO:0016020|membrane;","GO:0016491|oxidoreductase activity;","K00061","RDH5; 11-cis-retinol dehydrogenase [EC:1.1.1.315]"]
["gene6725",1062,2391,2803,1921.21678750653,588,813,794,804.749004049004,2.38734907137522,1.25540952859917,{"v":1.20846663047456e-06,"d":"1.21E-06"},{"v":7.19807128059908e-05,"d":"7.20E-05"},"up","yes","BLOC1S1","protein_coding","chrNC_037332.1:57538200-57541849:-","gi|545825725|ref|XP_003126301.2|",586,{"v":5e-74,"d":"5.00E-74"},"PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 1, partial [Sus scrofa]","gi|402744490|ref|NM_001076362.2|",558,0,"Bos taurus biogenesis of lysosomal organelles complex 1 subunit 1 (BLOC1S1), mRNA","Q5R7L8",226,{"v":5e-74,"d":"5.00E-74"},"Biogenesis of lysosome-related organelles complex 1 subunit 1",".",".",".",".","pfam06320","GCN5L1","GCN5-like protein 1 (GCN5L1). This family consists of several eukaryotic GCN5-like protein 1 (GCN5L1) sequences. The function of this family is unknown.","GO:0009060|aerobic respiration;GO:0008089|anterograde axon cargo transport;GO:0048490|anterograde synaptic vesicle transport;GO:0032418|lysosome localization;GO:0031175|neuron projection development;GO:0018394|peptidyl-lysine acetylation;","GO:1904115|axon cytoplasm;GO:0031083|BLOC-1 complex;GO:0005829|cytosol;GO:0005769|early endosome;GO:0005765|lysosomal membrane;GO:0005758|mitochondrial intermembrane space;GO:0005759|mitochondrial matrix;",".",".","."]
["gene686",16219,3699,6692,7494.53394573711,998,2407,1588,1829.58457942585,4.09630362543228,2.03432265446655,0.000264134680013398,0.00629576153338536,"up","yes","ABCC5","protein_coding","chrNC_037328.1:83122814-83205233:+","gi|742185631|ref|XP_010853978.1|",6410,0,"PREDICTED: multidrug resistance-associated protein 5 isoform X1 [Bison bison bison]","gi|741914207|ref|XM_010801296.1|",9355,0,"PREDICTED: Bos taurus ATP binding cassette subfamily C member 5 (ABCC5), transcript variant X5, mRNA","O15440",2385,0,"Multidrug resistance-associated protein 5","YGR281w",624,0,"COG1132","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0030213|hyaluronan biosynthetic process;GO:0055085|transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0043225|anion transmembrane-transporting ATPase activity;GO:0008514|organic anion transmembrane transporter activity;","K05668","ABCC5; ATP-binding cassette, subfamily C (CFTR/MRP), member 5"]
["gene6862",1290,136,293,470.760218537983,130,151,175,167.175230120758,2.81596871855915,1.49363130775708,{"v":1.34116387220692e-06,"d":"1.34E-06"},{"v":7.8734046168592e-05,"d":"7.87E-05"},"up","yes","NTN4","protein_coding","chrNC_037332.1:60031675-60161816:-","gi|741926719|ref|XP_010803496.1|",3146,0,"PREDICTED: netrin-4 isoform X1 [Bos taurus]","gi|982925831|ref|XM_010805194.2|",3725,0,"PREDICTED: Bos taurus netrin 4 (NTN4), transcript variant X1, mRNA","Q9JI33",1123,0,"Netrin-4",".",".",".",".","pfam00055","Laminin_N","Laminin N-terminal (Domain VI).","GO:0016322|neuron remodeling;GO:0060668|regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling;","GO:0005604|basement membrane;GO:0005886|plasma membrane;","GO:0043237|laminin-1 binding;","K06845","NTN4; netrin 4"]
["gene6944",2649,1708,1449,1695.15199756212,530,610,541,617.245837534753,2.74631580235918,1.45749753236815,{"v":3.61319731145066e-09,"d":"3.61E-09"},{"v":4.20290713176414e-07,"d":"4.20E-07"},"up","yes","NT5DC3","protein_coding","chrNC_037332.1:67446964-67511357:-","gi|119892715|ref|XP_599179.3|",2798,0,"PREDICTED: 5'-nucleotidase domain-containing protein 3 isoform X1 [Bos taurus]","gi|982981934|ref|XM_599179.6|",3307,0,"PREDICTED: Bos taurus 5'-nucleotidase domain containing 3 (NT5DC3), transcript variant X1, mRNA","Q86UY8",1030,0,"5'-nucleotidase domain-containing protein 3",".",".",".",".","pfam05761","5_nucleotid","5' nucleotidase family. This family of eukaryotic proteins includes 5' nucleotidase enzymes, such as purine 5'-nucleotidase EC:3.1.3.5.",".","GO:0043235|receptor complex;","GO:0008253|5'-nucleotidase activity;GO:0046872|metal ion binding;",".","."]
["gene6981",266,1210,1383,890.613392118413,323,287,270,323.515205312063,2.75292591351101,1.46096578477964,{"v":1.17093436027927e-07,"d":"1.17E-07"},{"v":9.62764502395613e-06,"d":"9.63E-06"},"up","yes","BTBD11","protein_coding","chrNC_037332.1:70577529-70909798:+","gi|329664644|ref|NP_001192674.1|",5106,0,"ankyrin repeat and BTB/POZ domain-containing protein BTBD11 [Bos taurus]","gi|594092545|ref|XM_006069563.1|",2993,0,"PREDICTED: Bubalus bubalis BTB (POZ) domain containing 11 (BTBD11), transcript variant X1, mRNA","A6QL63",1511,0,"Ankyrin repeat and BTB/POZ domain-containing protein BTBD11","FN0178",62,{"v":6e-09,"d":"6.00E-09"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0030162|regulation of proteolysis;GO:0060395|SMAD protein signal transduction;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0019005|SCF ubiquitin ligase complex;","GO:0046982|protein heterodimerization activity;GO:0031625|ubiquitin protein ligase binding;","K10483","BTBD11; BTB/POZ domain-containing protein 11"]
["gene6991",10011,4319,6551,6036.46570222726,2512,2332,2572,2723.14272252955,2.21672762587336,1.14843151402919,{"v":5.63758294412021e-06,"d":"5.64E-06"},0.000261963972278003,"up","yes","TIMP3","protein_coding","chrNC_037332.1:71402333-71459972:+","gi|555972801|ref|XP_005898401.1|",1046,{"v":5e-135,"d":"5.00E-135"},"PREDICTED: metalloproteinase inhibitor 3 isoform X1 [Bos mutus]","gi|402745310|ref|NM_174473.4|",2131,0,"Bos taurus TIMP metallopeptidase inhibitor 3 (TIMP3), mRNA","P79121",405,{"v":6e-136,"d":"6.00E-136"},"Metalloproteinase inhibitor 3",".",".",".",".","pfam00965","TIMP","Tissue inhibitor of metalloproteinase. Members of this family are common in extracellular regions of vertebrate species","GO:0043086|negative regulation of catalytic activity;GO:0051045|negative regulation of membrane protein ectodomain proteolysis;GO:0010033|response to organic substance;","GO:0005615|extracellular space;","GO:0008191|metalloendopeptidase inhibitor activity;GO:0002020|protease binding;GO:0008270|zinc ion binding;","K16866","TIMP3; metalloproteinase inhibitor 3"]
["gene7008",408,76,106,163.795717411334,39,30,35,38.2206336827573,4.28553118116479,2.09947403396152,{"v":2.5339810852619e-07,"d":"2.53E-07"},{"v":1.85376959855403e-05,"d":"1.85E-05"},"up","yes","RASD2","protein_coding","chrNC_037332.1:73749045-73760337:+","gi|440904025|gb|ELR54596.1|",1701,0,"GTP-binding protein Rhes, partial [Bos mutus]","gi|125991897|ref|NM_001081594.1|",3030,0,"Bos taurus RASD family member 2 (RASD2), mRNA","Q96D21",550,0,"GTP-binding protein Rhes",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007626|locomotory behavior;GO:0031397|negative regulation of protein ubiquitination;GO:0051897|positive regulation of protein kinase B signaling;GO:0033235|positive regulation of protein sumoylation;GO:0043949|regulation of cAMP-mediated signaling;GO:0007165|signal transduction;GO:0001963|synaptic transmission, dopaminergic;","GO:0005886|plasma membrane;","GO:0031681|G-protein beta-subunit binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0031624|ubiquitin conjugating enzyme binding;","K07844","RASD2; RASD family, member 2"]
["gene7020",982,347,390,489.427490365007,190,234,233,240.997711288263,2.0308387484211,1.02207569207679,0.000494383418909746,0.0104716060318589,"up","yes","LOC518495","protein_coding","chrNC_037332.1:74427173-74472321:-","gi|359065692|ref|XP_003586146.1|",1398,{"v":6e-172,"d":"6.00E-172"},"PREDICTED: apolipoprotein L3-like [Bos taurus]","gi|982982060|ref|XM_015463398.1|",3123,0,"PREDICTED: Bos taurus apolipoprotein L3-like (LOC518495), transcript variant X3, mRNA","O95236",135,{"v":2e-31,"d":"2.00E-31"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006954|inflammatory response;GO:0042157|lipoprotein metabolic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;","GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0016020|membrane;","GO:0008289|lipid binding;GO:0005319|lipid transporter activity;","K14480","APOL; apolipoprotein L"]
["gene7024",7214,2096,2723,3403.32449446831,1257,1448,1240,1448.83087094113,2.34901434165161,1.23205552159468,{"v":1.72164247303937e-06,"d":"1.72E-06"},{"v":9.7460677377552e-05,"d":"9.75E-05"},"up","yes","LOC510193","protein_coding","chrNC_037332.1:74561375-74585376:+","gi|154152081|ref|NP_001093803.1|",1441,0,"apolipoprotein L, 3-like [Bos taurus]","gi|154152080|ref|NM_001100333.1|",3375,0,"Bos taurus apolipoprotein L, 3-like (LOC510193), mRNA","O95236",181,{"v":9e-48,"d":"9.00E-48"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006954|inflammatory response;GO:0042157|lipoprotein metabolic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;","GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0016020|membrane;","GO:0008289|lipid binding;GO:0005319|lipid transporter activity;","K14480","APOL; apolipoprotein L"]
["gene7054",225,53,84,101.807482509177,33,29,31,34.1671460188455,2.97968939088512,1.57516194894748,0.000439331929633694,0.00954651887614541,"up","yes","C1QTNF6","protein_coding","chrNC_037332.1:75616448-75623744:-","gi|156120393|ref|NP_001095342.1|",1166,{"v":7e-150,"d":"7.00E-150"},"complement C1q tumor necrosis factor-related protein 6 precursor [Bos taurus]","gi|402744030|ref|NM_001101872.2|",2698,0,"Bos taurus C1q and tumor necrosis factor related protein 6 (C1QTNF6), mRNA","Q3T1I2",348,{"v":9e-111,"d":"9.00E-111"},"Complement C1q tumor necrosis factor-related protein 6",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0070208|protein heterotrimerization;","GO:0005581|collagen trimer;GO:0005615|extracellular space;","GO:0042802|identical protein binding;","K19470","C1QTNF6; complement C1q tumor necrosis factor-related protein 6"]
["gene7156",295,903,1021,686.384107104107,236,238,224,256.410237716647,2.67689821286548,1.42056228257747,{"v":6.16102439283926e-07,"d":"6.16E-07"},{"v":4.04191483416287e-05,"d":"4.04E-05"},"up","yes","SPX","protein_coding","chrNC_037332.1:88663467-88673433:-","gi|115495291|ref|NP_001068875.1|",501,{"v":4e-57,"d":"4.00E-57"},"spexin precursor [Bos taurus]","gi|742186927|ref|XM_010856040.1|",1568,0,"PREDICTED: Bison bison bison spexin hormone (SPX), mRNA","Q0VC44",197,{"v":1e-58,"d":"1.00E-58"},"Spexin",".",".",".",".","pfam15171","Spexin","Neuropeptide secretory protein family, NPQ, spexin. Spexin, alternatively named NPQ, is a peptide hormone and is derived from a pro-hormone. This family of proteins has a role in inducing stomach wall contraction and is expressed in the submucosal layer of the mouse oesophagus and stomach. Spexin, like most peptide hormones, is a ligand for G-protein coupled receptors. Spexin is also thought to have a role in controlling arterial blood pressure as well as salt and water balance.","GO:0044539|long-chain fatty acid import;GO:0032099|negative regulation of appetite;GO:0010459|negative regulation of heart rate;GO:0035814|negative regulation of renal sodium excretion;GO:1904306|positive regulation of gastro-intestinal system smooth muscle contraction;GO:0003084|positive regulation of systemic arterial blood pressure;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051930|regulation of sensory perception of pain;","GO:0031045|dense core granule;GO:0005615|extracellular space;GO:0030133|transport vesicle;","GO:0005184|neuropeptide hormone activity;GO:0031765|type 2 galanin receptor binding;GO:0031766|type 3 galanin receptor binding;",".","."]
["gene7200",311,86,76,132.578791222044,51,48,46,53.2823287797715,2.48823191962993,1.31512096043095,0.00143152741702635,0.0239829176366288,"up","yes","RERG","protein_coding","chrNC_037332.1:94669471-94799481:+","gi|115495785|ref|NP_001069666.1|",1058,{"v":1e-135,"d":"1.00E-135"},"ras-related and estrogen-regulated growth inhibitor [Bos taurus]","gi|402692319|ref|NM_001076198.2|",2474,0,"Bos taurus RAS-like, estrogen-regulated, growth inhibitor (RERG), mRNA","Q0VCJ7",412,{"v":4e-137,"d":"4.00E-137"},"Ras-related and estrogen-regulated growth inhibitor",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0030308|negative regulation of cell growth;GO:0008285|negative regulation of cell proliferation;GO:0009725|response to hormone;GO:0007165|signal transduction;","GO:0005829|cytosol;GO:0016020|membrane;GO:0005634|nucleus;","GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07855","RERG; Ras-related and estrogen-regulated growth inhibitor"]
["gene7213",1012,2603,2054,1747.62767008405,639,870,749,828.485688100435,2.10942409167144,1.07684917262975,{"v":3.77513476280141e-05,"d":"3.78E-05"},0.0012807178349285,"up","yes","PLBD1","protein_coding","chrNC_037332.1:95273631-95362983:+","gi|741927569|ref|XP_005207028.2|",2833,0,"PREDICTED: phospholipase B-like 1 isoform X1 [Bos taurus]","gi|982926708|ref|XM_005206971.3|",2432,0,"PREDICTED: Bos taurus phospholipase B domain containing 1 (PLBD1), transcript variant X1, mRNA","Q9GL30",952,0,"Phospholipase B-like 1",".",".",".",".","pfam04916","Phospholip_B","Phospholipase B. Phospholipase B (PLB) catalyses the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.","GO:0016042|lipid catabolic process;","GO:0005615|extracellular space;GO:0005764|lysosome;","GO:0016787|hydrolase activity;",".","."]
["gene7221",0,104,0,34.0826386374855,0,0,0,0,"Inf","Inf",{"v":7.33909457307404e-10,"d":"7.34E-10"},{"v":1.01646459837075e-07,"d":"1.02E-07"},"up","yes","GSG1","protein_coding","chrNC_037332.1:96766276-96785809:+","gi|982926768|ref|XP_015326740.1|",1865,0,"PREDICTED: germ cell-specific gene 1 protein isoform X1 [Bos taurus]","gi|982926767|ref|XM_015471254.1|",1412,0,"PREDICTED: Bos taurus germ cell associated 1 (GSG1), transcript variant X1, mRNA","Q3SZT1",586,0,"Germ cell-specific gene 1 protein",".",".",".",".","pfam07803","GSG-1","GSG1-like protein. This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumorigenesis of human testicular germ cell tumors. The region in question has four highly-conserved cysteine residues.",".","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0070063|RNA polymerase binding;",".","."]
["gene7413",0,34,2,11.7566443602403,0,1,0,0.366987568989444,32.0355384042407,5.00160133220086,0.00103711730779753,0.0185750118699129,"up","yes","LRRC23","protein_coding","chrNC_037332.1:103546870-103554402:-","gi|594084713|ref|XP_006065911.1|",1400,0,"PREDICTED: leucine-rich repeat-containing protein 23 [Bubalus bubalis]","gi|402744017|ref|NM_001038199.2|",1582,0,"Bos taurus leucine rich repeat containing 23 (LRRC23), mRNA",".",".",".",".","CAC3280_2",79,{"v":4e-15,"d":"4.00E-15"},"COG4886","pfam12799","LRR_4","Leucine Rich repeats (2 copies). Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.",".",".",".",".","."]
["gene7415",37206,104763,76796,67615.148351016,11685,20397,15103,17304.6991127974,3.90732874985456,1.9661826442679,{"v":4.05721671678543e-07,"d":"4.06E-07"},{"v":2.80281961614056e-05,"d":"2.80E-05"},"up","yes","TPI1","protein_coding","chrNC_037332.1:103580104-103583461:-","gi|555991526|ref|XP_005907547.1|",1378,0,"PREDICTED: triosephosphate isomerase isoform X1 [Bos mutus]","gi|402693364|ref|NM_001013589.3|",1256,0,"Bos taurus triosephosphate isomerase 1 (TPI1), mRNA","Q5E956",511,0,"Triosephosphate isomerase","YDR050c",273,{"v":5e-88,"d":"5.00E-88"},"COG0149","pfam00121","TIM","Triosephosphate isomerase.","GO:0006094|gluconeogenesis;GO:0046166|glyceraldehyde-3-phosphate biosynthetic process;GO:0019563|glycerol catabolic process;GO:0006096|glycolytic process;GO:0007275|multicellular organismal development;","GO:0005829|cytosol;","GO:0004807|triose-phosphate isomerase activity;GO:0031625|ubiquitin protein ligase binding;","K01803","TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1]"]
["gene7422",1600,1412,1173,1239.98821819995,550,425,581,571.267414613533,2.17059154168422,1.11808826753387,{"v":1.04632655852831e-05,"d":"1.05E-05"},0.000447189732282794,"up","yes","PTMS","protein_coding","chrNC_037332.1:103674101-103678695:-","gi|803249857|ref|XP_011984911.1|",168,{"v":3e-10,"d":"3.00E-10"},"PREDICTED: transcription initiation factor TFIID subunit 4 [Ovis aries musimon]","gi|157279906|ref|NM_001104999.1|",980,0,"Bos taurus parathymosin (PTMS), mRNA","P20962",53.5,{"v":1e-07,"d":"1.00E-07"},"Parathymosin",".",".",".",".","pfam03247","Prothymosin","Prothymosin/parathymosin family. Prothymosin alpha and parathymosin are two ubiquitous small acidic nuclear proteins that are thought to be involved in cell cycle progression, proliferation, and cell differentiation.","GO:0006260|DNA replication;GO:0002376|immune system process;","GO:0005634|nucleus;",".",".","."]
["gene7441",161,189,182,159.79511981735,63,63,71,72.2966816081628,2.2102690782326,1.14422201405164,0.00260448938453117,0.0372101585528587,"up","yes","VAMP1","protein_coding","chrNC_037332.1:103915379-103922326:+","gi|533127348|ref|XP_005378839.1|",460,{"v":3e-49,"d":"3.00E-49"},"PREDICTED: vesicle-associated membrane protein 1 [Chinchilla lanigera]","gi|136255756|ref|NM_001075630.2|",2584,0,"Bos taurus vesicle associated membrane protein 1 (VAMP1), mRNA","Q0V7N0",171,{"v":4e-48,"d":"4.00E-48"},"Vesicle-associated membrane protein 1","YAL030w",58.9,{"v":3e-09,"d":"3.00E-09"},"COG5143","pfam00957","Synaptobrevin","Synaptobrevin.","GO:0006887|exocytosis;GO:0006906|vesicle fusion;","GO:0030054|cell junction;GO:0016021|integral component of membrane;GO:0043005|neuron projection;GO:0031201|SNARE complex;GO:0030672|synaptic vesicle membrane;","GO:0005484|SNAP receptor activity;GO:0019905|syntaxin binding;","K08510","VAMP1; vesicle-associated membrane protein 1"]
["gene7460",341,167,130,183.527188557702,45,40,58,52.4354943481856,3.50005641863568,1.80737817755185,{"v":1.35842505925845e-06,"d":"1.36E-06"},{"v":7.94205437821782e-05,"d":"7.94E-05"},"up","yes","KCNA5","protein_coding","chrNC_037332.1:105143974-105146171:-","gi|296487078|tpg|DAA29191.1|",2395,0,"TPA: potassium voltage-gated channel, shaker-related subfamily, member 5 [Bos taurus]","gi|62751971|ref|NM_001015552.1|",2186,0,"Bos taurus potassium channel, voltage gated shaker related subfamily A, member 5 (KCNA5), mRNA","P79197",844,0,"Potassium voltage-gated channel subfamily A member 5","MA2034",77.4,{"v":1e-14,"d":"1.00E-14"},"COG1226","pfam02214","BTB_2","BTB/POZ domain. In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.","GO:0060081|membrane hyperpolarization;GO:0098914|membrane repolarization during atrial cardiac muscle cell action potential;GO:0043267|negative regulation of potassium ion transport;GO:0007219|Notch signaling pathway;GO:0071435|potassium ion export;GO:0071805|potassium ion transmembrane transport;GO:0051260|protein homooligomerization;GO:0060372|regulation of atrial cardiac muscle cell membrane repolarization;GO:0086091|regulation of heart rate by cardiac conduction;GO:0019229|regulation of vasoconstriction;","GO:0009986|cell surface;GO:0005887|integral component of plasma membrane;GO:0014704|intercalated disc;GO:0045121|membrane raft;GO:0034705|potassium channel complex;GO:0008076|voltage-gated potassium channel complex;","GO:0051393|alpha-actinin binding;GO:0005251|delayed rectifier potassium channel activity;GO:0015271|outward rectifier potassium channel activity;GO:0019870|potassium channel inhibitor activity;GO:0019901|protein kinase binding;GO:0097110|scaffold protein binding;GO:0086089|voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization;GO:0086087|voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization;GO:0086090|voltage-gated potassium channel activity involved in SA node cell action potential repolarization;",".","."]
["gene7466",0,117,1,38.6500901007793,7,1,3,4.06628286564336,9.50501757448793,3.24868929437547,0.00212441877079206,0.0321528285801989,"up","yes","AKAP3","protein_coding","chrNC_037332.1:105495961-105523869:+","gi|982927031|ref|XP_015326802.1|",4630,0,"PREDICTED: A-kinase anchor protein 3 isoform X1 [Bos taurus]","gi|402743570|ref|NM_001101039.2|",2894,0,"Bos taurus A-kinase anchoring protein 3 (AKAP3), mRNA","O77797",1784,0,"A-kinase anchor protein 3",".",".",".",".","pfam05716","AKAP_110","A-kinase anchor protein 110 kDa (AKAP 110). This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.","GO:0010738|regulation of protein kinase A signaling;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0035686|sperm fibrous sheath;GO:0097228|sperm principal piece;","GO:0051018|protein kinase A binding;","K16520","AKAP3; A-kinase anchor protein 3"]
["gene7495",194,30,60,78.8197363389089,33,18,29,29.4083369830552,2.68018339099977,1.4223317201733,0.00378545525023037,0.0488479528468217,"up","yes","NRIP2","protein_coding","chrNC_037332.1:106904505-106928407:+","gi|982927157|ref|XP_015326828.1|",1240,{"v":7e-160,"d":"7.00E-160"},"PREDICTED: nuclear receptor-interacting protein 2, partial [Bos taurus]","gi|742145816|ref|XM_010845209.1|",2282,0,"PREDICTED: Bison bison bison nuclear receptor-interacting protein 2-like (LOC104992348), mRNA","Q9BQI9",273,{"v":1e-82,"d":"1.00E-82"},"Nuclear receptor-interacting protein 2",".",".",".",".","pfam06346","Drf_FH1","Formin Homology Region 1. This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0004190|aspartic-type endopeptidase activity;","K13215","NRIP2; nuclear receptor-interacting protein 2"]
["gene7566",255,281,248,234.713758385095,76,99,108,103.723216136956,2.26288546698339,1.178163566312,0.000587493315539877,0.0119726941326202,"up","yes","GCAT","protein_coding","chrNC_037332.1:109622546-109629294:+","gi|115495187|ref|NP_001068602.1|",1645,0,"2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor [Bos taurus]","gi|742144412|ref|XM_010845080.1|",1070,0,"PREDICTED: Bison bison bison glycine C-acetyltransferase (GCAT), mRNA","Q0P5L8",638,0,"2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial","SMc01565",311,{"v":4e-113,"d":"4.00E-113"},"COG0156","pfam00155","Aminotran_1_2","Aminotransferase class I and II.","GO:0009058|biosynthetic process;GO:0019518|L-threonine catabolic process to glycine;","GO:0005739|mitochondrion;GO:0016607|nuclear speck;","GO:0008890|glycine C-acetyltransferase activity;GO:0030170|pyridoxal phosphate binding;","K00639","kbl, GCAT; glycine C-acetyltransferase [EC:2.3.1.29]"]
["gene7591",1404,1500,1264,1245.69328820857,540,516,538,585.403768286235,2.12792154012832,1.08944495734541,{"v":1.84193545925828e-05,"d":"1.84E-05"},0.000710165683622944,"up","yes","JOSD1","protein_coding","chrNC_037332.1:110317480-110329100:-","gi|62460488|ref|NP_001014898.1|",1025,{"v":1e-127,"d":"1.00E-127"},"josephin-1 [Bos taurus]","gi|982927266|ref|XM_005207319.2|",3461,0,"PREDICTED: Bos taurus Josephin domain containing 1 (JOSD1), transcript variant X2, mRNA","Q5EAE5",399,{"v":4e-129,"d":"4.00E-129"},"Josephin-1",".",".",".",".","pfam02099","Josephin","Josephin.","GO:0016579|protein deubiquitination;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0004843|ubiquitin-specific protease activity;","K15235","JOSD; josephin [EC:3.4.19.12]"]
["gene7595",174,117,155,131.295264885928,66,39,54,58.4737451192657,2.24537122802947,1.16695398597391,0.00346291319761372,0.0459210733388523,"up","yes","NPTXR","protein_coding","chrNC_037332.1:110424112-110464435:-","gi|965842709|ref|XP_011991921.2|",2113,0,"PREDICTED: neuronal pentraxin receptor isoform X2 [Ovis aries musimon]","gi|982927299|ref|XM_003586153.3|",5266,0,"PREDICTED: Bos taurus neuronal pentraxin receptor (NPTXR), partial mRNA","O95502",754,0,"Neuronal pentraxin receptor",".",".",".",".","pfam00354","Pentaxin","Pentaxin family. Pentaxins are also known as pentraxins.",".","GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;",".","."]
["gene7605",2236,543,963,1056.46239053955,463,449,491,515.069732462403,2.05110555708428,1.036401739874,0.000112014802695356,0.00317999436388181,"up","yes","PDGFB","protein_coding","chrNC_037332.1:110665513-110686525:-","gi|528951435|ref|XP_005207395.1|",828,{"v":2e-98,"d":"2.00E-98"},"PREDICTED: platelet-derived growth factor subunit B isoform X1 [Bos taurus]","gi|982927287|ref|XM_005207340.3|",2506,0,"PREDICTED: Bos taurus platelet derived growth factor subunit B (PDGFB), transcript variant X3, mRNA","Q95229",310,{"v":4e-95,"d":"4.00E-95"},"Platelet-derived growth factor subunit B",".",".",".",".","pfam00341","PDGF","PDGF/VEGF domain.","GO:0032147|activation of protein kinase activity;GO:0032148|activation of protein kinase B activity;GO:0060326|cell chemotaxis;GO:0071506|cellular response to mycophenolic acid;GO:0001892|embryonic placenta development;GO:0007507|heart development;GO:0072255|metanephric glomerular mesangial cell development;GO:0002548|monocyte chemotaxis;GO:0010512|negative regulation of phosphatidylinositol biosynthetic process;GO:0010544|negative regulation of platelet activation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0038001|paracrine signaling;GO:0018105|peptidyl-serine phosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0048008|platelet-derived growth factor receptor signaling pathway;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0090280|positive regulation of calcium ion import;GO:0051781|positive regulation of cell division;GO:0008284|positive regulation of cell proliferation;GO:0050921|positive regulation of chemotaxis;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:2000573|positive regulation of DNA biosynthetic process;GO:0001938|positive regulation of endothelial cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0048146|positive regulation of fibroblast proliferation;GO:0003104|positive regulation of glomerular filtration;GO:0072126|positive regulation of glomerular mesangial cell proliferation;GO:1900127|positive regulation of hyaluronan biosynthetic process;GO:0043406|positive regulation of MAP kinase activity;GO:0043410|positive regulation of MAPK cascade;GO:2000591|positive regulation of metanephric mesenchymal cell migration;GO:0035793|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway;GO:0045840|positive regulation of mitotic nuclear division;GO:0043552|positive regulation of phosphatidylinositol 3-kinase activity;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0031954|positive regulation of protein autophosphorylation;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:2000379|positive regulation of reactive oxygen species metabolic process;GO:0014911|positive regulation of smooth muscle cell migration;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0045893|positive regulation of transcription, DNA-templated;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:0006468|protein phosphorylation;GO:0072593|reactive oxygen species metabolic process;GO:0009611|response to wounding;","GO:0016323|basolateral plasma membrane;GO:0009986|cell surface;GO:0005737|cytoplasm;GO:0005576|extracellular region;","GO:0008083|growth factor activity;GO:0005161|platelet-derived growth factor receptor binding;GO:0042803|protein homodimerization activity;GO:0016176|superoxide-generating NADPH oxidase activator activity;","K17386","PDGFB; platelet-derived growth factor subunit B"]
["gene7631",794,1383,1329,1068.33305145584,382,436,448,464.501844557076,2.29995437902845,1.20160524473392,{"v":4.43324146422497e-06,"d":"4.43E-06"},0.000212222839288259,"up","yes","MKL1","protein_coding","chrNC_037332.1:111739964-111951334:-","gi|803264280|ref|XP_011991856.1|",4038,0,"PREDICTED: MKL/myocardin-like protein 1 isoform X2 [Ovis aries musimon]","gi|982982676|ref|XM_015463609.1|",4563,0,"PREDICTED: Bos taurus megakaryoblastic leukemia (translocation) 1 (MKL1), transcript variant X2, mRNA","Q969V6",747,0,"MKL/myocardin-like protein 1",".",".",".",".","pfam02037","SAP","SAP domain. The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.","GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0010735|positive regulation of transcription via serum response element binding;GO:0051145|smooth muscle cell differentiation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003779|actin binding;GO:0003785|actin monomer binding;GO:0043522|leucine zipper domain binding;GO:0001105|RNA polymerase II transcription coactivator activity;GO:0003713|transcription coactivator activity;",".","."]
["gene7720",8,91,0,31.9072947024895,2,4,5,4.02035089859375,7.93644522761685,2.98849296192155,0.000177370169694152,0.00460887824366471,"up","yes","EFCAB6","protein_coding","chrNC_037332.1:114257682-114511664:-","gi|528951757|ref|XP_003586209.2|",7717,0,"PREDICTED: EF-hand calcium-binding domain-containing protein 6 isoform X1 [Bos taurus]","gi|982982744|ref|XM_015463631.1|",5276,0,"PREDICTED: Bos taurus EF-hand calcium binding domain 6 (EFCAB6), transcript variant X2, mRNA","Q5THR3",2249,0,"EF-hand calcium-binding domain-containing protein 6",".",".",".",".","pfam08976","DUF1880","Domain of unknown function (DUF1880). This domain is found predominantly in DJ binding protein. It has no known function.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;","GO:0005509|calcium ion binding;",".","."]
["gene774",220,156,159,157.293409803883,59,78,54,70.1698836785599,2.24160853001304,1.16453435079219,0.00208925928889695,0.0317526636831489,"up","yes","ECT2","protein_coding","chrNC_037328.1:94709110-94769494:-","gi|741914433|ref|XP_010799664.1|",4707,0,"PREDICTED: protein ECT2 isoform X1 [Bos taurus]","gi|982911193|ref|XM_010801365.2|",4040,0,"PREDICTED: Bos taurus epithelial cell transforming 2 (ECT2), transcript variant X4, mRNA","Q9H8V3",1712,0,"Protein ECT2","SPCC645.07",64.3,{"v":2e-09,"d":"2.00E-09"},"COG5422","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0090630|activation of GTPase activity;GO:0032147|activation of protein kinase activity;GO:0070830|bicellular tight junction assembly;GO:0000902|cell morphogenesis;GO:0071277|cellular response to calcium ion;GO:0070301|cellular response to hydrogen peroxide;GO:0071479|cellular response to ionizing radiation;GO:0007186|G-protein coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0000281|mitotic cytokinesis;GO:0043065|positive regulation of apoptotic process;GO:0032467|positive regulation of cytokinesis;GO:0043547|positive regulation of GTPase activity;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0045666|positive regulation of neuron differentiation;GO:0042307|positive regulation of protein import into nucleus;GO:0051260|protein homooligomerization;GO:0015031|protein transport;GO:0051988|regulation of attachment of spindle microtubules to kinetochore;GO:0045859|regulation of protein kinase activity;GO:0035023|regulation of Rho protein signal transduction;GO:0051056|regulation of small GTPase mediated signal transduction;","GO:0005923|bicellular tight junction;GO:0005911|cell-cell junction;GO:0097149|centralspindlin complex;GO:0032154|cleavage furrow;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030496|midbody;GO:0072686|mitotic spindle;GO:0005634|nucleus;","GO:0005096|GTPase activator activity;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0042803|protein homodimerization activity;GO:0005089|Rho guanyl-nucleotide exchange factor activity;",".","."]
["gene7743",744,164,354,356.37044589329,175,130,163,171.956380568861,2.07244677234049,1.05133504875768,0.000853379010024725,0.0160288061455006,"up","yes","FAM118A","protein_coding","chrNC_037332.1:115706993-115732871:+","gi|742108699|ref|XP_010835906.1|",1907,0,"PREDICTED: protein FAM118A isoform X1 [Bison bison bison]","gi|931716600|ref|NM_001038035.3|",2301,0,"Bos taurus family with sequence similarity 118 member A (FAM118A), transcript variant 1, mRNA","Q91YN1",696,0,"Protein FAM118A",".",".",".",".","pfam13289","SIR2_2","SIR2-like domain. This family of proteins are related to the sirtuins.",".","GO:0016021|integral component of membrane;","GO:0042802|identical protein binding;",".","."]
["gene7796",320,71,51,122.330594325269,20,44,37,36.9788117120032,3.30812669909457,1.72601448984626,0.000371535207955206,0.00834010308274587,"up","yes","LOC101903647","protein_coding","chrNC_037332.1:119328389-119339909:-","gi|982927638|ref|XP_015326954.1|",481,{"v":2e-48,"d":"2.00E-48"},"PREDICTED: uncharacterized protein LOC101903647 [Bos taurus]","gi|982982857|ref|XM_010808522.2|",2298,0,"PREDICTED: Bos taurus uncharacterized LOC101903647 (LOC101903647), mRNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["gene7799",4,23,13,12.5725808060018,1,1,0,0.740755659174328,16.9726422610333,4.08513927262323,0.00163245579203091,0.0265236880423883,"up","yes","TTLL8","protein_coding","chrNC_037332.1:119392261-119451202:-","gi|594085836|ref|XP_006066437.1|",3946,0,"PREDICTED: protein monoglycylase TTLL8 [Bubalus bubalis]","gi|594085835|ref|XM_006066375.1|",2317,0,"PREDICTED: Bubalus bubalis tubulin tyrosine ligase-like family, member 8 (TTLL8), mRNA","A6PVC2",1006,0,"Protein monoglycylase TTLL8",".",".",".",".","pfam03133","TTL","Tubulin-tyrosine ligase family. Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyses the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumor aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.","GO:0018094|protein polyglycylation;","GO:0005930|axoneme;GO:0005929|cilium;GO:0005829|cytosol;GO:0005874|microtubule;GO:0015630|microtubule cytoskeleton;","GO:0005524|ATP binding;GO:0070735|protein-glycine ligase activity;GO:0070736|protein-glycine ligase activity, initiating;",".","."]
["gene7836",2467,794,1005,1211.82260434111,442,406,497,493.605974432694,2.45504039073649,1.29574676019613,{"v":7.76881437793268e-07,"d":"7.77E-07"},{"v":4.86079041703503e-05,"d":"4.86E-05"},"up","yes","SHANK3","protein_coding","chrNC_037332.1:119959307-120008278:+","gi|982982854|ref|XP_015319156.1|",6385,0,"PREDICTED: SH3 and multiple ankyrin repeat domains protein 3 isoform X2 [Bos taurus]","gi|982982853|ref|XM_015463670.1|",6826,0,"PREDICTED: Bos taurus SH3 and multiple ankyrin repeat domains 3 (SHANK3), transcript variant X2, mRNA","Q9BYB0",2355,0,"SH3 and multiple ankyrin repeat domains protein 3",".",".",".",".","pfam00536","SAM_1","SAM domain (Sterile alpha motif). It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.","GO:0030534|adult behavior;GO:0097113|AMPA glutamate receptor clustering;GO:0007411|axon guidance;GO:0048854|brain morphogenesis;GO:0060997|dendritic spine morphogenesis;GO:0097117|guanylate kinase-associated protein clustering;GO:0007612|learning;GO:0000165|MAPK cascade;GO:0007613|memory;GO:0032232|negative regulation of actin filament bundle assembly;GO:0045794|negative regulation of cell volume;GO:0097114|NMDA glutamate receptor clustering;GO:2000969|positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;GO:0060999|positive regulation of dendritic spine development;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:1900451|positive regulation of glutamate receptor signaling pathway;GO:0048170|positive regulation of long-term neuronal synaptic plasticity;GO:1900273|positive regulation of long-term synaptic potentiation;GO:0051835|positive regulation of synapse structural plasticity;GO:0051968|positive regulation of synaptic transmission, glutamatergic;GO:0097107|postsynaptic density assembly;GO:0061001|regulation of dendritic spine morphogenesis;GO:1900452|regulation of long term synaptic depression;GO:1900271|regulation of long-term synaptic potentiation;GO:0035176|social behavior;GO:0021773|striatal medium spiny neuron differentiation;GO:0007416|synapse assembly;GO:0042297|vocal learning;GO:0071625|vocalization behavior;","GO:0030054|cell junction;GO:0060170|ciliary membrane;GO:0005829|cytosol;GO:0043197|dendritic spine;GO:0043005|neuron projection;GO:0044309|neuron spine;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;","GO:0003779|actin binding;GO:0030160|GKAP/Homer scaffold activity;GO:0035255|ionotropic glutamate receptor binding;GO:0008022|protein C-terminus binding;GO:0043621|protein self-association;GO:0097110|scaffold protein binding;GO:0017124|SH3 domain binding;GO:0008270|zinc ion binding;","K15009","SHANK; SH3 and multiple ankyrin repeat domains protein"]
["gene7858",106,91,97,87.2391703724241,14,9,13,13.2282889333855,6.59489453335497,2.72134958784339,{"v":1.14410908746623e-07,"d":"1.14E-07"},{"v":9.43427062846795e-06,"d":"9.43E-06"},"up","yes","NPY1R","protein_coding","chrNC_037333.1:2433610-2442876:+","gi|114052535|ref|NP_001039363.1|",1853,0,"neuropeptide Y receptor type 1 [Bos taurus]","gi|982927688|ref|XM_005207560.3|",3193,0,"PREDICTED: Bos taurus neuropeptide Y receptor Y1 (NPY1R), transcript variant X1, mRNA","Q1RMU8",718,0,"Neuropeptide Y receptor type 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0008015|blood circulation;GO:0007268|synaptic transmission;GO:0007631|feeding behavior;GO:0006006|glucose metabolic process;GO:0007626|locomotory behavior;GO:0007218|neuropeptide signaling pathway;GO:0003151|outflow tract morphogenesis;GO:0008217|regulation of blood pressure;GO:0040014|regulation of multicellular organism growth;GO:0019233|sensory perception of pain;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0001602|pancreatic polypeptide receptor activity;GO:0001601|peptide YY receptor activity;","K04204","NPY1R; neuropeptide Y receptor type 1"]
["gene7887",7420,4798,4698,4949.07127684878,1865,1916,1901,2086.4351313282,2.37202259611985,1.2461177532038,{"v":6.20385341704268e-07,"d":"6.20E-07"},{"v":4.05780663542821e-05,"d":"4.06E-05"},"up","yes","USP53","protein_coding","chrNC_037333.1:6014303-6072501:-","gi|742077596|ref|XP_010833277.1|",5321,0,"PREDICTED: inactive ubiquitin carboxyl-terminal hydrolase 53 [Bison bison bison]","gi|942060453|ref|XM_005898066.2|",3683,0,"PREDICTED: Bos mutus ubiquitin specific peptidase 53 (USP53), mRNA","Q70EK8",1623,0,"Inactive ubiquitin carboxyl-terminal hydrolase 53",".",".",".",".","pfam00443","UCH","Ubiquitin carboxyl-terminal hydrolase.","GO:0001508|action potential;GO:0051402|neuron apoptotic process;GO:0016579|protein deubiquitination;GO:0010996|response to auditory stimulus;GO:0007605|sensory perception of sound;","GO:0005923|bicellular tight junction;",".",".","."]
["gene8032",44,293,253,185.190475731174,17,18,21,20.5402644324711,9.01597330161024,3.17248324336156,{"v":3.88191972825415e-14,"d":"3.88E-14"},{"v":1.17824523156191e-11,"d":"1.18E-11"},"up","yes","BANK1","protein_coding","chrNC_037333.1:22695177-23016149:-","gi|741929351|ref|XP_010804255.1|",3632,0,"PREDICTED: B-cell scaffold protein with ankyrin repeats isoform X1 [Bos taurus]","gi|982983057|ref|XM_015463720.1|",3317,0,"PREDICTED: Bos taurus B-cell scaffold protein with ankyrin repeats 1 (BANK1), transcript variant X1, mRNA","Q8NDB2",1001,0,"B-cell scaffold protein with ankyrin repeats",".",".",".",".","pfam14545","DBB","Dof, BCAP, and BANK (DBB) motif,. The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerization. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling.","GO:0042113|B cell activation;GO:0050869|negative regulation of B cell activation;GO:1900165|negative regulation of interleukin-6 secretion;GO:0051898|negative regulation of protein kinase B signaling;GO:0045947|negative regulation of translational initiation;GO:0043410|positive regulation of MAPK cascade;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;",".","GO:1990782|protein tyrosine kinase binding;GO:0005102|receptor binding;",".","."]
["gene8034",5589,8279,5774,5943.11824928214,1633,2769,2015,2353.91224003697,2.52478327279898,1.33615955234855,0.000132492341650502,0.00367717801520474,"up","yes","PPP3CA","protein_coding","chrNC_037333.1:23444690-23770287:+","gi|926693529|ref|XP_013819948.1|",2909,0,"PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [Capra hircus]","gi|982927929|ref|XM_005207693.3|",4708,0,"PREDICTED: Bos taurus protein phosphatase 3, catalytic subunit, alpha isozyme (PPP3CA), transcript variant X1, mRNA","P48452",1033,0,"Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform","SPBC1346.01c",656,0,"COG0639","pfam00149","Metallophos","Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.","GO:0033173|calcineurin-NFAT signaling cascade;GO:0006816|calcium ion transport;GO:0014898|cardiac muscle hypertrophy in response to stress;GO:0035690|cellular response to drug;GO:0016311|dephosphorylation;GO:0060079|excitatory postsynaptic potential;GO:0000082|G1/S transition of mitotic cell cycle;GO:0050804|modulation of synaptic transmission;GO:0033555|multicellular organismal response to stress;GO:0035562|negative regulation of chromatin binding;GO:0050774|negative regulation of dendrite morphogenesis;GO:1903799|negative regulation of production of miRNAs involved in gene silencing by miRNA;GO:0070886|positive regulation of calcineurin-NFAT signaling cascade;GO:1903244|positive regulation of cardiac muscle hypertrophy in response to stress;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0045807|positive regulation of endocytosis;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006470|protein dephosphorylation;GO:0006606|protein import into nucleus;GO:0051592|response to calcium ion;GO:0048741|skeletal muscle fiber development;GO:0014883|transition between fast and slow fiber;","GO:0005955|calcineurin complex;GO:0009898|cytoplasmic side of plasma membrane;GO:0005829|cytosol;GO:0043197|dendritic spine;GO:0005739|mitochondrion;GO:0005654|nucleoplasm;GO:0042383|sarcolemma;GO:0030018|Z disc;","GO:0005516|calmodulin binding;GO:0033192|calmodulin-dependent protein phosphatase activity;GO:0016018|cyclosporin A binding;GO:0019899|enzyme binding;GO:0046872|metal ion binding;GO:0046983|protein dimerization activity;","K04348","PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]"]
["gene8035",1493,358,436,640.338454005556,185,220,224,230.742288875407,2.77512395810252,1.47255221461434,{"v":3.42945693359398e-07,"d":"3.43E-07"},{"v":2.43348107028367e-05,"d":"2.43E-05"},"up","yes","EMCN","protein_coding","chrNC_037333.1:24210539-24332555:+","gi|528952445|ref|XP_005207759.1|",1029,{"v":4e-133,"d":"4.00E-133"},"PREDICTED: endomucin isoform X1 [Bos taurus]","gi|982927934|ref|XM_005207702.3|",1555,0,"PREDICTED: Bos taurus endomucin (EMCN), transcript variant X1, mRNA","Q9ULC0",180,{"v":3e-50,"d":"3.00E-50"},"Endomucin",".",".",".",".","pfam07010","Endomucin","Endomucin. This family consists of several mammalian endomucin proteins. Endomucin is an early endothelial-specific antigen that is also expressed on putative hematopoietic progenitor cells.",".","GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".","K16664","EMCN; endomucin"]
["gene8102",842,127,100,291.777074036137,80,87,121,105.507085219715,2.76547374452171,1.46752664513533,{"v":2.01088667721502e-05,"d":"2.01E-05"},0.00076598942306571,"up","yes","GPRIN3","protein_coding","chrNC_037333.1:35497277-35574468:+","gi|296486666|tpg|DAA28779.1|",3964,0,"TPA: KIAA2027 protein-like [Bos taurus]","gi|982983099|ref|XM_005198604.3|",11352,0,"PREDICTED: Bos taurus GPRIN family member 3 (GPRIN3), mRNA",".",".",".",".",".",".",".",".","pfam15235","GRIN_C","G protein-regulated inducer of neurite outgrowth C-terminus. This represents the C-terminus of the G protein-regulated inducer of neurite outgrowth proteins.",".",".",".",".","."]
["gene8145",23212,2089,2598,7532.09080941856,616,977,742,856.629881688881,8.79270145768057,3.13630648514396,{"v":1.2978231633508e-21,"d":"1.30E-21"},{"v":1.08906449039887e-18,"d":"1.09E-18"},"up","yes","PPARGC1A","protein_coding","chrNC_037333.1:43380463-43903480:-","gi|741929523|ref|XP_010804313.1|",3430,0,"PREDICTED: peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4 [Bos taurus]","gi|982928050|ref|XM_015471552.1|",6513,0,"PREDICTED: Bos taurus peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A), transcript variant X7, mRNA","Q865B7",1293,0,"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:0050873|brown fat cell differentiation;GO:0045333|cellular respiration;GO:0034599|cellular response to oxidative stress;GO:0032922|circadian regulation of gene expression;GO:0097009|energy homeostasis;GO:0007005|mitochondrion organization;GO:0043524|negative regulation of neuron apoptotic process;GO:1901215|negative regulation of neuron death;GO:2001171|positive regulation of ATP biosynthetic process;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0046321|positive regulation of fatty acid oxidation;GO:0010822|positive regulation of mitochondrion organization;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0042752|regulation of circadian rhythm;GO:0006355|regulation of transcription, DNA-templated;GO:0022904|respiratory electron transport chain;GO:0014850|response to muscle activity;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;GO:0016605|PML body;","GO:0031490|chromatin DNA binding;GO:0003677|DNA binding;GO:0030374|ligand-dependent nuclear receptor transcription coactivator activity;GO:0003723|RNA binding;GO:0001104|RNA polymerase II transcription cofactor activity;GO:0043565|sequence-specific DNA binding;GO:0005102|receptor binding;GO:0003713|transcription coactivator activity;GO:0008134|transcription factor binding;","K07202","PPARGC1A, PGC1A; alpha peroxisome proliferator-activated receptor gamma coactivator 1-alpha"]
["gene8207",270,63,87,117.734069859697,15,24,25,23.438545219851,5.02309630377501,2.32857693490358,{"v":2.9508758430278e-07,"d":"2.95E-07"},{"v":2.12069115056489e-05,"d":"2.12E-05"},"up","yes","LOC783708","pseudogene","chrNC_037333.1:57227718-57229584:+","gi|694988245|ref|XP_009438577.1|",887,{"v":3e-110,"d":"3.00E-110"},"PREDICTED: heterogeneous nuclear ribonucleoprotein A1-like [Pan troglodytes]","gi|803290104|ref|XM_012149330.1|",1037,0,"PREDICTED: Ovis aries musimon heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), transcript variant X7, mRNA","A5A6H4",339,{"v":9e-110,"d":"9.00E-110"},"Heterogeneous nuclear ribonucleoprotein A1",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.","GO:1903936|cellular response to sodium arsenite;GO:0006397|mRNA processing;GO:0051028|mRNA transport;GO:0008380|RNA splicing;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0005681|spliceosomal complex;","GO:0003723|RNA binding;","K12741","HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3"]
["gene8340",6001,1112,2048,2557.40720916123,1201,1071,1113,1243.7019875482,2.05628618010238,1.04004106311296,{"v":6.84548703522321e-05,"d":"6.85E-05"},0.00211601939980448,"up","yes","KDR","protein_coding","chrNC_037333.1:70567551-70612680:-","gi|158508551|ref|NP_001103470.1|",7154,0,"vascular endothelial growth factor receptor 2 precursor [Bos taurus]","gi|158508550|ref|NM_001110000.1|",5998,0,"Bos taurus kinase insert domain receptor (KDR), mRNA","P35968",2545,0,"Vascular endothelial growth factor receptor 2",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0001525|angiogenesis;GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0035924|cellular response to vascular endothelial growth factor stimulus;GO:0035162|embryonic hemopoiesis;GO:0003158|endothelium development;GO:0070371|ERK1 and ERK2 cascade;GO:0030198|extracellular matrix organization;GO:0043066|negative regulation of apoptotic process;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:0010629|negative regulation of gene expression;GO:0038083|peptidyl-tyrosine autophosphorylation;GO:0018108|peptidyl-tyrosine phosphorylation;GO:0045766|positive regulation of angiogenesis;GO:0043536|positive regulation of blood vessel endothelial cell migration;GO:0030335|positive regulation of cell migration;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0008284|positive regulation of cell proliferation;GO:0038033|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway;GO:0010595|positive regulation of endothelial cell migration;GO:0001938|positive regulation of endothelial cell proliferation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0051894|positive regulation of focal adhesion assembly;GO:0016239|positive regulation of macroautophagy;GO:0043410|positive regulation of MAPK cascade;GO:0051901|positive regulation of mitochondrial depolarization;GO:0090141|positive regulation of mitochondrial fission;GO:0051770|positive regulation of nitric-oxide synthase biosynthetic process;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0050927|positive regulation of positive chemotaxis;GO:0001934|positive regulation of protein phosphorylation;GO:2001214|positive regulation of vasculogenesis;GO:0046777|protein autophosphorylation;GO:0043491|protein kinase B signaling;GO:0008360|regulation of cell shape;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0048010|vascular endothelial growth factor receptor signaling pathway;GO:0001570|vasculogenesis;GO:0016032|viral process;","GO:0030054|cell junction;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0005768|endosome;GO:0005576|extracellular region;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0045121|membrane raft;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0097443|sorting endosome;","GO:0005524|ATP binding;GO:0019838|growth factor binding;GO:0051879|Hsp90 protein binding;GO:0042802|identical protein binding;GO:0005178|integrin binding;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0038085|vascular endothelial growth factor binding;GO:0005021|vascular endothelial growth factor-activated receptor activity;","K05098","KDR, VEGFR2; kinase insert domain protein receptor [EC:2.7.10.1]"]
["gene8356",142,154,134,128.631321132043,46,56,40,52.1835515500432,2.46497827976862,1.30157493430779,0.00141743788504137,0.0237887766459501,"up","yes","KIAA1211","protein_coding","chrNC_037333.1:71702642-71716207:+","gi|296486550|tpg|DAA28663.1|",971,{"v":6e-125,"d":"6.00E-125"},"TPA: hypothetical protein LOC511259 [Bos taurus]","gi|156120530|ref|NM_001101941.1|",1236,0,"Bos taurus uncharacterized LOC511259 (MGC148692), mRNA",".",".",".",".",".",".",".",".","pfam15262","DUF4592","Domain of unknown function (DUF4592). This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.",".",".",".",".","."]
["gene8377",9643,2354,3211,4270.80485517952,1548,1249,1727,1660.36065563276,2.57221516342901,1.36301132782475,{"v":1.62096682113146e-07,"d":"1.62E-07"},{"v":1.28110261422996e-05,"d":"1.28E-05"},"up","yes","IGFBP7","protein_coding","chrNC_037333.1:72405517-72485427:-","gi|594069036|ref|XP_006058434.1|",867,{"v":1e-111,"d":"1.00E-111"},"PREDICTED: insulin-like growth factor-binding protein 7 [Bubalus bubalis]","gi|402745809|ref|NM_001102300.2|",1119,0,"Bos taurus insulin like growth factor binding protein 7 (IGFBP7), mRNA","Q16270",320,{"v":7e-106,"d":"7.00E-106"},"Insulin-like growth factor-binding protein 7",".",".",".",".","pfam07648","Kazal_2","Kazal-type serine protease inhibitor domain. Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.","GO:0007155|cell adhesion;GO:0044267|cellular protein metabolic process;GO:0032870|cellular response to hormone stimulus;GO:0007566|embryo implantation;GO:0008285|negative regulation of cell proliferation;GO:0043687|post-translational protein modification;GO:0001558|regulation of cell growth;GO:0050810|regulation of steroid biosynthetic process;GO:0051414|response to cortisol;GO:0009408|response to heat;GO:0032526|response to retinoic acid;","GO:0005788|endoplasmic reticulum lumen;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005520|insulin-like growth factor binding;",".","."]
["gene8463",0,36,1,12.1049580850454,0,0,0,0,"Inf","Inf",0.000168603366853945,0.00446235868247672,"up","yes","CABS1","protein_coding","chrNC_037333.1:85734578-85736673:+","gi|942057871|ref|XP_005897105.2|",1911,0,"PREDICTED: calcium-binding and spermatid-specific protein 1 [Bos mutus]","gi|94966870|ref|NM_001040539.1|",1461,0,"Bos taurus calcium-binding protein, spermatid-specific 1 (CABS1), mRNA","Q2TBJ9",734,0,"Calcium-binding and spermatid-specific protein 1",".",".",".",".","pfam15367","CABS1","Calcium-binding and spermatid-specific protein 1. CABS1 is a family of proteins found in eukaryotes. It is also known as NYD-SP26. It binds calcium and is specifically expressed in the elongate spermatids and then localized into the principal piece of flagella of matured spermatozoa.","GO:0007283|spermatogenesis;","GO:0005743|mitochondrial inner membrane;GO:0031514|motile cilium;","GO:0005509|calcium ion binding;",".","."]
["gene8484",1821,2508,3601,2402.45585635165,995,698,818,923.332395643343,2.6019403929586,1.37958791218329,{"v":2.63753687336629e-07,"d":"2.64E-07"},{"v":1.91968276872484e-05,"d":"1.92E-05"},"up","yes","SLC4A4","protein_coding","chrNC_037333.1:86449494-86813499:+","gi|671001109|ref|XP_008691417.1|",5295,0,"PREDICTED: electrogenic sodium bicarbonate cotransporter 1 isoform X1 [Ursus maritimus]","gi|742114700|ref|XM_010839087.1|",7854,0,"PREDICTED: Bison bison bison solute carrier family 4 (sodium bicarbonate cotransporter), member 4 (SLC4A4), transcript variant X2, mRNA","Q9GL77",2036,0,"Electrogenic sodium bicarbonate cotransporter 1",".",".",".",".","pfam00955","HCO3_cotransp","HCO3- transporter family. This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.","GO:0051453|regulation of intracellular pH;GO:0006814|sodium ion transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0005452|inorganic anion exchanger activity;GO:0008510|sodium:bicarbonate symporter activity;","K13575","SLC4A4, NBC1; solute carrier family 4 (sodium bicarbonate cotransporter), member 4"]
["gene8512",46,49,146,72.8865936823716,19,24,16,21.6848615845113,3.36117403370616,1.74896524394451,0.000730453366730193,0.0142450888627335,"up","yes","GRO1","protein_coding","chrNC_037333.1:89072989-89075128:+","gi|635043000|ref|XP_007997068.1|",391,{"v":2e-42,"d":"2.00E-42"},"PREDICTED: growth-regulated protein homolog gamma-like [Chlorocebus sabaeus]","gi|742111025|ref|XM_010838177.1|",1034,0,"PREDICTED: Bison bison bison growth-regulated protein homolog gamma (LOC104987311), mRNA","O46677",150,{"v":9e-43,"d":"9.00E-43"},"Growth-regulated protein homolog beta",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0070098|chemokine-mediated signaling pathway;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0090023|positive regulation of neutrophil chemotaxis;GO:0042127|regulation of cell proliferation;GO:0032496|response to lipopolysaccharide;","GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0045236|CXCR chemokine receptor binding;GO:0008083|growth factor activity;","K05505","CXCL1_2_3, GRO; C-X-C motif chemokine 1/2/3"]
["gene8521",249,96,99,126.761124903252,51,52,37,51.5015230596501,2.46130827541614,1.29942536464732,0.00125780320012678,0.021709850636913,"up","yes","PARM1","protein_coding","chrNC_037333.1:89847747-89973570:+","gi|115494988|ref|NP_001069239.1|",1123,{"v":7e-149,"d":"7.00E-149"},"prostate androgen-regulated mucin-like protein 1 precursor [Bos taurus]","gi|402692915|ref|NM_001075771.2|",1351,0,"Bos taurus prostate androgen-regulated mucin-like protein 1 (PARM1), mRNA","Q6UWI2",280,{"v":8e-89,"d":"8.00E-89"},"Prostate androgen-regulated mucin-like protein 1",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.","GO:0051973|positive regulation of telomerase activity;","GO:0005829|cytosol;GO:0005769|early endosome;GO:0010008|endosome membrane;GO:0005794|Golgi apparatus;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005770|late endosome;GO:0005634|nucleus;GO:0005886|plasma membrane;",".",".","."]
["gene8528",7687,21968,15929,14094.8533001138,2509,3247,2584,3062.14671854578,4.60293205898621,2.20255314799585,{"v":3.36146595219437e-15,"d":"3.36E-15"},{"v":1.19882481352572e-12,"d":"1.20E-12"},"up","yes","G3BP2","protein_coding","chrNC_037333.1:90467805-90560504:-","gi|440893995|gb|ELR46572.1|",1579,0,"Ras GTPase-activating protein-binding protein 2, partial [Bos mutus]","gi|742110938|ref|XM_010838154.1|",4453,0,"PREDICTED: Bison bison bison GTPase activating protein (SH3 domain) binding protein 2 (G3BP2), transcript variant X2, mRNA","Q5R9L3",591,0,"Ras GTPase-activating protein-binding protein 2",".",".",".",".","pfam02136","NTF2","Nuclear transport factor 2 (NTF2) domain. This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins.","GO:0051028|mRNA transport;GO:0034063|stress granule assembly;","GO:0005829|cytosol;","GO:0003723|RNA binding;",".","."]
["gene8641",10036,7922,8749,7898.80143200012,3035,3448,3395,3625.26224788548,2.17882208014255,1.12354839260986,{"v":1.76879692928292e-05,"d":"1.77E-05"},0.000687541487593612,"up","yes","AFF1","protein_coding","chrNC_037333.1:101852647-102047958:+","gi|741930575|ref|XP_010804602.1|",2921,0,"PREDICTED: AF4/FMR2 family member 1 isoform X2 [Bos taurus]","gi|982928797|ref|XM_005208211.3|",6842,0,"PREDICTED: Bos taurus AF4/FMR2 family member 1 (AFF1), transcript variant X1, mRNA","P51825",808,0,"AF4/FMR2 family member 1",".",".",".",".","pfam05110","AF-4","AF-4 proto-oncoprotein. This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X E mental retardation syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental retardation. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila.",".","GO:0008023|transcription elongation factor complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;","K15184","AFF1; AF4/FMR2 family member 1"]
["gene8651",10776,2176,4913,5030.47825601716,2132,1645,2006,2124.67973349901,2.36764072095362,1.24345017496024,{"v":2.18580787351111e-06,"d":"2.19E-06"},0.000118565481077605,"up","yes","SPARCL1","protein_coding","chrNC_037333.1:102370630-102423199:-","gi|77735557|ref|NP_001029474.1|",3148,0,"SPARC-like protein 1 precursor [Bos taurus]","gi|402745995|ref|NM_001034302.2|",2609,0,"Bos taurus SPARC like 1 (SPARCL1), mRNA","Q14515",827,0,"SPARC-like protein 1",".",".",".",".","pfam10591","SPARC_Ca_bdg","Secreted protein acidic and rich in cysteine Ca binding region. The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2.","GO:0048856|anatomical structure development;GO:0044267|cellular protein metabolic process;GO:0043687|post-translational protein modification;GO:0007165|signal transduction;","GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005509|calcium ion binding;GO:0005518|collagen binding;GO:0050840|extracellular matrix binding;",".","."]
["gene8676",185,70,75,94.1896588797682,16,10,21,17.2305957903707,5.46641915495493,2.45059608730168,{"v":4.71329810299713e-07,"d":"4.71E-07"},{"v":3.18661393783439e-05,"d":"3.19E-05"},"up","yes","NSG1","protein_coding","chrNC_037333.1:104689352-104738616:-","gi|426343698|ref|XP_004038428.1|",832,{"v":5e-102,"d":"5.00E-102"},"PREDICTED: neuron-specific protein family member 1-like isoform 3 [Gorilla gorilla gorilla]","gi|118151021|ref|NM_001077957.1|",2223,0,"Bos taurus neuron specific gene family member 1 (NSG1), mRNA","Q5RF46",311,{"v":4e-99,"d":"4.00E-99"},"Neuronal vesicle trafficking-associated protein 1",".",".",".",".","pfam06387","Calcyon","D1 dopamine receptor-interacting protein (calcyon). This family consists of several D1 dopamine receptor-interacting (calcyon) proteins. D1/D5 dopamine receptors in the basal ganglia, hippocampus, and cerebral cortex modulate motor, reward, and cognitive behaviour. D1-like dopamine receptors likely modulate neocortical and hippocampal neuronal excitability and synaptic function via Ca(2+) as well as cAMP-dependent signaling. Defective calcyon proteins have been implicated in both attention-deficit/hyperactivity disorder (ADHD) and schizophrenia.","GO:0042982|amyloid precursor protein metabolic process;GO:0006915|apoptotic process;GO:0048268|clathrin coat assembly;GO:0007212|dopamine receptor signaling pathway;GO:0001881|receptor recycling;GO:1900271|regulation of long-term synaptic potentiation;GO:0098814|spontaneous synaptic transmission;","GO:0030659|cytoplasmic vesicle membrane;GO:0030425|dendrite;GO:0031901|early endosome membrane;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0005768|endosome;GO:0032580|Golgi cisterna membrane;GO:0016021|integral component of membrane;GO:0005770|late endosome;GO:0016328|lateral plasma membrane;GO:0043202|lysosomal lumen;GO:0032585|multivesicular body membrane;GO:0045211|postsynaptic membrane;GO:0055038|recycling endosome membrane;GO:0036477|somatodendritic compartment;GO:0032588|trans-Golgi network membrane;","GO:0032051|clathrin light chain binding;",".","."]
["gene8746",60,362,219,201.530831843133,47,37,34,43.4187184987092,4.6415656383116,2.21461152036137,{"v":1.01202244785505e-08,"d":"1.01E-08"},{"v":1.065461714382e-06,"d":"1.07E-06"},"up","yes","SORCS2","protein_coding","chrNC_037333.1:113628521-114123632:+","gi|803244450|ref|XP_011982280.1|",5418,0,"PREDICTED: VPS10 domain-containing receptor SorCS2 isoform X2 [Ovis aries musimon]","gi|982983938|ref|XM_015463913.1|",3516,0,"PREDICTED: Bos taurus sortilin-related VPS10 domain containing receptor 2 (SORCS2), mRNA","Q96PQ0",1913,0,"VPS10 domain-containing receptor SorCS2",".",".",".",".","pfam00801","PKD","PKD domain. This domain was first identified in the Polycystic kidney disease protein PKD1. This domain has been predicted to contain an Ig-like fold.","GO:0007218|neuropeptide signaling pathway;","GO:0016021|integral component of membrane;GO:0016020|membrane;","GO:0008188|neuropeptide receptor activity;",".","."]
["gene8756",137,27,11,47.9320987548281,3,5,3,4.0391607808616,11.8668459502628,3.56886463167259,{"v":4.41855032996868e-07,"d":"4.42E-07"},{"v":3.01592486756786e-05,"d":"3.02E-05"},"up","yes","CPZ","protein_coding","chrNC_037333.1:114791982-114815409:+","gi|296486344|tpg|DAA28457.1|",3324,0,"TPA: carboxypeptidase Z [Bos taurus]","gi|402767084|ref|NM_001083486.2|",2075,0,"Bos taurus carboxypeptidase Z (CPZ), mRNA","Q66K79",1100,0,"Carboxypeptidase Z","BH3831",55.5,{"v":3e-07,"d":"3.00E-07"},"COG2866","pfam00246","Peptidase_M14","Zinc carboxypeptidase.","GO:0006518|peptide metabolic process;GO:0016485|protein processing;GO:0006508|proteolysis;GO:0016055|Wnt signaling pathway;","GO:0005615|extracellular space;","GO:0004181|metallocarboxypeptidase activity;GO:0004185|serine-type carboxypeptidase activity;GO:0008270|zinc ion binding;","K13022","CPZ; carboxypeptidase Z [EC:3.4.17.-]"]
["gene8881",1411,1055,1562,1193.2055304347,373,356,391,411.203471584421,2.9017399241235,1.53691821995897,{"v":1.57868375094431e-09,"d":"1.58E-09"},{"v":1.99923679002123e-07,"d":"2.00E-07"},"up","yes","ADAMTS2","protein_coding","chrNC_037334.1:2015432-2260679:+","gi|27807141|ref|NP_777056.1|",6014,0,"A disintegrin and metalloproteinase with thrombospondin motifs 2 precursor [Bos taurus]","gi|31341486|ref|NM_174631.2|",4559,0,"Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 2 (ADAMTS2), mRNA","P79331",2320,0,"A disintegrin and metalloproteinase with thrombospondin motifs 2",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0032964|collagen biosynthetic process;GO:0030574|collagen catabolic process;GO:0030199|collagen fibril organization;GO:0030324|lung development;GO:0016485|protein processing;GO:0043588|skin development;GO:0007283|spermatogenesis;GO:0097435|fibril organization;","GO:0005576|extracellular region;","GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K08618","ADAMTS2; a disintegrin and metalloproteinase with thrombospondin motifs 2 [EC:3.4.24.14]"]
["gene8892",317,335,163,242.463814889408,60,86,69,78.8941456474589,3.07328018954493,1.619779302772,{"v":2.64736906693827e-06,"d":"2.65E-06"},0.000137331066997847,"up","yes","HIST3H2A","protein_coding","chrNC_037334.1:2573757-2575265:+","gi|594079192|ref|XP_006063276.1|",573,{"v":4e-68,"d":"4.00E-68"},"PREDICTED: histone H2A type 3-like [Bubalus bubalis]","gi|402692966|ref|NM_001098097.2|",1500,0,"Bos taurus histone cluster 3, H2a (HIST3H2A), mRNA","Q8CGP6",213,{"v":3e-65,"d":"3.00E-65"},"Histone H2A type 1-H","SPAC19G12.06c",182,{"v":6e-54,"d":"6.00E-54"},"COG5262","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006342|chromatin silencing;","GO:0000790|nuclear chromatin;GO:0000786|nucleosome;","GO:0003677|DNA binding;GO:0046982|protein heterodimerization activity;","K11251","H2A; histone H2A"]
["gene8893",3,46,3,16.7782478548362,0,0,0,0,"Inf","Inf",{"v":9.51520098622826e-06,"d":"9.52E-06"},0.000411962437931964,"up","yes","LOC518318","protein_coding","chrNC_037334.1:2590530-2591231:+","gi|982929366|ref|XP_002688551.2|",1142,{"v":2e-156,"d":"2.00E-156"},"PREDICTED: histone H3.1 [Bos taurus]","gi|982983993|ref|XM_596506.6|",702,0,"PREDICTED: Bos taurus histone H3.1 (LOC518318), mRNA","Q6LED0",270,{"v":1e-90,"d":"1.00E-90"},"Histone H3.1",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006334|nucleosome assembly;","GO:0005654|nucleoplasm;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;","K11253","H3; histone H3"]
["gene8929",0,49,10,19.129382617204,0,0,0,0,"Inf","Inf",{"v":2.30765348735676e-06,"d":"2.31E-06"},0.000123248321883854,"up","yes","TSSK6","protein_coding","chrNC_037334.1:3810331-3811955:+","gi|440892284|gb|ELR45540.1|",1515,0,"Testis-specific serine/threonine-protein kinase 6, partial [Bos mutus]","gi|982984023|ref|XM_588888.7|",1625,0,"PREDICTED: Bos taurus testis-specific serine kinase 6 (TSSK6), mRNA","Q925K9",554,0,"Testis-specific serine/threonine-protein kinase 6",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0007275|multicellular organismal development;GO:0006468|protein phosphorylation;GO:0035092|sperm chromatin condensation;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;","K08811","TSSK, STK22; testis-specific serine kinase [EC:2.7.11.1]"]
["gene895",203,128,103,126.487908277829,59,37,53,54.7624204615394,2.30975744336691,1.20774135656553,0.00278410726899037,0.0390719943391856,"up","yes","SHOX2","protein_coding","chrNC_037328.1:109417705-109428087:+","gi|594113742|ref|XP_006079614.1|",1201,{"v":6e-153,"d":"6.00E-153"},"PREDICTED: short stature homeobox protein 2 isoform X2 [Bubalus bubalis]","gi|982911379|ref|XM_005201725.3|",3007,0,"PREDICTED: Bos taurus short stature homeobox 2 (SHOX2), transcript variant X1, mRNA","O60902",461,{"v":3e-152,"d":"3.00E-152"},"Short stature homeobox protein 2","ECU03g1170",55.1,{"v":2e-07,"d":"2.00E-07"},"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0003209|cardiac atrium morphogenesis;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0002063|chondrocyte development;GO:0048557|embryonic digestive tract morphogenesis;GO:0035115|embryonic forelimb morphogenesis;GO:0060272|embryonic skeletal joint morphogenesis;GO:0007507|heart development;GO:0003170|heart valve development;GO:0060415|muscle tissue morphogenesis;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0007399|nervous system development;GO:0001649|osteoblast differentiation;GO:0050772|positive regulation of axonogenesis;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0048743|positive regulation of skeletal muscle fiber development;GO:0045880|positive regulation of smoothened signaling pathway;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:2000172|regulation of branching morphogenesis of a nerve;GO:0032330|regulation of chondrocyte differentiation;GO:0001501|skeletal system development;","GO:0005634|nucleus;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;","K09331","SHOX; short stature homeobox protein"]
["gene8955",482,1380,1147,930.139311208643,233,350,311,327.796182468342,2.83755382446674,1.50464775859025,{"v":3.52861675328155e-08,"d":"3.53E-08"},{"v":3.34468320889954e-06,"d":"3.34E-06"},"up","yes","CRTC1","protein_coding","chrNC_037334.1:4430905-4516037:-","gi|528954340|ref|XP_005208500.1|",2898,0,"PREDICTED: CREB-regulated transcription coactivator 1 isoform X1 [Bos taurus]","gi|982929473|ref|XM_005208443.3|",7146,0,"PREDICTED: Bos taurus CREB regulated transcription coactivator 1 (CRTC1), transcript variant X1, mRNA","Q6UUV9",1012,0,"CREB-regulated transcription coactivator 1",".",".",".",".","pfam12885","TORC_M","Transducer of regulated CREB activity middle domain. This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterized, no functional role has been assigned to the central region, yet.","GO:0097009|energy homeostasis;GO:0043153|entrainment of circadian clock by photoperiod;GO:0007613|memory;GO:1902631|negative regulation of membrane hyperpolarization;GO:0032793|positive regulation of CREB transcription factor activity;GO:1900006|positive regulation of dendrite development;GO:1900273|positive regulation of long-term synaptic potentiation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0051289|protein homotetramerization;GO:0048511|rhythmic process;GO:0006351|transcription, DNA-templated;GO:0016032|viral process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030425|dendrite;GO:0043025|neuronal cell body;GO:0016604|nuclear body;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0008140|cAMP response element binding protein binding;","K15309","CRTC1, TORC1; CREB-regulated transcription coactivator 1"]
["gene8959",15,18,298,101.330513593476,16,6,15,13.5968081836934,7.45252210846081,2.89772875008487,{"v":2.61267253457711e-07,"d":"2.61E-07"},{"v":1.90644910700817e-05,"d":"1.91E-05"},"up","yes","TMEM59L","protein_coding","chrNC_037334.1:4576424-4582333:-","gi|115496940|ref|NP_001068769.1|",1589,0,"transmembrane protein 59-like precursor [Bos taurus]","gi|115496939|ref|NM_001075301.1|",1594,0,"Bos taurus transmembrane protein 59 like (TMEM59L), mRNA","Q0VCT2",617,0,"Transmembrane protein 59-like",".",".",".",".","pfam12280","BSMAP","Brain specific membrane anchored protein. This family of proteins is found in eukaryotes. Proteins in this family are typically between 285 and 331 amino acids in length. BSMAP has a putative transmembrane domain and is predicted to be a type I membrane glycoprotein.",".","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;",".",".","."]
["gene898",91,321,1108,469.204859615188,37,12,32,29.7844025952178,15.7533748785185,3.9775890281936,{"v":3.62383076097571e-09,"d":"3.62E-09"},{"v":4.20290713176414e-07,"d":"4.20E-07"},"up","yes","PTX3","protein_coding","chrNC_037328.1:110158197-110164262:-","gi|742117937|ref|XP_010838164.1|",1944,0,"PREDICTED: pentraxin-related protein PTX3 [Bison bison bison]","gi|402691645|ref|NM_001076259.2|",1840,0,"Bos taurus pentraxin 3 (PTX3), mRNA","Q0VCG9",751,0,"Pentraxin-related protein PTX3",".",".",".",".","pfam00354","Pentaxin","Pentaxin family. Pentaxins are also known as pentraxins.",".","GO:0005576|extracellular region;",".",".","."]
["gene8984",2551,2897,2534,2392.4942133936,445,459,453,498.294812767747,4.80136287212111,2.26344397453563,{"v":3.22284899371919e-20,"d":"3.22E-20"},{"v":2.25961537142398e-17,"d":"2.26E-17"},"up","yes","PDE4C","protein_coding","chrNC_037334.1:5001543-5013726:+","gi|742149439|ref|XP_010843965.1|",3530,0,"PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [Bison bison bison]","gi|982929607|ref|XM_005208506.3|",3160,0,"PREDICTED: Bos taurus phosphodiesterase 4C (PDE4C), transcript variant X2, mRNA","Q08493",1074,0,"cAMP-specific 3',5'-cyclic phosphodiesterase 4C",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0006198|cAMP catabolic process;GO:0007186|G-protein coupled receptor signaling pathway;","GO:0005929|cilium;GO:0005829|cytosol;GO:0005615|extracellular space;","GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0046872|metal ion binding;","K13293","PDE4; cAMP-specific phosphodiesterase 4 [EC:3.1.4.53]"]
["gene8985",149,319,160,192.514263332795,60,100,71,84.7539173902176,2.27144973661141,1.18361338131639,0.00134781207644169,0.0228935872769163,"up","yes","RAB3A","protein_coding","chrNC_037334.1:5018104-5023793:+","gi|635037060|ref|XP_007993972.1|",1239,{"v":9e-166,"d":"9.00E-166"},"PREDICTED: ras-related protein Rab-3A [Chlorocebus sabaeus]","gi|110350676|ref|NM_174446.3|",1437,0,"Bos taurus RAB3A, member RAS oncogene family (RAB3A), mRNA","P11023",456,{"v":1e-158,"d":"1.00E-158"},"Ras-related protein Rab-3A",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0007409|axonogenesis;GO:0061670|evoked neurotransmitter secretion;GO:0030324|lung development;GO:0048790|maintenance of presynaptic active zone structure;GO:0007005|mitochondrion organization;GO:0007274|neuromuscular synaptic transmission;GO:1903307|positive regulation of regulated secretory pathway;GO:0009791|post-embryonic development;GO:0015031|protein transport;GO:0017157|regulation of exocytosis;GO:0048172|regulation of short-term neuronal synaptic plasticity;GO:0031630|regulation of synaptic vesicle fusion to presynaptic membrane;GO:0003016|respiratory system process;GO:0051602|response to electrical stimulus;GO:0050975|sensory perception of touch;GO:0016079|synaptic vesicle exocytosis;GO:0016188|synaptic vesicle maturation;","GO:0001669|acrosomal vesicle;GO:0005768|endosome;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0008021|synaptic vesicle;GO:0043195|terminal bouton;","GO:0005525|GTP binding;GO:0030742|GTP-dependent protein binding;GO:0003924|GTPase activity;GO:0031489|myosin V binding;","K07882","RAB3A; Ras-related protein Rab-3A"]
["gene9001",720,295,307,378.611787405704,120,123,141,140.888819079795,2.68730897085076,1.4261622034085,{"v":2.96619039636086e-06,"d":"2.97E-06"},0.000151663760212494,"up","yes","B3GNT3","protein_coding","chrNC_037334.1:5344434-5364510:-","gi|148540320|ref|NP_001091943.1|",1894,0,"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 precursor [Bos taurus]","gi|982929648|ref|XM_005208530.3|",2379,0,"PREDICTED: Bos taurus UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (B3GNT3), transcript variant X1, mRNA","Q9Y2A9",533,0,"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3",".",".",".",".","pfam01762","Galactosyl_T","Galactosyltransferase. This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2.","GO:0018146|keratan sulfate biosynthetic process;GO:0016266|O-glycan processing;GO:0030311|poly-N-acetyllactosamine biosynthetic process;","GO:0000139|Golgi membrane;GO:0005887|integral component of plasma membrane;","GO:0047223|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity;GO:0008532|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity;GO:0008499|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;","K07970","B3GNT3; beta-1,3-N-acetylglucosaminyltransferase 3 [EC:2.4.1.-]"]
["gene9018",690,693,502,561.113445178421,224,271,245,271.616041068598,2.06583323639824,1.04672379789526,0.000201923091311692,0.00511186132938233,"up","yes","ANO8","protein_coding","chrNC_037334.1:5794341-5805234:+","gi|594068198|ref|XP_006058030.1|",2430,0,"PREDICTED: LOW QUALITY PROTEIN: anoctamin-8 [Bubalus bubalis]","gi|982984145|ref|XM_015463966.1|",4013,0,"PREDICTED: Bos taurus anoctamin 8 (ANO8), transcript variant X2, mRNA","Q9HCE9",919,0,"Anoctamin-8",".",".",".",".","pfam04547","Anoctamin","Calcium-activated chloride channel. The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.","GO:0044267|cellular protein metabolic process;GO:0006821|chloride transport;GO:0034220|ion transmembrane transport;GO:0043687|post-translational protein modification;","GO:0005788|endoplasmic reticulum lumen;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005229|intracellular calcium activated chloride channel activity;","K19502","ANO8, TMEM16H; anoctamin-8"]
["gene9039",6100,9052,11039,7946.61789027879,2283,3630,2958,3253.23522936846,2.44268161691506,1.28846583264678,{"v":2.22894989049979e-05,"d":"2.23E-05"},0.000831932667725762,"up","yes","TMEM38A","protein_coding","chrNC_037334.1:6356470-6382966:-","gi|556734664|ref|XP_005962959.1|",1194,{"v":3e-155,"d":"3.00E-155"},"PREDICTED: trimeric intracellular cation channel type A [Pantholops hodgsonii]","gi|134085861|ref|NM_001083463.1|",2276,0,"Bos taurus transmembrane protein 38A (TMEM38A), mRNA","A4FV75",464,{"v":1e-156,"d":"1.00E-156"},"Trimeric intracellular cation channel type A",".",".",".",".","pfam05197","TRIC","TRIC channel. TRIC (trimeric intracellular cation) channels are differentially expressed in intracellular stores in animal cell types. TRIC subtypes contain three proposed transmembrane segments, and form homo-trimers with a bullet-like structure. Electrophysiological measurements with purified TRIC preparations identify a monovalent cation-selective channel.",".","GO:0016021|integral component of membrane;GO:0031965|nuclear membrane;GO:0033017|sarcoplasmic reticulum membrane;","GO:0015269|calcium-activated potassium channel activity;",".","."]
["gene9077",56,144,153,108.775857010617,1,4,2,2.56366414304914,42.4298390666893,5.40700730148844,{"v":6.95939347668019e-19,"d":"6.96E-19"},{"v":4.22464798474814e-16,"d":"4.22E-16"},"up","yes","LOC513779","pseudogene","chrNC_037334.1:7363933-7382318:-","gi|556734638|ref|XP_005962947.1|",1384,0,"PREDICTED: cytochrome P450 4F11-like [Pantholops hodgsonii]","gi|965935708|ref|XM_012177744.2|",989,0,"PREDICTED: Ovis aries phylloquinone omega-hydroxylase CYP4F2-like (LOC105613870), transcript variant X2, mRNA","P78329",445,0,"Phylloquinone omega-hydroxylase CYP4F2","alr4766",105,{"v":1e-29,"d":"1.00E-29"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0019369|arachidonic acid metabolic process;GO:0007596|blood coagulation;GO:0017144|drug metabolic process;GO:0019373|epoxygenase P450 pathway;GO:0006690|icosanoid metabolic process;GO:0036101|leukotriene B4 catabolic process;GO:0006691|leukotriene metabolic process;GO:0001676|long-chain fatty acid metabolic process;GO:0042361|menaquinone catabolic process;GO:0032304|negative regulation of icosanoid secretion;GO:0097267|omega-hydroxylase P450 pathway;GO:0055114|oxidation-reduction process;GO:0042376|phylloquinone catabolic process;GO:0032305|positive regulation of icosanoid secretion;GO:0003095|pressure natriuresis;GO:0008217|regulation of blood pressure;GO:0003091|renal water homeostasis;GO:0055078|sodium ion homeostasis;GO:0000038|very long-chain fatty acid metabolic process;GO:0042360|vitamin E metabolic process;GO:0042377|vitamin K catabolic process;","GO:0016324|apical plasma membrane;GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0031090|organelle membrane;","GO:0097259|20-aldehyde-leukotriene B4 20-monooxygenase activity;GO:0097258|20-hydroxy-leukotriene B4 omega oxidase activity;GO:0018685|alkane 1-monooxygenase activity;GO:0052871|alpha-tocopherol omega-hydroxylase activity;GO:0008392|arachidonic acid epoxygenase activity;GO:0052869|arachidonic acid omega-hydroxylase activity;GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0050051|leukotriene-B4 20-monooxygenase activity;GO:0004497|monooxygenase activity;GO:0016709|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0052872|tocotrienol omega-hydroxylase activity;","K17726","CYP4F2_3; leukotriene-B4 20-monooxygenase / phylloquinone omega-hydroxylase [EC:1.14.13.30 1.14.13.194]"]
["gene9094",2206,1223,1562,1455.4575738262,444,576,539,571.902258656306,2.54494111851528,1.34763227751563,{"v":6.601734058203e-08,"d":"6.60E-08"},{"v":5.77773234400582e-06,"d":"5.78E-06"},"up","yes","NOTCH3","protein_coding","chrNC_037334.1:7910713-7950469:+","gi|359066825|ref|XP_003586294.1|",10534,0,"PREDICTED: neurogenic locus notch homolog protein 3 [Bos taurus]","gi|982984233|ref|XM_015463984.1|",8077,0,"PREDICTED: Bos taurus notch 3 (NOTCH3), mRNA","Q9UM47",3753,0,"Neurogenic locus notch homolog protein 3","TVN1399",66.6,{"v":7e-11,"d":"7.00E-11"},"COG0666","pfam07684","NODP","NOTCH protein. NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.","GO:0048844|artery morphogenesis;GO:0030900|forebrain development;GO:0072104|glomerular capillary formation;GO:0045665|negative regulation of neuron differentiation;GO:0045746|negative regulation of Notch signaling pathway;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0048663|neuron fate commitment;GO:0007219|Notch signaling pathway;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0007221|positive regulation of transcription of Notch receptor target;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0015629|actin cytoskeleton;GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;GO:0005576|extracellular region;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0043235|receptor complex;","GO:0045296|cadherin binding;GO:0005509|calcium ion binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0038023|signaling receptor activity;",".","."]
["gene9236",278,776,662,530.076700353345,63,29,71,59.8191042625217,8.8613279467886,3.1475229153365,{"v":4.64427808085768e-09,"d":"4.64E-09"},{"v":5.24471651540594e-07,"d":"5.24E-07"},"up","yes","ADGRL1","protein_coding","chrNC_037334.1:11510479-11560787:+","gi|741931769|ref|XP_010805002.1|",6651,0,"PREDICTED: adhesion G protein-coupled receptor L1 isoform X3 [Bos taurus]","gi|982930001|ref|XM_010806700.2|",7528,0,"PREDICTED: Bos taurus adhesion G protein-coupled receptor L1 (ADGRL1), transcript variant X4, mRNA","O97831",2564,0,"Adhesion G protein-coupled receptor L1",".",".",".",".","pfam02354","Latrophilin","Latrophilin Cytoplasmic C-terminal region. This family consists of the cytoplasmic C-terminal region in latrophilin. Latrophilin is a synaptic Ca2+ independent alpha- latrotoxin (LTX) receptor and is a novel member of the secretin family of G-protein coupled receptors that are involved in secretion. Latrophilin mRNA is present only in neuronal tissue. Lactrophillin interacts with G-alpha O.","GO:0035584|calcium-mediated signaling using intracellular calcium source;GO:0007166|cell surface receptor signaling pathway;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0090129|positive regulation of synapse maturation;","GO:0030424|axon;GO:0030054|cell junction;GO:0030426|growth cone;GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0043005|neuron projection;GO:0005886|plasma membrane;GO:0042734|presynaptic membrane;GO:0045202|synapse;","GO:0030246|carbohydrate binding;GO:0050839|cell adhesion molecule binding;GO:0004930|G-protein coupled receptor activity;GO:0016524|latrotoxin receptor activity;","K04592","LPHN1; latrophilin 1"]
["gene9242",201,451,546,367.874355876275,72,113,103,105.561105299803,3.48494225057116,1.80113474920563,{"v":1.90077281699507e-08,"d":"1.90E-08"},{"v":1.8941154195917e-06,"d":"1.89E-06"},"up","yes","MISP3","protein_coding","chrNC_037334.1:11623511-11627168:-","gi|528906818|ref|XP_589610.6|",708,{"v":2e-87,"d":"2.00E-87"},"PREDICTED: uncharacterized protein LOC539805 [Bos taurus]","gi|982984404|ref|XM_015464031.1|",1384,0,"PREDICTED: Bos taurus uncharacterized LOC539805 (LOC539805), transcript variant X2, mRNA",".",".",".",".",".",".",".",".","pfam15304","AKAP2_C","A-kinase anchor protein 2 C-terminus. This family includes the C-terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds.",".",".",".",".","."]
["gene9247",561,1201,1052,862.890527147954,286,338,317,345.367877750987,2.4984678157304,1.32104363396925,{"v":1.20240142064081e-06,"d":"1.20E-06"},{"v":7.1769278101052e-05,"d":"7.18E-05"},"up","yes","RFX1","protein_coding","chrNC_037334.1:11690530-11725951:+","gi|759190847|ref|XP_011382772.1|",4278,0,"PREDICTED: MHC class II regulatory factor RFX1 isoform X3 [Pteropus vampyrus]","gi|965860661|ref|XM_012144897.2|",3517,0,"PREDICTED: Ovis aries musimon regulatory factor X1 (RFX1), transcript variant X2, mRNA","P22670",1177,0,"MHC class II regulatory factor RFX1",".",".",".",".","pfam02257","RFX_DNA_binding","RFX DNA-binding domain. RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD).","GO:0006955|immune response;GO:0006351|transcription, DNA-templated;","GO:0043231|intracellular membrane-bounded organelle;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;","K09173","RFX1_2_3; regulatory factor X 1/2/3"]
["gene9277",14130,22829,22140,17963.7462031863,7841,8051,8495,8951.79720048398,2.00671952244573,1.00483898647947,0.000775474427336893,0.0148990308998983,"up","yes","NFIX","protein_coding","chrNC_037334.1:12479744-12575894:-","gi|594034278|ref|XP_006041853.1|",2446,0,"PREDICTED: nuclear factor 1 X-type isoform X7 [Bubalus bubalis]","gi|821404319|ref|XM_004277448.2|",3466,0,"PREDICTED: Orcinus orca nuclear factor I/X (CCAAT-binding transcription factor) (NFIX), transcript variant X1, mRNA","Q14938",889,0,"Nuclear factor 1 X-type",".",".",".",".","pfam00859","CTF_NFI","CTF/NF-I family transcription modulation region.","GO:0006260|DNA replication;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;","K09171","NFIX; nuclear factor I/X"]
["gene9291",331,598,334,384.820089183434,83,122,101,112.253496635835,3.42813454116124,1.77742373082065,{"v":1.59436600206986e-08,"d":"1.59E-08"},{"v":1.62460201446626e-06,"d":"1.62E-06"},"up","yes","RNASEH2A","protein_coding","chrNC_037334.1:12722240-12730210:-","gi|84370099|ref|NP_001033623.1|",1591,0,"ribonuclease H2 subunit A [Bos taurus]","gi|942068802|ref|XM_014479714.1|",1714,0,"PREDICTED: Bos mutus ribonuclease H2, subunit A (RNASEH2A), transcript variant X2, mRNA","Q2TBT5",617,0,"Ribonuclease H2 subunit A","SPAC4G9.02",197,{"v":3e-55,"d":"3.00E-55"},"COG0164","pfam01351","RNase_HII","Ribonuclease HII.","GO:0043137|DNA replication, removal of RNA primer;GO:0006298|mismatch repair;GO:0006401|RNA catabolic process;","GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0032299|ribonuclease H2 complex;","GO:0046872|metal ion binding;GO:0003723|RNA binding;GO:0004523|RNA-DNA hybrid ribonuclease activity;","K10743","RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]"]
["gene9297",3001,3071,3818,2961.14172370465,842,1196,851,1060.81779252076,2.79137637451221,1.48097666293262,{"v":1.66977701937865e-07,"d":"1.67E-07"},{"v":1.30629790997099e-05,"d":"1.31E-05"},"up","yes","TRIR","protein_coding","chrNC_037334.1:12781048-12784169:+","gi|803280968|ref|XP_012000179.1|",447,{"v":3e-50,"d":"3.00E-50"},"PREDICTED: uncharacterized protein C19orf43 homolog isoform X2 [Ovis aries musimon]","gi|402693428|ref|NM_001083371.2|",876,0,"Bos taurus chromosome 7 open reading frame, human C19orf43 (C7H19orf43), mRNA","Q9BQ61",164,{"v":7e-48,"d":"7.00E-48"},"Telomerase RNA component interacting RNase",".",".",".",".","pfam13503","DUF4123","Domain of unknown function (DUF4123). This presumed domain is functionally uncharacterized. It is about 120 amino acids in length and contains several conserved motifs that may be functionally important. This domain is sometimes associated with the FHA domain.","GO:0090503|RNA phosphodiester bond hydrolysis, exonucleolytic;GO:0016075|rRNA catabolic process;",".","GO:0008408|3'-5' exonuclease activity;GO:0008409|5'-3' exonuclease activity;GO:0003723|RNA binding;",".","."]
["gene9316",4,33,0,11.8571763611624,0,0,0,0,"Inf","Inf",0.000190446621961305,0.00486013646795884,"up","yes","MUC16","protein_coding","chrNC_037334.1:13194439-13313467:-","gi|741931907|ref|XP_010805044.1|",15874,0,"PREDICTED: mucin-16 isoform X1 [Bos taurus]","gi|982984515|ref|XM_002704770.5|",11721,0,"PREDICTED: Bos taurus mucin 16, cell surface associated (MUC16), transcript variant X9, mRNA","Q8WXI7",1953,0,"Mucin-16",".",".",".",".","pfam01390","SEA","SEA domain. Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.","GO:0007155|cell adhesion;GO:0016266|O-glycan processing;GO:0002223|stimulatory C-type lectin receptor signaling pathway;","GO:0070062|extracellular exosome;GO:0019898|extrinsic component of membrane;GO:0005796|Golgi lumen;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0031982|vesicle;",".",".","."]
["gene9378",33,54,55,43.1890113411965,16,6,11,12.1529166298805,3.55379804342664,1.82936169767905,0.00316238167143304,0.042903429133455,"up","yes","OLFM2","protein_coding","chrNC_037334.1:14446718-14453791:-","gi|676274193|gb|KFO28742.1|",2424,0,"Noelin-2 [Fukomys damarensis]","gi|328927021|ref|NM_001205320.1|",1791,0,"Bos taurus olfactomedin 2 (OLFM2), mRNA","Q568Y7",905,0,"Noelin-2",".",".",".",".","pfam02191","OLF","Olfactomedin-like domain.","GO:0007626|locomotory behavior;GO:0051152|positive regulation of smooth muscle cell differentiation;GO:0009306|protein secretion;GO:0007601|visual perception;","GO:0032281|AMPA glutamate receptor complex;GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0097060|synaptic membrane;",".",".","."]
["gene9382",3287,1898,3848,2660.48078073871,1202,1139,1253,1319.56711471312,2.01617693490119,1.01162225188522,{"v":4.31677244748428e-05,"d":"4.32E-05"},0.00142036241547423,"up","yes","COL5A3","protein_coding","chrNC_037334.1:14542635-14587337:-","gi|528955128|ref|XP_005208792.1|",1456,{"v":2e-165,"d":"2.00E-165"},"PREDICTED: collagen alpha-3(V) chain isoform X4 [Bos taurus]","gi|982930381|ref|XM_005208735.3|",6255,0,"PREDICTED: Bos taurus collagen type V alpha 3 (COL5A3), transcript variant X4, mRNA","P25940",441,{"v":3e-125,"d":"3.00E-125"},"Collagen alpha-3(V) chain",".",".",".",".","pfam01410","COLFI","Fibrillar collagen C-terminal domain. Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.","GO:0007160|cell-matrix adhesion;GO:0030199|collagen fibril organization;GO:0030198|extracellular matrix organization;GO:0043588|skin development;","GO:0005588|collagen type V trimer;GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;","GO:0005518|collagen binding;GO:0005201|extracellular matrix structural constituent;GO:0008201|heparin binding;GO:0043394|proteoglycan binding;",".","."]
["gene9417",4631,4574,5275,4325.99349176218,1839,1721,1832,1980.24745572717,2.18457217518485,1.12735077117977,{"v":7.1003476560895e-06,"d":"7.10E-06"},0.000320538004708686,"up","yes","SLC44A2","protein_coding","chrNC_037334.1:15097944-15130758:+","gi|528955239|ref|XP_005208847.1|",3457,0,"PREDICTED: choline transporter-like protein 2 isoform X1 [Bos taurus]","gi|741932172|ref|XM_005208790.2|",3771,0,"PREDICTED: Bos taurus solute carrier family 44 (choline transporter), member 2 (SLC44A2), transcript variant X1, mRNA","A5D7H3",1293,0,"Choline transporter-like protein 2",".",".",".",".","pfam04515","Choline_transpo","Plasma-membrane choline transporter. This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals.",".","GO:0016021|integral component of membrane;",".","K15377","SLC44A2_4_5; solute carrier family 44 (choline transporter-like protein), member 2/4/5"]
["gene9437",424,471,527,426.712380236328,171,105,128,148.652567887522,2.87053487403729,1.52131958297202,{"v":1.30250362858186e-05,"d":"1.30E-05"},0.000535471628632119,"up","yes","LDLR","protein_coding","chrNC_037334.1:15545318-15579082:+","gi|262073126|ref|NP_001160002.1|",4236,0,"low-density lipoprotein receptor precursor [Bos taurus]","gi|262073125|ref|NM_001166530.1|",4359,0,"Bos taurus low density lipoprotein receptor (LDLR), mRNA","P01131",1637,0,"Low-density lipoprotein receptor",".",".",".",".","pfam00057","Ldl_recept_a","Low-density lipoprotein receptor domain class A.","GO:0097242|beta-amyloid clearance;GO:0071398|cellular response to fatty acid;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0042632|cholesterol homeostasis;GO:0070508|cholesterol import;GO:0008203|cholesterol metabolic process;GO:0030299|intestinal cholesterol absorption;GO:0042159|lipoprotein catabolic process;GO:0007616|long-term memory;GO:0034383|low-density lipoprotein particle clearance;GO:0010629|negative regulation of gene expression;GO:1903979|negative regulation of microglial cell activation;GO:0015914|phospholipid transport;GO:1900223|positive regulation of beta-amyloid clearance;GO:0045807|positive regulation of endocytosis;GO:0010628|positive regulation of gene expression;GO:0050729|positive regulation of inflammatory response;GO:0010986|positive regulation of lipoprotein particle clearance;GO:0010867|positive regulation of triglyceride biosynthetic process;GO:0090118|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport;GO:0090181|regulation of cholesterol metabolic process;GO:0010899|regulation of phosphatidylcholine catabolic process;","GO:0045177|apical part of cell;GO:0016323|basolateral plasma membrane;GO:0005901|caveola;GO:0009986|cell surface;GO:0005905|coated pit;GO:0005769|early endosome;GO:0009897|external side of plasma membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0005770|late endosome;GO:0034362|low-density lipoprotein particle;GO:0005764|lysosome;GO:0005771|multivesicular body;GO:1990666|PCSK9-LDLR complex;GO:0043235|receptor complex;GO:0036477|somatodendritic compartment;GO:0097443|sorting endosome;","GO:0001540|beta-amyloid binding;GO:0005509|calcium ion binding;GO:0042802|identical protein binding;GO:0030169|low-density lipoprotein particle binding;GO:0005041|low-density lipoprotein receptor activity;GO:0002020|protease binding;GO:0030229|very-low-density lipoprotein particle receptor activity;","K12473","LDLR; low-density lipoprotein receptor"]
["gene9508",1407,332,279,561.186099501798,171,192,209,209.819290354316,2.67461632604961,1.41933195162398,{"v":1.76858019684252e-06,"d":"1.77E-06"},{"v":9.97220584903435e-05,"d":"9.97E-05"},"up","yes","KANK3","protein_coding","chrNC_037334.1:16969360-16980814:-","gi|528955435|ref|XP_005208921.1|",2844,0,"PREDICTED: KN motif and ankyrin repeat domain-containing protein 3 isoform X1 [Bos taurus]","gi|982930684|ref|XM_010806916.2|",4034,0,"PREDICTED: Bos taurus KN motif and ankyrin repeat domains 3 (KANK3), transcript variant X3, mRNA",".",".",".",".","RSc1788",70.5,{"v":5e-12,"d":"5.00E-12"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["gene9523",0,25,0,8.19294198016479,0,0,0,0,"Inf","Inf",0.00195165313495599,0.0302458531197335,"up","yes","ACTL9","protein_coding","chrNC_037334.1:17250900-17252340:-","gi|84370177|ref|NP_001033658.1|",2136,0,"actin-like protein 9 [Bos taurus]","gi|402744029|ref|NM_001038569.2|",1441,0,"Bos taurus actin like 9 (ACTL9), mRNA","Q2T9W4",827,0,"Actin-like protein 9","SPBC32H8.12c",309,{"v":2e-99,"d":"2.00E-99"},"COG5277","pfam00022","Actin","Actin.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;",".",".","."]
["gene9568",1,53,0,17.6296602347856,1,1,4,2.18464721298729,8.06979732470341,3.01253244025434,0.00306795751984748,0.0420422170983518,"up","yes","ACSBG2","protein_coding","chrNC_037334.1:18226446-18275767:-","gi|194668334|ref|XP_001790634.1|",3555,0,"PREDICTED: long-chain-fatty-acid--CoA ligase ACSBG2 [Bos taurus]","gi|982984806|ref|XM_001790582.5|",2277,0,"PREDICTED: Bos taurus acyl-CoA synthetase bubblegum family member 2 (ACSBG2), mRNA","Q5FVE4",1015,0,"Long-chain-fatty-acid--CoA ligase ACSBG2","VC2484",242,{"v":4e-68,"d":"4.00E-68"},"COG1022","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0030154|cell differentiation;GO:0006631|fatty acid metabolic process;GO:0035338|long-chain fatty-acyl-CoA biosynthetic process;GO:0007275|multicellular organismal development;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0016020|membrane;GO:0005739|mitochondrion;","GO:0047617|acyl-CoA hydrolase activity;GO:0005524|ATP binding;GO:0004467|long-chain fatty acid-CoA ligase activity;GO:0031957|very long-chain fatty acid-CoA ligase activity;","K15013","ACSBG; long-chain-fatty-acid--CoA ligase ACSBG [EC:6.2.1.3]"]
["gene9579",25,13,4,12.0043972850234,0,1,0,0.366987568989444,32.7106373604951,5.03168796521808,0.000639687354423971,0.0129164330566669,"up","yes","LOC112447617","snoRNA","chrNC_037334.1:18550534-18550613:+",".",".",".",".","gi|850493339|gb|CP011906.1|",71,{"v":5e-28,"d":"5.00E-28"},"Ovis canadensis canadensis isolate 43U chromosome 21 sequence",".",".",".",".",".",".",".",".","pfam03471","CorC_HlyC","Transporter associated domain. This small domain is found in a family of proteins with the pfam01595 domain and two CBS domains with this domain found at the C-terminus of the proteins, the domain is also found at the C terminus of some Na+/H+ antiporters. This domain is also found in CorC that is involved in Magnesium and cobalt efflux. The function of this domain is uncertain but might be involved in modulating transport of ion substrates.",".",".",".",".","."]
["gene9594",0,22,0,7.20978894254502,0,0,0,0,"Inf","Inf",0.00366327422936877,0.0478557129295423,"up","yes","ZNRF4","protein_coding","chrNC_037334.1:18836615-18838843:+","gi|982930731|ref|XP_015327542.1|",1704,0,"PREDICTED: zinc/RING finger protein 4 [Bos taurus]","gi|942095123|ref|XM_005909008.2|",1548,0,"PREDICTED: Bos mutus zinc and ring finger 4 (ZNRF4), mRNA","Q4R6Y5",442,{"v":9e-149,"d":"9.00E-149"},"E3 ubiquitin-protein ligase ZNRF4",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0016567|protein ubiquitination;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;GO:0016740|transferase activity;","K15715","ZNRF4; Zinc/RING finger protein 4"]
["gene9609",523,111,177,227.043144405904,71,63,87,81.0623925448938,2.8008443530724,1.48586181301264,{"v":3.48806466039239e-05,"d":"3.49E-05"},0.00119326106505582,"up","yes","TNFAIP8L1","protein_coding","chrNC_037334.1:19483678-19503073:-","gi|157074058|ref|NP_001096740.1|",702,{"v":1e-82,"d":"1.00E-82"},"tumor necrosis factor alpha-induced protein 8-like protein 1 [Bos taurus]","gi|982930882|ref|XM_010806984.2|",2737,0,"PREDICTED: Bos taurus TNF alpha induced protein 8 like 1 (TNFAIP8L1), transcript variant X1, mRNA","A5PK29",275,{"v":5e-84,"d":"5.00E-84"},"Tumor necrosis factor alpha-induced protein 8-like protein 1",".",".",".",".","pfam05527","DUF758","Domain of unknown function (DUF758). Family of eukaryotic proteins with unknown function, which are induced by tumor necrosis factor.","GO:0032007|negative regulation of TOR signaling;GO:0042981|regulation of apoptotic process;","GO:0005737|cytoplasm;",".",".","."]
["gene9687",440,287,792,451.969531957841,135,125,115,137.844020470763,3.27884757288913,1.71318883526303,{"v":1.99748248621439e-08,"d":"2.00E-08"},{"v":1.96517837290286e-06,"d":"1.97E-06"},"up","yes","GADD45B","protein_coding","chrNC_037334.1:21118048-21120156:-","gi|119589783|gb|EAW69377.1|",716,{"v":3e-89,"d":"3.00E-89"},"growth arrest and DNA-damage-inducible, beta, isoform CRA_b, partial [Homo sapiens]","gi|87578266|gb|BC113347.1|",1330,0,"Bos taurus growth arrest and DNA-damage-inducible, beta, mRNA (cDNA clone MGC:138134 IMAGE:8086930), complete cds","Q5E9A5",271,{"v":1e-87,"d":"1.00E-87"},"Growth arrest and DNA damage-inducible protein GADD45 beta",".",".",".",".","pfam01248","Ribosomal_L7Ae","Ribosomal protein L7Ae/L30e/S12e/Gadd45 family. This family includes: Ribosomal L7A from metazoa, Ribosomal L8-A and L8-B from fungi, 30S ribosomal protein HS6 from archaebacteria, 40S ribosomal protein S12 from eukaryotes, Ribosomal protein L30 from eukaryotes and archaebacteria. Gadd45 and MyD118.","GO:0000186|activation of MAPKK activity;GO:0000185|activation of MAPKKK activity;GO:0006915|apoptotic process;GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0006469|negative regulation of protein kinase activity;GO:0043065|positive regulation of apoptotic process;GO:0046330|positive regulation of JNK cascade;GO:1900745|positive regulation of p38MAPK cascade;GO:0051726|regulation of cell cycle;GO:0006950|response to stress;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".","K04402","GADD45; growth arrest and DNA-damage-inducible protein"]
["gene9689",551,720,733,604.680289960237,179,212,233,228.812535778462,2.64268864423447,1.40200645983411,{"v":6.1625353224943e-07,"d":"6.16E-07"},{"v":4.04191483416287e-05,"d":"4.04E-05"},"up","yes","LMNB2","protein_coding","chrNC_037334.1:21134167-21154517:+","gi|444741701|ref|NP_001263282.1|",2346,0,"lamin-B2 [Bos taurus]","gi|444741700|ref|NM_001276353.1|",4619,0,"Bos taurus lamin B2 (LMNB2), mRNA","Q03252",798,0,"Lamin-B2",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".","GO:0005638|lamin filament;GO:0005637|nuclear inner membrane;GO:0031965|nuclear membrane;","GO:0005198|structural molecule activity;","K07611","LMNB; lamin B"]
["gene9745",335,63,58,125.768052879416,62,39,37,50.8421336548211,2.47369738125634,1.30666901960915,0.00302909429340854,0.0416496815832477,"up","yes","CHSY3","protein_coding","chrNC_037334.1:23975396-24263996:-","gi|300798440|ref|NP_001179581.1|",4170,0,"chondroitin sulfate synthase 3 [Bos taurus]","gi|300798439|ref|NM_001192652.1|",3490,0,"Bos taurus chondroitin sulfate synthase 3 (CHSY3), mRNA","Q70JA7",1528,0,"Chondroitin sulfate synthase 3",".",".",".",".","pfam05679","CHGN","Chondroitin N-acetylgalactosaminyltransferase.","GO:0030206|chondroitin sulfate biosynthetic process;","GO:0032580|Golgi cisterna membrane;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0047238|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity;GO:0046872|metal ion binding;GO:0050510|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity;","K13499","CHSY; chondroitin sulfate synthase [EC:2.4.1.175 2.4.1.226]"]
["gene9755",2462,3989,2684,2773.23469604999,1089,662,782,932.260019652786,2.97474378133566,1.57276541251638,{"v":1.61526764448773e-05,"d":"1.62E-05"},0.000636535927691706,"up","yes","SLC12A2","protein_coding","chrNC_037334.1:25758860-25853058:-","gi|803073562|ref|XP_012033566.1|",5615,0,"PREDICTED: solute carrier family 12 member 2 isoform X1 [Ovis aries]","gi|741932906|ref|XM_005209086.2|",6805,0,"PREDICTED: Bos taurus solute carrier family 12 (sodium/potassium/chloride transporter), member 2 (SLC12A2), transcript variant X1, mRNA","P55011",2058,0,"Solute carrier family 12 member 2","SPBC18H10.16",261,{"v":3e-70,"d":"3.00E-70"},"COG0531","pfam00324","AA_permease","Amino acid permease.","GO:0007568|aging;GO:0015696|ammonium transport;GO:0007214|gamma-aminobutyric acid signaling pathway;GO:0006972|hyperosmotic response;GO:0006811|ion transport;GO:0045795|positive regulation of cell volume;GO:0070634|transepithelial ammonium transport;GO:0030321|transepithelial chloride transport;","GO:0016324|apical plasma membrane;GO:0070062|extracellular exosome;GO:1903561|extracellular vesicle;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0008519|ammonium transmembrane transporter activity;GO:0019901|protein kinase binding;GO:0008511|sodium:potassium:chloride symporter activity;","K10951","SLC12A2, NKCC1; solute carrier family 12 (sodium/potassium/chloride transporter), member 2"]
["gene9764",159,259,483,274.657722604178,112,72,68,92.8312874827674,2.95867621845882,1.56495182441885,0.000181118292329813,0.0046764579171601,"up","yes","2020-03-03","protein_coding","chrNC_037334.1:26947807-27104265:+","gi|118150986|ref|NP_001071409.1|",1341,{"v":4e-180,"d":"4.00E-180"},"E3 ubiquitin-protein ligase MARCH3 [Bos taurus]","gi|118150985|ref|NM_001077941.1|",1835,0,"Bos taurus membrane associated ring-CH-type finger 3 (MARCH3), mRNA","A0JN69",521,0,"E3 ubiquitin-protein ligase MARCH3","ECU06g0830",62.4,{"v":3e-09,"d":"3.00E-09"},"COG5183","pfam12906","RINGv","RING-variant domain.","GO:0006897|endocytosis;GO:0016567|protein ubiquitination;","GO:0030659|cytoplasmic vesicle membrane;GO:0031901|early endosome membrane;GO:0005768|endosome;GO:0016021|integral component of membrane;GO:0005764|lysosome;","GO:0016740|transferase activity;GO:0008270|zinc ion binding;","K10658","MARCH3; E3 ubiquitin-protein ligase MARCH3 [EC:2.3.2.27]"]
["gene9809",0,32,0,10.4869657346109,0,0,0,0,"Inf","Inf",0.000461290363816588,0.00994047957283167,"up","yes","FAM170A","protein_coding","chrNC_037334.1:32734451-32787206:-","gi|296485591|tpg|DAA27706.1|",1557,0,"TPA: hypothetical protein BOS_7852 [Bos taurus]","gi|982985055|ref|XM_015464204.1|",1327,0,"PREDICTED: Bos taurus family with sequence similarity 170, member A (FAM170A), mRNA","Q66LM6",153,{"v":5e-40,"d":"5.00E-40"},"Protein FAM170A",".",".",".",".","pfam12756","zf-C2H2_2","C2H2 type zinc-finger (2 copies). This family contains two copies of a C2H2-like zinc finger domain.","GO:0045893|positive regulation of transcription, DNA-templated;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["gene9846",39,380,127,173.701471803346,23,36,25,30.8325407692034,5.63370606086557,2.49408429292935,{"v":1.71921707627771e-09,"d":"1.72E-09"},{"v":2.14196429708644e-07,"d":"2.14E-07"},"up","yes","UNC5A","protein_coding","chrNC_037334.1:38268514-38332964:+","gi|528956161|ref|XP_005209218.1|",4442,0,"PREDICTED: netrin receptor UNC5A isoform X1 [Bos taurus]","gi|982985082|ref|XM_005199023.3|",3857,0,"PREDICTED: Bos taurus unc-5 netrin receptor A (UNC5A), transcript variant X1, mRNA","Q8K1S4",1674,0,"Netrin receptor UNC5A",".",".",".",".","pfam00791","ZU5","ZU5 domain. Domain present in ZO-1 and Unc5-like netrin receptors Domain of unknown function.","GO:0033564|anterior/posterior axon guidance;GO:0006915|apoptotic process;GO:0007411|axon guidance;GO:0038007|netrin-activated signaling pathway;GO:0031175|neuron projection development;","GO:0005829|cytosol;GO:0016021|integral component of membrane;GO:0031226|intrinsic component of plasma membrane;GO:0045121|membrane raft;GO:0032589|neuron projection membrane;GO:0032809|neuronal cell body membrane;GO:0005886|plasma membrane;","GO:0005042|netrin receptor activity;","K07521","UNC5; netrin receptor unc-5"]
["gene9878",3697,23611,33165,18886.955208943,3498,4144,4136,4321.22113200159,4.37074489640722,2.12787917601229,{"v":6.03536129689599e-13,"d":"6.04E-13"},{"v":1.53745440322982e-10,"d":"1.54E-10"},"up","yes","PDLIM7","protein_coding","chrNC_037334.1:38975500-38995645:-","gi|741933167|ref|XP_010805460.1|",1925,0,"PREDICTED: PDZ and LIM domain protein 7 isoform X2 [Bos taurus]","gi|741933166|ref|XM_010807158.1|",1955,0,"PREDICTED: Bos taurus PDZ and LIM domain 7 (PDLIM7), transcript variant X2, mRNA","Q3SX40",617,0,"PDZ and LIM domain protein 7",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0001503|ossification;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0046872|metal ion binding;",".","."]
["rna78872",35461,14404,9930,17012.1238744691,4929,6487,5093,6061.38619744818,2.80663916145635,1.48884359415307,{"v":3.92890078956057e-07,"d":"3.93E-07"},{"v":2.72738366002318e-05,"d":"2.73E-05"},"up","yes","rna78872","protein_coding","chrNC_006853.1:3024-3098:+",".",".",".",".","gi|971456312|emb|LN873135.1|",75,{"v":3e-30,"d":"3.00E-30"},"Tragelaphus imberbis mitochondrial complete genome",".",".",".",".",".",".",".",".","pfam06656","Tenui_PVC2","Tenuivirus PVC2 protein. This family consists of several Tenuivirus PVC2 proteins from Rice grassy stunt virus, Maize stripe virus and Rice hoja blanca virus. The function of this family is unknown.",".",".",".",".","."]

{"sheet":"down-regulated mRNA","index":1,"n_rows":477,"n_cols":42,"rows_kept":477,"flags":["formulas_cached_only"]}
["Gene","L1_count","L2_count","L3_count","L_normalize","B1_count","B2_count","B3_count","B_normalize","FoldChange","Log2FoldChange","pval","padj","Up/Down","Significant","GeneName","Biotype","Position","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["gene10081",104,35,52,54.545260350818,132,115,158,148.574674713803,0.367123538758457,-1.44566247660519,0.00255968276772039,0.0367725624601361,"down","yes","ARHGAP45","protein_coding","chrNC_037334.1:43563225-43576149:+","gi|594052482|ref|XP_006050554.1|",4661,0,"PREDICTED: minor histocompatibility protein HA-1 isoform X5 [Bubalus bubalis]","gi|594052481|ref|XM_006050492.1|",4753,0,"PREDICTED: Bubalus bubalis histocompatibility (minor) HA-1 (HMHA1), transcript variant X5, mRNA","Q5RB40",1418,0,"Rho GTPase-activating protein 45",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0035556|intracellular signal transduction;","GO:0005737|cytoplasm;GO:0032587|ruffle membrane;","GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;",".","."]
["gene10186",70,145,161,115.209273074395,289,231,242,280.148545505678,0.411243516779422,-1.28193515983012,0.000931932234643382,0.01709900873737,"down","yes","LOC104969184","protein_coding","chrNC_037334.1:49328956-49335502:+","gi|982932028|ref|XP_015327718.1|",1252,{"v":2e-167,"d":"2.00E-167"},"PREDICTED: palladin-like [Bos taurus]","gi|982985382|ref|XM_015464291.1|",1715,0,"PREDICTED: Bos taurus palladin-like (LOC104969184), transcript variant X3, mRNA","Q8WX93",139,{"v":5e-33,"d":"5.00E-33"},"Palladin",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0030036|actin cytoskeleton organization;GO:0016477|cell migration;GO:0007010|cytoskeleton organization;GO:0003382|epithelial cell morphogenesis;GO:0003334|keratinocyte development;","GO:0015629|actin cytoskeleton;GO:0005884|actin filament;GO:0005829|cytosol;GO:0005925|focal adhesion;GO:0030426|growth cone;GO:0030027|lamellipodium;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0002102|podosome;GO:0001726|ruffle;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0051371|muscle alpha-actinin binding;",".","."]
["gene10234",91,41,27,45.4454235069842,154,96,137,142.244378229553,0.319488362722108,-1.64616471253784,0.000996487360543063,0.018039835586075,"down","yes","TMEM173","protein_coding","chrNC_037334.1:50732084-50743011:-","gi|114052260|ref|NP_001039822.1|",1850,0,"stimulator of interferon genes protein [Bos taurus]","gi|402744324|ref|NM_001046357.2|",2514,0,"Bos taurus transmembrane protein 173 (TMEM173), mRNA","Q2KI99",717,0,"Stimulator of interferon genes protein",".",".",".",".","pfam15009","TMEM173","Transmembrane protein 173. Transmembrane protein 173, also known as stimulator of interferon genes protein (STING), is a transmembrane adaptor protein which is involved in innate immune signalling processes. It induces expression of type I interferons (IFN-alpha and IFN-beta) via the NF-kappa-B and IRF3, pathways in response to non-self cytosolic RNA and dsDNA.","GO:0002218|activation of innate immune response;GO:0006915|apoptotic process;GO:0071360|cellular response to exogenous dsRNA;GO:0035458|cellular response to interferon-beta;GO:0051607|defense response to virus;GO:0045087|innate immune response;GO:0032608|interferon-beta production;GO:0002230|positive regulation of defense response to virus by host;GO:0051091|positive regulation of sequence-specific DNA binding transcription factor activity;GO:0032092|positive regulation of protein binding;GO:0033160|positive regulation of protein import into nucleus, translocation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0032481|positive regulation of type I interferon production;","GO:0005737|cytoplasm;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0005741|mitochondrial outer membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005777|peroxisome;GO:0005886|plasma membrane;","GO:0035438|cyclic-di-GMP binding;GO:0061507|cyclic-GMP-AMP binding;GO:0042803|protein homodimerization activity;GO:0019901|protein kinase binding;GO:0008134|transcription factor binding;GO:0031625|ubiquitin protein ligase binding;","K12654","TMEM173, MITA; transmembrane protein 173"]
["gene10251",198,446,726,420.735791819192,6416,1358,4496,4519.39929179966,0.0930955121807021,-3.42514456775543,{"v":2.04229666782932e-05,"d":"2.04E-05"},0.000775882373233534,"down","yes","HBEGF","protein_coding","chrNC_037334.1:51533600-51544783:-","gi|221136878|ref|NP_001137562.1|",898,{"v":3e-115,"d":"3.00E-115"},"proheparin-binding EGF-like growth factor precursor [Bos taurus]","gi|221136877|ref|NM_001144090.1|",1602,0,"Bos taurus heparin binding EGF like growth factor (HBEGF), mRNA","Q01580",313,{"v":3e-102,"d":"3.00E-102"},"Proheparin-binding EGF-like growth factor",".",".",".",".","pfam00008","EGF","EGF-like domain. There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.","GO:0060326|cell chemotaxis;GO:0007173|epidermal growth factor receptor signaling pathway;GO:0008284|positive regulation of cell proliferation;GO:0051549|positive regulation of keratinocyte migration;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0051897|positive regulation of protein kinase B signaling;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0090303|positive regulation of wound healing;GO:0008016|regulation of heart contraction;GO:0035313|wound healing, spreading of epidermal cells;","GO:0009986|cell surface;GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0005154|epidermal growth factor receptor binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;","K08523","HBEGF; heparin-binding EGF-like growth factor"]
["gene10312",3952,3875,6676,4350.23306486994,19268,9428,17413,16947.3432687511,0.256691151874598,-1.96189452771046,{"v":1.20099162835654e-05,"d":"1.20E-05"},0.000501690953860035,"down","yes","DIAPH1","protein_coding","chrNC_037334.1:52600824-52714372:-","gi|942099332|ref|XP_014338699.1|",2899,0,"PREDICTED: protein diaphanous homolog 1 [Bos mutus]","gi|982985483|ref|XM_015464316.1|",3257,0,"PREDICTED: Bos taurus diaphanous related formin 1 (DIAPH1), mRNA","O60610",1078,0,"Protein diaphanous homolog 1",".",".",".",".","pfam02181","FH2","Formin Homology 2 Domain.","GO:0030041|actin filament polymerization;GO:0071420|cellular response to histamine;GO:0007010|cytoskeleton organization;GO:0043312|neutrophil degranulation;GO:0030335|positive regulation of cell migration;GO:0035372|protein localization to microtubule;GO:2000145|regulation of cell motility;GO:0008360|regulation of cell shape;GO:0051493|regulation of cytoskeleton organization;GO:0032886|regulation of microtubule-based process;GO:0051279|regulation of release of sequestered calcium ion into cytosol;GO:0007605|sensory perception of sound;","GO:0005829|cytosol;GO:0005815|microtubule organizing center;GO:0072686|mitotic spindle;GO:0005886|plasma membrane;GO:0032587|ruffle membrane;GO:0030667|secretory granule membrane;","GO:0003779|actin binding;GO:0044325|ion channel binding;GO:0017048|Rho GTPase binding;GO:0003723|RNA binding;GO:0005102|receptor binding;","K05740","DIAPH1; diaphanous 1"]
["gene10330",130,83,80,85.6513188515027,363,200,324,326.030546393852,0.262709490870938,-1.9284597734219,{"v":4.32615379428379e-05,"d":"4.33E-05"},0.00142036241547423,"down","yes","LOC100847454","protein_coding","chrNC_037334.1:53311900-53697001:+","gi|741881011|ref|XP_010796790.1|",1095,{"v":1e-140,"d":"1.00E-140"},"PREDICTED: uncharacterized protein LOC100847454 isoform X1 [Bos taurus]","gi|982985495|ref|XR_801448.2|",2447,0,"PREDICTED: Bos taurus uncharacterized LOC100847454 (LOC100847454), transcript variant X3, misc_RNA",".",".",".",".",".",".",".",".","pfam04598","Gasdermin","Gasdermin family. The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein",".",".",".",".","."]
["gene1034",922,678,370,576.122215300054,1107,1016,1097,1182.60790456115,0.487162493230455,-1.03752503084133,0.000553398664367571,0.0114082494892133,"down","yes","PCOLCE2","protein_coding","chrNC_037328.1:126132532-126231894:+","gi|742195100|ref|XP_010856445.1|",2092,0,"PREDICTED: procollagen C-endopeptidase enhancer 2 [Bison bison bison]","gi|115497327|ref|NM_001075629.1|",1906,0,"Bos taurus procollagen C-endopeptidase enhancer 2 (PCOLCE2), mRNA","Q9UKZ9",734,0,"Procollagen C-endopeptidase enhancer 2",".",".",".",".","pfam00431","CUB","CUB domain.","GO:1990830|cellular response to leukemia inhibitory factor;","GO:0005576|extracellular region;","GO:0005518|collagen binding;GO:0008201|heparin binding;GO:0016504|peptidase activator activity;",".","."]
["gene1035",312,111,121,154.85282995141,418,253,356,377.589264940965,0.410109196233692,-1.28592000005912,0.00360050065975529,0.0472752317565198,"down","yes","TRPC1","protein_coding","chrNC_037328.1:126257858-126320522:-","gi|528937692|ref|XP_005201902.1|",4094,0,"PREDICTED: short transient receptor potential channel 1 isoform X1 [Bos taurus]","gi|982911784|ref|XM_005201845.3|",4148,0,"PREDICTED: Bos taurus transient receptor potential cation channel, subfamily C, member 1 (TRPC1), transcript variant X1, mRNA","P48995",1518,0,"Short transient receptor potential channel 1",".",".",".",".","pfam08344","TRP_2","Transient receptor ion channel II. This domain is found in the transient receptor ion channel (Trp) family of proteins. There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors. This domain does not tend to appear with the TRP domain (pfam06011) but is often found to the C-terminus of Ankyrin repeats (pfam00023).","GO:0070588|calcium ion transmembrane transport;GO:0006816|calcium ion transport;GO:0006828|manganese ion transport;GO:0042438|melanin biosynthetic process;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:1903779|regulation of cardiac conduction;GO:0051480|cytosolic calcium ion homeostasis;GO:0051592|response to calcium ion;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0043235|receptor complex;","GO:0005262|calcium channel activity;GO:0005261|cation channel activity;GO:0070679|inositol 1,4,5 trisphosphate binding;GO:0044325|ion channel binding;GO:0015279|store-operated calcium channel activity;","K04964","TRPC1; transient receptor potential cation channel subfamily C member 1"]
["gene10365",13,5,81,29.9035427971599,1300,358,927,951.901934534725,0.0314145204587448,-4.99242463219814,0.00181266624824597,0.0286680602709012,"down","yes","STK32A","protein_coding","chrNC_037334.1:58457688-58590680:+","gi|528957153|ref|XP_005209598.1|",2015,0,"PREDICTED: serine/threonine-protein kinase 32A isoform X1 [Bos taurus]","gi|742166545|ref|XM_010850474.1|",2353,0,"PREDICTED: Bison bison bison serine/threonine kinase 32A (STK32A), mRNA","Q8BGW6",719,0,"Serine/threonine-protein kinase 32A",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0018105|peptidyl-serine phosphorylation;","GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004674|protein serine/threonine kinase activity;","K08793","STK32, YANK; serine/threonine kinase 32 [EC:2.7.11.1]"]
["gene10367",2558,1303,4269,2404.7926297062,8987,4743,7223,7706.98303950625,0.312027756825096,-1.68025372332306,0.00205523689776268,0.0314750208964396,"down","yes","DPYSL3","protein_coding","chrNC_037334.1:58594477-58710806:-","gi|528957212|ref|XP_005209627.1|",2984,0,"PREDICTED: dihydropyrimidinase-related protein 3 isoform X1 [Bos taurus]","gi|982932300|ref|XM_005209570.3|",4018,0,"PREDICTED: Bos taurus dihydropyrimidinase like 3 (DPYSL3), transcript variant X1, mRNA","Q14195",1135,0,"Dihydropyrimidinase-related protein 3","PA0441",422,{"v":1e-132,"d":"1.00E-132"},"COG0044","pfam01979","Amidohydro_1","Amidohydrolase family. This family of enzymes are a a large metal dependent hydrolase superfamily. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit. Dihydroorotases (EC:3.5.2.3) are also included.","GO:0051764|actin crosslink formation;GO:0051017|actin filament bundle assembly;GO:0071345|cellular response to cytokine stimulus;GO:0030336|negative regulation of cell migration;GO:0010977|negative regulation of neuron projection development;GO:0048666|neuron development;GO:0051491|positive regulation of filopodium assembly;GO:0010976|positive regulation of neuron projection development;GO:0051260|protein homooligomerization;GO:0048678|response to axon injury;","GO:0044297|cell body;GO:0005829|cytosol;GO:0070382|exocytic vesicle;GO:0005615|extracellular space;GO:0031941|filamentous actin;GO:0030426|growth cone;GO:0030027|lamellipodium;","GO:0035374|chondroitin sulfate binding;GO:0031005|filamin binding;GO:0016810|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds;GO:0017124|SH3 domain binding;",".","."]
["gene10443",1108,2169,1407,1431.71033110022,3980,2518,3555,3694.93031610253,0.387479656885765,-1.36780752561128,0.000435487459427221,0.00948909944884477,"down","yes","GPX3","protein_coding","chrNC_037334.1:62284773-62292970:+","gi|742166995|ref|XP_010848894.1|",1114,{"v":1e-147,"d":"1.00E-147"},"PREDICTED: LOW QUALITY PROTEIN: glutathione peroxidase 3 [Bison bison bison]","gi|156602650|ref|NM_174077.3|",1562,0,"Bos taurus glutathione peroxidase 3 (GPX3), mRNA","P37141",433,{"v":5e-149,"d":"5.00E-149"},"Glutathione peroxidase 3","STM1341",102,{"v":3e-24,"d":"3.00E-24"},"COG0386","pfam00255","GSHPx","Glutathione peroxidase.","GO:0051289|protein homotetramerization;GO:0006979|response to oxidative stress;","GO:0005615|extracellular space;","GO:0004602|glutathione peroxidase activity;GO:0008430|selenium binding;","K00432","E1.11.1.9; glutathione peroxidase [EC:1.11.1.9]"]
["gene10464",9,15,1,7.56849595323288,234,45,162,162.453781637213,0.0465886104771301,-4.42387888761013,0.000152055702705912,0.0041199442107335,"down","yes","GRIA1","protein_coding","chrNC_037334.1:64771811-65120623:+","gi|985482170|ref|NP_001306365.1|",4649,0,"glutamate receptor 1 precursor [Macaca fascicularis]","gi|982932475|ref|XM_002689318.5|",5672,0,"PREDICTED: Bos taurus glutamate receptor, ionotropic, AMPA 1 (GRIA1), transcript variant X1, mRNA","Q38PU8",1793,0,"Glutamate receptor 1",".",".",".",".","pfam00060","Lig_chan","Ligand-gated ion channel. This family includes the four transmembrane regions of the ionotropic glutamate receptors and NMDA receptors.",".","GO:0032281|AMPA glutamate receptor complex;GO:0030054|cell junction;GO:0030425|dendrite;GO:0043197|dendritic spine;GO:0031901|early endosome membrane;GO:0005789|endoplasmic reticulum membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0055038|recycling endosome membrane;","GO:0004971|AMPA glutamate receptor activity;GO:0005234|extracellular-glutamate-gated ion channel activity;","K05197","GRIA1; glutamate receptor 1"]
["gene10495",18,4,2,6.61633224709438,71,42,53,61.0825753887052,0.108317833768315,-3.20665730280936,0.000722943064856826,0.0141372779872722,"down","yes","TIMD4","protein_coding","chrNC_037334.1:68286089-68314227:-","gi|296485126|tpg|DAA27241.1|",1333,0,"TPA: T-cell immunoglobulin and mucin domain containing 4 [Bos taurus]","gi|116734828|ref|NM_001075320.1|",1115,0,"Bos taurus T-cell immunoglobulin and mucin domain containing 4 (TIMD4), mRNA","Q96H15",248,{"v":9e-77,"d":"9.00E-77"},"T-cell immunoglobulin and mucin domain-containing protein 4",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene10506",80,30,73,53.1012685764861,143,120,150,151.633278443158,0.350195347101143,-1.51376817947311,0.00153386831878727,0.0253550388199998,"down","yes","HAVCR2","protein_coding","chrNC_037334.1:68781847-68801885:-","gi|741934387|ref|XP_010805856.1|",1352,{"v":2e-171,"d":"2.00E-171"},"PREDICTED: hepatitis A virus cellular receptor 2 isoform X1 [Bos taurus]","gi|982932523|ref|XM_010807554.2|",4362,0,"PREDICTED: Bos taurus hepatitis A virus cellular receptor 2 (HAVCR2), transcript variant X1, mRNA","Q8TDQ0",230,{"v":1e-67,"d":"1.00E-67"},"Hepatitis A virus cellular receptor 2",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0002250|adaptive immune response;GO:0071222|cellular response to lipopolysaccharide;GO:0050830|defense response to Gram-positive bacterium;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0002281|macrophage activation involved in immune response;GO:0060135|maternal process involved in female pregnancy;GO:0002519|natural killer cell tolerance induction;GO:1900425|negative regulation of defense response to bacterium;GO:0010629|negative regulation of gene expression;GO:0071656|negative regulation of granulocyte colony-stimulating factor production;GO:2000521|negative regulation of immunological synapse formation;GO:0032687|negative regulation of interferon-alpha production;GO:0032689|negative regulation of interferon-gamma production;GO:0032703|negative regulation of interleukin-2 production;GO:0032712|negative regulation of interleukin-3 production;GO:0032715|negative regulation of interleukin-6 production;GO:0030886|negative regulation of myeloid dendritic cell activation;GO:0032815|negative regulation of natural killer cell activation;GO:0002859|negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:2001189|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0042130|negative regulation of T cell proliferation;GO:0002826|negative regulation of T-helper 1 type immune response;GO:0032720|negative regulation of tumor necrosis factor production;GO:0032722|positive regulation of chemokine production;GO:1900426|positive regulation of defense response to bacterium;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0032729|positive regulation of interferon-gamma production;GO:0032732|positive regulation of interleukin-1 production;GO:0032753|positive regulation of interleukin-4 production;GO:0043032|positive regulation of macrophage activation;GO:1901224|positive regulation of NIK/NF-kappaB signaling;GO:0042102|positive regulation of T cell proliferation;GO:1904469|positive regulation of tumor necrosis factor secretion;GO:0002652|regulation of tolerance induction dependent upon immune response;GO:0034138|toll-like receptor 3 signaling pathway;GO:0034154|toll-like receptor 7 signaling pathway;GO:0034162|toll-like receptor 9 signaling pathway;","GO:0030054|cell junction;GO:0009986|cell surface;GO:0005769|early endosome;GO:0001772|immunological synapse;GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;",".","."]
["gene10510",264,90,117,134.232356785501,633,971,774,872.333146238591,0.153877400353634,-2.70014673321402,{"v":4.61397282043708e-10,"d":"4.61E-10"},{"v":6.78563188349951e-08,"d":"6.79E-08"},"down","yes","CYFIP2","protein_coding","chrNC_037334.1:68943163-69076708:+","gi|329663482|ref|NP_001192779.1|",6666,0,"cytoplasmic FMR1-interacting protein 2 [Bos taurus]","gi|742184196|ref|XM_010855283.1|",5986,0,"PREDICTED: Bison bison bison cytoplasmic FMR1 interacting protein 2 (CYFIP2), transcript variant X1, mRNA","Q5SQX6",2571,0,"Cytoplasmic FMR1-interacting protein 2",".",".",".",".","pfam05994","FragX_IP","Cytoplasmic Fragile-X interacting family. CYFIP1/2 (Cytoplasmic fragile X mental retardation interacting protein) like proteins for a highly conserved protein family. The function of CYFIPs is unclear, but CYFIP interaction with fragile X mental retardation interacting protein (FMRP) involves the domain of FMRP which also mediating homo- and heteromerization.","GO:0097202|activation of cysteine-type endopeptidase activity;GO:0006915|apoptotic process;GO:0098609|cell-cell adhesion;GO:0097484|dendrite extension;GO:0031175|neuron projection development;GO:0051388|positive regulation of neurotrophin TRK receptor signaling pathway;GO:0045862|positive regulation of proteolysis;","GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0043005|neuron projection;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0045202|synapse;",".","K05749","CYFIP; cytoplasmic FMR1 interacting protein"]
["gene10599",1352,1599,1625,1375.45583986706,3452,1890,2723,2966.78312796645,0.46361859985696,-1.10898964807896,0.00353637956694938,0.0466599481810746,"down","yes","SSBP2","protein_coding","chrNC_037334.1:81397201-81711747:-","gi|355750042|gb|EHH54380.1|",1307,{"v":2e-160,"d":"2.00E-160"},"hypothetical protein EGM_15204 [Macaca fascicularis]","gi|982932622|ref|XM_005209711.3|",6057,0,"PREDICTED: Bos taurus single-stranded DNA binding protein 2 (SSBP2), transcript variant X1, mRNA","P81877",483,{"v":2e-153,"d":"2.00E-153"},"Single-stranded DNA-binding protein 2",".",".",".",".","pfam04503","SSDP","Single-stranded DNA binding protein, SSDP. This is a family of eukaryotic single-stranded DNA binding proteins with specificity to a pyrimidine-rich element found in the promoter region of the alpha2(I) collagen gene.","GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006355|regulation of transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0003697|single-stranded DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;",".","."]
["gene10613",13,8,13,10.0024247494288,101,8,77,68.4813900714885,0.146060480650102,-2.77536221163002,0.00224698623370206,0.0335100334866157,"down","yes","EDIL3","protein_coding","chrNC_037334.1:83843439-84324056:-","gi|358413303|ref|XP_618255.4|",2605,0,"PREDICTED: EGF-like repeat and discoidin I-like domain-containing protein 3 isoform X1 [Bos taurus]","gi|982985732|ref|XM_618255.8|",4920,0,"PREDICTED: Bos taurus EGF like repeats and discoidin domains 3 (EDIL3), transcript variant X1, mRNA","O43854",981,0,"EGF-like repeat and discoidin I-like domain-containing protein 3",".",".",".",".","pfam00754","F5_F8_type_C","F5/8 type C domain. This domain is also known as the discoidin (DS) domain family.","GO:0007155|cell adhesion;GO:0007275|multicellular organismal development;GO:0010811|positive regulation of cell-substrate adhesion;","GO:0070062|extracellular exosome;GO:1903561|extracellular vesicle;","GO:0005509|calcium ion binding;GO:0005178|integrin binding;",".","."]
["gene10677",2019,3383,3113,2590.93686935023,5680,7247,6016,6954.17456165135,0.372572883579583,-1.42440541832348,{"v":3.31643901563245e-06,"d":"3.32E-06"},0.000166586833723608,"down","yes","RHOBTB3","protein_coding","chrNC_037334.1:95035880-95121101:+","gi|297477546|ref|XP_002689442.1|",3228,0,"PREDICTED: rho-related BTB domain-containing protein 3 isoform X1 [Bos taurus]","gi|982985779|ref|XM_015464384.1|",5236,0,"PREDICTED: Bos taurus Rho-related BTB domain containing 3 (RHOBTB3), transcript variant X1, mRNA","O94955",1212,0,"Rho-related BTB domain-containing protein 3",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0008584|male gonad development;GO:0042147|retrograde transport, endosome to Golgi;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0032588|trans-Golgi network membrane;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0003924|GTPase activity;GO:0017137|Rab GTPase binding;","K07869","RHOBTB3; Rho-related BTB domain-containing protein 3"]
["gene10774",5,0,3,2.22448108500536,356,2,191,202.741236938367,0.0109720208803974,-6.51002691694025,{"v":2.16705182767846e-09,"d":"2.17E-09"},{"v":2.61983710574128e-07,"d":"2.62E-07"},"down","yes","LOC112447864","pseudogene","chrNC_037335.1:577889-711876:-","gi|982985870|ref|XP_015319896.1|",3013,0,"PREDICTED: LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX60 [Bos taurus]","gi|982985869|ref|XM_015464410.1|",2388,0,"PREDICTED: Bos taurus DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 (DDX60), mRNA","Q8IY21",712,0,"Probable ATP-dependent RNA helicase DDX60","SPAC694.02",178,{"v":4e-69,"d":"4.00E-69"},"COG4581","pfam00271","Helicase_C","Helicase conserved C-terminal domain. The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.","GO:0051607|defense response to virus;GO:0045087|innate immune response;GO:1900245|positive regulation of MDA-5 signaling pathway;GO:1900246|positive regulation of RIG-I signaling pathway;GO:0009615|response to virus;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0045111|intermediate filament cytoskeleton;","GO:0005524|ATP binding;GO:0003690|double-stranded DNA binding;GO:0003725|double-stranded RNA binding;GO:0004386|helicase activity;GO:0003727|single-stranded RNA binding;",".","."]
["gene10937",2,4,11,5.21045516018791,40,34,38,41.1452707142597,0.126635578518192,-2.98124530512429,0.000742752719268375,0.0143963843977215,"down","yes","CDKN2B","protein_coding","chrNC_037335.1:22082124-22087035:+","gi|803314547|ref|XP_012015589.1|",578,{"v":2e-66,"d":"2.00E-66"},"PREDICTED: cyclin-dependent kinase 4 inhibitor B [Ovis aries musimon]","gi|115497499|ref|NM_001075894.1|",2641,0,"Bos taurus cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), mRNA","Q2KJD8",226,{"v":2e-67,"d":"2.00E-67"},"Cyclin-dependent kinase 4 inhibitor B",".",".",".",".","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0007050|cell cycle arrest;GO:0031668|cellular response to extracellular stimulus;GO:0031670|cellular response to nutrient;GO:0000086|G2/M transition of mitotic cell cycle;GO:0030219|megakaryocyte differentiation;GO:0007093|mitotic cell cycle checkpoint;GO:0008285|negative regulation of cell proliferation;GO:0050680|negative regulation of epithelial cell proliferation;GO:0042326|negative regulation of phosphorylation;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0004861|cyclin-dependent protein serine/threonine kinase inhibitor activity;GO:0019901|protein kinase binding;","K04685","CDKN2B, P15, INK4B; cyclin-dependent kinase inhibitor 2B"]
["gene10939",212,102,208,152.560629278834,519,488,572,579.552064668058,0.26323886770417,-1.92555557350371,{"v":9.97228153116744e-08,"d":"9.97E-08"},{"v":8.39289570400408e-06,"d":"8.39E-06"},"down","yes","MTAP","protein_coding","chrNC_037335.1:22190188-22236828:-","gi|297477694|ref|XP_002689552.1|",1522,0,"PREDICTED: S-methyl-5'-thioadenosine phosphorylase [Bos taurus]","gi|982985997|ref|XM_015464438.1|",2165,0,"PREDICTED: Bos taurus methylthioadenosine phosphorylase (MTAP), mRNA","Q3MHF7",590,0,"S-methyl-5'-thioadenosine phosphorylase","PAB2264",251,{"v":2e-76,"d":"2.00E-76"},"COG0005","pfam01048","PNP_UDP_1","Phosphorylase superfamily. Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)","GO:0019509|L-methionine biosynthetic process from methylthioadenosine;GO:0006166|purine ribonucleoside salvage;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0017061|S-methyl-5-thioadenosine phosphorylase activity;","K00772","E2.4.2.28, mtaP; 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]"]
["gene11038",529,619,921,623.585960268298,4773,5150,4742,5385.71451179336,0.115785186701374,-3.11047740494096,{"v":2.47841179011409e-18,"d":"2.48E-18"},{"v":1.4142313356749e-15,"d":"1.41E-15"},"down","yes","PLIN2","protein_coding","chrNC_037335.1:25117110-25131174:+","gi|296484843|tpg|DAA26958.1|",2373,0,"TPA: perilipin-2 [Bos taurus]","gi|31343121|ref|NM_173980.2|",1782,0,"Bos taurus perilipin 2 (PLIN2), mRNA","Q9TUM6",916,0,"Perilipin-2",".",".",".",".","pfam03036","Perilipin","Perilipin family. The perilipin family includes lipid droplet-associated protein (perilipin) and adipose differentiation-related protein (adipophilin).",".","GO:0005811|lipid particle;GO:0016020|membrane;",".","K17284","PLIN2, ADRP; perilipin-2"]
["gene11044",20,16,13,14.448528840935,58,85,66,76.69670323274,0.188385266014501,-2.40824196156645,0.000313098072983909,0.00725081259764928,"down","yes","SH3GL2","protein_coding","chrNC_037335.1:26598503-26825714:-","gi|116003905|ref|NP_001070308.1|",1857,0,"endophilin-A1 [Bos taurus]","gi|402693109|ref|NM_001076840.2|",2555,0,"Bos taurus SH3-domain GRB2-like 2 (SH3GL2), mRNA","O35179",712,0,"Endophilin-A1",".",".",".",".","pfam03114","BAR","BAR domain. BAR domains are dimerization, lipid binding and curvature sensing modules found in many different protein families. A BAR domain with an additional N-terminal amphipathic helix (an N-BAR) can drive membrane curvature. These N-BAR domains are found in amphiphysin, endophilin, BRAP and Nadrin. BAR domains are also frequently found alongside domains that determine lipid specificity, like pfam00169 and pfam00787 domains in beta centaurins and sorting nexins respectively.","GO:1990416|cellular response to brain-derived neurotrophic factor stimulus;GO:0097484|dendrite extension;GO:0060988|lipid tube assembly;GO:0031175|neuron projection development;GO:1903527|positive regulation of membrane tubulation;GO:2000369|regulation of clathrin-mediated endocytosis;GO:0002090|regulation of receptor internalization;GO:0016191|synaptic vesicle uncoating;","GO:0097441|basilar dendrite;GO:0005829|cytosol;GO:0005769|early endosome;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0098793|presynapse;GO:0045202|synapse;","GO:0008289|lipid binding;GO:0008022|protein C-terminus binding;GO:0042803|protein homodimerization activity;GO:0019901|protein kinase binding;","K11247","SH3GL; endophilin-A"]
["gene11063",717,356,1012,614.341447820509,971,1593,1239,1394.78542176327,0.440455885353222,-1.18293056420754,0.00367043432561207,0.0479273051460129,"down","yes","LOC101903205","protein_coding","chrNC_037335.1:29789121-29852648:-","gi|296484833|tpg|DAA26948.1|",912,{"v":6e-109,"d":"6.00E-109"},"TPA: low density lipoprotein receptor-related protein associated protein 1-like [Bos taurus]","gi|850477813|gb|CP011887.1|",2001,0,"Ovis canadensis canadensis isolate 43U chromosome 2 sequence","Q99068",260,{"v":1e-74,"d":"1.00E-74"},"Alpha-2-macroglobulin receptor-associated protein",".",".",".",".","pfam06401","Alpha-2-MRAP_C","Alpha-2-macroglobulin RAP, C-terminal domain. The alpha-2-macroglobulin receptor-associated protein (RAP) is a intracellular glycoprotein that binds to the 2-macroglobulin receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of all currently known ligands of these receptors. Two different studies have provided conflicted domain boundaries.","GO:1900222|negative regulation of beta-amyloid clearance;GO:0060548|negative regulation of cell death;GO:0032091|negative regulation of protein binding;GO:0002091|negative regulation of receptor internalization;GO:0010916|negative regulation of very-low-density lipoprotein particle clearance;GO:0048259|regulation of receptor-mediated endocytosis;GO:0045056|transcytosis;","GO:0009986|cell surface;GO:0005801|cis-Golgi network;GO:0005737|cytoplasm;GO:0005793|endoplasmic reticulum-Golgi intermediate compartment;GO:0005768|endosome;GO:0031904|endosome lumen;GO:0005576|extracellular region;GO:0005794|Golgi apparatus;GO:0005796|Golgi lumen;GO:0005886|plasma membrane;GO:0005791|rough endoplasmic reticulum;GO:0048237|rough endoplasmic reticulum lumen;GO:0031982|vesicle;","GO:0008201|heparin binding;GO:0035473|lipase binding;GO:0050750|low-density lipoprotein particle receptor binding;GO:0048019|receptor antagonist activity;GO:0070326|very-low-density lipoprotein particle receptor binding;",".","."]
["gene11099",313,88,171,162.9320282469,401,285,347,379.730053619405,0.429073302715731,-1.22070395664852,0.00154469566994253,0.0255044630550522,"down","yes","IL33","protein_coding","chrNC_037335.1:38472458-38601092:-","gi|115496972|ref|NP_001068765.1|",1457,0,"interleukin-33 [Bos taurus]","gi|115496971|ref|NM_001075297.1|",2385,0,"Bos taurus interleukin 33 (IL33), mRNA","O97863",338,{"v":2e-107,"d":"2.00E-107"},"Interleukin-33",".",".",".",".","pfam15095","IL33","Interleukin 33.","GO:0001819|positive regulation of cytokine production;GO:0050729|positive regulation of inflammatory response;GO:0006351|transcription, DNA-templated;GO:0042092|type 2 immune response;","GO:0005694|chromosome;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0030133|transport vesicle;","GO:0005125|cytokine activity;","K12967","IL33; interleukin 33"]
["gene11128",392,292,694,411.000284892142,1533,716,1122,1240.76116249441,0.331248508831363,-1.59401413483416,0.00317819956989014,0.0430566058540054,"down","yes","GLIS3","protein_coding","chrNC_037335.1:40193063-40697965:+","gi|742205748|ref|XP_010859005.1|",4062,0,"PREDICTED: zinc finger protein GLIS3 isoform X1 [Bison bison bison]","gi|982986214|ref|XM_015464501.1|",6617,0,"PREDICTED: Bos taurus GLIS family zinc finger 3 (GLIS3), mRNA","Q8NEA6",1101,0,"Zinc finger protein GLIS3",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09232","GLIS1_3; zinc finger protein GLIS1/3"]
["gene11151",483,195,211,254.588635528485,656,605,714,724.953988755512,0.351179025810345,-1.50972141249417,{"v":1.43068943287913e-05,"d":"1.43E-05"},0.000578992910772687,"down","yes","DOCK8","protein_coding","chrNC_037335.1:44031671-44271335:-","gi|296484790|tpg|DAA26905.1|",10569,0,"TPA: dedicator of cytokinesis 8 [Bos taurus]","gi|982933332|ref|XM_010807850.2|",7823,0,"PREDICTED: Bos taurus dedicator of cytokinesis 8 (DOCK8), transcript variant X1, mRNA","Q8NF50",3806,0,"Dedicator of cytokinesis protein 8",".",".",".",".","pfam06920","Ded_cyto","Dedicator of cytokinesis. This family represents a conserved region approximately 200 residues long within a number of eukaryotic dedicator of cytokinesis proteins. These are potential guanine nucleotide exchange factors, which activate some small GTPases by exchanging bound GDP for free GTP.","GO:0007596|blood coagulation;GO:1990869|cellular response to chemokine;GO:0036336|dendritic cell migration;GO:0001771|immunological synapse formation;GO:0061485|memory T cell proliferation;GO:0070233|negative regulation of T cell apoptotic process;GO:1903905|positive regulation of establishment of T cell polarity;GO:0043547|positive regulation of GTPase activity;GO:2000406|positive regulation of T cell migration;GO:0007264|small GTPase mediated signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0031258|lamellipodium membrane;GO:0031256|leading edge membrane;GO:0016020|membrane;","GO:0005085|guanyl-nucleotide exchange factor activity;",".","."]
["gene11170",159,101,183,130.741839207106,351,241,281,321.069985436711,0.407206668755643,-1.29616690650441,0.000612480735993445,0.0124286542522254,"down","yes","MAMDC2","protein_coding","chrNC_037335.1:46233986-46397339:+","gi|594116002|ref|XP_006080676.1|",2926,0,"PREDICTED: MAM domain-containing protein 2 isoform X2 [Bubalus bubalis]","gi|982986287|ref|XR_001496931.1|",3368,0,"PREDICTED: Bos taurus MAM domain containing 2 (MAMDC2), transcript variant X2, misc_RNA","Q7Z304",965,0,"MAM domain-containing protein 2",".",".",".",".","pfam00629","MAM","MAM domain. An extracellular domain found in many receptors.",".","GO:0005783|endoplasmic reticulum;GO:0005576|extracellular region;GO:0016020|membrane;",".",".","."]
["gene11275",0,1,0,0.327717679206592,13,47,37,35.4633977876773,0.00924101185026512,-6.75773345559258,{"v":2.69262871318141e-06,"d":"2.69E-06"},0.000138670378728843,"down","yes","MSMP","protein_coding","chrNC_037335.1:59920990-59922048:-","gi|297467393|ref|XP_002705049.1|",700,{"v":1e-91,"d":"1.00E-91"},"PREDICTED: prostate-associated microseminoprotein [Bos taurus]","gi|982986407|ref|XM_002705003.4|",523,0,"PREDICTED: Bos taurus microseminoprotein, prostate associated (MSMP), mRNA","Q1L6U9",250,{"v":5e-84,"d":"5.00E-84"},"Prostate-associated microseminoprotein",".",".",".",".","pfam05825","PSP94","Beta-microseminoprotein (PSP-94). This family consists of the mammalian specific protein beta-microseminoprotein. Prostatic secretory protein of 94 amino acids (PSP94), also called beta-microseminoprotein, is a small, nonglycosylated protein, rich in cysteine residues. It was first isolated as a major protein from human seminal plasma. The exact function of this protein is unknown.",".","GO:0005737|cytoplasm;GO:0005615|extracellular space;",".",".","."]
["gene11364",766,567,656,586.92511517359,1492,1246,1426,1529.67584045102,0.383692478924513,-1.38197760913522,{"v":3.96553618018175e-06,"d":"3.97E-06"},0.000192743974031969,"down","yes","ANP32B","protein_coding","chrNC_037335.1:63155268-63179623:+","gi|78045555|ref|NP_001030246.1|",759,{"v":1e-93,"d":"1.00E-93"},"acidic leucine-rich nuclear phosphoprotein 32 family member B [Bos taurus]","gi|594079708|ref|XM_006063454.1|",999,0,"PREDICTED: Bubalus bubalis acidic (leucine-rich) nuclear phosphoprotein 32 family, member B (ANP32B), transcript variant X1, mRNA","Q3SZC6",296,{"v":5e-95,"d":"5.00E-95"},"Acidic leucine-rich nuclear phosphoprotein 32 family member B",".",".",".",".","pfam14580","LRR_9","Leucine-rich repeat.","GO:0043486|histone exchange;GO:0006913|nucleocytoplasmic transport;GO:0006334|nucleosome assembly;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;","GO:0042393|histone binding;","K18647","ANP32B; acidic leucine-rich nuclear phosphoprotein 32 family member B"]
["gene11468",9,0,4,3.57409566595831,246,17,183,164.243777445245,0.0217609197837027,-5.52211665251816,{"v":2.4706527645176e-05,"d":"2.47E-05"},0.000902138221321933,"down","yes","NEFM","protein_coding","chrNC_037335.1:72181208-72186703:+","gi|829732323|ref|XP_012637563.1|",2113,0,"PREDICTED: neurofilament medium polypeptide [Microcebus murinus]","gi|154757422|gb|BC151624.1|",3302,0,"Bos taurus cDNA clone IMAGE:8110934, containing frame-shift errors","O77788",809,0,"Neurofilament medium polypeptide",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0061564|axon development;","GO:0005883|neurofilament;","GO:0005198|structural molecule activity;",".","."]
["gene11493",36,11,18,18.515520402322,90,146,139,137.394544684099,0.134761685370356,-2.89151771842212,{"v":8.96088168608726e-07,"d":"8.96E-07"},{"v":5.50997662469301e-05,"d":"5.51E-05"},"down","yes","ADRA1A","protein_coding","chrNC_037335.1:73958334-74071379:-","gi|742119188|ref|XP_010838454.1|",2322,0,"PREDICTED: alpha-1A adrenergic receptor isoform X3 [Bison bison bison]","gi|942076604|ref|XM_005903000.2|",2182,0,"PREDICTED: Bos mutus adrenoceptor alpha 1A (ADRA1A), mRNA","P18130",813,0,"Alpha-1A adrenergic receptor",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0071880|adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0007267|cell-cell signaling;GO:0001994|norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure;GO:0007200|phospholipase C-activating G-protein coupled receptor signaling pathway;GO:0007204|positive regulation of cytosolic calcium ion concentration;GO:0043410|positive regulation of MAPK cascade;GO:0045987|positive regulation of smooth muscle contraction;GO:0045907|positive regulation of vasoconstriction;GO:0055117|regulation of cardiac muscle contraction;","GO:0005901|caveola;GO:0005737|cytoplasm;GO:0005887|integral component of plasma membrane;GO:0031965|nuclear membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0004937|alpha1-adrenergic receptor activity;GO:0046982|protein heterodimerization activity;","K04135","ADRA1A; adrenergic receptor alpha-1A"]
["gene11586",5,33,15,16.7246241021201,58,96,81,86.1481598184225,0.194137914696856,-2.36484619423168,0.00105186019352458,0.0187566394884061,"down","yes","FBP1","protein_coding","chrNC_037335.1:81068093-81098919:-","gi|440899113|gb|ELR50477.1|",1732,0,"Fructose-1,6-bisphosphatase 1, partial [Bos mutus]","gi|402746848|ref|NM_001034447.2|",1253,0,"Bos taurus fructose-bisphosphatase 1 (FBP1), mRNA","Q3SZB7",651,0,"Fructose-1,6-bisphosphatase 1","YLR377c",283,{"v":2e-90,"d":"2.00E-90"},"COG0158","pfam00316","FBPase","Fructose-1-6-bisphosphatase.","GO:0035690|cellular response to drug;GO:0071286|cellular response to magnesium ion;GO:0016311|dephosphorylation;GO:0030388|fructose 1,6-bisphosphate metabolic process;GO:0006002|fructose 6-phosphate metabolic process;GO:0006000|fructose metabolic process;GO:0006094|gluconeogenesis;GO:0030308|negative regulation of cell growth;GO:0045820|negative regulation of glycolytic process;GO:0046580|negative regulation of Ras protein signal transduction;GO:0051289|protein homotetramerization;GO:0006111|regulation of gluconeogenesis;GO:0005986|sucrose biosynthetic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0016208|AMP binding;GO:0042132|fructose 1,6-bisphosphate 1-phosphatase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0048029|monosaccharide binding;GO:0001191|transcriptional repressor activity, RNA polymerase II transcription factor binding;","K03841","FBP, fbp; fructose-1,6-bisphosphatase I [EC:3.1.3.11]"]
["gene11756",619,295,614,446.575182002934,761,933,804,917.059120814255,0.486964440860062,-1.03811166727759,0.000643638465261902,0.0129412607839234,"down","yes","CTNNAL1","protein_coding","chrNC_037335.1:98544957-98601628:-","gi|296484391|tpg|DAA26506.1|",3458,0,"TPA: catenin (cadherin-associated protein), alpha-like 1 [Bos taurus]","gi|329112492|ref|NM_001191534.1|",3178,0,"Bos taurus catenin alpha-like 1 (CTNNAL1), mRNA","Q5RC06",1203,0,"Alpha-catulin",".",".",".",".","pfam01044","Vinculin","Vinculin family.","GO:0007155|cell adhesion;GO:0007266|Rho protein signal transduction;","GO:0005938|cell cortex;GO:0005856|cytoskeleton;","GO:0051015|actin filament binding;GO:0045296|cadherin binding;",".","."]
["gene11845",142,164,176,144.807606535649,304,224,303,305.205500071172,0.474459360994086,-1.07564357392788,0.00339323203042407,0.0452097134827979,"down","yes","TMEM268","protein_coding","chrNC_037335.1:103800600-103825494:+","gi|555978406|ref|XP_005901145.1|",1339,{"v":5e-176,"d":"5.00E-176"},"PREDICTED: transmembrane protein C9orf91 homolog [Bos mutus]","gi|126722945|ref|NM_001024561.2|",2341,0,"Bos taurus chromosome 8 open reading frame, human C9orf91 (C8H9orf91), mRNA","Q5EA48",516,{"v":4e-176,"d":"4.00E-176"},"Transmembrane protein 268",".",".",".",".","pfam14800","DUF4481","Domain of unknown function (DUF4481).",".","GO:0016021|integral component of membrane;",".",".","."]
["gene11881",0,1,1,0.634839312814693,1,49,28,28.4633998473584,0.0223037063814992,-5.48657271577744,0.000183838063849325,0.00472104752446904,"down","yes","C5","protein_coding","chrNC_037335.1:110338434-110435971:-","gi|262205546|ref|NP_001160088.1|",7810,0,"complement C5a anaphylatoxin precursor [Bos taurus]","gi|262205545|ref|NM_001166616.1|",4498,0,"Bos taurus complement component 5 (C5), mRNA","P01031",2501,0,"Complement C5","RSc3030",56.2,{"v":1e-06,"d":"1.00E-06"},"COG2373","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0000187|activation of MAPK activity;GO:0007166|cell surface receptor signaling pathway;GO:0006935|chemotaxis;GO:0006957|complement activation, alternative pathway;GO:0006958|complement activation, classical pathway;GO:0019835|cytolysis;GO:0007186|G-protein coupled receptor signaling pathway;GO:0001701|in utero embryonic development;GO:0006954|inflammatory response;GO:0010760|negative regulation of macrophage chemotaxis;GO:0045766|positive regulation of angiogenesis;GO:0090197|positive regulation of chemokine secretion;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:0030449|regulation of complement activation;","GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005579|membrane attack complex;","GO:0008009|chemokine activity;GO:0004866|endopeptidase inhibitor activity;GO:0005102|receptor binding;","K03994","C5; complement component 5"]
["gene12054",21,6,6,9.2821238504486,132,58,144,122.602762843059,0.0757089288626426,-3.72339273281052,{"v":1.36837658604432e-06,"d":"1.37E-06"},{"v":7.98387574160135e-05,"d":"7.98E-05"},"down","yes","SNAP91","protein_coding","chrNC_037336.1:23474439-23643970:-","gi|555983977|ref|XP_005903882.1|",2841,0,"PREDICTED: clathrin coat assembly protein AP180 isoform X1 [Bos mutus]","gi|942078739|ref|XM_005903820.2|",4072,0,"PREDICTED: Bos mutus synaptosomal-associated protein, 91kDa (SNAP91), transcript variant X1, mRNA","O60641",784,0,"Clathrin coat assembly protein AP180",".",".",".",".","pfam07651","ANTH","ANTH domain. AP180 is an endocytotic accessory proteins that has been implicated in the formation of clathrin-coated pits.  The domain is involved in phosphatidylinositol 4,5-bisphosphate binding and is a universal adaptor for nucleation of clathrin coats.","GO:0048268|clathrin coat assembly;GO:0015031|protein transport;GO:2000369|regulation of clathrin-mediated endocytosis;","GO:0005905|coated pit;GO:0030136|clathrin-coated vesicle;GO:0005886|plasma membrane;","GO:0005545|1-phosphatidylinositol binding;GO:0030276|clathrin binding;GO:0019901|protein kinase binding;",".","."]
["gene12062",38,44,230,94.9612366147295,6181,1397,4353,4394.25718274798,0.021610304692122,-5.53213677631332,0.000157241787890469,0.00422268842172665,"down","yes","RSPO3","protein_coding","chrNC_037336.1:24092390-24186517:-","gi|426234403|ref|XP_004011185.1|",1097,{"v":2e-141,"d":"2.00E-141"},"PREDICTED: R-spondin-3 [Ovis aries]","gi|115496773|ref|NM_001076034.1|",2199,0,"Bos taurus R-spondin 3 (RSPO3), mRNA","Q1RMU1",426,{"v":8e-143,"d":"8.00E-143"},"R-spondin-3",".",".",".",".","pfam00090","TSP_1","Thrombospondin type 1 domain.","GO:0001974|blood vessel remodeling;GO:2000052|positive regulation of non-canonical Wnt signaling pathway;GO:0002040|sprouting angiogenesis;GO:0016055|Wnt signaling pathway;","GO:0005576|extracellular region;","GO:0008201|heparin binding;",".","."]
["gene12094",645,67,498,343.005645803033,730,581,650,720.70286091244,0.475932127380171,-1.07117224924038,0.00324030434862446,0.0436905119898886,"down","yes","SMPDL3A","protein_coding","chrNC_037336.1:28453557-28470952:-","gi|78042502|ref|NP_001030191.1|",2262,0,"acid sphingomyelinase-like phosphodiesterase 3a precursor [Bos taurus]","gi|402693128|ref|NM_001035019.2|",1958,0,"Bos taurus sphingomyelin phosphodiesterase, acid-like 3A (SMPDL3A), mRNA","Q3ZC91",875,0,"Acid sphingomyelinase-like phosphodiesterase 3a",".",".",".",".","pfam00149","Metallophos","Calcineurin-like phosphoesterase. This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.","GO:0009143|nucleoside triphosphate catabolic process;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0008081|phosphoric diester hydrolase activity;GO:0008270|zinc ion binding;","K01128","SMPDL3; sphingomyelin phosphodiesterase acid-like 3 [EC:3.1.4.-]"]
["gene12096",5,2,1,2.26567317620234,41,16,24,29.8596421242892,0.0758774390788608,-3.7201852022559,0.000725693302044923,0.0141813394524957,"down","yes","FABP7","protein_coding","chrNC_037336.1:28476061-28479847:-","gi|118151440|ref|NP_001071630.1|",699,{"v":4e-90,"d":"4.00E-90"},"fatty acid-binding protein, brain [Bos taurus]","gi|402692712|ref|NM_001078162.2|",815,0,"Bos taurus fatty acid binding protein 7 (FABP7), mRNA","Q09139",273,{"v":1e-91,"d":"1.00E-91"},"Fatty acid-binding protein, brain",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0021846|cell proliferation in forebrain;GO:0022008|neurogenesis;GO:0060134|prepulse inhibition;","GO:0071944|cell periphery;GO:0042995|cell projection;GO:0005911|cell-cell junction;GO:0005737|cytoplasm;GO:0043025|neuronal cell body;","GO:0008289|lipid binding;","K08756","FABP7; fatty acid-binding protein 7, brain"]
["gene12103",1098,910,1387,1010.3651079386,4397,1816,3199,3464.65998798969,0.291620277730296,-1.77783705435896,{"v":3.51806685243813e-05,"d":"3.52E-05"},0.00119921105575761,"down","yes","HSF2","protein_coding","chrNC_037336.1:28763137-28802954:-","gi|555956041|ref|XP_005890174.1|",2554,0,"PREDICTED: heat shock factor protein 2 isoform X2 [Bos mutus]","gi|942039463|ref|XM_005890112.2|",2321,0,"PREDICTED: Bos mutus heat shock transcription factor 2 (HSF2), transcript variant X2, mRNA","Q03933",947,0,"Heat shock factor protein 2","SPAC2E12.02.02",149,{"v":8e-37,"d":"8.00E-37"},"COG5169","pfam06546","Vert_HS_TF","Vertebrate heat shock transcription factor. This family represents the C-terminal region of vertebrate heat shock transcription factors. Heat shock transcription factors regulate the expression of heat shock proteins - a set of proteins that protect the cell from damage caused by stress and aid the cell's recovery after the removal of stress. This C-terminal region is found with the N-terminal pfam00447, and may contain a three-stranded coiled-coil trimerization domain and a CE2 regulatory region, the latter of which is involved in sustained heat shock response.","GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0007283|spermatogenesis;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0042803|protein homodimerization activity;GO:0001162|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003713|transcription coactivator activity;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09415","HSF2; heat shock transcription factor 2"]
["gene12135",2848,3664,3990,3168.42787321881,6339,5385,6311,6623.64388171855,0.478351180981176,-1.06385793476233,0.000320058921364181,0.00737609134526772,"down","yes","VGLL2","protein_coding","chrNC_037336.1:33499510-33507296:-","gi|528960497|ref|XP_005210807.1|",846,{"v":5e-103,"d":"5.00E-103"},"PREDICTED: transcription cofactor vestigial-like protein 2 isoform X2 [Bos taurus]","gi|982934891|ref|XM_005210750.3|",2250,0,"PREDICTED: Bos taurus vestigial like family member 2 (VGLL2), transcript variant X3, mRNA","Q8N8G2",303,{"v":4e-94,"d":"4.00E-94"},"Transcription cofactor vestigial-like protein 2",".",".",".",".","pfam07545","Vg_Tdu","Vestigial/Tondu family. The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain. The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. This short conserved region is needed for interaction with Sd.","GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0007519|skeletal muscle tissue development;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0008022|protein C-terminus binding;GO:0003713|transcription coactivator activity;",".","."]
["gene12163",232,149,250,186.074933549809,909,397,710,741.740009668671,0.250862743177258,-1.99502986975431,{"v":2.10790231608927e-05,"d":"2.11E-05"},0.000795510065877552,"down","yes","HS3ST5","protein_coding","chrNC_037336.1:36081127-36374606:+","gi|115496290|ref|NP_001069683.1|",1741,0,"heparan sulfate glucosamine 3-O-sulfotransferase 5 [Bos taurus]","gi|982934906|ref|XM_015472805.1|",2227,0,"PREDICTED: Bos taurus heparan sulfate-glucosamine 3-sulfotransferase 5 (HS3ST5), transcript variant X1, mRNA","Q8IZT8",660,0,"Heparan sulfate glucosamine 3-O-sulfotransferase 5",".",".",".",".","pfam00685","Sulfotransfer_1","Sulfotransferase domain.","GO:0006024|glycosaminoglycan biosynthetic process;GO:0015015|heparan sulfate proteoglycan biosynthetic process, enzymatic modification;GO:0050819|negative regulation of coagulation;GO:0006477|protein sulfation;GO:0046596|regulation of viral entry into host cell;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0050656|3'-phosphoadenosine 5'-phosphosulfate binding;GO:0008467|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity;","K08104","HS3ST5; [heparan sulfate]-glucosamine 3-sulfotransferase 5 [EC:2.8.2.23]"]
["gene12211",12,16,37,19.7344621528398,47,89,79,78.7458520665562,0.250609544946699,-1.99648673136474,0.00130251868838346,0.0223196160349961,"down","yes","LOC112448040","protein_coding","chrNC_037336.1:40933459-40952448:-","gi|742189243|ref|XP_010854995.1|",1250,0,"PREDICTED: transmembrane protein FLJ37396 [Bison bison bison]","gi|742189242|ref|XM_010856693.1|",1209,0,"PREDICTED: Bison bison bison uncharacterized LOC105000705 (LOC105000705), mRNA",".",".",".",".",".",".",".",".","pfam15082","DUF4549","Domain of unknown function (DUF4549). This family of proteins is found in eukaryotes. Proteins in this family are typically between 143 and 1871 amino acids in length. The human member of this family is C6orf183.",".",".",".",".","."]
["gene12219",404,198,264,251.259999437273,526,365,477,502.736545910592,0.499784631694465,-1.00062155544567,0.00280750621628642,0.039323004347996,"down","yes","AFG1L","protein_coding","chrNC_037336.1:41655110-41851120:-","gi|300798589|ref|NP_001179844.1|",2511,0,"lactation elevated protein 1 [Bos taurus]","gi|300798588|ref|NM_001192915.1|",2545,0,"Bos taurus lactation elevated 1 (LACE1), mRNA","Q8WV93",871,0,"AFG1-like ATPase","PA4438",244,{"v":1e-71,"d":"1.00E-71"},"COG1485","pfam03969","AFG1_ATPase","AFG1-like ATPase. This family of proteins contains a P-loop motif and are predicted to be ATPases.","GO:0006123|mitochondrial electron transport, cytochrome c to oxygen;GO:0035694|mitochondrial protein catabolic process;GO:0007005|mitochondrion organization;","GO:0031966|mitochondrial membrane;GO:0005739|mitochondrion;","GO:0005524|ATP binding;GO:0016787|hydrolase activity;","K18798","AFG1, LACE1; protein AFG1"]
["gene12498",378,255,321,280.669636109969,555,500,521,579.001949431472,0.484747307648206,-1.04469520945548,0.00130714805242301,0.0223854988497485,"down","yes","AHI1","protein_coding","chrNC_037336.1:73329650-73549068:-","gi|594070898|ref|XP_006059325.1|",5752,0,"PREDICTED: jouberin isoform X1 [Bubalus bubalis]","gi|594070897|ref|XM_006059263.1|",4530,0,"PREDICTED: Bubalus bubalis Abelson helper integration site 1 (AHI1), transcript variant X1, mRNA","Q8N157",1778,0,"Jouberin",".",".",".",".","pfam00018","SH3_1","SH3 domain. SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.","GO:0034613|cellular protein localization;GO:0007417|central nervous system development;GO:0060271|cilium morphogenesis;GO:0035844|cloaca development;GO:0001947|heart looping;GO:0030902|hindbrain development;GO:0070121|Kupffer's vesicle development;GO:0070986|left/right axis specification;GO:0001738|morphogenesis of a polarized epithelium;GO:0043066|negative regulation of apoptotic process;GO:0071599|otic vesicle development;GO:0035845|photoreceptor cell outer segment organization;GO:0030862|positive regulation of polarized epithelial cell differentiation;GO:0002092|positive regulation of receptor internalization;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0039023|pronephric duct morphogenesis;GO:0039008|pronephric nephron tubule morphogenesis;GO:0050795|regulation of behavior;GO:0010842|retina layer formation;GO:0065001|specification of axis polarity;GO:0007169|transmembrane receptor protein tyrosine kinase signaling pathway;GO:0016192|vesicle-mediated transport;","GO:0005912|adherens junction;GO:0005911|cell-cell junction;GO:0005814|centriole;GO:0005813|centrosome;GO:0036064|ciliary basal body;GO:0005929|cilium;GO:0005829|cytosol;GO:0036038|TCTN-B9D complex;","GO:0042802|identical protein binding;","K16740","AHI1; jouberin"]
["gene12525",18,9,28,16.240083116938,150,83,100,122.622470599181,0.132439699164293,-2.91659245610621,{"v":3.83975337707447e-06,"d":"3.84E-06"},0.00018758904726252,"down","yes","PERP","protein_coding","chrNC_037336.1:75912275-75926604:-","gi|77735653|ref|NP_001029522.1|",852,{"v":4e-107,"d":"4.00E-107"},"p53 apoptosis effector related to PMP-22 [Bos taurus]","gi|402693270|ref|NM_001034350.2|",1974,0,"Bos taurus PERP, TP53 apoptosis effector (PERP), mRNA","Q96FX8",304,{"v":1e-97,"d":"1.00E-97"},"p53 apoptosis effector related to PMP-22",".",".",".",".","pfam13903","Claudin_2","PMP-22/EMP/MP20/Claudin tight junction. Members of this family are claudins, that form tight junctions between cells.","GO:0097202|activation of cysteine-type endopeptidase activity;GO:0097186|amelogenesis;GO:0070268|cornification;GO:0002934|desmosome organization;GO:0034113|heterotypic cell-cell adhesion;GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;GO:0007219|Notch signaling pathway;GO:0045862|positive regulation of proteolysis;GO:0042981|regulation of apoptotic process;","GO:0030057|desmosome;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0005739|mitochondrion;GO:0005886|plasma membrane;",".","K10136","PERP; TP53 apoptosis effector"]
["gene12536",842,617,1105,761.01597862351,1632,4344,2913,3255.69754693617,0.233748979336141,-2.09696802939468,{"v":1.5928408674189e-06,"d":"1.59E-06"},{"v":9.14393215056913e-05,"d":"9.14E-05"},"down","yes","CITED2","protein_coding","chrNC_037336.1:77046163-77048572:-","gi|675654626|ref|XP_008993415.1|",1152,{"v":6e-150,"d":"6.00E-150"},"PREDICTED: cbp/p300-interacting transactivator 2 [Callithrix jacchus]","gi|115495012|ref|NM_001075819.1|",1933,0,"Bos taurus Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2 (CITED2), mRNA","Q0VCT9",387,{"v":1e-128,"d":"1.00E-128"},"Cbp/p300-interacting transactivator 2",".",".",".",".","pfam04487","CITED","CITED. CITED, CBP/p300-interacting transactivator with ED-rich tail, are characterized by a conserved 32-amino acid sequence at the C-terminus. CITED proteins do not bind DNA directly and are thought to function as transcriptional co-activators.","GO:0035802|adrenal cortex formation;GO:0060349|bone morphogenesis;GO:0061308|cardiac neural crest cell development involved in heart development;GO:0007417|central nervous system development;GO:0021602|cranial nerve morphogenesis;GO:0046697|decidualization;GO:0048596|embryonic camera-type eye morphogenesis;GO:0060971|embryonic heart tube left/right pattern formation;GO:0001892|embryonic placenta development;GO:0060136|embryonic process involved in female pregnancy;GO:0003197|endocardial cushion development;GO:0048821|erythrocyte development;GO:0030851|granulocyte differentiation;GO:0001947|heart looping;GO:0002244|hematopoietic progenitor cell differentiation;GO:0070986|left/right axis specification;GO:0060972|left/right pattern formation;GO:0002089|lens morphogenesis in camera-type eye;GO:0001889|liver development;GO:0008584|male gonad development;GO:0043066|negative regulation of apoptotic process;GO:0001843|neural tube closure;GO:1900164|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry;GO:0003151|outflow tract morphogenesis;GO:0007422|peripheral nervous system development;GO:0045787|positive regulation of cell cycle;GO:0022409|positive regulation of cell-cell adhesion;GO:2000020|positive regulation of male gonad development;GO:0035360|positive regulation of peroxisome proliferator activated receptor signaling pathway;GO:0045893|positive regulation of transcription, DNA-templated;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0061156|pulmonary artery morphogenesis;GO:0003156|regulation of organ formation;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0043627|response to estrogen;GO:0001666|response to hypoxia;GO:0007530|sex determination;GO:0035914|skeletal muscle cell differentiation;GO:0048536|spleen development;GO:0048538|thymus development;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0001829|trophectodermal cell differentiation;GO:0001570|vasculogenesis;GO:0060412|ventricular septum morphogenesis;","GO:0000790|nuclear chromatin;GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0001102|RNA polymerase II activating transcription factor binding;GO:0001105|RNA polymerase II transcription coactivator activity;GO:0046332|SMAD binding;GO:0003713|transcription coactivator activity;GO:0003714|transcription corepressor activity;",".","."]
["gene1261",94,60,58,61.9746997642693,184,162,153,183.454166703655,0.337821161971103,-1.56566838985493,0.000570452320477396,0.0116922235312792,"down","yes","ITGB2","protein_coding","chrNC_037328.1:144759539-144788839:-","gi|41386721|ref|NP_786975.1|",3573,0,"integrin beta-2 precursor [Bos taurus]","gi|742096832|ref|XM_010834881.1|",2231,0,"PREDICTED: Bison bison bison integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2), mRNA","P32592",1380,0,"Integrin beta-2",".",".",".",".","pfam00362","Integrin_beta","Integrin, beta chain. Integrins have been found in animals and their homologues have also been found in cyanobacteria, probably due to horizontal gene transfer. The sequences repeats have been trimmed due to an overlap with EGF.","GO:0007160|cell-matrix adhesion;GO:0071404|cellular response to low-density lipoprotein particle stimulus;GO:0035987|endodermal cell differentiation;GO:0034113|heterotypic cell-cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0007159|leukocyte cell-cell adhesion;GO:0030593|neutrophil chemotaxis;GO:0006909|phagocytosis;GO:0043315|positive regulation of neutrophil degranulation;GO:0032930|positive regulation of superoxide anion generation;GO:0043113|receptor clustering;GO:0031623|receptor internalization;GO:0050730|regulation of peptidyl-tyrosine phosphorylation;","GO:0009986|cell surface;GO:0034687|integrin alphaL-beta2 complex;GO:0016020|membrane;GO:0044853|plasma membrane raft;","GO:0050839|cell adhesion molecule binding;GO:0031072|heat shock protein binding;GO:0030369|ICAM-3 receptor activity;GO:0046872|metal ion binding;GO:0019901|protein kinase binding;","K06464","ITGB2; integrin beta 2"]
["gene12662",435,633,664,524.745163677304,2590,616,1788,1839.54322063074,0.285258404256128,-1.8096587032024,{"v":5.5836317700791e-05,"d":"5.58E-05"},0.00178594840843191,"down","yes","TIAM2","protein_coding","chrNC_037336.1:91634939-91871689:+","gi|982935533|ref|XP_015328402.1|",8402,0,"PREDICTED: LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 2 [Bos taurus]","gi|982988133|ref|XM_010799033.2|",6785,0,"PREDICTED: Bos taurus T-cell lymphoma invasion and metastasis 2 (TIAM2), mRNA","Q8IVF5",2787,0,"T-lymphoma invasion and metastasis-inducing protein 2",".",".",".",".","pfam00621","RhoGEF","RhoGEF domain. Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0035556|intracellular signal transduction;GO:0043065|positive regulation of apoptotic process;GO:0019216|regulation of lipid metabolic process;GO:0035023|regulation of Rho protein signal transduction;GO:0051056|regulation of small GTPase mediated signal transduction;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0030175|filopodium;GO:0030426|growth cone;GO:0030027|lamellipodium;GO:0016020|membrane;","GO:0005096|GTPase activator activity;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0005089|Rho guanyl-nucleotide exchange factor activity;","K16847","TIAM2; T-lymphoma invasion and metastasis-inducing protein 2"]
["gene12716",1,0,0,0.260623236836211,0,55,37,33.5403131671894,0.00777044732817712,-7.00778663074384,{"v":1.94637626709745e-05,"d":"1.95E-05"},0.000744397604243396,"down","yes","SLC22A2","protein_coding","chrNC_037336.1:96367973-96399947:-","gi|194669835|ref|XP_599284.3|",2640,0,"PREDICTED: solute carrier family 22 member 2 isoform X1 [Bos taurus]","gi|982988220|ref|XM_599284.9|",3016,0,"PREDICTED: Bos taurus solute carrier family 22 member 2 (LOC521027), transcript variant X1, mRNA","O02713",916,0,"Solute carrier family 22 member 2",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0015872|dopamine transport;GO:0006836|neurotransmitter transport;GO:0015874|norepinephrine transport;","GO:0005887|integral component of plasma membrane;","GO:0005277|acetylcholine transmembrane transporter activity;GO:0005329|dopamine transmembrane transporter activity;GO:0005333|norepinephrine transmembrane transporter activity;GO:0008514|organic anion transmembrane transporter activity;GO:0015651|quaternary ammonium group transmembrane transporter activity;GO:0008513|secondary active organic cation transmembrane transporter activity;","K08199","SLC22A2, OCT2; MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 2"]
["gene1286",2281,500,1790,1308.0881669852,7998,3361,6358,6517.90802945794,0.20069141219441,-2.31694921136876,0.0002847825210111,0.00672176195505347,"down","yes","S100B","protein_coding","chrNC_037328.1:146272657-146280008:-","gi|77736057|ref|NP_001029727.1|",381,{"v":6e-41,"d":"6.00E-41"},"protein S100-B [Bos taurus]","gi|402692387|ref|NM_001034555.3|",1427,0,"Bos taurus S100 calcium binding protein B (S100B), mRNA","P02638",151,{"v":2e-42,"d":"2.00E-42"},"Protein S100-B",".",".",".",".","pfam01023","S_100","S-100/ICaBP type calcium binding domain. The S-100 domain is a subfamily of the EF-hand calcium binding proteins.","GO:0048143|astrocyte activation;GO:0007409|axonogenesis;GO:0007611|learning or memory;GO:0007613|memory;GO:0071638|negative regulation of monocyte chemotactic protein-1 production;GO:0016310|phosphorylation;GO:0045917|positive regulation of complement activation;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0048168|regulation of neuronal synaptic plasticity;GO:0006417|regulation of translation;","GO:0005737|cytoplasm;GO:0043025|neuronal cell body;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0001726|ruffle;","GO:0005509|calcium ion binding;GO:0048306|calcium-dependent protein binding;GO:0019210|kinase inhibitor activity;GO:0042803|protein homodimerization activity;GO:0050786|RAGE receptor binding;GO:0044548|S100 protein binding;GO:0048156|tau protein binding;GO:0008270|zinc ion binding;",".","."]
["gene12860",61,37,33,38.1585854867201,107,134,151,143.676426050808,0.265586961866842,-1.91274377091243,0.00017621205986665,0.00459661310018389,"down","yes","SFXN1","protein_coding","chrNC_037337.1:5614077-5675275:-","gi|741938893|ref|XP_010807110.1|",1558,0,"PREDICTED: sideroflexin-1 isoform X1 [Bos taurus]","gi|982935794|ref|XM_010808808.2|",2536,0,"PREDICTED: Bos taurus sideroflexin 1 (SFXN1), transcript variant X1, mRNA","Q5E9M8",478,{"v":4e-168,"d":"4.00E-168"},"Sideroflexin-1",".",".",".",".","pfam03820","Mtc","Tricarboxylate carrier.","GO:0030218|erythrocyte differentiation;GO:0055072|iron ion homeostasis;GO:0006826|iron ion transport;","GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;","GO:0015075|ion transmembrane transporter activity;",".","."]
["gene12867",75,45,285,121.823703905321,641,469,611,632.256950509491,0.192680687507115,-2.37571611813685,{"v":7.17166163772545e-07,"d":"7.17E-07"},{"v":4.55711978142416e-05,"d":"4.56E-05"},"down","yes","GCNT4","protein_coding","chrNC_037337.1:6500605-6532598:-","gi|528909994|ref|XP_005200929.1|",2211,0,"PREDICTED: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4 [Bos taurus]","gi|982988466|ref|XM_010800623.2|",5031,0,"PREDICTED: Bos taurus glucosaminyl (N-acetyl) transferase 4, core 2 (GCNT4), transcript variant X2, mRNA","Q9P109",758,0,"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4",".",".",".",".","pfam02485","Branch","Core-2/I-Branching enzyme. This is a family of two different beta-1,6-N-acetylglucosaminyltransferase enzymes, I-branching enzyme and core-2 branching enzyme. I-branching enzyme is responsible for the production of the blood group I-antigen during embryonic development. Core-2 branching enzyme forms crucial side-chain branches in O-glycans.","GO:0005975|carbohydrate metabolic process;GO:0048872|homeostasis of number of cells;GO:0002121|inter-male aggressive behavior;GO:0060993|kidney morphogenesis;GO:0016266|O-glycan processing;GO:0006493|protein O-linked glycosylation;GO:0042403|thyroid hormone metabolic process;GO:0048729|tissue morphogenesis;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0003829|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity;GO:0008109|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity;","K09663","GCNT4; beta-1,6-N-acetylglucosaminyltransferase 4 [EC:2.4.1.-]"]
["gene12925",6,6,11,6.90838346594594,68,18,46,48.6267592432312,0.142069584184917,-2.81533037522915,0.0024338080980143,0.0353739066961008,"down","yes","GPR137C","protein_coding","chrNC_037337.1:11553052-11615725:-","gi|593768742|ref|XP_007122824.1|",1763,0,"PREDICTED: integral membrane protein GPR137C [Physeter catodon]","gi|982988526|ref|XM_868651.7|",3976,0,"PREDICTED: Bos taurus G protein-coupled receptor 137C (GPR137C), mRNA","Q8N3F9",632,0,"Integral membrane protein GPR137C",".",".",".",".","pfam04247","SirB","Invasion gene expression up-regulator, SirB. SirB up-regulates Salmonella typhimurium invasion gene transcription. It is, however, not essential for the expression of these genes. Its function is unknown.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene13007",3,3,0,1.76502274812841,14,22,23,21.6088562147807,0.081680526289083,-3.61386402786601,0.00287682171888364,0.0400188203127593,"down","yes","PAQR5","protein_coding","chrNC_037337.1:16171984-16270692:+","gi|297459418|ref|XP_605853.5|",1749,0,"PREDICTED: membrane progestin receptor gamma [Bos taurus]","gi|742095105|ref|XM_010834497.1|",3611,0,"PREDICTED: Bison bison bison progestin and adipoQ receptor family member V (PAQR5), transcript variant X4, mRNA","Q9NXK6",585,0,"Membrane progestin receptor gamma","YDR492w",68.6,{"v":3e-11,"d":"3.00E-11"},"COG1272","pfam03006","HlyIII","Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolizm. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.","GO:0007275|multicellular organismal development;GO:0048477|oogenesis;GO:0048545|response to steroid hormone;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005496|steroid binding;GO:0003707|steroid hormone receptor activity;",".","."]
["gene1301",269,237,239,221.178811113239,444,373,406,449.394387987167,0.492170834851535,-1.02276892604236,0.00248484496918222,0.0359691079734845,"down","yes","SETD4","protein_coding","chrNC_037328.1:148316035-148435158:-","gi|329663327|ref|NP_001192753.1|",2138,0,"SET domain-containing protein 4 [Bos taurus]","gi|982912498|ref|XM_010801703.2|",3920,0,"PREDICTED: Bos taurus SET domain containing 4 (SETD4), transcript variant X2, mRNA","Q9NVD3",662,0,"SET domain-containing protein 4",".",".",".",".","pfam09273","Rubis-subs-bind","Rubisco LSMT substrate-binding. Members of this family adopt a multihelical structure, with an irregular array of long and short alpha-helices. They allow binding of the protein to substrate, such as the N-terminal tails of histones H3 and H4 and the large subunit of the Rubisco holoenzyme complex.","GO:0018026|peptidyl-lysine monomethylation;GO:0018023|peptidyl-lysine trimethylation;GO:0042254|ribosome biogenesis;","GO:0005730|nucleolus;","GO:0016279|protein-lysine N-methyltransferase activity;",".","."]
["gene1309",700,448,657,531.032699350424,1584,658,1334,1315.06430844454,0.403807400094775,-1.30826074543092,0.00285476862391419,0.0398285592219539,"down","yes","DOPEY2","protein_coding","chrNC_037328.1:148460234-148590945:+","gi|528900255|ref|XP_005196071.1|",11368,0,"PREDICTED: protein dopey-2 isoform X1 [Bos taurus]","gi|982977007|ref|XM_005196014.3|",7327,0,"PREDICTED: Bos taurus dopey family member 2 (DOPEY2), transcript variant X1, mRNA","Q9Y3R5",3648,0,"Protein dopey-2","SPAPB21F2.02",168,{"v":1e-40,"d":"1.00E-40"},"COG5221","pfam04118","Dopey_N","Dopey, N-terminal. DopA is the founding member of the Dopey family and is required for correct cell morphology and spatiotemporal organisation of multicellular structures in the filamentous fungus Aspergillus nidulans. DopA homologues are found in mammals. S. cerevisiae DOP1 is essential for viability and, affects cellular morphogenesis.","GO:0050890|cognition;GO:0007029|endoplasmic reticulum organization;GO:0006895|Golgi to endosome transport;GO:0007275|multicellular organismal development;GO:0015031|protein transport;","GO:0005829|cytosol;GO:0005768|endosome;GO:0070062|extracellular exosome;GO:0000139|Golgi membrane;GO:0005802|trans-Golgi network;",".",".","."]
["gene13285",126,62,49,68.2059839989683,288,82,275,237.005734955023,0.287781998236928,-1.79695174557004,0.0032547057670465,0.0438225626425689,"down","yes","BRB","protein_coding","chrNC_037337.1:26256262-26257897:+","gi|27806923|ref|NP_776316.1|",623,{"v":1e-77,"d":"1.00E-77"},"brain ribonuclease precursor [Bos taurus]","gi|942068821|ref|XM_014479717.1|",820,0,"PREDICTED: Bos mutus brain ribonuclease (LOC102286301), transcript variant X2, mRNA","P39873",244,{"v":4e-79,"d":"4.00E-79"},"Brain ribonuclease",".",".",".",".","pfam00074","RnaseA","Pancreatic ribonuclease. Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.",".","GO:0005576|extracellular region;","GO:0004519|endonuclease activity;GO:0003676|nucleic acid binding;GO:0004540|ribonuclease activity;","K01168","RNASE1_2; pancreatic ribonuclease [EC:3.1.27.5]"]
["gene1329",16,0,4,5.39845832381179,43,57,37,50.3463161831183,0.107226481162527,-3.22126685024917,0.00325396210852846,0.0438225626425689,"down","yes","KCNJ15","protein_coding","chrNC_037328.1:150539880-150597398:+","gi|965918643|ref|XP_014948194.1|",1856,0,"PREDICTED: ATP-sensitive inward rectifier potassium channel 15 isoform X2 [Ovis aries]","gi|982912438|ref|XM_005202075.3|",4154,0,"PREDICTED: Bos taurus potassium channel, inwardly rectifying subfamily J, member 15 (KCNJ15), transcript variant X3, mRNA","Q99712",691,0,"ATP-sensitive inward rectifier potassium channel 15",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.","GO:0010107|potassium ion import;GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;","GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0015467|G-protein activated inward rectifier potassium channel activity;GO:0005242|inward rectifier potassium channel activity;","K05008","KCNJ15; potassium inwardly-rectifying channel subfamily J member 15"]
["gene13293",135,88,53,80.300739324298,299,158,225,250.959594767592,0.31997477282613,-1.64396992900383,0.00101310149326885,0.0182364660595921,"down","yes","RNASE6","protein_coding","chrNC_037337.1:26370330-26372017:-","gi|27807073|ref|NP_777019.1|",745,{"v":2e-95,"d":"2.00E-95"},"ribonuclease K6 precursor [Bos taurus]","gi|741939766|ref|XM_010809076.1|",1088,0,"PREDICTED: Bos taurus ribonuclease A family member k6 (RNASE6), transcript variant X1, mRNA","P08904",291,{"v":8e-97,"d":"8.00E-97"},"Ribonuclease K6",".",".",".",".","pfam00074","RnaseA","Pancreatic ribonuclease. Ribonucleases. Members include pancreatic RNAase A and angiogenins. Structure is an alpha+beta fold -- long curved beta sheet and three helices.","GO:0019731|antibacterial humoral response;GO:0050829|defense response to Gram-negative bacterium;GO:0050830|defense response to Gram-positive bacterium;GO:0051607|defense response to virus;GO:0045087|innate immune response;","GO:0031410|cytoplasmic vesicle;GO:0005615|extracellular space;GO:0005764|lysosome;","GO:0004519|endonuclease activity;GO:0003676|nucleic acid binding;GO:0004540|ribonuclease activity;","K01172","RNASE6_7_8; ribonuclease 6/7/8 [EC:3.1.27.-]"]
["gene13437",519,450,442,418.484177615741,1141,2211,1700,1851.53281630712,0.226020394523931,-2.14547513750783,{"v":1.43534435820355e-07,"d":"1.44E-07"},{"v":1.14710952055758e-05,"d":"1.15E-05"},"down","yes","RYR3","protein_coding","chrNC_037337.1:28728178-29286652:-","gi|982936631|ref|XP_015328590.1|",23993,0,"PREDICTED: ryanodine receptor 3 [Bos taurus]","gi|982988941|ref|XM_015465016.1|",15360,0,"PREDICTED: Bos taurus ryanodine receptor 3 (RYR3), mRNA","Q15413",8927,0,"Ryanodine receptor 3",".",".",".",".","pfam06459","RR_TM4-6","Ryanodine Receptor TM 4-6. This region covers TM regions 4-6 of the ryanodine receptor 1 family.","GO:0070588|calcium ion transmembrane transport;GO:0006816|calcium ion transport;GO:0071318|cellular response to ATP;GO:0071313|cellular response to caffeine;GO:0071277|cellular response to calcium ion;GO:0071286|cellular response to magnesium ion;GO:0034220|ion transmembrane transport;GO:0051481|negative regulation of cytosolic calcium ion concentration;GO:0051289|protein homotetramerization;GO:1903779|regulation of cardiac conduction;","GO:0016021|integral component of membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0016529|sarcoplasmic reticulum;GO:0033017|sarcoplasmic reticulum membrane;","GO:0005509|calcium ion binding;GO:0048763|calcium-induced calcium release activity;GO:0015278|calcium-release channel activity;GO:0005516|calmodulin binding;GO:0005219|ryanodine-sensitive calcium-release channel activity;","K04963","RYR3; ryanodine receptor 3"]
["gene13447",470,623,2178,995.571953457172,61896,18805,49261,47817.8364030252,0.020820096188923,-5.58587945586545,{"v":3.49865285003438e-06,"d":"3.50E-06"},0.000173671017539163,"down","yes","ACTC1","protein_coding","chrNC_037337.1:30288631-30293908:-","gi|726987387|ref|XP_010390022.1|",2048,0,"PREDICTED: actin, alpha cardiac muscle 1 [Corvus cornix cornix]","gi|402692809|ref|NM_001034585.2|",1391,0,"Bos taurus actin, alpha, cardiac muscle 1 (ACTC1), mRNA","Q6P640",789,0,"Actin, alpha cardiac muscle 1","SPBC32H8.12c",711,0,"COG5277","pfam00022","Actin","Actin.","GO:0090131|mesenchyme migration;GO:0010628|positive regulation of gene expression;","GO:0044297|cell body;GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0030175|filopodium;GO:0030027|lamellipodium;","GO:0005524|ATP binding;","K12314","ACTC1; actin, alpha cardiac muscle"]
["gene13473",52,47,53,45.2325858194222,136,107,124,134.860768315217,0.335402106813582,-1.57603634373119,0.00144459558131581,0.0241592945665424,"down","yes","RASGRP1","protein_coding","chrNC_037337.1:34098467-34276505:-","gi|221136838|ref|NP_001137550.1|",4191,0,"RAS guanyl-releasing protein 1 [Bos taurus]","gi|982936741|ref|XM_015473118.1|",4747,0,"PREDICTED: Bos taurus RAS guanyl releasing protein 1 (RASGRP1), transcript variant X2, mRNA","O95267",1504,0,"RAS guanyl-releasing protein 1",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0090630|activation of GTPase activity;GO:0030154|cell differentiation;GO:0001816|cytokine production;GO:0002437|inflammatory response to antigenic stimulus;GO:0000165|MAPK cascade;GO:0043303|mast cell degranulation;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0032725|positive regulation of granulocyte macrophage colony-stimulating factor production;GO:0043547|positive regulation of GTPase activity;GO:1902715|positive regulation of interferon-gamma secretion;GO:0046330|positive regulation of JNK cascade;GO:0043406|positive regulation of MAP kinase activity;GO:0032825|positive regulation of natural killer cell differentiation;GO:0045954|positive regulation of natural killer cell mediated cytotoxicity;GO:0001934|positive regulation of protein phosphorylation;GO:0046579|positive regulation of Ras protein signal transduction;GO:0033089|positive regulation of T cell differentiation in thymus;GO:0032760|positive regulation of tumor necrosis factor production;GO:0051259|protein oligomerization;GO:0007265|Ras protein signal transduction;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0014066|regulation of phosphatidylinositol 3-kinase signaling;GO:0032252|secretory granule localization;GO:0007165|signal transduction;GO:0047496|vesicle transport along microtubule;","GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0000139|Golgi membrane;GO:0042629|mast cell granule;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0019992|diacylglycerol binding;GO:0005096|GTPase activator activity;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0008289|lipid binding;GO:0031210|phosphatidylcholine binding;GO:0001786|phosphatidylserine binding;GO:0042803|protein homodimerization activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;GO:0008270|zinc ion binding;","K04350","RASGRP1; RAS guanyl-releasing protein 1"]
["gene1360",180,214,48,131.785604393918,650,775,770,805.31374869599,0.163645044688871,-2.61135817787608,{"v":3.85704694792434e-09,"d":"3.86E-09"},{"v":4.4373147770657e-07,"d":"4.44E-07"},"down","yes","GALNT15","protein_coding","chrNC_037328.1:153179306-153226107:+","gi|329744620|ref|NP_001180111.1|",2648,0,"polypeptide N-acetylgalactosaminyltransferase 15 precursor [Bos taurus]","gi|329744619|ref|NM_001193182.1|",3986,0,"Bos taurus polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15), mRNA","Q8N3T1",775,0,"Polypeptide N-acetylgalactosaminyltransferase 15",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0016266|O-glycan processing;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;GO:0030133|transport vesicle;","GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["gene13744",3951,2811,4305,3273.09543767248,11601,4404,8205,8914.0794178232,0.367182665113809,-1.44543014491743,0.00153003993871535,0.0253210959927423,"down","yes","ARPP19","protein_coding","chrNC_037337.1:57819020-57836975:+","gi|731276812|ref|XP_010607367.1|",509,{"v":5e-56,"d":"5.00E-56"},"PREDICTED: cAMP-regulated phosphoprotein 19 isoform X1 [Fukomys damarensis]","gi|982937168|ref|XM_005211788.3|",4501,0,"PREDICTED: Bos taurus cAMP regulated phosphoprotein 19kDa (ARPP19), transcript variant X2, mRNA","Q28055",200,{"v":2e-57,"d":"2.00E-57"},"cAMP-regulated phosphoprotein 19",".",".",".",".","pfam04667","Endosulfine","cAMP-regulated phosphoprotein/endosulfine conserved region. Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolizm. In both cases the region occupies the majority of the protein.","GO:0051301|cell division;GO:0000086|G2/M transition of mitotic cell cycle;GO:0000278|mitotic cell cycle;GO:0035308|negative regulation of protein dephosphorylation;","GO:0005737|cytoplasm;","GO:0019212|phosphatase inhibitor activity;GO:0051721|protein phosphatase 2A binding;GO:0004864|protein phosphatase inhibitor activity;GO:0019888|protein phosphatase regulator activity;",".","."]
["gene13805",0,0,0,0,0,176,59,85.8872125608834,{"$error":"#NAME?"},{"$error":"#NAME?"},{"v":1.02422387102544e-10,"d":"1.02E-10"},{"v":1.6794328312774e-08,"d":"1.68E-08"},"down","yes","SLC12A1","protein_coding","chrNC_037337.1:62094457-62182501:-","gi|528966552|ref|XP_005211956.1|",5575,0,"PREDICTED: solute carrier family 12 member 1 isoform X1 [Bos taurus]","gi|982989706|ref|XM_015465136.1|",4670,0,"PREDICTED: Bos taurus solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1), transcript variant X2, mRNA","Q13621",1999,0,"Solute carrier family 12 member 1","SPBC18H10.16",225,{"v":4e-59,"d":"4.00E-59"},"COG0531","pfam00324","AA_permease","Amino acid permease.","GO:0034220|ion transmembrane transport;GO:0006811|ion transport;","GO:0016324|apical plasma membrane;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0008511|sodium:potassium:chloride symporter activity;","K14425","SLC12A1, NKCC2; solute carrier family 12 (sodium/potassium/chloride transporter), member 1"]
["gene13971",924,798,1192,868.423566104377,4461,1385,3314,3371.92138569919,0.257545614730962,-1.95710011960874,{"v":1.03091960439105e-05,"d":"1.03E-05"},0.000442303266659865,"down","yes","HSPA2","protein_coding","chrNC_037337.1:76679952-76681862:+","gi|426233526|ref|XP_004010768.1|",3069,0,"PREDICTED: heat shock-related 70 kDa protein 2 [Ovis aries]","gi|75775318|gb|BC105156.1|",1908,0,"Bos taurus heat shock 70kDa protein 2, mRNA (cDNA clone MGC:127701 IMAGE:7961903), complete cds","P34933",1184,0,"Heat shock-related 70 kDa protein 2",".",".",".",".","pfam00012","HSP70","Hsp70 protein. Hsp70 chaperones help to fold many proteins. Hsp70 assisted folding involves repeated cycles of substrate binding and release. Hsp70 activity is ATP dependent. Hsp70 proteins are made up of two regions: the amino terminus is the ATPase domain and the carboxyl terminus is the substrate binding region.","GO:0030154|cell differentiation;GO:0009409|response to cold;GO:0009408|response to heat;GO:0007283|spermatogenesis;","GO:0036128|CatSper complex;GO:0005737|cytoplasm;GO:0072687|meiotic spindle;","GO:0005524|ATP binding;","K03283","HSPA1_8; heat shock 70kDa protein 1/8"]
["gene14",7599,1357,7384,4692.97500996394,17881,11762,16304,16885.1569803914,0.277934935127571,-1.84718090890017,{"v":2.05641923016855e-05,"d":"2.06E-05"},0.000779172603664527,"down","yes","RCAN1","protein_coding","chrNC_037328.1:882073-1002231:+","gi|528935790|ref|XP_005201167.1|",1194,{"v":7e-155,"d":"7.00E-155"},"PREDICTED: calcipressin-1 isoform X1 [Bos taurus]","gi|982909390|ref|XM_005201110.3|",2515,0,"PREDICTED: Bos taurus regulator of calcineurin 1 (RCAN1), transcript variant X1, mRNA","P53805",416,{"v":1e-137,"d":"1.00E-137"},"Calcipressin-1",".",".",".",".","pfam04847","Calcipressin","Calcipressin. Calcipressin is also known as calcineurin-binding protein, since it inhibits calcineurin-mediated transcriptional modulation by binding to calcineurin's catalytic domain.","GO:0008015|blood circulation;GO:0033173|calcineurin-NFAT signaling cascade;GO:0007417|central nervous system development;GO:0070885|negative regulation of calcineurin-NFAT signaling cascade;GO:0070884|regulation of calcineurin-NFAT signaling cascade;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0008597|calcium-dependent protein serine/threonine phosphatase regulator activity;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0042802|identical protein binding;","K17901","RCAN1, MCIP1; calcipressin-1"]
["gene14008",9,24,104,42.1514833277267,401,278,381,389.434218843889,0.108237749247771,-3.20772435030173,{"v":2.36536322076124e-07,"d":"2.37E-07"},{"v":1.7574525534255e-05,"d":"1.76E-05"},"down","yes","ARG2","protein_coding","chrNC_037337.1:79499746-79534867:+","gi|296482971|tpg|DAA25086.1|",1662,0,"TPA: arginase 2 precursor [Bos taurus]","gi|62988295|ref|NM_001017942.1|",1418,0,"Bos taurus arginase 2 (ARG2), mRNA","Q58DL1",641,0,"Arginase-2, mitochondrial","SPAC3H1.07",234,{"v":2e-71,"d":"2.00E-71"},"COG0010","pfam00491","Arginase","Arginase family.","GO:0002250|adaptive immune response;GO:0006525|arginine metabolic process;GO:0045087|innate immune response;GO:0000050|urea cycle;","GO:0005739|mitochondrion;","GO:0004053|arginase activity;GO:0046872|metal ion binding;","K01476","E3.5.3.1, rocF, arg; arginase [EC:3.5.3.1]"]
["gene14039",257,251,281,235.538488391637,716,386,626,635.244182374032,0.370784172334146,-1.43134843394009,0.000660235422292608,0.0132005443822217,"down","yes","SMOC1","protein_coding","chrNC_037337.1:81593307-81739429:+","gi|528966712|ref|XP_005212006.1|",2222,0,"PREDICTED: SPARC-related modular calcium-binding protein 1 isoform X1 [Bos taurus]","gi|982937486|ref|XM_005211949.3|",3501,0,"PREDICTED: Bos taurus SPARC related modular calcium binding 1 (SMOC1), transcript variant X1, mRNA","Q8BLY1",810,0,"SPARC-related modular calcium-binding protein 1",".",".",".",".","pfam00086","Thyroglobulin_1","Thyroglobulin type-1 repeat. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.","GO:0030154|cell differentiation;GO:0030198|extracellular matrix organization;GO:0001654|eye development;GO:0060173|limb development;GO:0010811|positive regulation of cell-substrate adhesion;GO:0045667|regulation of osteoblast differentiation;GO:0007165|signal transduction;","GO:0005604|basement membrane;","GO:0005509|calcium ion binding;GO:0050840|extracellular matrix binding;",".","."]
["gene14101",736,873,1215,851.06902109265,3483,880,2862,2657.88772557784,0.320205030822971,-1.64293212030509,0.000206694706214943,0.0051963202093346,"down","yes","LTBP2","protein_coding","chrNC_037337.1:85788955-85898441:-","gi|982937455|ref|XP_015328707.1|",8433,0,"PREDICTED: latent-transforming growth factor beta-binding protein 2 isoform X3 [Bos taurus]","gi|982937454|ref|XM_015473221.1|",7955,0,"PREDICTED: Bos taurus latent transforming growth factor beta binding protein 2 (LTBP2), transcript variant X3, mRNA","Q28019",3216,0,"Latent-transforming growth factor beta-binding protein 2",".",".",".",".","pfam00683","TB","TB domain. This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.",".","GO:0071953|elastic fiber;GO:0001527|microfibril;","GO:0005509|calcium ion binding;GO:0019838|growth factor binding;GO:0008201|heparin binding;GO:0050436|microfibril binding;","K08023","LTBP2_3_4; latent transforming growth factor beta binding protein 2/3/4"]
["gene14134",336,137,255,210.782746198336,797,277,718,658.727258396856,0.319984854902342,-1.64392447188209,0.000945209516886627,0.0172870337989054,"down","yes","ESRRB","protein_coding","chrNC_037337.1:87626916-87810135:+","gi|594057502|ref|XP_006052928.1|",2172,0,"PREDICTED: steroid hormone receptor ERR2 [Bubalus bubalis]","gi|982990137|ref|XM_015465239.1|",1905,0,"PREDICTED: Bos taurus estrogen related receptor beta (ESRRB), transcript variant X1, mRNA","O95718",785,0,"Steroid hormone receptor ERR2",".",".",".",".","pfam00105","zf-C4","Zinc finger, C4 type (two domains). In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.","GO:0043697|cell dedifferentiation;GO:0008283|cell proliferation;GO:0048839|inner ear development;GO:2000737|negative regulation of stem cell differentiation;GO:0045494|photoreceptor cell maintenance;GO:0045725|positive regulation of glycogen biosynthetic process;GO:0045821|positive regulation of glycolytic process;GO:1902459|positive regulation of stem cell population maintenance;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0071931|positive regulation of transcription involved in G1/S transition of mitotic cell cycle;GO:0090282|positive regulation of transcription involved in G2/M transition of mitotic cell cycle;GO:0045893|positive regulation of transcription, DNA-templated;GO:2000035|regulation of stem cell division;GO:0006355|regulation of transcription, DNA-templated;GO:0017145|stem cell division;GO:0019827|stem cell population maintenance;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0000793|condensed chromosome;GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0001047|core promoter binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0035326|enhancer binding;GO:0001158|enhancer sequence-specific DNA binding;GO:0004879|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding;GO:0000993|RNA polymerase II core binding;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0005496|steroid binding;GO:0003707|steroid hormone receptor activity;GO:0003713|transcription coactivator activity;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0008134|transcription factor binding;GO:0001205|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0001191|transcriptional repressor activity, RNA polymerase II transcription factor binding;GO:0008270|zinc ion binding;","K08553","NR3B2, ESRRB; estrogen-related receptor beta"]
["gene14148",0,0,0,0,18,8,9,12.9124821713226,{"$error":"#NAME?"},{"$error":"#NAME?"},0.00094837164286694,0.0173115747553657,"down","yes","TMEM63C","protein_coding","chrNC_037337.1:88380856-88459276:+","gi|329663882|ref|NP_001193090.1|",4063,0,"calcium permeable stress-gated cation channel 1 [Bos taurus]","gi|982937953|ref|XM_005212219.3|",5591,0,"PREDICTED: Bos taurus transmembrane protein 63C (TMEM63C), transcript variant X1, mRNA","Q9P1W3",1326,0,"Calcium permeable stress-gated cation channel 1","SPAC24H6.13",57.8,{"v":3e-07,"d":"3.00E-07"},"COG5594","pfam02714","DUF221","Domain of unknown function DUF221. This family consists of hypothetical transmembrane proteins none of which have any function, the aligned region is at 538 residues at maximum length.","GO:0006812|cation transport;","GO:0016021|integral component of membrane;","GO:0005227|calcium activated cation channel activity;",".","."]
["gene14257",116,10,18,39.0376616700123,576,209,476,463.81391676903,0.0841666458435577,-3.5706075646716,0.00261172948434093,0.0372949218807463,"down","yes","FBLN7","protein_coding","chrNC_037338.1:245532-302541:-","gi|297480027|ref|XP_002691171.1|",2280,0,"PREDICTED: fibulin-7 [Bos taurus]","gi|982990255|ref|XM_615422.8|",2193,0,"PREDICTED: Bos taurus fibulin 7 (FBLN7), mRNA","Q53RD9",811,0,"Fibulin-7",".",".",".",".","pfam07645","EGF_CA","Calcium-binding EGF domain.","GO:0007155|cell adhesion;","GO:0005576|extracellular region;GO:0005925|focal adhesion;","GO:0005509|calcium ion binding;GO:0008201|heparin binding;","K17342","FBLN7; fibulin 7"]
["gene14303",4,0,0,1.04249294734485,90,21,75,68.418833699411,0.015236929526231,-6.03628398271655,0.00374744460867719,0.0485551054178787,"down","yes","NEURL3","protein_coding","chrNC_037338.1:2518222-2526478:-","gi|194671297|ref|XP_588706.3|",1312,{"v":5e-172,"d":"5.00E-172"},"PREDICTED: E3 ubiquitin-protein ligase NEURL3 isoform X1 [Bos taurus]","gi|982990310|ref|XM_588706.7|",2618,0,"PREDICTED: Bos taurus neuralized E3 ubiquitin protein ligase 3 (NEURL3), transcript variant X1, mRNA","Q96EH8",344,{"v":1e-109,"d":"1.00E-109"},"E3 ubiquitin-protein ligase NEURL3",".",".",".",".","pfam07177","Neuralized","Neuralized. This family contains a conserved region approximately 60 residues long within eukaryotic neuralized and neuralized-like proteins. Neuralized belongs to a group of ubiquitin ligases and is required in a subset of Notch pathway-mediated cell fate decisions during development of the Drosophila nervous system. Some family members contain multiple copies of this region.",".",".","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;","K15689","NEURL3, LINCR; E3 ubiquitin-protein ligase NEURL3 [EC:2.3.2.27]"]
["gene14305",269,213,344,245.561358341132,1266,187,955,886.546186047935,0.276986537425422,-1.85211223724673,0.000175152295120634,0.00458044925030873,"down","yes","ARID5A","protein_coding","chrNC_037338.1:2557603-2569332:+","gi|78369190|ref|NP_001030426.1|",2751,0,"AT-rich interactive domain-containing protein 5A [Bos taurus]","gi|78369189|ref|NM_001035349.1|",2131,0,"Bos taurus AT-rich interaction domain 5A (ARID5A), mRNA","Q3SWY1",1064,0,"AT-rich interactive domain-containing protein 5A",".",".",".",".","pfam01388","ARID","ARID/BRIGHT DNA binding domain. This domain is know as ARID for AT-Rich Interaction Domain, and also known as the BRIGHT domain.","GO:0045087|innate immune response;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003723|RNA binding;GO:0044212|transcription regulatory region DNA binding;",".","."]
["gene1432",381,369,417,348.294998076407,1167,581,895,972.477873994278,0.358152105451868,-1.48135567170906,0.000480734203595751,0.0102586593588559,"down","yes","NIPA2","protein_coding","chrNC_037329.1:1044499-1066244:+","gi|77735549|ref|NP_001029470.1|",1437,0,"magnesium transporter NIPA2 [Bos taurus]","gi|942034844|ref|XM_014481672.1|",3183,0,"PREDICTED: Bos mutus non imprinted in Prader-Willi/Angelman syndrome 2 (NIPA2), transcript variant X3, mRNA","Q3SWX0",558,0,"Magnesium transporter NIPA2",".",".",".",".","pfam05653","Mg_trans_NIPA","Magnesium transporter NIPA. NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.","GO:0015693|magnesium ion transport;","GO:0005769|early endosome;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0015095|magnesium ion transmembrane transporter activity;",".","."]
["gene14441",397,341,364,327.011428266773,750,533,639,706.592117631658,0.462800843806245,-1.11153660003146,0.000435691713504141,0.00948909944884477,"down","yes","DUSP11","protein_coding","chrNC_037338.1:10848269-10864265:+","gi|440904531|gb|ELR55028.1|",1504,0,"RNA/RNP complex-1-interacting phosphatase, partial [Bos mutus]","gi|742227736|ref|XM_010829743.1|",1378,0,"PREDICTED: Bison bison bison dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) (DUSP11), transcript variant X1, mRNA","Q5E999",557,0,"RNA/RNP complex-1-interacting phosphatase",".",".",".",".","pfam00782","DSPc","Dual specificity phosphatase, catalytic domain. Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a \"recognition\" region.","GO:0098507|polynucleotide 5' dephosphorylation;GO:0016070|RNA metabolic process;","GO:0016607|nuclear speck;","GO:0098519|nucleotide phosphatase activity, acting on free nucleotides;GO:0016791|phosphatase activity;GO:0004651|polynucleotide 5'-phosphatase activity;GO:0004725|protein tyrosine phosphatase activity;GO:0008138|protein tyrosine/serine/threonine phosphatase activity;GO:0003723|RNA binding;","K14165","K14165; atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48]"]
["gene14543",52,51,22,37.0226858943974,407,151,312,320.162276820065,0.115637252027679,-3.11232186436641,{"v":1.25490596486332e-07,"d":"1.25E-07"},{"v":1.02004906220841e-05,"d":"1.02E-05"},"down","yes","CYP1B1","protein_coding","chrNC_037338.1:20470965-20476460:-","gi|300796335|ref|NP_001179223.1|",2603,0,"cytochrome P450 1B1 [Bos taurus]","gi|300796334|ref|NM_001192294.1|",2232,0,"Bos taurus cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1), mRNA","Q16678",818,0,"Cytochrome P450 1B1","BH0579",82.8,{"v":8e-16,"d":"8.00E-16"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0001525|angiogenesis;GO:0019369|arachidonic acid metabolic process;GO:0048514|blood vessel morphogenesis;GO:0007155|cell adhesion;GO:0006725|cellular aromatic compound metabolic process;GO:0070301|cellular response to hydrogen peroxide;GO:0071407|cellular response to organic cyclic compound;GO:0030199|collagen fibril organization;GO:0043542|endothelial cell migration;GO:0071603|endothelial cell-cell adhesion;GO:0019373|epoxygenase P450 pathway;GO:0008210|estrogen metabolic process;GO:0008631|intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0046466|membrane lipid catabolic process;GO:0033629|negative regulation of cell adhesion mediated by integrin;GO:0030336|negative regulation of cell migration;GO:0008285|negative regulation of cell proliferation;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0006809|nitric oxide biosynthetic process;GO:0097267|omega-hydroxylase P450 pathway;GO:0055114|oxidation-reduction process;GO:0045766|positive regulation of angiogenesis;GO:0043065|positive regulation of apoptotic process;GO:0046427|positive regulation of JAK-STAT cascade;GO:0010575|positive regulation of vascular endothelial growth factor production;GO:2000377|regulation of reactive oxygen species metabolic process;GO:0061304|retinal blood vessel morphogenesis;GO:0042574|retinal metabolic process;GO:0042572|retinol metabolic process;GO:0008202|steroid metabolic process;GO:0016125|sterol metabolic process;GO:0009404|toxin metabolic process;GO:0002930|trabecular meshwork development;GO:0007601|visual perception;GO:0006805|xenobiotic metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005739|mitochondrion;GO:0031090|organelle membrane;","GO:0070330|aromatase activity;GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0004497|monooxygenase activity;GO:0016712|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0019825|oxygen binding;","K07410","CYP1B1; cytochrome P450, family 1, subfamily B, polypeptide 1 [EC:1.14.14.1]"]
["gene14713",295,220,435,282.579654911657,1371,923,1095,1246.43089067703,0.226711049144623,-2.14107338992377,{"v":5.12893561912649e-09,"d":"5.13E-09"},{"v":5.71615867770695e-07,"d":"5.72E-07"},"down","yes","VRK2","protein_coding","chrNC_037338.1:40689232-40797823:+","gi|296482589|tpg|DAA24704.1|",2300,0,"TPA: vaccinia related kinase 2 [Bos taurus]","gi|115494949|ref|NM_001075851.1|",2078,0,"Bos taurus vaccinia related kinase 2 (VRK2), mRNA","Q86Y07",682,0,"Serine/threonine-protein kinase VRK2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0034599|cellular response to oxidative stress;GO:0018105|peptidyl-serine phosphorylation;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0008360|regulation of cell shape;GO:2000659|regulation of interleukin-1-mediated signaling pathway;GO:0043408|regulation of MAPK cascade;GO:0016032|viral process;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0005524|ATP binding;GO:0019904|protein domain specific binding;GO:0019901|protein kinase binding;GO:0004674|protein serine/threonine kinase activity;","K08816","VRK; vaccinia related kinase [EC:2.7.11.1]"]
["gene14942",495,300,410,353.243675775224,4982,867,3756,3536.10501664532,0.0998962627276109,-3.32342548418143,{"v":1.09290619265203e-12,"d":"1.09E-12"},{"v":2.73523741952238e-10,"d":"2.74E-10"},"down","yes","SLC1A4","protein_coding","chrNC_037338.1:63379682-63409620:+","gi|126158903|ref|NP_001075046.1|",2069,0,"neutral amino acid transporter A [Bos taurus]","gi|126158902|ref|NM_001081577.1|",4433,0,"Bos taurus solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (SLC1A4), mRNA","A2VDL4",801,0,"Neutral amino acid transporter A","aq_1330",129,{"v":2e-30,"d":"2.00E-30"},"COG1301","pfam00375","SDF","Sodium:dicarboxylate symporter family.","GO:0050890|cognition;","GO:0005813|centrosome;GO:0016021|integral component of membrane;GO:0005882|intermediate filament;GO:0042470|melanosome;","GO:0005254|chloride channel activity;GO:0015180|L-alanine transmembrane transporter activity;GO:0015184|L-cystine transmembrane transporter activity;GO:0034590|L-hydroxyproline transmembrane transporter activity;GO:0015193|L-proline transmembrane transporter activity;GO:0015194|L-serine transmembrane transporter activity;GO:0015195|L-threonine transmembrane transporter activity;GO:0015293|symporter activity;","K05615","SLC1A4, SATT; solute carrier family 1 (glutamate/neutral amino acid transporter), member 4"]
["gene14996",79,124,204,123.879041187731,647,343,553,567.322697827642,0.218357280013793,-2.19523746363311,{"v":3.03530875805444e-05,"d":"3.04E-05"},0.00107046222714526,"down","yes","GALNT14","protein_coding","chrNC_037338.1:68772689-68987976:+","gi|300794826|ref|NP_001179661.1|",2673,0,"polypeptide N-acetylgalactosaminyltransferase 14 [Bos taurus]","gi|300794825|ref|NM_001192732.1|",1956,0,"Bos taurus polypeptide N-acetylgalactosaminyltransferase 14 (GALNT14), mRNA","Q96FL9",957,0,"Polypeptide N-acetylgalactosaminyltransferase 14",".",".",".",".","pfam00535","Glycos_transf_2","Glycosyl transferase family 2. Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.","GO:0016266|O-glycan processing;","GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;GO:0004653|polypeptide N-acetylgalactosaminyltransferase activity;","K00710","GALNT; polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]"]
["gene15002",786,869,1737,1023.10680496106,3326,2208,2938,3113.99956655924,0.328550721698244,-1.60581198371943,{"v":3.39732656303702e-05,"d":"3.40E-05"},0.00116922948335355,"down","yes","YPEL5","protein_coding","chrNC_037338.1:69712711-69727353:-","gi|724928464|ref|XP_010382736.1|",686,{"v":3e-82,"d":"3.00E-82"},"PREDICTED: protein yippee-like 5 [Rhinopithecus roxellana]","gi|982939182|ref|XM_005212886.3|",2221,0,"PREDICTED: Bos taurus yippee like 5 (YPEL5), transcript variant X1, mRNA","Q5RDU7",252,{"v":6e-78,"d":"6.00E-78"},"Protein yippee-like 5",".",".",".",".","pfam03226","Yippee-Mis18","Yippee zinc-binding/DNA-binding /Mis18, centromere assembly. This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus.",".",".","GO:0046872|metal ion binding;",".","."]
["gene15032",72,91,87,75.3067639839119,147,231,147,192.781052296366,0.390633638974754,-1.35611190425863,0.0027606682396768,0.0389153288271832,"down","yes","FNDC4","protein_coding","chrNC_037338.1:72189744-72192917:+","gi|946667521|ref|XP_006189797.2|",1197,{"v":5e-159,"d":"5.00E-159"},"PREDICTED: fibronectin type III domain-containing protein 4 [Camelus ferus]","gi|965860945|ref|XM_012145024.2|",1613,0,"PREDICTED: Ovis aries musimon fibronectin type III domain containing 4 (FNDC4), transcript variant X2, mRNA","A6QPL2",462,{"v":1e-159,"d":"1.00E-159"},"Fibronectin type III domain-containing protein 4",".",".",".",".","pfam00041","fn3","Fibronectin type III domain.","GO:0050728|negative regulation of inflammatory response;","GO:0005783|endoplasmic reticulum;GO:0005615|extracellular space;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".",".","."]
["gene15043",5160,5508,6419,5121.29864527516,15035,9446,13315,13892.5218223589,0.368637077613428,-1.43972690997726,{"v":8.22649044021446e-05,"d":"8.23E-05"},0.00247063156578694,"down","yes","TRIM54","protein_coding","chrNC_037338.1:72337035-72358693:-","gi|528969334|ref|XP_005213075.1|",1657,0,"PREDICTED: tripartite motif-containing protein 54 isoform X1 [Bos taurus]","gi|982939367|ref|XM_005213018.3|",1595,0,"PREDICTED: Bos taurus tripartite motif containing 54 (TRIM54), transcript variant X1, mRNA","Q58D15",637,0,"Tripartite motif-containing protein 54",".",".",".",".","pfam13923","zf-C3HC4_2","Zinc finger, C3HC4 type (RING finger).","GO:0007275|multicellular organismal development;GO:0055001|muscle cell development;GO:0007026|negative regulation of microtubule depolymerization;","GO:0005874|microtubule;GO:0005875|microtubule associated complex;GO:0030018|Z disc;","GO:0008017|microtubule binding;GO:0008270|zinc ion binding;","K10653","TRIM54, MURF3; tripartite motif-containing protein 54"]
["gene15222",29,40,33,30.8017949455812,84,92,91,98.0079087718041,0.314278667217543,-1.66988374748494,0.00246142929785753,0.0357067584241694,"down","yes","GRHL1","protein_coding","chrNC_037338.1:87587449-87637671:-","gi|115497798|ref|NP_001069918.1|",3245,0,"grainyhead-like protein 1 homolog [Bos taurus]","gi|115497797|ref|NM_001076450.1|",3498,0,"Bos taurus grainyhead like transcription factor 1 (GRHL1), mRNA","Q9NZI5",1148,0,"Grainyhead-like protein 1 homolog",".",".",".",".","pfam04516","CP2","CP2 transcription factor. This family represents a conserved region in the CP2 transcription factor family.","GO:0002934|desmosome organization;GO:0008544|epidermis development;GO:0061436|establishment of skin barrier;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045616|regulation of keratinocyte differentiation;GO:0019216|regulation of lipid metabolic process;","GO:0005829|cytosol;GO:0005794|Golgi apparatus;GO:0043231|intracellular membrane-bounded organelle;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0031490|chromatin DNA binding;GO:0042803|protein homodimerization activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0044212|transcription regulatory region DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09275","TFCP2; transcription factor CP2 and related proteins"]
["gene15236",401,230,221,247.758865216227,1103,879,1111,1135.8891556872,0.218118875398837,-2.1968134727033,{"v":7.17611543043358e-11,"d":"7.18E-11"},{"v":1.22599849907605e-08,"d":"1.23E-08"},"down","yes","ID2","protein_coding","chrNC_037338.1:88604757-88610166:-","gi|829871493|ref|XP_012641182.1|",706,{"v":4e-86,"d":"4.00E-86"},"PREDICTED: DNA-binding protein inhibitor ID-2 [Microcebus murinus]","gi|942083997|ref|XM_005905515.2|",1690,0,"PREDICTED: Bos mutus inhibitor of DNA binding 2, dominant negative helix-loop-helix protein (ID2), transcript variant X2, mRNA","Q3ZC46",273,{"v":4e-87,"d":"4.00E-87"},"DNA-binding protein inhibitor ID-2",".",".",".",".","pfam00010","HLH","Helix-loop-helix DNA-binding domain.","GO:0060612|adipose tissue development;GO:0008344|adult locomotory behavior;GO:0003166|bundle of His development;GO:0048469|cell maturation;GO:0048667|cell morphogenesis involved in neuron differentiation;GO:0071285|cellular response to lithium ion;GO:0090398|cellular senescence;GO:0032922|circadian regulation of gene expression;GO:0048557|embryonic digestive tract morphogenesis;GO:0061031|endodermal digestive tract morphogenesis;GO:0043153|entrainment of circadian clock by photoperiod;GO:0043353|enucleate erythrocyte differentiation;GO:0061030|epithelial cell differentiation involved in mammary gland alveolus development;GO:0045475|locomotor rhythm;GO:0060749|mammary gland alveolus development;GO:0033598|mammary gland epithelial cell proliferation;GO:0003149|membranous septum morphogenesis;GO:0001656|metanephros development;GO:0001779|natural killer cell differentiation;GO:0045578|negative regulation of B cell differentiation;GO:0043392|negative regulation of DNA binding;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0010629|negative regulation of gene expression;GO:2000178|negative regulation of neural precursor cell proliferation;GO:0045665|negative regulation of neuron differentiation;GO:0048715|negative regulation of oligodendrocyte differentiation;GO:0045668|negative regulation of osteoblast differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0048663|neuron fate commitment;GO:0021772|olfactory bulb development;GO:0014003|oligodendrocyte development;GO:0048541|Peyer's patch development;GO:0048711|positive regulation of astrocyte differentiation;GO:0045777|positive regulation of blood pressure;GO:0071158|positive regulation of cell cycle arrest;GO:0045648|positive regulation of erythrocyte differentiation;GO:0045600|positive regulation of fat cell differentiation;GO:0010628|positive regulation of gene expression;GO:0045651|positive regulation of macrophage differentiation;GO:0048661|positive regulation of smooth muscle cell proliferation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0042752|regulation of circadian rhythm;GO:2000045|regulation of G1/S transition of mitotic cell cycle;GO:0019216|regulation of lipid metabolic process;GO:0001966|thigmotaxis;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0044325|ion channel binding;GO:0046983|protein dimerization activity;","K17693","ID2; DNA-binding protein inhibitor ID2"]
["gene15267",206,163,189,165.152357250865,352,326,347,376.461907528913,0.438696064456882,-1.18870633089175,0.000910172061613239,0.0168078440711245,"down","yes","PTGS1","protein_coding","chrNC_037338.1:93229646-93262108:+","gi|198282107|ref|NP_001098793.1|",2900,0,"prostaglandin G/H synthase 1 precursor [Bos taurus]","gi|198282106|ref|NM_001105323.1|",2480,0,"Bos taurus prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) (PTGS1), mRNA","O62664",1121,0,"Prostaglandin G/H synthase 1",".",".",".",".","pfam03098","An_peroxidase","Animal haem peroxidase.","GO:0019371|cyclooxygenase pathway;GO:0006954|inflammatory response;GO:0008217|regulation of blood pressure;GO:0042127|regulation of cell proliferation;GO:0006979|response to oxidative stress;","GO:0005789|endoplasmic reticulum membrane;GO:0005794|Golgi apparatus;GO:0031090|organelle membrane;GO:0001750|photoreceptor outer segment;","GO:0051213|dioxygenase activity;GO:0020037|heme binding;GO:0046872|metal ion binding;GO:0004601|peroxidase activity;GO:0004666|prostaglandin-endoperoxide synthase activity;","K00509","PTGS1, COX1; prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1]"]
["gene15369",508,399,576,440.058019274492,1746,543,1256,1305.25528332135,0.337143258408976,-1.56856634538147,0.000613179169986478,0.0124339835812965,"down","yes","ZBTB43","protein_coding","chrNC_037338.1:97584362-97613165:+","gi|66792714|ref|NP_001019674.1|",2633,0,"zinc finger and BTB domain-containing protein 43 [Bos taurus]","gi|982939613|ref|XM_010810328.2|",5612,0,"PREDICTED: Bos taurus zinc finger and BTB domain containing 43 (ZBTB43), transcript variant X1, mRNA","O43298",920,0,"Zinc finger and BTB domain-containing protein 43",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K10514","ZBTB43; zinc finger and BTB domain-containing protein 43"]
["gene1561",1799,506,1486,1091.06909628852,9486,1754,6681,6600.9201672574,0.165290454761225,-2.5969246810028,{"v":5.48076149385327e-05,"d":"5.48E-05"},0.00175698433911379,"down","yes","ZNF385B","protein_coding","chrNC_037329.1:16957646-17442243:+","gi|528938767|ref|XP_005202329.1|",2058,0,"PREDICTED: zinc finger protein 385B isoform X2 [Bos taurus]","gi|742201733|ref|XM_010859745.1|",2931,0,"PREDICTED: Bison bison bison zinc finger protein 385B (ZNF385B), mRNA","Q569K4",713,0,"Zinc finger protein 385B",".",".",".",".","pfam12874","zf-met","Zinc-finger of C2H2 type. This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.","GO:0072332|intrinsic apoptotic signaling pathway by p53 class mediator;","GO:0001650|fibrillar center;GO:0005634|nucleus;","GO:0002039|p53 binding;GO:0003723|RNA binding;GO:0008270|zinc ion binding;",".","."]
["gene15875",109,21,232,106.542223075565,4097,327,2572,2579.75506964876,0.0412993560237759,-4.59773690373649,0.000376268265893612,0.00840921896053349,"down","yes","POSTN","protein_coding","chrNC_037339.1:24219116-24254425:+","gi|528970766|ref|XP_005213601.1|",4144,0,"PREDICTED: periostin isoform X1 [Bos taurus]","gi|741945117|ref|XM_005213544.2|",3643,0,"PREDICTED: Bos taurus periostin, osteoblast specific factor (POSTN), transcript variant X1, mRNA","Q15063",1517,0,"Periostin","all4647",81.6,{"v":2e-16,"d":"2.00E-16"},"COG2335","pfam02469","Fasciclin","Fasciclin domain. This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.","GO:1990523|bone regeneration;GO:0007155|cell adhesion;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0071307|cellular response to vitamin K;GO:0030198|extracellular matrix organization;GO:0001953|negative regulation of cell-matrix adhesion;GO:1900025|negative regulation of substrate adhesion-dependent cell spreading;GO:1990138|neuron projection extension;GO:1904209|positive regulation of chemokine (C-C motif) ligand 2 secretion;GO:0014911|positive regulation of smooth muscle cell migration;GO:0008593|regulation of Notch signaling pathway;GO:0003073|regulation of systemic arterial blood pressure;GO:0032355|response to estradiol;GO:0001666|response to hypoxia;GO:0009612|response to mechanical stimulus;GO:0014850|response to muscle activity;GO:0001501|skeletal system development;","GO:0031012|extracellular matrix;GO:0005615|extracellular space;GO:0031594|neuromuscular junction;GO:0005802|trans-Golgi network;","GO:0008201|heparin binding;GO:0046872|metal ion binding;",".","."]
["gene15883",35,44,51,39.2045944883706,672,139,447,463.538309832374,0.0845768163208514,-3.56359393497156,{"v":8.84527808280282e-10,"d":"8.85E-10"},{"v":1.18481046469694e-07,"d":"1.18E-07"},"down","yes","SMAD9","protein_coding","chrNC_037339.1:24731865-24798685:+","gi|555989982|ref|XP_005906815.1|",2014,0,"PREDICTED: mothers against decapentaplegic homolog 9 isoform X1 [Bos mutus]","gi|982940653|ref|XM_005213671.3|",4960,0,"PREDICTED: Bos taurus SMAD family member 9 (SMAD9), transcript variant X1, mRNA","Q9JIW5",774,0,"Mothers against decapentaplegic homolog 9",".",".",".",".","pfam03166","MH2","MH2 domain. This is the MH2 (MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C-terminus of MH2.","GO:0030509|BMP signaling pathway;GO:0060348|bone development;GO:0051216|cartilage development;GO:0071407|cellular response to organic cyclic compound;GO:0030902|hindbrain development;GO:0030901|midbrain development;GO:0001880|Mullerian duct regression;GO:0045597|positive regulation of cell differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0006468|protein phosphorylation;GO:0060395|SMAD protein signal transduction;GO:0006351|transcription, DNA-templated;GO:0007179|transforming growth factor beta receptor signaling pathway;GO:0001657|ureteric bud development;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;","K16791","SMAD9, SMAD8; mothers against decapentaplegic homolog 9"]
["gene15980",152,5,3,42.1746852959614,330,200,283,298.896310991168,0.141101391168416,-2.82519588284246,{"v":3.81546914996518e-05,"d":"3.82E-05"},0.00128980035921394,"down","yes","ATP8A2","protein_coding","chrNC_037339.1:33375501-33873439:-","gi|373938472|ref|NP_001157274.3|",5999,0,"phospholipid-transporting ATPase IB [Bos taurus]","gi|965844485|ref|XM_012137228.2|",4163,0,"PREDICTED: Ovis aries musimon phospholipid-transporting ATPase IB (LOC101115632), transcript variant X4, mRNA","C7EXK4",2264,0,"Phospholipid-transporting ATPase IB",".",".",".",".","pfam13246","Hydrolase_like2","Putative hydrolase of sodium-potassium ATPase alpha subunit. This is a putative hydrolase of the sodium-potassium ATPase alpha subunit.","GO:0048666|neuron development;","GO:0005768|endosome;GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;GO:0097381|photoreceptor disc membrane;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004012|phospholipid-translocating ATPase activity;","K14802","DRS2, ATP8A; phospholipid-transporting ATPase [EC:3.6.3.1]"]
["gene16000",76,47,83,60.7011925117343,234,134,197,207.749726373137,0.292184223639888,-1.77504981233443,0.000190285887939536,0.00486013646795884,"down","yes","FGF9","protein_coding","chrNC_037339.1:35379638-35405463:-","gi|350539874|ref|NP_001232855.1|",1101,{"v":1e-150,"d":"1.00E-150"},"fibroblast growth factor 9 [Bos taurus]","gi|982991956|ref|XM_015465704.1|",697,0,"PREDICTED: Bos taurus fibroblast growth factor 9 (LOC104973585), mRNA","P31371",424,{"v":2e-150,"d":"2.00E-150"},"Fibroblast growth factor 9",".",".",".",".","pfam00167","FGF","Fibroblast growth factor. Fibroblast growth factors are a family of proteins involved in growth and differentiation in a wide range of contexts. They are found in a wide range of organisms, from nematodes to humans. Most share an internal core region of high similarity, conserved residues in which are involved in binding with their receptors. On binding, they cause dimerization of their tyrosine kinase receptors leading to intracellular signalling. There are currently four known tyrosine kinase receptors for fibroblast growth factors. These receptors can each bind several different members of this family. Members of this family have a beta trefoil structure. Most have N-terminal signal peptides and are secreted. A few lack signal sequences but are secreted anyway; still others also lack the signal peptide but are found on the cell surface and within the extracellular matrix. A third group remain intracellular. They have central roles in development, regulating cell proliferation, migration and differentiation. On the other hand, they are important in tissue repair following injury in adult organisms.","GO:0001525|angiogenesis;GO:0007267|cell-cell signaling;GO:0002062|chondrocyte differentiation;GO:0048566|embryonic digestive tract development;GO:0030326|embryonic limb morphogenesis;GO:0048706|embryonic skeletal system development;GO:0001654|eye development;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:0042472|inner ear morphogenesis;GO:0060484|lung-associated mesenchyme development;GO:0008584|male gonad development;GO:0030238|male sex determination;GO:0000165|MAPK cascade;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030178|negative regulation of Wnt signaling pathway;GO:0001649|osteoblast differentiation;GO:0032927|positive regulation of activin receptor signaling pathway;GO:0090263|positive regulation of canonical Wnt signaling pathway;GO:0060045|positive regulation of cardiac muscle cell proliferation;GO:0051781|positive regulation of cell division;GO:0008284|positive regulation of cell proliferation;GO:0050679|positive regulation of epithelial cell proliferation;GO:0010628|positive regulation of gene expression;GO:0043410|positive regulation of MAPK cascade;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0051897|positive regulation of protein kinase B signaling;GO:0045880|positive regulation of smoothened signaling pathway;GO:0030949|positive regulation of vascular endothelial growth factor receptor signaling pathway;GO:1904707|positive regulation of vascular smooth muscle cell proliferation;GO:0006606|protein import into nucleus;GO:0048505|regulation of timing of cell differentiation;GO:0007165|signal transduction;GO:0021762|substantia nigra development;","GO:0005604|basement membrane;GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0016303|1-phosphatidylinositol-3-kinase activity;GO:0005104|fibroblast growth factor receptor binding;GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0004713|protein tyrosine kinase activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;","K04358","FGF; fibroblast growth factor"]
["gene16070",488,902,1264,810.987231101058,2406,1852,2179,2365.5069266929,0.342838662592656,-1.54439828069523,{"v":3.5609309289038e-06,"d":"3.56E-06"},0.000175773218568433,"down","yes","UCHL3","protein_coding","chrNC_037339.1:50599657-50648829:+","gi|926706055|ref|XP_005687718.2|",1360,0,"PREDICTED: ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform X1 [Capra hircus]","gi|982941282|ref|XM_010810845.2|",1050,0,"PREDICTED: Bos taurus ubiquitin C-terminal hydrolase L3 (UCHL3), transcript variant X2, mRNA","Q2TBG8",313,{"v":8e-104,"d":"8.00E-104"},"Ubiquitin carboxyl-terminal hydrolase isozyme L3",".",".",".",".","pfam01088","Peptidase_C12","Ubiquitin carboxyl-terminal hydrolase, family 1.","GO:0016579|protein deubiquitination;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0004843|ubiquitin-specific protease activity;GO:0043130|ubiquitin binding;","K05609","UCHL3, YUH1; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"]
["gene16142",34,16,32,23.9325651951959,69,91,82,88.7856438539622,0.269554447727619,-1.89135138022971,0.00149731349185269,0.0248371228116564,"down","yes","GPC6","protein_coding","chrNC_037339.1:67701756-68210207:+","gi|126165278|ref|NP_001075199.1|",755,{"v":7e-93,"d":"7.00E-93"},"glypican-6 precursor [Bos taurus]","gi|126165277|ref|NM_001081730.1|",2060,0,"Bos taurus glypican 6 (GPC6), mRNA","Q5RE54",195,{"v":2e-52,"d":"2.00E-52"},"Glypican-6",".",".",".",".","pfam01153","Glypican","Glypican.","GO:0016477|cell migration;GO:0009966|regulation of signal transduction;","GO:0046658|anchored component of plasma membrane;GO:0005615|extracellular space;","GO:0043395|heparan sulfate proteoglycan binding;","K08112","GPC6; glypican 6"]
["gene162",56,39,33,37.5109046609523,104,91,102,109.086984779498,0.34386232910163,-1.54009702088106,0.00367959765535576,0.0480030181549864,"down","yes","CXADR","protein_coding","chrNC_037328.1:19437777-19502842:-","gi|803228500|ref|XP_011974521.1|",1885,0,"PREDICTED: coxsackievirus and adenovirus receptor isoform X5 [Ovis aries musimon]","gi|402745661|ref|NM_174298.4|",2077,0,"Bos taurus coxsackie virus and adenovirus receptor (CXADR), mRNA","Q8WMV3",665,0,"Coxsackievirus and adenovirus receptor homolog",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.","GO:0031532|actin cytoskeleton reorganization;GO:0086067|AV node cell to bundle of His cell communication;GO:0086072|AV node cell-bundle of His cell adhesion involved in cell communication;GO:0048739|cardiac muscle fiber development;GO:0045216|cell-cell junction organization;GO:0010669|epithelial structure maintenance;GO:0046629|gamma-delta T cell activation;GO:0008354|germ cell migration;GO:0007507|heart development;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0034109|homotypic cell-cell adhesion;GO:0007005|mitochondrion organization;GO:0060044|negative regulation of cardiac muscle cell proliferation;GO:0030593|neutrophil chemotaxis;GO:0098904|regulation of AV node cell action potential;","GO:0001669|acrosomal vesicle;GO:0005912|adherens junction;GO:0016327|apicolateral plasma membrane;GO:0016323|basolateral plasma membrane;GO:0005923|bicellular tight junction;GO:0044297|cell body;GO:0005737|cytoplasm;GO:0030175|filopodium;GO:0030426|growth cone;GO:0016021|integral component of membrane;GO:0014704|intercalated disc;GO:0045121|membrane raft;GO:0043005|neuron projection;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0008013|beta-catenin binding;GO:0050839|cell adhesion molecule binding;GO:0071253|connexin binding;GO:0030165|PDZ domain binding;","K06788","CXADR, CAR; coxsackievirus and adenovirus receptor"]
["gene16327",793,2374,1933,1578.34211501203,7829,2640,6318,6175.70426943717,0.255572813423573,-1.96819371722934,0.0024018508637396,0.03517823767626,"down","yes","TMCO3","protein_coding","chrNC_037339.1:86682932-86704834:+","gi|148228635|ref|NP_001091472.1|",3007,0,"transmembrane and coiled-coil domain-containing protein 3 precursor [Bos taurus]","gi|982941906|ref|XM_005213985.3|",2917,0,"PREDICTED: Bos taurus transmembrane and coiled-coil domains 3 (TMCO3), transcript variant X1, mRNA","Q8BH01",979,0,"Transmembrane and coiled-coil domain-containing protein 3","alr2046_1",133,{"v":3e-32,"d":"3.00E-32"},"COG0475","pfam00999","Na_H_Exchanger","Sodium/hydrogen exchanger family. Na/H antiporters are key transporters in maintaining the pH of actively metabolizing cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.",".","GO:0016021|integral component of membrane;GO:0016020|membrane;","GO:0022890|inorganic cation transmembrane transporter activity;GO:0015299|solute:proton antiporter activity;",".","."]
["gene16377",18,40,7,19.9497768665722,103,51,95,91.5069037105627,0.218013899035132,-2.19750798084912,0.00225716000345241,0.0335761376738794,"down","yes","ANKEF1","protein_coding","chrNC_037340.1:3252146-3279756:+","gi|594074801|ref|XP_006061187.1|",3899,0,"PREDICTED: ankyrin repeat and EF-hand domain-containing protein 1-like isoform X1 [Bubalus bubalis]","gi|982992459|ref|XM_001255789.4|",2782,0,"PREDICTED: Bos taurus ankyrin repeat and EF-hand domain containing 1 (ANKEF1), transcript variant X1, mRNA","Q9NU02",1322,0,"Ankyrin repeat and EF-hand domain-containing protein 1","DRA0257",82.8,{"v":1e-16,"d":"1.00E-16"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".","GO:0005509|calcium ion binding;",".","."]
["gene16429",411,316,515,368.842578277138,838,629,860,854.489524539081,0.431652545390881,-1.21205759901268,{"v":9.29502706517339e-05,"d":"9.30E-05"},0.00275100017838654,"down","yes","CCDC3","protein_coding","chrNC_037340.1:11479616-11570661:+","gi|288869478|ref|NP_001165846.1|",1352,{"v":6e-178,"d":"6.00E-178"},"coiled-coil domain-containing protein 3 precursor [Bos taurus]","gi|288869477|ref|NM_001172375.1|",2599,0,"Bos taurus coiled-coil domain containing 3 (CCDC3), mRNA","Q9D6Y1",472,{"v":6e-159,"d":"6.00E-159"},"Coiled-coil domain-containing protein 3",".",".",".",".","pfam07321","YscO","Type III secretion protein YscO. This family contains the bacterial type III secretion protein YscO, which is approximately 150 residues long. YscO has been shown to be required for high-level expression and secretion of the anti-host proteins V antigen and Yops in Yersinia pestis.","GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0045600|positive regulation of fat cell differentiation;GO:0046889|positive regulation of lipid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005576|extracellular region;",".",".","."]
["gene1648",160,51,116,94.0394290318698,169,353,234,277.181074992578,0.339270742183202,-1.5594910737014,0.00276479280606947,0.0389349968163712,"down","yes","RAPGEF4","protein_coding","chrNC_037329.1:23607682-23937899:-","gi|965808735|ref|XP_014958578.1|",5258,0,"PREDICTED: rap guanine nucleotide exchange factor 4 isoform X8 [Ovis aries musimon]","gi|982913239|ref|XM_015474949.1|",4162,0,"PREDICTED: Bos taurus Rap guanine nucleotide exchange factor 4 (RAPGEF4), transcript variant X8, mRNA","Q8WZA2",1981,0,"Rap guanine nucleotide exchange factor 4",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0017156|calcium ion-dependent exocytosis;GO:0019933|cAMP-mediated signaling;GO:0007186|G-protein coupled receptor signaling pathway;GO:0030073|insulin secretion;GO:0017157|regulation of exocytosis;GO:0050796|regulation of insulin secretion;GO:0007264|small GTPase mediated signal transduction;","GO:0005829|cytosol;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0030552|cAMP binding;GO:0005085|guanyl-nucleotide exchange factor activity;GO:0017016|Ras GTPase binding;GO:0005088|Ras guanyl-nucleotide exchange factor activity;","K04351","RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4"]
["gene16515",2543,1318,1730,1626.01721861079,3653,2479,3115,3399.56756450206,0.47830119206616,-1.06400870794157,0.000803978565876667,0.0153433528180784,"down","yes","PLXDC2","protein_coding","chrNC_037340.1:21311488-21742391:+","gi|528972545|ref|XP_005214246.1|",2573,0,"PREDICTED: plexin domain-containing protein 2 isoform X1 [Bos taurus]","gi|850488330|gb|CP011898.1|",5159,0,"Ovis canadensis canadensis isolate 43U chromosome 13 sequence","Q6UX71",936,0,"Plexin domain-containing protein 2",".",".",".",".","pfam01437","PSI","Plexin repeat. A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas shows 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).",".","GO:0016021|integral component of membrane;",".",".","."]
["gene16548",5505,2820,3830,3535.17063086496,10592,5586,9034,9269.97324589991,0.381357155742446,-1.39078532430937,0.000825508593176602,0.0156391671128298,"down","yes","KIAA1217","protein_coding","chrNC_037340.1:24591905-25412646:+","gi|982992657|ref|XP_015321397.1|",7444,0,"PREDICTED: sickle tail protein homolog isoform X2 [Bos taurus]","gi|982992694|ref|XM_015465931.1|",8069,0,"PREDICTED: Bos taurus KIAA1217 ortholog (KIAA1217), transcript variant X21, mRNA","Q5T5P2",2141,0,"Sickle tail protein homolog",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.","GO:0048706|embryonic skeletal system development;","GO:0005737|cytoplasm;",".",".","."]
["gene16569",289,276,363,277.255347906425,1756,941,1435,1519.66816371413,0.18244466425407,-2.45446913616422,{"v":3.84015232396048e-09,"d":"3.84E-09"},{"v":4.43576461355937e-07,"d":"4.44E-07"},"down","yes","MCM10","protein_coding","chrNC_037340.1:27854539-27891323:+","gi|528913248|ref|XP_005194353.1|",4302,0,"PREDICTED: protein MCM10 homolog isoform X1 [Bos taurus]","gi|528913249|ref|XM_005194297.1|",4463,0,"PREDICTED: Bos taurus minichromosome maintenance 10 replication initiation factor (MCM10), transcript variant X3, mRNA","Q7L590",1368,0,"Protein MCM10 homolog",".",".",".",".","pfam09332","Mcm10","Mcm10 replication factor. Mcm10 is a eukaryotic DNA replication factor that regulates the stability and chromatin association of DNA polymerase alpha.","GO:0008283|cell proliferation;GO:0006974|cellular response to DNA damage stimulus;GO:0006260|DNA replication;GO:0006270|DNA replication initiation;GO:0000082|G1/S transition of mitotic cell cycle;","GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0031298|replication fork protection complex;","GO:0003688|DNA replication origin binding;GO:0019899|enzyme binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0003697|single-stranded DNA binding;","K10736","MCM10; minichromosome maintenance protein 10"]
["gene16597",279,227,372,261.355043959413,1044,753,881,984.572640329376,0.265450240291036,-1.91348664746779,{"v":6.91397875257392e-09,"d":"6.91E-09"},{"v":7.41589202216867e-07,"d":"7.42E-07"},"down","yes","NMT2","protein_coding","chrNC_037340.1:29681995-29742423:-","gi|86825101|gb|AAI12452.1|",1990,0,"NMT2 protein [Bos taurus]","gi|86825100|gb|BC112451.1|",2916,0,"Bos taurus N-myristoyltransferase 2, mRNA (cDNA clone MGC:134515 IMAGE:8065759), complete cds","Q9N181",759,0,"Glycylpeptide N-tetradecanoyltransferase 2","SPBC2G2.11",283,{"v":2e-90,"d":"2.00E-90"},"COG5092","pfam01233","NMT","Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain. The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.","GO:0018008|N-terminal peptidyl-glycine N-myristoylation;","GO:0005737|cytoplasm;GO:0016020|membrane;","GO:0004379|glycylpeptide N-tetradecanoyltransferase activity;","K00671","E2.3.1.97, NMT; glycylpeptide N-tetradecanoyltransferase [EC:2.3.1.97]"]
["gene16604",3,0,11,4.16020768019775,54,25,76,56.7921056171662,0.0732532741124546,-3.77096294641405,0.00369995677367154,0.0481704868127699,"down","yes","C1QL3","protein_coding","chrNC_037340.1:30996656-31004164:-","gi|466052462|ref|XP_004278652.1|",958,{"v":5e-123,"d":"5.00E-123"},"PREDICTED: complement C1q-like protein 3 [Orcinus orca]","gi|329663905|ref|NM_001206164.1|",1708,0,"Bos taurus complement component 1, q subcomponent-like 3 (C1QL3), mRNA","Q9ESN4",372,{"v":6e-124,"d":"6.00E-124"},"Complement C1q-like protein 3",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0050807|regulation of synapse organization;","GO:0005581|collagen trimer;GO:0005576|extracellular region;","GO:0042802|identical protein binding;",".","."]
["gene16606",68,18,48,38.3631367437699,56,306,138,183.043467767671,0.209584844581629,-2.25439369784711,0.0011688978455058,0.0204134211176303,"down","yes","CUBN","protein_coding","chrNC_037340.1:31276403-31535596:-","gi|300796839|ref|NP_001179504.1|",19126,0,"cubilin precursor [Bos taurus]","gi|300796838|ref|NM_001192575.1|",11210,0,"Bos taurus cubilin (CUBN), mRNA","Q9TU53",6202,0,"Cubilin",".",".",".",".","pfam00431","CUB","CUB domain.","GO:0008203|cholesterol metabolic process;GO:0015031|protein transport;","GO:0016324|apical plasma membrane;GO:0031526|brush border membrane;GO:0010008|endosome membrane;GO:0005765|lysosomal membrane;","GO:0005509|calcium ion binding;GO:0031419|cobalamin binding;GO:0008144|drug binding;","K14616","CUBN; cubilin"]
["gene16623",1204,726,723,773.762353353442,1633,1307,1453,1614.50965086368,0.479255328662494,-1.06113362211294,0.000281031045454313,0.00664850477434245,"down","yes","ARHGAP12","protein_coding","chrNC_037340.1:33421095-33539282:+","gi|741946950|ref|XP_010809440.1|",4322,0,"PREDICTED: rho GTPase-activating protein 12 isoform X1 [Bos taurus]","gi|982942292|ref|XM_010811138.2|",5130,0,"PREDICTED: Bos taurus Rho GTPase activating protein 12 (ARHGAP12), transcript variant X1, mRNA","Q9BE31",1462,0,"Rho GTPase-activating protein 12",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0007015|actin filament organization;GO:0051058|negative regulation of small GTPase mediated signal transduction;GO:0006911|phagocytosis, engulfment;GO:0007165|signal transduction;","GO:0001891|phagocytic cup;","GO:0005096|GTPase activator activity;",".","."]
["gene16704",818,386,663,543.310474987937,1439,815,1168,1258.56348421583,0.431690957033014,-1.21192922302908,0.00198989276985302,0.0306995103487502,"down","yes","RALGAPA2","protein_coding","chrNC_037340.1:39911680-40188457:-","gi|982942616|ref|XP_015329529.1|",9841,0,"PREDICTED: ral GTPase-activating protein subunit alpha-2 isoform X1 [Bos taurus]","gi|982942615|ref|XM_015474043.1|",7401,0,"PREDICTED: Bos taurus Ral GTPase activating protein, alpha subunit 2 (catalytic) (RALGAPA2), transcript variant X1, mRNA","Q2PPJ7",3249,0,"Ral GTPase-activating protein subunit alpha-2",".",".",".",".","pfam02145","Rap_GAP","Rap/ran-GAP.","GO:0090630|activation of GTPase activity;GO:0051056|regulation of small GTPase mediated signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005615|extracellular space;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005096|GTPase activator activity;GO:0046982|protein heterodimerization activity;",".","."]
["gene17043",10,26,16,16.0408381654631,55,229,103,141.777605769435,0.113140845328911,-3.14380823969392,{"v":2.15446411663983e-05,"d":"2.15E-05"},0.000809868454701594,"down","yes","PCK1","protein_coding","chrNC_037340.1:58609020-58615146:-","gi|296481011|tpg|DAA23126.1|",3272,0,"TPA: phosphoenolpyruvate carboxykinase, cytosolic [Bos taurus]","gi|86438116|gb|BC112664.1|",2563,0,"Bos taurus phosphoenolpyruvate carboxykinase 1 (soluble), mRNA (cDNA clone MGC:137419 IMAGE:8026883), complete cds","Q8HYZ4",1230,0,"Phosphoenolpyruvate carboxykinase, cytosolic [GTP]","CPn0851",621,0,"COG1274","pfam00821","PEPCK","Phosphoenolpyruvate carboxykinase. Catalyses the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate.","GO:0006094|gluconeogenesis;GO:0006475|internal protein amino acid acetylation;","GO:0005737|cytoplasm;","GO:0005525|GTP binding;GO:0046872|metal ion binding;GO:0004613|phosphoenolpyruvate carboxykinase (GTP) activity;","K01596","E4.1.1.32, pckA, PEPCK; phosphoenolpyruvate carboxykinase (GTP) [EC:4.1.1.32]"]
["gene17082",143,86,149,111.213966686952,762,363,616,640.387071551247,0.173666789395906,-2.52560620356075,{"v":1.44820289847045e-07,"d":"1.45E-07"},{"v":1.15415298592906e-05,"d":"1.15E-05"},"down","yes","SRXN1","protein_coding","chrNC_037340.1:60403292-60410158:+","gi|329664542|ref|NP_001192917.1|",611,{"v":6e-71,"d":"6.00E-71"},"sulfiredoxin-1 [Bos taurus]","gi|329664541|ref|NM_001205988.1|",2538,0,"Bos taurus sulfiredoxin 1 (SRXN1), mRNA","Q9BYN0",225,{"v":3e-67,"d":"3.00E-67"},"Sulfiredoxin-1","SPBC106.02c",81.3,{"v":9e-17,"d":"9.00E-17"},"COG5119","pfam02195","ParBc","ParB-like nuclease domain.","GO:0034599|cellular response to oxidative stress;GO:0006979|response to oxidative stress;","GO:0005829|cytosol;","GO:0005524|ATP binding;GO:0016667|oxidoreductase activity, acting on a sulfur group of donors;GO:0032542|sulfiredoxin activity;","K12260","SRX1; sulfiredoxin [EC:1.8.98.2]"]
["gene1710",61,35,64,47.0239207701581,121,109,131,132.515032319595,0.354857256169605,-1.49468928782001,0.00246794308097776,0.0357789044935856,"down","yes","CERS6","protein_coding","chrNC_037329.1:27353327-27712377:-","gi|594072375|ref|XP_006060021.1|",1874,0,"PREDICTED: ceramide synthase 6 isoform X1 [Bubalus bubalis]","gi|742198339|ref|XM_010858928.1|",5503,0,"PREDICTED: Bison bison bison ceramide synthase 6 (CERS6), transcript variant X2, mRNA","Q6ZMG9",665,0,"Ceramide synthase 6","ECU08g1350",114,{"v":8e-26,"d":"8.00E-26"},"COG5058","pfam03798","TRAM_LAG1_CLN8","TLC domain.","GO:0046513|ceramide biosynthetic process;GO:0030148|sphingolipid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0031965|nuclear membrane;","GO:0003677|DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0050291|sphingosine N-acyltransferase activity;","K04710","CERS; ceramide synthetase [EC:2.3.1.24]"]
["gene17253",13,17,17,14.1803703967205,19,210,100,120.26627204662,0.11790812299581,-3.08426498214994,{"v":9.92803694385254e-05,"d":"9.93E-05"},0.00287862624029529,"down","yes","NNAT","protein_coding","chrNC_037340.1:66465154-66467548:+","gi|426242021|ref|XP_004014877.1|",651,{"v":2e-97,"d":"2.00E-97"},"PREDICTED: neuronatin isoform X1 [Ovis aries]","gi|318043189|ref|NM_001201324.1|",1261,0,"Bos taurus neuronatin (NNAT), transcript variant 1, mRNA","Q0Q043",153,{"v":1e-43,"d":"1.00E-43"},"Neuronatin",".",".",".",".","pfam05287","PMG","PMG protein. This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteristic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.","GO:0007420|brain development;GO:0032024|positive regulation of insulin secretion;","GO:0005737|cytoplasm;",".",".","."]
["gene17261",24,3,1,7.54523235529695,66,43,70,65.7172616104754,0.114813553857731,-3.12263513119171,0.00265178493130867,0.0377158902667834,"down","yes","KIAA1755","protein_coding","chrNC_037340.1:67088089-67126765:-","gi|528974582|ref|XP_003586864.2|",5909,0,"PREDICTED: uncharacterized protein KIAA1755 homolog [Bos taurus]","gi|982993737|ref|XM_003582983.4|",4409,0,"PREDICTED: Bos taurus KIAA1755 ortholog (KIAA1755), mRNA",".",".",".",".",".",".",".",".","pfam13716","CRAL_TRIO_2","Divergent CRAL/TRIO domain. This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.",".",".",".",".","."]
["gene17264",7,4,32,12.9631256501391,82,88,78,91.0997747655844,0.142295913282941,-2.81303386641086,0.000842263715063137,0.0158722761258034,"down","yes","LBP","protein_coding","chrNC_037340.1:67214890-67247278:+","gi|284391862|emb|CBI83120.1|",2402,0,"lipopolysaccharide binding protein [Bubalus bubalis]","gi|402692822|ref|NM_001038674.2|",1794,0,"Bos taurus lipopolysaccharide binding protein (LBP), mRNA","Q2TBI0",898,0,"Lipopolysaccharide-binding protein",".",".",".",".","pfam02886","LBP_BPI_CETP_C","LBP / BPI / CETP family, C-terminal domain. The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.","GO:0006953|acute-phase response;GO:0071222|cellular response to lipopolysaccharide;GO:0050829|defense response to Gram-negative bacterium;GO:0045087|innate immune response;GO:0006869|lipid transport;GO:0002281|macrophage activation involved in immune response;GO:0032760|positive regulation of tumor necrosis factor production;","GO:0005615|extracellular space;GO:0016020|membrane;","GO:0001530|lipopolysaccharide binding;","K05399","LBP; lipopolysaccharide-binding protein"]
["gene17277",2,29,22,16.7817351100418,89,71,107,97.9455764892021,0.171337345815631,-2.54508844988277,0.000291262592173076,0.00683951688665846,"down","yes","ADIG","protein_coding","chrNC_037340.1:67456834-67466702:+","gi|635020938|ref|XP_008015788.1|",289,{"v":7e-28,"d":"7.00E-28"},"PREDICTED: adipogenin isoform X2 [Chlorocebus sabaeus]","gi|982943010|ref|XM_015474139.1|",961,0,"PREDICTED: Bos taurus adipogenin (ADIG), transcript variant X2, mRNA","Q2EMW0",109,{"v":8e-28,"d":"8.00E-28"},"Adipogenin",".",".",".",".","pfam15202","Adipogenin","Adipogenin. This family of proteins is involved in the stimulation of adipocyte differentiation and development.","GO:0050873|brown fat cell differentiation;GO:0045600|positive regulation of fat cell differentiation;GO:0007283|spermatogenesis;GO:0050872|white fat cell differentiation;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005811|lipid particle;GO:0005634|nucleus;",".",".","."]
["gene17278",0,1,2,0.941960946422795,36,16,36,32.3224763348036,0.0291425983784703,-5.10072667473978,{"v":2.81415679220438e-05,"d":"2.81E-05"},0.00100488995542407,"down","yes","ARHGAP40","protein_coding","chrNC_037340.1:67470695-67474808:+","gi|675783417|ref|XP_008949521.1|",205,{"v":2e-13,"d":"2.00E-13"},"PREDICTED: rho GTPase-activating protein 40 isoform X2 [Pan paniscus]","gi|803137484|ref|XR_001044722.1|",1495,0,"PREDICTED: Ovis aries uncharacterized LOC105606885 (LOC105606885), ncRNA","Q5TG30",83.2,{"v":8e-15,"d":"8.00E-15"},"Rho GTPase-activating protein 40",".",".",".",".","pfam11969","DcpS_C","Scavenger mRNA decapping enzyme C-term binding. This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.","GO:0051056|regulation of small GTPase mediated signal transduction;GO:0007165|signal transduction;","GO:0005829|cytosol;","GO:0005096|GTPase activator activity;",".","."]
["gene17654",88,83,99,80.5404539429358,698,127,571,513.61306751751,0.156811535836147,-2.67289639971084,{"v":1.12812601764513e-06,"d":"1.13E-06"},{"v":6.79437328242218e-05,"d":"6.79E-05"},"down","yes","ADGRB1","protein_coding","chrNC_037341.1:1797345-1874927:-","gi|741949430|ref|XP_010810156.1|",7446,0,"PREDICTED: brain-specific angiogenesis inhibitor 1 isoform X1 [Bos taurus]","gi|982944124|ref|XM_010811854.2|",5621,0,"PREDICTED: Bos taurus adhesion G protein-coupled receptor B1 (ADGRB1), transcript variant X1, mRNA","O14514",2706,0,"Adhesion G protein-coupled receptor B1",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0043277|apoptotic cell clearance;GO:0007409|axonogenesis;GO:0007155|cell adhesion;GO:0007166|cell surface receptor signaling pathway;GO:0050829|defense response to Gram-negative bacterium;GO:0043652|engulfment of apoptotic cell;GO:0007186|G-protein coupled receptor signaling pathway;GO:0045087|innate immune response;GO:0007517|muscle organ development;GO:0016525|negative regulation of angiogenesis;GO:0008285|negative regulation of cell proliferation;GO:0010596|negative regulation of endothelial cell migration;GO:0042177|negative regulation of protein catabolic process;GO:0031397|negative regulation of protein ubiquitination;GO:0007422|peripheral nervous system development;GO:0006910|phagocytosis, recognition;GO:1901741|positive regulation of myoblast fusion;GO:1903428|positive regulation of reactive oxygen species biosynthetic process;GO:0051965|positive regulation of synapse assembly;GO:0048167|regulation of synaptic plasticity;GO:0007165|signal transduction;","GO:0005911|cell-cell junction;GO:0030425|dendrite;GO:0043197|dendritic spine;GO:0005615|extracellular space;GO:0005925|focal adhesion;GO:0016021|integral component of membrane;GO:0005887|integral component of plasma membrane;GO:0048471|perinuclear region of cytoplasm;GO:0001891|phagocytic cup;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;","GO:0004930|G-protein coupled receptor activity;GO:0001530|lipopolysaccharide binding;GO:0030165|PDZ domain binding;GO:0001786|phosphatidylserine binding;","K04596","BAI1; brain-specific angiogenesis inhibitor 1"]
["gene17682",337,18,16,98.6428951772515,647,346,518,555.789609438747,0.177482438501979,-2.49425181471809,0.0015428312191165,0.0254884293645703,"down","yes","COL22A1","protein_coding","chrNC_037341.1:4095051-4319199:+","gi|528975450|ref|XP_002692646.2|",2579,0,"PREDICTED: collagen alpha-1(XXII) chain isoform X1 [Bos taurus]","gi|982994244|ref|XM_010822664.2|",6326,0,"PREDICTED: Bos taurus collagen type XXII alpha 1 (COL22A1), transcript variant X1, mRNA","Q8NFW1",858,0,"Collagen alpha-1(XXII) chain",".",".",".",".","pfam00092","VWA","von Willebrand factor type A domain.",".","GO:0005581|collagen trimer;GO:0005788|endoplasmic reticulum lumen;GO:0005576|extracellular region;",".","K16630","COL22A; collagen, type XXII, alpha"]
["gene17704",37,13,5,15.438997760666,363,37,254,240.943470456846,0.0640772614895625,-3.9640436980807,0.000244083831757682,0.00590165746091391,"down","yes","WISP1","protein_coding","chrNC_037341.1:8137191-8169250:-","gi|528975502|ref|XP_005215377.1|",1560,0,"PREDICTED: WNT1-inducible-signaling pathway protein 1 [Bos taurus]","gi|982994280|ref|XM_015466295.1|",3321,0,"PREDICTED: Bos taurus WNT1 inducible signaling pathway protein 1 (WISP1), mRNA","O95388",535,{"v":6e-179,"d":"6.00E-179"},"WNT1-inducible-signaling pathway protein 1",".",".",".",".","pfam00219","IGFBP","Insulin-like growth factor binding protein.","GO:0007155|cell adhesion;GO:0007267|cell-cell signaling;GO:0060548|negative regulation of cell death;GO:0001558|regulation of cell growth;GO:0007165|signal transduction;GO:0016055|Wnt signaling pathway;","GO:0005829|cytosol;GO:0005615|extracellular space;","GO:0008201|heparin binding;GO:0005520|insulin-like growth factor binding;GO:0005178|integrin binding;",".","."]
["gene17901",358,312,518,354.640040908817,713,840,776,854.881167692671,0.414841330364069,-1.26936845883439,{"v":4.48421899023043e-05,"d":"4.48E-05"},0.00146887774983082,"down","yes","PDE7A","protein_coding","chrNC_037341.1:30105783-30211954:-","gi|528914710|ref|XP_005194568.1|",2463,0,"PREDICTED: high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X2 [Bos taurus]","gi|982994437|ref|XM_005194511.3|",3116,0,"PREDICTED: Bos taurus phosphodiesterase 7A (PDE7A), transcript variant X2, mRNA","P70453",900,0,"High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0006198|cAMP catabolic process;GO:0007165|signal transduction;",".","GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0004112|cyclic-nucleotide phosphodiesterase activity;GO:0046872|metal ion binding;","K18436","PDE7; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 [EC:3.1.4.53]"]
["gene17903",28,14,24,19.2564173469006,83,109,69,95.9315258084685,0.200730856562699,-2.3166656885095,0.000164592123154183,0.00439286984631618,"down","yes","LOC101902754","pseudogene","chrNC_037341.1:30144400-30145897:-","gi|311257294|ref|XP_003127050.1|",696,{"v":1e-85,"d":"1.00E-85"},"PREDICTED: cytochrome b-c1 complex subunit Rieske, mitochondrial [Sus scrofa]","gi|942046993|ref|XR_001351368.1|",954,0,"PREDICTED: Bos mutus cytochrome b-c1 complex subunit Rieske, mitochondrial pseudogene (LOC102277100), misc_RNA","P13272",265,{"v":1e-84,"d":"1.00E-84"},"Cytochrome b-c1 complex subunit Rieske, mitochondrial","YEL024w",162,{"v":2e-46,"d":"2.00E-46"},"COG0723","pfam09165","Ubiq-Cytc-red_N","Ubiquinol-cytochrome c reductase 8 kDa, N-terminal. Members of this family adopt a structure consisting of many antiparallel beta sheets, with few alpha helices, in a non-globular arrangement. They are required for proper functioning of the respiratory chain.",".","GO:0016021|integral component of membrane;GO:0005743|mitochondrial inner membrane;GO:0005739|mitochondrion;GO:0070469|respiratory chain;","GO:0051537|2 iron, 2 sulfur cluster binding;GO:0046872|metal ion binding;GO:0008121|ubiquinol-cytochrome-c reductase activity;","K00411","UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:1.10.2.2]"]
["gene1793",1,5,0,1.89921163286917,59,33,43,49.6847413010492,0.0382252495059094,-4.70933027132105,0.000505714467388103,0.0106405158326327,"down","yes","ACVR1C","protein_coding","chrNC_037329.1:38753355-38831144:+","gi|329112529|ref|NP_001179808.2|",2511,0,"activin receptor type-1C precursor [Bos taurus]","gi|329112528|ref|NM_001192879.2|",1714,0,"Bos taurus activin A receptor, type IC (ACVR1C), mRNA","Q8NER5",959,0,"Activin receptor type-1C",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0030262|apoptotic nuclear changes;GO:0030154|cell differentiation;GO:0019915|lipid storage;GO:1901383|negative regulation of chorionic trophoblast cell proliferation;GO:0046676|negative regulation of insulin secretion;GO:1901164|negative regulation of trophoblast cell migration;GO:0038092|nodal signaling pathway;GO:0043280|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0006468|protein phosphorylation;GO:0002021|response to dietary excess;GO:0009749|response to glucose;GO:0032868|response to insulin;","GO:0048179|activin receptor complex;GO:0005886|plasma membrane;","GO:0016361|activin receptor activity, type I;GO:0005524|ATP binding;GO:0019838|growth factor binding;GO:0046872|metal ion binding;GO:0038100|nodal binding;GO:0004674|protein serine/threonine kinase activity;","K13568","ACVR1C, ALK7; activin receptor type-1C [EC:2.7.11.30]"]
["gene18034",34,126,238,123.24856643119,2162,1348,1712,1920.77143900944,0.0641661802794977,-3.96204308555707,{"v":4.94624807842081e-09,"d":"4.95E-09"},{"v":5.55596078446552e-07,"d":"5.56E-07"},"down","yes","FABP4","protein_coding","chrNC_037341.1:44676559-44680947:-","gi|296480594|tpg|DAA22709.1|",688,{"v":2e-89,"d":"2.00E-89"},"TPA: fatty acid-binding protein, adipocyte [Bos taurus]","gi|31342348|ref|NM_174314.2|",622,0,"Bos taurus fatty acid binding protein 4, adipocyte (FABP4), mRNA","P48035",268,{"v":2e-90,"d":"2.00E-90"},"Fatty acid-binding protein, adipocyte",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0050873|brown fat cell differentiation;GO:0071285|cellular response to lithium ion;GO:0042632|cholesterol homeostasis;GO:0001816|cytokine production;GO:0006631|fatty acid metabolic process;GO:0010629|negative regulation of gene expression;GO:0006469|negative regulation of protein kinase activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:0008284|positive regulation of cell proliferation;GO:0010628|positive regulation of gene expression;GO:0050729|positive regulation of inflammatory response;GO:0050872|white fat cell differentiation;","GO:0005829|cytosol;GO:0005634|nucleus;","GO:0005504|fatty acid binding;","K08753","FABP4, aP2; fatty acid-binding protein 4, adipocyte"]
["gene18038",0,4,18,6.8390601217722,245,248,221,262.361107552845,0.0260673549733154,-5.26161198820065,{"v":3.93687420859634e-08,"d":"3.94E-08"},{"v":3.66806741675172e-06,"d":"3.67E-06"},"down","yes","MAL2","protein_coding","chrNC_037341.1:44987022-45020255:-","gi|126165298|ref|NP_001075188.1|",642,{"v":2e-74,"d":"2.00E-74"},"protein MAL2 [Bos taurus]","gi|126165297|ref|NM_001081719.1|",2818,0,"Bos taurus mal, T-cell differentiation protein 2 (MAL2), mRNA","A2VE13",251,{"v":6e-76,"d":"6.00E-76"},"Protein MAL2",".",".",".",".","pfam01284","MARVEL","Membrane-associating domain. MARVEL domain-containing proteins are often found in lipid-associating proteins - such as Occludin and MAL family proteins. It may be part of the machinery of membrane apposition events, such as transport vesicle biogenesis.","GO:0001766|membrane raft polarization;GO:0042552|myelination;GO:0008104|protein localization;GO:0045056|transcytosis;","GO:0016324|apical plasma membrane;GO:0016021|integral component of membrane;GO:0045121|membrane raft;","GO:0019911|structural constituent of myelin sheath;",".","."]
["gene18042",23,16,18,16.7660067194842,179,19,138,123.691510560441,0.135546947753472,-2.88313546795671,0.00020422248807284,0.00515634673204089,"down","yes","TNFRSF11B","protein_coding","chrNC_037341.1:45276997-45305174:+","gi|556723560|ref|XP_005957599.1|",2012,0,"PREDICTED: LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 11B [Pantholops hodgsonii]","gi|402747116|ref|NM_001098056.2|",2228,0,"Bos taurus tumor necrosis factor receptor superfamily member 11b (TNFRSF11B), mRNA","A5D7R1",779,0,"Tumor necrosis factor receptor superfamily member 11B",".",".",".",".","pfam00020","TNFR_c6","TNFR/NGFR cysteine-rich region.","GO:0097190|apoptotic signaling pathway;GO:0030198|extracellular matrix organization;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0007275|multicellular organismal development;GO:0042489|negative regulation of odontogenesis of dentin-containing tooth;GO:0042981|regulation of apoptotic process;GO:0042127|regulation of cell proliferation;GO:0032496|response to lipopolysaccharide;","GO:0005615|extracellular space;GO:0005887|integral component of plasma membrane;","GO:0005031|tumor necrosis factor-activated receptor activity;","K05148","TNFRSF11B, OPG; tumor necrosis factor receptor superfamily member 11B"]
["gene18111",3,1,7,3.25943882497194,38,16,37,33.4309854036267,0.0974975396512944,-3.35849037683721,0.000805044320766195,0.0153534221362168,"down","yes","RIMS2","protein_coding","chrNC_037341.1:60359141-60968025:-","gi|965839404|ref|XP_014962652.1|",2272,0,"PREDICTED: regulating synaptic membrane exocytosis protein 2 isoform X12 [Ovis aries musimon]","gi|982944938|ref|XM_015474493.1|",3712,0,"PREDICTED: Bos taurus regulating synaptic membrane exocytosis 2 (RIMS2), transcript variant X3, mRNA","Q9EQZ7",637,0,"Regulating synaptic membrane exocytosis protein 2",".",".",".",".","pfam00168","C2","C2 domain.","GO:0017156|calcium ion-dependent exocytosis;GO:0048791|calcium ion-dependent exocytosis of neurotransmitter;GO:0019933|cAMP-mediated signaling;GO:0030073|insulin secretion;GO:0006886|intracellular protein transport;GO:0007269|neurotransmitter secretion;GO:1903861|positive regulation of dendrite extension;GO:2000463|positive regulation of excitatory postsynaptic potential;GO:0010628|positive regulation of gene expression;GO:0097151|positive regulation of inhibitory postsynaptic potential;GO:0017157|regulation of exocytosis;GO:0042391|regulation of membrane potential;GO:2000300|regulation of synaptic vesicle exocytosis;GO:0061669|spontaneous neurotransmitter secretion;GO:0016082|synaptic vesicle priming;","GO:0030054|cell junction;GO:0060077|inhibitory synapse;GO:0005622|intracellular;GO:0043005|neuron projection;GO:0048786|presynaptic active zone;GO:0032991|macromolecular complex;GO:0045202|synapse;","GO:0044325|ion channel binding;GO:0046872|metal ion binding;GO:0019904|protein domain specific binding;GO:0046982|protein heterodimerization activity;GO:0017137|Rab GTPase binding;","K15297","RIMS2, RIM2; regulating synaptic membrane exocytosis protein 2"]
["gene1816",2,0,1,0.828368107280525,30,7,17,19.9184947921777,0.0415878868319828,-4.58769280929807,0.0016461394972108,0.0266852306789325,"down","yes","RPRM","protein_coding","chrNC_037329.1:42650738-42652184:+","gi|123959768|ref|NP_001074208.1|",531,{"v":2e-62,"d":"2.00E-62"},"protein reprimo [Bos taurus]","gi|123959767|ref|NM_001080739.1|",1447,0,"Bos taurus reprimo, TP53 dependent G2 arrest mediator candidate (RPRM), mRNA","Q1RMT2",209,{"v":6e-64,"d":"6.00E-64"},"Protein reprimo",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.","GO:0007050|cell cycle arrest;GO:0007346|regulation of mitotic cell cycle;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;",".","K10128","RPRM; reprimo, TP53-dependent G2 arrest mediator candidate"]
["gene18301",2,0,0,0.521246473672423,50,1,29,29.5236058433777,0.0176552442962972,-5.82375940591209,0.00302208099347386,0.0415818816304114,"down","yes","LOC100335514","misc_RNA","chrNC_037341.1:80861788-80864949:-","gi|296480453|tpg|DAA22568.1|",353,{"v":6e-39,"d":"6.00E-39"},"TPA: hypothetical protein BOS_14149 [Bos taurus]","gi|594103529|ref|XM_006074708.1|",371,0,"PREDICTED: Bubalus bubalis zinc finger, AN1-type domain 1 (ZFAND1), mRNA",".",".",".",".",".",".",".",".","pfam04698","Rab_eff_C","Rab effector MyRIP/melanophilin C-terminus. This domain is found at the C-terminus of the Rab effector proteins MyRIP and melanophilin.",".",".",".",".","."]
["gene1848",27,50,27,31.714995462326,254,69,195,190.648950415614,0.166352845862447,-2.58768154771364,{"v":6.53450473462296e-05,"d":"6.53E-05"},0.00203755141621342,"down","yes","KIF5C","protein_coding","chrNC_037329.1:47209453-47368948:-","gi|528939217|ref|XP_005202522.1|",4478,0,"PREDICTED: kinesin heavy chain isoform 5C isoform X1 [Bos taurus]","gi|982913552|ref|XM_005202465.3|",7035,0,"PREDICTED: Bos taurus kinesin family member 5C (KIF5C), transcript variant X1, mRNA","O60282",1713,0,"Kinesin heavy chain isoform 5C","SPAC1834.07",317,{"v":2e-92,"d":"2.00E-92"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0007411|axon guidance;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0007018|microtubule-based movement;GO:0008045|motor neuron axon guidance;GO:0051028|mRNA transport;GO:0006996|organelle organization;GO:0008104|protein localization;","GO:0044295|axonal growth cone;GO:0035253|ciliary rootlet;GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0043025|neuronal cell body;","GO:0005524|ATP binding;GO:0008574|ATP-dependent microtubule motor activity, plus-end-directed;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;","K10396","KIF5; kinesin family member 5"]
["gene18488",300,287,363,283.727097982896,628,476,459,575.098999275121,0.493353489295786,-1.01930638234046,0.001588269494324,0.0260280970376554,"down","yes","FDX1","protein_coding","chrNC_037342.1:20459530-20494938:+","gi|162615|gb|AAA30357.1|",685,{"v":3e-84,"d":"3.00E-84"},"adrenodoxin precursor, partial [Bos taurus]","gi|942038566|ref|XM_005889823.2|",1182,0,"PREDICTED: Bos mutus ferredoxin 1 (FDX1), mRNA","P00257",268,{"v":1e-85,"d":"1.00E-85"},"Adrenodoxin, mitochondrial","RC0261",115,{"v":5e-30,"d":"5.00E-30"},"COG0633",".",".",".","GO:0071320|cellular response to cAMP;GO:1904322|cellular response to forskolin;GO:0008203|cholesterol metabolic process;GO:0042446|hormone biosynthetic process;GO:0055114|oxidation-reduction process;GO:0006694|steroid biosynthetic process;","GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0051537|2 iron, 2 sulfur cluster binding;GO:0009055|electron carrier activity;GO:0046872|metal ion binding;GO:0008022|protein C-terminus binding;GO:0042803|protein homodimerization activity;",".","."]
["gene18511",20806,38990,73663,40823.7402743528,197688,133834,195260,193488.446719983,0.210987999368422,-2.2447671516138,0.00139441535218417,0.0235408665166667,"down","yes","CRYAB","protein_coding","chrNC_037342.1:22242397-22245623:-","gi|2852648|gb|AAC19161.1|",953,{"v":8e-129,"d":"8.00E-129"},"unknown [Homo sapiens]","gi|74267797|gb|BC102745.1|",610,0,"Bos taurus crystallin, alpha B, mRNA (cDNA clone MGC:128019 IMAGE:7962636), complete cds","P02510",353,{"v":3e-123,"d":"3.00E-123"},"Alpha-crystallin B chain",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.","GO:0060561|apoptotic process involved in morphogenesis;GO:0071480|cellular response to gamma radiation;GO:0002088|lens development in camera-type eye;GO:0007517|muscle organ development;GO:0043066|negative regulation of apoptotic process;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010629|negative regulation of gene expression;GO:0032387|negative regulation of intracellular transport;GO:0032463|negative regulation of protein homooligomerization;GO:0051260|protein homooligomerization;GO:0050821|protein stabilization;GO:0042542|response to hydrogen peroxide;GO:0001666|response to hypoxia;GO:0007021|tubulin complex assembly;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0043209|myelin sheath;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0030018|Z disc;","GO:0001540|beta-amyloid binding;GO:0046872|metal ion binding;GO:0042803|protein homodimerization activity;GO:0044877|macromolecular complex binding;GO:0005212|structural constituent of eye lens;GO:0051082|unfolded protein binding;","K09542","CRYAB; crystallin, alpha B"]
["gene18513",54,30,194,83.4867820853249,2430,448,2013,1799.30531451292,0.0463994528399006,-4.42974839713343,0.00064255760107554,0.0129286395742498,"down","yes","C15H11orf52","protein_coding","chrNC_037342.1:22251288-22258362:+","gi|742214611|ref|XP_010861175.1|",484,{"v":1e-55,"d":"1.00E-55"},"PREDICTED: uncharacterized protein C11orf52 homolog isoform X1 [Bison bison bison]","gi|741890117|ref|XM_010822751.1|",1255,0,"PREDICTED: Bos taurus chromosome 15 open reading frame, human C11orf52 (C15H11orf52), transcript variant X2, mRNA","Q96A22",99,{"v":2e-23,"d":"2.00E-23"},"Uncharacterized protein C11orf52",".",".",".",".","pfam15147","DUF4578","Domain of unknown function (DUF4578). This family of proteins is found in eukaryotes. Proteins in this family are typically between 44 and 137 amino acids in length.",".","GO:0070062|extracellular exosome;",".",".","."]
["gene18662",330,212,223,223.969940442354,468,411,421,477.724943100002,0.468826138716961,-1.09287508752891,0.00129697215376734,0.0222379281965961,"down","yes","TBCEL","protein_coding","chrNC_037342.1:31648679-31715116:+","gi|329664356|ref|NP_001192382.1|",2177,0,"tubulin-specific chaperone cofactor E-like protein [Bos taurus]","gi|982945944|ref|XM_005216052.3|",7068,0,"PREDICTED: Bos taurus tubulin folding cofactor E-like (TBCEL), transcript variant X1, mRNA","Q5QJ74",838,0,"Tubulin-specific chaperone cofactor E-like protein",".",".",".",".","pfam14580","LRR_9","Leucine-rich repeat.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;",".",".","."]
["gene18689",230,92,178,144.761021741577,543,627,577,641.338635364294,0.225716982821952,-2.1474131246905,{"v":4.23862527203354e-09,"d":"4.24E-09"},{"v":4.83728870545555e-07,"d":"4.84E-07"},"down","yes","SCN3B","protein_coding","chrNC_037342.1:34231050-34253814:-","gi|114053341|ref|NP_001039960.1|",1080,{"v":2e-144,"d":"2.00E-144"},"sodium channel subunit beta-3 precursor [Bos taurus]","gi|114053340|ref|NM_001046495.1|",1198,0,"Bos taurus sodium channel, voltage gated, type III beta subunit (SCN3B), mRNA","Q2KI11",420,{"v":6e-146,"d":"6.00E-146"},"Sodium channel subunit beta-3",".",".",".",".","pfam07686","V-set","Immunoglobulin V-set domain. This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.","GO:0086014|atrial cardiac muscle cell action potential;GO:0010460|positive regulation of heart rate;GO:0010765|positive regulation of sodium ion transport;GO:0072659|protein localization to plasma membrane;GO:0060371|regulation of atrial cardiac muscle cell membrane depolarization;GO:0086091|regulation of heart rate by cardiac conduction;GO:2000649|regulation of sodium ion transmembrane transporter activity;GO:0060373|regulation of ventricular cardiac muscle cell membrane depolarization;GO:0086015|SA node cell action potential;GO:0086005|ventricular cardiac muscle cell action potential;","GO:0001518|voltage-gated sodium channel complex;GO:0030018|Z disc;","GO:0044325|ion channel binding;GO:0017080|sodium channel regulator activity;GO:0005244|voltage-gated ion channel activity;GO:0086006|voltage-gated sodium channel activity involved in cardiac muscle cell action potential;","K04847","SCN3B; voltage-gated sodium channel type III beta"]
["gene18723",188,328,459,297.457397131089,748,576,601,707.908077156611,0.42019212201372,-1.25087898103985,0.00025906773889239,0.00619050390145626,"down","yes","CYP2R1","protein_coding","chrNC_037342.1:37890068-37915285:+","gi|742231047|ref|XP_010828872.1|",2358,0,"PREDICTED: vitamin D 25-hydroxylase isoform X4 [Bison bison bison]","gi|742231046|ref|XM_010830570.1|",3217,0,"PREDICTED: Bison bison bison vitamin D 25-hydroxylase (LOC104981447), transcript variant X4, mRNA","Q6VVX0",850,0,"Vitamin D 25-hydroxylase",".",".",".",".","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0010164|response to cesium ion;GO:0010212|response to ionizing radiation;GO:0042359|vitamin D metabolic process;GO:0006766|vitamin metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0031090|organelle membrane;","GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0008395|steroid hydroxylase activity;GO:0030343|vitamin D3 25-hydroxylase activity;","K07419","CYP2R1; vitamin D 25-hydroxylase [EC:1.14.13.159]"]
["gene18724",121,89,123,98.4782460403648,413,319,376,407.161061812409,0.241865579193662,-2.04772262635497,{"v":1.94971173439796e-07,"d":"1.95E-07"},{"v":1.48339267984288e-05,"d":"1.48E-05"},"down","yes","PDE3B","protein_coding","chrNC_037342.1:37933483-38095487:-","gi|194673277|ref|XP_618666.4|",4910,0,"PREDICTED: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [Bos taurus]","gi|982995113|ref|XM_618666.8|",5543,0,"PREDICTED: Bos taurus phosphodiesterase 3B (PDE3B), mRNA","Q13370",1514,0,"cGMP-inhibited 3',5'-cyclic phosphodiesterase B",".",".",".",".","pfam00233","PDEase_I","3'5'-cyclic nucleotide phosphodiesterase.","GO:0001525|angiogenesis;GO:0006198|cAMP catabolic process;GO:0032869|cellular response to insulin stimulus;GO:0007186|G-protein coupled receptor signaling pathway;GO:0016525|negative regulation of angiogenesis;GO:0043951|negative regulation of cAMP-mediated signaling;GO:0007162|negative regulation of cell adhesion;GO:0033629|negative regulation of cell adhesion mediated by integrin;GO:0050995|negative regulation of lipid catabolic process;","GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0032045|guanyl-nucleotide exchange factor complex;GO:0016021|integral component of membrane;GO:0016020|membrane;","GO:0004115|3',5'-cyclic-AMP phosphodiesterase activity;GO:0047555|3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114|3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004119|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity;GO:0046872|metal ion binding;GO:0043422|protein kinase B binding;","K13296","PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [EC:3.1.4.17]"]
["gene18729",892,880,782,761.036602441237,2245,1205,1858,1952.01700984347,0.389871911260785,-1.3589278769164,0.000507419204535828,0.0106528162800675,"down","yes","RRAS2","protein_coding","chrNC_037342.1:38360008-38445017:+","gi|593715096|ref|XP_007104022.1|",903,{"v":7e-115,"d":"7.00E-115"},"PREDICTED: ras-related protein R-Ras2-like isoform X2 [Physeter catodon]","gi|982945769|ref|XM_010812454.2|",1959,0,"PREDICTED: Bos taurus related RAS viral (r-ras) oncogene homolog 2 (RRAS2), transcript variant X2, mRNA","P62071",351,{"v":1e-115,"d":"1.00E-115"},"Ras-related protein R-Ras2","SPAC17H9.09c",197,{"v":2e-57,"d":"2.00E-57"},"COG1100","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0009987|cellular process;GO:0030335|positive regulation of cell migration;GO:0007265|Ras protein signal transduction;GO:1901214|regulation of neuron death;","GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07830","RRAS2, TC21; Ras-related protein R-Ras2"]
["gene18769",376,423,1352,651.847363992957,6103,3202,5153,5316.2941445021,0.122613110989554,-3.02781484058722,{"v":2.50847999439745e-05,"d":"2.51E-05"},0.000906323265262789,"down","yes","AMPD3","protein_coding","chrNC_037342.1:42181646-42225130:-","gi|555972017|ref|XP_005898017.1|",3734,0,"PREDICTED: AMP deaminase 3 [Bos mutus]","gi|982995170|ref|XM_015466514.1|",4349,0,"PREDICTED: Bos taurus adenosine monophosphate deaminase 3 (AMPD3), transcript variant X2, mRNA","Q01432",1401,0,"AMP deaminase 3","YML035c",576,0,"COG1816","pfam00962","A_deaminase","Adenosine/AMP deaminase.","GO:0046031|ADP metabolic process;GO:0006196|AMP catabolic process;GO:0046034|ATP metabolic process;GO:0097009|energy homeostasis;GO:0034101|erythrocyte homeostasis;GO:0046039|GTP metabolic process;GO:0032264|IMP salvage;GO:0043312|neutrophil degranulation;GO:0043101|purine-containing compound salvage;","GO:0005829|cytosol;GO:0005576|extracellular region;GO:0034774|secretory granule lumen;","GO:0003876|AMP deaminase activity;GO:0046872|metal ion binding;","K01490","AMPD; AMP deaminase [EC:3.5.4.6]"]
["gene1908",307,191,322,241.498576458985,816,347,603,650.006099767507,0.371532784915962,-1.42843857174463,0.00242486532831744,0.0353096323186114,"down","yes","MCM6","protein_coding","chrNC_037329.1:61489675-61524287:+","gi|594049676|ref|XP_006049206.1|",4331,0,"PREDICTED: DNA replication licensing factor MCM6 [Bubalus bubalis]","gi|942065519|ref|XM_005899493.2|",2722,0,"PREDICTED: Bos mutus minichromosome maintenance complex component 6 (MCM6), mRNA","Q2KIZ8",1669,0,"DNA replication licensing factor MCM6","SPBC211.04c",668,0,"COG1241","pfam00493","MCM","MCM2/3/5 family.","GO:0007049|cell cycle;GO:0006270|DNA replication initiation;","GO:0042555|MCM complex;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0003677|DNA binding;GO:0003678|DNA helicase activity;","K02542","MCM6; DNA replication licensing factor MCM6 [EC:3.6.4.12]"]
["gene19151",61,11,44,33.0162637970379,117,110,105,122.001652428061,0.270621447660359,-1.8856519126052,0.000663732702392421,0.0132611748823236,"down","yes","LOC784976","protein_coding","chrNC_037342.1:50310251-50311338:+","gi|440889887|gb|ELR44718.1|",1646,0,"hypothetical protein M91_10416, partial [Bos mutus]","gi|982995482|ref|XM_015466566.1|",1088,0,"PREDICTED: Bos taurus olfactory receptor 51F2 (LOC784976), mRNA","Q8NH61",406,{"v":6e-139,"d":"6.00E-139"},"Olfactory receptor 51F2",".",".",".",".","pfam13853","7tm_4","Olfactory receptor. The members of this family are transmembrane olfactory receptors.","GO:0007165|signal transduction;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["gene19153",84,19,70,49.6175021517341,185,120,201,185.741155542038,0.267132515714883,-1.90437250152194,0.000100226815391279,0.00290017370175312,"down","yes","LOC785036","protein_coding","chrNC_037342.1:50341420-50345305:+","gi|741890621|ref|XP_001253182.2|",1643,0,"PREDICTED: olfactory receptor 51I2 [Bos taurus]","gi|982995472|ref|XM_001253181.4|",2020,0,"PREDICTED: Bos taurus olfactory receptor 51I2 (LOC785036), mRNA","Q9H344",319,{"v":4e-97,"d":"4.00E-97"},"Olfactory receptor 51I2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007608|sensory perception of smell;GO:0007165|signal transduction;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;GO:0004984|olfactory receptor activity;","K04257","OLFR; olfactory receptor"]
["gene1920",0,0,0,0,7,26,25,21.1823756363508,{"$error":"#NAME?"},{"$error":"#NAME?"},{"v":3.36443392993414e-05,"d":"3.36E-05"},0.00116610978989336,"down","yes","ACMSD","protein_coding","chrNC_037329.1:62363200-62424582:-","gi|115496732|ref|NP_001069162.1|",1607,0,"2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [Bos taurus]","gi|982913860|ref|XM_015475769.1|",1644,0,"PREDICTED: Bos taurus aminocarboxymuconate semialdehyde decarboxylase (ACMSD), transcript variant X3, mRNA","Q0II68",623,0,"2-amino-3-carboxymuconate-6-semialdehyde decarboxylase","slr0619",128,{"v":6e-32,"d":"6.00E-32"},"COG2159","pfam04909","Amidohydro_2","Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.","GO:0051259|protein oligomerization;","GO:0005829|cytosol;","GO:0001760|aminocarboxymuconate-semialdehyde decarboxylase activity;GO:0016831|carboxy-lyase activity;GO:0016787|hydrolase activity;GO:0008270|zinc ion binding;","K03392","ACMSD; aminocarboxymuconate-semialdehyde decarboxylase [EC:4.1.1.45]"]
["gene19277",599,1132,1246,909.763287202447,4074,2196,3499,3591.68003761193,0.253297420058424,-1.98109571222254,{"v":1.5298141522494e-05,"d":"1.53E-05"},0.000610449336752832,"down","yes","NEU3","protein_coding","chrNC_037342.1:54253336-54270762:+","gi|982946426|ref|XP_015330269.1|",2549,0,"PREDICTED: sialidase-3 isoform X1 [Bos taurus]","gi|742156243|ref|XM_010847578.1|",5881,0,"PREDICTED: Bison bison bison sialidase 3 (membrane sialidase) (NEU3), transcript variant X2, mRNA","O97859",882,0,"Sialidase-3",".",".",".",".","pfam13088","BNR_2","BNR repeat-like domain. This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.","GO:0006689|ganglioside catabolic process;GO:0009313|oligosaccharide catabolic process;","GO:0005737|cytoplasm;GO:0043231|intracellular membrane-bounded organelle;GO:0005886|plasma membrane;","GO:0052794|exo-alpha-(2->3)-sialidase activity;GO:0052795|exo-alpha-(2->6)-sialidase activity;GO:0052796|exo-alpha-(2->8)-sialidase activity;","K12357","NEU2_3_4; sialidase-2/3/4 [EC:3.2.1.18]"]
["gene19340",0,0,0,0,0,35,10,16.454293799163,{"$error":"#NAME?"},{"$error":"#NAME?"},0.000578213067945952,0.0118427832315621,"down","yes","SLC5A12","protein_coding","chrNC_037342.1:57364696-57415989:-","gi|155371849|ref|NP_001094529.1|",3188,0,"sodium-coupled monocarboxylate transporter 2 [Bos taurus]","gi|402744589|ref|NM_001101059.2|",2927,0,"Bos taurus solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 (SLC5A12), mRNA","A7MBD8",1232,0,"Sodium-coupled monocarboxylate transporter 2","sll1087",160,{"v":1e-40,"d":"1.00E-40"},"COG0591","pfam00474","SSF","Sodium:solute symporter family. Membership of this family is supported by a significant blast score.","GO:0006814|sodium ion transport;","GO:0016324|apical plasma membrane;GO:0016021|integral component of membrane;","GO:0015129|lactate transmembrane transporter activity;GO:0015293|symporter activity;","K14388","SLC5A8_12, SMCT; solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12"]
["gene19416",30,18,22,20.4742912701832,100,142,142,140.74719397535,0.145468557431908,-2.78122074202277,{"v":1.18930048187931e-06,"d":"1.19E-06"},{"v":7.11361258878379e-05,"d":"7.11E-05"},"down","yes","PRR5L","protein_coding","chrNC_037342.1:66763192-66918835:+","gi|528978324|ref|XP_005216423.1|",1928,0,"PREDICTED: proline-rich protein 5-like isoform X1 [Bos taurus]","gi|982946704|ref|XM_005216368.3|",2436,0,"PREDICTED: Bos taurus proline rich 5 like (PRR5L), transcript variant X4, mRNA","Q5E9R0",662,0,"Proline-rich protein 5-like",".",".",".",".","pfam08539","HbrB","HbrB-like. HbrB is involved hyphal growth and polarity.","GO:0034599|cellular response to oxidative stress;GO:0001933|negative regulation of protein phosphorylation;GO:0009968|negative regulation of signal transduction;GO:0090316|positive regulation of intracellular protein transport;GO:0061014|positive regulation of mRNA catabolic process;GO:0010762|regulation of fibroblast migration;GO:0038203|TORC2 signaling;","GO:0031932|TORC2 complex;",".",".","."]
["gene1953",18,61,323,123.882284350071,434,274,376,398.495751101766,0.310874793539353,-1.68559445057899,0.000875120051969339,0.016262740860533,"down","yes","EN1","protein_coding","chrNC_037329.1:70606399-70615085:-","gi|555980322|ref|XP_005902088.1|",722,{"v":6e-84,"d":"6.00E-84"},"PREDICTED: homeobox protein engrailed-1 [Bos mutus]","gi|982977495|ref|XM_003581845.4|",2534,0,"PREDICTED: Bos taurus engrailed homeobox 1 (EN1), mRNA","Q05925",277,{"v":3e-80,"d":"3.00E-80"},"Homeobox protein engrailed-1",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0008344|adult locomotory behavior;GO:0009653|anatomical structure morphogenesis;GO:0021549|cerebellum development;GO:0071542|dopaminergic neuron differentiation;GO:0009953|dorsal/ventral pattern formation;GO:0042756|drinking behavior;GO:1990403|embryonic brain development;GO:0035115|embryonic forelimb morphogenesis;GO:0030901|midbrain development;GO:0030917|midbrain-hindbrain boundary development;GO:0035264|multicellular organism growth;GO:0043524|negative regulation of neuron apoptotic process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0048666|neuron development;GO:0043473|pigmentation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0009954|proximal/distal pattern formation;GO:0001501|skeletal system development;GO:0035176|social behavior;","GO:0005634|nucleus;","GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09319","EN; homeobox protein engrailed"]
["gene196",199,43,199,127.073089424302,330,295,288,335.564994487431,0.378683985254193,-1.40093368471044,0.000861968821459493,0.0161476247177024,"down","yes","LOC112447290","pseudogene","chrNC_037328.1:29218717-29230130:-","gi|545503787|ref|XP_537074.4|",269,{"v":2e-59,"d":"2.00E-59"},"PREDICTED: 60S ribosomal protein L5 [Canis lupus familiaris]","gi|850474981|gb|CP011886.1|",2166,0,"Ovis canadensis canadensis isolate 43U chromosome 1 sequence","Q58DW5",92.4,{"v":9e-57,"d":"9.00E-57"},"60S ribosomal protein L5","SPBC11C11.09c",69.3,{"v":3e-11,"d":"3.00E-11"},"COG0256","pfam14204","Ribosomal_L18_c","Ribosomal L18 C-terminal region. This domain is the C-terminal end of ribosomal L18/L5 proteins.","GO:0000027|ribosomal large subunit assembly;GO:0006412|translation;","GO:0005737|cytoplasm;GO:0022625|cytosolic large ribosomal subunit;GO:0005730|nucleolus;","GO:0008097|5S rRNA binding;GO:0003735|structural constituent of ribosome;","K02932","RP-L5e, RPL5; large subunit ribosomal protein L5e"]
["gene1968",122,44,73,68.6354920324993,333,155,269,278.449554218852,0.246491657079666,-2.02038927787234,0.000172774696209372,0.00453073056760072,"down","yes","LOC100139473","pseudogene","chrNC_037329.1:71689974-71694888:+","gi|147906546|ref|NP_001091464.1|",837,0,"tumor susceptibility gene 101 protein [Bos taurus]","gi|850477813|gb|CP011887.1|",2773,0,"Ovis canadensis canadensis isolate 43U chromosome 2 sequence","Q99816",315,{"v":9e-175,"d":"9.00E-175"},"Tumor susceptibility gene 101 protein",".",".",".",".","pfam05743","UEV","UEV domain. This family includes the eukaryotic tumor susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. TSG101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumor suppressor for sporadic forms of breast cancer. This family is related to the ubiquitin conjugating enzymes.","GO:0097352|autophagosome maturation;GO:0007050|cell cycle arrest;GO:0051301|cell division;GO:0016197|endosomal transport;GO:0008333|endosome to lysosome transport;GO:1990182|exosomal secretion;GO:0006858|extracellular transport;GO:0030216|keratinocyte differentiation;GO:0016236|macroautophagy;GO:0036258|multivesicular body assembly;GO:0008285|negative regulation of cell proliferation;GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0007175|negative regulation of epidermal growth factor-activated receptor activity;GO:0045892|negative regulation of transcription, DNA-templated;GO:1903543|positive regulation of exosomal secretion;GO:2000397|positive regulation of ubiquitin-dependent endocytosis;GO:1903774|positive regulation of viral budding via host ESCRT complex;GO:0048524|positive regulation of viral process;GO:1902188|positive regulation of viral release from host cell;GO:0006513|protein monoubiquitination;GO:0015031|protein transport;GO:0001558|regulation of cell growth;GO:1903551|regulation of extracellular exosome assembly;GO:0043405|regulation of MAP kinase activity;GO:1903772|regulation of viral budding via host ESCRT complex;GO:0043162|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0046755|viral budding;GO:0039702|viral budding via host ESCRT complex;GO:0019058|viral life cycle;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005769|early endosome;GO:0031901|early endosome membrane;GO:0005768|endosome;GO:0010008|endosome membrane;GO:0000813|ESCRT I complex;GO:0070062|extracellular exosome;GO:0090543|Flemming body;GO:0005770|late endosome;GO:0031902|late endosome membrane;GO:0005815|microtubule organizing center;GO:0005771|multivesicular body;GO:0005730|nucleolus;GO:0005886|plasma membrane;","GO:0048306|calcium-dependent protein binding;GO:0003677|DNA binding;GO:0030374|ligand-dependent nuclear receptor transcription coactivator activity;GO:0042803|protein homodimerization activity;GO:0044877|macromolecular complex binding;GO:0003714|transcription corepressor activity;GO:0043130|ubiquitin binding;GO:0031625|ubiquitin protein ligase binding;GO:0046790|virion binding;","K12183","TSG101, STP22, VPS23; ESCRT-I complex subunit TSG101"]
["gene19772",442,121,136,196.617852036305,527,520,567,592.480947154933,0.331855147377236,-1.59137444296182,{"v":7.29923768765652e-05,"d":"7.30E-05"},0.00223623357063587,"down","yes","MPEG1","protein_coding","chrNC_037342.1:82340376-82344478:-","gi|114050823|ref|NP_001039929.1|",3323,0,"macrophage-expressed gene 1 protein precursor [Bos taurus]","gi|114050822|ref|NM_001046464.1|",4095,0,"Bos taurus macrophage expressed 1 (MPEG1), mRNA","Q2KJC3",1274,0,"Macrophage-expressed gene 1 protein",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene1984",532,405,575,447.972161400193,1167,779,977,1074.74118950735,0.416818640407313,-1.26250829754479,0.000150535142319327,0.00409429756483576,"down","yes","NIFK","protein_coding","chrNC_037329.1:73387424-73397871:-","gi|77735665|ref|NP_001029526.1|",1403,0,"MKI67 FHA domain-interacting nucleolar phosphoprotein [Bos taurus]","gi|402691667|ref|NM_001034354.2|",1597,0,"Bos taurus nucleolar protein interacting with the FHA domain of MKI67 (NIFK), mRNA","Q3SZM1",545,0,"MKI67 FHA domain-interacting nucleolar phosphoprotein",".",".",".",".","pfam00076","RRM_1","RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain). The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.",".","GO:0000794|condensed nuclear chromosome;GO:0005737|cytoplasm;GO:0005730|nucleolus;GO:0005654|nucleoplasm;","GO:0003723|RNA binding;","K14838","NOP15; nucleolar protein 15"]
["gene19908",12,4,33,14.5733634679283,91,131,109,121.434312585845,0.120010260342405,-3.0587703397843,{"v":7.21125756128617e-05,"d":"7.21E-05"},0.00221230526323716,"down","yes","ADORA1","protein_coding","chrNC_037343.1:915523-956858:+","gi|555959662|ref|XP_005891940.1|",1386,0,"PREDICTED: adenosine receptor A1 [Bos mutus]","gi|982947401|ref|XM_010813013.2|",2904,0,"PREDICTED: Bos taurus adenosine A1 receptor (ADORA1), transcript variant X3, mRNA","P28190",538,0,"Adenosine receptor A1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0060079|excitatory postsynaptic potential;GO:0050728|negative regulation of inflammatory response;GO:0002686|negative regulation of leukocyte migration;GO:1900453|negative regulation of long term synaptic depression;GO:0070256|negative regulation of mucus secretion;GO:0003093|regulation of glomerular filtration;GO:0051930|regulation of sensory perception of pain;","GO:0043197|dendritic spine;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0001609|G-protein coupled adenosine receptor activity;","K04265","ADORA1; adenosine A1 receptor"]
["gene19909",136,21,1845,608.966245480011,7597,3538,6379,6440.56425566245,0.094551691638604,-3.40275291989378,0.00161498151576332,0.0263297357864248,"down","yes","MYBPH","protein_coding","chrNC_037343.1:957161-966133:-","gi|115495599|ref|NP_001068903.1|",2184,0,"myosin-binding protein H [Bos taurus]","gi|982947409|ref|XM_010813017.2|",3004,0,"PREDICTED: Bos taurus myosin binding protein H (MYBPH), transcript variant X1, mRNA","Q13203",720,0,"Myosin-binding protein H",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007015|actin filament organization;GO:0007155|cell adhesion;GO:0006942|regulation of striated muscle contraction;GO:0045214|sarcomere organization;GO:0071688|striated muscle myosin thick filament assembly;","GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0032982|myosin filament;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0051371|muscle alpha-actinin binding;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;",".","."]
["gene20002",158,120,90,108.145539949642,461,243,356,389.991417129021,0.277302358974387,-1.8504682056424,{"v":9.60551112643359e-05,"d":"9.61E-05"},0.00281081885075156,"down","yes","LOC515150","protein_coding","chrNC_037343.1:5142272-5150340:+","gi|76677514|ref|XP_593120.2|",954,{"v":2e-123,"d":"2.00E-123"},"PREDICTED: apolipoprotein R [Bos taurus]","gi|982996099|ref|XM_593120.8|",1699,0,"PREDICTED: Bos taurus apolipoprotein R (LOC515150), mRNA","P04003",186,{"v":1e-49,"d":"1.00E-49"},"C4b-binding protein alpha chain",".",".",".",".","pfam00084","Sushi","Sushi domain (SCR repeat).","GO:0006958|complement activation, classical pathway;GO:0045087|innate immune response;GO:0045959|negative regulation of complement activation, classical pathway;GO:0045732|positive regulation of protein catabolic process;GO:0030449|regulation of complement activation;GO:1903027|regulation of opsonization;","GO:0072562|blood microparticle;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0044216|other organism cell;GO:0005886|plasma membrane;","GO:0003723|RNA binding;","K04002","C4BPA; complement component 4 binding protein, alpha"]
["gene20005",404,200,196,231.031163710336,596,407,499,552.255193667062,0.41834131459453,-1.25724761204444,0.000221052444640015,0.00544162838483544,"down","yes","CR2","protein_coding","chrNC_037343.1:5397365-5446688:+","gi|296479427|tpg|DAA21542.1|",7901,0,"TPA: complement component (3d/Epstein Barr virus) receptor 2 [Bos taurus]","gi|312222771|ref|NM_001198991.1|",5243,0,"Bos taurus complement component 3d receptor 2 (CR2), mRNA","P20023",1432,0,"Complement receptor type 2",".",".",".",".","pfam00084","Sushi","Sushi domain (SCR repeat).","GO:0030183|B cell differentiation;GO:0042100|B cell proliferation;GO:0006958|complement activation, classical pathway;GO:0006955|immune response;GO:0045087|innate immune response;GO:0030449|regulation of complement activation;","GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0043235|receptor complex;","GO:0001848|complement binding;GO:0004875|complement receptor activity;GO:0003677|DNA binding;GO:0042803|protein homodimerization activity;GO:0004888|transmembrane signaling receptor activity;GO:0001618|virus receptor activity;","K04012","CR2, CD21; complement receptor type 2"]
["gene20044",1027,591,751,691.989559481569,1990,907,1562,1640.49587630531,0.421817311141344,-1.24530979116095,0.00360107710364595,0.0472752317565198,"down","yes","TROVE2","protein_coding","chrNC_037343.1:12164240-12190163:-","gi|440904744|gb|ELR55214.1|",2824,0,"60 kDa SS-A/Ro ribonucleoprotein, partial [Bos mutus]","gi|329664057|ref|NM_001206183.1|",2860,0,"Bos taurus TROVE domain family member 2 (TROVE2), mRNA","P10155",1046,0,"60 kDa SS-A/Ro ribonucleoprotein",".",".",".",".","pfam05731","TROVE","TROVE domain. This presumed domain is found in TEP1 and Ro60 proteins, that are RNA-binding components of Telomerase, Ro and Vault RNPs. This domain has been named TROVE, (after Telomerase, Ro and Vault). This domain is probably RNA-binding.","GO:0060271|cilium morphogenesis;GO:0002520|immune system development;GO:0009411|response to UV;GO:0007224|smoothened signaling pathway;GO:0006383|transcription from RNA polymerase III promoter;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0046872|metal ion binding;GO:0003723|RNA binding;GO:0030620|U2 snRNA binding;","K11089","TROVE2, SSA2; 60 kDa SS-A/Ro ribonucleoprotein"]
["gene20069",2,5,6,4.00256467135399,80,10,64,56.6735877656926,0.070624868287886,-3.82367991791657,0.000144564012468133,0.0039621093561271,"down","yes","USH2A","protein_coding","chrNC_037343.1:18892333-19815906:-","gi|300794294|ref|NP_001178354.1|",27538,0,"usherin [Bos taurus]","gi|300794293|ref|NM_001191425.1|",16435,0,"Bos taurus Usher syndrome 2A (autosomal recessive, mild) (USH2A), mRNA","O75445",8922,0,"Usherin","Cj1279c",62.8,{"v":2e-08,"d":"2.00E-08"},"COG3401","pfam02210","Laminin_G_2","Laminin G domain. This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.","GO:0045184|establishment of protein localization;GO:0035315|hair cell differentiation;GO:0060113|inner ear receptor cell differentiation;GO:0048496|maintenance of organ identity;GO:0045494|photoreceptor cell maintenance;GO:0050896|response to stimulus;GO:0050953|sensory perception of light stimulus;GO:0007605|sensory perception of sound;GO:0007601|visual perception;","GO:0016324|apical plasma membrane;GO:0005604|basement membrane;GO:0036064|ciliary basal body;GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:1990075|periciliary membrane compartment;GO:0032391|photoreceptor connecting cilium;GO:0001917|photoreceptor inner segment;GO:0002142|stereocilia ankle link complex;GO:0032421|stereocilium bundle;GO:0060171|stereocilium membrane;GO:1990696|USH2 complex;","GO:0005518|collagen binding;GO:0017022|myosin binding;GO:0042803|protein homodimerization activity;",".","."]
["gene20141",1826,2275,4950,2741.70783701802,40428,7625,26709,27550.2014412366,0.0995167981935074,-3.32891612014881,{"v":2.51402506330331e-05,"d":"2.51E-05"},0.000906797080671387,"down","yes","ENAH","protein_coding","chrNC_037343.1:28530499-28690312:-","gi|742174904|ref|XP_010851160.1|",1022,{"v":5e-119,"d":"5.00E-119"},"PREDICTED: protein enabled homolog isoform X4 [Bison bison bison]","gi|982996293|ref|XM_015466762.1|",6095,0,"PREDICTED: Bos taurus enabled homolog (Drosophila) (ENAH), transcript variant X1, mRNA","Q8N8S7",379,{"v":1e-112,"d":"1.00E-112"},"Protein enabled homolog",".",".",".",".","pfam00568","WH1","WH1 domain. WASp Homology domain 1 (WH1) domain. WASP is the protein that is defective in Wiskott-Aldrich syndrome (WAS). The majority of point mutations occur within the amino- terminal WH1 domain. The metabotropic glutamate receptors mGluR1alpha and mGluR5 bind a protein called homer, which is a WH1 domain homologue. A subset of WH1 domains has been termed a \"EVH1\" domain and appear to bind a polyproline motif.","GO:0007411|axon guidance;","GO:0030054|cell junction;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0030175|filopodium;GO:0005925|focal adhesion;GO:0030027|lamellipodium;GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0003779|actin binding;GO:0017124|SH3 domain binding;GO:0050699|WW domain binding;","K05746","ENAH, MENA; enabled"]
["gene20143",255,308,356,276.731272153348,455,551,567,576.946259300294,0.479648264794992,-1.05995125707574,0.000922974333906103,0.0169656918841562,"down","yes","EPHX1","protein_coding","chrNC_037343.1:28833399-28870961:+","gi|77736205|ref|NP_001029801.1|",2400,0,"epoxide hydrolase 1 precursor [Bos taurus]","gi|982947696|ref|XM_005216831.3|",1958,0,"PREDICTED: Bos taurus epoxide hydrolase 1 (EPHX1), transcript variant X1, mRNA","P79381",827,0,"Epoxide hydrolase 1","CAC0719",289,{"v":9e-90,"d":"9.00E-90"},"COG0596","pfam06441","EHN","Epoxide hydrolase N terminus. This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyse the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organisms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.","GO:0019439|aromatic compound catabolic process;GO:0009636|response to toxic substance;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031090|organelle membrane;","GO:0033961|cis-stilbene-oxide hydrolase activity;","K01253","EPHX1; microsomal epoxide hydrolase [EC:3.3.2.9]"]
["gene20247",4511,1632,2206,2388.01699757278,8075,4002,6316,6766.76634280937,0.352903717461794,-1.50265346744626,0.00231285226495174,0.0342438961968542,"down","yes","PRRX1","protein_coding","chrNC_037343.1:38199869-38278011:+","gi|126165288|ref|NP_001075208.1|",1202,{"v":3e-149,"d":"3.00E-149"},"paired mesoderm homeobox protein 1 [Bos taurus]","gi|982947830|ref|XM_010813225.2|",4447,0,"PREDICTED: Bos taurus paired related homeobox 1 (PRRX1), transcript variant X1, mRNA","P63014",463,{"v":3e-149,"d":"3.00E-149"},"Paired mesoderm homeobox protein 1","ECU03g1170",52.8,{"v":2e-06,"d":"2.00E-06"},"COG5576","pfam00046","Homeobox","Homeobox domain.","GO:0048844|artery morphogenesis;GO:0051216|cartilage development;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0030326|embryonic limb morphogenesis;GO:0042472|inner ear morphogenesis;GO:0042474|middle ear morphogenesis;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0048664|neuron fate determination;GO:0097150|neuronal stem cell population maintenance;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0045880|positive regulation of smoothened signaling pathway;GO:0070570|regulation of neuron projection regeneration;GO:0060021|palate development;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0071837|HMG box domain binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001105|RNA polymerase II transcription coactivator activity;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09329","PRRX, PMX; paired mesoderm homeobox protein"]
["gene20250",12,4,8,6.89532262772572,27,87,80,70.8974880133328,0.0972576436901262,-3.36204455067343,{"v":9.40312365548728e-05,"d":"9.40E-05"},0.00276577856716193,"down","yes","FMO3","protein_coding","chrNC_037343.1:38649500-38676494:+","gi|74355026|gb|AAI02684.1|",2141,0,"FMO3 protein [Bos taurus]","gi|942074498|ref|XM_005902394.2|",1715,0,"PREDICTED: Bos mutus flavin containing monooxygenase 3 (FMO3), transcript variant X2, mRNA","Q8HYJ9",810,0,"Dimethylaniline monooxygenase [N-oxide-forming] 3","CC0774",157,{"v":7e-41,"d":"7.00E-41"},"COG2072","pfam00743","FMO-like","Flavin-binding monooxygenase-like. This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.","GO:0055114|oxidation-reduction process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0031090|organelle membrane;","GO:0050660|flavin adenine dinucleotide binding;GO:0004497|monooxygenase activity;GO:0004499|N,N-dimethylaniline monooxygenase activity;GO:0050661|NADP binding;GO:0034899|trimethylamine monooxygenase activity;","K00485","FMO; dimethylaniline monooxygenase (N-oxide forming) [EC:1.14.13.8]"]
["gene204",379,219,191,229.206610526315,1070,421,719,813.973129840263,0.281589897901538,-1.82833251698025,0.000145240864945489,0.00397683984429919,"down","yes","VGLL3","protein_coding","chrNC_037328.1:35064358-35123321:-","gi|982909611|ref|XP_015324220.1|",1166,{"v":4e-141,"d":"4.00E-141"},"PREDICTED: transcription cofactor vestigial-like protein 3 isoform X2 [Bos taurus]","gi|982909610|ref|XM_015468734.1|",10555,0,"PREDICTED: Bos taurus vestigial like family member 3 (VGLL3), transcript variant X2, mRNA","A8MV65",373,{"v":7e-114,"d":"7.00E-114"},"Transcription cofactor vestigial-like protein 3",".",".",".",".","pfam07545","Vg_Tdu","Vestigial/Tondu family. The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Scalloped (Sd) interacts with Vestigial (Vg) to form a complex, which binds DNA through the Sd TEA/ATTS domain. The Sd-Vg heterodimer is a key regulator of wing development, which directly controls several target genes and is able to induce wing outgrowth when ectopically expressed. This short conserved region is needed for interaction with Sd.","GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;",".",".","."]
["gene20569",634,190,200,288.925817925031,611,587,564,647.382715187396,0.446298319598163,-1.1639197203208,0.00160086853260692,0.0261744298589157,"down","yes","ZBTB37","protein_coding","chrNC_037343.1:55238468-55266935:+","gi|440910104|gb|ELR59932.1|",2708,0,"Zinc finger and BTB domain-containing protein 37, partial [Bos mutus]","gi|742165090|ref|XM_010850077.1|",9807,0,"PREDICTED: Bison bison bison zinc finger and BTB domain containing 37 (ZBTB37), transcript variant X2, mRNA","Q5TC79",1021,0,"Zinc finger and BTB domain-containing protein 37",".",".",".",".","pfam00651","BTB","BTB/POZ domain. The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K10509","ZBTB37; zinc finger and BTB domain-containing protein 37"]
["gene2064",4670,3046,2822,3082.03581693045,6525,7969,7172,7952.2582817199,0.387567368632281,-1.36748098722561,{"v":1.15022247911412e-05,"d":"1.15E-05"},0.000484026512560545,"down","yes","AOX1","protein_coding","chrNC_037329.1:89102060-89173915:+","gi|75773740|gb|AAI05266.1|",6990,0,"Aldehyde oxidase 1 [Bos taurus]","gi|75773739|gb|BC105265.1|",4437,0,"Bos taurus aldehyde oxidase 1, mRNA (cDNA clone MGC:128959 IMAGE:8120672), complete cds","P48034",2699,0,"Aldehyde oxidase 1","PA1523",506,{"v":1e-157,"d":"1.00E-157"},"COG4631","pfam02738","Ald_Xan_dh_C2","Molybdopterin-binding domain of aldehyde dehydrogenase.","GO:0017144|drug metabolic process;GO:0055114|oxidation-reduction process;GO:0009115|xanthine catabolic process;","GO:0005829|cytosol;","GO:0051537|2 iron, 2 sulfur cluster binding;GO:0004031|aldehyde oxidase activity;GO:0009055|electron carrier activity;GO:0050660|flavin adenine dinucleotide binding;GO:0005506|iron ion binding;GO:0043546|molybdopterin cofactor binding;GO:0051287|NAD binding;GO:0016614|oxidoreductase activity, acting on CH-OH group of donors;GO:0016903|oxidoreductase activity, acting on the aldehyde or oxo group of donors;GO:0042803|protein homodimerization activity;GO:0050250|retinal oxidase activity;GO:0004854|xanthine dehydrogenase activity;","K00157","AOX; aldehyde oxidase [EC:1.2.3.1]"]
["gene20715",1680,702,1792,1218.26681611358,2212,2318,2315,2513.10443717575,0.484765693813616,-1.04464048996307,0.000595645031973726,0.0121301558938204,"down","yes","PROX1","protein_coding","chrNC_037343.1:69530598-69586099:-","gi|466035766|ref|XP_004275294.1|",3726,0,"PREDICTED: prospero homeobox protein 1 [Orcinus orca]","gi|982949016|ref|XM_005217353.3|",8278,0,"PREDICTED: Bos taurus prospero homeobox 1 (PROX1), transcript variant X1, mRNA","Q92786",1387,0,"Prospero homeobox protein 1",".",".",".",".","pfam05044","HPD","Homeo-prospero domain. Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.","GO:0090425|acinar cell differentiation;GO:0060414|aorta smooth muscle tissue morphogenesis;GO:0055009|atrial cardiac muscle tissue morphogenesis;GO:0007420|brain development;GO:0061114|branching involved in pancreas morphogenesis;GO:0055007|cardiac muscle cell differentiation;GO:0001709|cell fate determination;GO:0021707|cerebellar granule cell differentiation;GO:0007623|circadian rhythm;GO:0021542|dentate gyrus development;GO:0021516|dorsal spinal cord development;GO:0060059|embryonic retina morphogenesis in camera-type eye;GO:0060214|endocardium formation;GO:0002194|hepatocyte cell migration;GO:0070365|hepatocyte differentiation;GO:0072574|hepatocyte proliferation;GO:0001822|kidney development;GO:0002088|lens development in camera-type eye;GO:0070309|lens fiber cell morphogenesis;GO:0001889|liver development;GO:0030324|lung development;GO:0001946|lymphangiogenesis;GO:0060836|lymphatic endothelial cell differentiation;GO:0070858|negative regulation of bile acid biosynthetic process;GO:0008285|negative regulation of cell proliferation;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045071|negative regulation of viral genome replication;GO:0021915|neural tube development;GO:0030182|neuron differentiation;GO:0097150|neuronal stem cell population maintenance;GO:0030910|olfactory placode formation;GO:0046619|optic placode formation involved in camera-type eye formation;GO:0043049|otic placode formation;GO:0031016|pancreas development;GO:0045787|positive regulation of cell cycle;GO:1901978|positive regulation of cell cycle checkpoint;GO:0008284|positive regulation of cell proliferation;GO:0045737|positive regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0010595|positive regulation of endothelial cell migration;GO:0001938|positive regulation of endothelial cell proliferation;GO:2000979|positive regulation of forebrain neuron differentiation;GO:0060421|positive regulation of heart growth;GO:2000179|positive regulation of neural precursor cell proliferation;GO:0060298|positive regulation of sarcomere organization;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0042752|regulation of circadian rhythm;GO:0010468|regulation of gene expression;GO:0060849|regulation of transcription involved in lymphatic endothelial cell fate commitment;GO:0031667|response to nutrient levels;GO:0060042|retina morphogenesis in camera-type eye;GO:0030240|skeletal muscle thin filament assembly;GO:0006351|transcription, DNA-templated;GO:0048845|venous blood vessel morphogenesis;GO:0055010|ventricular cardiac muscle tissue morphogenesis;GO:0055005|ventricular cardiac myofibril assembly;GO:0060412|ventricular septum morphogenesis;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0001046|core promoter sequence-specific DNA binding;GO:0050692|DBD domain binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0050693|LBD domain binding;GO:0016922|ligand-dependent nuclear receptor binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003714|transcription corepressor activity;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0044212|transcription regulatory region DNA binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;",".","."]
["gene20779",10,6,9,7.33663314607458,80,119,90,106.060527885326,0.0691740206498598,-3.85362587614501,{"v":5.60881321211514e-08,"d":"5.61E-08"},{"v":5.03223426902066e-06,"d":"5.03E-06"},"down","yes","G0S2","protein_coding","chrNC_037343.1:73640793-73641791:-","gi|406356153|gb|AFS34515.1|",281,{"v":8e-28,"d":"8.00E-28"},"G0/G1 switch 2 protein [Bos taurus]","gi|982948989|ref|XM_005217335.3|",804,0,"PREDICTED: Bos taurus G0/G1 switch 2 (G0S2), transcript variant X1, mRNA","P27469",66.2,{"v":2e-12,"d":"2.00E-12"},"G0/G1 switch protein 2",".",".",".",".","pfam15103","G0-G1_switch_2","G0/G1 switch protein 2. This family of proteins regulate apoptosis by binding to Bcl-2 and preventing the formation of the anti-apoptotic BAX-BCL2 heterodimers.","GO:0097191|extrinsic apoptotic signaling pathway;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:0019216|regulation of lipid metabolic process;","GO:0005811|lipid particle;GO:0005739|mitochondrion;",".",".","."]
["gene20826",477,79,159,199.039320371882,470,406,389,465.086409004921,0.427962022794297,-1.22444531685267,0.00252119204491627,0.036347716136183,"down","yes","PTPRC","protein_coding","chrNC_037343.1:77540526-77670102:+","gi|528980913|ref|XP_005217387.1|",6698,0,"PREDICTED: receptor-type tyrosine-protein phosphatase C isoform X1 [Bos taurus]","gi|742233182|ref|XM_010831084.1|",4716,0,"PREDICTED: Bison bison bison protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant X2, mRNA","P08575",1598,0,"Receptor-type tyrosine-protein phosphatase C","SPAC26F1.10c",134,{"v":1e-31,"d":"1.00E-31"},"COG5599","pfam00102","Y_phosphatase","Protein-tyrosine phosphatase.","GO:0042100|B cell proliferation;GO:0050853|B cell receptor signaling pathway;GO:0048539|bone marrow development;GO:0044770|cell cycle phase transition;GO:0007166|cell surface receptor signaling pathway;GO:0051607|defense response to virus;GO:0016311|dephosphorylation;GO:0002244|hematopoietic progenitor cell differentiation;GO:0002378|immunoglobulin biosynthetic process;GO:0006933|negative regulation of cell adhesion involved in substrate-bound cell migration;GO:0001960|negative regulation of cytokine-mediated signaling pathway;GO:0006469|negative regulation of protein kinase activity;GO:0001915|negative regulation of T cell mediated cytotoxicity;GO:0043312|neutrophil degranulation;GO:0050857|positive regulation of antigen receptor-mediated signaling pathway;GO:0030890|positive regulation of B cell proliferation;GO:2000473|positive regulation of hematopoietic stem cell migration;GO:0045860|positive regulation of protein kinase activity;GO:2000648|positive regulation of stem cell proliferation;GO:0042102|positive regulation of T cell proliferation;GO:0006470|protein dephosphorylation;GO:0051726|regulation of cell cycle;GO:0051209|release of sequestered calcium ion into cytosol;GO:0048864|stem cell development;GO:0030217|T cell differentiation;GO:0050852|T cell receptor signaling pathway;","GO:0009986|cell surface;GO:0009897|external side of plasma membrane;GO:0070062|extracellular exosome;GO:0005925|focal adhesion;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0045121|membrane raft;GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;","GO:0019901|protein kinase binding;GO:0004725|protein tyrosine phosphatase activity;GO:0005001|transmembrane receptor protein tyrosine phosphatase activity;","K06478","PTPRC, CD45; receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]"]
["gene20862",4141,6714,8964,6032.57564559483,17421,8734,15169,15192.2810716119,0.397081624356412,-1.33249249570535,0.00388644731045479,0.0497824881091149,"down","yes","CYB5R1","protein_coding","chrNC_037343.1:79860414-79865628:+","gi|77735983|ref|NP_001029690.1|",1474,0,"NADH-cytochrome b5 reductase 1 [Bos taurus]","gi|77735982|ref|NM_001034518.1|",1577,0,"Bos taurus cytochrome b5 reductase 1 (CYB5R1), mRNA","Q3MHW9",572,0,"NADH-cytochrome b5 reductase 1","SPCC970.03",206,{"v":2e-60,"d":"2.00E-60"},"COG0543","pfam00970","FAD_binding_6","Oxidoreductase FAD-binding domain.","GO:0016126|sterol biosynthetic process;","GO:0016021|integral component of membrane;","GO:0004128|cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0016491|oxidoreductase activity;","K00326","E1.6.2.2; cytochrome-b5 reductase [EC:1.6.2.2]"]
["gene20900",32451,13677,47875,27643.1275660683,78344,72467,77616,83894.2471295894,0.329499679797693,-1.60165103164038,0.00222279298141483,0.0332556405625309,"down","yes","TNNI1","protein_coding","chrNC_037343.1:80895145-80907893:+","gi|594033593|ref|XP_006041529.1|",1050,{"v":2e-140,"d":"2.00E-140"},"PREDICTED: troponin I, slow skeletal muscle isoform X3 [Bubalus bubalis]","gi|982948031|ref|XM_010813396.2|",1043,0,"PREDICTED: Bos taurus troponin I type 1 (skeletal, slow) (TNNI1), transcript variant X5, mRNA","P19237",306,{"v":3e-102,"d":"3.00E-102"},"Troponin I, slow skeletal muscle",".",".",".",".","pfam00992","Troponin","Troponin. Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.","GO:0060048|cardiac muscle contraction;GO:0030049|muscle filament sliding;GO:0006942|regulation of striated muscle contraction;GO:0003009|skeletal muscle contraction;GO:0014883|transition between fast and slow fiber;GO:0055010|ventricular cardiac muscle tissue morphogenesis;","GO:0005829|cytosol;GO:0005861|troponin complex;","GO:0003779|actin binding;GO:0046872|metal ion binding;","K10371","TNNI1; troponin I, slow skeletal muscle"]
["gene20927",0,9,7,5.09931054811604,11,106,62,65.3924503890158,0.077980111125681,-3.68074997912285,0.000814753462868604,0.0155074923609767,"down","yes","FGA","protein_coding","chrNC_037344.1:2860738-2868865:+","gi|741955615|ref|XP_005217494.2|",4181,0,"PREDICTED: fibrinogen alpha chain isoform X1 [Bos taurus]","gi|982949489|ref|XM_005217437.3|",2782,0,"PREDICTED: Bos taurus fibrinogen alpha chain (FGA), transcript variant X1, mRNA","P02672",1112,0,"Fibrinogen alpha chain",".",".",".",".","pfam00147","Fibrinogen_C","Fibrinogen beta and gamma chains, C-terminal globular domain.","GO:0002250|adaptive immune response;GO:0045087|innate immune response;GO:0030168|platelet activation;GO:0051258|protein polymerization;","GO:0005577|fibrinogen complex;","GO:0005102|receptor binding;","K03903","FGA; fibrinogen alpha chain"]
["gene20930",4,3,1,2.33276761857272,19,36,26,29.6984412969171,0.0785484866108066,-3.67027271031021,0.000718463411798294,0.0140786261002865,"down","yes","LOC107133268","protein_coding","chrNC_037344.1:3009266-3011829:+","gi|982949511|ref|XP_015330812.1|",3013,0,"PREDICTED: protocadherin-16-like [Bos taurus]","gi|982997431|ref|XM_015466993.1|",2537,0,"PREDICTED: Bos taurus protocadherin-16-like (LOC107133268), mRNA","E9PVD3",311,{"v":3e-87,"d":"3.00E-87"},"Protocadherin-16",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0001658|branching involved in ureteric bud morphogenesis;GO:0016477|cell migration;GO:0003273|cell migration involved in endocardial cushion formation;GO:0098609|cell-cell adhesion;GO:0090102|cochlea development;GO:0072137|condensed mesenchymal cell proliferation;GO:0048565|digestive tract development;GO:0001736|establishment of planar polarity;GO:0003007|heart morphogenesis;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0035329|hippo signaling;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0001822|kidney development;GO:0003192|mitral valve formation;GO:0003183|mitral valve morphogenesis;GO:0072006|nephron development;GO:0021915|neural tube development;GO:0022008|neurogenesis;GO:0043931|ossification involved in bone maturation;GO:0007389|pattern specification process;GO:0036342|post-anal tail morphogenesis;GO:0072659|protein localization to plasma membrane;","GO:0045177|apical part of cell;GO:0016021|integral component of membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;","K16507","DCHS1_2, PCDH16_23; protocadherin-16/23"]
["gene20931",33,12,2,13.1474222332903,101,68,123,107.105397079704,0.122752191689336,-3.02617931139742,0.000112661630444363,0.00319517791074367,"down","yes","DCHS2","protein_coding","chrNC_037344.1:3137604-3333575:+","gi|296478818|tpg|DAA20933.1|",13852,0,"TPA: dachsous 2-like [Bos taurus]","gi|742123396|ref|XM_010840797.1|",8530,0,"PREDICTED: Bison bison bison dachsous cadherin-related 2 (DCHS2), mRNA","Q6V1P9",3916,0,"Protocadherin-23",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;","K16507","DCHS1_2, PCDH16_23; protocadherin-16/23"]
["gene21034",317,253,268,247.838736723318,560,494,489,567.117732037956,0.437014613936865,-1.19424657007746,0.00031260244442046,0.00724759238403271,"down","yes","ZNF330","protein_coding","chrNC_037344.1:16533915-16553609:-","gi|803171268|ref|XP_004017280.2|",1477,0,"PREDICTED: zinc finger protein 330 isoform X1 [Ovis aries]","gi|982949781|ref|XM_010813746.2|",1828,0,"PREDICTED: Bos taurus zinc finger protein 330 (ZNF330), transcript variant X1, mRNA","Q32LC9",566,0,"Zinc finger protein 330",".",".",".",".","pfam06524","NOA36","NOA36 protein. This family consists of several NOA36 proteins which contain 29 highly conserved cysteine residues. The function of this protein is unknown.",".","GO:0000775|chromosome, centromeric region;GO:0005730|nucleolus;","GO:0008270|zinc ion binding;",".","."]
["gene21056",557,495,612,495.345833893191,1702,754,1291,1378.87791550585,0.359238354841204,-1.47698670420376,0.000581778153369594,0.0118987186335397,"down","yes","RAB33B","protein_coding","chrNC_037344.1:18245542-18265684:-","gi|742229951|ref|XP_010828590.1|",1604,0,"PREDICTED: ras-related protein Rab-33B isoform X1 [Bison bison bison]","gi|742229950|ref|XM_010830288.1|",3230,0,"PREDICTED: Bison bison bison RAB33B, member RAS oncogene family (RAB33B), transcript variant X1, mRNA","Q5R615",429,{"v":2e-140,"d":"2.00E-140"},"Ras-related protein Rab-33B",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0000045|autophagosome assembly;GO:0006891|intra-Golgi vesicle-mediated transport;GO:1903434|negative regulation of constitutive secretory pathway;GO:0034067|protein localization to Golgi apparatus;GO:0015031|protein transport;GO:1903358|regulation of Golgi organization;GO:2000156|regulation of retrograde vesicle-mediated transport, Golgi to ER;GO:0048705|skeletal system morphogenesis;","GO:0005796|Golgi lumen;GO:0000139|Golgi membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07920","RAB33B; Ras-related protein Rab-33B"]
["gene21074",628,237,364,353.132757338452,810,569,650,746.200457299357,0.473241143025437,-1.07935258955605,0.000948321641109983,0.0173115747553657,"down","yes","PCDH18","protein_coding","chrNC_037344.1:20287884-20302108:+","gi|528981623|ref|XP_005217626.1|",5809,0,"PREDICTED: protocadherin-18 isoform X1 [Bos taurus]","gi|742229871|ref|XM_010830266.1|",5189,0,"PREDICTED: Bison bison bison protocadherin 18 (PCDH18), transcript variant X1, mRNA","A7MB46",2231,0,"Protocadherin-18",".",".",".",".","pfam00028","Cadherin","Cadherin domain.","GO:0007420|brain development;GO:0007155|cell adhesion;GO:0007267|cell-cell signaling;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007399|nervous system development;","GO:0005887|integral component of plasma membrane;","GO:0005509|calcium ion binding;","K16499","PCDHD2; protocadherin delta 2"]
["gene21236",38,18,34,26.2447367681701,124,122,114,132.270635883307,0.198416954699786,-2.33339278581478,{"v":2.57024868667222e-05,"d":"2.57E-05"},0.000924738528114061,"down","yes","RIMBP2","protein_coding","chrNC_037344.1:46382992-46716250:+","gi|982950144|ref|XP_003587190.4|",5600,0,"PREDICTED: RIMS-binding protein 2 isoform X4 [Bos taurus]","gi|982998001|ref|XM_015467101.1|",6447,0,"PREDICTED: Bos taurus RIMS binding protein 2 (RIMBP2), transcript variant X4, mRNA","O15034",1724,0,"RIMS-binding protein 2",".",".",".",".","pfam14604","SH3_9","Variant SH3 domain.","GO:0010923|negative regulation of phosphatase activity;","GO:0030054|cell junction;GO:0005886|plasma membrane;GO:0045202|synapse;",".","K17591","RIMBP2; RIMS-binding protein 2"]
["gene21304",51,54,60,49.4158377722888,290,161,236,252.667346435882,0.195576668173973,-2.35419382437965,{"v":2.67926490625394e-06,"d":"2.68E-06"},0.000138482077971614,"down","yes","CCDC62","protein_coding","chrNC_037344.1:52702533-52745673:-","gi|741956808|ref|XP_010812318.1|",3359,0,"PREDICTED: coiled-coil domain-containing protein 62 isoform X3 [Bos taurus]","gi|982998158|ref|XM_010823369.2|",2828,0,"PREDICTED: Bos taurus coiled-coil domain containing 62 (CCDC62), transcript variant X3, mRNA","Q6P9F0",1031,0,"Coiled-coil domain-containing protein 62",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0071392|cellular response to estradiol stimulus;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0030331|estrogen receptor binding;GO:0030374|ligand-dependent nuclear receptor transcription coactivator activity;",".","."]
["gene2136",138,73,21,66.3389515712485,227,266,265,278.12186526327,0.238524761469049,-2.06778905341839,{"v":3.03506809095463e-05,"d":"3.04E-05"},0.00107046222714526,"down","yes","GPR1","protein_coding","chrNC_037329.1:94500791-94556999:-","gi|528939918|ref|XP_005202775.1|",1843,0,"PREDICTED: G-protein coupled receptor 1 isoform X1 [Bos taurus]","gi|982914415|ref|XM_005202719.3|",2677,0,"PREDICTED: Bos taurus G protein-coupled receptor 1 (GPR1), transcript variant X3, mRNA","O97664",578,0,"G-protein coupled receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0007268|synaptic transmission;GO:0007187|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007218|neuropeptide signaling pathway;","GO:0005887|integral component of plasma membrane;GO:0043005|neuron projection;GO:0005654|nucleoplasm;","GO:0004930|G-protein coupled receptor activity;GO:0042923|neuropeptide binding;","K04310","GPR1; G protein-coupled receptor 1"]
["gene21426",0,1,0,0.327717679206592,7,20,21,17.5365586686011,0.0186876847048312,-5.7417683511234,0.000520013729102584,0.0108692393443413,"down","yes","SDSL","protein_coding","chrNC_037344.1:61005840-61017877:-","gi|154707848|ref|NP_001092465.1|",1424,0,"serine dehydratase-like [Bos taurus]","gi|742219447|ref|XM_010828563.1|",1374,0,"PREDICTED: Bison bison bison serine dehydratase-like (SDSL), transcript variant X2, mRNA","Q96GA7",441,{"v":1e-151,"d":"1.00E-151"},"Serine dehydratase-like","YCL064c",133,{"v":7e-34,"d":"7.00E-34"},"COG1171","pfam00291","PALP","Pyridoxal-phosphate dependent enzyme. Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.","GO:0019518|L-threonine catabolic process to glycine;","GO:0005829|cytosol;","GO:0016836|hydro-lyase activity;GO:0042802|identical protein binding;GO:0003941|L-serine ammonia-lyase activity;GO:0004794|L-threonine ammonia-lyase activity;GO:0030170|pyridoxal phosphate binding;","K17989","SDS, SDH, CHA1; L-serine/L-threonine ammonia-lyase [EC:4.3.1.17 4.3.1.19]"]
["gene21451",592,466,525,468.244252361562,1641,828,1325,1395.5082203172,0.335536720991245,-1.5754574319106,0.000140771861033746,0.00386912972137609,"down","yes","TRAFD1","protein_coding","chrNC_037344.1:62027368-62046875:-","gi|115305334|gb|AAI23487.1|",2811,0,"TRAF-type zinc finger domain containing 1 [Bos taurus]","gi|742219573|ref|XM_010828597.1|",2680,0,"PREDICTED: Bison bison bison TRAF-type zinc finger domain containing 1 (TRAFD1), transcript variant X1, mRNA","Q58D05",1085,0,"TRAF-type zinc finger domain-containing protein 1",".",".",".",".","pfam02176","zf-TRAF","TRAF-type zinc finger.","GO:0045824|negative regulation of innate immune response;GO:0034097|response to cytokine;",".","GO:0046872|metal ion binding;",".","."]
["gene21524",0,0,0,0,0,32,6,13.9094395383817,{"$error":"#NAME?"},{"$error":"#NAME?"},0.00139127689452264,0.0235017886782862,"down","yes","DAO","protein_coding","chrNC_037344.1:64095347-64114577:-","gi|982950425|ref|XP_015330977.1|",1870,0,"PREDICTED: D-amino-acid oxidase isoform X1 [Bos taurus]","gi|594041074|ref|XM_006045027.1|",2429,0,"PREDICTED: Bubalus bubalis D-amino-acid oxidase (DAO), mRNA","P00371",650,0,"D-amino-acid oxidase","ML2011",136,{"v":2e-33,"d":"2.00E-33"},"COG0665","pfam01266","DAO","FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.","GO:0046416|D-amino acid metabolic process;GO:0055114|oxidation-reduction process;","GO:0005777|peroxisome;","GO:0003884|D-amino-acid oxidase activity;GO:0071949|FAD binding;","K00273","DAO, aao; D-amino-acid oxidase [EC:1.4.3.3]"]
["gene21540",64,87,80,69.7610559371391,363,105,288,278.171703355538,0.250784156316488,-1.99548188839672,0.000544117338384367,0.0112494288271336,"down","yes","SGSM1","protein_coding","chrNC_037344.1:65010748-65084808:+","gi|528989258|ref|XP_005218117.1|",5802,0,"PREDICTED: small G protein signaling modulator 1 isoform X1 [Bos taurus]","gi|982950758|ref|XM_005218060.3|",5558,0,"PREDICTED: Bos taurus small G protein signaling modulator 1 (SGSM1), transcript variant X1, mRNA","Q2NKQ1",2088,0,"Small G protein signaling modulator 1","SPAC630.05",120,{"v":1e-26,"d":"1.00E-26"},"COG5210","pfam02759","RUN","RUN domain. This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.","GO:0090630|activation of GTPase activity;GO:0006886|intracellular protein transport;GO:0031338|regulation of vesicle fusion;","GO:0005737|cytoplasm;GO:0030659|cytoplasmic vesicle membrane;GO:0005829|cytosol;GO:0012505|endomembrane system;GO:0005794|Golgi apparatus;","GO:0005096|GTPase activator activity;GO:0017137|Rab GTPase binding;",".","."]
["gene22078",314,154,185,189.121721181884,374,392,395,426.232683712039,0.443705347827464,-1.17232615331888,0.00087136772086406,0.0162308926488996,"down","yes","ADCY7","protein_coding","chrNC_037345.1:18655907-18720625:+","gi|27806333|ref|NP_776655.1|",5127,0,"adenylate cyclase type 7 [Bos taurus]","gi|31342538|ref|NM_174230.2|",6168,0,"Bos taurus adenylate cyclase 7 (ADCY7), mRNA","Q29450",1920,0,"Adenylate cyclase type 7","all0661",162,{"v":8e-41,"d":"8.00E-41"},"COG2114","pfam00211","Guanylate_cyc","Adenylate and Guanylate cyclase catalytic domain.","GO:0006171|cAMP biosynthetic process;GO:0006182|cGMP biosynthetic process;GO:0035556|intracellular signal transduction;GO:0007165|signal transduction;","GO:0008074|guanylate cyclase complex, soluble;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0004383|guanylate cyclase activity;GO:0046872|metal ion binding;","K08047","ADCY7; adenylate cyclase 7 [EC:4.6.1.1]"]
["gene22083",1613,1292,1555,1321.37066281232,7707,2349,5526,5737.42065220372,0.230307440034885,-2.11836707703469,{"v":2.87414861448057e-06,"d":"2.87E-06"},0.00014775195336891,"down","yes","CYLD","protein_coding","chrNC_037345.1:19131308-19204355:+","gi|114051812|ref|NP_001039882.1|",5094,0,"ubiquitin carboxyl-terminal hydrolase CYLD [Bos taurus]","gi|741958393|ref|XM_005218684.2|",7973,0,"PREDICTED: Bos taurus cylindromatosis (turban tumor syndrome) (CYLD), transcript variant X1, mRNA","Q1RMU2",1966,0,"Ubiquitin carboxyl-terminal hydrolase CYLD",".",".",".",".","pfam01302","CAP_GLY","CAP-Gly domain. Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove.","GO:0043369|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment;GO:0048872|homeostasis of number of cells;GO:0045087|innate immune response;GO:0070266|necroptotic process;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:1901223|negative regulation of NIK/NF-kappaB signaling;GO:0045581|negative regulation of T cell differentiation;GO:1903829|positive regulation of cellular protein localization;GO:2001238|positive regulation of extrinsic apoptotic signaling pathway;GO:0045582|positive regulation of T cell differentiation;GO:0050862|positive regulation of T cell receptor signaling pathway;GO:0070536|protein K63-linked deubiquitination;GO:1990108|protein linear deubiquitination;GO:0045577|regulation of B cell differentiation;GO:1902017|regulation of cilium assembly;GO:2001242|regulation of intrinsic apoptotic signaling pathway;GO:0070507|regulation of microtubule cytoskeleton organization;GO:0007346|regulation of mitotic cell cycle;GO:0043393|regulation of protein binding;GO:0010803|regulation of tumor necrosis factor-mediated signaling pathway;GO:1901026|ripoptosome assembly involved in necroptotic process;GO:0006511|ubiquitin-dependent protein catabolic process;GO:0016055|Wnt signaling pathway;","GO:0005813|centrosome;GO:0036064|ciliary basal body;GO:0097542|ciliary tip;GO:0005881|cytoplasmic microtubule;GO:0005829|cytosol;GO:0031234|extrinsic component of cytoplasmic side of plasma membrane;GO:0030496|midbody;GO:0048471|perinuclear region of cytoplasm;GO:0005819|spindle;","GO:1990380|Lys48-specific deubiquitinase activity;GO:0061578|Lys63-specific deubiquitinase activity;GO:0070064|proline-rich region binding;GO:0019901|protein kinase binding;GO:0004843|ubiquitin-specific protease activity;GO:0008270|zinc ion binding;","K08601","CYLD, USLP2; ubiquitin thioesterase CYLD [EC:3.4.19.12]"]
["gene22155",934,1235,1257,1034.20533047055,1908,1783,2027,2099.18039647566,0.492671012080186,-1.02130350644909,0.000296047948846324,0.00692907631545076,"down","yes","FAM192A","protein_coding","chrNC_037345.1:25169954-25212549:-","gi|675751335|ref|XP_008984171.1|",866,{"v":7e-102,"d":"7.00E-102"},"PREDICTED: protein FAM192A [Callithrix jacchus]","gi|982951745|ref|XM_015475762.1|",2915,0,"PREDICTED: Bos taurus family with sequence similarity 192 member A (FAM192A), transcript variant X3, mRNA","Q91WE2",323,{"v":4e-98,"d":"4.00E-98"},"Protein FAM192A",".",".",".",".","pfam10187","Nefa_Nip30_N","N-terminal domain of NEFA-interacting nuclear protein NIP30. This is a the N-terminal 100 amino acids of a family of proteins conserved from plants to humans. The full-length protein has putatively been called NEFA-interacting nuclear protein NIP30, however no reference could be found to confirm this.",".","GO:0005634|nucleus;",".",".","."]
["gene22161",7,0,2,2.43860592506968,31,35,34,36.7044539177722,0.0664389648878256,-3.91182659333828,0.00100178772372056,0.0181013334676828,"down","yes","CCL22","protein_coding","chrNC_037345.1:25365289-25373329:+","gi|426242421|ref|XP_004015071.1|",385,{"v":6e-41,"d":"6.00E-41"},"PREDICTED: C-C motif chemokine 22 [Ovis aries]","gi|402746724|ref|NM_001099162.2|",2012,0,"Bos taurus chemokine (C-C motif) ligand 22 (CCL22), mRNA","O88430",120,{"v":2e-30,"d":"2.00E-30"},"C-C motif chemokine 22",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0071346|cellular response to interferon-gamma;GO:0071347|cellular response to interleukin-1;GO:0071356|cellular response to tumor necrosis factor;GO:0070098|chemokine-mediated signaling pathway;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006954|inflammatory response;GO:0048247|lymphocyte chemotaxis;GO:0002548|monocyte chemotaxis;GO:0030593|neutrophil chemotaxis;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0043547|positive regulation of GTPase activity;","GO:0005615|extracellular space;","GO:0048020|CCR chemokine receptor binding;GO:0008009|chemokine activity;",".","."]
["gene22188",307,80,342,211.264346739215,341,502,443,471.593667970532,0.447979608480273,-1.15849503093914,0.00214150778486831,0.0323448166278866,"down","yes","NDRG4","protein_coding","chrNC_037345.1:26255416-26298412:+","gi|528990517|ref|XP_005218639.1|",2088,0,"PREDICTED: protein NDRG4 isoform X2 [Bos taurus]","gi|982951637|ref|XM_005218582.3|",3285,0,"PREDICTED: Bos taurus NDRG family member 4 (NDRG4), transcript variant X2, mRNA","Q6DIX1",714,0,"Protein NDRG4",".",".",".",".","pfam03096","Ndr","Ndr family. This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).","GO:0007420|brain development;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;",".",".","."]
["gene22236",829,743,769,695.727435232347,1724,1046,1494,1567.53867999084,0.443834301579347,-1.17190692486012,0.00107176227100825,0.0190757637892305,"down","yes","CBFB","protein_coding","chrNC_037345.1:34704537-34753112:+","gi|528990791|ref|XP_005218775.1|",796,{"v":7e-96,"d":"7.00E-96"},"PREDICTED: core-binding factor subunit beta isoform X1 [Bos taurus]","gi|982951787|ref|XM_005218718.3|",2962,0,"PREDICTED: Bos taurus core-binding factor, beta subunit (CBFB), transcript variant X1, mRNA","Q08024",306,{"v":2e-95,"d":"2.00E-95"},"Core-binding factor subunit beta",".",".",".",".","pfam02312","CBF_beta","Core binding factor beta subunit. Core binding factor (CBF) is a heterodimeric transcription factor essential for genetic regulation of hematopoiesis and osteogenesis. The beta subunit enhances DNA-binding ability of the alpha subunit in vitro, and has been show to have a structure related to the OB fold.","GO:0048469|cell maturation;GO:0060216|definitive hemopoiesis;GO:0030098|lymphocyte differentiation;GO:0030099|myeloid cell differentiation;GO:0043371|negative regulation of CD4-positive, alpha-beta T cell differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0001503|ossification;GO:0001649|osteoblast differentiation;GO:0043378|positive regulation of CD8-positive, alpha-beta T cell differentiation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0000209|protein polyubiquitination;","GO:0016513|core-binding factor complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;","GO:0003677|DNA binding;GO:0003713|transcription coactivator activity;",".","."]
["gene22288",265,348,344,288.760752086677,980,437,837,828.800603664937,0.34840798958131,-1.52115038714698,0.000556754006833705,0.0114497537622849,"down","yes","DUS2","protein_coding","chrNC_037345.1:35468636-35511695:+","gi|115495449|ref|NP_001068887.1|",2493,0,"tRNA-dihydrouridine(20) synthase [NAD(P)+]-like [Bos taurus]","gi|982951565|ref|XM_010814448.2|",1816,0,"PREDICTED: Bos taurus dihydrouridine synthase 2 (DUS2), transcript variant X2, mRNA","Q9NX74",900,0,"tRNA-dihydrouridine(20) synthase [NAD(P)+]-like","SPBC1709.06",212,{"v":1e-58,"d":"1.00E-58"},"COG0042","pfam01207","Dus","Dihydrouridine synthase (Dus). Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archae. Most dihydrouridines are found in the D loop of t-RNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap. Dus 1 from Saccharomyces cerevisiae acts on pre-tRNA-Phe, while Dus 2 acts on pre-tRNA-Tyr and pre-tRNA-Leu. Dus 1 is active as a single subunit, requiring NADPH or NADH, and is stimulated by the presence of FAD. Some family members may be targeted to the mitochondria and even have a role in mitochondria.","GO:0060548|negative regulation of cell death;","GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;","GO:0003725|double-stranded RNA binding;GO:0050660|flavin adenine dinucleotide binding;GO:0004860|protein kinase inhibitor activity;GO:0017150|tRNA dihydrouridine synthase activity;","K05543","DUS2; tRNA-dihydrouridine synthase 2 [EC:1.3.1.91]"]
["gene22349",0,17,13,9.56378178341738,33,76,71,65.8544772994791,0.145225991847528,-2.78362841184502,0.000802947624137117,0.0153339348488997,"down","yes","HP","protein_coding","chrNC_037345.1:39037405-39043561:-","gi|94966763|ref|NP_001035560.1|",2058,0,"haptoglobin precursor [Bos taurus]","gi|402743675|ref|NM_001040470.2|",1352,0,"Bos taurus haptoglobin (HP), mRNA","Q2TBU0",797,0,"Haptoglobin","mlr3307",52.4,{"v":1e-06,"d":"1.00E-06"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0006953|acute-phase response;GO:0042742|defense response to bacterium;GO:0002376|immune system process;","GO:0005615|extracellular space;","GO:0016209|antioxidant activity;GO:0030492|hemoglobin binding;","K16142","HP; haptoglobin"]
["gene22416",23,45,35,31.490887187813,104,63,108,100.977170178513,0.311861454744093,-1.6810228444708,0.00201130962336153,0.0309058065470859,"down","yes","CEBPA","protein_coding","chrNC_037345.1:43728248-43729478:-","gi|512994734|ref|XP_004858973.1|",1036,{"v":1e-133,"d":"1.00E-133"},"PREDICTED: CCAAT/enhancer-binding protein alpha [Heterocephalus glaber]","gi|67772261|gb|DQ068270.1|",1225,0,"Bos taurus C/EBP alpha protein gene, complete cds","O02754",381,{"v":3e-128,"d":"3.00E-128"},"CCAAT/enhancer-binding protein alpha",".",".",".",".","pfam07716","bZIP_2","Basic region leucine zipper.","GO:0045444|fat cell differentiation;GO:0042593|glucose homeostasis;GO:0030851|granulocyte differentiation;GO:0055088|lipid homeostasis;GO:0001889|liver development;GO:0030324|lung development;GO:0008285|negative regulation of cell proliferation;GO:0045892|negative regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0042803|protein homodimerization activity;GO:0003713|transcription coactivator activity;GO:0044212|transcription regulatory region DNA binding;",".","."]
["gene22519",190,155,169,152.218211355671,270,336,296,331.073182512532,0.459772096913676,-1.12100918182338,0.0021265426213885,0.0321528285801989,"down","yes","WDR62","protein_coding","chrNC_037345.1:46717363-46769693:+","gi|297485521|ref|XP_002694993.1|",7373,0,"PREDICTED: WD repeat-containing protein 62 isoform X1 [Bos taurus]","gi|594090854|ref|XM_006068762.1|",5633,0,"PREDICTED: Bubalus bubalis WD repeat domain 62 (WDR62), mRNA","Q8HXL3",2391,0,"WD repeat-containing protein 62",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.","GO:0021987|cerebral cortex development;GO:0007052|mitotic spindle organization;GO:0022008|neurogenesis;GO:0008380|RNA splicing;","GO:0071013|catalytic step 2 spliceosome;GO:0005814|centriole;GO:0005634|nucleus;GO:0071011|precatalytic spliceosome;GO:0000922|spindle pole;GO:0005682|U5 snRNP;","GO:0003723|RNA binding;",".","."]
["gene22583",66,56,37,46.9168241102589,112,127,125,133.591058419022,0.351197338096532,-1.50964618489303,0.00217086067006376,0.0326843407797304,"down","yes","RASGRP4","protein_coding","chrNC_037345.1:48215440-48229190:-","gi|164451486|ref|NP_001030456.2|",3141,0,"RAS guanyl-releasing protein 4 [Bos taurus]","gi|742161897|ref|XM_010849190.1|",2226,0,"PREDICTED: Bison bison bison RAS guanyl releasing protein 4 (RASGRP4), transcript variant X2, mRNA","Q1LZ97",1220,0,"RAS guanyl-releasing protein 4",".",".",".",".","pfam00617","RasGEF","RasGEF domain. Guanine nucleotide exchange factor for Ras-like small GTPases.","GO:0030154|cell differentiation;GO:0008283|cell proliferation;GO:0046579|positive regulation of Ras protein signal transduction;GO:0009991|response to extracellular stimulus;GO:0007264|small GTPase mediated signal transduction;","GO:0005737|cytoplasm;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0005088|Ras guanyl-nucleotide exchange factor activity;","K12363","RASGRP4; RAS guanyl-releasing protein 4"]
["gene22690",1059,889,1202,936.501228221146,1907,1851,2040,2128.45443062665,0.439991204296267,-1.18445341123967,{"v":4.15539245156135e-05,"d":"4.16E-05"},0.00138018046607098,"down","yes","AXL","protein_coding","chrNC_037345.1:50402734-50437829:+","gi|742162130|ref|XP_010847561.1|",4414,0,"PREDICTED: tyrosine-protein kinase receptor UFO isoform X1 [Bison bison bison]","gi|594055828|ref|XM_006052070.1|",4352,0,"PREDICTED: Bubalus bubalis AXL receptor tyrosine kinase (AXL), mRNA","P30530",1538,0,"Tyrosine-protein kinase receptor UFO","YAR019c",89.4,{"v":6e-17,"d":"6.00E-17"},"COG0515","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0031100|organ regeneration;GO:0043277|apoptotic cell clearance;GO:0001974|blood vessel remodeling;GO:0048469|cell maturation;GO:0031668|cellular response to extracellular stimulus;GO:0070301|cellular response to hydrogen peroxide;GO:0035457|cellular response to interferon-alpha;GO:0071222|cellular response to lipopolysaccharide;GO:0097028|dendritic cell differentiation;GO:0034101|erythrocyte homeostasis;GO:0021885|forebrain cell migration;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0001779|natural killer cell differentiation;GO:2000669|negative regulation of dendritic cell apoptotic process;GO:0032689|negative regulation of interferon-gamma production;GO:0051250|negative regulation of lymphocyte activation;GO:0043524|negative regulation of neuron apoptotic process;GO:0032720|negative regulation of tumor necrosis factor production;GO:0001764|neuron migration;GO:0097350|neutrophil clearance;GO:0042698|ovulation cycle;GO:0006909|phagocytosis;GO:0030168|platelet activation;GO:0001961|positive regulation of cytokine-mediated signaling pathway;GO:0032825|positive regulation of natural killer cell differentiation;GO:0048549|positive regulation of pinocytosis;GO:0051897|positive regulation of protein kinase B signaling;GO:0043491|protein kinase B signaling;GO:0032940|secretion by cell;GO:0007165|signal transduction;GO:0007283|spermatogenesis;GO:0034446|substrate adhesion-dependent cell spreading;GO:0060068|vagina development;GO:0048010|vascular endothelial growth factor receptor signaling pathway;GO:0046718|viral entry into host cell;","GO:0009986|cell surface;GO:0070062|extracellular exosome;GO:0005615|extracellular space;GO:0044228|host cell surface;GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0032036|myosin heavy chain binding;GO:0043548|phosphatidylinositol 3-kinase binding;GO:0001786|phosphatidylserine binding;GO:0046982|protein heterodimerization activity;GO:0004713|protein tyrosine kinase activity;GO:0004714|transmembrane receptor protein tyrosine kinase activity;GO:0001618|virus receptor activity;","K05115","AXL, UFO; AXL receptor tyrosine kinase [EC:2.7.10.1]"]
["gene22711",295,520,402,370.759944764567,1295,1261,1499,1487.89936107652,0.249183482743292,-2.00471965314701,{"v":1.15971928975236e-09,"d":"1.16E-09"},{"v":1.52479037124077e-07,"d":"1.52E-07"},"down","yes","LIPE","protein_coding","chrNC_037345.1:50886651-50907201:+","gi|440894149|gb|ELR46679.1|",4890,0,"Hormone-sensitive lipase, partial [Bos mutus]","gi|982953365|ref|XM_010815001.2|",2721,0,"PREDICTED: Bos taurus lipase, hormone-sensitive (LIPE), transcript variant X2, mRNA","P16386",1408,0,"Hormone-sensitive lipase","TVN0727",88.2,{"v":9e-18,"d":"9.00E-18"},"COG0657","pfam06350","HSL_N","Hormone-sensitive lipase (HSL) N-terminus. This family consists of several mammalian hormone-sensitive lipase (HSL) proteins (EC:3.1.1.-). Hormone-sensitive lipase, a key enzyme in fatty acid mobilisation, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin.","GO:0008203|cholesterol metabolic process;GO:0016042|lipid catabolic process;GO:0006363|termination of RNA polymerase I transcription;GO:0006361|transcription initiation from RNA polymerase I promoter;GO:0019433|triglyceride catabolic process;","GO:0005901|caveola;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005811|lipid particle;GO:0005739|mitochondrion;GO:0005634|nucleus;","GO:0033878|hormone-sensitive lipase activity;GO:0016298|lipase activity;GO:0042134|rRNA primary transcript binding;","K07188","LIPE, HSL; hormone-sensitive lipase [EC:3.1.1.79]"]
["gene22863",69,61,57,55.4797148889625,406,171,335,335.430636544094,0.165398472425071,-2.59598218465236,{"v":2.31987451308497e-06,"d":"2.32E-06"},0.000123485708456767,"down","yes","HIF3A","protein_coding","chrNC_037345.1:53558986-53590524:+","gi|741959915|ref|XP_010813318.1|",3085,0,"PREDICTED: hypoxia-inducible factor 3-alpha isoform X1 [Bos taurus]","gi|982953425|ref|XM_010815016.2|",5647,0,"PREDICTED: Bos taurus hypoxia inducible factor 3, alpha subunit (HIF3A), transcript variant X1, mRNA","Q9Y2N7",1013,0,"Hypoxia-inducible factor 3-alpha",".",".",".",".","pfam14598","PAS_11","PAS domain. This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).","GO:0001525|angiogenesis;GO:0006915|apoptotic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0043687|post-translational protein modification;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0061418|regulation of transcription from RNA polymerase II promoter in response to hypoxia;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005829|cytosol;GO:0005739|mitochondrion;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0003677|DNA binding;GO:0046983|protein dimerization activity;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003713|transcription coactivator activity;GO:0003714|transcription corepressor activity;","K09096","HIF3A; hypoxia-inducible factor 3 alpha"]
["gene22878",197,285,327,245.171090420462,570,410,512,548.330833579116,0.447122567994505,-1.16125772880537,0.000391631640900168,0.00867518815723813,"down","yes","SLC1A5","protein_coding","chrNC_037345.1:53864326-53875875:-","gi|440901774|gb|ELR52660.1|",2281,0,"Neutral amino acid transporter B(0), partial [Bos mutus]","gi|31341563|ref|NM_174601.2|",2863,0,"Bos taurus solute carrier family 1 (neutral amino acid transporter), member 5 (SLC1A5), mRNA","Q95JC7",873,0,"Neutral amino acid transporter B(0)","aq_1330",165,{"v":6e-43,"d":"6.00E-43"},"COG1301","pfam00375","SDF","Sodium:dicarboxylate symporter family.","GO:0006865|amino acid transport;","GO:0016021|integral component of membrane;GO:0042470|melanosome;GO:0005886|plasma membrane;","GO:0015293|symporter activity;","K05616","SLC1A5; solute carrier family 1 (neutral amino acid transporter), member 5"]
["gene2292",26,14,26,19.3494141404444,54,88,121,96.1561024438971,0.201229185133974,-2.3130885343038,0.000351520654599626,0.00795971094950946,"down","yes","INHA","protein_coding","chrNC_037329.1:107501829-107504802:+","gi|124273|sp|P07994.1|INHA_BOVIN",1453,0,"RecName: Full=Inhibin alpha chain; Flags: Precursor","gi|163194|gb|M13273.1|BOVIHNA",1137,0,"Bovine inhibin A subunit mRNA, complete cds","P07994",564,0,"Inhibin alpha chain",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0030509|BMP signaling pathway;GO:0048468|cell development;GO:0042541|hemoglobin biosynthetic process;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0042981|regulation of apoptotic process;GO:0051726|regulation of cell cycle;GO:0042127|regulation of cell proliferation;GO:0043408|regulation of MAPK cascade;GO:0060395|SMAD protein signal transduction;","GO:0005615|extracellular space;GO:0043512|inhibin A complex;GO:0034673|inhibin-betaglycan-ActRII complex;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0005179|hormone activity;GO:0005160|transforming growth factor beta receptor binding;","K05500","INHA; inhibin, alpha"]
["gene22960",2161,3238,4096,2882.32687133278,6690,5051,6903,6845.95858329528,0.421026045697369,-1.24801861020344,{"v":5.28656504652941e-05,"d":"5.29E-05"},0.00170046208954375,"down","yes","FTL","protein_coding","chrNC_037345.1:55538469-55540367:+","gi|982928986|ref|XP_015327242.1|",1035,{"v":9e-136,"d":"9.00E-136"},"PREDICTED: histone RNA hairpin-binding protein isoform X1 [Bos taurus]","gi|73586641|gb|BC103021.1|",882,0,"Bos taurus ferritin, light polypeptide, mRNA (cDNA clone MGC:128093 IMAGE:7954568), complete cds","O46415",358,{"v":1e-123,"d":"1.00E-123"},"Ferritin light chain","TM1128",68.9,{"v":2e-13,"d":"2.00E-13"},"COG1528","pfam00210","Ferritin","Ferritin-like domain. This family contains ferritins and other ferritin-like proteins such as members of the DPS family and bacterioferritins.","GO:0006880|intracellular sequestering of iron ion;GO:0006826|iron ion transport;","GO:0005737|cytoplasm;GO:0008043|intracellular ferritin complex;","GO:0008199|ferric iron binding;GO:0005506|iron ion binding;","K13625","FTL; ferritin light chain"]
["gene23170",149,79,71,86.5281949320915,204,306,210,264.351193083667,0.327322884087401,-1.61121362600513,0.000114145294991566,0.00323404112353959,"down","yes","LOC100335553","protein_coding","chrNC_037345.1:59353249-59366096:-","gi|926729605|ref|XP_013832210.1|",1263,0,"PREDICTED: zinc finger protein 2 homolog [Capra hircus]","gi|965912663|ref|XM_015091444.1|",1453,0,"PREDICTED: Ovis aries musimon zinc finger protein 235-like (LOC106990272), transcript variant X2, partial mRNA","Q96SE7",281,{"v":2e-138,"d":"2.00E-138"},"Zinc finger protein 347",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["gene23171",33,50,42,37.8855593874648,105,110,119,122.570055784187,0.309093107162903,-1.69388661271573,0.000963526361570571,0.0175433124581812,"down","yes","LOC101902926","protein_coding","chrNC_037345.1:59372791-59414231:-","gi|982954498|ref|XP_015313773.1|",4009,0,"PREDICTED: zinc finger protein 665-like [Bos taurus]","gi|983000485|ref|XM_015467685.1|",3993,0,"PREDICTED: Bos taurus zinc finger protein 665-like (LOC101902574), mRNA","Q6ZNA1",789,0,"Zinc finger protein 836",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["gene23621",464,383,705,462.965804721838,1761,516,1344,1332.71875449529,0.347384474901583,-1.52539481545905,0.00101287601480951,0.0182364660595921,"down","yes","SUPT4H1","protein_coding","chrNC_037346.1:9314437-9320712:-","gi|664708282|ref|XP_008511077.1|",655,{"v":6e-79,"d":"6.00E-79"},"PREDICTED: transcription elongation factor SPT4 [Equus przewalskii]","gi|402692681|ref|NM_001034792.2|",1592,0,"Bos taurus SPT4 homolog, DSIF elongation factor subunit (SUPT4H1), mRNA","Q4R941",246,{"v":6e-77,"d":"6.00E-77"},"Transcription elongation factor SPT4","ECU08g1660",106,{"v":8e-26,"d":"8.00E-26"},"COG5204","pfam06093","Spt4","Spt4/RpoE2 zinc finger. This family consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles. RpoE2 is one of 13 subunits in the archaeal RNA polymerase. These proteins contain a C4-type zinc finger, and the structure has been solved in. The structure reveals that Spt4-Spt5 binding is governed by an acid-dipole interaction between Spt5 and Spt4, and the complex binds to and travels along the elongating RNA polymerase. The Spt4-Spt5 complex is likely to be an ancient, core component of the transcription elongation machinery.","GO:0032785|negative regulation of DNA-templated transcription, elongation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0032786|positive regulation of DNA-templated transcription, elongation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0006368|transcription elongation from RNA polymerase II promoter;","GO:0032044|DSIF complex;","GO:0046982|protein heterodimerization activity;GO:0008270|zinc ion binding;","K15171","SUPT4H1, SPT4; transcription elongation factor SPT4"]
["gene23707",329,447,443,368.289731212849,637,800,714,789.414970994941,0.466535022446653,-1.09994270767194,0.000325007208969875,0.00746600698801892,"down","yes","AATF","protein_coding","chrNC_037346.1:13312265-13420345:+","gi|528920676|ref|XP_001252958.5|",2127,0,"PREDICTED: protein AATF isoform X1 [Bos taurus]","gi|983001295|ref|XM_001252957.6|",2092,0,"PREDICTED: Bos taurus apoptosis antagonizing transcription factor (AATF), transcript variant X1, mRNA","Q9NY61",629,0,"Protein AATF",".",".",".",".","pfam13339","AATF-Che1","Apoptosis antagonizing transcription factor. The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.","GO:0007155|cell adhesion;GO:0006974|cellular response to DNA damage stimulus;GO:0040016|embryonic cleavage;GO:0042985|negative regulation of amyloid precursor protein biosynthetic process;GO:0043066|negative regulation of apoptotic process;GO:2000378|negative regulation of reactive oxygen species metabolic process;GO:0032929|negative regulation of superoxide anion generation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0007346|regulation of mitotic cell cycle;GO:0042254|ribosome biogenesis;","GO:0005737|cytoplasm;GO:0005794|Golgi apparatus;GO:0005730|nucleolus;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0043522|leucine zipper domain binding;GO:0003723|RNA binding;GO:0048156|tau protein binding;","K14782","AATF, BFR2; protein AATF/BFR2"]
["gene23744",0,0,1,0.307121633608102,42,11,27,29.4813910348865,0.0104174743058993,-6.58485064805413,{"v":1.88405317906332e-05,"d":"1.88E-05"},0.000723471349284733,"down","yes","GAS2L2","protein_coding","chrNC_037346.1:14621309-14629037:+","gi|329663818|ref|NP_001192571.1|",2804,0,"GAS2-like protein 2 [Bos taurus]","gi|594064531|ref|XM_006056218.1|",2028,0,"PREDICTED: Bubalus bubalis growth arrest-specific 2 like 2 (GAS2L2), mRNA","Q8NHY3",726,0,"GAS2-like protein 2",".",".",".",".","pfam02187","GAS2","Growth-Arrest-Specific Protein 2 Domain.","GO:0001578|microtubule bundle formation;GO:0007026|negative regulation of microtubule depolymerization;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;","GO:0051015|actin filament binding;GO:0008093|cytoskeletal adaptor activity;GO:0008017|microtubule binding;",".","."]
["gene2376",3683,5278,5442,4360.92522221545,9412,7986,8017,9342.58763749947,0.466779161344066,-1.09918793936189,0.0003432611811232,0.00781583678256491,"down","yes","CAB39","protein_coding","chrNC_037329.1:118530388-118632801:+","gi|742105638|ref|XP_010835284.1|",1878,0,"PREDICTED: calcium-binding protein 39 [Bison bison bison]","gi|402692823|ref|NM_001046087.2|",3865,0,"Bos taurus calcium binding protein 39 (CAB39), mRNA","Q9Y376",702,0,"Calcium-binding protein 39",".",".",".",".","pfam08569","Mo25","Mo25-like. Mo25-like proteins are involved in both polarised growth and cytokinesis. In fission yeast Mo25 is localized alternately to the spindle pole body and to the site cell division in a cell cycle dependent manner.","GO:0007050|cell cycle arrest;GO:0071476|cellular hypotonic response;GO:0035556|intracellular signal transduction;GO:1901380|negative regulation of potassium ion transmembrane transport;GO:1901017|negative regulation of potassium ion transmembrane transporter activity;GO:0043312|neutrophil degranulation;GO:0018105|peptidyl-serine phosphorylation;GO:0010800|positive regulation of peptidyl-threonine phosphorylation;GO:0071902|positive regulation of protein serine/threonine kinase activity;GO:0051291|protein heterooligomerization;GO:0023014|signal transduction by protein phosphorylation;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0034774|secretory granule lumen;GO:1902554|serine/threonine protein kinase complex;","GO:0019900|kinase binding;GO:0030295|protein kinase activator activity;GO:0043539|protein serine/threonine kinase activator activity;GO:0004674|protein serine/threonine kinase activity;","K08272","CAB39, MO25; calcium binding protein 39"]
["gene23764",314,318,340,290.471273781021,1620,615,1211,1268.3398289449,0.229016914199293,-2.12647394141097,{"v":2.64692544905156e-06,"d":"2.65E-06"},0.000137331066997847,"down","yes","RFFL","protein_coding","chrNC_037346.1:14997728-15075166:+","gi|942066089|ref|XP_014334884.1|",2012,0,"PREDICTED: E3 ubiquitin-protein ligase rififylin [Bos mutus]","gi|983001330|ref|XM_005192867.3|",3692,0,"PREDICTED: Bos taurus ring finger and FYVE-like domain containing E3 ubiquitin protein ligase (RFFL), transcript variant X2, mRNA","Q8WZ73",629,0,"E3 ubiquitin-protein ligase rififylin",".",".",".",".","pfam13920","zf-C3HC4_3","Zinc finger, C3HC4 type (RING finger).","GO:0006915|apoptotic process;GO:2001271|negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis;GO:1902042|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors;GO:1901797|negative regulation of signal transduction by p53 class mediator;GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936|protein K48-linked ubiquitination;GO:0010762|regulation of fibroblast migration;GO:0032006|regulation of TOR signaling;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0010008|endosome membrane;GO:0016020|membrane;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;GO:0055038|recycling endosome membrane;","GO:0046872|metal ion binding;GO:0002039|p53 binding;GO:0002020|protease binding;GO:0019901|protein kinase binding;GO:0061630|ubiquitin protein ligase activity;GO:0031625|ubiquitin protein ligase binding;",".","."]
["gene23913",14,170,272,142.897815122231,2390,1434,2192,2210.81848096224,0.0646357067994275,-3.95152481447076,{"v":3.63307574162436e-08,"d":"3.63E-08"},{"v":3.43229417166506e-06,"d":"3.43E-06"},"down","yes","TRARG1","protein_coding","chrNC_037346.1:21603442-21620155:-","gi|139947491|ref|NP_001077176.1|",643,{"v":4e-74,"d":"4.00E-74"},"tumor suppressor candidate 5 [Bos taurus]","gi|139947490|ref|NM_001083707.1|",3479,0,"Bos taurus tumor suppressor candidate 5 (TUSC5), mRNA","Q2MHH0",156,{"v":2e-41,"d":"2.00E-41"},"Tumor suppressor candidate 5 homolog",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.","GO:0009607|response to biotic stimulus;","GO:0016021|integral component of membrane;GO:0016020|membrane;",".",".","."]
["gene24225",1982,638,1382,1150.08123238957,10887,3140,8211,8185.50255155926,0.140502214145726,-2.83133522912521,{"v":4.15881858095249e-07,"d":"4.16E-07"},{"v":2.85916272128085e-05,"d":"2.86E-05"},"down","yes","MYH10","protein_coding","chrNC_037346.1:28061491-28183071:-","gi|803119997|ref|XP_012041093.1|",8667,0,"PREDICTED: myosin-10 isoform X1 [Ovis aries]","gi|982956933|ref|XM_015458670.1|",7467,0,"PREDICTED: Bos taurus myosin, heavy chain 10, non-muscle (MYH10), transcript variant X3, mRNA","Q27991",3232,0,"Myosin-10","SPCC645.05c",779,0,"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0030048|actin filament-based movement;GO:0007512|adult heart development;GO:0035904|aorta development;GO:0007411|axon guidance;GO:0055003|cardiac myofibril assembly;GO:0003279|cardiac septum development;GO:0007155|cell adhesion;GO:0008283|cell proliferation;GO:0021680|cerebellar Purkinje cell layer development;GO:0060976|coronary vasculature development;GO:0006887|exocytosis;GO:0021592|fourth ventricle development;GO:0001701|in utero embryonic development;GO:0021670|lateral ventricle development;GO:0007018|microtubule-based movement;GO:0000281|mitotic cytokinesis;GO:0050885|neuromuscular process controlling balance;GO:0001764|neuron migration;GO:0007097|nuclear migration;GO:0001778|plasma membrane repair;GO:0050714|positive regulation of protein secretion;GO:0008360|regulation of cell shape;GO:0060041|retina development in camera-type eye;GO:0006930|substrate-dependent cell migration, cell extension;GO:0021678|third ventricle development;GO:0055015|ventricular cardiac muscle cell development;","GO:0005903|brush border;GO:0005938|cell cortex;GO:0032154|cleavage furrow;GO:0005829|cytosol;GO:0043197|dendritic spine;GO:0030426|growth cone;GO:0030027|lamellipodium;GO:0030496|midbody;GO:0016460|myosin II complex;GO:0097513|myosin II filament;GO:0031594|neuromuscular junction;GO:0043025|neuronal cell body;GO:0005844|polysome;GO:0005819|spindle;GO:0001725|stress fiber;","GO:0051015|actin filament binding;GO:0030898|actin-dependent ATPase activity;GO:0043531|ADP binding;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0000146|microfilament motor activity;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0048027|mRNA 5'-UTR binding;GO:0035613|RNA stem-loop binding;","K10352","MYH; myosin heavy chain"]
["gene24386",372,118,198,196.432613703853,1155,327,863,863.226681958237,0.227556235006828,-2.1357049784112,0.000352192695232391,0.00796860411393763,"down","yes","ABCC3","protein_coding","chrNC_037346.1:36047549-36095574:-","gi|440910481|gb|ELR60275.1|",7830,0,"Canalicular multispecific organic anion transporter 2, partial [Bos mutus]","gi|300795330|ref|NM_001192756.1|",5096,0,"Bos taurus ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (ABCC3), mRNA","O15438",2558,0,"Canalicular multispecific organic anion transporter 2","YDR135c",994,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0015721|bile acid and bile salt transport;GO:0015722|canalicular bile acid transport;GO:0006855|drug transmembrane transport;GO:0055085|transmembrane transport;GO:0042908|xenobiotic transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0043225|anion transmembrane-transporting ATPase activity;GO:0015432|bile acid-exporting ATPase activity;GO:0008514|organic anion transmembrane transporter activity;GO:0008559|xenobiotic-transporting ATPase activity;","K05667","ABCC3; ATP-binding cassette, subfamily C (CFTR/MRP), member 3"]
["gene24393",655,532,626,537.312168104297,1420,1162,1367,1450.64018174385,0.37039658411942,-1.4328573010859,{"v":2.01289623278967e-06,"d":"2.01E-06"},0.000110654995024512,"down","yes","ACSF2","protein_coding","chrNC_037346.1:36241654-36273156:-","gi|118151292|ref|NP_001071580.1|",3213,0,"acyl-CoA synthetase family member 2, mitochondrial precursor [Bos taurus]","gi|118151291|ref|NM_001078112.1|",2011,0,"Bos taurus acyl-CoA synthetase family member 2 (ACSF2), mRNA","Q17QJ1",1221,0,"Acyl-CoA synthetase family member 2, mitochondrial","RSc0442",541,0,"COG0318","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0006631|fatty acid metabolic process;","GO:0005739|mitochondrion;","GO:0005524|ATP binding;GO:0016874|ligase activity;","K00666","K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]"]
["gene24452",85,15,28,35.6681460602037,193,239,192,229.154064977182,0.155651378315088,-2.68360974275397,{"v":5.39940892098865e-06,"d":"5.40E-06"},0.000252128536701681,"down","yes","HOXB6","protein_coding","chrNC_037346.1:37889310-37896710:+","gi|640798220|ref|XP_008055280.1|",990,{"v":8e-118,"d":"8.00E-118"},"PREDICTED: homeobox protein Hox-B6 isoform X1 [Tarsius syrichta]","gi|983001953|ref|XM_015468102.1|",6334,0,"PREDICTED: Bos taurus homeobox B6 (HOXB6), mRNA","P17509",330,{"v":7e-101,"d":"7.00E-101"},"Homeobox protein Hox-B6",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009952|anterior/posterior pattern specification;GO:0048704|embryonic skeletal system morphogenesis;GO:0034101|erythrocyte homeostasis;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003723|RNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;","K09306","HOX_6; homeobox protein HoxA/B/C6"]
["gene24470",375,342,431,342.182584187326,779,547,692,741.700781300894,0.461348555663053,-1.11607095481887,0.000361156366430664,0.00814557493330694,"down","yes","COPZ2","protein_coding","chrNC_037346.1:38443733-38453502:+","gi|803334876|ref|XP_012025541.1|",946,{"v":5e-121,"d":"5.00E-121"},"PREDICTED: coatomer subunit zeta-2 isoform X3 [Ovis aries musimon]","gi|803334875|ref|XM_012170151.1|",914,0,"PREDICTED: Ovis aries musimon coatomer protein complex subunit zeta 2 (COPZ2), transcript variant X3, mRNA","Q9P299",322,{"v":2e-104,"d":"2.00E-104"},"Coatomer subunit zeta-2","YPL010w",107,{"v":1e-25,"d":"1.00E-25"},"COG5541","pfam01217","Clat_adaptor_s","Clathrin adaptor complex small chain.","GO:0006888|ER to Golgi vesicle-mediated transport;GO:0006886|intracellular protein transport;GO:0006890|retrograde vesicle-mediated transport, Golgi to ER;","GO:0005801|cis-Golgi network;GO:0030126|COPI vesicle coat;GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;GO:0033116|endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0000139|Golgi membrane;GO:0030133|transport vesicle;",".",".","."]
["gene24497",13,16,18,14.159774351122,38,62,57,57.5318713462059,0.246120524498736,-2.0225631227562,0.00369739395273776,0.0481704868127699,"down","yes","SRCIN1","protein_coding","chrNC_037346.1:39146533-39218472:-","gi|982957717|ref|XP_015314298.1|",5335,0,"PREDICTED: SRC kinase signaling inhibitor 1 isoform X14 [Bos taurus]","gi|926717468|ref|XM_013972418.1|",6227,0,"PREDICTED: Capra hircus SRC kinase signaling inhibitor 1 (SRCIN1), mRNA","Q9C0H9",1857,0,"SRC kinase signaling inhibitor 1",".",".",".",".","pfam05403","Plasmodium_HRP","Plasmodium histidine-rich protein (HRPII/III). This family consists of several histidine-rich protein II and III sequence from Plasmodium falciparum.","GO:0006887|exocytosis;GO:0050709|negative regulation of protein secretion;GO:0061099|negative regulation of protein tyrosine kinase activity;GO:0061098|positive regulation of protein tyrosine kinase activity;GO:0030334|regulation of cell migration;GO:0061001|regulation of dendritic spine morphogenesis;GO:0034446|substrate adhesion-dependent cell spreading;","GO:0015629|actin cytoskeleton;GO:0030424|axon;GO:0030054|cell junction;GO:0005737|cytoplasm;GO:0030425|dendrite;GO:0030175|filopodium;GO:0030027|lamellipodium;GO:0043025|neuronal cell body;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;GO:0045202|synapse;","GO:0019904|protein domain specific binding;GO:0019901|protein kinase binding;",".","."]
["gene2451",24,8,5,10.4123072857623,106,30,89,82.7556317016196,0.125819923933448,-2.99056769982434,0.000496686678128164,0.0105047943763341,"down","yes","TSSK3","protein_coding","chrNC_037329.1:121199292-121202058:-","gi|594061239|ref|XP_006054703.1|",1375,0,"PREDICTED: testis-specific serine/threonine-protein kinase 3 isoform X2 [Bubalus bubalis]","gi|926686178|ref|XM_013973564.1|",1254,0,"PREDICTED: Capra hircus testis-specific serine kinase 3 (TSSK3), mRNA","Q9D2E1",456,{"v":5e-157,"d":"5.00E-157"},"Testis-specific serine/threonine-protein kinase 3",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0007275|multicellular organismal development;GO:0006468|protein phosphorylation;GO:0048240|sperm capacitation;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;","K08811","TSSK, STK22; testis-specific serine kinase [EC:2.7.11.1]"]
["gene24535",140,118,127,114.162386771676,332,213,337,323.907221544876,0.352453971934241,-1.50449323112913,0.000184302657808502,0.00472872223914961,"down","yes","PPP1R1B","protein_coding","chrNC_037346.1:40006493-40015037:+","gi|27807175|ref|NP_777072.1|",762,{"v":2e-94,"d":"2.00E-94"},"protein phosphatase 1 regulatory subunit 1B [Bos taurus]","gi|31341450|ref|NM_174647.2|",1655,0,"Bos taurus protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B), mRNA","P07516",298,{"v":6e-96,"d":"6.00E-96"},"Protein phosphatase 1 regulatory subunit 1B",".",".",".",".","pfam05395","DARPP-32","Protein phosphatase inhibitor 1/DARPP-32. This family consists of several mammalian protein phosphatase inhibitor 1 (IPP-1) and dopamine- and cAMP-regulated neuronal phosphoprotein (DARPP-32) proteins. Protein phosphatase inhibitor-1 is involved in signal transduction and is an endogenous inhibitor of protein phosphatase-1. It has been demonstrated that DARPP-32, if phosphorylated, can inhibit protein-phosphatase-1. DARPP-32 has a key role in many neurotransmitter pathways throughout the brain and has been shown to be involved in controlling receptors, ion channels and other physiological factors including the brain's response to drugs of abuse, such as cocaine, opiates and nicotine. DARPP-32 is reciprocally regulated by the two neurotransmitters that are most often implicated in schizophrenia - dopamine and glutamate. Dopamine activates DARPP-32 through the D1 receptor pathway and disables DARPP-32 through the D2 receptor. Glutamate, acting through the N-methyl-d-aspartate receptor, renders DARPP-32 inactive. A mutant form of DARPP-32 has been linked with gastric cancers.","GO:0048148|behavioral response to cocaine;GO:0043987|histone H3-S10 phosphorylation;GO:0035556|intracellular signal transduction;GO:0007626|locomotory behavior;GO:0007621|negative regulation of female receptivity;GO:0006469|negative regulation of protein kinase activity;GO:0001975|response to amphetamine;GO:0043278|response to morphine;GO:0006351|transcription, DNA-templated;GO:0008542|visual learning;","GO:1904115|axon cytoplasm;GO:0005829|cytosol;GO:0032839|dendrite cytoplasm;GO:0043025|neuronal cell body;GO:0005634|nucleus;","GO:0004865|protein serine/threonine phosphatase inhibitor activity;","K15494","PPP1R1B, DARPP32; protein phosphatase 1 regulatory subunit 1B"]
["gene24547",29,27,29,25.3129785814631,106,197,140,162.452173033972,0.155818036217771,-2.68206585727788,{"v":2.11817133610695e-06,"d":"2.12E-06"},0.000115551713939708,"down","yes","GSDMB","protein_coding","chrNC_037346.1:40242818-40256060:-","gi|982957805|ref|XP_015314318.1|",1899,0,"PREDICTED: gasdermin-B isoform X2 [Bos taurus]","gi|982957804|ref|XM_015458832.1|",3365,0,"PREDICTED: Bos taurus gasdermin B (GSDMB), transcript variant X3, mRNA","Q8TAX9",330,{"v":2e-100,"d":"2.00E-100"},"Gasdermin-B",".",".",".",".","pfam04598","Gasdermin","Gasdermin family. The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein","GO:0012501|programmed cell death;","GO:0005829|cytosol;GO:0005886|plasma membrane;",".",".","."]
["gene24634",5,3,0,2.28626922180083,21,21,21,23.136299500179,0.0988174112192462,-3.33909092866726,0.00387516539838714,0.0497132841642911,"down","yes","KRT19","protein_coding","chrNC_037346.1:41731623-41735456:-","gi|62751472|ref|NP_001015600.1|",1672,0,"keratin, type I cytoskeletal 19 [Bos taurus]","gi|325910834|ref|NM_001015600.3|",1386,0,"Bos taurus keratin 19, type I (KRT19), mRNA","P08728",648,0,"Keratin, type I cytoskeletal 19",".",".",".",".","pfam00038","Filament","Intermediate filament protein.","GO:0060706|cell differentiation involved in embryonic placenta development;GO:0007219|Notch signaling pathway;GO:0043627|response to estrogen;GO:0045214|sarcomere organization;","GO:0016327|apicolateral plasma membrane;GO:0043034|costamere;GO:0005882|intermediate filament;GO:0042383|sarcolemma;GO:1990357|terminal web;GO:0030018|Z disc;","GO:0008307|structural constituent of muscle;","K07604","KRT1; type I keratin, acidic"]
["gene24705",0,0,0,0,0,31,7,13.9034248578455,{"$error":"#NAME?"},{"$error":"#NAME?"},0.00137152294933846,0.0232230986751191,"down","yes","G6PC","protein_coding","chrNC_037346.1:42949589-42962432:+","gi|528996124|ref|XP_005220797.1|",1457,0,"PREDICTED: glucose-6-phosphatase isoform X1 [Bos taurus]","gi|982957859|ref|XM_005220740.3|",3894,0,"PREDICTED: Bos taurus glucose-6-phosphatase, catalytic subunit (G6PC), transcript variant X1, mRNA","Q29RU6",541,{"v":2e-177,"d":"2.00E-177"},"Glucose-6-phosphatase",".",".",".",".","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.","GO:0042632|cholesterol homeostasis;GO:0006094|gluconeogenesis;GO:0051156|glucose 6-phosphate metabolic process;GO:0042593|glucose homeostasis;GO:0015760|glucose-6-phosphate transport;GO:0005980|glycogen catabolic process;GO:0035264|multicellular organism growth;GO:0010468|regulation of gene expression;GO:0008202|steroid metabolic process;GO:0006641|triglyceride metabolic process;GO:0046415|urate metabolic process;","GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0004346|glucose-6-phosphatase activity;GO:0042301|phosphate ion binding;GO:0016773|phosphotransferase activity, alcohol group as acceptor;","K01084","G6PC; glucose-6-phosphatase [EC:3.1.3.9]"]
["gene24719",0,0,0,0,10,12,7,10.6683419488949,{"$error":"#NAME?"},{"$error":"#NAME?"},0.00241459392481107,0.0352562841703094,"down","yes","LOC112442858","snRNA","chrNC_037346.1:43195585-43195775:+","gi|24940209|emb|CAA24954.2|",156,{"v":9e-12,"d":"9.00E-12"},"unnamed protein product [Xenopus laevis]","gi|965960632|ref|XR_001435329.1|",128,{"v":3e-59,"d":"3.00E-59"},"PREDICTED: Ovis aries uncharacterized LOC106991431 (LOC106991431), ncRNA",".",".",".",".",".",".",".",".","pfam01526","DDE_Tnp_Tn3","Tn3 transposase DDE domain. This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli. The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases.",".",".",".",".","."]
["gene2491",4099,3298,8687,4817.07318496855,12616,7818,12021,11923.8221322284,0.403987339927579,-1.30761801208326,0.00293581432824664,0.0407005435370287,"down","yes","FABP3","protein_coding","chrNC_037329.1:122287099-122294639:+","gi|27805809|ref|NP_776738.1|",690,{"v":2e-89,"d":"2.00E-89"},"fatty acid-binding protein, heart [Bos taurus]","gi|74354538|gb|BC102153.1|",684,0,"Bos taurus fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor), mRNA (cDNA clone MGC:127201 IMAGE:7945795), complete cds","P10790",270,{"v":8e-91,"d":"8.00E-91"},"Fatty acid-binding protein, heart",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0042632|cholesterol homeostasis;GO:0044539|long-chain fatty acid import;GO:0055091|phospholipid homeostasis;GO:0046320|regulation of fatty acid oxidation;GO:2001245|regulation of phosphatidylcholine biosynthetic process;","GO:0005615|extracellular space;GO:0005759|mitochondrial matrix;","GO:0008092|cytoskeletal protein binding;GO:0070538|oleic acid binding;","K08752","FABP3; fatty acid-binding protein 3, muscle and heart"]
["gene24916",27,16,42,25.1794188734235,488,128,354,357.15763935332,0.0704994548598038,-3.82624408792426,{"v":8.53811985522811e-10,"d":"8.54E-10"},{"v":1.15450757151428e-07,"d":"1.15E-07"},"down","yes","RAB40B","protein_coding","chrNC_037346.1:49959014-49984081:+","gi|594058531|ref|XP_006053429.1|",1694,0,"PREDICTED: ras-related protein Rab-40B isoform X1 [Bubalus bubalis]","gi|402746466|ref|NM_001102166.2|",1733,0,"Bos taurus RAB40B, member RAS oncogene family (RAB40B), mRNA","Q12829",517,{"v":2e-180,"d":"2.00E-180"},"Ras-related protein Rab-40B",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0035556|intracellular signal transduction;GO:0072659|protein localization to plasma membrane;GO:0016567|protein ubiquitination;","GO:0005768|endosome;GO:0005635|nuclear envelope;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;GO:0008021|synaptic vesicle;","GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07928","RAB40; Ras-related protein Rab-40"]
["gene25201",249,388,302,284.800378854021,719,501,661,691.203108174236,0.412035732313619,-1.27915863952665,{"v":6.21224785141603e-05,"d":"6.21E-05"},0.00196280889754984,"down","yes","SDK2","protein_coding","chrNC_037346.1:57666046-58018215:+","gi|803209587|ref|XP_011965263.1|",10946,0,"PREDICTED: protein sidekick-2 isoform X3 [Ovis aries musimon]","gi|965788397|ref|XM_012109873.2|",6576,0,"PREDICTED: Ovis aries musimon sidekick cell adhesion molecule 2 (SDK2), transcript variant X3, mRNA","Q6V4S5",4040,0,"Protein sidekick-2",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0060219|camera-type eye photoreceptor cell differentiation;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0010842|retina layer formation;GO:0007416|synapse assembly;","GO:0030054|cell junction;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0045202|synapse;",".","K16353","SDK; protein sidekick"]
["gene25236",339,264,190,233.221854983555,598,588,634,668.158819775709,0.349051524997969,-1.51848808030819,{"v":5.78999392592692e-06,"d":"5.79E-06"},0.000266872886430728,"down","yes","ABCA10","protein_coding","chrNC_037346.1:61355077-61409776:+","gi|440903140|gb|ELR53838.1|",7521,0,"ATP-binding cassette sub-family A member 10 [Bos mutus]","gi|983002813|ref|XM_001789465.6|",4554,0,"PREDICTED: Bos taurus ATP binding cassette subfamily A member 10 (ABCA10), transcript variant X1, mRNA","Q8WWZ4",1898,0,"ATP-binding cassette sub-family A member 10",".",".",".",".","pfam00005","ABC_tran","ABC transporter. ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains.","GO:0006869|lipid transport;","GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;","K05652","ABCA10; ATP-binding cassette, subfamily A (ABC1), member 10"]
["gene25300",321,67,108,138.786279960941,298,350,335,360.754457653237,0.384711199034842,-1.3781522674445,0.0013157510588999,0.0224984557049181,"down","yes","DOCK2","protein_coding","chrNC_037347.1:1544533-2002178:+","gi|594105257|ref|XP_006075586.1|",9633,0,"PREDICTED: dedicator of cytokinesis protein 2 [Bubalus bubalis]","gi|983002884|ref|XM_015468318.1|",5965,0,"PREDICTED: Bos taurus dedicator of cytokinesis 2 (DOCK2), transcript variant X2, mRNA","Q92608",3602,0,"Dedicator of cytokinesis protein 2",".",".",".",".","pfam14429","DOCK-C2","C2 domain in Dock180 and Zizimin proteins. The Dock180/Dock1 and Zizimin proteins are atypical GTP/GDP exchange factors for the small GTPases Rac and Cdc42 and are implicated cell-migration and phagocytosis. Across all Dock180 proteins, two regions are conserved: C-terminus termed CZH2 or DHR2 (or the Dedicator of cytokinesis) whereas CZH1/DHR1 contain a new family of the C2 domain.","GO:0030036|actin cytoskeleton organization;GO:0046633|alpha-beta T cell proliferation;GO:0006935|chemotaxis;GO:0001768|establishment of T cell polarity;GO:0001771|immunological synapse formation;GO:0044351|macropinocytosis;GO:0001766|membrane raft polarization;GO:0002277|myeloid dendritic cell activation involved in immune response;GO:0045060|negative thymic T cell selection;GO:0043312|neutrophil degranulation;GO:0050766|positive regulation of phagocytosis;GO:0045059|positive thymic T cell selection;GO:0050690|regulation of defense response to virus by virus;GO:0007264|small GTPase mediated signal transduction;","GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0016020|membrane;GO:0035580|specific granule lumen;","GO:0005096|GTPase activator activity;GO:0030676|Rac guanyl-nucleotide exchange factor activity;GO:0042608|T cell receptor binding;","K12367","DOCK2; dedicator of cytokinesis protein 2"]
["gene25335",0,0,0,0,18,3,19,14.6872732109078,{"$error":"#NAME?"},{"$error":"#NAME?"},0.000451633845088458,0.00977660488180485,"down","yes","TRNAG-CCC","tRNA","chrNC_037347.1:4627321-4627393:-",".",".",".",".","gi|4666291|dbj|AB010597.1|",64,{"v":3e-24,"d":"3.00E-24"},"Physeter catodon SINE DNA, clone: PM(1-III)8",".",".",".",".",".",".",".",".","pfam06003","SMN","Survival motor neuron protein (SMN). This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs.",".",".",".",".","."]
["gene25450",109,34,63,58.8989968254816,250,186,264,256.998552929913,0.229180266402294,-2.12544526889551,{"v":2.11030329753516e-06,"d":"2.11E-06"},0.000115343033298804,"down","yes","ADAMTS6","protein_coding","chrNC_037347.1:14047155-14333329:+","gi|965980387|ref|XP_014956762.1|",4889,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X5 [Ovis aries]","gi|965980386|ref|XM_015101276.1|",4134,0,"PREDICTED: Ovis aries ADAM metallopeptidase with thrombospondin type 1 motif 6 (ADAMTS6), transcript variant X11, mRNA","Q9UKP5",1773,0,"A disintegrin and metalloproteinase with thrombospondin motifs 6",".",".",".",".","pfam05986","ADAM_spacer1","ADAM-TS Spacer 1. This family represents the Spacer-1 region from the ADAM-TS family of metalloproteinases.","GO:0035904|aorta development;GO:0003279|cardiac septum development;GO:0060976|coronary vasculature development;","GO:0005576|extracellular region;","GO:0046872|metal ion binding;GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;","K08621","ADAMTS6; a disintegrin and metalloproteinase with thrombospondin motifs 6 [EC:3.4.24.-]"]
["gene25459",59,5,40,29.3002247136935,298,66,186,202.745027680702,0.144517599513403,-2.79068289846182,0.00307018892572827,0.0420525973307505,"down","yes","RGS7BP","protein_coding","chrNC_037347.1:14840630-14973460:-","gi|116004079|ref|NP_001070398.1|",1294,{"v":2e-171,"d":"2.00E-171"},"regulator of G-protein signaling 7-binding protein [Bos taurus]","gi|116004078|ref|NM_001076930.1|",2173,0,"Bos taurus regulator of G-protein signaling 7 binding protein (RGS7BP), mRNA","Q08DH5",503,{"v":6e-173,"d":"6.00E-173"},"Regulator of G-protein signaling 7-binding protein",".",".",".",".","pfam14523","Syntaxin_2","Syntaxin-like protein. This domain includes syntaxin-like domains including from the Vam3p protein.","GO:0007186|G-protein coupled receptor signaling pathway;GO:0009968|negative regulation of signal transduction;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;",".",".","."]
["gene25616",0,0,0,0,1,18,14,12.0331647703403,{"$error":"#NAME?"},{"$error":"#NAME?"},0.00162994165430652,0.0264979289681022,"down","yes","C9","protein_coding","chrNC_037347.1:35077223-35144037:+","gi|78369352|ref|NP_001030441.1|",2834,0,"complement component C9 precursor [Bos taurus]","gi|402691864|ref|NM_001035364.2|",2679,0,"Bos taurus complement component 9 (C9), mRNA","Q3MHN2",1096,0,"Complement component C9",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.","GO:0001906|cell killing;GO:0006957|complement activation, alternative pathway;GO:0006958|complement activation, classical pathway;GO:0019835|cytolysis;GO:0051260|protein homooligomerization;","GO:0005829|cytosol;GO:0005615|extracellular space;GO:0005579|membrane attack complex;GO:0044218|other organism cell membrane;GO:0005886|plasma membrane;",".","K04000","C9; complement component 9"]
["gene25660",670,826,922,728.478517891576,2460,1270,1881,2064.53371765196,0.352853775970339,-1.50285764619845,0.000164804230271264,0.00439442008772843,"down","yes","AMACR","protein_coding","chrNC_037347.1:39765311-39781007:+","gi|119913313|ref|XP_593629.3|",2031,0,"PREDICTED: alpha-methylacyl-CoA racemase [Bos taurus]","gi|983003206|ref|XM_593629.7|",1592,0,"PREDICTED: Bos taurus alpha-methylacyl-CoA racemase (AMACR), mRNA","Q9UHK6",677,0,"Alpha-methylacyl-CoA racemase","Rv1143",340,{"v":3e-111,"d":"3.00E-111"},"COG1804","pfam02515","CoA_transf_3","CoA-transferase family III. CoA-transferases are found in organisms from all lines of descent. Most of these enzymes belong to two well-known enzyme families, but recent work on unusual biochemical pathways of anaerobic bacteria has revealed the existence of a third family of CoA-transferases. The members of this enzyme family differ in sequence and reaction mechanism from CoA-transferases of the other families. Currently known enzymes of the new family are a formyl-CoA: oxalate CoA-transferase, a succinyl-CoA: (R)-benzylsuccinate CoA-transferase, an (E)-cinnamoyl-CoA: (R)-phenyllactate CoA-transferase, and a butyrobetainyl-CoA: (R)-carnitine CoA-transferase. In addition, a large number of proteins of unknown or differently annotated function from Bacteria, Archaea and Eukarya apparently belong to this enzyme family. Properties and reaction mechanisms of the CoA-transferases of family III are described and compared to those of the previously known CoA-transferases.","GO:0006699|bile acid biosynthetic process;GO:0008206|bile acid metabolic process;GO:0033540|fatty acid beta-oxidation using acyl-CoA oxidase;GO:0006625|protein targeting to peroxisome;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;GO:0005739|mitochondrion;GO:0005782|peroxisomal matrix;GO:0005777|peroxisome;GO:0005886|plasma membrane;","GO:0008111|alpha-methylacyl-CoA racemase activity;GO:0005102|receptor binding;","K01796","E5.1.99.4, AMACR, mcr; alpha-methylacyl-CoA racemase [EC:5.1.99.4]"]
["gene25667",2104,1789,418,1263.01506125217,5391,2648,4119,4473.61418440966,0.282325432902488,-1.82456899702581,0.00257157045246954,0.0368991070060504,"down","yes","NPR3","protein_coding","chrNC_037347.1:40915159-40995919:-","gi|391624|dbj|BAA02726.1|",2659,0,"type C atrial natriuretic peptide receptor [Bos taurus]","gi|594063672|ref|XM_006055803.1|",4106,0,"PREDICTED: Bubalus bubalis natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) (NPR3), transcript variant X2, mRNA","P10730",1022,0,"Atrial natriuretic peptide receptor 3",".",".",".",".","pfam01094","ANF_receptor","Receptor family ligand binding region. This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.","GO:0002158|osteoclast proliferation;GO:0035810|positive regulation of urine volume;GO:0008217|regulation of blood pressure;GO:0033688|regulation of osteoblast proliferation;GO:0001501|skeletal system development;","GO:0016021|integral component of membrane;","GO:0016941|natriuretic peptide receptor activity;","K12325","NPR3; atrial natriuretic peptide clearance receptor"]
["gene25796",392,384,834,484.147340084283,2428,954,1961,1965.48289804164,0.246324880550563,-2.02136573731429,0.00080012442473852,0.0152902544957902,"down","yes","UBE2QL1","protein_coding","chrNC_037347.1:66694144-66751532:-","gi|545878515|ref|XP_003134207.3|",958,{"v":9e-119,"d":"9.00E-119"},"PREDICTED: ubiquitin-conjugating enzyme E2Q-like protein 1 [Sus scrofa]","gi|983003279|ref|XR_001498867.1|",1903,0,"PREDICTED: Bos taurus translation initiation factor IF-2-like (LOC104970183), misc_RNA","A1L167",336,{"v":2e-109,"d":"2.00E-109"},"Ubiquitin-conjugating enzyme E2Q-like protein 1",".",".",".",".","pfam00179","UQ_con","Ubiquitin-conjugating enzyme. Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine.",".","GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0061631|ubiquitin conjugating enzyme activity;","K10582","UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]"]
["gene25831",47,37,43,37.5810765070942,72,139,108,116.907646535794,0.321459524853131,-1.63729099643111,0.00215681170873094,0.0325415097101017,"down","yes","LOC104975299","protein_coding","chrNC_037347.1:71444281-71483796:-","gi|742191020|ref|XP_010855430.1|",349,{"v":3e-31,"d":"3.00E-31"},"PREDICTED: tubulin polymerization-promoting protein [Bison bison bison]","gi|983003334|ref|XR_001498884.1|",2787,0,"PREDICTED: Bos taurus uncharacterized LOC104975299 (LOC104975299), transcript variant X4, misc_RNA",".",".",".",".",".",".",".",".","pfam15449","Retinal","Retinal protein. This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.",".",".",".",".","."]
["gene25888",39,37,40,34.5747257115802,224,160,152,197.309942284618,0.17523052975053,-2.51267394276471,{"v":5.15733374810448e-07,"d":"5.16E-07"},{"v":3.46220915687457e-05,"d":"3.46E-05"},"down","yes","LOC100849023","snoRNA","chrNC_037348.1:1964407-1964480:+",".",".",".",".","gi|983003407|ref|XR_001498908.1|",73,{"v":3e-29,"d":"3.00E-29"},"PREDICTED: Bos taurus uncharacterized LOC100849023 (LOC100849023), ncRNA",".",".",".",".",".",".",".",".","pfam11898","DUF3418","Domain of unknown function (DUF3418). This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is typically between 582 to 594 amino acids in length. This domain is found associated with pfam07717, pfam00271, pfam04408.",".",".",".",".","."]
["gene26",530,356,2242,943.364511870103,1963,1728,2026,2099.19235225295,0.449394030450635,-1.15394713435811,0.000864898643976545,0.0161706574123819,"down","yes","MRPS6","protein_coding","chrNC_037328.1:1390798-1455166:-","gi|594671699|ref|XP_007183787.1|",680,{"v":2e-85,"d":"2.00E-85"},"PREDICTED: 28S ribosomal protein S6, mitochondrial [Balaenoptera acutorostrata scammoni]","gi|942048194|ref|XM_014477449.1|",708,0,"PREDICTED: Bos mutus mitochondrial ribosomal protein S6 (MRPS6), mRNA","P82931",225,{"v":1e-71,"d":"1.00E-71"},"28S ribosomal protein S6, mitochondrial",".",".",".",".","pfam01250","Ribosomal_S6","Ribosomal protein S6.","GO:0032543|mitochondrial translation;","GO:0005743|mitochondrial inner membrane;GO:0005763|mitochondrial small ribosomal subunit;","GO:0070181|small ribosomal subunit rRNA binding;GO:0003735|structural constituent of ribosome;","K02990","RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6"]
["gene26081",75,331,343,233.364014907677,3216,3216,3342,3588.64159311537,0.065028509772437,-3.94278382717676,{"v":2.17750670485449e-15,"d":"2.18E-15"},{"v":8.28352583949379e-13,"d":"8.28E-13"},"down","yes","PLIN1","protein_coding","chrNC_037348.1:21078033-21091966:-","gi|139948286|ref|NP_001077168.1|",2078,0,"perilipin-1 [Bos taurus]","gi|982960048|ref|XM_010816962.2|",3207,0,"PREDICTED: Bos taurus perilipin 1 (PLIN1), transcript variant X2, mRNA","O60240",684,0,"Perilipin-1",".",".",".",".","pfam03036","Perilipin","Perilipin family. The perilipin family includes lipid droplet-associated protein (perilipin) and adipose differentiation-related protein (adipophilin).","GO:0016042|lipid catabolic process;GO:0006629|lipid metabolic process;","GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005811|lipid particle;","GO:0008289|lipid binding;","K08768","PLIN; perilipin"]
["gene26087",84,111,79,82.5316233412135,301,354,305,352.514525546152,0.23412261725484,-2.09466378314031,{"v":2.47944506554484e-07,"d":"2.48E-07"},{"v":1.81997715278387e-05,"d":"1.82E-05"},"down","yes","ANPEP","protein_coding","chrNC_037348.1:21195686-21225013:-","gi|296475533|tpg|DAA17648.1|",4795,0,"TPA: aminopeptidase N [Bos taurus]","gi|742124286|ref|XM_010841037.1|",3677,0,"PREDICTED: Bison bison bison alanyl (membrane) aminopeptidase (ANPEP), mRNA","P79098",1844,0,"Aminopeptidase N","YHR047c",384,{"v":8e-115,"d":"8.00E-115"},"COG0308","pfam01433","Peptidase_M1","Peptidase family M1. Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase, this enzyme also has an aminopeptidase activity.","GO:0001525|angiogenesis;GO:0030154|cell differentiation;GO:0007267|cell-cell signaling;GO:0043171|peptide catabolic process;GO:0006508|proteolysis;GO:0008217|regulation of blood pressure;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0070006|metalloaminopeptidase activity;GO:0042277|peptide binding;GO:0001618|virus receptor activity;GO:0008270|zinc ion binding;","K11140","ANPEP; aminopeptidase N [EC:3.4.11.2]"]
["gene2609",171,132,118,124.065659920018,1126,450,909,914.131631197426,0.135719688156402,-2.88129807460742,{"v":2.46274168543519e-09,"d":"2.46E-09"},{"v":2.94590217966255e-07,"d":"2.95E-07"},"down","yes","PAFAH2","protein_coding","chrNC_037329.1:127089906-127125126:+","gi|27807031|ref|NP_776995.1|",2119,0,"platelet-activating factor acetylhydrolase 2, cytoplasmic [Bos taurus]","gi|75775492|gb|BC105148.1|",2314,0,"Bos taurus platelet-activating factor acetylhydrolase 2, 40kDa, mRNA (cDNA clone MGC:127261 IMAGE:7946914), complete cds","P79106",820,0,"Platelet-activating factor acetylhydrolase 2, cytoplasmic",".",".",".",".","pfam03403","PAF-AH_p_II","Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.","GO:0016042|lipid catabolic process;","GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;","GO:0003847|1-alkyl-2-acetylglycerophosphocholine esterase activity;","K01062","PAFAH; platelet-activating factor acetylhydrolase [EC:3.1.1.47]"]
["gene26117",183,294,420,273.034136143167,938,584,787,849.000872095958,0.321594647446142,-1.63668470008435,{"v":6.68682905370807e-05,"d":"6.69E-05"},0.00207146492650754,"down","yes","ZNF774","protein_coding","chrNC_037348.1:22234280-22244075:-","gi|528998946|ref|XP_005221859.1|",2569,0,"PREDICTED: zinc finger protein 774 isoform X1 [Bos taurus]","gi|982960012|ref|XM_005221802.3|",2055,0,"PREDICTED: Bos taurus zinc finger protein 774 (ZNF774), transcript variant X1, mRNA","Q6NX45",862,0,"Zinc finger protein 774",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;",".","."]
["gene26126",23,5,13,11.6255040801711,184,32,141,131.414108073588,0.0884646576428549,-3.49875498799311,{"v":1.02907711360212e-05,"d":"1.03E-05"},0.000442177697713586,"down","yes","SLC28A1","protein_coding","chrNC_037348.1:22523541-22586295:+","gi|741966423|ref|XP_010815256.1|",3141,0,"PREDICTED: sodium/nucleoside cotransporter 1 isoform X2 [Bos taurus]","gi|982960034|ref|XM_010816954.2|",3784,0,"PREDICTED: Bos taurus solute carrier family 28 (concentrative nucleoside transporter), member 1 (SLC28A1), transcript variant X2, mRNA","O62667",843,0,"Sodium/nucleoside cotransporter 1","all0378",296,{"v":2e-88,"d":"2.00E-88"},"COG1972","pfam07662","Nucleos_tra2_C","Na+ dependent nucleoside transporter C-terminus. This family consists of nucleoside transport proteins. Members include a purine-specific Na+-nucleoside cotransporter localized to the bile canalicular membrane and a Na+-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine, which also transports the anti-viral nucleoside analogues AZT and ddC. This alignment covers the C-terminus of this family of transporters.",".","GO:0005887|integral component of plasma membrane;","GO:0015389|pyrimidine- and adenine-specific:sodium symporter activity;","K11536","SLC28A; pyrimidine nucleoside transport protein"]
["gene26152",588,312,150,301.562624213364,746,852,727,853.931693962437,0.353146072859815,-1.50166304170184,{"v":3.4186626287028e-05,"d":"3.42E-05"},0.00117374083585463,"down","yes","ADAMTSL3","protein_coding","chrNC_037348.1:24111437-24493260:-","gi|926719137|ref|XP_013828452.1|",8490,0,"PREDICTED: ADAMTS-like protein 3 isoform X5 [Capra hircus]","gi|965909325|ref|XM_012169244.2|",6528,0,"PREDICTED: Ovis aries musimon ADAMTS like 3 (ADAMTSL3), transcript variant X8, mRNA","P82987",2841,0,"ADAMTS-like protein 3",".",".",".",".","pfam08686","PLAC","PLAC (protease and lacunin) domain. The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.",".","GO:0005576|extracellular region;GO:0043231|intracellular membrane-bounded organelle;","GO:0008233|peptidase activity;",".","."]
["gene26179",1,7,0,2.55464699128235,94,44,63,74.0229454854689,0.034511555498475,-4.8567766896506,0.000379689593585986,0.00846322171453263,"down","yes","CTXND1","protein_coding","chrNC_037348.1:26151144-26267852:-","gi|4239700|emb|CAA10770.1|",556,{"v":5e-59,"d":"5.00E-59"},"reverse transcriptase-like [Bos taurus]","gi|850491796|gb|CP011903.1|",2350,0,"Ovis canadensis canadensis isolate 43U chromosome 18 sequence","A0A1B0GST9",96.3,{"v":2e-21,"d":"2.00E-21"},"Cortexin domain-containing 1",".",".",".",".","pfam11057","Cortexin","Cortexin of kidney. In the middle of cortexin protein there is a single membrane-spanning domain which indicates that this protein may be a membrane protein involved in intracellular or extracellular signalling of the kidney or brain, since it is expressed specifically in the kidneys and brain only. The protein is highly conserved among species. Cortexin is also thought to be important to neurons of both the developing and adult cerebral cortex.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene26251",4040,2397,4632,3261.04456074922,19119,8194,14684,15453.6941505917,0.211020389621491,-2.24454569034058,{"v":1.79584704112027e-06,"d":"1.80E-06"},0.000100278576053066,"down","yes","DNAJA4","protein_coding","chrNC_037348.1:30653151-30669872:+","gi|803178492|ref|XP_004017863.2|",2255,0,"PREDICTED: dnaJ homolog subfamily A member 4 isoform X1 [Ovis aries]","gi|299890824|ref|NM_001102120.2|",3196,0,"Bos taurus DnaJ heat shock protein family (Hsp40) member A4 (DNAJA4), mRNA","Q8WW22",684,0,"DnaJ homolog subfamily A member 4","YNL064c",292,{"v":1e-87,"d":"1.00E-87"},"COG0484","pfam00226","DnaJ","DnaJ domain. DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.","GO:0090084|negative regulation of inclusion body assembly;GO:0042026|protein refolding;GO:0009408|response to heat;","GO:0005829|cytosol;GO:0016020|membrane;","GO:0005524|ATP binding;GO:0051087|chaperone binding;GO:0031072|heat shock protein binding;GO:0046872|metal ion binding;GO:0051082|unfolded protein binding;","K09505","DNAJA4; DnaJ homolog subfamily A member 4"]
["gene2644",19,39,67,38.3099804406879,323,119,279,265.110049717916,0.144505953212451,-2.79079916622254,{"v":8.93156163729346e-05,"d":"8.93E-05"},0.00265444151118354,"down","yes","IFNLR1","protein_coding","chrNC_037329.1:128718491-128742676:+","gi|528941177|ref|XP_005203317.1|",2168,0,"PREDICTED: interferon lambda receptor 1 isoform X1 [Bos taurus]","gi|982915627|ref|XM_005203260.3|",4250,0,"PREDICTED: Bos taurus interferon, lambda receptor 1 (IFNLR1), transcript variant X1, mRNA","Q8IU57",519,{"v":2e-167,"d":"2.00E-167"},"Interferon lambda receptor 1",".",".",".",".","pfam01108","Tissue_fac","Tissue factor. This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.","GO:0019221|cytokine-mediated signaling pathway;GO:0051607|defense response to virus;GO:0002385|mucosal immune response;GO:0008285|negative regulation of cell proliferation;GO:0050691|regulation of defense response to virus by host;GO:0034342|response to type III interferon;","GO:0016021|integral component of membrane;GO:0032002|interleukin-28 receptor complex;GO:0005886|plasma membrane;","GO:0004896|cytokine receptor activity;","K05140","IL28RA; interleukin 28 receptor alpha"]
["gene2646",12334,6808,15083,10077.9445628873,79529,54661,73343,76260.1445106718,0.132152182867644,-2.91972783951577,{"v":3.45890766218377e-08,"d":"3.46E-08"},{"v":3.30053827791857e-06,"d":"3.30E-06"},"down","yes","MYOM3","protein_coding","chrNC_037329.1:128788339-128840349:+","gi|555977663|ref|XP_005900783.1|",7061,0,"PREDICTED: myomesin-3 [Bos mutus]","gi|942069302|ref|XM_005900721.2|",5494,0,"PREDICTED: Bos mutus myomesin 3 (MYOM3), mRNA","Q5VTT5",2369,0,"Myomesin-3",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0007015|actin filament organization;GO:0045214|sarcomere organization;GO:0006941|striated muscle contraction;GO:0071688|striated muscle myosin thick filament assembly;","GO:0031430|M band;GO:0005859|muscle myosin complex;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0051371|muscle alpha-actinin binding;GO:0042803|protein homodimerization activity;GO:0008307|structural constituent of muscle;GO:0097493|structural molecule activity conferring elasticity;",".","."]
["gene26522",10,4,6,5.75983288683709,82,25,47,56.789398377199,0.101424439269102,-3.30152276834437,0.000461424828108473,0.00994047957283167,"down","yes","GPR68","protein_coding","chrNC_037348.1:55998492-56036608:-","gi|528999765|ref|XP_005222176.1|",1841,0,"PREDICTED: ovarian cancer G-protein coupled receptor 1 isoform X1 [Bos taurus]","gi|982960632|ref|XM_005222119.3|",3347,0,"PREDICTED: Bos taurus G protein-coupled receptor 68 (GPR68), transcript variant X1, mRNA","O46685",688,0,"Ovarian cancer G-protein coupled receptor 1",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0071467|cellular response to pH;GO:0045656|negative regulation of monocyte differentiation;GO:0035774|positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:2001206|positive regulation of osteoclast development;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004930|G-protein coupled receptor activity;","K08408","GPR68; G protein-coupled receptor 68"]
["gene26530",193,189,150,158.30717112065,565,342,422,489.019278476117,0.323723783679791,-1.62716473200817,{"v":9.39014569762428e-05,"d":"9.39E-05"},0.0027648116295038,"down","yes","TC2N","protein_coding","chrNC_037348.1:56487401-56531695:-","gi|300794048|ref|NP_001180133.1|",2424,0,"tandem C2 domains nuclear protein [Bos taurus]","gi|982960755|ref|XM_005222222.3|",4137,0,"PREDICTED: Bos taurus tandem C2 domains, nuclear (TC2N), transcript variant X1, mRNA","Q8N9U0",859,0,"Tandem C2 domains nuclear protein",".",".",".",".","pfam00168","C2","C2 domain.",".","GO:0005634|nucleus;GO:0005886|plasma membrane;",".","K17287","TC2N; tandem C2 domains nuclear protein"]
["gene26581",0,0,1,0.307121633608102,4,18,13,12.7934961524417,0.0240060754268086,-5.38045662231932,0.00317349169717399,0.0430257637571149,"down","yes","SERPINA3","protein_coding","chrNC_037348.1:59332292-59342004:-","gi|528922995|ref|XP_005196374.1|",2093,0,"PREDICTED: serpin A3-5 [Bos taurus]","gi|983004036|ref|XM_005196317.3|",3288,0,"PREDICTED: Bos taurus serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (SERPINA3), transcript variant X2, mRNA","A2I7N1",748,0,"Serpin A3-5","MA2246",159,{"v":1e-40,"d":"1.00E-40"},"COG4826","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.",".","GO:0042583|chromaffin granule;GO:0031410|cytoplasmic vesicle;GO:0005615|extracellular space;","GO:0004867|serine-type endopeptidase inhibitor activity;","K04525","SERPINA; serpin peptidase inhibitor, clade A"]
["gene26589",0,0,0,0,14,10,6,11.0684662832023,{"$error":"#NAME?"},{"$error":"#NAME?"},0.00206626952586349,0.0315761841684046,"down","yes","GSC","protein_coding","chrNC_037348.1:59628000-59629562:-","gi|300798232|ref|NP_001179315.1|",1115,{"v":2e-151,"d":"2.00E-151"},"homeobox protein goosecoid [Bos taurus]","gi|300798231|ref|NM_001192386.1|",774,0,"Bos taurus goosecoid homeobox (GSC), mRNA","Q02591",419,{"v":2e-147,"d":"2.00E-147"},"Homeobox protein goosecoid",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009653|anatomical structure morphogenesis;GO:0021904|dorsal/ventral neural tube patterning;GO:0043583|ear development;GO:0048704|embryonic skeletal system morphogenesis;GO:0030900|forebrain development;GO:0042474|middle ear morphogenesis;GO:0048644|muscle organ morphogenesis;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030178|negative regulation of Wnt signaling pathway;GO:0014036|neural crest cell fate specification;GO:0023019|signal transduction involved in regulation of gene expression;","GO:0016604|nuclear body;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001103|RNA polymerase II repressing transcription factor binding;GO:0001085|RNA polymerase II transcription factor binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09324","GSC; homeobox protein goosecoid"]
["gene26787",5220,4101,4911,4212.69784136064,12450,5675,9908,10312.5865556116,0.408500604445186,-1.29158988180544,0.0032689179468815,0.0439516955431084,"down","yes","EIF5","protein_coding","chrNC_037348.1:67987851-67997279:+","gi|300794424|ref|NP_001180152.1|",1823,0,"eukaryotic translation initiation factor 5 [Bos taurus]","gi|300794423|ref|NM_001193223.1|",4372,0,"Bos taurus eukaryotic translation initiation factor 5 (EIF5), mRNA","P59325",696,0,"Eukaryotic translation initiation factor 5","SPAC2F7.05c",213,{"v":7e-59,"d":"7.00E-59"},"COG1601","pfam01873","eIF-5_eIF-2B","Domain found in IF2B/IF5. This family includes the N terminus of eIF-5, and the C terminus of eIF-2 beta. This region corresponds to the whole of the archaebacterial eIF-2 beta homologue. The region contains a putative zinc binding C4 finger.","GO:0090630|activation of GTPase activity;GO:0001731|formation of translation preinitiation complex;GO:0006446|regulation of translational initiation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005886|plasma membrane;","GO:0045296|cadherin binding;GO:0071074|eukaryotic initiation factor eIF2 binding;GO:0005525|GTP binding;GO:0003743|translation initiation factor activity;","K03262","EIF5; translation initiation factor 5"]
["gene2682",439,277,207,268.7655762682,553,495,589,600.965631820975,0.447222872718724,-1.16093411977864,0.000410473343087079,0.00903643128982828,"down","yes","C1QA","protein_coding","chrNC_037329.1:130189865-130192754:-","gi|62460582|ref|NP_001014945.1|",1044,{"v":1e-139,"d":"1.00E-139"},"complement C1q subcomponent subunit A precursor [Bos taurus]","gi|982915587|ref|XM_005203214.3|",1011,0,"PREDICTED: Bos taurus complement component 1, q subcomponent, A chain (C1QA), transcript variant X1, mRNA","Q5E9E3",406,{"v":5e-141,"d":"5.00E-141"},"Complement C1q subcomponent subunit A",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0006958|complement activation, classical pathway;GO:0045087|innate immune response;","GO:0005581|collagen trimer;GO:0005576|extracellular region;",".","K03986","C1QA; complement C1q subcomponent subunit A"]
["gene26968",168,125,225,153.85178125113,503,245,373,412.56019115847,0.37291959948708,-1.42306347224684,0.00270116007494126,0.0383035775835731,"down","yes","XYLB","protein_coding","chrNC_037349.1:11776962-11823050:+","gi|529000612|ref|XP_005222514.1|",2753,0,"PREDICTED: xylulose kinase isoform X1 [Bos taurus]","gi|982961230|ref|XM_005222457.3|",5030,0,"PREDICTED: Bos taurus xylulokinase homolog (H. influenzae) (XYLB), transcript variant X1, mRNA","O75191",966,0,"Xylulose kinase","SPCPJ732.02c",306,{"v":1e-88,"d":"1.00E-88"},"COG1070","pfam02782","FGGY_C","FGGY family of carbohydrate kinases, C-terminal domain. This domain adopts a ribonuclease H-like fold and is structurally related to the N-terminal domain.","GO:0005975|carbohydrate metabolic process;GO:0042732|D-xylose metabolic process;GO:0006091|generation of precursor metabolites and energy;GO:0019640|glucuronate catabolic process to xylulose 5-phosphate;GO:0005998|xylulose catabolic process;GO:0005997|xylulose metabolic process;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0005524|ATP binding;GO:0004856|xylulokinase activity;","K00854","xylB, XYLB; xylulokinase [EC:2.7.1.17]"]
["gene26971",1,4,1,1.87861558727068,19,25,32,27.8274153687526,0.0675095247753471,-3.88876512647429,0.00052610653482109,0.0109564566021756,"down","yes","SCN5A","protein_coding","chrNC_037349.1:11975423-12080313:-","gi|27806135|ref|NP_776883.1|",8438,0,"sodium channel protein type 5 subunit alpha [Bos taurus]","gi|594108370|ref|XM_006077004.1|",7138,0,"PREDICTED: Bubalus bubalis sodium channel protein type 5 subunit alpha-like (LOC102391734), transcript variant X3, mRNA","Q9JJV9",3050,0,"Sodium channel protein type 5 subunit alpha",".",".",".",".","pfam06512","Na_trans_assoc","Sodium ion transport-associated. Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.","GO:0086014|atrial cardiac muscle cell action potential;GO:0086016|AV node cell action potential;GO:0086067|AV node cell to bundle of His cell communication;GO:0086043|bundle of His cell action potential;GO:0055074|calcium ion homeostasis;GO:0086002|cardiac muscle cell action potential involved in contraction;GO:0060048|cardiac muscle contraction;GO:0003231|cardiac ventricle development;GO:0071277|cellular response to calcium ion;GO:0051899|membrane depolarization;GO:0086010|membrane depolarization during action potential;GO:0098912|membrane depolarization during atrial cardiac muscle cell action potential;GO:0086045|membrane depolarization during AV node cell action potential;GO:0086048|membrane depolarization during bundle of His cell action potential;GO:0086012|membrane depolarization during cardiac muscle cell action potential;GO:0086047|membrane depolarization during Purkinje myocyte cell action potential;GO:0086046|membrane depolarization during SA node cell action potential;GO:0019228|neuronal action potential;GO:0045760|positive regulation of action potential;GO:0050679|positive regulation of epithelial cell proliferation;GO:0010460|positive regulation of heart rate;GO:0010765|positive regulation of sodium ion transport;GO:0060371|regulation of atrial cardiac muscle cell membrane depolarization;GO:0060372|regulation of atrial cardiac muscle cell membrane repolarization;GO:0086004|regulation of cardiac muscle cell contraction;GO:0002027|regulation of heart rate;GO:0086091|regulation of heart rate by cardiac conduction;GO:1902305|regulation of sodium ion transmembrane transport;GO:0060373|regulation of ventricular cardiac muscle cell membrane depolarization;GO:0060307|regulation of ventricular cardiac muscle cell membrane repolarization;GO:0014894|response to denervation involved in regulation of muscle adaptation;GO:0014070|response to organic cyclic compound;GO:0086015|SA node cell action potential;GO:0035725|sodium ion transmembrane transport;GO:0006814|sodium ion transport;GO:0086005|ventricular cardiac muscle cell action potential;","GO:0005901|caveola;GO:0009986|cell surface;GO:0005783|endoplasmic reticulum;GO:0016021|integral component of membrane;GO:0014704|intercalated disc;GO:0005622|intracellular;GO:0016328|lateral plasma membrane;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;GO:0042383|sarcolemma;GO:0034706|sodium channel complex;GO:0030315|T-tubule;GO:0001518|voltage-gated sodium channel complex;GO:0030018|Z disc;","GO:0030506|ankyrin binding;GO:0005516|calmodulin binding;GO:0019899|enzyme binding;GO:0017134|fibroblast growth factor binding;GO:0044325|ion channel binding;GO:0050998|nitric-oxide synthase binding;GO:0019904|protein domain specific binding;GO:0019901|protein kinase binding;GO:0097110|scaffold protein binding;GO:0031625|ubiquitin protein ligase binding;GO:0005244|voltage-gated ion channel activity;GO:0005248|voltage-gated sodium channel activity;GO:0086060|voltage-gated sodium channel activity involved in AV node cell action potential;GO:0086061|voltage-gated sodium channel activity involved in bundle of His cell action potential;GO:0086006|voltage-gated sodium channel activity involved in cardiac muscle cell action potential;GO:0086062|voltage-gated sodium channel activity involved in Purkinje myocyte action potential;GO:0086063|voltage-gated sodium channel activity involved in SA node cell action potential;","K04838","SCN5A; voltage-gated sodium channel type V alpha"]
["gene27068",2,3,1,1.8115211449003,41,23,31,34.955365326388,0.0518238367124938,-4.27024036219212,{"v":8.70529485551807e-05,"d":"8.71E-05"},0.00259259673823368,"down","yes","PRRT3","protein_coding","chrNC_037349.1:16812546-16819775:+","gi|359078155|ref|XP_003587664.1|",3554,0,"PREDICTED: proline-rich transmembrane protein 3 isoform X1 [Bos taurus]","gi|983004424|ref|XM_015468700.1|",3888,0,"PREDICTED: Bos taurus proline-rich transmembrane protein 3 (PRRT3), transcript variant X1, mRNA","Q5FWE3",920,0,"Proline-rich transmembrane protein 3",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene27071",2,4,0,1.83211719049879,32,21,33,31.5794231536516,0.0580161702632917,-4.10740112561617,0.000222203405127079,0.00546053863193857,"down","yes","IL17RE","protein_coding","chrNC_037349.1:16840559-16854979:-","gi|982961563|ref|XP_015314983.1|",2515,0,"PREDICTED: interleukin-17 receptor E isoform X3 [Bos taurus]","gi|983004430|ref|XM_015468702.1|",2533,0,"PREDICTED: Bos taurus interleukin 17 receptor E (IL17RE), transcript variant X3, mRNA","Q8NFR9",684,0,"Interleukin-17 receptor E",".",".",".",".","pfam15037","IL17_R_N","Interleukin-17 receptor extracellular region. This domain is found at the N-terminus (extracellular region) of interleukin-17 receptor C and Interleukin-17 receptor E. This is the presumed ligand-binding domain. Human putative interleukin-17 receptor E-like consists only of this domain.","GO:0006954|inflammatory response;GO:0097400|interleukin-17-mediated signaling pathway;","GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;","GO:0030368|interleukin-17 receptor activity;","K05168","IL17RE; interleukin 17 receptor E"]
["gene27073",14,104,183,93.9346229034751,1463,1107,1474,1485.15199239188,0.063249164654313,-3.98280976383399,{"v":3.88978003922717e-13,"d":"3.89E-13"},{"v":1.02758624351102e-10,"d":"1.03E-10"},"down","yes","CIDEC","protein_coding","chrNC_037349.1:16864388-16873816:+","gi|982961315|ref|XP_015314928.1|",1231,{"v":3e-166,"d":"3.00E-166"},"PREDICTED: cell death activator CIDE-3 isoform X2 [Bos taurus]","gi|982961316|ref|XM_005222498.3|",1241,0,"PREDICTED: Bos taurus cell death-inducing DFFA-like effector c (CIDEC), transcript variant X3, mRNA","F1MN90",452,{"v":1e-157,"d":"1.00E-157"},"Cell death activator CIDE-3",".",".",".",".","pfam02017","CIDE-N","CIDE-N domain. This domain is found in CAD nuclease, and in ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.","GO:0097194|execution phase of apoptosis;GO:0034389|lipid particle organization;GO:0042981|regulation of apoptotic process;GO:0006355|regulation of transcription, DNA-templated;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005811|lipid particle;GO:0005634|nucleus;",".",".","."]
["gene27154",9,4,1,3.96360148196037,15,73,28,42.5038547656934,0.0932527532810872,-3.42270986830677,0.00176213360657206,0.0281171671189823,"down","yes","MDFIC2","protein_coding","chrNC_037349.1:31388665-31402071:+","gi|594088544|ref|XP_006067720.1|",663,{"v":8e-77,"d":"8.00E-77"},"PREDICTED: myoD family inhibitor domain-containing protein-like [Bubalus bubalis]","gi|850492351|gb|CP011904.1|",1615,0,"Ovis canadensis canadensis isolate 43U chromosome 19 sequence",".",".",".",".",".",".",".",".","pfam15316","MDFI","MyoD family inhibitor. Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors. They affect axin-mediated regulation of the Wnt and JNK signaling pathways, and regulate expression from viral promoters.",".",".",".",".","."]
["gene2718",4,0,1,1.34961458095295,20,22,27,25.295356309703,0.0533542427483124,-4.22825319054185,0.000684050447515615,0.0135909772409944,"down","yes","CDA","protein_coding","chrNC_037329.1:132021359-132042291:-","gi|300797321|ref|NP_001180039.1|",777,{"v":1e-100,"d":"1.00E-100"},"cytidine deaminase [Bos taurus]","gi|300797320|ref|NM_001193110.1|",1016,0,"Bos taurus cytidine deaminase (CDA), mRNA","P56389",277,{"v":1e-91,"d":"1.00E-91"},"Cytidine deaminase","CAC1544",135,{"v":1e-37,"d":"1.00E-37"},"COG0295","pfam00383","dCMP_cyt_deam_1","Cytidine and deoxycytidylate deaminase zinc-binding region.","GO:0009972|cytidine deamination;GO:0030308|negative regulation of cell growth;GO:0045980|negative regulation of nucleotide metabolic process;GO:0051289|protein homotetramerization;","GO:0005829|cytosol;","GO:0004126|cytidine deaminase activity;GO:0042802|identical protein binding;GO:0001882|nucleoside binding;GO:0042803|protein homodimerization activity;GO:0008270|zinc ion binding;","K01489","cdd, CDA; cytidine deaminase [EC:3.5.4.5]"]
["gene27198",2,0,0,0.521246473672423,78,4,35,43.2559124062422,0.0120502942760075,-6.37478781134,0.00135624753754884,0.0230190948803128,"down","yes","CADPS","protein_coding","chrNC_037349.1:38429852-38901788:+","gi|803231880|ref|XP_011976125.1|",6757,0,"PREDICTED: calcium-dependent secretion activator 1 isoform X4 [Ovis aries musimon]","gi|965810184|ref|XM_012120735.2|",4702,0,"PREDICTED: Ovis aries musimon Ca++-dependent secretion activator (CADPS), transcript variant X4, mRNA","Q9ULU8",2379,0,"Calcium-dependent secretion activator 1",".",".",".",".","pfam06292","DUF1041","Domain of Unknown Function (DUF1041). This family consists of several eukaryotic domains of unknown function. Members of this family are often found in tandem repeats and co-occur with pfam00168, pfam00130 and pfam00169 domains.","GO:0050432|catecholamine secretion;GO:0006887|exocytosis;GO:0015031|protein transport;GO:0016082|synaptic vesicle priming;GO:0016050|vesicle organization;","GO:0030054|cell junction;GO:0030659|cytoplasmic vesicle membrane;GO:0005829|cytosol;GO:0098793|presynapse;","GO:0008289|lipid binding;GO:0046872|metal ion binding;GO:0019901|protein kinase binding;",".","."]
["gene27247",212,115,105,125.187430846886,782,601,761,787.546543600152,0.158958771217013,-2.65327546946427,{"v":1.27168142693256e-12,"d":"1.27E-12"},{"v":3.127788171708e-10,"d":"3.13E-10"},"down","yes","WNT5A","protein_coding","chrNC_037349.1:45540765-45561515:+","gi|594059727|ref|XP_006053986.1|",2061,0,"PREDICTED: LOW QUALITY PROTEIN: protein Wnt-5a, partial [Bubalus bubalis]","gi|982962069|ref|XM_005222857.3|",7592,0,"PREDICTED: Bos taurus wingless-type MMTV integration site family member 5A (WNT5A), transcript variant X1, mRNA","Q27Q52",782,0,"Protein Wnt-5a",".",".",".",".","pfam00110","wnt","wnt family. Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.","GO:0051216|cartilage development;GO:0030154|cell differentiation;GO:0016055|Wnt signaling pathway;","GO:0005576|extracellular region;","GO:0005102|receptor binding;","K00444","WNT5; wingless-type MMTV integration site family, member 5"]
["gene27250",30,40,71,42.7330402595252,1233,459,925,963.203271183366,0.0443655472712675,-4.49441642480719,{"v":7.45021814911956e-12,"d":"7.45E-12"},{"v":1.55154871541993e-09,"d":"1.55E-09"},"down","yes","CACNA2D3","protein_coding","chrNC_037349.1:45924532-46818527:-","gi|556717267|ref|XP_005954547.1|",5430,0,"PREDICTED: voltage-dependent calcium channel subunit alpha-2/delta-3 [Pantholops hodgsonii]","gi|332164671|ref|NM_001206751.1|",3214,0,"Bos taurus calcium channel, voltage-dependent, alpha 2/delta subunit 3 (CACNA2D3), mRNA","Q8IZS8",2061,0,"Voltage-dependent calcium channel subunit alpha-2/delta-3",".",".",".",".","pfam08399","VWA_N","VWA N-terminal. This domain is found at the N-terminus of proteins containing von Willebrand factor type A (VWA, pfam00092) and Cache (pfam02743) domains. It has been found in vertebrates, Drosophila and C. elegans but has not yet been identified in other eukaryotes. It is probably involved in the function of some voltage-dependent calcium channel subunits.","GO:0034765|regulation of ion transmembrane transport;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005262|calcium channel activity;GO:0046872|metal ion binding;GO:0005244|voltage-gated ion channel activity;","K04860","CACNA2D3; voltage-dependent calcium channel alpha-2/delta-3"]
["gene27274",2229,1792,3623,2280.90095460828,5975,9315,8731,8803.40783307661,0.259092955575494,-1.94845830397166,{"v":1.80105564805166e-07,"d":"1.80E-07"},{"v":1.38880861336654e-05,"d":"1.39E-05"},"down","yes","MUSTN1","protein_coding","chrNC_037349.1:48056089-48057236:+","gi|94966972|ref|NP_001035679.1|",418,{"v":9e-50,"d":"9.00E-50"},"musculoskeletal embryonic nuclear protein 1 [Bos taurus]","gi|402744280|ref|NM_001040589.2|",530,0,"Bos taurus musculoskeletal, embryonic nuclear protein 1 (MUSTN1), mRNA","Q32KU9",165,{"v":3e-51,"d":"3.00E-51"},"Musculoskeletal embryonic nuclear protein 1",".",".",".",".","pfam14967","FAM70","FAM70 protein. This family of proteins is found in eukaryotes. Proteins in this family are typically between 241 and 349 amino acids in length. The function of this family is unknown.","GO:0002062|chondrocyte differentiation;GO:0035988|chondrocyte proliferation;GO:0032332|positive regulation of chondrocyte differentiation;GO:1902732|positive regulation of chondrocyte proliferation;GO:0010628|positive regulation of gene expression;GO:1902730|positive regulation of proteoglycan biosynthetic process;GO:0042246|tissue regeneration;","GO:0005634|nucleus;",".",".","."]
["gene27275",712,266,570,447.795978452954,875,750,901,927.524328150227,0.482786235209591,-1.0505435511017,0.000677168369071113,0.0134731918808351,"down","yes","ITIH4","protein_coding","chrNC_037349.1:48057333-48075272:+","gi|75832116|ref|NP_001015590.2|",4426,0,"inter-alpha-trypsin inhibitor heavy chain H4 precursor [Bos taurus]","gi|982961936|ref|XM_010817701.2|",3686,0,"PREDICTED: Bos taurus inter-alpha-trypsin inhibitor heavy chain family member 4 (ITIH4), transcript variant X1, mRNA","Q3T052",1709,0,"Inter-alpha-trypsin inhibitor heavy chain H4","alr4412",102,{"v":5e-21,"d":"5.00E-21"},"COG2304","pfam06668","ITI_HC_C","Inter-alpha-trypsin inhibitor heavy chain C-terminus. This family represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2, HC3). The heavy chains do not have any protease inhibitory properties but have the capacity to interact in vitro and in vivo with hyaluronic acid, which promotes the stability of the extra-cellular matrix. All family members contain the pfam00092 domain.","GO:0006953|acute-phase response;GO:0030212|hyaluronan metabolic process;","GO:0005576|extracellular region;","GO:0004867|serine-type endopeptidase inhibitor activity;",".","."]
["gene27302",2225,1422,2674,1867.14449006041,7201,3607,6610,6401.2589714422,0.291683948171799,-1.7775221002527,{"v":1.87831283833338e-05,"d":"1.88E-05"},0.000722239131947299,"down","yes","TWF2","protein_coding","chrNC_037349.1:48665271-48674428:+","gi|741968861|ref|XP_010815970.1|",1763,0,"PREDICTED: twinfilin-2 isoform X1 [Bos taurus]","gi|742171136|ref|XM_010851749.1|",1789,0,"PREDICTED: Bison bison bison twinfilin actin-binding protein 2 (TWF2), transcript variant X2, mRNA","Q6IBS0",585,0,"Twinfilin-2",".",".",".",".","pfam00241","Cofilin_ADF","Cofilin/tropomyosin-type actin-binding protein. Severs actin filaments and binds to actin monomers.","GO:0051016|barbed-end actin filament capping;GO:0030030|cell projection organization;GO:0071363|cellular response to growth factor stimulus;GO:0071300|cellular response to retinoic acid;GO:0030837|negative regulation of actin filament polymerization;GO:0045773|positive regulation of axon extension;GO:0010592|positive regulation of lamellipodium assembly;GO:0010976|positive regulation of neuron projection development;GO:0032956|regulation of actin cytoskeleton organization;GO:0032532|regulation of microvillus length;GO:0042989|sequestering of actin monomers;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0070062|extracellular exosome;GO:0030175|filopodium;GO:0030426|growth cone;GO:0030027|lamellipodium;GO:0030016|myofibril;GO:0048471|perinuclear region of cytoplasm;GO:0032420|stereocilium;","GO:0003785|actin monomer binding;GO:0005524|ATP binding;GO:0045296|cadherin binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;GO:0005080|protein kinase C binding;GO:0003723|RNA binding;","K08870","TWF; twinfilin"]
["gene2731",1,0,1,0.567744870444313,32,0,26,21.3458739857006,0.0265974057011973,-5.23257065700111,0.00101795627349736,0.0182892383118093,"down","yes","PLA2G2D1","protein_coding","chrNC_037329.1:132596456-132609998:+","gi|296489958|tpg|DAA32071.1|",686,{"v":1e-82,"d":"1.00E-82"},"TPA: calcium-dependent phospholipase A2 PLA2G2D1 [Bos taurus]","gi|57527700|ref|NM_001009572.1|",913,0,"Bos taurus calcium-dependent phospholipase A2 PLA2G2D1 (PLA2G2D1), mRNA","Q9UNK4",158,{"v":2e-43,"d":"2.00E-43"},"Group IID secretory phospholipase A2",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0050482|arachidonic acid secretion;GO:0002361|CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;GO:0006954|inflammatory response;GO:0016042|lipid catabolic process;GO:0042130|negative regulation of T cell proliferation;GO:0006654|phosphatidic acid biosynthetic process;GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;GO:0036148|phosphatidylglycerol acyl-chain remodeling;GO:0036149|phosphatidylinositol acyl-chain remodeling;GO:0036150|phosphatidylserine acyl-chain remodeling;GO:0006644|phospholipid metabolic process;","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;GO:0043395|heparan sulfate proteoglycan binding;GO:0008201|heparin binding;GO:0004623|phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["gene27364",13,7,8,8.1390989021817,37,35,45,42.9177642318671,0.189644056438016,-2.39863393750127,0.00357308849387311,0.0470871999162558,"down","yes","MST1R","protein_coding","chrNC_037349.1:50356408-50370270:+","gi|982962444|ref|XP_015315131.1|",6335,0,"PREDICTED: macrophage-stimulating protein receptor isoform X2 [Bos taurus]","gi|983004729|ref|XM_015468789.1|",5962,0,"PREDICTED: Bos taurus macrophage stimulating 1 receptor (MST1R), transcript variant X2, mRNA","Q04912",2002,0,"Macrophage-stimulating protein receptor",".",".",".",".","pfam07714","Pkinase_Tyr","Protein tyrosine kinase.","GO:0006952|defense response;GO:0048012|hepatocyte growth factor receptor signaling pathway;GO:0045087|innate immune response;GO:0008284|positive regulation of cell proliferation;GO:0043406|positive regulation of MAP kinase activity;GO:0051897|positive regulation of protein kinase B signaling;GO:0009615|response to virus;GO:0007165|signal transduction;GO:0007338|single fertilization;","GO:0009986|cell surface;GO:0005887|integral component of plasma membrane;GO:0005886|plasma membrane;GO:0001725|stress fiber;GO:0005773|vacuole;","GO:0005524|ATP binding;GO:0019899|enzyme binding;GO:0005011|macrophage colony-stimulating factor receptor activity;","K05100","MST1R, RON; macrophage-stimulating 1 receptor [EC:2.7.10.1]"]
["gene27376",55,15,29,28.1565705887255,101,67,95,96.631168634024,0.291381869708771,-1.7790169817093,0.00207197094825536,0.0316125150399324,"down","yes","MST1","protein_coding","chrNC_037349.1:50509517-50514784:+","gi|767923300|ref|XP_011532034.1|",1616,0,"PREDICTED: hepatocyte growth factor-like protein isoform X3 [Homo sapiens]","gi|982961957|ref|XM_005222803.3|",1375,0,"PREDICTED: Bos taurus macrophage stimulating 1 (MST1), transcript variant X1, mRNA","P26928",379,0,"Hepatocyte growth factor-like protein",".",".",".",".","pfam00051","Kringle","Kringle domain. Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.","GO:0071456|cellular response to hypoxia;GO:0007566|embryo implantation;GO:0030317|sperm motility;GO:0060763|mammary duct terminal end bud growth;GO:0030879|mammary gland development;GO:1904036|negative regulation of epithelial cell apoptotic process;GO:0045721|negative regulation of gluconeogenesis;GO:0010628|positive regulation of gene expression;GO:0033601|positive regulation of mammary gland epithelial cell proliferation;GO:2000479|regulation of cAMP-dependent protein kinase activity;GO:0046425|regulation of JAK-STAT cascade;GO:0010758|regulation of macrophage chemotaxis;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0005615|extracellular space;GO:0005773|vacuole;","GO:0019899|enzyme binding;GO:0030971|receptor tyrosine kinase binding;GO:0004252|serine-type endopeptidase activity;",".","."]
["gene27401",983,1439,1394,1155.90593943798,2619,1767,2388,2489.3689202249,0.464336936983028,-1.10675604619755,0.000351188811897955,0.00795971094950946,"down","yes","IMPDH2","protein_coding","chrNC_037349.1:50962811-50967696:+","gi|741968957|ref|XP_010815999.1|",2846,0,"PREDICTED: inosine-5'-monophosphate dehydrogenase 2 isoform X2 [Bos taurus]","gi|982961923|ref|XM_010817697.2|",1777,0,"PREDICTED: Bos taurus IMP (inosine 5'-monophosphate) dehydrogenase 2 (IMPDH2), transcript variant X2, mRNA","Q3SWY3",969,0,"Inosine-5'-monophosphate dehydrogenase 2",".",".",".",".","pfam00478","IMPDH","IMP dehydrogenase / GMP reductase domain. This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.","GO:0071353|cellular response to interleukin-4;GO:0007623|circadian rhythm;GO:0006177|GMP biosynthetic process;GO:0006183|GTP biosynthetic process;GO:0046651|lymphocyte proliferation;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003938|IMP dehydrogenase activity;GO:0046872|metal ion binding;GO:0000166|nucleotide binding;GO:0003723|RNA binding;","K00088","guaB; IMP dehydrogenase [EC:1.1.1.205]"]
["gene27485",2,0,0,0.521246473672423,88,14,62,60.409736986223,0.00862851751516975,-6.85667157661776,0.000337074665713258,0.00768751182051557,"down","yes","TDGF1","protein_coding","chrNC_037349.1:52867447-52872205:-","gi|440901827|gb|ELR52705.1|",989,{"v":5e-129,"d":"5.00E-129"},"Teratocarcinoma-derived growth factor 1, partial [Bos mutus]","gi|742212612|ref|XM_010862382.1|",1607,0,"PREDICTED: Bison bison bison teratocarcinoma-derived growth factor 1 (TDGF1), mRNA","P13385",304,{"v":6e-99,"d":"6.00E-99"},"Teratocarcinoma-derived growth factor 1",".",".",".",".","pfam09443","CFC","Cripto_Frl-1_Cryptic (CFC). CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumors and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain.","GO:0000187|activation of MAPK activity;GO:0008595|anterior/posterior axis specification, embryo;GO:0030154|cell differentiation;GO:0002042|cell migration involved in sprouting angiogenesis;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0035729|cellular response to hepatocyte growth factor stimulus;GO:0071346|cellular response to interferon-gamma;GO:0071354|cellular response to interleukin-6;GO:0071356|cellular response to tumor necrosis factor;GO:0009792|embryo development ending in birth or egg hatching;GO:0007507|heart development;GO:0030879|mammary gland development;GO:0001763|morphogenesis of a branching structure;GO:0043066|negative regulation of apoptotic process;GO:0018105|peptidyl-serine phosphorylation;GO:0030335|positive regulation of cell migration;GO:0008284|positive regulation of cell proliferation;GO:0010595|positive regulation of endothelial cell migration;GO:0050731|positive regulation of peptidyl-tyrosine phosphorylation;GO:0009966|regulation of signal transduction;GO:0035019|somatic stem cell population maintenance;","GO:0031225|anchored component of membrane;GO:0016324|apical plasma membrane;GO:0009986|cell surface;GO:0005615|extracellular space;GO:0019897|extrinsic component of plasma membrane;GO:0045121|membrane raft;GO:0005886|plasma membrane;","GO:0008083|growth factor activity;GO:0005102|receptor binding;",".","."]
["gene27490",10,13,7,9.01641363330452,53,62,51,60.9725553682597,0.147876591014556,-2.75753440418223,0.000250026372877386,0.00601475754179149,"down","yes","CCRL2","protein_coding","chrNC_037349.1:52998332-53015575:-","gi|440901823|gb|ELR52701.1|",1633,0,"Chemokine C-C motif receptor-like 2, partial [Bos mutus]","gi|982962564|ref|XM_015459667.1|",1571,0,"PREDICTED: Bos taurus chemokine (C-C motif) receptor-like 2 (CCRL2), transcript variant X1, mRNA","Q0II78",632,0,"Chemokine C-C motif receptor-like 2",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0006935|chemotaxis;GO:0006954|inflammatory response;","GO:0005887|integral component of plasma membrane;","GO:0048020|CCR chemokine receptor binding;GO:0004950|chemokine receptor activity;","K08373","CCRL2; C-C chemokine receptor-like 2"]
["gene27515",3,0,2,1.39611297772484,35,15,12,22.9183713527515,0.0609167622007847,-4.03701692688924,0.00202934062844312,0.0311453025659552,"down","yes","CDCP1","protein_coding","chrNC_037349.1:54085580-54142119:+","gi|528923734|ref|XP_612363.6|",3931,0,"PREDICTED: CUB domain-containing protein 1 [Bos taurus]","gi|983004776|ref|XM_612363.8|",5833,0,"PREDICTED: Bos taurus CUB domain containing protein 1 (CDCP1), mRNA","Q9H5V8",1227,0,"CUB domain-containing protein 1",".",".",".",".","pfam15483","DUF4641","Domain of unknown function (DUF4641). This family of proteins is found in eukaryotes. Proteins in this family are typically between 201 and 519 amino acids in length.",".","GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".","K06732","CDCP1; CUB domain-containing protein 1"]
["gene27682",0,2,1,0.962556992021285,1,53,14,24.8777296849708,0.0386915126183233,-4.69183905871144,0.001115521859269,0.0196462680041998,"down","yes","TINAG","protein_coding","chrNC_037350.1:6029291-6135382:-","gi|741970014|ref|XP_010816338.1|",2539,0,"PREDICTED: tubulointerstitial nephritis antigen isoform X1 [Bos taurus]","gi|982962995|ref|XM_010818036.2|",2052,0,"PREDICTED: Bos taurus tubulointerstitial nephritis antigen (TINAG), transcript variant X1, mRNA","Q3SZI1",974,0,"Tubulointerstitial nephritis antigen",".",".",".",".","pfam00112","Peptidase_C1","Papain family cysteine protease.","GO:0007155|cell adhesion;GO:0006955|immune response;","GO:0005604|basement membrane;GO:0005615|extracellular space;","GO:0008234|cysteine-type peptidase activity;GO:0030247|polysaccharide binding;GO:0005044|scavenger receptor activity;",".","."]
["gene27690",395,367,483,371.558315851836,913,580,769,831.69120757322,0.446750323279238,-1.16245932165151,0.000989298448438151,0.0179552633793822,"down","yes","GCLC","protein_coding","chrNC_037350.1:6982199-7026875:+","gi|529002564|ref|XP_005223293.1|",3402,0,"PREDICTED: glutamate--cysteine ligase catalytic subunit isoform X1 [Bos taurus]","gi|982962992|ref|XM_005223236.3|",3712,0,"PREDICTED: Bos taurus glutamate-cysteine ligase, catalytic subunit (GCLC), transcript variant X1, mRNA","P48506",1244,0,"Glutamate--cysteine ligase catalytic subunit",".",".",".",".","pfam03074","GCS","Glutamate-cysteine ligase. This family represents the catalytic subunit of glutamate-cysteine ligase (E.C. 6.3.2.2), also known as gamma-glutamylcysteine synthetase (GCS).  This enzyme catalyses the rate limiting step in the biosynthesis of glutathione. The eukaryotic enzyme is a dimer of a heavy chain and a light chain with all the catalytic activity exhibited by the heavy chain (this family).","GO:0007568|aging;GO:0008637|apoptotic mitochondrial changes;GO:0045454|cell redox homeostasis;GO:0044344|cellular response to fibroblast growth factor stimulus;GO:0071372|cellular response to follicle-stimulating hormone stimulus;GO:0071333|cellular response to glucose stimulus;GO:0035729|cellular response to hepatocyte growth factor stimulus;GO:0032869|cellular response to insulin stimulus;GO:0071260|cellular response to mechanical stimulus;GO:0097069|cellular response to thyroxine stimulus;GO:0006534|cysteine metabolic process;GO:0006536|glutamate metabolic process;GO:0006750|glutathione biosynthetic process;GO:0019852|L-ascorbic acid metabolic process;GO:0043066|negative regulation of apoptotic process;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:2000490|negative regulation of hepatic stellate cell activation;GO:0043524|negative regulation of neuron apoptotic process;GO:0031397|negative regulation of protein ubiquitination;GO:0045892|negative regulation of transcription, DNA-templated;GO:0032436|positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0050880|regulation of blood vessel size;GO:0051900|regulation of mitochondrial depolarization;GO:0014823|response to activity;GO:0046685|response to arsenic-containing substance;GO:0046686|response to cadmium ion;GO:0009408|response to heat;GO:0009725|response to hormone;GO:0044752|response to human chorionic gonadotropin;GO:0070555|response to interleukin-1;GO:0051409|response to nitrosative stress;GO:0007584|response to nutrient;GO:0006979|response to oxidative stress;GO:0009410|response to xenobiotic stimulus;","GO:0005829|cytosol;GO:0017109|glutamate-cysteine ligase complex;","GO:0043531|ADP binding;GO:0005524|ATP binding;GO:0050662|coenzyme binding;GO:0016595|glutamate binding;GO:0004357|glutamate-cysteine ligase activity;GO:0000287|magnesium ion binding;GO:0046982|protein heterodimerization activity;","K11204","GCLC; glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]"]
["gene2780",63,16,24,29.0336659945812,560,83,367,372.247148791999,0.0779956705882101,-3.68046214521354,{"v":1.00253838616063e-05,"d":"1.00E-05"},0.000432075871533971,"down","yes","PADI2","protein_coding","chrNC_037329.1:135473392-135529995:+","gi|741918568|ref|XP_010800918.1|",3113,0,"PREDICTED: protein-arginine deiminase type-2 isoform X5 [Bos taurus]","gi|982915642|ref|XM_010802617.2|",3234,0,"PREDICTED: Bos taurus peptidyl arginine deiminase, type II (PADI2), transcript variant X6, mRNA","P20717",981,0,"Protein-arginine deiminase type-2",".",".",".",".","pfam03068","PAD","Protein-arginine deiminase (PAD). Members of this family are found in mammals. In the presence of calcium ions, PAD enzymes EC:3.5.3.15 catalyse the post-translational modification reaction responsible for the formation of citrulline residues: Protein L-arginine + H2O <=> Protein L-citrulline + NH3. Several types are recognized (and included in the family) on the basis of molecular mass, substrate specificity, and tissue localisation. The expression of type I PAD is known to be under the control of oestrogen.","GO:0036414|histone citrullination;GO:0018101|protein citrullination;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005509|calcium ion binding;GO:0004668|protein-arginine deiminase activity;","K01481","E3.5.3.15; protein-arginine deiminase [EC:3.5.3.15]"]
["gene27809",1013,497,333,529.158529472256,1326,1243,1366,1444.87100146616,0.366232368796453,-1.44916878808201,{"v":1.46845835152496e-05,"d":"1.47E-05"},0.000591759678352524,"down","yes","PI16","protein_coding","chrNC_037350.1:10861065-10877631:+","gi|594052336|ref|XP_006050484.1|",2153,0,"PREDICTED: peptidase inhibitor 16 isoform X3 [Bubalus bubalis]","gi|982963206|ref|XM_005223312.3|",2478,0,"PREDICTED: Bos taurus peptidase inhibitor 16 (PI16), transcript variant X3, mRNA","Q58D34",714,0,"Peptidase inhibitor 16","YJL079c",70.5,{"v":5e-12,"d":"5.00E-12"},"COG2340","pfam00188","CAP","Cysteine-rich secretory protein family. This is a large family of cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) that are found in a wide range of organisms, including prokaryotes and non-vertebrate eukaryotes, The nine subfamilies of the mammalian CAP 'super'family include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumor suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP 'super'family results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences. The Ca++-chelating function would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how helothermine from Heloderma horridum horridum blocks the Ca++ transporting ryanodine receptors.",".","GO:0005576|extracellular region;","GO:0030414|peptidase inhibitor activity;",".","."]
["gene27873",3,1,0,1.10958738971523,50,61,58,62.0110737478883,0.0178933748869816,-5.80443066859418,{"v":3.36609442785486e-08,"d":"3.37E-08"},{"v":3.23360404448239e-06,"d":"3.23E-06"},"down","yes","MDFI","protein_coding","chrNC_037350.1:15457487-15474727:+","gi|529002947|ref|XP_005223441.1|",646,{"v":2e-77,"d":"2.00E-77"},"PREDICTED: myoD family inhibitor isoform X2 [Bos taurus]","gi|594091696|ref|XM_006069158.1|",1428,0,"PREDICTED: Bubalus bubalis MyoD family inhibitor (MDFI), transcript variant X3, mRNA","Q99750",207,{"v":3e-61,"d":"3.00E-61"},"MyoD family inhibitor",".",".",".",".","pfam15316","MDFI","MyoD family inhibitor. Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors. They affect axin-mediated regulation of the Wnt and JNK signaling pathways, and regulate expression from viral promoters.","GO:0042994|cytoplasmic sequestering of transcription factor;GO:0009950|dorsal/ventral axis specification;GO:0048704|embryonic skeletal system morphogenesis;GO:0043392|negative regulation of DNA binding;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0030178|negative regulation of Wnt signaling pathway;GO:0060707|trophoblast giant cell differentiation;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0042802|identical protein binding;GO:0008134|transcription factor binding;",".","."]
["gene27962",13333,12670,18941,13444.2634744558,26811,26081,25937,28955.0528605724,0.464314934570975,-1.10682440931992,0.00314214667576977,0.0426898032411369,"down","yes","HSP90AB1","protein_coding","chrNC_037350.1:17752495-17758156:+","gi|118601868|ref|NP_001073105.1|",3234,0,"heat shock protein HSP 90-beta [Bos taurus]","gi|118601867|ref|NM_001079637.1|",2526,0,"Bos taurus heat shock protein 90kDa alpha family class B member 1 (HSP90AB1), mRNA","Q76LV1",1250,0,"Heat shock protein HSP 90-beta","SPAC926.04c",538,{"v":7e-179,"d":"7.00E-179"},"COG0326","pfam00183","HSP90","Hsp90 protein.","GO:0071157|negative regulation of cell cycle arrest;GO:0032435|negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:1901389|negative regulation of transforming growth factor beta activation;GO:0030511|positive regulation of transforming growth factor beta receptor signaling pathway;GO:0006457|protein folding;GO:0006950|response to stress;","GO:0034751|aryl hydrocarbon receptor complex;GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0042470|melanosome;GO:0005739|mitochondrion;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005524|ATP binding;GO:0046983|protein dimerization activity;GO:0051082|unfolded protein binding;","K04079","htpG, HSP90A; molecular chaperone HtpG"]
["gene27974",126,102,89,93.5995565115561,331,148,254,269.718511728758,0.347026816630533,-1.52688094296272,0.00362481354671062,0.0474619345117947,"down","yes","RUNX2","protein_coding","chrNC_037350.1:18593752-18945540:+","gi|741900145|ref|XP_010797443.1|",1824,0,"PREDICTED: runt-related transcription factor 2 isoform X3 [Bos taurus]","gi|983005213|ref|XM_010799141.2|",5633,0,"PREDICTED: Bos taurus runt-related transcription factor 2 (RUNX2), transcript variant X3, mRNA","Q13950",653,0,"Runt-related transcription factor 2",".",".",".",".","pfam00853","Runt","Runt domain.","GO:0030509|BMP signaling pathway;GO:0048469|cell maturation;GO:0071773|cellular response to BMP stimulus;GO:0002063|chondrocyte development;GO:0002062|chondrocyte differentiation;GO:0048701|embryonic cranial skeleton morphogenesis;GO:0035115|embryonic forelimb morphogenesis;GO:0001958|endochondral ossification;GO:0030097|hemopoiesis;GO:0045879|negative regulation of smoothened signaling pathway;GO:0045892|negative regulation of transcription, DNA-templated;GO:0030182|neuron differentiation;GO:0042475|odontogenesis of dentin-containing tooth;GO:0001503|ossification;GO:0002076|osteoblast development;GO:0001649|osteoblast differentiation;GO:0002051|osteoblast fate commitment;GO:0008284|positive regulation of cell proliferation;GO:0032332|positive regulation of chondrocyte differentiation;GO:0045669|positive regulation of osteoblast differentiation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:1901522|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045595|regulation of cell differentiation;GO:0040036|regulation of fibroblast growth factor receptor signaling pathway;GO:0042487|regulation of odontogenesis of dentin-containing tooth;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0048863|stem cell differentiation;GO:0030217|T cell differentiation;GO:0006367|transcription initiation from RNA polymerase II promoter;","GO:0005829|cytosol;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0005524|ATP binding;GO:0043425|bHLH transcription factor binding;GO:0003682|chromatin binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0019904|protein domain specific binding;GO:0070491|repressing transcription factor binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09278","RUNX2, AML3; runt-related transcription factor 2"]
["gene27986",335,287,492,332.467602007609,560,803,632,732.136013904507,0.454106335016287,-1.13889793164894,0.000273450590541764,0.00649610224708333,"down","yes","PLA2G7","protein_coding","chrNC_037350.1:19925024-19963288:-","gi|99028959|ref|NP_777003.2|",2393,0,"platelet-activating factor acetylhydrolase precursor [Bos taurus]","gi|741970427|ref|XM_005223377.2|",1933,0,"PREDICTED: Bos taurus phospholipase A2 group VII (PLA2G7), transcript variant X1, mRNA","Q28017",921,0,"Platelet-activating factor acetylhydrolase",".",".",".",".","pfam03403","PAF-AH_p_II","Platelet-activating factor acetylhydrolase, isoform II. Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in pfam02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted.","GO:0016042|lipid catabolic process;","GO:0005615|extracellular space;","GO:0003847|1-alkyl-2-acetylglycerophosphocholine esterase activity;",".","."]
["gene2799",57,23,65,42.3559373059423,168,99,145,151.465877306736,0.279640127922453,-1.83835669482925,0.00022756253989815,0.00557782373353446,"down","yes","CLCNKA","protein_coding","chrNC_037329.1:136037153-136049967:-","gi|528901448|ref|XP_005197718.1|",3405,0,"PREDICTED: chloride channel protein ClC-Ka isoform X1 [Bos taurus]","gi|741873890|ref|XM_005197661.2|",2543,0,"PREDICTED: Bos taurus chloride channel Ka (CLCNKA), transcript variant X1, mRNA","P51803",1161,0,"Chloride channel protein ClC-Ka","SPBC19C7.11_1",62.4,{"v":4e-09,"d":"4.00E-09"},"COG0038","pfam00654","Voltage_CLC","Voltage gated chloride channel. This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney. These proteins contain two pfam00571 domains.","GO:0034765|regulation of ion transmembrane transport;","GO:0034707|chloride channel complex;","GO:0046872|metal ion binding;GO:0005247|voltage-gated chloride channel activity;","K05017","CLCNKA; chloride channel Ka"]
["gene2800",18719,19760,38624,23216.5736879386,70913,43184,66297,66284.4273443054,0.350256834344261,-1.51351489354353,0.00126906743065865,0.0218513958141954,"down","yes","HSPB7","protein_coding","chrNC_037329.1:136054093-136057924:+","gi|359063499|ref|XP_003585853.1|",794,{"v":8e-98,"d":"8.00E-98"},"PREDICTED: heat shock protein beta-7 [Bos taurus]","gi|982978085|ref|XM_005199606.3|",2172,0,"PREDICTED: Bos taurus heat shock protein family B (small) member 7 (HSPB7), mRNA","Q9UBY9",274,{"v":1e-85,"d":"1.00E-85"},"Heat shock protein beta-7",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.","GO:0007507|heart development;GO:0008016|regulation of heart contraction;GO:0006986|response to unfolded protein;","GO:0015629|actin cytoskeleton;GO:0016235|aggresome;GO:0015030|Cajal body;GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0031005|filamin binding;GO:0008022|protein C-terminus binding;","K09546","HSPB7; heat shock protein beta-7"]
["gene28034",1,1,6,2.43107071769141,88,254,138,175.920693066136,0.0138191288092383,-6.17718952210995,{"v":4.26748167686887e-06,"d":"4.27E-06"},0.000205668107639773,"down","yes","PKHD1","protein_coding","chrNC_037350.1:24074882-24512957:-","gi|529003375|ref|XP_002697357.2|",21084,0,"PREDICTED: fibrocystin [Bos taurus]","gi|983005221|ref|XM_015468904.1|",12598,0,"PREDICTED: Bos taurus polycystic kidney and hepatic disease 1 (autosomal recessive) (PKHD1), mRNA","P08F94",6430,0,"Fibrocystin",".",".",".",".","pfam10162","G8","G8 domain. This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.","GO:0098609|cell-cell adhesion;GO:0006874|cellular calcium ion homeostasis;GO:0060271|cilium morphogenesis;GO:0042592|homeostatic process;GO:0001822|kidney development;GO:0043066|negative regulation of apoptotic process;GO:0051271|negative regulation of cellular component movement;GO:0032088|negative regulation of NF-kappaB transcription factor activity;GO:0051898|negative regulation of protein kinase B signaling;GO:0008284|positive regulation of cell proliferation;GO:0010824|regulation of centrosome duplication;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0032006|regulation of TOR signaling;","GO:0031362|anchored component of external side of plasma membrane;GO:0016324|apical plasma membrane;GO:0005813|centrosome;GO:0000775|chromosome, centromeric region;GO:0036064|ciliary basal body;GO:0005929|cilium;GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0072686|mitotic spindle;GO:0048471|perinuclear region of cytoplasm;","GO:0038023|signaling receptor activity;",".","."]
["gene28045",126,102,120,103.120327153407,1152,542,976,981.797641415629,0.105032160196189,-3.25109695507653,{"v":6.00431541106807e-12,"d":"6.00E-12"},{"v":1.26895646661617e-09,"d":"1.27E-09"},"down","yes","PAQR8","protein_coding","chrNC_037350.1:24822987-24826624:+","gi|440905178|gb|ELR55596.1|",1879,0,"Membrane progestin receptor beta, partial [Bos mutus]","gi|155371996|ref|NM_001101135.1|",3638,0,"Bos taurus progestin and adipoQ receptor family member VIII (PAQR8), mRNA","Q865K9",656,0,"Membrane progestin receptor beta","SPBC12C2.09c",73.2,{"v":8e-13,"d":"8.00E-13"},"COG1272","pfam03006","HlyIII","Haemolysin-III related. Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolizm. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea.","GO:0007275|multicellular organismal development;GO:0048477|oogenesis;GO:0048545|response to steroid hormone;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005496|steroid binding;GO:0003707|steroid hormone receptor activity;",".","."]
["gene28104",172,298,193,201.761540425756,336,433,402,429.602796832754,0.469646710666789,-1.09035219006805,0.00134592250922573,0.0228846931529912,"down","yes","LOC107131209","protein_coding","chrNC_037350.1:27333700-27348351:-","gi|983005306|ref|XP_015324419.1|",8400,0,"PREDICTED: complement C4 isoform X2 [Bos taurus]","gi|156138946|gb|BC151618.1|",5216,0,"Bos taurus cDNA clone IMAGE:8409489, containing frame-shift errors","P0C0L4",2646,0,"Complement C4-A",".",".",".",".","pfam07678","A2M_comp","A-macroglobulin complement component. This family includes the complement components region of the alpha-2-macroglobulin family.","GO:0044267|cellular protein metabolic process;GO:0006956|complement activation;GO:0006958|complement activation, classical pathway;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:2000427|positive regulation of apoptotic cell clearance;GO:0043687|post-translational protein modification;GO:0030449|regulation of complement activation;","GO:0030424|axon;GO:0072562|blood microparticle;GO:0030054|cell junction;GO:0030425|dendrite;GO:0005788|endoplasmic reticulum lumen;GO:0070062|extracellular exosome;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0043025|neuronal cell body;GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0001849|complement component C1q binding;GO:0004866|endopeptidase inhibitor activity;GO:0004252|serine-type endopeptidase activity;","K03989","C4; complement component 4"]
["gene28114",75,68,73,64.2514242021555,147,239,173,205.102247948066,0.313265333973446,-1.67454296536892,0.000151399178112338,0.00410996189412286,"down","yes","C2","protein_coding","chrNC_037350.1:27421809-27433617:-","gi|529003594|ref|XP_005223711.1|",4228,0,"PREDICTED: complement C2 isoform X1 [Bos taurus]","gi|982963888|ref|XM_005223654.3|",2810,0,"PREDICTED: Bos taurus complement component 2 (C2), transcript variant X1, mRNA","Q3SYW2",1537,0,"Complement C2","mlr3307",55.1,{"v":5e-07,"d":"5.00E-07"},"COG5640","pfam00092","VWA","von Willebrand factor type A domain.","GO:0006958|complement activation, classical pathway;GO:0045087|innate immune response;","GO:0005576|extracellular region;","GO:0046872|metal ion binding;GO:0004252|serine-type endopeptidase activity;","K01332","C2; complement component 2 [EC:3.4.21.43]"]
["gene28230",196,105,136,127.261052907291,205,282,263,275.048822606127,0.462685321469382,-1.11189676425568,0.00375391846827517,0.0485948492823769,"down","yes","ZNRD1","protein_coding","chrNC_037350.1:28916743-28920655:-","gi|529003622|ref|XP_005223725.1|",687,{"v":9e-87,"d":"9.00E-87"},"PREDICTED: DNA-directed RNA polymerase I subunit RPA12 isoform X4 [Bos taurus]","gi|982963927|ref|XM_005223668.3|",1086,0,"PREDICTED: Bos taurus zinc ribbon domain containing 1 (ZNRD1), transcript variant X4, mRNA","Q1RMP0",250,{"v":3e-81,"d":"3.00E-81"},"DNA-directed RNA polymerase I subunit RPA12","YJR063w",75.1,{"v":2e-15,"d":"2.00E-15"},"COG1594","pfam01096","TFIIS_C","Transcription factor S-II (TFIIS).","GO:0006379|mRNA cleavage;GO:0006363|termination of RNA polymerase I transcription;","GO:0005736|DNA-directed RNA polymerase I complex;","GO:0003899|DNA-directed RNA polymerase activity;GO:0003676|nucleic acid binding;GO:0008270|zinc ion binding;","K03000","RPA12, ZNRD1; DNA-directed RNA polymerase I subunit RPA12"]
["gene2851",42,68,242,107.55441346633,685,454,588,634.895556508359,0.169404892448501,-2.56145255428297,{"v":6.48389996858769e-07,"d":"6.48E-07"},{"v":4.18776143243825e-05,"d":"4.19E-05"},"down","yes","UCK2","protein_coding","chrNC_037330.1:2984714-3058734:-","gi|300796464|ref|NP_001179741.1|",1385,0,"uridine-cytidine kinase 2 [Bos taurus]","gi|300796463|ref|NM_001192812.1|",1054,0,"Bos taurus uridine-cytidine kinase 2 (UCK2), mRNA","Q9QYG8",533,0,"Uridine-cytidine kinase 2","BH1275",192,{"v":4e-58,"d":"4.00E-58"},"COG0572","pfam00485","PRK","Phosphoribulokinase / Uridine kinase family. In Arabidopsis the region carries two binding domains, a phosphoribosylpyrophosphate-binding domain and, at the very C-terminus, a uracil-binding domain.","GO:0071453|cellular response to oxygen levels;GO:0006238|CMP salvage;GO:0044211|CTP salvage;GO:0007631|feeding behavior;GO:0016579|protein deubiquitination;GO:0006206|pyrimidine nucleobase metabolic process;GO:0043097|pyrimidine nucleoside salvage;GO:0048678|response to axon injury;GO:0044206|UMP salvage;","GO:0005829|cytosol;GO:0043231|intracellular membrane-bounded organelle;","GO:0005524|ATP binding;GO:0004849|uridine kinase activity;",".","."]
["gene28615",0,0,0,0,0,37,9,16.8272960486886,{"$error":"#NAME?"},{"$error":"#NAME?"},0.000526498820437403,0.0109566286257473,"down","yes","SLC17A1","protein_coding","chrNC_037350.1:32027267-32267361:+","gi|982964650|ref|XP_010816831.2|",2272,0,"PREDICTED: sodium-dependent phosphate transport protein 1 [Bos taurus]","gi|983005605|ref|XR_001499304.1|",1735,0,"PREDICTED: Bos taurus solute carrier family 17 (organic anion transporter), member 1 (SLC17A1), transcript variant X5, misc_RNA","Q28722",528,{"v":2e-171,"d":"2.00E-171"},"Sodium-dependent phosphate transport protein 1",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0006814|sodium ion transport;GO:0015747|urate transport;","GO:0016324|apical plasma membrane;GO:0016021|integral component of membrane;","GO:0015114|phosphate ion transmembrane transporter activity;GO:0015293|symporter activity;","K12300","SLC17A1S; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 1/2/3/4"]
["gene28809",737,548,298,463.190860568714,1576,830,1313,1367.61559493172,0.338684980110832,-1.56198408679782,0.000199010991643859,0.0050470956467475,"down","yes","F13A1","protein_coding","chrNC_037350.1:48770276-48913854:+","gi|268607679|ref|NP_001161366.1|",3932,0,"coagulation factor XIII A chain [Bos taurus]","gi|268607678|ref|NM_001167894.1|",3888,0,"Bos taurus coagulation factor XIII A chain (F13A1), mRNA","P00488",1365,0,"Coagulation factor XIII A chain",".",".",".",".","pfam00868","Transglut_N","Transglutaminase family.","GO:0007596|blood coagulation;GO:0072378|blood coagulation, fibrin clot formation;GO:0019221|cytokine-mediated signaling pathway;GO:0018149|peptide cross-linking;GO:0002576|platelet degranulation;","GO:0072562|blood microparticle;GO:0005576|extracellular region;GO:0031093|platelet alpha granule lumen;","GO:0046872|metal ion binding;GO:0003810|protein-glutamine gamma-glutamyltransferase activity;","K03917","F13A1; coagulation factor XIII A1 polypeptide [EC:2.3.2.13]"]
["gene28874",25,25,11,18.0868608707592,75,130,97,110.755360912458,0.163304608659577,-2.61436258876119,{"v":1.49338645626259e-05,"d":"1.49E-05"},0.000598424283477919,"down","yes","IRF4","protein_coding","chrNC_037350.1:52201695-52218938:-","gi|329663890|ref|NP_001193091.1|",2426,0,"interferon regulatory factor 4 [Bos taurus]","gi|982964701|ref|XM_005223855.3|",4756,0,"PREDICTED: Bos taurus interferon regulatory factor 4 (IRF4), transcript variant X1, mRNA","Q15306",873,0,"Interferon regulatory factor 4",".",".",".",".","pfam10401","IRF-3","Interferon-regulatory factor 3. This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1).  Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.","GO:0019221|cytokine-mediated signaling pathway;GO:0042832|defense response to protozoan;GO:0043966|histone H3 acetylation;GO:0043967|histone H4 acetylation;GO:0060333|interferon-gamma-mediated signaling pathway;GO:0043011|myeloid dendritic cell differentiation;GO:0034122|negative regulation of toll-like receptor signaling pathway;GO:0043388|positive regulation of DNA binding;GO:0045082|positive regulation of interleukin-10 biosynthetic process;GO:0045368|positive regulation of interleukin-13 biosynthetic process;GO:0045086|positive regulation of interleukin-2 biosynthetic process;GO:0045404|positive regulation of interleukin-4 biosynthetic process;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0045622|regulation of T-helper cell differentiation;GO:0042110|T cell activation;GO:0072540|T-helper 17 cell lineage commitment;GO:0060337|type I interferon signaling pathway;","GO:0005829|cytosol;GO:0016020|membrane;GO:0000788|nuclear nucleosome;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0016279|protein-lysine N-methyltransferase activity;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09445","IRF4; interferon regulatory factor 4"]
["gene28945",15,3,1,5.19962322377105,49,59,50,58.0155474120986,0.0896246515927335,-3.47996058428835,0.000863104659878934,0.0161513844735183,"down","yes","CBLN2","protein_coding","chrNC_037351.1:5330841-5339281:+","gi|440892799|gb|ELR45838.1|",932,{"v":3e-114,"d":"3.00E-114"},"Cerebellin-2, partial [Bos mutus]","gi|982965104|ref|XM_015460042.1|",3468,0,"PREDICTED: Bos taurus cerebellin 2 precursor (CBLN2), transcript variant X1, mRNA","Q8IUK8",362,{"v":1e-114,"d":"1.00E-114"},"Cerebellin-2",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0051965|positive regulation of synapse assembly;","GO:0005615|extracellular space;",".",".","."]
["gene28995",3767,4080,4441,3682.78303917848,7809,6114,7191,7758.27305392248,0.474691083129191,-1.07493914528037,0.000369933151477932,0.00831067932662746,"down","yes","FHOD3","protein_coding","chrNC_037351.1:20334461-20858181:-","gi|529004727|ref|XP_005224099.1|",6355,0,"PREDICTED: FH1/FH2 domain-containing protein 3 isoform X1 [Bos taurus]","gi|982965257|ref|XM_005224042.2|",7188,0,"PREDICTED: Bos taurus formin homology 2 domain containing 3 (FHOD3), transcript variant X1, mRNA","Q2V2M9",1451,0,"FH1/FH2 domain-containing protein 3",".",".",".",".","pfam02181","FH2","Formin Homology 2 Domain.","GO:0051639|actin filament network formation;GO:0055003|cardiac myofibril assembly;GO:0030837|negative regulation of actin filament polymerization;GO:0045214|sarcomere organization;","GO:0005865|striated muscle thin filament;GO:0030018|Z disc;","GO:0003779|actin binding;",".","."]
["gene2903",16,4,0,5.48084250620575,89,47,66,74.3379864068725,0.0737286920338085,-3.7616300263636,0.000338460431242846,0.00771295092954444,"down","yes","FCGR2A","protein_coding","chrNC_037330.1:8035866-8044881:-","gi|741919197|ref|XP_010801084.1|",1745,0,"PREDICTED: low affinity immunoglobulin gamma Fc region receptor II-a isoform X6 [Bos taurus]","gi|982916071|ref|XR_001495548.1|",1986,0,"PREDICTED: Bos taurus Fc fragment of IgG receptor IIa (FCGR2A), transcript variant X8, misc_RNA","Q28110",432,{"v":2e-140,"d":"2.00E-140"},"Low affinity immunoglobulin gamma Fc region receptor II",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.",".","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0019864|IgG binding;","K12560","FCGR2B, CD32; low affinity immunoglobulin gamma Fc region receptor II-b"]
["gene29051",34,32,42,32.2472643985824,1210,147,803,796.067791193111,0.0405081888192607,-4.62564260832689,{"v":1.18654785607754e-16,"d":"1.19E-16"},{"v":5.20821490488436e-14,"d":"5.21E-14"},"down","yes","CDH2","protein_coding","chrNC_037351.1:28655756-28904115:+","gi|262063570|ref|NP_001159964.1|",4226,0,"cadherin-2 [Bos taurus]","gi|262063569|ref|NM_001166492.1|",4312,0,"Bos taurus cadherin 2, type 1, N-cadherin (neuronal) (CDH2), mRNA","P19534",1599,0,"Cadherin-2 (Fragment)",".",".",".",".","pfam08758","Cadherin_pro","Cadherin prodomain like. Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.","GO:0044331|cell-cell adhesion mediated by cadherin;GO:0010001|glial cell differentiation;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0097150|neuronal stem cell population maintenance;GO:0009966|regulation of signal transduction;","GO:0030054|cell junction;GO:0009986|cell surface;GO:0016021|integral component of membrane;GO:0014704|intercalated disc;GO:0005886|plasma membrane;GO:0042383|sarcolemma;","GO:0005509|calcium ion binding;",".","."]
["gene29075",195,195,283,201.641900939439,675,348,506,562.657416440464,0.358374199019867,-1.48046131989692,0.000829387337662118,0.0156918104315901,"down","yes","TTC39C","protein_coding","chrNC_037351.1:32558046-32662991:-","gi|529004909|ref|XP_003587817.2|",2977,0,"PREDICTED: tetratricopeptide repeat protein 39C isoform X1 [Bos taurus]","gi|742224466|ref|XM_010828925.1|",3864,0,"PREDICTED: Bison bison bison tetratricopeptide repeat domain 39C (TTC39C), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam10300","DUF3808","Protein of unknown function (DUF3808). This is a family of proteins conserved from fungi to humans. Members of this family also carry a TPR_2 domain pfam07719 at their C-terminus.",".",".",".",".","."]
["gene29099",158,92,206,134.595554430397,393,224,371,363.017016512448,0.370769270607406,-1.43140641667208,0.00101375626503489,0.0182367465307127,"down","yes","ABHD3","protein_coding","chrNC_037351.1:34541436-34591101:+","gi|115495965|ref|NP_001069655.1|",2031,0,"phospholipase ABHD3 [Bos taurus]","gi|115495964|ref|NM_001076187.1|",1916,0,"Bos taurus abhydrolase domain containing 3 (ABHD3), mRNA","Q0VC00",786,0,"Phospholipase ABHD3","PA0368",133,{"v":3e-33,"d":"3.00E-33"},"COG0429","pfam00561","Abhydrolase_1","alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes.","GO:0046470|phosphatidylcholine metabolic process;","GO:0016021|integral component of membrane;","GO:0052740|1-acyl-2-lysophosphatidylserine acylhydrolase activity;GO:0008970|phosphatidylcholine 1-acylhydrolase activity;GO:0052739|phosphatidylserine 1-acylhydrolase activity;GO:0004623|phospholipase A2 activity;","K13696","ABHD1_3; abhydrolase domain-containing protein 1/3"]
["gene29138",30480,23097,47025,29955.4863158234,101263,79436,101227,103541.105226094,0.289310088494923,-1.78931146270928,0.00113076550536443,0.0198412488521233,"down","yes","MYL12A","protein_coding","chrNC_037351.1:37403043-37413273:+","gi|521027489|gb|EPQ09277.1|",814,{"v":2e-102,"d":"2.00E-102"},"Myosin regulatory light polypeptide 9 [Myotis brandtii]","gi|110347587|ref|NM_001015640.2|",1554,0,"Bos taurus myosin, light chain 12A, regulatory, non-sarcomeric (MYL12A), mRNA","Q5E9E2",315,{"v":1e-103,"d":"1.00E-103"},"Myosin regulatory light polypeptide 9","ECU03g1570",111,{"v":1e-27,"d":"1.00E-27"},"COG5126","pfam13405","EF-hand_6","EF-hand domain.","GO:0031032|actomyosin structure organization;","GO:0042641|actomyosin;GO:0016460|myosin II complex;GO:0097513|myosin II filament;","GO:0016887|ATPase activity;GO:0005509|calcium ion binding;","K12757","MYL12; myosin regulatory light chain 12"]
["gene29141",359,192,454,295.918758089944,848,494,654,734.323468605987,0.402981479880665,-1.31121455761868,0.00159470511334654,0.0261185600395466,"down","yes","TGIF1","protein_coding","chrNC_037351.1:37498883-37535210:+","gi|741972612|ref|XP_010817124.1|",1295,{"v":4e-160,"d":"4.00E-160"},"PREDICTED: homeobox protein TGIF1 isoform X1 [Bos taurus]","gi|850494308|gb|CP011908.1|",3353,0,"Ovis canadensis canadensis isolate 43U chromosome 23 sequence","Q15583",431,{"v":4e-134,"d":"4.00E-134"},"Homeobox protein TGIF1",".",".",".",".","pfam05920","Homeobox_KN","Homeobox KN domain. This is a homeobox transcription factor KN domain conserved from fungi to human and plants.","GO:0071363|cellular response to growth factor stimulus;GO:0007275|multicellular organismal development;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0042493|response to drug;GO:0006351|transcription, DNA-templated;","GO:0005654|nucleoplasm;","GO:0070410|co-SMAD binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0003714|transcription corepressor activity;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K19383","TGIF1; homeobox protein TGIF1"]
["gene29193",217,78,386,200.666171944299,1023,666,925,960.678399025355,0.208879654364959,-2.25925611936243,{"v":2.45743942382274e-06,"d":"2.46E-06"},0.000129360155352558,"down","yes","IMPA2","protein_coding","chrNC_037351.1:42749323-42770783:+","gi|300796091|ref|NP_001179211.1|",1454,0,"inositol monophosphatase 2 [Bos taurus]","gi|300796090|ref|NM_001192282.1|",1450,0,"Bos taurus inositol(myo)-1(or 4)-monophosphatase 2 (IMPA2), mRNA","O14732",518,0,"Inositol monophosphatase 2","PM0315",147,{"v":2e-39,"d":"2.00E-39"},"COG0483","pfam00459","Inositol_P","Inositol monophosphatase family.","GO:0006021|inositol biosynthetic process;GO:0006020|inositol metabolic process;GO:0046855|inositol phosphate dephosphorylation;GO:0043647|inositol phosphate metabolic process;GO:0006796|phosphate-containing compound metabolic process;GO:0046854|phosphatidylinositol phosphorylation;GO:0007165|signal transduction;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0008934|inositol monophosphate 1-phosphatase activity;GO:0052832|inositol monophosphate 3-phosphatase activity;GO:0052833|inositol monophosphate 4-phosphatase activity;GO:0046872|metal ion binding;GO:0042803|protein homodimerization activity;","K01092","E3.1.3.25, IMPA, suhB; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]"]
["gene29194",35,41,59,40.6784145196157,123,120,127,135.855540205036,0.299424038638564,-1.73973804505921,0.000523510999152186,0.0109263294197593,"down","yes","CIDEA","protein_coding","chrNC_037351.1:42778433-42792110:+","gi|742198894|ref|XP_010857369.1|",719,{"v":5e-135,"d":"5.00E-135"},"PREDICTED: cell death activator CIDE-A isoform X1 [Bison bison bison]","gi|983006391|ref|XM_015469154.1|",2415,0,"PREDICTED: Bos taurus cell death-inducing DFFA-like effector a (CIDEA), mRNA","O70302",177,{"v":2e-80,"d":"2.00E-80"},"Cell death activator CIDE-A",".",".",".",".","pfam02017","CIDE-N","CIDE-N domain. This domain is found in CAD nuclease, and in ICAD, the inhibitor of CAD nuclease. The two proteins interact through this domain.","GO:0006915|apoptotic process;GO:0008219|cell death;GO:0006629|lipid metabolic process;GO:0019915|lipid storage;GO:0050710|negative regulation of cytokine secretion;GO:1900118|negative regulation of execution phase of apoptosis;GO:0050995|negative regulation of lipid catabolic process;GO:0030512|negative regulation of transforming growth factor beta receptor signaling pathway;GO:0032720|negative regulation of tumor necrosis factor production;GO:0010890|positive regulation of sequestering of triglyceride;GO:1902510|regulation of apoptotic DNA fragmentation;GO:0006355|regulation of transcription, DNA-templated;GO:0035634|response to stilbenoid;GO:0001659|temperature homeostasis;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005811|lipid particle;GO:0005740|mitochondrial envelope;GO:0005739|mitochondrion;GO:0005634|nucleus;","GO:0042803|protein homodimerization activity;",".","."]
["gene29426",592,1264,1166,926.627927511216,3385,1300,2852,2771.78350283076,0.334307469023057,-1.58075250720051,0.00267772298471836,0.0380468697594619,"down","yes","RAB11FIP3","protein_coding","chrNC_037352.1:405324-465303:+","gi|359079536|ref|XP_003587853.1|",3347,0,"PREDICTED: rab11 family-interacting protein 3 isoform X1 [Bos taurus]","gi|983006679|ref|XM_001256127.6|",3227,0,"PREDICTED: Bos taurus RAB11 family interacting protein 3 (class II) (RAB11FIP3), transcript variant X1, mRNA","O75154",1016,0,"Rab11 family-interacting protein 3",".",".",".",".","pfam01576","Myosin_tail_1","Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.","GO:0000910|cytokinesis;GO:0032456|endocytic recycling;GO:0070164|negative regulation of adiponectin secretion;GO:0032465|regulation of cytokinesis;GO:0016192|vesicle-mediated transport;","GO:0005813|centrosome;GO:0032154|cleavage furrow;GO:0005829|cytosol;GO:0005768|endosome;GO:0045171|intercellular bridge;GO:0043231|intracellular membrane-bounded organelle;GO:0005815|microtubule organizing center;GO:0030496|midbody;GO:0005654|nucleoplasm;GO:0055037|recycling endosome;GO:0055038|recycling endosome membrane;","GO:0030306|ADP-ribosylation factor binding;GO:0005509|calcium ion binding;GO:0051959|dynein light intermediate chain binding;GO:0042803|protein homodimerization activity;GO:0017137|Rab GTPase binding;","K12485","RAB11FIP3_4; Rab11 family-interacting protein 3/4"]
["gene29808",0,0,0,0,0,313,108,153.852181046646,{"$error":"#NAME?"},{"$error":"#NAME?"},{"v":1.58141416557383e-15,"d":"1.58E-15"},{"v":6.09720642675499e-13,"d":"6.10E-13"},"down","yes","UMOD","protein_coding","chrNC_037352.1:18009949-18028531:-","gi|296473384|tpg|DAA15499.1|",3246,0,"TPA: uromodulin precursor [Bos taurus]","gi|942053993|ref|XM_005895574.2|",2316,0,"PREDICTED: Bos mutus uromodulin (UMOD), transcript variant X1, mRNA","P48733",1255,0,"Uromodulin",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.",".","GO:0031225|anchored component of membrane;GO:0016324|apical plasma membrane;GO:0016323|basolateral plasma membrane;GO:0060170|ciliary membrane;GO:0005929|cilium;GO:0005576|extracellular region;GO:0000922|spindle pole;","GO:0005509|calcium ion binding;","K18274","UMOD; uromodulin"]
["gene29811",0,1,0,0.327717679206592,6,33,8,17.2409814253869,0.0190080640493026,-5.71724458723049,0.00139602958935186,0.0235480359607849,"down","yes","ACSM2B","protein_coding","chrNC_037352.1:18130586-18210919:+","gi|156120553|ref|NP_001095422.1|",2936,0,"acyl-CoA synthetase medium-chain family member 2B [Bos taurus]","gi|942053996|ref|XM_005895572.2|",2705,0,"PREDICTED: Bos mutus acyl-coenzyme A synthetase ACSM2B, mitochondrial (LOC102271620), mRNA","Q68CK6",914,0,"Acyl-coenzyme A synthetase ACSM2B, mitochondrial","MA2912",329,{"v":1e-99,"d":"1.00E-99"},"COG0365","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0006637|acyl-CoA metabolic process;GO:0006633|fatty acid biosynthetic process;GO:0006805|xenobiotic metabolic process;","GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0003996|acyl-CoA ligase activity;GO:0005524|ATP binding;GO:0047760|butyrate-CoA ligase activity;GO:0016405|CoA-ligase activity;GO:0015645|fatty acid ligase activity;GO:0004321|fatty-acyl-CoA synthase activity;GO:0046872|metal ion binding;","K01896","ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]"]
["gene29812",8,75,116,62.2899213337239,1026,741,960,1001.95782206598,0.0621682070461665,-4.00767921815213,{"v":1.88408955300078e-12,"d":"1.88E-12"},{"v":4.4795799197221e-10,"d":"4.48E-10"},"down","yes","ACSM1","protein_coding","chrNC_037352.1:18233709-18298234:+","gi|529006474|ref|XP_005224748.1|",3115,0,"PREDICTED: acyl-coenzyme A synthetase ACSM1, mitochondrial isoform X1 [Bos taurus]","gi|742106420|ref|XM_010837142.1|",2284,0,"PREDICTED: Bison bison bison acyl-CoA synthetase medium-chain family member 1 (ACSM1), transcript variant X1, mRNA","Q9BEA2",1199,0,"Acyl-coenzyme A synthetase ACSM1, mitochondrial","MA2912",380,{"v":7e-121,"d":"7.00E-121"},"COG0365","pfam00501","AMP-binding","AMP-binding enzyme.","GO:0006637|acyl-CoA metabolic process;GO:0006633|fatty acid biosynthetic process;","GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0003996|acyl-CoA ligase activity;GO:0005524|ATP binding;GO:0047760|butyrate-CoA ligase activity;GO:0015645|fatty acid ligase activity;GO:0004321|fatty-acyl-CoA synthase activity;GO:0005525|GTP binding;GO:0046872|metal ion binding;","K01896","ACSM; medium-chain acyl-CoA synthetase [EC:6.2.1.2]"]
["gene29828",470,592,1384,741.558128316934,5393,3264,4712,4914.4829859403,0.150892399147262,-2.7284079595909,{"v":6.10769623081481e-07,"d":"6.11E-07"},{"v":4.0244499113482e-05,"d":"4.02E-05"},"down","yes","TMEM159","protein_coding","chrNC_037352.1:18976394-18992770:+","gi|122692351|ref|NP_001073830.1|",345,{"v":6e-36,"d":"6.00E-36"},"promethin [Bos taurus]","gi|122692350|ref|NM_001080361.1|",1346,0,"Bos taurus transmembrane protein 159 (TMEM159), mRNA","Q96B96",86.3,{"v":3e-18,"d":"3.00E-18"},"Promethin",".",".",".",".","pfam03252","Herpes_UL21","Herpesvirus UL21. The UL21 protein appears to be a dispensable component in herpesviruses.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene30014",55,7,31,26.1490724222889,65,100,91,93.8422156102069,0.27864935042566,-1.84347730461066,0.00310436462143863,0.0423361319133431,"down","yes","ITGAX","protein_coding","chrNC_037352.1:27398392-27419163:+","gi|742107582|ref|XP_010835674.1|",6068,0,"PREDICTED: integrin alpha-X [Bison bison bison]","gi|742107581|ref|XM_010837372.1|",4941,0,"PREDICTED: Bison bison bison integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), mRNA","P20702",1666,0,"Integrin alpha-X",".",".",".",".","pfam08441","Integrin_alpha2","Integrin alpha. This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.","GO:0009887|organ morphogenesis;GO:0007155|cell adhesion;GO:0019221|cytokine-mediated signaling pathway;GO:0030198|extracellular matrix organization;GO:0034113|heterotypic cell-cell adhesion;GO:0007229|integrin-mediated signaling pathway;GO:0050900|leukocyte migration;GO:0043312|neutrophil degranulation;","GO:0009986|cell surface;GO:0008305|integrin complex;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0030667|secretory granule membrane;GO:0070821|tertiary granule membrane;","GO:0046872|metal ion binding;GO:0038023|signaling receptor activity;","K06462","ITGAX; integrin alpha X"]
["gene30124",710,454,774,571.538468926174,901,2224,1461,1680.32679271929,0.340135306657371,-1.55581932672532,0.000375177004345737,0.0084086214540363,"down","yes","TMEM120A","protein_coding","chrNC_037352.1:34213531-34219037:-","gi|58219512|ref|NP_001010945.1|",1543,0,"transmembrane protein 120A [Rattus norvegicus]","gi|118601795|ref|NM_001079600.1|",1302,0,"Bos taurus transmembrane protein 120A (TMEM120A), mRNA","Q5HZE2",598,0,"Transmembrane protein 120A",".",".",".",".","pfam07851","TMPIT","TMPIT-like protein. A number of members of this family are annotated as being transmembrane proteins induced by tumor necrosis factor alpha, but no literature was found to support this.","GO:0045444|fat cell differentiation;GO:0051291|protein heterooligomerization;GO:0051260|protein homooligomerization;","GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005637|nuclear inner membrane;",".",".","."]
["gene30501",3620,6789,14081,7492.91116431632,139239,22373,93645,94057.0141294577,0.079663502330653,-3.64993728195321,{"v":6.25066609539743e-05,"d":"6.25E-05"},0.00196924288738923,"down","yes","ANKRD1","protein_coding","chrNC_037353.1:12533108-12542479:-","gi|77735703|ref|NP_001029550.1|",1502,0,"ankyrin repeat domain-containing protein 1 [Bos taurus]","gi|402766900|ref|NM_001034378.2|",1751,0,"Bos taurus ankyrin repeat domain 1 (cardiac muscle) (ANKRD1), mRNA","Q3ZBX7",583,0,"Ankyrin repeat domain-containing protein 1","TVN1399",84.3,{"v":1e-17,"d":"1.00E-17"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0055008|cardiac muscle tissue morphogenesis;GO:0035690|cellular response to drug;GO:0071347|cellular response to interleukin-1;GO:0071222|cellular response to lipopolysaccharide;GO:0071260|cellular response to mechanical stimulus;GO:0071560|cellular response to transforming growth factor beta stimulus;GO:0071356|cellular response to tumor necrosis factor;GO:0045445|myoblast differentiation;GO:2000279|negative regulation of DNA biosynthetic process;GO:0043065|positive regulation of apoptotic process;GO:0043517|positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0050714|positive regulation of protein secretion;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0035994|response to muscle stretch;GO:0035914|skeletal muscle cell differentiation;","GO:0005829|cytosol;GO:0001650|fibrillar center;GO:0031674|I band;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003677|DNA binding;GO:0042826|histone deacetylase binding;GO:0002039|p53 binding;GO:0070412|R-SMAD binding;GO:0061629|RNA polymerase II sequence-specific DNA binding transcription factor binding;GO:0001105|RNA polymerase II transcription coactivator activity;GO:0031432|titin binding;GO:0003712|transcription cofactor activity;GO:0003714|transcription corepressor activity;",".","."]
["gene30518",1389,984,1369,1104.92938871428,3620,2030,2842,3123.91020050197,0.353700752517384,-1.49939880643393,0.000108757173674077,0.00309497767639013,"down","yes","EXOC6","protein_coding","chrNC_037353.1:14211740-14401745:+","gi|741975832|ref|XP_010818144.1|",4031,0,"PREDICTED: exocyst complex component 6 isoform X1 [Bos taurus]","gi|982968019|ref|XM_005225489.3|",3478,0,"PREDICTED: Bos taurus exocyst complex component 6 (EXOC6), transcript variant X4, mRNA","E2R766",1480,0,"Exocyst complex component 6",".",".",".",".","pfam04091","Sec15","Exocyst complex subunit Sec15-like.","GO:0015031|protein transport;GO:0006904|vesicle docking involved in exocytosis;","GO:0000145|exocyst;GO:0090543|Flemming body;GO:0030426|growth cone;GO:0048471|perinuclear region of cytoplasm;",".",".","."]
["gene30525",200,403,665,388.430758436886,1471,1344,1594,1618.43493757824,0.240003938013175,-2.05887001694744,{"v":4.11237509984055e-08,"d":"4.11E-08"},{"v":3.80942123290749e-06,"d":"3.81E-06"},"down","yes","RBP4","protein_coding","chrNC_037353.1:14896203-14902792:-","gi|164420709|ref|NP_001035565.2|",1019,{"v":1e-135,"d":"1.00E-135"},"retinol-binding protein 4 precursor [Bos taurus]","gi|741975694|ref|XM_010819784.1|",911,0,"PREDICTED: Bos taurus retinol binding protein 4 (RBP4), transcript variant X1, mRNA","P18902",388,{"v":7e-134,"d":"7.00E-134"},"Retinol-binding protein 4",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.",".","GO:0005615|extracellular space;","GO:0016918|retinal binding;GO:0019841|retinol binding;GO:0034632|retinol transporter activity;",".","."]
["gene30567",7970,2352,7348,5104.68894283084,10506,8694,10403,10872.5984388557,0.469500365670461,-1.09080181336453,0.00164109511670808,0.0266337228525588,"down","yes","PDLIM1","protein_coding","chrNC_037353.1:16743890-16784516:-","gi|555973787|ref|XP_005898889.1|",1680,0,"PREDICTED: PDZ and LIM domain protein 1 [Bos mutus]","gi|148877478|gb|BC146213.1|",1438,0,"Bos taurus PDZ and LIM domain 1, mRNA (cDNA clone MGC:166382 IMAGE:8474203), complete cds","Q5E9E1",651,0,"PDZ and LIM domain protein 1",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0006355|regulation of transcription, DNA-templated;","GO:0005856|cytoskeleton;GO:0005667|transcription factor complex;GO:0030018|Z disc;","GO:0046872|metal ion binding;GO:0003713|transcription coactivator activity;",".","."]
["gene306",522,404,506,423.846818633665,3733,1114,2686,2773.67361089982,0.152810632429157,-2.71018316657158,{"v":2.25569872300257e-09,"d":"2.26E-09"},{"v":2.71549958928212e-07,"d":"2.72E-07"},"down","yes","ALCAM","protein_coding","chrNC_037328.1:49930779-50162053:+","gi|528936216|ref|XP_005201313.1|",2923,0,"PREDICTED: CD166 antigen isoform X1 [Bos taurus]","gi|982909957|ref|XM_005201256.3|",4890,0,"PREDICTED: Bos taurus activated leukocyte cell adhesion molecule (ALCAM), transcript variant X1, mRNA","Q9BH13",1128,0,"CD166 antigen",".",".",".",".","pfam08205","C2-set_2","CD80-like C2-set immunoglobulin domain. These domains belong to the immunoglobulin superfamily.","GO:0002250|adaptive immune response;GO:0048846|axon extension involved in axon guidance;GO:0007155|cell adhesion;GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:1990138|neuron projection extension;GO:0031290|retinal ganglion cell axon guidance;","GO:0030424|axon;GO:0030425|dendrite;GO:0001772|immunological synapse;GO:0005887|integral component of plasma membrane;GO:0031226|intrinsic component of plasma membrane;",".","K06547","ALCAM; activated leukocyte cell adhesion molecule"]
["gene30602",1227,1409,5502,2471.3221497119,48975,36770,47280,48866.2232946158,0.0505732177175271,-4.30548261701574,{"v":6.1167723979717e-09,"d":"6.12E-09"},{"v":6.66097836971491e-07,"d":"6.66E-07"},"down","yes","ANKRD2","protein_coding","chrNC_037353.1:18762356-18771322:+","gi|555978586|ref|XP_005901231.1|",1613,0,"PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat domain-containing protein 2 [Bos mutus]","gi|983007777|ref|XM_003584085.4|",1270,0,"PREDICTED: Bos taurus ankyrin repeat domain 2 (stretch responsive muscle) (ANKRD2), mRNA","Q9GZV1",551,0,"Ankyrin repeat domain-containing protein 2","all2748",94.7,{"v":2e-20,"d":"2.00E-20"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).","GO:0006936|muscle contraction;GO:0007517|muscle organ development;GO:0045662|negative regulation of myoblast differentiation;GO:0010832|negative regulation of myotube differentiation;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0001817|regulation of cytokine production;GO:1902253|regulation of intrinsic apoptotic signaling pathway by p53 class mediator;GO:2000291|regulation of myoblast proliferation;GO:0043619|regulation of transcription from RNA polymerase II promoter in response to oxidative stress;GO:0035914|skeletal muscle cell differentiation;","GO:0005829|cytosol;GO:0000791|euchromatin;GO:0031674|I band;GO:0043231|intracellular membrane-bounded organelle;GO:0005634|nucleus;GO:0016605|PML body;","GO:0003682|chromatin binding;GO:0043422|protein kinase B binding;GO:0061629|RNA polymerase II sequence-specific DNA binding transcription factor binding;GO:0008307|structural constituent of muscle;GO:0031432|titin binding;GO:0003712|transcription cofactor activity;",".","."]
["gene30603",36,10,47,27.0943300977503,124,71,144,124.383456518443,0.217829049426141,-2.19873173188666,0.000312704995434589,0.00724759238403271,"down","yes","HOGA1","protein_coding","chrNC_037353.1:18771696-18793851:+","gi|122145339|sp|Q0P5I5.1|HOGA1_BOVIN",1558,0,"RecName: Full=4-hydroxy-2-oxoglutarate aldolase, mitochondrial; AltName: Full=Dihydrodipicolinate synthase-like; Short=DHDPS-like protein; AltName: Full=Probable 2-keto-4-hydroxyglutarate aldolase; Short=Probable KHG-aldolase; Flags: Precursor","gi|742089304|ref|XM_010833066.1|",2131,0,"PREDICTED: Bison bison bison 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), mRNA","Q0P5I5",604,0,"4-hydroxy-2-oxoglutarate aldolase, mitochondrial","VNG0444G",131,{"v":1e-32,"d":"1.00E-32"},"COG0329","pfam00701","DHDPS","Dihydrodipicolinate synthetase family. This family has a TIM barrel structure.","GO:0019470|4-hydroxyproline catabolic process;GO:0009436|glyoxylate catabolic process;GO:0033609|oxalate metabolic process;GO:0042866|pyruvate biosynthetic process;","GO:0005739|mitochondrion;","GO:0008700|4-hydroxy-2-oxoglutarate aldolase activity;GO:0042803|protein homodimerization activity;","K18123","HOGA1; 4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16]"]
["gene30611",21,153,135,97.0753134292627,497,258,468,449.380845417281,0.216020140642891,-2.21076226652166,0.000533083544250119,0.0110533478204943,"down","yes","SFRP5","protein_coding","chrNC_037353.1:18914372-18919213:-","gi|27806141|ref|NP_776886.1|",1427,0,"secreted frizzled-related protein 5 precursor [Bos taurus]","gi|151554144|gb|BC149165.1|",1716,0,"Bos taurus secreted frizzled-related protein 5, mRNA (cDNA clone MGC:155128 IMAGE:8481826), complete cds","Q9XSC1",554,0,"Secreted frizzled-related protein 5",".",".",".",".","pfam01392","Fz","Fz domain. Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups. The domain contains 10 conserved cysteines.","GO:0060070|canonical Wnt signaling pathway;GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0090090|negative regulation of canonical Wnt signaling pathway;GO:0008285|negative regulation of cell proliferation;GO:0043433|negative regulation of sequence-specific DNA binding transcription factor activity;GO:0051898|negative regulation of protein kinase B signaling;GO:0030178|negative regulation of Wnt signaling pathway;GO:2000057|negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis;GO:0035567|non-canonical Wnt signaling pathway;GO:0030510|regulation of BMP signaling pathway;","GO:0005576|extracellular region;GO:0016021|integral component of membrane;","GO:0004930|G-protein coupled receptor activity;GO:0042813|Wnt-activated receptor activity;GO:0017147|Wnt-protein binding;","K02222","SFRP5; secreted frizzled-related protein 5"]
["gene30614",10,20,27,17.4528700599127,128,54,105,105.561797556686,0.165333202577766,-2.59655161596703,0.000118635968038614,0.00334120264462988,"down","yes","CRTAC1","protein_coding","chrNC_037353.1:19019143-19170819:-","gi|965997928|ref|XP_014958849.1|",3020,0,"PREDICTED: cartilage acidic protein 1 isoform X2 [Ovis aries]","gi|328927043|ref|NM_001205325.1|",2234,0,"Bos taurus cartilage acidic protein 1 (CRTAC1), transcript variant 2, mRNA","Q9NQ79",1118,0,"Cartilage acidic protein 1",".",".",".",".","pfam07645","EGF_CA","Calcium-binding EGF domain.","GO:0007413|axonal fasciculation;GO:1900121|negative regulation of receptor binding;GO:0021772|olfactory bulb development;","GO:0070062|extracellular exosome;GO:0030426|growth cone;","GO:0005509|calcium ion binding;",".","."]
["gene30656",0,0,0,0,0,51,14,23.769986456807,{"$error":"#NAME?"},{"$error":"#NAME?"},{"v":6.66760977623442e-05,"d":"6.67E-05"},0.00207000625164031,"down","yes","PAX2","protein_coding","chrNC_037353.1:21589730-21679960:+","gi|982968332|ref|XP_015316206.1|",2109,0,"PREDICTED: paired box protein Pax-2 isoform X12 [Bos taurus]","gi|983007848|ref|XM_015469575.1|",5950,0,"PREDICTED: Bos taurus paired box 2 (PAX2), transcript variant X16, mRNA","Q02962",736,0,"Paired box protein Pax-2",".",".",".",".","pfam00292","PAX","'Paired box' domain.","GO:0007568|aging;GO:0007409|axonogenesis;GO:0048854|brain morphogenesis;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0043010|camera-type eye development;GO:0001709|cell fate determination;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071333|cellular response to glucose stimulus;GO:0070301|cellular response to hydrogen peroxide;GO:0071300|cellular response to retinoic acid;GO:0090102|cochlea development;GO:0090103|cochlea morphogenesis;GO:0010001|glial cell differentiation;GO:0042472|inner ear morphogenesis;GO:0060231|mesenchymal to epithelial transition;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0007501|mesodermal cell fate specification;GO:0001823|mesonephros development;GO:0072205|metanephric collecting duct development;GO:0072221|metanephric distal convoluted tubule development;GO:0072207|metanephric epithelium development;GO:0072162|metanephric mesenchymal cell differentiation;GO:0072075|metanephric mesenchyme development;GO:0072289|metanephric nephron tubule formation;GO:0043066|negative regulation of apoptotic process;GO:1900215|negative regulation of apoptotic process involved in metanephric collecting duct development;GO:1900218|negative regulation of apoptotic process involved in metanephric nephron tubule development;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045918|negative regulation of cytolysis;GO:0072305|negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis;GO:1900212|negative regulation of mesenchymal cell apoptotic process involved in metanephros development;GO:0043069|negative regulation of programmed cell death;GO:2000378|negative regulation of reactive oxygen species metabolic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0072179|nephric duct formation;GO:0001843|neural tube closure;GO:0061360|optic chiasma development;GO:0002072|optic cup morphogenesis involved in camera-type eye development;GO:0021554|optic nerve development;GO:0021631|optic nerve morphogenesis;GO:0021633|optic nerve structural organization;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0072108|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:2000594|positive regulation of metanephric DCT cell differentiation;GO:0072300|positive regulation of metanephric glomerulus development;GO:2000597|positive regulation of optic nerve formation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0039003|pronephric field specification;GO:0048793|pronephros development;GO:0043491|protein kinase B signaling;GO:0072593|reactive oxygen species metabolic process;GO:0072307|regulation of metanephric nephron tubule epithelial cell differentiation;GO:0035566|regulation of metanephros size;GO:0031667|response to nutrient levels;GO:0003406|retinal pigment epithelium development;GO:0048863|stem cell differentiation;GO:0006366|transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;GO:0072189|ureter development;GO:0035799|ureter maturation;GO:0001655|urogenital system development;GO:0021650|vestibulocochlear nerve formation;GO:0007601|visual perception;","GO:0034451|centriolar satellite;GO:0005794|Golgi apparatus;GO:0005764|lysosome;GO:0005815|microtubule organizing center;GO:0005730|nucleolus;GO:0005634|nucleus;GO:0032991|macromolecular complex;GO:0032993|protein-DNA complex;","GO:0003677|DNA binding;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0008134|transcription factor binding;GO:0044212|transcription regulatory region DNA binding;","K15608","PAX2; paired box protein 2"]
["gene30716",2356,986,2073,1573.82112415341,7845,3302,5697,6200.46616582168,0.253823032343705,-1.9781051071095,{"v":8.33810951042632e-06,"d":"8.34E-06"},0.000372292022600897,"down","yes","NT5C2","protein_coding","chrNC_037353.1:23739161-23836700:-","gi|686734359|ref|XP_009244020.1|",1989,0,"PREDICTED: cytosolic purine 5'-nucleotidase isoform X2 [Pongo abelii]","gi|982967892|ref|XM_005225434.3|",1863,0,"PREDICTED: Bos taurus 5'-nucleotidase, cytosolic II (NT5C2), transcript variant X2, mRNA","O46411",769,0,"Cytosolic purine 5'-nucleotidase",".",".",".",".","pfam05761","5_nucleotid","5' nucleotidase family. This family of eukaryotic proteins includes 5' nucleotidase enzymes, such as purine 5'-nucleotidase EC:3.1.3.5.","GO:0046085|adenosine metabolic process;GO:0046040|IMP metabolic process;","GO:0005737|cytoplasm;","GO:0008253|5'-nucleotidase activity;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0000166|nucleotide binding;","K01081","E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]"]
["gene3076",11,5,15,9.11226850535281,86,80,100,97.6003501203797,0.0933630718958875,-3.42100415940584,{"v":8.6003394691388e-07,"d":"8.60E-07"},{"v":5.29970378820732e-05,"d":"5.30E-05"},"down","yes","CD5L","protein_coding","chrNC_037330.1:12508921-12526879:+","gi|156120885|ref|NP_001095589.1|",2363,0,"CD5 antigen-like precursor [Bos taurus]","gi|982916186|ref|XM_015461806.1|",2438,0,"PREDICTED: Bos taurus CD5 molecule-like (CD5L), transcript variant X1, mRNA","O43866",434,{"v":8e-144,"d":"8.00E-144"},"CD5 antigen-like",".",".",".",".","pfam00530","SRCR","Scavenger receptor cysteine-rich domain. These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.","GO:0006915|apoptotic process;GO:0006968|cellular defense response;GO:0002376|immune system process;GO:0006954|inflammatory response;","GO:0072562|blood microparticle;GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0016020|membrane;","GO:0005044|scavenger receptor activity;",".","."]
["gene30808",1,4,6,3.41422375531119,31,21,21,26.8739804020278,0.1270457038457,-2.97658050458304,0.00380067934230049,0.0489716482229324,"down","yes","HABP2","protein_coding","chrNC_037353.1:34026815-34062274:+","gi|62460436|ref|NP_001014868.1|",2913,0,"hyaluronan-binding protein 2 precursor [Bos taurus]","gi|62460435|ref|NM_001014868.1|",2912,0,"Bos taurus hyaluronan binding protein 2 (HABP2), mRNA","Q5E9Z2",1126,0,"Hyaluronan-binding protein 2","mlr3307",102,{"v":2e-22,"d":"2.00E-22"},"COG5640","pfam00089","Trypsin","Trypsin.",".","GO:0005576|extracellular region;","GO:0005509|calcium ion binding;GO:0004252|serine-type endopeptidase activity;","K08648","HABP2; hyaluronan binding protein 2 [EC:3.4.21.-]"]
["gene30839",123,39,50,60.1937293003162,144,160,130,159.467091523856,0.377468032589729,-1.40557362575324,0.0030227059164233,0.0415818816304114,"down","yes","SHTN1","protein_coding","chrNC_037353.1:37270823-37380596:-","gi|528926576|ref|XP_003584156.2|",2916,0,"PREDICTED: shootin-1 isoform X1 [Bos taurus]","gi|594097005|ref|XM_006071689.1|",3514,0,"PREDICTED: Bubalus bubalis KIAA1598 ortholog (KIAA1598), transcript variant X1, mRNA","A0MZ66",963,0,"Shootin-1",".",".",".",".","pfam02463","SMC_N","RecF/RecN/SMC N terminal domain. This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics.   This family also includes the RecF and RecN proteins that are involved in DNA metabolizm and recombination.","GO:0061573|actin filament bundle retrograde transport;GO:0007409|axonogenesis;GO:0032488|Cdc42 protein signal transduction;GO:0060327|cytoplasmic actin-based contraction involved in cell motility;GO:0061163|endoplasmic reticulum polarization;GO:0038007|netrin-activated signaling pathway;GO:0048812|neuron projection morphogenesis;GO:0045773|positive regulation of axon extension;GO:2001224|positive regulation of neuron migration;GO:0007265|Ras protein signal transduction;GO:2000114|regulation of establishment of cell polarity;GO:0006930|substrate-dependent cell migration, cell extension;","GO:0030424|axon;GO:0044295|axonal growth cone;GO:0031252|cell leading edge;GO:0005737|cytoplasm;GO:0030175|filopodium;GO:0030426|growth cone;GO:0030027|lamellipodium;GO:0005874|microtubule;GO:0005875|microtubule associated complex;GO:0015630|microtubule cytoskeleton;GO:0043204|perikaryon;GO:0048471|perinuclear region of cytoplasm;","GO:0051015|actin filament binding;GO:0045296|cadherin binding;GO:0019894|kinesin binding;",".","."]
["gene30847",65,143,49,78.8530985676933,290,253,282,303.03495565176,0.260211230081024,-1.94224486829442,{"v":4.20075963797367e-05,"d":"4.20E-05"},0.00139200781917569,"down","yes","EMX2","protein_coding","chrNC_037353.1:37830529-37837034:+","gi|115496181|ref|NP_001069313.1|",1083,{"v":8e-140,"d":"8.00E-140"},"homeobox protein EMX2 [Bos taurus]","gi|115496180|ref|NM_001075845.1|",2153,0,"Bos taurus empty spiracles homeobox 2 (EMX2), mRNA","Q17R00",421,{"v":3e-141,"d":"3.00E-141"},"Homeobox protein EMX2",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009952|anterior/posterior pattern specification;GO:0021846|cell proliferation in forebrain;GO:0021796|cerebral cortex regionalization;GO:0021542|dentate gyrus development;GO:0021885|forebrain cell migration;GO:0030182|neuron differentiation;GO:0006355|regulation of transcription, DNA-templated;GO:0072001|renal system development;GO:0042493|response to drug;","GO:0005634|nucleus;","GO:0043565|sequence-specific DNA binding;","K09317","EMX; homeobox protein EMX"]
["gene30874",1570,959,1205,1093.54130468974,3186,1508,2478,2638.73320695226,0.414419048431493,-1.27083777804515,0.00236069177684567,0.034717988188239,"down","yes","INPP5F","protein_coding","chrNC_037353.1:39852056-39946253:+","gi|742199661|ref|XP_010857553.1|",5771,0,"PREDICTED: phosphatidylinositide phosphatase SAC2 isoform X1 [Bison bison bison]","gi|742199660|ref|XM_010859251.1|",4651,0,"PREDICTED: Bison bison bison inositol polyphosphate-5-phosphatase F (INPP5F), transcript variant X1, mRNA","Q9Y2H2",2068,0,"Phosphatidylinositide phosphatase SAC2","YKL212w",275,{"v":7e-78,"d":"7.00E-78"},"COG5329","pfam02383","Syja_N","SacI homology domain. This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.","GO:0008344|adult locomotory behavior;GO:0014898|cardiac muscle hypertrophy in response to stress;GO:0072583|clathrin-mediated endocytosis;GO:0048681|negative regulation of axon regeneration;GO:0033137|negative regulation of peptidyl-serine phosphorylation;GO:0042532|negative regulation of tyrosine phosphorylation of STAT protein;GO:0006661|phosphatidylinositol biosynthetic process;GO:0031161|phosphatidylinositol catabolic process;GO:0046856|phosphatidylinositol dephosphorylation;GO:0048015|phosphatidylinositol-mediated signaling;GO:0001921|positive regulation of receptor recycling;GO:2000145|regulation of cell motility;GO:2001135|regulation of endocytic recycling;GO:0051896|regulation of protein kinase B signaling;","GO:0030424|axon;GO:0045334|clathrin-coated endocytic vesicle;GO:0005905|coated pit;GO:0030425|dendrite;GO:0005769|early endosome;GO:0031901|early endosome membrane;GO:0043025|neuronal cell body;GO:0055037|recycling endosome;","GO:0008934|inositol monophosphate 1-phosphatase activity;GO:0052832|inositol monophosphate 3-phosphatase activity;GO:0052833|inositol monophosphate 4-phosphatase activity;GO:0034596|phosphatidylinositol phosphate 4-phosphatase activity;GO:0034595|phosphatidylinositol phosphate 5-phosphatase activity;GO:0042803|protein homodimerization activity;",".","."]
["gene3089",3089,2068,2293,2187.01524504967,6569,4560,5648,6167.52077300028,0.354602007118293,-1.49572739268512,{"v":2.31109502673799e-06,"d":"2.31E-06"},0.000123248321883854,"down","yes","LOC784007","protein_coding","chrNC_037330.1:13041461-13066960:-","gi|741874121|ref|XP_010825068.1|",1771,0,"PREDICTED: T-lymphocyte surface antigen Ly-9 isoform X1 [Bos taurus]","gi|982978341|ref|XM_010826766.2|",8025,0,"PREDICTED: Bos taurus T-lymphocyte surface antigen Ly-9 (LOC784007), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam13927","Ig_3","Immunoglobulin domain. This family contains immunoglobulin-like domains.",".",".",".",".","."]
["gene31050",343,360,608,394.102087982919,870,571,804,824.950342670228,0.477728255384773,-1.06573788691224,0.00186632929346684,0.0292584909034581,"down","yes","ZNF705A","protein_coding","chrNC_037354.1:6108016-6125693:+","gi|594110667|ref|XP_006078170.1|",1634,0,"PREDICTED: zinc finger protein 596-like isoform X5 [Bubalus bubalis]","gi|942078612|ref|XM_005903784.2|",2671,0,"PREDICTED: Bos mutus zinc finger protein 596 (LOC102265540), mRNA","Q6ZN79",357,{"v":6e-114,"d":"6.00E-114"},"Zinc finger protein 705A",".",".",".",".","pfam01352","KRAB","KRAB box. The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K09228","KRAB; KRAB domain-containing zinc finger protein"]
["gene3106",4,2,0,1.69792830575803,25,14,27,24.2282962087118,0.0700803841562537,-3.8348455064623,0.00140582681070964,0.0236774762316155,"down","yes","SH2D2A","protein_coding","chrNC_037330.1:14027673-14037570:+","gi|157427928|ref|NP_001098871.1|",1819,0,"SH2 domain-containing protein 2A [Bos taurus]","gi|402692512|ref|NM_001105401.2|",2250,0,"Bos taurus SH2 domain containing 2A (SH2D2A), mRNA","Q9NP31",483,{"v":5e-163,"d":"5.00E-163"},"SH2 domain-containing protein 2A",".",".",".",".","pfam00017","SH2","SH2 domain.","GO:0001525|angiogenesis;GO:0030154|cell differentiation;GO:0008283|cell proliferation;GO:0007165|signal transduction;GO:0048010|vascular endothelial growth factor receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005829|cytosol;","GO:0017124|SH3 domain binding;GO:0005070|SH3/SH2 adaptor activity;","K08273","SH2D2A, VRAP; SH2 domain protein 2A"]
["gene3112",36,88,33,48.356606205351,100,151,132,140.440353211722,0.344321308651585,-1.53817262866235,0.00339417497739838,0.0452097134827979,"down","yes","CRABP2","protein_coding","chrNC_037330.1:14125444-14130428:+","gi|440903652|gb|ELR54289.1|",742,{"v":2e-98,"d":"2.00E-98"},"Cellular retinoic acid-binding protein 2, partial [Bos mutus]","gi|148744838|gb|BC142037.1|",430,0,"Bos taurus cellular retinoic acid binding protein 2, mRNA (cDNA clone MGC:159737 IMAGE:8634038), complete cds","Q5PXY7",283,{"v":3e-97,"d":"3.00E-97"},"Cellular retinoic acid-binding protein 2",".",".",".",".","pfam00061","Lipocalin","Lipocalin / cytosolic fatty-acid binding protein family. Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.","GO:0048385|regulation of retinoic acid receptor signaling pathway;","GO:0005737|cytoplasm;GO:0005783|endoplasmic reticulum;GO:0005634|nucleus;","GO:0016918|retinal binding;GO:0001972|retinoic acid binding;GO:0019841|retinol binding;","K17289","CRABP2; cellular retinoic acid-binding protein 2"]
["gene31143",184,83,95,104.33179814478,307,224,272,295.136644799677,0.353503368636567,-1.50020413192591,0.000176253714612217,0.00459661310018389,"down","yes","CASP3","protein_coding","chrNC_037354.1:15047753-15072825:-","gi|741977192|ref|XP_010818547.1|",1491,0,"PREDICTED: caspase-3 isoform X1 [Bos taurus]","gi|982969144|ref|XM_010820245.2|",3078,0,"PREDICTED: Bos taurus caspase 3, apoptosis-related cysteine peptidase (CASP3), transcript variant X1, mRNA","Q08DY9",571,0,"Caspase-3",".",".",".",".","pfam00656","Peptidase_C14","Caspase domain.","GO:0030218|erythrocyte differentiation;GO:0097194|execution phase of apoptosis;GO:0030216|keratinocyte differentiation;GO:0030182|neuron differentiation;","GO:0005737|cytoplasm;","GO:0097200|cysteine-type endopeptidase activity involved in execution phase of apoptosis;","K02187","CASP3; caspase 3 [EC:3.4.22.56]"]
["gene31163",205,87,210,146.434744700098,420,395,478,474.487728309131,0.308616505682724,-1.69611287150814,{"v":3.50713105252722e-06,"d":"3.51E-06"},0.000173718673714677,"down","yes","TLR3","protein_coding","chrNC_037354.1:16176313-16187575:+","gi|741977187|ref|XP_010818544.1|",4249,0,"PREDICTED: toll-like receptor 3 isoform X1 [Bos taurus]","gi|982969138|ref|XM_010820242.2|",3171,0,"PREDICTED: Bos taurus toll like receptor 3 (TLR3), transcript variant X1, mRNA","Q5TJ59",1599,0,"Toll-like receptor 3","alr0124_1",70.5,{"v":1e-11,"d":"1.00E-11"},"COG4886","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0051607|defense response to virus;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0002756|MyD88-independent toll-like receptor signaling pathway;GO:0032722|positive regulation of chemokine production;GO:0050729|positive regulation of inflammatory response;GO:0043331|response to dsRNA;GO:0043330|response to exogenous dsRNA;GO:0034138|toll-like receptor 3 signaling pathway;GO:0002224|toll-like receptor signaling pathway;","GO:0005769|early endosome;GO:0005789|endoplasmic reticulum membrane;GO:0010008|endosome membrane;GO:0005887|integral component of plasma membrane;","GO:0003725|double-stranded RNA binding;GO:0004888|transmembrane signaling receptor activity;","K05401","TLR3; toll-like receptor 3"]
["gene31164",45,27,49,35.6253830430045,127,88,94,113.694905039156,0.313341948179078,-1.67419017363404,0.0016919447016449,0.0273036619245648,"down","yes","FAM149A","protein_coding","chrNC_037354.1:16201930-16244222:+","gi|529009711|ref|XP_005226030.1|",3352,0,"PREDICTED: protein FAM149A isoform X1 [Bos taurus]","gi|965823623|ref|XM_012127357.2|",3204,0,"PREDICTED: Ovis aries musimon family with sequence similarity 149 member A (FAM149A), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam12516","DUF3719","Protein of unknown function (DUF3719). This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved HLR sequence motif. There are two completely conserved residues (W and H) that may be functionally important.",".",".",".",".","."]
["gene31167",264,115,125,144.882271834531,461,344,404,444.38386024271,0.326029554168327,-1.61692534601536,{"v":1.26693186693533e-05,"d":"1.27E-05"},0.000523109017301474,"down","yes","CYP4V2","protein_coding","chrNC_037354.1:16250061-16266693:+","gi|529009695|ref|XP_005226022.1|",2737,0,"PREDICTED: cytochrome P450 4V2 isoform X1 [Bos taurus]","gi|402745110|ref|NM_001034373.2|",4209,0,"Bos taurus cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2), mRNA","Q5RCN6",832,0,"Cytochrome P450 4V2","BH0579",166,{"v":1e-42,"d":"1.00E-42"},"COG2124","pfam00067","p450","Cytochrome P450. Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.","GO:0010430|fatty acid omega-oxidation;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0020037|heme binding;GO:0005506|iron ion binding;GO:0004497|monooxygenase activity;GO:0016705|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;","K07427","CYP4V; cytochrome P450, family 4, subfamily V"]
["gene31267",194,97,97,112.14032128925,293,230,255,285.96927784732,0.392141149333957,-1.35055505587615,0.00063178259498361,0.0127839639840265,"down","yes","UBXN8","protein_coding","chrNC_037354.1:26867669-26885080:+","gi|84579835|ref|NP_001033761.1|",1111,{"v":7e-148,"d":"7.00E-148"},"UBX domain-containing protein 8 [Bos taurus]","gi|402746851|ref|NM_001038672.2|",1279,0,"Bos taurus UBX domain protein 8 (UBXN8), mRNA","Q2TBH5",432,{"v":2e-149,"d":"2.00E-149"},"UBX domain-containing protein 8",".",".",".",".","pfam00789","UBX","UBX domain. This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module.","GO:0030433|ER-associated ubiquitin-dependent protein catabolic process;","GO:0030176|integral component of endoplasmic reticulum membrane;GO:0005730|nucleolus;GO:0005654|nucleoplasm;",".",".","."]
["gene31270",9,67,8,26.7596667072324,4310,114,2516,2560.98483891,0.0104489750586035,-6.58049475468285,0.000646694147510651,0.0129843988195823,"down","yes","TEX15","protein_coding","chrNC_037354.1:26935464-27017834:-","gi|742113564|ref|XP_010837109.1|",14721,0,"PREDICTED: testis-expressed sequence 15 protein isoform X1 [Bison bison bison]","gi|742113563|ref|XM_010838807.1|",10593,0,"PREDICTED: Bison bison bison testis expressed 15 (TEX15), transcript variant X1, mRNA","Q9BXT5",2556,0,"Testis-expressed protein 15",".",".",".",".","pfam15326","TEX15","Testis expressed sequence 15. TEX15 is a family of eukaryotic proteins that is required for chromosomal synapsis and meiotic recombination. TEX15 regulates the loading of DNA repair proteins onto sites of double-stranded-breaks and, thus, its absence causes a failure in meiotic recombination. Two polymorphisms in the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.","GO:0030154|cell differentiation;GO:0006281|DNA repair;GO:0007140|male meiosis;GO:0010569|regulation of double-strand break repair via homologous recombination;GO:0007283|spermatogenesis;GO:0007129|synapsis;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".",".","."]
["gene31379",3520,2028,3607,2689.79297951886,8279,5567,7223,7744.75298850266,0.347305199211898,-1.5257240866405,{"v":4.60123606856374e-06,"d":"4.60E-06"},0.000219528204468549,"down","yes","SLC20A2","protein_coding","chrNC_037354.1:37252164-37369126:-","gi|529010092|ref|XP_005226170.1|",2866,0,"PREDICTED: sodium-dependent phosphate transporter 2 isoform X1 [Bos taurus]","gi|741977571|ref|XM_010820335.1|",8519,0,"PREDICTED: Bos taurus solute carrier family 20 (phosphate transporter), member 2 (SLC20A2), transcript variant X2, mRNA","A1A4I1",1107,0,"Sodium-dependent phosphate transporter 2","VC2442",149,{"v":1e-36,"d":"1.00E-36"},"COG0306","pfam01384","PHO4","Phosphate transporter family. This family includes PHO-4 from Neurospora crassa which is a is a Na(+)-phosphate symporter. This family also contains the leukaemia virus receptor.","GO:0006817|phosphate ion transport;GO:0016032|viral process;","GO:0005887|integral component of plasma membrane;","GO:0005315|inorganic phosphate transmembrane transporter activity;GO:0015319|sodium:inorganic phosphate symporter activity;","K14640","SLC20A, PIT; solute carrier family 20 (sodium-dependent phosphate transporter)"]
["gene31381",51,9,31,25.7620148333573,130,86,108,119.135854610077,0.216240651629809,-2.20929033041007,0.00015718294522092,0.00422268842172665,"down","yes","LOC107131913","pseudogene","chrNC_037354.1:37302362-37303274:-","gi|664706122|ref|XP_008542453.1|",201,{"v":6e-36,"d":"6.00E-36"},"PREDICTED: 60S ribosomal protein L12 [Equus przewalskii]","gi|850495373|gb|CP011911.1|",677,0,"Ovis canadensis canadensis isolate 43U chromosome 26 sequence","P30050",85.5,{"v":6e-27,"d":"6.00E-27"},"60S ribosomal protein L12","SPCC31H12.04c",69.7,{"v":5e-18,"d":"5.00E-18"},"COG0080","pfam12783","Sec7_N","Guanine nucleotide exchange factor in Golgi transport N-terminal. The full-length Sec7 functions proximally in the secretory pathway as a protein binding scaffold for the coat protein complexes COPII-COPI. The COPII-COPI-protein switch is necessary for maturation of the vesicular-tubular cluster, VTC, intermediate compartments for Golgi compartment biogenesis. This N-terminal domain however does not appear to be binding either of the COP or the ARF.","GO:0000184|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000027|ribosomal large subunit assembly;GO:0006614|SRP-dependent cotranslational protein targeting to membrane;GO:0006412|translation;GO:0006413|translational initiation;","GO:0005829|cytosol;GO:0022625|cytosolic large ribosomal subunit;GO:0070062|extracellular exosome;GO:0005925|focal adhesion;GO:0016020|membrane;","GO:0003723|RNA binding;GO:0019843|rRNA binding;GO:0003735|structural constituent of ribosome;","K02870","RP-L12e, RPL12; large subunit ribosomal protein L12e"]
["gene31522",1790,1846,2562,1858.32805505614,4347,3651,3902,4373.1577131587,0.424939637887855,-1.23467017200089,{"v":2.47265111308314e-05,"d":"2.47E-05"},0.000902138221321933,"down","yes","TOMM20","protein_coding","chrNC_037355.1:7883316-7898012:-","gi|440901027|gb|ELR52036.1|",644,{"v":7e-78,"d":"7.00E-78"},"Mitochondrial import receptor subunit TOM20-like protein, partial [Bos mutus]","gi|149643098|ref|NM_001099183.1|",1684,0,"Bos taurus translocase of outer mitochondrial membrane 20 homolog (yeast) (TOMM20), mRNA","Q5RA31",249,{"v":4e-78,"d":"4.00E-78"},"Mitochondrial import receptor subunit TOM20 homolog",".",".",".",".","pfam02064","MAS20","MAS20 protein import receptor.","GO:0006626|protein targeting to mitochondrion;","GO:0044233|ER-mitochondrion membrane contact site;GO:0016021|integral component of membrane;GO:0005742|mitochondrial outer membrane translocase complex;","GO:0015450|P-P-bond-hydrolysis-driven protein transmembrane transporter activity;GO:0051082|unfolded protein binding;","K17770","TOM20; mitochondrial import receptor subunit TOM20"]
["gene31540",92,35,66,55.7174843792969,157,139,170,171.058253285611,0.325722280621368,-1.61828568604534,0.000547254963051492,0.0112979242770059,"down","yes","GPR137B","protein_coding","chrNC_037355.1:8841688-8897396:+","gi|594105206|ref|XP_006075562.1|",2057,0,"PREDICTED: LOW QUALITY PROTEIN: integral membrane protein GPR137B [Bubalus bubalis]","gi|347300430|ref|NM_001191481.1|",2027,0,"Bos taurus G protein-coupled receptor 137B (GPR137B), mRNA","O60478",748,0,"Integral membrane protein GPR137B",".",".",".",".","pfam07695","7TMR-DISM_7TM","7TM diverse intracellular signalling. This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules).",".","GO:0005887|integral component of plasma membrane;GO:0005765|lysosomal membrane;GO:0016020|membrane;",".",".","."]
["gene31720",3263,2028,4201,2805.24305801516,8022,4947,6870,7293.73886692769,0.384609746687682,-1.3785327713156,0.000146096497511555,0.00399643256999249,"down","yes","MCU","protein_coding","chrNC_037355.1:28709011-28904117:+","gi|594073664|ref|XP_006060648.1|",1592,0,"PREDICTED: calcium uniporter protein, mitochondrial-like isoform X1 [Bubalus bubalis]","gi|982970356|ref|XM_015461006.1|",2924,0,"PREDICTED: Bos taurus mitochondrial calcium uniporter (MCU), transcript variant X1, mRNA","Q8NE86",572,0,"Calcium uniporter protein, mitochondrial",".",".",".",".","pfam04678","DUF607","Protein of unknown function, DUF607. This family represents a conserved region found in several uncharacterized eukaryotic proteins.","GO:0036444|calcium ion transmembrane import into mitochondrion;GO:0019722|calcium-mediated signaling;GO:0042593|glucose homeostasis;GO:0006851|mitochondrial calcium ion transport;GO:0032024|positive regulation of insulin secretion;GO:0051561|positive regulation of mitochondrial calcium ion concentration;GO:0051259|protein oligomerization;","GO:0034704|calcium channel complex;GO:0031305|integral component of mitochondrial inner membrane;GO:0005743|mitochondrial inner membrane;GO:0005739|mitochondrion;GO:1990246|uniplex complex;","GO:0005262|calcium channel activity;GO:0042802|identical protein binding;GO:0015292|uniporter activity;",".","."]
["gene31741",10972,22058,17971,15607.6376000771,38664,29517,35758,38191.4100580808,0.408668796892842,-1.29099600148349,0.00116909782714268,0.0204134211176303,"down","yes","SYNPO2L","protein_coding","chrNC_037355.1:29625247-29634849:-","gi|741978639|ref|XP_010818963.1|",3149,0,"PREDICTED: synaptopodin 2-like protein isoform X2 [Bos taurus]","gi|982970611|ref|XM_010820661.2|",4716,0,"PREDICTED: Bos taurus synaptopodin 2-like (SYNPO2L), transcript variant X2, mRNA","Q9H987",1025,0,"Synaptopodin 2-like protein",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0032233|positive regulation of actin filament bundle assembly;","GO:0015629|actin cytoskeleton;GO:0030054|cell junction;GO:0005829|cytosol;GO:0016607|nuclear speck;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0030018|Z disc;","GO:0003779|actin binding;",".","."]
["gene31841",4,2,9,4.46202300823095,51,38,55,52.8612090859563,0.0844101579473024,-3.56643956597993,{"v":4.28553579304743e-05,"d":"4.29E-05"},0.00141353319897614,"down","yes","SNCG","protein_coding","chrNC_037355.1:41570937-41575651:+","gi|27806399|ref|NP_776611.1|",433,{"v":8e-51,"d":"8.00E-51"},"gamma-synuclein [Bos taurus]","gi|92096990|gb|BC114910.1|",649,0,"Bos taurus synuclein, gamma (breast cancer-specific protein 1), mRNA (cDNA clone MGC:140591 IMAGE:8272238), complete cds","Q9NZ50",171,{"v":3e-52,"d":"3.00E-52"},"Gamma-synuclein",".",".",".",".","pfam01387","Synuclein","Synuclein. There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.","GO:0008344|adult locomotory behavior;GO:0007268|synaptic transmission;GO:0009306|protein secretion;GO:0014059|regulation of dopamine secretion;GO:0046928|regulation of neurotransmitter secretion;GO:0007165|signal transduction;GO:0050808|synapse organization;","GO:0030424|axon;GO:0005815|microtubule organizing center;GO:0043025|neuronal cell body;GO:0048471|perinuclear region of cytoplasm;GO:0005819|spindle;",".",".","."]
["gene31867",423,42,110,157.791151405285,335,485,383,441.453897449408,0.35743517571587,-1.48424647580264,0.000641735185289417,0.0129286395742498,"down","yes","WDFY4","protein_coding","chrNC_037355.1:43020183-43268436:+","gi|529011280|ref|XP_005226638.1|",15967,0,"PREDICTED: WD repeat- and FYVE domain-containing protein 4 isoform X3 [Bos taurus]","gi|982970755|ref|XM_010820713.2|",5544,0,"PREDICTED: Bos taurus WDFY family member 4 (WDFY4), transcript variant X2, mRNA","Q6ZS81",5209,0,"WD repeat- and FYVE domain-containing protein 4",".",".",".",".","pfam02138","Beach","Beige/BEACH domain.",".","GO:0016021|integral component of membrane;",".",".","."]
["gene31915",88,47,38,50.0081978414043,169,116,203,179.014861600029,0.279352213522568,-1.83984284296706,0.000106678724805655,0.00305034687887527,"down","yes","AGT","protein_coding","chrNC_037355.1:45757544-45766377:+","gi|166159174|ref|NP_001107554.1|",2053,0,"angiotensinogen precursor [Bos taurus]","gi|402693410|ref|NM_001114082.2|",1644,0,"Bos taurus angiotensinogen (AGT), mRNA","P20757",649,0,"Angiotensinogen",".",".",".",".","pfam00079","Serpin","Serpin (serine protease inhibitor). Structure is a multi-domain fold containing a bundle of helices and a beta sandwich.","GO:0003081|regulation of systemic arterial blood pressure by renin-angiotensin;GO:0042310|vasoconstriction;","GO:0005615|extracellular space;",".",".","."]
["gene32018",352,125,249,209.177376035588,514,344,376,454.086328145818,0.460655525326488,-1.11823977736242,0.00335627243597473,0.0448724502674765,"down","yes","ME3","protein_coding","chrNC_037356.1:8891377-9112320:+","gi|115495175|ref|NP_001069345.1|",3178,0,"NADP-dependent malic enzyme, mitochondrial [Bos taurus]","gi|115495174|ref|NM_001075877.1|",2000,0,"Bos taurus malic enzyme 3, NADP(+)-dependent, mitochondrial (ME3), mRNA","Q16798",1169,0,"NADP-dependent malic enzyme, mitochondrial","VC1188",410,{"v":1e-133,"d":"1.00E-133"},"COG0281","pfam03949","Malic_M","Malic enzyme, NAD binding domain.","GO:0009060|aerobic respiration;GO:0006108|malate metabolic process;GO:0055114|oxidation-reduction process;GO:0072592|oxygen metabolic process;GO:0006090|pyruvate metabolic process;GO:0006099|tricarboxylic acid cycle;","GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;","GO:0048037|cofactor binding;GO:0004471|malate dehydrogenase (decarboxylating) (NAD+) activity;GO:0004473|malate dehydrogenase (decarboxylating) (NADP+) activity;GO:0004470|malic enzyme activity;GO:0046872|metal ion binding;GO:0051287|NAD binding;GO:0008948|oxaloacetate decarboxylase activity;","K00029","E1.1.1.40, maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]"]
["gene32035",1377,400,1508,953.104692287117,3070,3819,3155,3687.86302590826,0.258443625913243,-1.95207847386375,{"v":7.22334696491417e-08,"d":"7.22E-08"},{"v":6.24513067442321e-06,"d":"6.25E-06"},"down","yes","DLG2","protein_coding","chrNC_037356.1:9932887-12255824:+","gi|965994299|ref|XP_014958398.1|",5050,0,"PREDICTED: disks large homolog 2 isoform X18 [Ovis aries]","gi|983009405|ref|XM_015469933.1|",5672,0,"PREDICTED: Bos taurus disks large homolog 2 (LOC505383), transcript variant X1, mRNA","Q15700",1664,0,"Disks large homolog 2","YDR454c",101,{"v":2e-22,"d":"2.00E-22"},"COG0194","pfam00625","Guanylate_kin","Guanylate kinase.","GO:0035865|cellular response to potassium ion;GO:0007268|synaptic transmission;GO:0010923|negative regulation of phosphatase activity;GO:0007399|nervous system development;GO:0043113|receptor clustering;GO:0097120|receptor localization to synapse;GO:0019233|sensory perception of pain;","GO:1904115|axon cytoplasm;GO:0030054|cell junction;GO:0005829|cytosol;GO:0044224|juxtaparanode region of axon;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;","GO:0004385|guanylate kinase activity;GO:0035255|ionotropic glutamate receptor binding;GO:0019900|kinase binding;","K12075","DLG2_3; discs large protein 2/3"]
["gene32039",12,3,4,5.33911841408672,48,61,72,66.3171580058639,0.0805088543392439,-3.63470873066119,{"v":9.37409469348714e-06,"d":"9.37E-06"},0.00040708111978673,"down","yes","LOC107131950","pseudogene","chrNC_037356.1:11877134-11878755:+","gi|826300801|ref|XP_012502247.1|",401,{"v":3e-40,"d":"3.00E-40"},"PREDICTED: L-lactate dehydrogenase A-like 6B [Propithecus coquereli]","gi|850493339|gb|CP011906.1|",957,0,"Ovis canadensis canadensis isolate 43U chromosome 21 sequence","Q9BYZ2",154,{"v":4e-40,"d":"4.00E-40"},"L-lactate dehydrogenase A-like 6B","BH3937",69.7,{"v":3e-12,"d":"3.00E-12"},"COG0039","pfam00056","Ldh_1_N","lactate/malate dehydrogenase, NAD binding domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.","GO:0005975|carbohydrate metabolic process;GO:0006090|pyruvate metabolic process;","GO:0005759|mitochondrial matrix;GO:0005634|nucleus;","GO:0004459|L-lactate dehydrogenase activity;","K00016","LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]"]
["gene32071",4,62,89,48.6948144492746,160,158,179,182.401077363044,0.266965607622779,-1.90527419907181,0.000561884895422133,0.0115331927707114,"down","yes","THRSP","protein_coding","chrNC_037356.1:17989040-17994946:-","gi|555992716|ref|XP_005908129.1|",690,{"v":1e-85,"d":"1.00E-85"},"PREDICTED: thyroid hormone-inducible hepatic protein [Bos mutus]","gi|94966858|ref|NM_001040533.1|",1387,0,"Bos taurus thyroid hormone responsive (THRSP), mRNA","Q62264",199,{"v":6e-60,"d":"6.00E-60"},"Thyroid hormone-inducible hepatic protein",".",".",".",".","pfam07084","Spot_14","Thyroid hormone-inducible hepatic protein Spot 14. This family consists of several thyroid hormone-inducible hepatic protein (Spot 14 or S14) sequences. Mainly expressed in tissues that synthesize triglycerides, the mRNA coding for Spot 14 has been shown to be increased in rat liver by insulin, dietary carbohydrates, glucose in hepatocyte culture medium, as well as thyroid hormone. In contrast, dietary fats and polyunsaturated fatty acids, have been shown to decrease the amount of Spot 14 mRNA, while an elevated level of cAMP acts as a dominant negative factor. In addition, liver-specific factors or chromatin organisation of the gene have been shown to contribute to the regulation of its expression. Spot 14 protein is thought to be required for induction of hepatic lipogenesis.","GO:0006629|lipid metabolic process;GO:0046890|regulation of lipid biosynthetic process;GO:0006355|regulation of transcription, DNA-templated;GO:0010866|regulation of triglyceride biosynthetic process;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;",".","."]
["gene32121",9228,17549,34077,18621.9326903843,137728,145380,147180,157958.974027217,0.117890944816947,-3.08447518547034,{"v":9.67790047346398e-06,"d":"9.68E-06"},0.000418363906679395,"down","yes","CSRP3","protein_coding","chrNC_037356.1:25744235-25764912:+","gi|594042319|ref|XP_006045697.1|",1086,{"v":8e-147,"d":"8.00E-147"},"PREDICTED: cysteine and glycine-rich protein 3 isoform X1 [Bubalus bubalis]","gi|402692970|ref|NM_001024689.3|",899,0,"Bos taurus cysteine and glycine rich protein 3 (CSRP3), mRNA","Q4U0T9",399,{"v":1e-139,"d":"1.00E-139"},"Cysteine and glycine-rich protein 3",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0060048|cardiac muscle contraction;GO:0003300|cardiac muscle hypertrophy;GO:0055003|cardiac myofibril assembly;GO:0006874|cellular calcium ion homeostasis;GO:0035995|detection of muscle stretch;GO:0007517|muscle organ development;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0033365|protein localization to organelle;GO:0002026|regulation of the force of heart contraction;GO:0006351|transcription, DNA-templated;","GO:0005856|cytoskeleton;GO:0005634|nucleus;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0042805|actinin binding;GO:0042802|identical protein binding;GO:0046872|metal ion binding;GO:0008307|structural constituent of muscle;GO:0031433|telethonin binding;","K09377","CSRP; cysteine and glycine-rich protein"]
["gene32315",0,0,0,0,0,26,10,13.151405678258,{"$error":"#NAME?"},{"$error":"#NAME?"},0.0016104877288985,0.0262865133828393,"down","yes","KCNJ1","protein_coding","chrNC_037356.1:32212882-32244725:-","gi|529012010|ref|XP_005226881.1|",1898,0,"PREDICTED: ATP-sensitive inward rectifier potassium channel 1 isoform X1 [Bos taurus]","gi|742142755|ref|XM_010844682.1|",3456,0,"PREDICTED: Bison bison bison potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1), transcript variant X1, mRNA","P48048",705,0,"ATP-sensitive inward rectifier potassium channel 1",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.","GO:0007588|excretion;GO:0010107|potassium ion import;GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;","GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0005524|ATP binding;GO:0015272|ATP-activated inward rectifier potassium channel activity;GO:0005242|inward rectifier potassium channel activity;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;","K04995","KCNJ1; potassium inwardly-rectifying channel subfamily J member 1"]
["gene32345",0,0,0,0,17,7,3,10.0058891814289,{"$error":"#NAME?"},{"$error":"#NAME?"},0.00370087648850694,0.0481704868127699,"down","yes","ST14","protein_coding","chrNC_037356.1:36351333-36389421:+","gi|115496059|ref|NP_001070006.1|",4317,0,"suppressor of tumorigenicity 14 protein homolog [Bos taurus]","gi|115496058|ref|NM_001076538.1|",1486,0,"Bos taurus suppression of tumorigenicity 14 (ST14), mRNA","Q0IIH7",1663,0,"Suppressor of tumorigenicity 14 protein homolog","mlr3307",117,{"v":3e-27,"d":"3.00E-27"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0030216|keratinocyte differentiation;","GO:0016021|integral component of membrane;","GO:0004252|serine-type endopeptidase activity;","K08670","ST14, PRSS14; suppressor of tumorigenicity protein 14 [EC:3.4.21.109]"]
["gene32517",0,0,0,0,0,35,11,16.8152666876162,{"$error":"#NAME?"},{"$error":"#NAME?"},0.000507000230973087,0.0106528162800675,"down","yes","SLC22A6","protein_coding","chrNC_037356.1:41285418-41293425:-","gi|741979815|ref|XP_010819299.1|",2597,0,"PREDICTED: solute carrier family 22 member 6 isoform X1 [Bos taurus]","gi|982971676|ref|XM_010820997.2|",1995,0,"PREDICTED: Bos taurus solute carrier family 22 (organic anion transporter), member 6 (SLC22A6), transcript variant X1, mRNA","Q864Z3",877,0,"Solute carrier family 22 member 6",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0015742|alpha-ketoglutarate transport;GO:0015711|organic anion transport;GO:0097254|renal tubular secretion;GO:0043252|sodium-independent organic anion transport;GO:0015747|urate transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0005452|inorganic anion exchanger activity;GO:0008514|organic anion transmembrane transporter activity;GO:0015347|sodium-independent organic anion transmembrane transporter activity;GO:0015143|urate transmembrane transporter activity;","K08203","SLC22A6, OAT1; MFS transporter, OCT family, solute carrier family 22 (organic anion transporter), member 6"]
["gene32518",0,0,0,0,0,25,17,15.3112283284412,{"$error":"#NAME?"},{"$error":"#NAME?"},0.000641608208461288,0.0129286395742498,"down","yes","SLC22A8","protein_coding","chrNC_037356.1:41302544-41322828:-","gi|329664560|ref|NP_001193175.1|",2599,0,"solute carrier family 22 member 8 [Bos taurus]","gi|329664559|ref|NM_001206246.1|",2145,0,"Bos taurus solute carrier family 22 (organic anion transporter), member 8 (SLC22A8), mRNA","Q70BM6",874,0,"Solute carrier family 22 member 8",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0009636|response to toxic substance;GO:0043252|sodium-independent organic anion transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0005452|inorganic anion exchanger activity;GO:0015347|sodium-independent organic anion transmembrane transporter activity;","K08205","SLC22A8, OAT3; MFS transporter, OCT family, solute carrier family 22 (organic anion transporter), member 8"]
["gene32708",124,91,195,122.02830872907,382,197,366,347.192038715433,0.351472082080451,-1.50851799632546,0.00133478056034095,0.0227431132137288,"down","yes","CLCF1","protein_coding","chrNC_037356.1:45264289-45274026:-","gi|533139327|ref|XP_005384395.1|",1244,{"v":2e-163,"d":"2.00E-163"},"PREDICTED: cardiotrophin-like cytokine factor 1 isoform X1 [Chinchilla lanigera]","gi|742109159|ref|XM_010837709.1|",1687,0,"PREDICTED: Bison bison bison cardiotrophin-like cytokine factor 1 (CLCF1), transcript variant X1, mRNA","Q9QZM3",436,{"v":3e-148,"d":"3.00E-148"},"Cardiotrophin-like cytokine factor 1",".",".",".",".","pfam06875","PRF","Plethodontid receptivity factor PRF. This family consists of several plethodontid receptivity factor (PRF) proteins which seem to be specific to Plethodon jordani (Jordan's salamander). PRF is a courtship pheromone produced by males increase female receptivity.","GO:0030183|B cell differentiation;GO:0007166|cell surface receptor signaling pathway;GO:0007259|JAK-STAT cascade;GO:2000672|negative regulation of motor neuron apoptotic process;GO:0043524|negative regulation of neuron apoptotic process;GO:0048711|positive regulation of astrocyte differentiation;GO:0030890|positive regulation of B cell proliferation;GO:0008284|positive regulation of cell proliferation;GO:0051466|positive regulation of corticotropin-releasing hormone secretion;GO:0002639|positive regulation of immunoglobulin production;GO:0048295|positive regulation of isotype switching to IgE isotypes;GO:0002830|positive regulation of type 2 immune response;GO:0042531|positive regulation of tyrosine phosphorylation of STAT protein;GO:0070372|regulation of ERK1 and ERK2 cascade;GO:0050727|regulation of inflammatory response;GO:0051896|regulation of protein kinase B signaling;","GO:0097059|CNTFR-CLCF1 complex;GO:0097058|CRLF-CLCF1 complex;GO:0005576|extracellular region;GO:0005622|intracellular;","GO:0005127|ciliary neurotrophic factor receptor binding;GO:0005125|cytokine activity;GO:0046982|protein heterodimerization activity;GO:0005102|receptor binding;","K05421","BSF3, CLC; B-cell stimulating factor 3"]
["gene32789",0,1,0,0.327717679206592,14,39,10,23.1549973377091,0.0141532160175586,-6.14272627767848,0.000182826656997273,0.00469930391962991,"down","yes","PHLDA2","protein_coding","chrNC_037356.1:48689532-48690588:+","gi|594046130|ref|XP_006047524.1|",673,{"v":5e-86,"d":"5.00E-86"},"PREDICTED: pleckstrin homology-like domain family A member 2 [Bubalus bubalis]","gi|402693116|ref|NM_001076521.2|",792,0,"Bos taurus pleckstrin homology-like domain, family A, member 2 (PHLDA2), mRNA","Q0VC85",258,{"v":1e-85,"d":"1.00E-85"},"Pleckstrin homology-like domain family A member 2",".",".",".",".","pfam00169","PH","PH domain. PH stands for pleckstrin homology.",".","GO:0005737|cytoplasm;GO:0016020|membrane;",".",".","."]
["gene32793",872,218,679,507.241505808114,2112,914,1777,1766.27366730824,0.287181717757893,-1.79996418604518,0.00208622380843797,0.03174509412189,"down","yes","LOC112444897","protein_coding","chrNC_037356.1:48905879-48921626:+",".",".",".",".","gi|850493339|gb|CP011906.1|",2509,0,"Ovis canadensis canadensis isolate 43U chromosome 21 sequence",".",".",".",".",".",".",".",".","pfam03251","Tymo_45kd_70kd","Tymovirus 45/70Kd protein. Tymoviruses are single stranded RNA viruses. This family includes a protein of unknown function that has been named based on its molecular weight. Tymoviruses such as the ononis yellow mosaic tymovirus encode only three proteins. Of these two are overlapping this protein overlaps a larger ORF that is thought to be the polymerase.",".",".",".",".","."]
["gene328",260,201,228,203.657027560587,491,554,464,554.322665743234,0.367397979816546,-1.44458440125427,{"v":2.486503951515e-05,"d":"2.49E-05"},0.000905459137363729,"down","yes","DZIP3","protein_coding","chrNC_037328.1:53338813-53468674:+","gi|528936379|ref|XP_005201394.1|",6123,0,"PREDICTED: E3 ubiquitin-protein ligase DZIP3 isoform X1 [Bos taurus]","gi|982910155|ref|XM_015471157.1|",5268,0,"PREDICTED: Bos taurus DAZ interacting zinc finger protein 3 (DZIP3), transcript variant X2, mRNA","Q86Y13",2088,0,"E3 ubiquitin-protein ligase DZIP3",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0030968|endoplasmic reticulum unfolded protein response;GO:0000209|protein polyubiquitination;GO:0030433|ER-associated ubiquitin-dependent protein catabolic process;","GO:0005737|cytoplasm;GO:0036513|Derlin-1 retrotranslocation complex;GO:0044322|endoplasmic reticulum quality control compartment;GO:0000836|Hrd1p ubiquitin ligase complex;","GO:0046872|metal ion binding;GO:0019902|phosphatase binding;GO:0031593|polyubiquitin binding;GO:0003723|RNA binding;GO:0061630|ubiquitin protein ligase activity;GO:0004842|ubiquitin-protein transferase activity;GO:1990381|ubiquitin-specific protease binding;GO:0051082|unfolded protein binding;","K10642","DZIP3; E3 ubiquitin-protein ligase DZIP3 [EC:2.3.2.27]"]
["gene32816",78,51,120,73.8968101457329,300,152,288,271.872729416394,0.27180662916932,-1.87934745205256,0.000206898452833903,0.0051963202093346,"down","yes","IFITM10","protein_coding","chrNC_037356.1:49726614-49736579:+","gi|982972396|ref|XP_015316860.1|",946,{"v":5e-125,"d":"5.00E-125"},"PREDICTED: interferon-induced transmembrane protein 10 [Bos taurus]","gi|983009988|ref|XM_015470091.1|",1078,0,"PREDICTED: Bos taurus interferon induced transmembrane protein 10 (IFITM10), mRNA","Q8BR26",351,{"v":1e-119,"d":"1.00E-119"},"Interferon-induced transmembrane protein 10",".",".",".",".","pfam04505","Dispanin","Interferon-induced transmembrane protein. This family includes the human leukocyte antigen CD225, which is an interferon inducible transmembrane protein, and is associated with interferon induced cell growth suppression.","GO:0009607|response to biotic stimulus;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;",".","K06566","IFITM; interferon induced transmembrane protein"]
["gene33025",6,5,7,5.35217925230694,111,128,102,125.281901463402,0.0427210889185813,-4.54890776940151,{"v":2.91446939626955e-10,"d":"2.91E-10"},{"v":4.4466698580196e-08,"d":"4.45E-08"},"down","yes","XPNPEP2","protein_coding","chrNC_037357.1:13776127-13802300:+","gi|329663240|ref|NP_001192484.1|",3525,0,"xaa-Pro aminopeptidase 2 precursor [Bos taurus]","gi|329663239|ref|NM_001205555.1|",2652,0,"Bos taurus X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (XPNPEP2), mRNA","Q95333",1209,0,"Xaa-Pro aminopeptidase 2","VC0067",368,{"v":2e-114,"d":"2.00E-114"},"COG0006","pfam00557","Peptidase_M24","Metallopeptidase family M24. This family contains metallopeptidases. It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.",".","GO:0031225|anchored component of membrane;GO:0005886|plasma membrane;","GO:0046872|metal ion binding;GO:0070006|metalloaminopeptidase activity;","K14208","XPNPEP2; Xaa-Pro aminopeptidase 2 [EC:3.4.11.9]"]
["gene33027",24,5,14,12.1932489506155,39,60,55,56.4497185215054,0.216001944207574,-2.21088379691527,0.00263311297403405,0.0375064135108165,"down","yes","SASH3","protein_coding","chrNC_037357.1:13811589-13827151:+","gi|741981101|ref|XP_010819700.1|",1746,0,"PREDICTED: SAM and SH3 domain-containing protein 3 isoform X1 [Bos taurus]","gi|982972653|ref|XM_010821398.2|",3894,0,"PREDICTED: Bos taurus SAM and SH3 domain containing 3 (SASH3), transcript variant X1, mRNA","A0JN71",677,0,"SAM and SH3 domain-containing protein 3",".",".",".",".","pfam12485","SLY","Lymphocyte signaling adaptor protein. This domain family is found in eukaryotes, and is typically between 144 and 156 amino acids in length. The family is found in association with pfam07647, pfam07653. There is a conserved LGKK sequence motif. SLY contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes.","GO:0048873|homeostasis of number of cells within a tissue;GO:0030890|positive regulation of B cell proliferation;GO:0043372|positive regulation of CD4-positive, alpha-beta T cell differentiation;GO:0002639|positive regulation of immunoglobulin production;GO:0032729|positive regulation of interferon-gamma production;GO:0032733|positive regulation of interleukin-10 production;GO:0032743|positive regulation of interleukin-2 production;GO:0032753|positive regulation of interleukin-4 production;GO:0046622|positive regulation of organ growth;GO:0002726|positive regulation of T cell cytokine production;GO:0042102|positive regulation of T cell proliferation;GO:0032760|positive regulation of tumor necrosis factor production;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".",".","."]
["gene33065",24,62,32,36.401346070337,180,147,156,177.537199473433,0.205035035915299,-2.28605763968149,{"v":1.61413953163987e-05,"d":"1.61E-05"},0.000636535927691706,"down","yes","MBNL3","protein_coding","chrNC_037357.1:16204462-16325590:-","gi|741981163|ref|XP_010819719.1|",1485,0,"PREDICTED: muscleblind-like protein 3 isoform X3 [Bos taurus]","gi|982972698|ref|XM_010821417.2|",8531,0,"PREDICTED: Bos taurus muscleblind-like splicing regulator 3 (MBNL3), transcript variant X4, mRNA","Q9NUK0",495,{"v":2e-156,"d":"2.00E-156"},"Muscleblind-like protein 3",".",".",".",".","pfam08426","ICE2","ICE2. ICE2 is a fungal ER protein which has been shown to play an important role in forming/maintaining the cortical ER. It has also bee identified as a protein which is necessary for nuclear inner membrane targeting.","GO:0006397|mRNA processing;GO:0007275|multicellular organismal development;GO:0045662|negative regulation of myoblast differentiation;GO:0043484|regulation of RNA splicing;GO:0008380|RNA splicing;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0003723|RNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;","K14943","MBNL; muscleblind"]
["gene33141",69,82,153,91.8454629786787,239,184,231,240.241023480944,0.382305493241306,-1.38720216488206,0.000806912945785232,0.0153685135221619,"down","yes","LOC112445030","protein_coding","chrNC_037357.1:19763136-19824315:+","gi|942091513|ref|XP_014337691.1|",636,{"v":2e-77,"d":"2.00E-77"},"PREDICTED: four and a half LIM domains protein 1 isoform X4 [Bos mutus]","gi|164448593|ref|NM_001113259.1|",358,0,"Bos taurus four and a half LIM domains 1 (FHL1), transcript variant 2, mRNA","Q13642",218,{"v":3e-66,"d":"3.00E-66"},"Four and a half LIM domains protein 1",".",".",".",".","pfam00412","LIM","LIM domain. This family represents two copies of the LIM structural domain.","GO:0009887|organ morphogenesis;GO:0030154|cell differentiation;GO:0007517|muscle organ development;GO:0030308|negative regulation of cell growth;GO:2000134|negative regulation of G1/S transition of mitotic cell cycle;GO:0010972|negative regulation of G2/M transition of mitotic cell cycle;GO:0043268|positive regulation of potassium ion transport;GO:0003254|regulation of membrane depolarization;GO:1901016|regulation of potassium ion transmembrane transporter activity;","GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005925|focal adhesion;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0044325|ion channel binding;GO:0046872|metal ion binding;","K14365","FHL1, SLIM1; four and a half LIM domains protein 1"]
["gene33434",1547,857,1129,1030.77852280922,2261,1517,1883,2081.52174302246,0.49520430246022,-1.01390424578134,0.00172843745858681,0.0277356856754445,"down","yes","DIAPH2","protein_coding","chrNC_037357.1:45296052-46194365:+","gi|594100644|ref|XP_006073421.1|",2206,0,"PREDICTED: protein diaphanous homolog 2-like, partial [Bubalus bubalis]","gi|926727859|ref|XM_005700116.2|",3802,0,"PREDICTED: Capra hircus protein diaphanous homolog 2-like (LOC102191777), mRNA","O60879",818,0,"Protein diaphanous homolog 2",".",".",".",".","pfam02181","FH2","Formin Homology 2 Domain.","GO:0007015|actin filament organization;GO:0007292|female gamete generation;GO:0007275|multicellular organismal development;GO:0048477|oogenesis;","GO:0005829|cytosol;GO:0005769|early endosome;GO:0005783|endoplasmic reticulum;GO:0043231|intracellular membrane-bounded organelle;GO:0005730|nucleolus;","GO:0003779|actin binding;GO:0017048|Rho GTPase binding;GO:0005102|receptor binding;","K05741","DIAPH2; diaphanous 2"]
["gene33435",51,14,29,26.786359962174,108,75,77,95.6859338250754,0.279940414347029,-1.83680831441055,0.00169031135793625,0.0272927410035536,"down","yes","RPA4","protein_coding","chrNC_037357.1:45454593-45458355:+","gi|741905636|ref|XP_010800698.1|",1234,{"v":2e-156,"d":"2.00E-156"},"PREDICTED: LOW QUALITY PROTEIN: replication protein A 30 kDa subunit [Bos taurus]","gi|742090649|ref|XM_010833397.1|",3435,0,"PREDICTED: Bison bison bison replication protein A4, 30kDa (RPA4), mRNA","Q13156",283,{"v":2e-85,"d":"2.00E-85"},"Replication protein A 30 kDa subunit","SPCC1753.01c",75.9,{"v":6e-14,"d":"6.00E-14"},"COG5235","pfam08784","RPA_C","Replication protein A C terminal. This domain corresponds to the C terminal of the single stranded DNA binding protein RPA (replication protein A). RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoints.","GO:0000077|DNA damage checkpoint;GO:0006310|DNA recombination;GO:0006270|DNA replication initiation;GO:0000082|G1/S transition of mitotic cell cycle;GO:0006289|nucleotide-excision repair;","GO:0005662|DNA replication factor A complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003697|single-stranded DNA binding;","K10741","RPA4; replication factor A4"]
["gene33454",177,98,121,115.408363148836,334,186,279,293.809665832242,0.392799749531491,-1.34813408516802,0.0029389853156469,0.0407247159012733,"down","yes","LOC107131311","protein_coding","chrNC_037357.1:49885112-49941048:-","gi|194680407|ref|XP_001788041.1|",2608,0,"PREDICTED: protein BHLHb9 [Bos taurus]","gi|983010694|ref|XM_001787989.6|",4151,0,"PREDICTED: Bos taurus basic helix-loop-helix domain containing, class B, 9 (BHLHB9), transcript variant X4, mRNA","Q6PI77",701,0,"Protein BHLHb9",".",".",".",".","pfam04826","Arm_2","Armadillo-like. This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.","GO:0007611|learning or memory;GO:0043524|negative regulation of neuron apoptotic process;GO:0061003|positive regulation of dendritic spine morphogenesis;GO:0050769|positive regulation of neurogenesis;GO:0051965|positive regulation of synapse assembly;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005654|nucleoplasm;","GO:0042803|protein homodimerization activity;",".","."]
["gene3346",1255,331,292,525.236231060393,2879,1585,2184,2446.11841687243,0.214722323922466,-2.21945590397957,0.000492011070636276,0.010444618940717,"down","yes","MLLT11","protein_coding","chrNC_037330.1:19721036-19730753:-","gi|115495765|ref|NP_001069637.1|",389,{"v":9e-42,"d":"9.00E-42"},"protein AF1q [Bos taurus]","gi|942052572|ref|XM_014477995.1|",1625,0,"PREDICTED: Bos mutus myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (MLLT11), transcript variant X2, mRNA","Q0VCT1",154,{"v":3e-43,"d":"3.00E-43"},"Protein AF1q",".",".",".",".","pfam15017","AF1Q","Drug resistance and apoptosis regulator. AF1q is an oncogenic factor involved in leukaemia development, thyroid tumorigenesis, and breast cancer metastasis. AF1q plays a critical role in the regulation of apoptosis and drug resistance. Initially identified as a mixed-lineage leukaemia fusion partner (MLL11) in infant acute myelomonocytic leukemia carrying t(1;11)(q21;q23) translocation. It is located in chromosome 1 band 21. AF1Q may be a novel mediator of metastasis promotion in human breast cancer through regulation of the MMP pathway and RhoC expression.This family of proteins is found in eukaryotes. Proteins in this family are typically between 25 and 482 amino acids in length.","GO:0097191|extrinsic apoptotic signaling pathway;GO:0097193|intrinsic apoptotic signaling pathway;GO:0043065|positive regulation of apoptotic process;GO:0051901|positive regulation of mitochondrial depolarization;GO:0090200|positive regulation of release of cytochrome c from mitochondria;GO:0045893|positive regulation of transcription, DNA-templated;","GO:0005829|cytosol;GO:0005622|intracellular;GO:0005815|microtubule organizing center;GO:0005654|nucleoplasm;",".",".","."]
["gene33479",21,10,5,10.2858729336669,151,122,134,149.581832087364,0.0687641860654533,-3.86219881726756,{"v":1.58363714747046e-09,"d":"1.58E-09"},{"v":1.99923679002123e-07,"d":"2.00E-07"},"down","yes","DRP2","protein_coding","chrNC_037357.1:50912107-50955939:-","gi|741982014|ref|XP_010819967.1|",4994,0,"PREDICTED: dystrophin-related protein 2 isoform X1 [Bos taurus]","gi|982973275|ref|XM_010821665.2|",4898,0,"PREDICTED: Bos taurus dystrophin related protein 2 (DRP2), transcript variant X1, mRNA","Q13474",1750,0,"Dystrophin-related protein 2",".",".",".",".","pfam09068","EF-hand_2","EF hand. Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilisation of the WW domain (pfam00397), enhancing dystroglycan binding.","GO:0007417|central nervous system development;GO:0050808|synapse organization;","GO:0030054|cell junction;GO:0030425|dendrite;GO:0043204|perikaryon;GO:0014069|postsynaptic density;GO:0045211|postsynaptic membrane;","GO:0008270|zinc ion binding;",".","."]
["gene3408",9,8,2,5.58159383239484,65,18,39,44.9786447535039,0.124094308821077,-3.01049114238349,0.002035322120973,0.0312035332796779,"down","yes","FCGR1A","protein_coding","chrNC_037330.1:20802174-20811115:-","gi|27806975|ref|NP_776963.1|",1879,0,"high affinity immunoglobulin gamma Fc receptor I precursor [Bos taurus]","gi|86827646|gb|BC112691.1|",1419,0,"Bos taurus Fc fragment of IgG, high affinity Ia, receptor (CD64), mRNA (cDNA clone MGC:137713 IMAGE:8167137), complete cds","P12314",478,{"v":3e-165,"d":"3.00E-165"},"High affinity immunoglobulin gamma Fc receptor I",".",".",".",".","pfam13895","Ig_2","Immunoglobulin domain. This domain contains immunoglobulin-like domains.","GO:0002479|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;GO:0038096|Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0006955|immune response;GO:0060333|interferon-gamma-mediated signaling pathway;GO:0006911|phagocytosis, engulfment;GO:0006898|receptor-mediated endocytosis;GO:0050776|regulation of immune response;GO:0007165|signal transduction;","GO:0030669|clathrin-coated endocytic vesicle membrane;GO:0031901|early endosome membrane;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0019864|IgG binding;","K06498","FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I"]
["gene34166",249,131,181,163.415217631347,374,426,430,451.344312153544,0.362063314482966,-1.4656860895583,{"v":4.49708329881515e-05,"d":"4.50E-05"},0.00147140233484513,"down","yes","GK","protein_coding","chrNC_037357.1:112859360-112935548:-","gi|741983438|ref|XP_010820402.1|",2923,0,"PREDICTED: glycerol kinase isoform X1 [Bos taurus]","gi|982974437|ref|XM_010822100.2|",3967,0,"PREDICTED: Bos taurus glycerol kinase (GK), transcript variant X1, mRNA","Q0IID9",1105,0,"Glycerol kinase","Rv3696c",470,{"v":3e-150,"d":"3.00E-150"},"COG0554","pfam00370","FGGY_N","FGGY family of carbohydrate kinases, N-terminal domain. This domain adopts a ribonuclease H-like fold and is structurally related to the C-terminal domain.","GO:0019563|glycerol catabolic process;GO:0006071|glycerol metabolic process;GO:0046167|glycerol-3-phosphate biosynthetic process;GO:0006641|triglyceride metabolic process;","GO:0005741|mitochondrial outer membrane;GO:0005739|mitochondrion;","GO:0005524|ATP binding;GO:0004370|glycerol kinase activity;","K00864","glpK, GK; glycerol kinase [EC:2.7.1.30]"]
["gene34201",22,80,38,43.6217476240319,142,146,162,165.132861808138,0.264161519072529,-1.92050777321788,0.000426040696988452,0.00933591945144203,"down","yes","ARX","protein_coding","chrNC_037357.1:118321616-118334786:+","gi|426395443|ref|XP_004063982.1|",1114,{"v":2e-134,"d":"2.00E-134"},"PREDICTED: homeobox protein ARX [Gorilla gorilla gorilla]","gi|983011662|ref|XM_015470563.1|",3874,0,"PREDICTED: Bos taurus aristaless related homeobox (ARX), transcript variant X2, mRNA","Q96QS3",433,{"v":2e-135,"d":"2.00E-135"},"Homeobox protein ARX",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0007411|axon guidance;GO:0021846|cell proliferation in forebrain;GO:0021853|cerebral cortex GABAergic interneuron migration;GO:0021800|cerebral cortex tangential migration;GO:0021831|embryonic olfactory bulb interneuron precursor migration;GO:0072148|epithelial cell fate commitment;GO:0021759|globus pallidus development;GO:0044241|lipid digestion;GO:0010628|positive regulation of gene expression;GO:0046622|positive regulation of organ growth;GO:0042127|regulation of cell proliferation;GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;","GO:0003682|chromatin binding;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001206|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding;","K09452","ARX; homeobox protein aristaless-related"]
["gene34234",1114,1499,2216,1462.16462704177,2947,2715,2631,3047.58548110167,0.479778052530035,-1.05956093190022,0.000432873668596218,0.00944936391638768,"down","yes","SMS","protein_coding","chrNC_037357.1:121317041-121367225:-","gi|803271934|ref|XP_011995680.1|",2021,0,"PREDICTED: spermine synthase isoform X2 [Ovis aries musimon]","gi|78369281|ref|NM_001035471.1|",1674,0,"Bos taurus spermine synthase (SMS), mRNA","Q3SZA5",717,0,"Spermine synthase",".",".",".",".","pfam01564","Spermine_synth","Spermine/spermidine synthase. Spermine and spermidine are polyamines. This family includes spermidine synthase that catalyses the fifth (last) step in the biosynthesis of spermidine from arginine, and spermine synthase.","GO:0006597|spermine biosynthetic process;",".","GO:0016768|spermine synthase activity;","K00802","SMS; spermine synthase [EC:2.5.1.22]"]
["gene34654",0,1,0,0.327717679206592,9,23,8,14.6924100060471,0.0223052364500929,-5.48647374807128,0.00156527141184169,0.0257547627746571,"down","yes","LOC107133009","pseudogene","chrNW_020190994.1:154568-155356:+","gi|641695657|ref|XP_008160308.1|",197,{"v":1e-38,"d":"1.00E-38"},"PREDICTED: 40S ribosomal protein S23 [Eptesicus fuscus]","gi|850486327|gb|CP011895.1|",266,{"v":2e-135,"d":"2.00E-135"},"Ovis canadensis canadensis isolate 43U chromosome 10 sequence","Q9M5Z9",72.4,{"v":3e-32,"d":"3.00E-32"},"40S ribosomal protein S23","YPR132w",73.6,{"v":6e-29,"d":"6.00E-29"},"COG0048","pfam00164","Ribosom_S12_S23","Ribosomal protein S12/S23. This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.","GO:0006412|translation;","GO:0015935|small ribosomal subunit;","GO:0003735|structural constituent of ribosome;",".","."]
["gene35104",1,0,2,0.874866504052415,51,162,99,114.25047473259,0.0076574430530822,-7.02892155184097,{"v":1.6280426106779e-11,"d":"1.63E-11"},{"v":3.09664558168341e-09,"d":"3.10E-09"},"down","yes","LOC112445823","protein_coding","chrNW_020192292.1:7360373-7371888:-","gi|511908547|ref|XP_004773706.1|",2213,0,"PREDICTED: zinc finger protein ZIC 3 isoform X3 [Mustela putorius furo]","gi|965855203|ref|XM_012142142.2|",3515,0,"PREDICTED: Ovis aries musimon Zic family member 3 (ZIC3), transcript variant X2, mRNA","O60481",803,0,"Zinc finger protein ZIC 3",".",".",".",".","pfam13465","zf-H2C2_2","Zinc-finger double domain.","GO:0009952|anterior/posterior pattern specification;GO:0030154|cell differentiation;GO:0071907|determination of digestive tract left/right asymmetry;GO:0035545|determination of left/right asymmetry in nervous system;GO:0007368|determination of left/right symmetry;GO:0071910|determination of liver left/right asymmetry;GO:0035469|determination of pancreatic left/right asymmetry;GO:0001947|heart looping;GO:0030324|lung development;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0035019|somatic stem cell population maintenance;","GO:0005737|cytoplasm;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K18487","ZIC3; zinc finger protein ZIC 3"]
["gene3513",48,32,62,42.0384223864514,144,116,147,149.456177592025,0.281275910194926,-1.82994209620038,0.000229062011189395,0.00560494703365748,"down","yes","ANKRD35","protein_coding","chrNC_037330.1:21481300-21498221:+","gi|300798045|ref|NP_001179306.1|",4062,0,"ankyrin repeat domain-containing protein 35 [Bos taurus]","gi|982916756|ref|XR_233898.3|",3604,0,"PREDICTED: Bos taurus ankyrin repeat domain 35 (ANKRD35), transcript variant X1, misc_RNA",".",".",".",".","all2748",106,{"v":2e-23,"d":"2.00E-23"},"COG0666","pfam12796","Ank_2","Ankyrin repeats (3 copies).",".",".",".",".","."]
["gene3517",1205,949,1208,996.058011353277,7430,2188,5439,5543.39725131978,0.179683678833613,-2.47646872407607,{"v":4.93907434761711e-08,"d":"4.94E-08"},{"v":4.47354699085282e-06,"d":"4.47E-06"},"down","yes","RNF115","protein_coding","chrNC_037330.1:21532873-21599284:+","gi|528942981|ref|XP_005204053.1|",1393,0,"PREDICTED: E3 ubiquitin-protein ligase RNF115 isoform X1 [Bos taurus]","gi|982916767|ref|XM_005203996.2|",2007,0,"PREDICTED: Bos taurus ring finger protein 115 (RNF115), transcript variant X1, mRNA","Q9D0C1",426,{"v":1e-141,"d":"1.00E-141"},"E3 ubiquitin-protein ligase RNF115",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0042059|negative regulation of epidermal growth factor receptor signaling pathway;GO:0043161|proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051865|protein autoubiquitination;GO:0070936|protein K48-linked ubiquitination;GO:0070534|protein K63-linked ubiquitination;GO:0043162|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;","GO:0005829|cytosol;","GO:0046872|metal ion binding;GO:0061630|ubiquitin protein ligase activity;GO:0004842|ubiquitin-protein transferase activity;","K11982","RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]"]
["gene3519",4,1,0,1.37021062655144,12,34,15,22.3773877546583,0.0612319293732666,-4.0295720477022,0.00180812538343496,0.0286279829715775,"down","yes","PDZK1","protein_coding","chrNC_037330.1:21648117-21695753:+","gi|77736169|ref|NP_001029783.1|",1554,0,"Na(+)/H(+) exchange regulatory cofactor NHE-RF3 [Bos taurus]","gi|982916760|ref|XM_005203990.3|",1394,0,"PREDICTED: Bos taurus PDZ domain containing 1 (PDZK1), transcript variant X2, mRNA","Q3T0X8",603,0,"Na(+)/H(+) exchange regulatory cofactor NHE-RF3",".",".",".",".","pfam00595","PDZ","PDZ domain (Also known as DHR or GLGF). PDZ domains are found in diverse signaling proteins.","GO:0015879|carnitine transport;GO:1904064|positive regulation of cation transmembrane transport;GO:0032414|positive regulation of ion transmembrane transporter activity;GO:0090314|positive regulation of protein targeting to membrane;GO:0044070|regulation of anion transport;","GO:0031526|brush border membrane;GO:0005886|plasma membrane;","GO:0030165|PDZ domain binding;",".","."]
["gene3571",0,0,0,0,0,52,28,29.1905944641419,{"$error":"#NAME?"},{"$error":"#NAME?"},{"v":1.28035859770916e-05,"d":"1.28E-05"},0.000527888889468786,"down","yes","HAO2","protein_coding","chrNC_037330.1:23720165-23764186:-","gi|78050047|ref|NP_001030243.1|",1763,0,"hydroxyacid oxidase 2 [Bos taurus]","gi|742154973|ref|XM_010847214.1|",1244,0,"PREDICTED: Bison bison bison 3 beta-hydroxysteroid dehydrogenase/Delta 5-->gi|742154975|ref|XM_010847215.1| PREDICTED: Bison bison bison hydroxyacid oxidase 2 (long chain) (HAO2), transcript variant X1, mRNA","Q3ZBW2",681,0,"Hydroxyacid oxidase 2","all0170",257,{"v":8e-74,"d":"8.00E-74"},"COG1304","pfam01070","FMN_dh","FMN-dependent dehydrogenase.","GO:0019395|fatty acid oxidation;","GO:0005777|peroxisome;","GO:0010181|FMN binding;GO:0052853|long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity;GO:0052854|medium-chain-(S)-2-hydroxy-acid oxidase activity;GO:0005102|receptor binding;GO:0052852|very-long-chain-(S)-2-hydroxy-acid oxidase activity;","K11517","HAO; (S)-2-hydroxy-acid oxidase [EC:1.1.3.15]"]
["gene3692",20,3,7,8.34546920960072,54,63,43,58.8255279198081,0.141868156644125,-2.81737729271253,0.000477791746709656,0.0102187978451073,"down","yes","DENND2D","protein_coding","chrNC_037330.1:32204972-32226348:+","gi|528943226|ref|XP_005204146.1|",2281,0,"PREDICTED: DENN domain-containing protein 2D isoform X1 [Bos taurus]","gi|942093952|ref|XM_005908560.2|",3475,0,"PREDICTED: Bos mutus DENN/MADD domain containing 2D (DENND2D), mRNA","Q9H6A0",790,0,"DENN domain-containing protein 2D",".",".",".",".","pfam02141","DENN","DENN (AEX-3) domain. DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.",".","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0017112|Rab guanyl-nucleotide exchange factor activity;",".","."]
["gene3721",601,554,566,512.0210042412,1672,692,1327,1357.90666750727,0.377066418843884,-1.40710942365644,0.00120312150383416,0.020930646113349,"down","yes","GSTM3","protein_coding","chrNC_037330.1:33652523-33655762:+","gi|114053087|ref|NP_001040025.1|",1215,{"v":6e-167,"d":"6.00E-167"},"glutathione S-transferase Mu 3 [Bos taurus]","gi|942042299|ref|XM_005891293.2|",804,0,"PREDICTED: Bos mutus glutathione S-transferase mu 3 (brain) (GSTM3), mRNA","Q9Z1B2",435,{"v":9e-154,"d":"9.00E-154"},"Glutathione S-transferase Mu 5",".",".",".",".","pfam00043","GST_C","Glutathione S-transferase, C-terminal domain. GST conjugates reduced glutathione to a variety of targets including S-crystallin from squid, the eukaryotic elongation factor 1-gamma, the HSP26 family of stress-related proteins and auxin-regulated proteins in plants. Stringent starvation proteins in Escherichia coli are also included in the alignment but are not known to have GST activity.     The glutathione molecule binds in a cleft between N and C-terminal domains. The catalytically important residues are proposed to reside in the N-terminal domain. In plants, GSTs are encoded by a large gene family (48 GST genes in Arabidopsis) and can be divided into the phi, tau, theta, zeta, and lambda classes.","GO:0006749|glutathione metabolic process;","GO:0005737|cytoplasm;","GO:0004364|glutathione transferase activity;GO:0042803|protein homodimerization activity;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["gene3724",215,268,261,224.021080318867,671,459,532,611.283259337337,0.366476714186018,-1.44820656200063,{"v":2.84080001004162e-05,"d":"2.84E-05"},0.00101187097486264,"down","yes","GSTM2","protein_coding","chrNC_037330.1:33706059-33720165:-","gi|148744125|gb|AAI42537.1|",1221,{"v":2e-152,"d":"2.00E-152"},"GSTM2 protein [Bos taurus]","gi|982978921|ref|XM_005197782.3|",1706,0,"PREDICTED: Bos taurus glutathione S-transferase M2 (GSTM2), mRNA","Q9N0V4",445,{"v":2e-143,"d":"2.00E-143"},"Glutathione S-transferase Mu 1",".",".",".",".","pfam02798","GST_N","Glutathione S-transferase, N-terminal domain. Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but are not GSTs: * S-crystallins from squid. Similarity to GST previously noted. * Eukaryotic elongation factors 1-gamma. Not known to have GST activity; similarity not previously recognized. * HSP26 family of stress-related proteins. including auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. Not known to have GST activity. Similarity not previously recognized. The glutathione molecule binds in a cleft between N and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain.","GO:0008152|metabolic process;","GO:0005737|cytoplasm;","GO:0004364|glutathione transferase activity;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["gene3823",4403,2102,5819,3623.52745944764,27040,12827,22273,22853.9878505459,0.158551211418495,-2.65697919441956,{"v":1.1311651568997e-06,"d":"1.13E-06"},{"v":6.79437328242218e-05,"d":"6.79E-05"},"down","yes","PALMD","protein_coding","chrNC_037330.1:43536425-43596104:-","gi|296489340|tpg|DAA31453.1|",2641,0,"TPA: palmdelphin [Bos taurus]","gi|402746468|ref|NM_001035079.2|",2107,0,"Bos taurus palmdelphin (PALMD), mRNA","Q3MHH7",1015,0,"Palmdelphin",".",".",".",".","pfam03285","Paralemmin","Paralemmin.","GO:0008360|regulation of cell shape;","GO:0005737|cytoplasm;GO:0043197|dendritic spine;GO:0016020|membrane;",".","K16519","AKAP2; A-kinase anchor protein 2"]
["gene3998",0,0,0,0,1,47,9,20.8709398287679,{"$error":"#NAME?"},{"$error":"#NAME?"},0.000157267756611582,0.00422268842172665,"down","yes","UOX","protein_coding","chrNC_037330.1:59700670-59736411:+","gi|742204047|ref|XP_010858603.1|",1717,0,"PREDICTED: uricase [Bison bison bison]","gi|402743756|ref|NM_001075648.2|",1868,0,"Bos taurus urate oxidase (UOX), mRNA","Q3MHG7",637,0,"Uricase","SPCC1223.09",156,{"v":7e-42,"d":"7.00E-42"},"COG3648","pfam01014","Uricase","Uricase.","GO:0006144|purine nucleobase metabolic process;GO:0019628|urate catabolic process;","GO:0005777|peroxisome;","GO:0004846|urate oxidase activity;","K00365","uaZ; urate oxidase [EC:1.7.3.3]"]
["gene4029",3293,1760,2599,2233.2245600527,9311,4449,7104,7677.23378171732,0.290889221762522,-1.78145825323716,{"v":3.74352000414955e-05,"d":"3.74E-05"},0.00127301989557081,"down","yes","NEXN","protein_coding","chrNC_037330.1:66740716-66798062:-","gi|594090167|ref|XP_006068496.1|",2024,0,"PREDICTED: nexilin isoform X1 [Bubalus bubalis]","gi|982979236|ref|XM_015462717.1|",3361,0,"PREDICTED: Bos taurus nexilin (F actin binding protein) (NEXN), transcript variant X1, mRNA","Q0ZGT2",719,0,"Nexilin",".",".",".",".","pfam07679","I-set","Immunoglobulin I-set domain.","GO:0048739|cardiac muscle fiber development;GO:0030334|regulation of cell migration;GO:0051493|regulation of cytoskeleton organization;","GO:0005856|cytoskeleton;GO:0005925|focal adhesion;GO:0030018|Z disc;","GO:0051015|actin filament binding;GO:0008307|structural constituent of muscle;",".","."]
["gene4070",20,36,58,34.8233559374314,640,322,569,562.775148462821,0.0618779205736942,-4.01443147437798,{"v":3.29039265952401e-10,"d":"3.29E-10"},{"v":4.96710015708357e-08,"d":"4.97E-08"},"down","yes","PTGER3","protein_coding","chrNC_037330.1:74185627-74414286:+","gi|528944116|ref|XP_005204497.1|",1932,0,"PREDICTED: prostaglandin E2 receptor EP3 subtype isoform X1 [Bos taurus]","gi|742160245|ref|XM_010848752.1|",2195,0,"PREDICTED: Bison bison bison prostaglandin E receptor 3 (subtype EP3) (PTGER3), transcript variant X5, mRNA","P34979",687,0,"Prostaglandin E2 receptor EP3 subtype",".",".",".",".","pfam00001","7tm_1","7 transmembrane receptor (rhodopsin family). This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.","GO:0014827|intestine smooth muscle contraction;GO:0060455|negative regulation of gastric acid secretion;GO:0007200|phospholipase C-activating G-protein coupled receptor signaling pathway;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0004957|prostaglandin E receptor activity;","K04260","PTGER3; prostaglandin E receptor 3"]
["gene4083",3,0,2,1.39611297772484,21,24,17,22.7933706533343,0.061250834681645,-4.0291266855311,0.00138377515423932,0.0234027794461185,"down","yes","DIRAS3","protein_coding","chrNC_037330.1:77225725-77249258:+","gi|77735389|ref|NP_001029387.1|",1125,{"v":4e-141,"d":"4.00E-141"},"GTP-binding protein Di-Ras3 [Bos taurus]","gi|982919545|ref|XM_015465020.1|",1603,0,"PREDICTED: Bos taurus DIRAS family, GTP-binding RAS-like 3 (DIRAS3), transcript variant X1, mRNA","O95661",230,{"v":9e-67,"d":"9.00E-67"},"GTP-binding protein Di-Ras3",".",".",".",".","pfam00071","Ras","Ras family. Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See pfam00009 pfam00025, pfam00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices.","GO:0000079|regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0006349|regulation of gene expression by genetic imprinting;GO:0007264|small GTPase mediated signal transduction;","GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0005525|GTP binding;GO:0003924|GTPase activity;","K07842","DIRAS3, NOEY2; DIRAS family, GTP-binding Ras-like 3"]
["gene4105",117,95,14,65.9258011049764,172,317,211,256.788450345088,0.256731955881899,-1.96166521298654,0.00142905592172486,0.023955578438738,"down","yes","LEPR","protein_coding","chrNC_037330.1:79741204-79838014:-","gi|296489163|tpg|DAA31276.1|",4649,0,"TPA: leptin receptor [Bos taurus]","gi|982919541|ref|XM_010803431.2|",5197,0,"PREDICTED: Bos taurus leptin receptor (LEPR), transcript variant X1, mRNA","O02671",1585,0,"Leptin receptor",".",".",".",".","pfam06328","Lep_receptor_Ig","Ig-like C2-type domain. This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.","GO:0001525|angiogenesis;GO:0097009|energy homeostasis;GO:0042593|glucose homeostasis;GO:0033210|leptin-mediated signaling pathway;GO:0010507|negative regulation of autophagy;GO:0006909|phagocytosis;GO:0046850|regulation of bone remodeling;GO:0060259|regulation of feeding behavior;GO:0044321|response to leptin;GO:0019953|sexual reproduction;GO:0030217|T cell differentiation;","GO:0016323|basolateral plasma membrane;GO:0016021|integral component of membrane;","GO:0038021|leptin receptor activity;","K05062","LEPR; leptin receptor"]
["gene4223",211,312,278,242.61923302795,576,351,488,520.25782622697,0.466344225491965,-1.10053284155002,0.00337442796082871,0.0450307783678223,"down","yes","LRRC42","protein_coding","chrNC_037330.1:92241257-92262228:-","gi|594087601|ref|XP_006067274.1|",2315,0,"PREDICTED: leucine-rich repeat-containing protein 42 isoform X1 [Bubalus bubalis]","gi|114052025|ref|NM_001046386.1|",1599,0,"Bos taurus leucine rich repeat containing 42 (LRRC42), mRNA",".",".",".",".",".",".",".",".","pfam12799","LRR_4","Leucine Rich repeats (2 copies). Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.",".",".",".",".","."]
["gene4267",30,30,24,25.0211466878785,259,37,153,165.61332734384,0.151081722039981,-2.72659896196445,0.000127643793539022,0.00355992675802721,"down","yes","TTC39A","protein_coding","chrNC_037330.1:94953378-95004042:+","gi|555965451|ref|XP_005894783.1|",2911,0,"PREDICTED: tetratricopeptide repeat protein 39A [Bos mutus]","gi|982979448|ref|XM_015462775.1|",2572,0,"PREDICTED: Bos taurus tetratricopeptide repeat domain 39A (TTC39A), transcript variant X1, mRNA",".",".",".",".",".",".",".",".","pfam10300","DUF3808","Protein of unknown function (DUF3808). This is a family of proteins conserved from fungi to humans. Members of this family also carry a TPR_2 domain pfam07719 at their C-terminus.",".",".",".",".","."]
["gene4362",331,565,553,441.265043529791,1039,658,862,940.981495943843,0.468941254883215,-1.09252088983735,0.00181416742693919,0.0286682115913327,"down","yes","EIF2B3","protein_coding","chrNC_037330.1:101059252-101173087:+","gi|134085779|ref|NP_001076943.1|",2323,0,"translation initiation factor eIF-2B subunit gamma [Bos taurus]","gi|134085778|ref|NM_001083474.1|",1534,0,"Bos taurus eukaryotic translation initiation factor 2B subunit gamma (EIF2B3), mRNA","A5PJI7",896,0,"Translation initiation factor eIF-2B subunit gamma","SPAC4D7.09",210,{"v":3e-60,"d":"3.00E-60"},"COG1208","pfam00483","NTP_transferase","Nucleotidyl transferase. This family includes a wide range of enzymes which transfer nucleotides onto phosphosugars.","GO:0014003|oligodendrocyte development;GO:0050852|T cell receptor signaling pathway;GO:0006413|translational initiation;","GO:0005737|cytoplasm;GO:0005851|eukaryotic translation initiation factor 2B complex;","GO:0016779|nucleotidyltransferase activity;GO:0003743|translation initiation factor activity;",".","."]
["gene4364",23,10,24,16.6424304458932,58,96,87,88.3139971491419,0.188446123866276,-2.40777597426244,0.00015732774148454,0.00422268842172665,"down","yes","PTCH2","protein_coding","chrNC_037330.1:101178957-101194939:+","gi|528902519|ref|XP_005197961.1|",5470,0,"PREDICTED: protein patched homolog 2 isoform X1 [Bos taurus]","gi|982979532|ref|XM_005197904.3|",4469,0,"PREDICTED: Bos taurus patched 2 (PTCH2), transcript variant X1, mRNA","Q9Y6C5",1976,0,"Protein patched homolog 2",".",".",".",".","pfam12349","Sterol-sensing","Sterol-sensing domain of SREBP cleavage-activation. Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.","GO:0001709|cell fate determination;GO:0009957|epidermal cell fate specification;GO:0042633|hair cycle;GO:0045879|negative regulation of smoothened signaling pathway;GO:0045606|positive regulation of epidermal cell differentiation;GO:0043588|skin development;","GO:0016021|integral component of membrane;","GO:0097108|hedgehog family protein binding;GO:0008158|hedgehog receptor activity;GO:0005119|smoothened binding;","K11101","PTCH2; patched 2"]
["gene4439",77,63,215,106.745354252145,1020,329,792,787.872889841076,0.135485502329794,-2.88378961110095,0.000855339123362766,0.0160339556692924,"down","yes","SLC2A1","protein_coding","chrNC_037330.1:103309108-103337308:+","gi|27807089|ref|NP_777027.1|",2447,0,"solute carrier family 2, facilitated glucose transporter member 1 [Bos taurus]","gi|31341556|ref|NM_174602.2|",2511,0,"Bos taurus solute carrier family 2 (facilitated glucose transporter), member 1 (SLC2A1), mRNA","P27674",947,0,"Solute carrier family 2, facilitated glucose transporter member 1","YBR241c",200,{"v":6e-55,"d":"6.00E-55"},"COG0477","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0042149|cellular response to glucose starvation;GO:0046323|glucose import;GO:1904659|glucose transmembrane transport;GO:0065003|macromolecular complex assembly;","GO:0016324|apical plasma membrane;GO:0016323|basolateral plasma membrane;GO:0030864|cortical actin cytoskeleton;GO:0005829|cytosol;GO:0001939|female pronucleus;GO:0005887|integral component of plasma membrane;GO:0042470|melanosome;GO:0045121|membrane raft;GO:0030496|midbody;","GO:0055056|D-glucose transmembrane transporter activity;GO:0033300|dehydroascorbic acid transporter activity;GO:0005355|glucose transmembrane transporter activity;GO:0042802|identical protein binding;GO:0043621|protein self-association;","K07299","SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1"]
["gene4498",0,0,1,0.307121633608102,35,1,8,16.3366538330863,0.0187995434527782,-5.73315856331917,0.00225938269201634,0.0335916871213748,"down","yes","BMP8B","protein_coding","chrNC_037330.1:106294530-106326378:+","gi|332309231|ref|NP_001193798.1|",1535,0,"bone morphogenetic protein 8A precursor [Bos taurus]","gi|982979763|ref|XM_015462841.1|",2830,0,"PREDICTED: Bos taurus bone morphogenetic protein 8b (BMP8B), mRNA","P34820",539,{"v":2e-180,"d":"2.00E-180"},"Bone morphogenetic protein 8B",".",".",".",".","pfam00019","TGF_beta","Transforming growth factor beta like domain.","GO:0030509|BMP signaling pathway;GO:0051216|cartilage development;GO:0048468|cell development;GO:0001503|ossification;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0042981|regulation of apoptotic process;GO:0043408|regulation of MAPK cascade;GO:0001501|skeletal system development;GO:0060395|SMAD protein signal transduction;","GO:0005615|extracellular space;","GO:0070700|BMP receptor binding;GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0005160|transforming growth factor beta receptor binding;","K16622","BMP8; bone morphogenetic protein 8"]
["gene473",218,79,123,120.481523221411,311,197,283,290.693754570687,0.414462028602385,-1.27068816121549,0.00133239839965576,0.022736039916614,"down","yes","HACD2","protein_coding","chrNC_037328.1:67866129-67952692:-","gi|440907969|gb|ELR58045.1|",1256,{"v":2e-171,"d":"2.00E-171"},"3-hydroxyacyl-CoA dehydratase 2, partial [Bos mutus]","gi|402746491|ref|NM_001130757.2|",979,0,"Bos taurus 3-hydroxyacyl-CoA dehydratase 2 (HACD2), mRNA","Q2KIP8",458,{"v":2e-161,"d":"2.00E-161"},"Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2","YJL097w",105,{"v":1e-25,"d":"1.00E-25"},"COG5198","pfam04387","PTPLA","Protein tyrosine phosphatase-like protein, PTPLA. This family includes the mammalian protein tyrosine phosphatase-like protein, PTPLA. A significant variation of PTPLA from other protein tyrosine phosphatases is the presence of proline instead of catalytic arginine at the active site. It is thought that PTPLA proteins have a role in the development, differentiation, and maintenance of a number of tissue types.","GO:0030497|fatty acid elongation;GO:0030148|sphingolipid biosynthetic process;GO:0042761|very long-chain fatty acid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0018812|3-hydroxyacyl-CoA dehydratase activity;GO:0019899|enzyme binding;","K10703","PHS1, PAS2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [EC:4.2.1.134]"]
["gene4740",37,26,8,20.620692491176,117,88,119,118.981546348638,0.17331000582858,-2.52857314585631,{"v":1.71321082911075e-05,"d":"1.71E-05"},0.000668667827159489,"down","yes","KIF1A","protein_coding","chrNC_037330.1:120040002-120127960:-","gi|741922678|ref|XP_010802225.1|",8964,0,"PREDICTED: kinesin-like protein KIF1A isoform X1 [Bos taurus]","gi|982979966|ref|XM_015462883.1|",8383,0,"PREDICTED: Bos taurus kinesin family member 1A (KIF1A), transcript variant X1, mRNA","O60333",2373,0,"Kinesin-like protein KIF1B","SPAC1834.07",223,{"v":5e-60,"d":"5.00E-60"},"COG5059","pfam00225","Kinesin","Kinesin motor domain.","GO:0008089|anterograde axon cargo transport;GO:1990048|anterograde dense core granule transport;GO:0006915|apoptotic process;GO:1990090|cellular response to nerve growth factor stimulus;GO:0030705|cytoskeleton-dependent intracellular transport;GO:0032418|lysosome localization;GO:0007018|microtubule-based movement;GO:0047497|mitochondrion transport along microtubule;GO:0007274|neuromuscular synaptic transmission;GO:0007270|neuron-neuron synaptic transmission;GO:0010628|positive regulation of gene expression;GO:1990778|protein localization to cell periphery;GO:1904647|response to rotenone;GO:1990049|retrograde dense core granule transport;","GO:1904115|axon cytoplasm;GO:0031410|cytoplasmic vesicle;GO:0030659|cytoplasmic vesicle membrane;GO:0005871|kinesin complex;GO:0005874|microtubule;GO:0005875|microtubule associated complex;GO:0005739|mitochondrion;GO:0043005|neuron projection;","GO:0005524|ATP binding;GO:0016887|ATPase activity;GO:0019900|kinase binding;GO:0019894|kinesin binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0097110|scaffold protein binding;","K10392","KIF1; kinesin family member 1"]
["gene4863",63,30,25,33.9288351370816,100,78,103,103.182046910349,0.328824986061393,-1.60460816722638,0.00348447573803253,0.0460962093587537,"down","yes","DYNC1I1","protein_coding","chrNC_037331.1:13061908-13441077:+","gi|528945936|ref|XP_005205220.1|",3161,0,"PREDICTED: cytoplasmic dynein 1 intermediate chain 1 isoform X2 [Bos taurus]","gi|982920930|ref|XM_005205163.3|",2626,0,"PREDICTED: Bos taurus dynein, cytoplasmic 1, intermediate chain 1 (DYNC1I1), transcript variant X5, mRNA","O88485",1193,0,"Cytoplasmic dynein 1 intermediate chain 1",".",".",".",".","pfam11540","Dynein_IC2","Cytoplasmic dynein 1 intermediate chain 2. Intermediate chain IC 2 forms part of the complex cytoplasmic dynein 1 along with a heavy chain (HC), two light intermediate chains (LICs) and three light chains (LCs). The complex is responsible for hydrolysing ATP to generate force toward the minus end of microtubules. IC binds to the HC via the N terminal binding domain on the HC and ICs contain binding sites for the LCs. The ICs are responsible for binding to kinetochores and the Golgi apparatus through an interaction with the p150Glued subunit of dynactin which is another complex.","GO:2000582|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed;GO:0010970|microtubule-based transport;GO:0047496|vesicle transport along microtubule;","GO:1904115|axon cytoplasm;GO:0000777|condensed chromosome kinetochore;GO:0005737|cytoplasm;GO:0005868|cytoplasmic dynein complex;GO:0036464|cytoplasmic ribonucleoprotein granule;GO:0000776|kinetochore;GO:0005874|microtubule;GO:0005634|nucleus;GO:0048471|perinuclear region of cytoplasm;GO:0055037|recycling endosome;GO:0000922|spindle pole;GO:0031982|vesicle;","GO:0045504|dynein heavy chain binding;GO:0045503|dynein light chain binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0030507|spectrin binding;","K10415","DYNC1I, DNCI; dynein intermediate chain, cytosolic"]
["gene4949",897,528,820,658.653717621806,1898,909,1500,1584.46286806218,0.41569526866057,-1.26640176722523,0.00253085117672,0.036413371115985,"down","yes","HDAC9","protein_coding","chrNC_037331.1:26624494-27670033:+","gi|528903160|ref|XP_005198073.1|",5011,0,"PREDICTED: histone deacetylase 9 isoform X1 [Bos taurus]","gi|742099675|ref|XM_010835591.1|",5376,0,"PREDICTED: Bison bison bison histone deacetylase 9 (HDAC9), transcript variant X2, mRNA","Q9UKV0",1699,0,"Histone deacetylase 9","SPBC800.03",265,{"v":8e-74,"d":"8.00E-74"},"COG0123","pfam00850","Hist_deacetyl","Histone deacetylase domain. Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyse the removal of the acetyl group. Histone deacetylases are related to other proteins.","GO:0042113|B cell activation;GO:0030183|B cell differentiation;GO:0032869|cellular response to insulin stimulus;GO:0007507|heart development;GO:0016575|histone deacetylation;GO:0070932|histone H3 deacetylation;GO:0070933|histone H4 deacetylation;GO:0006954|inflammatory response;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0030182|neuron differentiation;GO:0034983|peptidyl-lysine deacetylation;GO:0090050|positive regulation of cell migration involved in sprouting angiogenesis;GO:0048742|regulation of skeletal muscle fiber development;GO:0051153|regulation of striated muscle cell differentiation;GO:0001975|response to amphetamine;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0000118|histone deacetylase complex;GO:0035097|histone methyltransferase complex;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0004407|histone deacetylase activity;GO:0042826|histone deacetylase binding;GO:0046872|metal ion binding;GO:0032041|NAD-dependent histone deacetylase activity (H3-K14 specific);GO:0033558|protein deacetylase activity;GO:0005080|protein kinase C binding;GO:0070491|repressing transcription factor binding;GO:0003714|transcription corepressor activity;GO:0008134|transcription factor binding;","K11409","HDAC9; histone deacetylase 9 [EC:3.5.1.98]"]
["gene4970",62,214,197,146.793185854852,441,318,416,431.698496306726,0.340036361281541,-1.55623906783118,0.000114284592814229,0.00323477551347498,"down","yes","LOC104968411","protein_coding","chrNC_037331.1:30335238-30693652:+","gi|672021259|ref|XP_008774566.1|",18158,0,"PREDICTED: dynein heavy chain 11, axonemal isoform X3 [Rattus norvegicus]","gi|742114471|ref|XM_010839026.1|",8857,0,"PREDICTED: Bison bison bison dynein, axonemal, heavy chain 11 (DNAH11), mRNA","Q96DT5",5319,0,"Dynein heavy chain 11, axonemal","YKR054c",555,{"v":2e-157,"d":"2.00E-157"},"COG5245","pfam03028","Dynein_heavy","Dynein heavy chain and region D6 of dynein motor. This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.","GO:0035545|determination of left/right asymmetry in nervous system;GO:0007368|determination of left/right symmetry;GO:0060287|epithelial cilium movement involved in determination of left/right asymmetry;GO:0030317|sperm motility;GO:0007507|heart development;GO:0007611|learning or memory;GO:0003356|regulation of cilium beat frequency;","GO:0005930|axoneme;GO:0030286|dynein complex;GO:0005874|microtubule;GO:0031514|motile cilium;","GO:0005524|ATP binding;GO:0008569|ATP-dependent microtubule motor activity, minus-end-directed;GO:0045505|dynein intermediate chain binding;GO:0045503|dynein light chain binding;GO:0051959|dynein light intermediate chain binding;","K10408","DNAH; dynein heavy chain, axonemal"]
["gene501",392,315,244,280.333056390248,687,464,574,634.259347940278,0.441984903022106,-1.17793100288855,0.000469002422122598,0.0100534245721862,"down","yes","RUBCN","protein_coding","chrNC_037328.1:70384566-70435634:+","gi|741913745|ref|XP_010799470.1|",4478,0,"PREDICTED: run domain Beclin-1 interacting and cysteine-rich containing protein isoform X2 [Bos taurus]","gi|982910394|ref|XM_010801168.2|",5802,0,"PREDICTED: Bos taurus RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein (RUBCN), transcript variant X2, mRNA","Q92622",1504,0,"Run domain Beclin-1-interacting and cysteine-rich domain-containing protein",".",".",".",".","pfam13901","DUF4206","Domain of unknown function (DUF4206). This is a family of cysteine-rich proteins. Many members also carry a pleckstrin-homology domain, pfam00169","GO:0006914|autophagy;GO:0002376|immune system process;GO:0071985|multivesicular body sorting pathway;GO:1901097|negative regulation of autophagosome maturation;GO:0010507|negative regulation of autophagy;GO:0045806|negative regulation of endocytosis;GO:0043553|negative regulation of phosphatidylinositol 3-kinase activity;GO:0006909|phagocytosis;","GO:0005829|cytosol;GO:0005769|early endosome;GO:0043231|intracellular membrane-bounded organelle;GO:0005770|late endosome;GO:0005764|lysosome;GO:0005654|nucleoplasm;",".","K19330","KIAA0226; run domain Beclin-1 interacting and cysteine-rich containing protein"]
["gene5126",17,25,106,45.1784301688392,1492,325,1019,1044.76432381127,0.0432426999459836,-4.53139958628874,0.000579319999592603,0.0118569432628239,"down","yes","NRCAM","protein_coding","chrNC_037331.1:49242859-49563285:-","gi|296488521|tpg|DAA30634.1|",6756,0,"TPA: neuronal cell adhesion molecule isoform 1 [Bos taurus]","gi|982921517|ref|XM_005205427.3|",6264,0,"PREDICTED: Bos taurus neuronal cell adhesion molecule (NRCAM), transcript variant X12, mRNA","Q92823",2460,0,"Neuronal cell adhesion molecule",".",".",".",".","pfam13882","Bravo_FIGEY","Bravo-like intracellular region. This is the very C-terminal intracellular region of neural adhesion molecule L1 proteins that are also known as Bravo or NrCAM. It lies upstream of the IG and Fn3 domains and has the highly conserved motif FIGEY. The function is not known.","GO:0001525|angiogenesis;GO:0007413|axonal fasciculation;GO:0007409|axonogenesis;GO:0098609|cell-cell adhesion;GO:0007417|central nervous system development;GO:0045162|clustering of voltage-gated sodium channels;GO:0001764|neuron migration;GO:0019227|neuronal action potential propagation;GO:0045666|positive regulation of neuron differentiation;GO:0008104|protein localization;GO:0030516|regulation of axon extension;GO:0031290|retinal ganglion cell axon guidance;GO:0007416|synapse assembly;","GO:0043194|axon initial segment;GO:0009897|external side of plasma membrane;GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0043005|neuron projection;GO:0005886|plasma membrane;GO:0045202|synapse;","GO:0030506|ankyrin binding;GO:0086080|protein binding involved in heterotypic cell-cell adhesion;","K06756","NRCAM; neuronal cell adhesion molecule"]
["gene5235",74,23,65,46.7865323321579,402,61,312,285.264555160091,0.164011025855985,-2.60813528972048,{"v":3.50575871143899e-05,"d":"3.51E-05"},0.0011964449975606,"down","yes","ADCYAP1R1","protein_coding","chrNC_037331.1:65269927-65377140:-","gi|28372487|ref|NP_783646.1|",2586,0,"pituitary adenylate cyclase-activating polypeptide type I receptor precursor [Bos taurus]","gi|741923873|ref|XM_010804296.1|",5605,0,"PREDICTED: Bos taurus adenylate cyclase activating polypeptide 1 (pituitary) receptor type I (ADCYAP1R1), transcript variant X1, mRNA","Q29627",999,0,"Pituitary adenylate cyclase-activating polypeptide type I receptor",".",".",".",".","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007166|cell surface receptor signaling pathway;","GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0005886|plasma membrane;GO:0043235|receptor complex;","GO:0004999|vasoactive intestinal polypeptide receptor activity;","K04587","ADCYAP1R1, PACAPRI; pituitary adenylate cyclase-activating polypeptide type I receptor"]
["gene5251",732,708,646,621.200901553207,1962,1592,1816,1973.10396820502,0.314834348094859,-1.66733514895021,{"v":3.89465026629858e-08,"d":"3.89E-08"},{"v":3.64322186058245e-06,"d":"3.64E-06"},"down","yes","MTURN","protein_coding","chrNC_037331.1:66180972-66213782:-","gi|478489090|ref|XP_004418925.1|",659,{"v":9e-76,"d":"9.00E-76"},"PREDICTED: maturin [Ceratotherium simum simum]","gi|155372210|ref|NM_001101246.1|",5729,0,"Bos taurus maturin, neural progenitor differentiation regulator homolog (Xenopus) (MTURN), mRNA","Q8N3F0",258,{"v":3e-77,"d":"3.00E-77"},"Maturin",".",".",".",".","pfam15167","DUF4581","Domain of unknown function (DUF4581). This family of proteins is found in eukaryotes. Proteins in this family are typically 131 amino acids in length.","GO:0007275|multicellular organismal development;",".",".",".","."]
["gene5254",146,58,60,75.4859159885553,157,178,212,200.531629791235,0.376428975654067,-1.40955041096678,0.00123404054882852,0.021377298663404,"down","yes","SCRN1","protein_coding","chrNC_037331.1:66355082-66421251:+","gi|741923887|ref|XP_010802602.1|",2190,0,"PREDICTED: secernin-1 isoform X1 [Bos taurus]","gi|160837848|ref|NM_001110803.1|",5298,0,"Bos taurus secernin 1 (SCRN1), mRNA","P83939",848,0,"Secernin-1","PA4677",192,{"v":3e-51,"d":"3.00E-51"},"COG4690","pfam03577","Peptidase_C69","Peptidase family C69.","GO:0006887|exocytosis;","GO:0005737|cytoplasm;GO:0031965|nuclear membrane;","GO:0016805|dipeptidase activity;",".","."]
["gene5295",49,51,62,48.5256815282128,291,161,244,255.928897633693,0.18960610535535,-2.39892267482801,{"v":1.79602370625343e-06,"d":"1.80E-06"},0.000100278576053066,"down","yes","SNX10","protein_coding","chrNC_037331.1:69587802-69655624:-","gi|115496099|ref|NP_001068843.1|",836,{"v":1e-102,"d":"1.00E-102"},"sorting nexin-10 [Bos taurus]","gi|982921765|ref|XM_005205531.3|",2398,0,"PREDICTED: Bos taurus sorting nexin 10 (SNX10), transcript variant X3, mRNA","Q0IIL5",326,{"v":4e-104,"d":"4.00E-104"},"Sorting nexin-10","YOR357c",53.9,{"v":2e-07,"d":"2.00E-07"},"COG5391","pfam00787","PX","PX domain. PX domains bind to phosphoinositides.","GO:1990830|cellular response to leukemia inhibitory factor;GO:0060271|cilium morphogenesis;GO:0006897|endocytosis;GO:0007032|endosome organization;GO:0030316|osteoclast differentiation;GO:0071539|protein localization to centrosome;GO:0061512|protein localization to cilium;GO:0015031|protein transport;GO:0016050|vesicle organization;","GO:0005813|centrosome;GO:0005783|endoplasmic reticulum;GO:0005768|endosome;GO:0031313|extrinsic component of endosome membrane;GO:0019898|extrinsic component of membrane;GO:0005634|nucleus;","GO:0005545|1-phosphatidylinositol binding;GO:0051117|ATPase binding;GO:0035091|phosphatidylinositol binding;","K17924","SNX10_11; sorting nexin-10/11"]
["gene5316",44,26,51,35.6512853941779,259,146,200,222.580698120992,0.160172403515413,-2.64230249109222,{"v":5.60457689646096e-07,"d":"5.60E-07"},{"v":3.72737024319179e-05,"d":"3.73E-05"},"down","yes","FAM221A","protein_coding","chrNC_037331.1:71959113-72060102:-","gi|982921730|ref|XP_015325200.1|",6329,0,"PREDICTED: protein FAM221A isoform X4 [Bos taurus]","gi|982921729|ref|XM_015469714.1|",3964,0,"PREDICTED: Bos taurus family with sequence similarity 221, member A (FAM221A), transcript variant X4, mRNA","Q9BXU1",1619,0,"Serine/threonine-protein kinase 31","SPy1625_1",61.2,{"v":1e-08,"d":"1.00E-08"},"COG0515","pfam14753","DUF4475","Domain of unknown function (DUF4475). This family of proteins is found in eukaryotes. Proteins in this family are typically between 99 and 305 amino acids in length.","GO:0006401|RNA catabolic process;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0004518|nuclease activity;GO:0004674|protein serine/threonine kinase activity;","K16316","STK31, TDRD8; serine/threonine-protein kinase 31 [EC:2.7.11.1]"]
["gene5366",30,16,12,16.747639575689,70,70,91,84.701428991448,0.197725584740488,-2.33842853393622,0.000279143706006875,0.00661482481402172,"down","yes","MYO1G","protein_coding","chrNC_037331.1:76617171-76633186:+","gi|440909236|gb|ELR59167.1|",5140,0,"Myosin-Ig, partial [Bos mutus]","gi|982980781|ref|XM_005192314.3|",3262,0,"PREDICTED: Bos taurus myosin IG (MYO1G), mRNA","B0I1T2",1806,0,"Unconventional myosin-Ig","YKL129c",493,{"v":1e-152,"d":"1.00E-152"},"COG5022","pfam00063","Myosin_head","Myosin head (motor domain).","GO:0071976|cell gliding;GO:0031589|cell-substrate adhesion;GO:0006887|exocytosis;GO:0038096|Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0007018|microtubule-based movement;GO:0002456|T cell mediated immunity;GO:0072678|T cell migration;","GO:0070062|extracellular exosome;GO:0030175|filopodium;GO:0030027|lamellipodium;GO:0031256|leading edge membrane;GO:0016020|membrane;GO:0005902|microvillus;GO:0016459|myosin complex;GO:0001891|phagocytic cup;GO:0005886|plasma membrane;","GO:0003779|actin binding;GO:0005524|ATP binding;GO:0005516|calmodulin binding;GO:0008017|microtubule binding;GO:0003777|microtubule motor activity;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325|phosphatidylinositol-3,4-bisphosphate binding;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;","K10356","MYO1; myosin I"]
["gene5462",18415,17221,29452,19488.3494129814,40488,39840,42715,45172.8641142253,0.431417174782246,-1.2128444833404,0.0037396379630117,0.0484759703419749,"down","yes","LMOD2","protein_coding","chrNC_037331.1:87959332-87968300:+","gi|157427900|ref|NP_001098857.1|",2134,0,"leiomodin-2 [Bos taurus]","gi|157427899|ref|NM_001105387.1|",2091,0,"Bos taurus leiomodin 2 (LMOD2), mRNA","Q6P5Q4",726,0,"Leiomodin-2",".",".",".",".","pfam03250","Tropomodulin","Tropomodulin. Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments. Limited proteolysis shows this protein is composed of two domains. The amino terminal domain contains the tropomyosin binding function.","GO:0030041|actin filament polymerization;GO:0045010|actin nucleation;GO:0006936|muscle contraction;GO:0051694|pointed-end actin filament capping;GO:0030838|positive regulation of actin filament polymerization;GO:0045214|sarcomere organization;","GO:0005884|actin filament;GO:0031430|M band;GO:0030016|myofibril;GO:0030017|sarcomere;GO:0005865|striated muscle thin filament;","GO:0003779|actin binding;GO:0003785|actin monomer binding;GO:0005523|tropomyosin binding;",".","."]
["gene5495",0,40,29,22.0152345428986,201,186,225,224.605973861178,0.098017137142156,-3.35082218025548,{"v":8.17974936778532e-07,"d":"8.18E-07"},{"v":5.07018279699275e-05,"d":"5.07E-05"},"down","yes","LEP","protein_coding","chrNC_037331.1:92436837-92453660:+","gi|741924363|ref|XP_010802755.1|",828,{"v":3e-100,"d":"3.00E-100"},"PREDICTED: leptin isoform X1 [Bos taurus]","gi|982922011|ref|XM_010804453.2|",2952,0,"PREDICTED: Bos taurus leptin (LEP), transcript variant X1, mRNA","P50595",267,{"v":2e-81,"d":"2.00E-81"},"Leptin",".",".",".",".","pfam02024","Leptin","Leptin.","GO:1990051|activation of protein kinase C activity;GO:0008343|adult feeding behavior;GO:0044320|cellular response to leptin stimulus;GO:0006112|energy reserve metabolic process;GO:0032615|interleukin-12 production;GO:0032635|interleukin-6 production;GO:0072604|interleukin-6 secretion;GO:0072606|interleukin-8 secretion;GO:0050892|intestinal absorption;GO:0033210|leptin-mediated signaling pathway;GO:0032099|negative regulation of appetite;GO:0038108|negative regulation of appetite by leptin-mediated signaling pathway;GO:0010507|negative regulation of autophagy;GO:0046325|negative regulation of glucose import;GO:0006909|phagocytosis;GO:0045723|positive regulation of fatty acid biosynthetic process;GO:0046427|positive regulation of JAK-STAT cascade;GO:0043410|positive regulation of MAPK cascade;GO:1900745|positive regulation of p38MAPK cascade;GO:0014068|positive regulation of phosphatidylinositol 3-kinase signaling;GO:0051897|positive regulation of protein kinase B signaling;GO:0042102|positive regulation of T cell proliferation;GO:0032008|positive regulation of TOR signaling;GO:0032760|positive regulation of tumor necrosis factor production;GO:0032310|prostaglandin secretion;GO:0045765|regulation of angiogenesis;GO:0046850|regulation of bone remodeling;GO:0090335|regulation of brown fat cell differentiation;GO:0051726|regulation of cell cycle;GO:1900015|regulation of cytokine production involved in inflammatory response;GO:0001936|regulation of endothelial cell proliferation;GO:0032814|regulation of natural killer cell activation;GO:0042269|regulation of natural killer cell mediated cytotoxicity;GO:0032817|regulation of natural killer cell proliferation;GO:0050999|regulation of nitric-oxide synthase activity;GO:0032868|response to insulin;GO:0019953|sexual reproduction;GO:0030217|T cell differentiation;GO:0007260|tyrosine phosphorylation of STAT protein;","GO:0005615|extracellular space;GO:0005622|intracellular;","GO:0005179|hormone activity;GO:0051428|peptide hormone receptor binding;","K05424","LEP; leptin"]
["gene5743",0,0,0,0,135,48,105,105.976248774043,{"$error":"#NAME?"},{"$error":"#NAME?"},{"v":1.87853614272432e-13,"d":"1.88E-13"},{"v":5.10442997029216e-11,"d":"5.10E-11"},"down","yes","PRSS2","protein_coding","chrNC_037331.1:106071891-106075636:+","gi|157279044|gb|AAI34795.1|",1285,{"v":2e-177,"d":"2.00E-177"},"PRSS2 protein [Bos taurus]","gi|157279043|gb|BC134794.1|",777,0,"Bos taurus protease, serine, 2 (trypsin 2), mRNA (cDNA clone MGC:157375 IMAGE:8631384), complete cds","Q29463",491,{"v":1e-175,"d":"1.00E-175"},"Anionic trypsin","VC1200",109,{"v":1e-26,"d":"1.00E-26"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0030574|collagen catabolic process;GO:0007586|digestion;GO:0006508|proteolysis;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005509|calcium ion binding;GO:0004252|serine-type endopeptidase activity;",".","."]
["gene5907",18,9,12,11.3261369792084,45,71,53,62.0072445445921,0.182658285534092,-2.45278089783768,0.000747979950547723,0.0144878587705886,"down","yes","WDR86","protein_coding","chrNC_037331.1:113914551-113956869:-","gi|300797747|ref|NP_001178268.1|",1857,0,"WD repeat-containing protein 86 [Bos taurus]","gi|300797746|ref|NM_001191339.1|",1298,0,"Bos taurus WD repeat domain 86 (WDR86), mRNA",".",".",".",".",".",".",".",".","pfam00400","WD40","WD domain, G-beta repeat.",".",".",".",".","."]
["gene591",189,46,130,104.2586173746,644,147,455,458.896486966739,0.227194193757592,-2.13800212951732,0.00153220761704265,0.0253422698677355,"down","yes","IL1RAP","protein_coding","chrNC_037328.1:76566729-76723408:-","gi|982910677|ref|XP_015327398.1|",3089,0,"PREDICTED: interleukin-1 receptor accessory protein isoform X4 [Bos taurus]","gi|982910676|ref|XM_015471912.1|",4674,0,"PREDICTED: Bos taurus interleukin 1 receptor accessory protein (IL1RAP), transcript variant X5, mRNA","Q9NPH3",1057,0,"Interleukin-1 receptor accessory protein",".",".",".",".","pfam01582","TIR","TIR domain. The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.","GO:0019221|cytokine-mediated signaling pathway;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0045087|innate immune response;GO:0070498|interleukin-1-mediated signaling pathway;GO:0042094|interleukin-2 biosynthetic process;GO:0038172|interleukin-33-mediated signaling pathway;GO:0072602|interleukin-4 secretion;GO:1900006|positive regulation of dendrite development;GO:0032736|positive regulation of interleukin-13 production;GO:0032754|positive regulation of interleukin-5 production;GO:2000778|positive regulation of interleukin-6 secretion;GO:0051092|positive regulation of NF-kappaB transcription factor activity;GO:0051965|positive regulation of synapse assembly;GO:0065003|macromolecular complex assembly;","GO:0005576|extracellular region;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0004908|interleukin-1 receptor activity;GO:0002114|interleukin-33 receptor activity;GO:1990782|protein tyrosine kinase binding;","K04723","IL1RAP; interleukin 1 receptor accessory protein"]
["gene5917",1024,2030,1978,1539.63167458649,3433,2667,3239,3431.0928857996,0.448729231714659,-1.15608292585835,0.000166679488310639,0.00442207954171375,"down","yes","ACTR3B","protein_coding","chrNC_037331.1:115112567-115189514:+","gi|548464360|ref|XP_005679727.1|",1649,0,"PREDICTED: actin-related protein 3B [Capra hircus]","gi|982981283|ref|XM_015463199.1|",1233,0,"PREDICTED: Bos taurus ARP3 actin-related protein 3 homolog B (yeast) (ACTR3B), transcript variant X4, mRNA","Q9P1U1",604,0,"Actin-related protein 3B","YJR065c",384,{"v":2e-119,"d":"2.00E-119"},"COG5277","pfam00022","Actin","Actin.","GO:0034314|Arp2/3 complex-mediated actin nucleation;","GO:0005885|Arp2/3 protein complex;GO:0042995|cell projection;GO:0005737|cytoplasm;GO:0070062|extracellular exosome;","GO:0003779|actin binding;GO:0005524|ATP binding;","K18584","ACTR3, ARP3; actin-related protein 3"]
["gene600",1285,1019,1149,1021.72793146176,2604,1456,2162,2288.04939212598,0.446549770725187,-1.16310711332191,0.00224325103381687,0.0334739514884044,"down","yes","TP63","protein_coding","chrNC_037328.1:77387523-77688715:-","gi|823430605|ref|XP_004413020.2|",3505,0,"PREDICTED: tumor protein 63 isoform X1 [Odobenus rosmarus divergens]","gi|982910732|ref|XM_015471963.1|",5044,0,"PREDICTED: Bos taurus tumor protein p63 (TP63), transcript variant X1, mRNA","O88898",1322,0,"Tumor protein 63",".",".",".",".","pfam00870","P53","P53 DNA-binding domain. This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.","GO:0048646|anatomical structure formation involved in morphogenesis;GO:0009887|organ morphogenesis;GO:0006915|apoptotic process;GO:0007569|cell aging;GO:0030154|cell differentiation;GO:0008283|cell proliferation;GO:0006974|cellular response to DNA damage stimulus;GO:0034644|cellular response to UV;GO:0006338|chromatin remodeling;GO:0060197|cloacal septation;GO:0006978|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator;GO:0007499|ectoderm and mesoderm interaction;GO:0035115|embryonic forelimb morphogenesis;GO:0035116|embryonic hindlimb morphogenesis;GO:0030326|embryonic limb morphogenesis;GO:0009913|epidermal cell differentiation;GO:0010481|epidermal cell division;GO:0008544|epidermis development;GO:0002064|epithelial cell development;GO:0030855|epithelial cell differentiation;GO:0001736|establishment of planar polarity;GO:0061436|establishment of skin barrier;GO:0048807|female genitalia morphogenesis;GO:0001942|hair follicle development;GO:0031069|hair follicle morphogenesis;GO:0042771|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0030216|keratinocyte differentiation;GO:0043616|keratinocyte proliferation;GO:0031571|mitotic G1 DNA damage checkpoint;GO:0001738|morphogenesis of a polarized epithelium;GO:0010259|multicellular organismal aging;GO:0007275|multicellular organismal development;GO:0043066|negative regulation of apoptotic process;GO:2000773|negative regulation of cellular senescence;GO:0033147|negative regulation of intracellular estrogen receptor signaling pathway;GO:0045617|negative regulation of keratinocyte differentiation;GO:2000381|negative regulation of mesoderm development;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045892|negative regulation of transcription, DNA-templated;GO:0051402|neuron apoptotic process;GO:0007219|Notch signaling pathway;GO:0042475|odontogenesis of dentin-containing tooth;GO:0007389|pattern specification process;GO:0030859|polarized epithelial cell differentiation;GO:2001235|positive regulation of apoptotic signaling pathway;GO:1902808|positive regulation of cell cycle G1/S phase transition;GO:2000271|positive regulation of fibroblast apoptotic process;GO:0010838|positive regulation of keratinocyte proliferation;GO:0002053|positive regulation of mesenchymal cell proliferation;GO:0045747|positive regulation of Notch signaling pathway;GO:0045669|positive regulation of osteoblast differentiation;GO:1904674|positive regulation of somatic stem cell population maintenance;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0036342|post-anal tail morphogenesis;GO:0030850|prostate gland development;GO:0060513|prostatic bud formation;GO:0051289|protein homotetramerization;GO:0009954|proximal/distal pattern formation;GO:0043281|regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0010482|regulation of epidermal cell division;GO:0043523|regulation of neuron apoptotic process;GO:0001302|replicative cell aging;GO:0010332|response to gamma radiation;GO:0010165|response to X-ray;GO:0001501|skeletal system development;GO:0098773|skin epidermis development;GO:0043589|skin morphogenesis;GO:0048745|smooth muscle tissue development;GO:0007283|spermatogenesis;GO:0060529|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development;GO:0048485|sympathetic nervous system development;GO:0060157|urinary bladder development;","GO:0000785|chromatin;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0030425|dendrite;GO:0005794|Golgi apparatus;GO:0043005|neuron projection;GO:0000790|nuclear chromatin;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0032991|macromolecular complex;GO:0005791|rough endoplasmic reticulum;GO:0005667|transcription factor complex;","GO:0003682|chromatin binding;GO:0003684|damaged DNA binding;GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0003690|double-stranded DNA binding;GO:0042802|identical protein binding;GO:0097371|MDM2/MDM4 family protein binding;GO:0046872|metal ion binding;GO:0002039|p53 binding;GO:0019904|protein domain specific binding;GO:0043565|sequence-specific DNA binding;GO:0000989|transcription factor activity, transcription factor binding;GO:0044212|transcription regulatory region DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;GO:0050699|WW domain binding;","K10149","TP63; tumor protein p63"]
["gene6016",25,4,9,10.5905463402046,266,27,172,171.418313165852,0.0617818840041784,-4.01667232395578,{"v":7.90502424634035e-05,"d":"7.91E-05"},0.00239679327069433,"down","yes","SYT1","protein_coding","chrNC_037332.1:8441271-9050206:+","gi|674036514|ref|XP_008850303.1|",1686,0,"PREDICTED: synaptotagmin-1 isoform X2 [Nannospalax galili]","gi|942098529|ref|XM_005910224.2|",4534,0,"PREDICTED: Bos mutus synaptotagmin I (SYT1), transcript variant X1, mRNA","Q5R4J5",652,0,"Synaptotagmin-1","SPAPYUK71.03c",59.7,{"v":7e-08,"d":"7.00E-08"},"COG5038","pfam00168","C2","C2 domain.","GO:0030154|cell differentiation;GO:0007269|neurotransmitter secretion;","GO:0030054|cell junction;GO:0042584|chromaffin granule membrane;GO:0016021|integral component of membrane;GO:0030672|synaptic vesicle membrane;","GO:0005544|calcium-dependent phospholipid binding;GO:0046872|metal ion binding;","K15290","SYT1; synaptotagmin-1"]
["gene6023",10,6,4,5.80102497803407,48,57,45,55.1029397416686,0.105276143255336,-3.24774955222435,{"v":9.90694758962984e-05,"d":"9.91E-05"},0.00287825923680125,"down","yes","LOC112446841","snRNA","chrNC_037332.1:10229151-10229255:-","gi|965792038|ref|XP_014963564.1|",118,{"v":4e-06,"d":"4.00E-06"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC106992171 [Ovis aries musimon]","gi|49457576|emb|AL844155.6|",55,{"v":6e-19,"d":"6.00E-19"},"Mouse DNA sequence from clone RP23-163L4 on chromosome 2, complete sequence",".",".",".",".",".",".",".",".","pfam06699","PIG-F","GPI biosynthesis protein family Pig-F. PIG-F is involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis.",".",".",".",".","."]
["gene6107",5495,4190,5890,4614.20818424232,27534,8859,19460,20567.0058781282,0.224350020201494,-2.15617678096628,{"v":2.13542538525381e-05,"d":"2.14E-05"},0.00080377073438887,"down","yes","NUDT4","protein_coding","chrNC_037332.1:23191665-23208110:+","gi|795662471|ref|XP_011743007.1|",938,{"v":6e-115,"d":"6.00E-115"},"PREDICTED: LOW QUALITY PROTEIN: diphosphoinositol polyphosphate phosphohydrolase 2 [Macaca nemestrina]","gi|982924624|ref|XM_005206121.3|",3496,0,"PREDICTED: Bos taurus nudix hydrolase 4 (NUDT4), transcript variant X1, mRNA","Q5RAF0",334,{"v":4e-105,"d":"4.00E-105"},"Diphosphoinositol polyphosphate phosphohydrolase 2",".",".",".",".","pfam00293","NUDIX","NUDIX domain.",".","GO:0005737|cytoplasm;","GO:0008486|diphosphoinositol-polyphosphate diphosphatase activity;GO:0052840|inositol diphosphate tetrakisphosphate diphosphatase activity;GO:0052846|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity;GO:0052847|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;GO:0052843|inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity;GO:0052848|inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity;GO:0052844|inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity;GO:0052845|inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity;GO:0046872|metal ion binding;GO:0030515|snoRNA binding;","K07766","E3.6.1.52; diphosphoinositol-polyphosphate diphosphatase [EC:3.6.1.52]"]
["gene6157",8,16,27,15.6207528694139,62,110,104,101.083434579439,0.154533261898001,-2.69401069617153,{"v":1.47783886663846e-05,"d":"1.48E-05"},0.000593986862491215,"down","yes","HOXC4","protein_coding","chrNC_037332.1:25977635-25994974:-","gi|154800435|ref|NP_038581.2|",1048,{"v":1e-125,"d":"1.00E-125"},"homeobox protein Hox-C4 [Mus musculus]","gi|965872572|ref|XM_015109104.1|",7996,0,"PREDICTED: Ovis aries musimon homeobox protein Hox-C4 (LOC105611007), transcript variant X3, mRNA","Q08624",408,{"v":4e-127,"d":"4.00E-127"},"Homeobox protein Hox-C4",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009952|anterior/posterior pattern specification;GO:0051216|cartilage development;GO:0048562|embryonic organ morphogenesis;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0001501|skeletal system development;","GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0071837|HMG box domain binding;GO:0000980|RNA polymerase II distal enhancer sequence-specific DNA binding;GO:0001205|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding;","K09304","HOX_4; homeobox protein HoxA/B/C/D4"]
["gene6158",10,8,34,15.6701093446903,76,170,168,151.437706842401,0.103475611665184,-3.27263731823295,0.000131427504099757,0.00365117635780931,"down","yes","HOXC5","protein_coding","chrNC_037332.1:25998379-25999826:-","gi|300797993|ref|NP_001178280.1|",1012,{"v":2e-136,"d":"2.00E-136"},"homeobox protein Hox-C5 [Bos taurus]","gi|300797992|ref|NM_001191351.1|",751,0,"Bos taurus homeobox C5 (HOXC5), mRNA","P32043",391,{"v":6e-137,"d":"6.00E-137"},"Homeobox protein Hox-C5",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009952|anterior/posterior pattern specification;GO:0048706|embryonic skeletal system development;GO:0006351|transcription, DNA-templated;","GO:0030054|cell junction;GO:0005654|nucleoplasm;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;","K09305","HOX_5; homeobox protein HoxA/B/C5"]
["gene6160",118,301,130,169.32237575691,518,1119,825,902.073593388882,0.187703505565222,-2.41347250058253,0.000241969033163544,0.005855486416615,"down","yes","HOXC6","protein_coding","chrNC_037332.1:26002110-26013517:-","gi|568991417|ref|XP_006520531.1|",1145,{"v":2e-139,"d":"2.00E-139"},"PREDICTED: homeobox protein Hox-C6 isoform X1 [Mus musculus]","gi|982981570|ref|XM_010827624.2|",7500,0,"PREDICTED: Bos taurus homeobox C6 (HOXC6), transcript variant X1, mRNA","P10629",417,{"v":5e-131,"d":"5.00E-131"},"Homeobox protein Hox-C6",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009952|anterior/posterior pattern specification;GO:0048706|embryonic skeletal system development;GO:0006351|transcription, DNA-templated;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;","K09306","HOX_6; homeobox protein HoxA/B/C6"]
["gene6161",60,58,81,59.5218719264112,524,454,493,540.426469585535,0.110138705774459,-3.18260653410724,{"v":4.54191546726769e-14,"d":"4.54E-14"},{"v":1.36405673891173e-11,"d":"1.36E-11"},"down","yes","HOXC8","protein_coding","chrNC_037332.1:26019840-26023432:-","gi|471366946|ref|XP_004374005.1|",1188,{"v":1e-155,"d":"1.00E-155"},"PREDICTED: homeobox protein Hox-C8 [Trichechus manatus latirostris]","gi|942073622|ref|XM_005902098.2|",2146,0,"PREDICTED: Bos mutus homeobox C8 (HOXC8), mRNA","P09025",462,{"v":5e-157,"d":"5.00E-157"},"Homeobox protein Hox-C8",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009952|anterior/posterior pattern specification;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030182|neuron differentiation;GO:0048705|skeletal system morphogenesis;GO:0006351|transcription, DNA-templated;","GO:0015630|microtubule cytoskeleton;GO:0005654|nucleoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;","K09308","HOX_8; homeobox protein HoxB/C/D8"]
["gene622",89,872,1091,644.03498661301,8280,3982,6819,7017.61841280946,0.0917740106012938,-3.44577053379559,{"v":1.36275876651835e-05,"d":"1.36E-05"},0.000556235627575607,"down","yes","ADIPOQ","protein_coding","chrNC_037328.1:80414393-80427659:-","gi|803004088|ref|XP_011952832.1|",1149,{"v":4e-147,"d":"4.00E-147"},"PREDICTED: adiponectin isoform X3 [Ovis aries]","gi|982976324|ref|XM_015462053.1|",2477,0,"PREDICTED: Bos taurus adiponectin, C1Q and collagen domain containing (ADIPOQ), transcript variant X2, mRNA","Q3Y5Z3",442,{"v":3e-147,"d":"3.00E-147"},"Adiponectin",".",".",".",".","pfam00386","C1q","C1q domain. C1q is a subunit of the C1 enzyme complex that activates the serum complement system.","GO:0050873|brown fat cell differentiation;GO:0035690|cellular response to drug;GO:0032869|cellular response to insulin stimulus;GO:0070994|detection of oxidative stress;GO:0006635|fatty acid beta-oxidation;GO:0019395|fatty acid oxidation;GO:0042593|glucose homeostasis;GO:0006006|glucose metabolic process;GO:0034383|low-density lipoprotein particle clearance;GO:0045776|negative regulation of blood pressure;GO:0030336|negative regulation of cell migration;GO:2000279|negative regulation of DNA biosynthetic process;GO:0070373|negative regulation of ERK1 and ERK2 cascade;GO:0045599|negative regulation of fat cell differentiation;GO:0045721|negative regulation of gluconeogenesis;GO:0030853|negative regulation of granulocyte differentiation;GO:0034115|negative regulation of heterotypic cell-cell adhesion;GO:0043124|negative regulation of I-kappaB kinase/NF-kappaB signaling;GO:0050728|negative regulation of inflammatory response;GO:0090317|negative regulation of intracellular protein transport;GO:0045715|negative regulation of low-density lipoprotein particle receptor biosynthetic process;GO:0010745|negative regulation of macrophage derived foam cell differentiation;GO:0045650|negative regulation of macrophage differentiation;GO:0043407|negative regulation of MAP kinase activity;GO:2000590|negative regulation of metanephric mesenchymal cell migration;GO:0050765|negative regulation of phagocytosis;GO:0010642|negative regulation of platelet-derived growth factor receptor signaling pathway;GO:2000584|negative regulation of platelet-derived growth factor receptor-alpha signaling pathway;GO:0031953|negative regulation of protein autophosphorylation;GO:1900121|negative regulation of receptor binding;GO:0050805|negative regulation of synaptic transmission;GO:0045892|negative regulation of transcription, DNA-templated;GO:0032720|negative regulation of tumor necrosis factor production;GO:0010804|negative regulation of tumor necrosis factor-mediated signaling pathway;GO:1904706|negative regulation of vascular smooth muscle cell proliferation;GO:2000481|positive regulation of cAMP-dependent protein kinase activity;GO:0032270|positive regulation of cellular protein metabolic process;GO:0010875|positive regulation of cholesterol efflux;GO:0045923|positive regulation of fatty acid metabolic process;GO:0046326|positive regulation of glucose import;GO:2000467|positive regulation of glycogen (starch) synthase activity;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;GO:0032757|positive regulation of interleukin-8 production;GO:2000478|positive regulation of metanephric glomerular visceral epithelial cell development;GO:0071639|positive regulation of monocyte chemotactic protein-1 production;GO:0033034|positive regulation of myeloid cell apoptotic process;GO:0010739|positive regulation of protein kinase A signaling;GO:0001934|positive regulation of protein phosphorylation;GO:2000534|positive regulation of renal albumin absorption;GO:0009967|positive regulation of signal transduction;GO:0070208|protein heterotrimerization;GO:0051260|protein homooligomerization;GO:0072659|protein localization to plasma membrane;GO:0010906|regulation of glucose metabolic process;GO:0009749|response to glucose;GO:0034612|response to tumor necrosis factor;","GO:0005623|cell;GO:0071944|cell periphery;GO:0009986|cell surface;GO:0005581|collagen trimer;GO:0005783|endoplasmic reticulum;GO:0005615|extracellular space;GO:0048471|perinuclear region of cytoplasm;","GO:0005179|hormone activity;GO:0042802|identical protein binding;GO:0042803|protein homodimerization activity;GO:0033691|sialic acid binding;GO:0005102|receptor binding;","K07296","ACDC; adiponectin"]
["gene6244",23,19,65,32.1838765366847,1250,128,888,834.728446508233,0.0385561036901445,-4.69689692324115,{"v":5.69268406740198e-06,"d":"5.69E-06"},0.000264094258743164,"down","yes","KRT80","protein_coding","chrNC_037332.1:27732698-27757608:+","gi|528948654|ref|XP_005206272.1|",2341,0,"PREDICTED: keratin, type II cytoskeletal 80 isoform X1 [Bos taurus]","gi|982924821|ref|XM_005206215.3|",4394,0,"PREDICTED: Bos taurus keratin 80, type II (KRT80), transcript variant X1, mRNA","A0JND2",838,0,"Keratin, type II cytoskeletal 80",".",".",".",".","pfam00038","Filament","Intermediate filament protein.",".","GO:0045095|keratin filament;","GO:0005198|structural molecule activity;","K07605","KRT2; type II keratin, basic"]
["gene6308",5,4,0,2.61398690100742,1,96,32,47.1557071436753,0.0554330972716208,-4.17310857068364,0.000284834397800976,0.00672176195505347,"down","yes","AQP2","protein_coding","chrNC_037332.1:29923335-29931727:-","gi|982925041|ref|XP_015326476.1|",1142,{"v":1e-141,"d":"1.00E-141"},"PREDICTED: aquaporin-2 isoform X1 [Bos taurus]","gi|982925040|ref|XM_015470990.1|",2780,0,"PREDICTED: Bos taurus aquaporin 2 (AQP2), transcript variant X1, mRNA","P79099",357,{"v":3e-121,"d":"3.00E-121"},"Aquaporin-2","SP1778",84.3,{"v":9e-17,"d":"9.00E-17"},"COG0580","pfam00230","MIP","Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.","GO:0071280|cellular response to copper ion;GO:0071288|cellular response to mercury ion;GO:0042631|cellular response to water deprivation;GO:0034220|ion transmembrane transport;GO:0072205|metanephric collecting duct development;GO:0003097|renal water transport;","GO:0016324|apical plasma membrane;GO:0016323|basolateral plasma membrane;GO:0030659|cytoplasmic vesicle membrane;GO:0070062|extracellular exosome;GO:0005794|Golgi apparatus;GO:0005887|integral component of plasma membrane;GO:0055037|recycling endosome;","GO:0015168|glycerol transmembrane transporter activity;GO:0015250|water channel activity;","K09865","AQP2; aquaporin-2"]
["gene6422",63,40,126,68.2252969235658,966,462,722,791.230657454962,0.0862268117150772,-3.53571965324547,{"v":5.05348976895801e-07,"d":"5.05E-07"},{"v":3.40049803297502e-05,"d":"3.40E-05"},"down","yes","AMIGO2","protein_coding","chrNC_037332.1:33169556-33172868:+","gi|329664987|ref|NP_001192715.1|",2539,0,"amphoterin-induced protein 2 precursor [Bos taurus]","gi|329664986|ref|NM_001205786.1|",2948,0,"Bos taurus adhesion molecule with Ig-like domain 2 (AMIGO2), mRNA","Q86SJ2",863,0,"Amphoterin-induced protein 2","SPy1798",54.3,{"v":2e-06,"d":"2.00E-06"},"COG4886","pfam13855","LRR_8","Leucine rich repeat.","GO:0007157|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007156|homophilic cell adhesion via plasma membrane adhesion molecules;GO:0043066|negative regulation of apoptotic process;GO:0043069|negative regulation of programmed cell death;","GO:0016021|integral component of membrane;GO:0005634|nucleus;GO:0005886|plasma membrane;",".",".","."]
["gene6444",1247,1052,1868,1243.45938644002,3544,2011,2873,3099.72122137916,0.401152006142916,-1.31777908275933,0.00050717694890375,0.0106528162800675,"down","yes","ADAMTS20","protein_coding","chrNC_037332.1:36904946-37121155:+","gi|982925347|ref|XP_015326515.1|",9800,0,"PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X1 [Bos taurus]","gi|982925346|ref|XM_015471029.1|",6047,0,"PREDICTED: Bos taurus ADAM metallopeptidase with thrombospondin type 1 motif 20 (ADAMTS20), transcript variant X1, mRNA","P59511",3021,0,"A disintegrin and metalloproteinase with thrombospondin motifs 20",".",".",".",".","pfam08685","GON","GON domain. The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.","GO:0030198|extracellular matrix organization;GO:0043066|negative regulation of apoptotic process;GO:0045636|positive regulation of melanocyte differentiation;GO:0009967|positive regulation of signal transduction;GO:0006508|proteolysis;GO:0048070|regulation of developmental pigmentation;","GO:0005615|extracellular space;","GO:0004175|endopeptidase activity;GO:0004222|metalloendopeptidase activity;GO:0008270|zinc ion binding;","K09609","ADAMTS20; a disintegrin and metalloproteinase with thrombospondin motifs 20 [EC:3.4.24.-]"]
["gene6555",1723,1640,2059,1618.87427456668,3652,2454,3032,3360.05835744552,0.481799451780184,-1.05349534289349,0.000923476902179897,0.0169656918841562,"down","yes","TMBIM4","protein_coding","chrNC_037332.1:47645293-47661704:+","gi|62460524|ref|NP_001014914.1|",900,{"v":4e-112,"d":"4.00E-112"},"protein lifeguard 4 [Bos taurus]","gi|76253790|ref|NM_001014914.2|",2344,0,"Bos taurus transmembrane BAX inhibitor motif containing 4 (TMBIM4), mRNA","Q9DA39",305,{"v":4e-96,"d":"4.00E-96"},"Protein lifeguard 4","SPCC576.04",115,{"v":2e-27,"d":"2.00E-27"},"COG0670","pfam01027","Bax1-I","Inhibitor of apoptosis-promoting Bax1. Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner.","GO:0006915|apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0050848|regulation of calcium-mediated signaling;","GO:0005794|Golgi apparatus;GO:0000139|Golgi membrane;GO:0005795|Golgi stack;GO:0016021|integral component of membrane;",".","K06890","K06890; uncharacterized protein"]
["gene6609",122,140,145,122.209146856115,263,233,240,270.442604521943,0.451885704444172,-1.14597017729805,0.00271167300923717,0.0383954057699978,"down","yes","METTL1","protein_coding","chrNC_037332.1:55693253-55697229:+","gi|528949479|ref|XP_005206619.1|",1693,0,"PREDICTED: tRNA (guanine-N(7)-)-methyltransferase isoform X1 [Bos taurus]","gi|982925672|ref|XM_005206562.3|",1576,0,"PREDICTED: Bos taurus methyltransferase like 1 (METTL1), transcript variant X1, mRNA","Q2YDF1",521,0,"tRNA (guanine-N(7)-)-methyltransferase","YDL201w",273,{"v":3e-85,"d":"3.00E-85"},"COG0220","pfam02390","Methyltransf_4","Putative methyltransferase. This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.","GO:0036265|RNA (guanine-N7)-methylation;GO:0006400|tRNA modification;","GO:0005829|cytosol;GO:0005730|nucleolus;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0043527|tRNA methyltransferase complex;","GO:0008176|tRNA (guanine-N7-)-methyltransferase activity;GO:0000049|tRNA binding;","K03439","trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"]
["gene6658",0,0,0,0,0,52,31,30.2735131295016,{"$error":"#NAME?"},{"$error":"#NAME?"},{"v":9.29444018082601e-06,"d":"9.29E-06"},0.000404237306096261,"down","yes","RDH16","protein_coding","chrNC_037332.1:56530305-56538401:+","gi|115495313|ref|NP_001069264.1|",1611,0,"retinol dehydrogenase 16 [Bos taurus]","gi|982925773|ref|XM_005206607.3|",2934,0,"PREDICTED: Bos taurus retinol dehydrogenase 16 (all-trans) (RDH16), transcript variant X11, mRNA","O75452",503,{"v":3e-168,"d":"3.00E-168"},"Retinol dehydrogenase 16",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0006629|lipid metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0031090|organelle membrane;","GO:0009055|electron carrier activity;GO:0004745|retinol dehydrogenase activity;","K11154","RDH16; retinol dehydrogenase 16 [EC:1.1.1.-]"]
["gene6700",5766,850,57204,19349.8995398411,99894,83957,91762,101271.959120822,0.191068679897421,-2.3878367847032,0.00194029197820909,0.0301479583207121,"down","yes","MYL6B","protein_coding","chrNC_037332.1:57165320-57169503:-","gi|115496556|ref|NP_001069181.1|",933,{"v":1e-123,"d":"1.00E-123"},"myosin light chain 6B [Bos taurus]","gi|982925703|ref|XM_005206579.3|",865,0,"PREDICTED: Bos taurus myosin light chain 6B (MYL6B), transcript variant X1, mRNA","P14649",305,{"v":4e-102,"d":"4.00E-102"},"Myosin light chain 6B","SPAC3A12.14",107,{"v":5e-27,"d":"5.00E-27"},"COG5126","pfam13499","EF-hand_7","EF-hand domain pair.","GO:0006936|muscle contraction;GO:0030049|muscle filament sliding;GO:0007519|skeletal muscle tissue development;","GO:0005829|cytosol;GO:0070062|extracellular exosome;GO:0005859|muscle myosin complex;GO:0016459|myosin complex;GO:0016461|unconventional myosin complex;","GO:0005509|calcium ion binding;GO:0003774|motor activity;GO:0008307|structural constituent of muscle;","K12751","MYL6; myosin light chain 6"]
["gene6709",280,380,267,279.508700586007,1011,588,823,890.748916939729,0.313790671277256,-1.67212563200803,{"v":2.18595664890427e-05,"d":"2.19E-05"},0.000819547032193005,"down","yes","SUOX","protein_coding","chrNC_037332.1:57314956-57319225:-","gi|77735689|ref|NP_001029538.1|",2836,0,"sulfite oxidase, mitochondrial [Bos taurus]","gi|77735688|ref|NM_001034366.1|",2177,0,"Bos taurus sulfite oxidase (SUOX), mRNA","P51687",948,0,"Sulfite oxidase, mitochondrial","MT1801",237,{"v":2e-69,"d":"2.00E-69"},"COG2041","pfam03404","Mo-co_dimer","Mo-co oxidoreductase dimerization domain. This domain is found in molybdopterin cofactor (Mo-co) oxidoreductases. It is involved in dimer formation, and has an Ig-fold structure.","GO:0042128|nitrate assimilation;GO:0070221|sulfide oxidation, using sulfide:quinone oxidoreductase;","GO:0005758|mitochondrial intermembrane space;GO:0005759|mitochondrial matrix;","GO:0020037|heme binding;GO:0030151|molybdenum ion binding;GO:0043546|molybdopterin cofactor binding;GO:0008482|sulfite oxidase activity;","K00387","SUOX; sulfite oxidase [EC:1.8.3.1]"]
["gene6721",161,103,348,182.593590584528,1594,877,1339,1400.97713139734,0.130333027208237,-2.93972537666164,{"v":3.020316693079e-06,"d":"3.02E-06"},0.000153605446649264,"down","yes","GDF11","protein_coding","chrNC_037332.1:57505355-57512998:-","gi|803315730|ref|XP_012016146.1|",1859,0,"PREDICTED: growth/differentiation factor 11 isoform X2 [Ovis aries musimon]","gi|965898260|ref|XM_012160756.2|",1845,0,"PREDICTED: Ovis aries musimon growth differentiation factor 11 (GDF11), transcript variant X2, mRNA","O95390",712,0,"Growth/differentiation factor 11",".",".",".",".","pfam00688","TGFb_propeptide","TGF-beta propeptide. This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein.","GO:0048593|camera-type eye morphogenesis;GO:0048468|cell development;GO:0048469|cell maturation;GO:0007498|mesoderm development;GO:0001656|metanephros development;GO:0008285|negative regulation of cell proliferation;GO:0045665|negative regulation of neuron differentiation;GO:0007399|nervous system development;GO:0031016|pancreas development;GO:0010862|positive regulation of pathway-restricted SMAD protein phosphorylation;GO:0042981|regulation of apoptotic process;GO:0043408|regulation of MAPK cascade;GO:0060021|palate development;GO:0001501|skeletal system development;GO:0060395|SMAD protein signal transduction;GO:0021512|spinal cord anterior/posterior patterning;GO:0001657|ureteric bud development;","GO:0005615|extracellular space;GO:0043231|intracellular membrane-bounded organelle;GO:0005654|nucleoplasm;GO:0032991|macromolecular complex;","GO:0005125|cytokine activity;GO:0008083|growth factor activity;GO:0005160|transforming growth factor beta receptor binding;","K05497","GDF8_11; growth differentiation factor 8/11"]
["gene6918",1540,1077,1354,1170.15441713863,3556,1587,2803,2923.33560701813,0.400280561126614,-1.32091653923481,0.00174335380842226,0.0279209780598211,"down","yes","GNPTAB","protein_coding","chrNC_037332.1:65572215-65656028:-","gi|296487596|tpg|DAA29709.1|",6491,0,"TPA: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits [Bos taurus]","gi|741926558|ref|XM_010805142.1|",4953,0,"PREDICTED: Bos taurus N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (GNPTAB), transcript variant X2, mRNA","Q3T906",2227,0,"N-acetylglucosamine-1-phosphotransferase subunits alpha/beta",".",".",".",".","pfam06464","DMAP_binding","DMAP1-binding Domain. This domain binds DMAP1, a transcriptional co-repressor.","GO:0046835|carbohydrate phosphorylation;GO:0007040|lysosome organization;GO:0016256|N-glycan processing to lysosome;GO:0033299|secretion of lysosomal enzymes;","GO:0005794|Golgi apparatus;GO:0000139|Golgi membrane;GO:0016021|integral component of membrane;","GO:0005509|calcium ion binding;GO:0003976|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity;","K08239","GNPTAB; UDP-N-acetylglucosamine-lysosomal-enzyme [EC:2.7.8.17]"]
["gene6964",128,64,50,69.689787464662,142,215,139,182.152627633985,0.38259007498204,-1.38612864660823,0.00210328495277465,0.031919586695539,"down","yes","ALDH1L2","protein_coding","chrNC_037332.1:68542281-68603070:-","gi|329299045|ref|NP_001178320.1|",4884,0,"mitochondrial 10-formyltetrahydrofolate dehydrogenase [Bos taurus]","gi|329299044|ref|NM_001191391.1|",5708,0,"Bos taurus aldehyde dehydrogenase 1 family member L2 (ALDH1L2), mRNA","Q3SY69",1793,0,"Mitochondrial 10-formyltetrahydrofolate dehydrogenase","BS_dhaS",427,{"v":2e-132,"d":"2.00E-132"},"COG1012","pfam00171","Aldedh","Aldehyde dehydrogenase family. This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases EC:1.2.1.3. Succinate-semialdehyde dehydrogenase EC:1.2.1.16. Lactaldehyde dehydrogenase EC:1.2.1.22. Benzaldehyde dehydrogenase EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase EC: 1.5.1.12. Acetaldehyde dehydrogenase EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase EC:1.2.1.41. This family also includes omega crystallin, an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity.","GO:0009258|10-formyltetrahydrofolate catabolic process;GO:0009058|biosynthetic process;GO:0046655|folic acid metabolic process;GO:0006730|one-carbon metabolic process;","GO:0070062|extracellular exosome;GO:0005759|mitochondrial matrix;GO:0005739|mitochondrion;GO:0005634|nucleus;","GO:0004029|aldehyde dehydrogenase (NAD) activity;GO:0016155|formyltetrahydrofolate dehydrogenase activity;GO:0016742|hydroxymethyl-, formyl- and related transferase activity;","K00289","E1.5.1.6, FTHFD; formyltetrahydrofolate dehydrogenase [EC:1.5.1.6]"]
["gene7010",4,32,77,35.1778244697796,360,290,367,373.459957535837,0.0941943674547865,-3.40821539626362,{"v":5.87365734841219e-08,"d":"5.87E-08"},{"v":5.2206018008582e-06,"d":"5.22E-06"},"down","yes","LOC616957","protein_coding","chrNC_037332.1:73866563-73874143:+","gi|742201313|ref|XP_010857940.1|",1779,0,"PREDICTED: apolipoprotein L6 [Bison bison bison]","gi|982982029|ref|XM_869107.4|",1879,0,"PREDICTED: Bos taurus apolipoprotein L6 (LOC616957), mRNA","Q9BWW8",281,{"v":2e-83,"d":"2.00E-83"},"Apolipoprotein L6",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006869|lipid transport;GO:0042157|lipoprotein metabolic process;","GO:0005737|cytoplasm;GO:0005576|extracellular region;","GO:0008289|lipid binding;","K14480","APOL; apolipoprotein L"]
["gene7030",52,28,65,42.6914095177942,261,157,187,222.672450010354,0.19172290741764,-2.38290537163504,{"v":2.35915932069795e-06,"d":"2.36E-06"},0.000124877874914347,"down","yes","APOL3","protein_coding","chrNC_037332.1:74669795-74711376:+","gi|154152105|ref|NP_001093821.1|",1218,{"v":2e-156,"d":"2.00E-156"},"apolipoprotein L3 [Bos taurus]","gi|982926379|ref|XM_005206824.3|",1404,0,"PREDICTED: Bos taurus apolipoprotein L, 3 (APOL3), transcript variant X6, mRNA","O95236",167,{"v":2e-43,"d":"2.00E-43"},"Apolipoprotein L3",".",".",".",".","pfam05461","ApoL","Apolipoprotein L. Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.","GO:0006954|inflammatory response;GO:0042157|lipoprotein metabolic process;GO:0043123|positive regulation of I-kappaB kinase/NF-kappaB signaling;","GO:0005737|cytoplasm;GO:0005576|extracellular region;GO:0016020|membrane;","GO:0008289|lipid binding;GO:0005319|lipid transporter activity;","K14480","APOL; apolipoprotein L"]
["gene7069",34,30,44,32.2060723073854,392,141,329,317.022418881103,0.101589258012267,-3.29918023442832,{"v":3.19516460003056e-08,"d":"3.20E-08"},{"v":3.09021156621939e-06,"d":"3.09E-06"},"down","yes","PKP2","protein_coding","chrNC_037332.1:77001539-77081739:+","gi|139948912|ref|NP_001077198.1|",4401,0,"plakophilin-2 [Bos taurus]","gi|139948911|ref|NM_001083729.1|",3013,0,"Bos taurus plakophilin 2 (PKP2), mRNA","Q99959",1432,0,"Plakophilin-2",".",".",".",".","pfam00514","Arm","Armadillo/beta-catenin-like repeat. Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.","GO:0086073|bundle of His cell-Purkinje myocyte adhesion involved in cell communication;GO:0086002|cardiac muscle cell action potential involved in contraction;GO:0086064|cell communication by electrical coupling involved in cardiac conduction;GO:0098609|cell-cell adhesion;GO:0086019|cell-cell signaling involved in cardiac conduction;GO:0070268|cornification;GO:0002159|desmosome assembly;GO:0007507|heart development;GO:0045110|intermediate filament bundle assembly;GO:0031424|keratinization;GO:0048496|maintenance of organ identity;GO:0010765|positive regulation of sodium ion transport;GO:0072659|protein localization to plasma membrane;GO:0086091|regulation of heart rate by cardiac conduction;GO:0098911|regulation of ventricular cardiac muscle cell action potential;GO:0086005|ventricular cardiac muscle cell action potential;GO:0055010|ventricular cardiac muscle tissue morphogenesis;","GO:0005912|adherens junction;GO:0030054|cell junction;GO:0005911|cell-cell junction;GO:0001533|cornified envelope;GO:0030057|desmosome;GO:0016021|integral component of membrane;GO:0014704|intercalated disc;GO:0005882|intermediate filament;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0045294|alpha-catenin binding;GO:0045296|cadherin binding;GO:0086083|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication;GO:0019215|intermediate filament binding;GO:0044325|ion channel binding;GO:0005080|protein kinase C binding;GO:0032947|protein complex scaffold;GO:0017080|sodium channel regulator activity;","K12642","PKP2; plakophilin 2"]
["gene7128",1153,820,1025,884.026763469861,3174,1009,2265,2374.23396770376,0.372341890266546,-1.42530015938535,0.0014623547061863,0.0243621431678965,"down","yes","RASSF8","protein_coding","chrNC_037332.1:83867388-84005186:-","gi|440900368|gb|ELR51519.1|",1901,0,"Ras association domain-containing protein 8, partial [Bos mutus]","gi|982926636|ref|XM_005206936.3|",5575,0,"PREDICTED: Bos taurus Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (RASSF8), transcript variant X1, mRNA","Q8NHQ8",719,0,"Ras association domain-containing protein 8",".",".",".",".","pfam00788","RA","Ras association (RalGDS/AF-6) domain. RasGTP effectors (in cases of AF6, canoe and RalGDS); putative RasGTP effectors in other cases. Recent evidence (not yet in MEDLINE) shows that some RA domains do NOT bind RasGTP. Predicted structure similar to that determined, and that of the RasGTP-binding domain of Raf kinase.","GO:0034334|adherens junction maintenance;GO:0007165|signal transduction;",".",".","K09855","RASSF7_8; Ras association domain-containing protein 7/8"]
["gene7137",20,13,10,12.5440109024909,76,50,73,73.10677416061,0.171584795615966,-2.54300637574031,0.000249757689401989,0.00601475754179149,"down","yes","BCAT1","protein_coding","chrNC_037332.1:85057073-85181036:+","gi|741927452|ref|XP_005206990.2|",2062,0,"PREDICTED: branched-chain-amino-acid aminotransferase, cytosolic isoform X1 [Bos taurus]","gi|982926630|ref|XM_005206934.3|",3108,0,"PREDICTED: Bos taurus branched chain amino-acid transaminase 1, cytosolic (BCAT1), transcript variant X3, mRNA","Q9GKM4",785,0,"Branched-chain-amino-acid aminotransferase, cytosolic","YJR148w",333,{"v":5e-100,"d":"5.00E-100"},"COG0115","pfam01063","Aminotran_4","Aminotransferase class IV. The D-amino acid transferases (D-AAT) are required by bacteria to catalyse the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.","GO:0009082|branched-chain amino acid biosynthetic process;","GO:0005737|cytoplasm;","GO:0052656|L-isoleucine transaminase activity;GO:0052654|L-leucine transaminase activity;GO:0052655|L-valine transaminase activity;","K00826","E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]"]
["gene7154",6687,1464,7341,4477.14617939927,13811,8699,11680,12570.6992933165,0.35615728886138,-1.48941357912857,0.000849323771059932,0.0159736694212992,"down","yes","LDHB","protein_coding","chrNC_037332.1:88544523-88562770:+","gi|927131538|ref|XP_013843801.1|",1848,0,"PREDICTED: L-lactate dehydrogenase B chain [Sus scrofa]","gi|938326184|ref|NM_174100.2|",1353,0,"Bos taurus lactate dehydrogenase B (LDHB), transcript variant 1, mRNA","Q5E9B1",680,0,"L-lactate dehydrogenase B chain","CAC0267",270,{"v":2e-85,"d":"2.00E-85"},"COG0039","pfam00056","Ldh_1_N","lactate/malate dehydrogenase, NAD binding domain. L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.","GO:0005975|carbohydrate metabolic process;GO:0019752|carboxylic acid metabolic process;","GO:0005829|cytosol;GO:0045121|membrane raft;GO:0043209|myelin sheath;","GO:0042802|identical protein binding;GO:0004459|L-lactate dehydrogenase activity;","K00016","LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]"]
["gene7191",225,300,350,264.448103812961,474,590,520,581.394642447093,0.454851291198518,-1.13653314631809,0.000426413215784882,0.00933691132736644,"down","yes","MGST1","protein_coding","chrNC_037332.1:93495438-93520998:-","gi|528950534|ref|XP_005207031.1|",765,{"v":1e-91,"d":"1.00E-91"},"PREDICTED: microsomal glutathione S-transferase 1 isoform X1 [Bos taurus]","gi|982926710|ref|XM_005206974.2|",2604,0,"PREDICTED: Bos taurus microsomal glutathione S-transferase 1 (MGST1), transcript variant X1, mRNA","Q64L89",291,{"v":2e-90,"d":"2.00E-90"},"Microsomal glutathione S-transferase 1",".",".",".",".","pfam01124","MAPEG","MAPEG family. This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolizm). It includes proteins such as Prostaglandin E synthase. This enzyme catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.","GO:0070207|protein homotrimerization;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0005741|mitochondrial outer membrane;","GO:0004364|glutathione transferase activity;","K00799","GST, gst; glutathione S-transferase [EC:2.5.1.18]"]
["gene7278",1,0,0,0.260623236836211,8,24,18,18.2953583693841,0.014245320128429,-6.1333681467365,0.00039721640001377,0.00876487324732627,"down","yes","LOC101905165","protein_coding","chrNC_037332.1:99362781-99373838:-","gi|982926810|ref|XP_015326746.1|",719,{"v":8e-84,"d":"8.00E-84"},"PREDICTED: T-cell surface glycoprotein YE1/48-like [Bos taurus]","gi|982982273|ref|XM_015463459.1|",1014,0,"PREDICTED: Bos taurus T-cell surface glycoprotein YE1/48-like (LOC101904903), mRNA","Q49BZ4",81.6,{"v":2e-15,"d":"2.00E-15"},"C-type lectin domain family 7 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0006954|inflammatory response;GO:0045087|innate immune response;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0030246|carbohydrate binding;GO:0046872|metal ion binding;","K10074","CLEC7A; C-type lectin domain family 7 member A"]
["gene7292",3147,1004,2100,1794.16530682399,5015,3611,4615,4865.52896410979,0.368750308560182,-1.43928383831722,{"v":1.04701111480462e-05,"d":"1.05E-05"},0.000447189732282794,"down","yes","GABARAPL1","protein_coding","chrNC_037332.1:99764522-99773990:-","gi|744582851|ref|XP_010984496.1|",642,{"v":1e-75,"d":"1.00E-75"},"PREDICTED: gamma-aminobutyric acid receptor-associated protein-like 1 [Camelus dromedarius]","gi|75812927|ref|NM_001033616.1|",1909,0,"Bos taurus GABA(A) receptor-associated protein like 1 (GABARAPL1), mRNA","Q5BIZ2",240,{"v":2e-74,"d":"2.00E-74"},"Gamma-aminobutyric acid receptor-associated protein-like 1",".",".",".",".","pfam02991","Atg8","Autophagy protein Atg8 ubiquitin like. Light chain 3 is proposed to function primarily as a subunit of microtubule associated proteins 1A and 1B and that its expression may regulate microtubule binding activity. Autophagy is generally known as a process involved in the degradation of bulk cytoplasmic components that are non-specifically sequestered into an autophagosome, where they are sequestered into double-membrane vesicles and delivered to the degradative organelle, the lysosome/vacuole, for breakdown and eventual recycling of the resulting macromolecules. The yeast proteins are involved in the autophagosome, and Atg8 binds Atg19, via its N-terminus and the C-terminus of Atg19.","GO:0000045|autophagosome assembly;GO:0000422|mitophagy;GO:0006995|cellular response to nitrogen starvation;","GO:0000421|autophagosome membrane;GO:0005829|cytosol;GO:0005783|endoplasmic reticulum;GO:0005794|Golgi apparatus;GO:0005874|microtubule;",".","K08341","GABARAP, ATG8, LC3; GABA(A) receptor-associated protein"]
["gene7300",38,7,31,21.7184773960733,88,53,85,83.0246286112359,0.261590780463113,-1.93461639967267,0.00178935506958761,0.0283622719391134,"down","yes","CLEC12A","protein_coding","chrNC_037332.1:99947392-99963231:+","gi|982926830|ref|XP_015326751.1|",1230,{"v":1e-156,"d":"1.00E-156"},"PREDICTED: C-type lectin domain family 12 member A isoform X1 [Bos taurus]","gi|982926831|ref|XM_015471266.1|",1980,0,"PREDICTED: Bos taurus C-type lectin domain family 12 member A (CLEC12A), transcript variant X2, mRNA","Q5QGZ9",213,{"v":2e-60,"d":"2.00E-60"},"C-type lectin domain family 12 member A",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0043312|neutrophil degranulation;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0035579|specific granule membrane;GO:0070821|tertiary granule membrane;","GO:0030246|carbohydrate binding;","K17516","CLEC12A; C-type lectin domain family 12 member A"]
["gene7426",0,0,0,0,16,8,6,11.0820273255931,{"$error":"#NAME?"},{"$error":"#NAME?"},0.00206822180231228,0.0315763326583654,"down","yes","PIANP","protein_coding","chrNC_037332.1:103744461-103750919:+","gi|139948710|ref|NP_001077236.1|",900,{"v":5e-111,"d":"5.00E-111"},"PILR alpha-associated neural protein precursor [Bos taurus]","gi|139948709|ref|NM_001083767.1|",2096,0,"Bos taurus PILR alpha associated neural protein (PIANP), mRNA","Q6P1B3",343,{"v":7e-110,"d":"7.00E-110"},"PILR alpha-associated neural protein",".",".",".",".","pfam15298","AJAP1_PANP_C","AJAP1/PANP C-terminus. This family includes the C-terminus of adherens junction-associated protein 1 (AJAP1) and of PILR-associating neural protein (PANP). AJAP1 inhibits cell adhesion and migration. PANP is a ligand for the immune inhibitory receptor paired immunoglobulin-like type 2 receptor alpha.",".","GO:0005912|adherens junction;GO:0016323|basolateral plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["gene7511",49,36,31,34.0891456982628,171,80,139,143.448580435771,0.237640174581763,-2.07314934136493,0.000462226377423083,0.00994047957283167,"down","yes","NINJ2","protein_coding","chrNC_037332.1:107436493-107509080:-","gi|741928150|ref|XP_010803935.1|",557,{"v":7e-66,"d":"7.00E-66"},"PREDICTED: ninjurin-2 isoform X1 [Bos taurus]","gi|982927096|ref|XM_010805633.2|",1365,0,"PREDICTED: Bos taurus ninjurin 2 (NINJ2), transcript variant X2, mRNA","Q9NZG7",139,{"v":1e-37,"d":"1.00E-37"},"Ninjurin-2",".",".",".",".","pfam04923","Ninjurin","Ninjurin. Ninjurin (nerve injury-induced protein) is involved in nerve regeneration and in the formation and function in some tissues.","GO:0007399|nervous system development;GO:0007158|neuron cell-cell adhesion;GO:0042246|tissue regeneration;","GO:0005887|integral component of plasma membrane;",".",".","."]
["gene7671",5,2,6,3.80128134424285,54,37,52,52.5326071221617,0.0723604167484621,-3.78865547281601,{"v":2.50889084566091e-05,"d":"2.51E-05"},0.000906323265262789,"down","yes","MEI1","protein_coding","chrNC_037332.1:112755748-112811605:+","gi|821324753|ref|NP_001295589.1|",5863,0,"meiosis inhibitor protein 1 [Bos taurus]","gi|821324752|ref|NM_001308660.1|",3992,0,"Bos taurus meiotic double-stranded break formation protein 1 (MEI1), mRNA","Q5TIA1",1875,0,"Meiosis inhibitor protein 1",".",".",".",".","pfam01500","Keratin_B2","Keratin, high sulfur B2 protein. High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.","GO:0007141|male meiosis I;GO:0007127|meiosis I;GO:0045141|meiotic telomere clustering;GO:0007286|spermatid development;","GO:0005623|cell;",".",".","."]
["gene7890",9654,1587,18587,8744.61448919143,47586,28358,41682,43239.2337574486,0.202237961436701,-2.30587426858557,{"v":8.15752494318201e-05,"d":"8.16E-05"},0.00245922017185198,"down","yes","MYOZ2","protein_coding","chrNC_037333.1:6097584-6136039:-","gi|62752057|ref|NP_001015676.1|",1164,{"v":3e-156,"d":"3.00E-156"},"myozenin-2 [Bos taurus]","gi|982927752|ref|XM_005207588.3|",1245,0,"PREDICTED: Bos taurus myozenin 2 (MYOZ2), transcript variant X1, mRNA","Q5E9V3",452,{"v":1e-157,"d":"1.00E-157"},"Myozenin-2",".",".",".",".","pfam05556","Calsarcin","Calcineurin-binding protein (Calsarcin). This family consists of several mammalian calcineurin-binding proteins. The calcium- and calmodulin-dependent protein phosphatase calcineurin has been implicated in the transduction of signals that control the hypertrophy of cardiac muscle and slow fibre gene expression in skeletal muscle. Calsarcin-1 and calsarcin-2 are expressed in developing cardiac and skeletal muscle during embryogenesis, but calsarcin-1 is expressed specifically in adult cardiac and slow-twitch skeletal muscle, whereas calsarcin-2 is restricted to fast skeletal muscle. Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. Calsarcin-3, is expressed specifically in skeletal muscle and is enriched in fast-twitch muscle fibres. Like calsarcin-1 and calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin.","GO:0030239|myofibril assembly;","GO:0015629|actin cytoskeleton;GO:0030018|Z disc;","GO:0003779|actin binding;GO:0051373|FATZ binding;GO:0031433|telethonin binding;",".","."]
["gene7937",98,19,26,39.7528755886846,133,136,88,131.387079561039,0.302563050503123,-1.72469228086455,0.00376964283375656,0.0487762719682125,"down","yes","ALPK1","protein_coding","chrNC_037333.1:13097988-13219924:-","gi|528952327|ref|XP_005207724.1|",6159,0,"PREDICTED: alpha-protein kinase 1 isoform X1 [Bos taurus]","gi|742196694|ref|XM_010858524.1|",4434,0,"PREDICTED: Bison bison bison alpha-kinase 1 (ALPK1), transcript variant X7, mRNA","Q96QP1",1779,0,"Alpha-protein kinase 1",".",".",".",".","pfam02816","Alpha_kinase","Alpha-kinase family. This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.",".","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0004674|protein serine/threonine kinase activity;","K08868","ALPK; alpha-kinase"]
["gene7943",91,54,54,57.9980374440887,252,122,146,191.664083857476,0.302602533958406,-1.72450402632174,0.00309018330197001,0.0422548661880803,"down","yes","FAM241A","protein_coding","chrNC_037333.1:13332380-13375661:-","gi|116004139|ref|NP_001070429.1|",508,{"v":8e-57,"d":"8.00E-57"},"uncharacterized protein C4orf32 homolog [Bos taurus]","gi|402693104|ref|NM_001076961.2|",2488,0,"Bos taurus chromosome 6 open reading frame, human C4orf32 (C6H4orf32), mRNA","Q17QE0",200,{"v":3e-58,"d":"3.00E-58"},"Uncharacterized protein FAM241A",".",".",".",".","pfam15378","DUF4605","Domain of unknown function (DUF4605). This protein family is a domain of unknown function, which is found in eukaryotes. Proteins in this family are typically between 82 and 137 amino acids in length.",".","GO:0005794|Golgi apparatus;GO:0016021|integral component of membrane;",".",".","."]
["gene7957",165,167,143,141.650080111434,436,409,421,465.030389076107,0.304603921461682,-1.71499357973023,{"v":2.68573275614054e-06,"d":"2.69E-06"},0.00013856535491039,"down","yes","ELOVL6","protein_coding","chrNC_037333.1:15228080-15362449:+","gi|440905675|gb|ELR56026.1|",1419,{"v":1e-180,"d":"1.00E-180"},"Elongation of very long chain fatty acids protein 6, partial [Bos mutus]","gi|982927811|ref|XM_015471503.1|",4748,0,"PREDICTED: Bos taurus ELOVL fatty acid elongase 6 (ELOVL6), transcript variant X2, mRNA","Q9H5J4",520,{"v":2e-170,"d":"2.00E-170"},"Elongation of very long chain fatty acids protein 6",".",".",".",".","pfam01151","ELO","GNS1/SUR4 family. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.","GO:0034625|fatty acid elongation, monounsaturated fatty acid;GO:0034626|fatty acid elongation, polyunsaturated fatty acid;GO:0019367|fatty acid elongation, saturated fatty acid;GO:0042759|long-chain fatty acid biosynthetic process;GO:0035338|long-chain fatty-acyl-CoA biosynthetic process;GO:0045540|regulation of cholesterol biosynthetic process;GO:0030148|sphingolipid biosynthetic process;GO:0042761|very long-chain fatty acid biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0009922|fatty acid elongase activity;","K10203","ELOVL6; elongation of very long chain fatty acids protein 6 [EC:2.3.1.199]"]
["gene8001",737,650,906,683.348017081513,1427,1168,1259,1416.47341183613,0.482429116827339,-1.05161111170671,0.000289645178564821,0.00681275069219531,"down","yes","PPA2","protein_coding","chrNC_037333.1:19708720-19805622:+","gi|528952300|ref|XP_005207716.1|",1748,0,"PREDICTED: inorganic pyrophosphatase 2, mitochondrial isoform X1 [Bos taurus]","gi|742158814|ref|XM_010848347.1|",1246,0,"PREDICTED: Bison bison bison pyrophosphatase (inorganic) 2 (PPA2), mRNA","Q9H2U2",570,0,"Inorganic pyrophosphatase 2, mitochondrial","YBR011c",293,{"v":2e-95,"d":"2.00E-95"},"COG0221","pfam00719","Pyrophosphatase","Inorganic pyrophosphatase.","GO:0071344|diphosphate metabolic process;GO:0051881|regulation of mitochondrial membrane potential;GO:0006418|tRNA aminoacylation for protein translation;","GO:0005759|mitochondrial matrix;","GO:0004427|inorganic diphosphatase activity;GO:0000287|magnesium ion binding;GO:0004722|protein serine/threonine phosphatase activity;","K01507","ppa; inorganic pyrophosphatase [EC:3.6.1.1]"]
["gene8114",219,121,187,154.162073535843,421,453,464,491.093154962359,0.313916152115089,-1.67154883220872,{"v":3.81783434805248e-06,"d":"3.82E-06"},0.000186838133420729,"down","yes","ABCG2","protein_coding","chrNC_037333.1:36475491-36603215:+","gi|528952655|ref|XP_005207851.1|",3353,0,"PREDICTED: ATP-binding cassette sub-family G member 2 isoform X1 [Bos taurus]","gi|982928102|ref|XM_010806034.2|",1348,0,"PREDICTED: Bos taurus ATP binding cassette subfamily G member 2 (Junior blood group) (ABCG2), transcript variant X7, mRNA","Q4GZT4",1288,0,"ATP-binding cassette sub-family G member 2",".",".",".",".","pfam01061","ABC2_membrane","ABC-2 type transporter.","GO:0033344|cholesterol efflux;GO:0006855|drug transmembrane transport;","GO:0016324|apical plasma membrane;GO:0016021|integral component of membrane;GO:0031966|mitochondrial membrane;GO:0043235|receptor complex;","GO:0005524|ATP binding;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;",".","."]
["gene8194",167,74,173,120.907231427137,314,224,277,299.557885873237,0.403618923516842,-1.30893427865939,0.000712620324387559,0.0139833359526145,"down","yes","ARAP2","protein_coding","chrNC_037333.1:55443414-55641572:-","gi|555949051|ref|XP_005886740.1|",8805,0,"PREDICTED: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [Bos mutus]","gi|926693795|ref|XM_013964575.1|",6798,0,"PREDICTED: Capra hircus ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 (ARAP2), transcript variant X1, mRNA","Q8WZ64",2903,0,"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2","SPBC17G9.08c_2",72.4,{"v":1e-12,"d":"1.00E-12"},"COG5347","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0051056|regulation of small GTPase mediated signal transduction;GO:0007165|signal transduction;","GO:0005829|cytosol;","GO:0005096|GTPase activator activity;GO:0046872|metal ion binding;GO:0005547|phosphatidylinositol-3,4,5-trisphosphate binding;","K18440","ARAP2; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2"]
["gene8228",0,38,49,27.5022318566475,349,303,394,383.865614928903,0.0716454685886394,-3.80298072955014,{"v":3.99314412456415e-09,"d":"3.99E-09"},{"v":4.57543755092128e-07,"d":"4.58E-07"},"down","yes","KLB","protein_coding","chrNC_037333.1:58528467-58563083:+","gi|296486624|tpg|DAA28737.1|",5552,0,"TPA: klotho beta [Bos taurus]","gi|328927045|ref|NM_001205326.1|",5782,0,"Bos taurus klotho beta (KLB), mRNA","Q86Z14",1885,0,"Beta-klotho","BH1923",225,{"v":2e-62,"d":"2.00E-62"},"COG2723","pfam00232","Glyco_hydro_1","Glycosyl hydrolase family 1.","GO:0005975|carbohydrate metabolic process;GO:0008543|fibroblast growth factor receptor signaling pathway;GO:1901657|glycosyl compound metabolic process;GO:0000165|MAPK cascade;GO:0008284|positive regulation of cell proliferation;GO:0090080|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway;GO:0051897|positive regulation of protein kinase B signaling;","GO:0005887|integral component of plasma membrane;GO:0005622|intracellular;GO:0005886|plasma membrane;","GO:0016303|1-phosphatidylinositol-3-kinase activity;GO:0017134|fibroblast growth factor binding;GO:0005104|fibroblast growth factor receptor binding;GO:0004553|hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0046934|phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0005088|Ras guanyl-nucleotide exchange factor activity;",".","."]
["gene8249",298,272,191,225.465165340531,990,492,849,857.054275522644,0.263069879912843,-1.92648201775531,{"v":1.14154183829939e-05,"d":"1.14E-05"},0.000481083163789066,"down","yes","UCHL1","protein_coding","chrNC_037333.1:60147511-60159287:+","gi|114051423|ref|NP_001039637.1|",1264,{"v":5e-172,"d":"5.00E-172"},"ubiquitin carboxyl-terminal hydrolase isozyme L1 [Bos taurus]","gi|402765938|ref|NM_001046172.2|",1137,0,"Bos taurus ubiquitin C-terminal hydrolase L1 (UCHL1), mRNA","P23356",491,{"v":2e-173,"d":"2.00E-173"},"Ubiquitin carboxyl-terminal hydrolase isozyme L1",".",".",".",".","pfam01088","Peptidase_C12","Ubiquitin carboxyl-terminal hydrolase, family 1.","GO:0007628|adult walking behavior;GO:0007412|axon target recognition;GO:0019896|axon transport of mitochondrion;GO:0008283|cell proliferation;GO:0042755|eating behavior;GO:0048747|muscle fiber development;GO:0043407|negative regulation of MAP kinase activity;GO:0050905|neuromuscular process;GO:0016579|protein deubiquitination;GO:0002931|response to ischemia;GO:0006511|ubiquitin-dependent protein catabolic process;","GO:1904115|axon cytoplasm;GO:0005737|cytoplasm;GO:0005829|cytosol;GO:0005789|endoplasmic reticulum membrane;GO:0043209|myelin sheath;GO:0044306|neuron projection terminus;GO:0043025|neuronal cell body;GO:0005654|nucleoplasm;GO:0005886|plasma membrane;","GO:0031694|alpha-2A adrenergic receptor binding;GO:0004197|cysteine-type endopeptidase activity;GO:0016874|ligase activity;GO:0008242|omega peptidase activity;GO:0004843|ubiquitin-specific protease activity;GO:0043130|ubiquitin binding;GO:0031625|ubiquitin protein ligase binding;","K05611","UCHL1; ubiquitin carboxyl-terminal hydrolase L1 [EC:3.4.19.12]"]
["gene8262",16,14,26,16.7431817720823,408,135,362,332.712888229081,0.0503232136909412,-4.31263213266207,{"v":1.09340622352383e-11,"d":"1.09E-11"},{"v":2.15144641126609e-09,"d":"2.15E-09"},"down","yes","SHISA3","protein_coding","chrNC_037333.1:61227897-61232482:+","gi|329664020|ref|NP_001192340.1|",990,{"v":6e-128,"d":"6.00E-128"},"protein shisa-3 homolog precursor [Bos taurus]","gi|329664019|ref|NM_001205411.1|",1739,0,"Bos taurus shisa family member 3 (SHISA3), mRNA","Q3UPR0",374,{"v":7e-125,"d":"7.00E-125"},"Protein shisa-3 homolog",".",".",".",".","pfam13908","Shisa","Wnt and FGF inhibitory regulator. Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.","GO:0007275|multicellular organismal development;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;",".",".","."]
["gene8273",206,113,173,143.852527152806,522,295,336,424.655166448685,0.338751388228286,-1.56170123613757,0.000863301718205298,0.0161513844735183,"down","yes","GNPDA2","protein_coding","chrNC_037333.1:63317744-63348591:-","gi|528952981|ref|XP_005207973.1|",1840,0,"PREDICTED: glucosamine-6-phosphate isomerase 2 isoform X1 [Bos taurus]","gi|982928329|ref|XM_005207916.3|",2370,0,"PREDICTED: Bos taurus glucosamine-6-phosphate deaminase 2 (GNPDA2), transcript variant X1, mRNA","Q17QL1",580,0,"Glucosamine-6-phosphate isomerase 2","PM0875",343,{"v":1e-110,"d":"1.00E-110"},"COG0363","pfam01182","Glucosamine_iso","Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase.","GO:0005975|carbohydrate metabolic process;GO:0006044|N-acetylglucosamine metabolic process;","GO:0005737|cytoplasm;","GO:0004342|glucosamine-6-phosphate deaminase activity;","K02564","nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6]"]
["gene8308",25,25,13,18.7011041379754,94,84,87,97.3657975679244,0.192070568979102,-2.38029162346751,0.000103188675539291,0.00297081342261505,"down","yes","LRRC66","protein_coding","chrNC_037333.1:67852557-67878695:-","gi|300794243|ref|NP_001179375.1|",4335,0,"leucine-rich repeat-containing protein 66 precursor [Bos taurus]","gi|982928381|ref|XM_010806129.2|",4700,0,"PREDICTED: Bos taurus leucine rich repeat containing 66 (LRRC66), transcript variant X3, mRNA","Q68CR7",838,0,"Leucine-rich repeat-containing protein 66",".",".",".",".","pfam13855","LRR_8","Leucine rich repeat.","GO:0019221|cytokine-mediated signaling pathway;GO:0046426|negative regulation of JAK-STAT cascade;GO:0006469|negative regulation of protein kinase activity;","GO:0005737|cytoplasm;GO:0016021|integral component of membrane;","GO:0004860|protein kinase inhibitor activity;",".","."]
["gene8473",17,0,28,13.0300007672424,600,189,461,460.03000622688,0.0283242410079141,-5.14181889246818,{"v":4.22177964103586e-05,"d":"4.22E-05"},0.00139735028930852,"down","yes","ENAM","protein_coding","chrNC_037333.1:86003020-86025077:+","gi|194667929|ref|XP_605463.4|",5318,0,"PREDICTED: enamelin [Bos taurus]","gi|982983396|ref|XM_605463.7|",8115,0,"PREDICTED: Bos taurus enamelin (ENAM), mRNA","O97939",1543,0,"Enamelin",".",".",".",".","pfam15362","Enamelin","Enamelin. ENAMELIN is involved in the mineralisation and structural organisation of enamel. It is necessary for the extension of enamel during the secretory stage of dental enamel formation. The proteins are expressed in teeth, particularly in odontoblasts, ameloblasts and cementoblasts.","GO:0031214|biomineral tissue development;","GO:0005576|extracellular region;",".",".","."]
["gene8538",22,15,11,14.0278143681846,120,16,112,91.1529354327803,0.15389317197063,-2.69999887220525,0.00107979316821959,0.0191828012966832,"down","yes","CXCL10","protein_coding","chrNC_037333.1:90881993-90884345:-","gi|114052749|ref|NP_001040016.1|",511,{"v":1e-60,"d":"1.00E-60"},"C-X-C motif chemokine 10 precursor [Bos taurus]","gi|402743839|ref|NM_001046551.2|",1171,0,"Bos taurus chemokine (C-X-C motif) ligand 10 (CXCL10), mRNA","Q2KIQ8",201,{"v":5e-62,"d":"5.00E-62"},"C-X-C motif chemokine 10",".",".",".",".","pfam00048","IL8","Small cytokines (intecrine/chemokine), interleukin-8 like. Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.","GO:0071222|cellular response to lipopolysaccharide;GO:0070098|chemokine-mediated signaling pathway;GO:0006935|chemotaxis;GO:0051607|defense response to virus;GO:0042118|endothelial cell activation;GO:0007186|G-protein coupled receptor signaling pathway;GO:0006955|immune response;GO:0006954|inflammatory response;GO:0045662|negative regulation of myoblast differentiation;GO:1901740|negative regulation of myoblast fusion;GO:0030816|positive regulation of cAMP metabolic process;GO:0043950|positive regulation of cAMP-mediated signaling;GO:0002690|positive regulation of leukocyte chemotaxis;GO:0090026|positive regulation of monocyte chemotaxis;GO:0051281|positive regulation of release of sequestered calcium ion into cytosol;GO:2000406|positive regulation of T cell migration;GO:0042127|regulation of cell proliferation;GO:1901509|regulation of endothelial tube morphogenesis;GO:0010819|regulation of T cell chemotaxis;GO:0032496|response to lipopolysaccharide;GO:0010818|T cell chemotaxis;","GO:0009897|external side of plasma membrane;GO:0005615|extracellular space;","GO:0008009|chemokine activity;GO:0048248|CXCR3 chemokine receptor binding;GO:0008201|heparin binding;","K12671","CXCL10, IP10; C-X-C motif chemokine 10"]
["gene8563",1467,331,1118,834.170826629962,4259,1979,3466,3569.27872650647,0.23370851383367,-2.09721780346288,0.000438285295476573,0.00953103488204429,"down","yes","FRAS1","protein_coding","chrNC_037333.1:92954024-93295487:+","gi|555956225|ref|XP_005890262.1|",20867,0,"PREDICTED: LOW QUALITY PROTEIN: extracellular matrix protein FRAS1 [Bos mutus]","gi|742150290|ref|XM_010845896.1|",13546,0,"PREDICTED: Bison bison bison Fraser extracellular matrix complex subunit 1 (FRAS1), mRNA","Q86XX4",7220,0,"Extracellular matrix protein FRAS1",".",".",".",".","pfam03302","VSP","Giardia variant-specific surface protein.","GO:0007154|cell communication;GO:0030326|embryonic limb morphogenesis;GO:0003338|metanephros morphogenesis;GO:0002009|morphogenesis of an epithelium;GO:0015031|protein transport;GO:0060021|palate development;GO:0043588|skin development;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0061618|sublamina densa;","GO:0046872|metal ion binding;",".","."]
["gene8601",72,21,227,95.3635551445848,402,250,391,383.142063886902,0.248898683107618,-2.0063694976706,0.000288356375430941,0.00678803279490113,"down","yes","SCD5","protein_coding","chrNC_037333.1:97461663-97637658:-","gi|116004103|ref|NP_001070413.1|",1634,0,"stearoyl-CoA desaturase 5 [Bos taurus]","gi|116004102|ref|NM_001076945.1|",2563,0,"Bos taurus stearoyl-CoA desaturase 5 (SCD5), mRNA","Q2KIA4",634,0,"Stearoyl-CoA desaturase 5","SPCC1281.06c_1",193,{"v":1e-53,"d":"1.00E-53"},"COG1398","pfam00487","FA_desaturase","Fatty acid desaturase.","GO:1903966|monounsaturated fatty acid biosynthetic process;GO:0006636|unsaturated fatty acid biosynthetic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;GO:0016491|oxidoreductase activity;GO:0004768|stearoyl-CoA 9-desaturase activity;","K00507","SCD, desC; stearoyl-CoA desaturase (delta-9 desaturase) [EC:1.14.19.1]"]
["gene8622",179,172,160,152.158461594512,732,327,552,592.860211501073,0.256651498351119,-1.96211741175006,{"v":4.00966237888267e-05,"d":"4.01E-05"},0.0013458785568459,"down","yes","ABRAXAS1","protein_coding","chrNC_037333.1:98232743-98250555:-","gi|741930534|ref|XP_010804587.1|",2199,0,"PREDICTED: BRCA1-A complex subunit Abraxas isoform X1 [Bos taurus]","gi|965943167|ref|XM_012180286.2|",1969,0,"PREDICTED: Ovis aries family with sequence similarity 175 member A (FAM175A), transcript variant X2, mRNA","Q5E9P1",793,0,"BRCA1-A complex subunit Abraxas 1",".",".",".",".","pfam09728","Taxilin","Myosin-like coiled-coil protein. Taxilin contains an extraordinarily long coiled-coil domain in its C-terminal half and is ubiquitously expressed. It is a novel binding partner of several syntaxin family members and is possibly involved in Ca2+-dependent exocytosis in neuroendocrine cells. Gamma-taxilin, described as leucine zipper protein Factor Inhibiting ATF4-mediated Transcription (FIAT), localizes to the nucleus in osteoblasts and dimerises with ATF4 to form inactive dimers, thus inhibiting ATF4-mediated transcription.","GO:0006325|chromatin organization;GO:0006302|double-strand break repair;GO:0045739|positive regulation of DNA repair;GO:0010212|response to ionizing radiation;GO:0072425|signal transduction involved in G2 DNA damage checkpoint;","GO:0070531|BRCA1-A complex;GO:0016604|nuclear body;GO:0005634|nucleus;","GO:0031593|polyubiquitin binding;",".","."]
["gene8623",323,363,472,348.104234113113,3518,1281,2637,2736.9127239971,0.127188649846578,-2.97495816279234,{"v":2.76309110974384e-11,"d":"2.76E-11"},{"v":5.05344567000651e-09,"d":"5.05E-09"},"down","yes","GPAT3","protein_coding","chrNC_037333.1:98288642-98360326:+","gi|300795599|ref|NP_001179443.1|",2246,0,"glycerol-3-phosphate acyltransferase 3 [Bos taurus]","gi|982928774|ref|XM_005208184.3|",2788,0,"PREDICTED: Bos taurus glycerol-3-phosphate acyltransferase 3 (GPAT3), transcript variant X1, mRNA","Q53EU6",805,0,"Glycerol-3-phosphate acyltransferase 3","ECU10g0310",157,{"v":4e-40,"d":"4.00E-40"},"COG0204","pfam01553","Acyltransferase","Acyltransferase. This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.","GO:0016024|CDP-diacylglycerol biosynthetic process;GO:0006654|phosphatidic acid biosynthetic process;GO:0032006|regulation of TOR signaling;GO:0019432|triglyceride biosynthetic process;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0003841|1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0004366|glycerol-3-phosphate O-acyltransferase activity;","K13506","GPAT3_4, AGPAT9, AGPAT6; glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15]"]
["gene8627",36,6,46,25.4763377473158,978,167,690,675.903409254791,0.0376922758466397,-4.72958728271262,{"v":2.03231307216943e-06,"d":"2.03E-06"},0.000111507546657819,"down","yes","CDS1","protein_coding","chrNC_037333.1:99411761-99491693:+","gi|528953734|ref|XP_003586270.2|",2226,0,"PREDICTED: LOW QUALITY PROTEIN: phosphatidate cytidylyltransferase 1 [Bos taurus]","gi|982983557|ref|XM_015463822.1|",4151,0,"PREDICTED: Bos taurus CDP-diacylglycerol synthase 1 (CDS1), mRNA","Q92903",842,0,"Phosphatidate cytidylyltransferase 1","SPBC13A2.03",320,{"v":4e-96,"d":"4.00E-96"},"COG0575","pfam01148","CTP_transf_1","Cytidylyltransferase family. The members of this family are integral membrane protein cytidylyltransferases. The family includes phosphatidate cytidylyltransferase EC:2.7.7.41 as well as Sec59 from yeast. Sec59 is a dolichol kinase EC:2.7.1.108.","GO:0016024|CDP-diacylglycerol biosynthetic process;GO:0006655|phosphatidylglycerol biosynthetic process;GO:0006661|phosphatidylinositol biosynthetic process;GO:0007602|phototransduction;GO:0007165|signal transduction;","GO:0005783|endoplasmic reticulum;GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0004142|diacylglycerol cholinephosphotransferase activity;GO:0004605|phosphatidate cytidylyltransferase activity;","K00981","E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]"]
["gene8630",589,508,630,513.474296706581,1600,1033,1426,1491.87444199623,0.344180637627599,-1.53876215609251,{"v":8.41045523869195e-06,"d":"8.41E-06"},0.000374350543549329,"down","yes","ARHGAP24","protein_coding","chrNC_037333.1:100005717-100887285:+","gi|528953702|ref|XP_005208257.1|",3345,0,"PREDICTED: rho GTPase-activating protein 24 isoform X2 [Bos taurus]","gi|982928786|ref|XM_005208200.3|",4202,0,"PREDICTED: Bos taurus Rho GTPase activating protein 24 (ARHGAP24), transcript variant X3, mRNA","Q8N264",1144,0,"Rho GTPase-activating protein 24",".",".",".",".","pfam00620","RhoGAP","RhoGAP domain. GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.","GO:0001525|angiogenesis;GO:0030154|cell differentiation;GO:0051056|regulation of small GTPase mediated signal transduction;GO:0007165|signal transduction;","GO:0042995|cell projection;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0005925|focal adhesion;","GO:0005096|GTPase activator activity;",".","."]
["gene8658",112,180,251,165.266514818476,597,254,498,496.118890813409,0.33311877027604,-1.58589144690568,0.00192790282056143,0.02997547431795,"down","yes","PPP2R2C","protein_coding","chrNC_037333.1:102716696-102883585:+","gi|965943289|ref|XP_004010034.2|",2445,0,"PREDICTED: protein phosphatase 2, regulatory subunit B, gamma isoform X2 [Ovis aries]","gi|982983596|ref|XM_015463829.1|",3929,0,"PREDICTED: Bos taurus protein phosphatase 2 regulatory subunit B, gamma (PPP2R2C), transcript variant X2, mRNA","Q9Y2T4",909,0,"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform","SPAC227.07c",464,{"v":4e-149,"d":"4.00E-149"},"COG5170","pfam00400","WD40","WD domain, G-beta repeat.","GO:0032502|developmental process;GO:0000278|mitotic cell cycle;GO:0070262|peptidyl-serine dephosphorylation;","GO:0005829|cytosol;GO:0000159|protein phosphatase type 2A complex;","GO:0019888|protein phosphatase regulator activity;","K04354","PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B"]
["gene8993",54,17,83,45.1359509251399,157,117,168,162.262580990936,0.278166109829481,-1.84598143402681,0.000556683728507242,0.0114497537622849,"down","yes","KCNN1","protein_coding","chrNC_037334.1:5185082-5223483:-","gi|296486116|tpg|DAA28229.1|",2468,0,"TPA: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 [Bos taurus]","gi|982984094|ref|XM_005198809.3|",2084,0,"PREDICTED: Bos taurus potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 (KCNN1), transcript variant X8, mRNA","Q92952",836,0,"Small conductance calcium-activated potassium channel protein 1",".",".",".",".","pfam03530","SK_channel","Calcium-activated SK potassium channel.","GO:0007268|synaptic transmission;GO:0006813|potassium ion transport;","GO:0043025|neuronal cell body;GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0015269|calcium-activated potassium channel activity;GO:0005516|calmodulin binding;GO:0046982|protein heterodimerization activity;GO:0016286|small conductance calcium-activated potassium channel activity;","K04942","KCNN1; potassium intermediate/small conductance calcium-activated channel subfamily N member 1"]
["gene9229",1095,964,1483,1056.76366973162,2157,1651,2288,2238.02021571138,0.472186829373976,-1.08257029360425,0.000150798761170566,0.00409756138567374,"down","yes","ADGRE5","protein_coding","chrNC_037334.1:11349799-11371529:-","gi|528954781|ref|XP_005208660.1|",4239,0,"PREDICTED: CD97 antigen isoform X1 [Bos taurus]","gi|982929948|ref|XM_005208603.3|",3129,0,"PREDICTED: Bos taurus adhesion G protein-coupled receptor E5 (ADGRE5), transcript variant X1, mRNA","Q8SQA4",1303,0,"CD97 antigen","SPAC17G6.14c",131,{"v":3e-55,"d":"3.00E-55"},"COG0513","pfam00002","7tm_2","7 transmembrane receptor (Secretin family). This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors (GCPRs).They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families are recognized. Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways. Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin, and brain-specific angiogenesis inhibitors amongst others. Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.","GO:0007155|cell adhesion;GO:0007166|cell surface receptor signaling pathway;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0004930|G-protein coupled receptor activity;","K08446","CD97; CD97 antigen"]
["gene9260",255,342,468,322.27129621048,990,495,806,842.633404026123,0.382457299545282,-1.38662941158688,0.00099719383390121,0.0180411777267187,"down","yes","ZSWIM4","protein_coding","chrNC_037334.1:11841988-11864656:-","gi|528906852|ref|XP_005198912.1|",5182,0,"PREDICTED: zinc finger SWIM domain-containing protein 4 isoform X1 [Bos taurus]","gi|982984426|ref|XM_005198855.3|",3168,0,"PREDICTED: Bos taurus zinc finger, SWIM-type containing 4 (ZSWIM4), transcript variant X1, mRNA","Q8C7B8",1796,0,"Zinc finger SWIM domain-containing protein 4","all4744",57.4,{"v":3e-07,"d":"3.00E-07"},"COG4715","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".","GO:0008270|zinc ion binding;",".","."]
["gene9489",195,154,128,140.601622882713,256,356,328,344.731313060236,0.407858577262881,-1.29385910261839,0.000470632910993414,0.010080801489154,"down","yes","CD209","protein_coding","chrNC_037334.1:16586871-16589774:-","gi|224809557|ref|NP_001139228.1|",1343,0,"CD209 antigen [Bos taurus]","gi|224809556|ref|NM_001145756.1|",780,0,"Bos taurus CD209 molecule (CD209), mRNA","Q8HY00",171,{"v":1e-48,"d":"1.00E-48"},"CD209 antigen",".",".",".",".","pfam00059","Lectin_C","Lectin C-type domain. This family includes both long and short form C-type","GO:0002250|adaptive immune response;GO:0007155|cell adhesion;GO:0006897|endocytosis;GO:0045087|innate immune response;","GO:0016021|integral component of membrane;","GO:0005537|mannose binding;GO:0046872|metal ion binding;",".","."]
["gene9599",205,298,498,304.034205491822,555,556,594,625.904274151967,0.485751924132097,-1.04170838434624,0.00223878730422913,0.0334248250010264,"down","yes","PLIN3","protein_coding","chrNC_037334.1:19291317-19311906:+","gi|741932605|ref|XP_010805290.1|",1828,0,"PREDICTED: perilipin-3 isoform X4 [Bos taurus]","gi|982930909|ref|XM_010806988.2|",1204,0,"PREDICTED: Bos taurus perilipin 3 (PLIN3), transcript variant X7, mRNA","Q5BLZ2",545,0,"Perilipin-3",".",".",".",".","pfam03036","Perilipin","Perilipin family. The perilipin family includes lipid droplet-associated protein (perilipin) and adipose differentiation-related protein (adipophilin).",".","GO:0010008|endosome membrane;GO:0005811|lipid particle;",".",".","."]
["gene9670",76,40,49,47.9650332146127,118,136,125,139.136555081036,0.344733511525255,-1.53644654506142,0.00177502398258656,0.0282292136271891,"down","yes","GNA15","protein_coding","chrNC_037334.1:20661236-20685289:-","gi|440912156|gb|ELR61748.1|",1750,0,"Guanine nucleotide-binding protein subunit alpha-15, partial [Bos mutus]","gi|965936824|ref|XM_015095899.1|",3289,0,"PREDICTED: Ovis aries guanine nucleotide binding protein (G protein), alpha 15 (Gq class) (GNA15), transcript variant X1, mRNA","P30679",632,0,"Guanine nucleotide-binding protein subunit alpha-15",".",".",".",".","pfam00503","G-alpha","G-protein alpha subunit. G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA.","GO:0007202|activation of phospholipase C activity;GO:0007188|adenylate cyclase-modulating G-protein coupled receptor signaling pathway;GO:0007186|G-protein coupled receptor signaling pathway;GO:0060158|phospholipase C-activating dopamine receptor signaling pathway;GO:0007207|phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway;GO:0030168|platelet activation;GO:0051482|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;","GO:0005834|heterotrimeric G-protein complex;GO:0005886|plasma membrane;","GO:0031683|G-protein beta/gamma-subunit complex binding;GO:0001664|G-protein coupled receptor binding;GO:0005525|GTP binding;GO:0003924|GTPase activity;GO:0046872|metal ion binding;","K04637","GNA15; guanine nucleotide-binding protein subunit alpha-15"]
["gene979",3064,3227,6266,3780.51870465419,12022,9468,10607,11796.9177112183,0.320466650458966,-1.64175386509745,{"v":5.28274253680302e-06,"d":"5.28E-06"},0.000247490849454067,"down","yes","PFN2","protein_coding","chrNC_037328.1:118211474-118220079:+","gi|119599260|gb|EAW78854.1|",820,{"v":6e-96,"d":"6.00E-96"},"profilin 2, isoform CRA_c, partial [Homo sapiens]","gi|926683972|ref|XM_013965795.1|",2331,0,"PREDICTED: Capra hircus profilin 2 (PFN2), mRNA","Q9JJV2",272,{"v":3e-83,"d":"3.00E-83"},"Profilin-2",".",".",".",".","pfam00235","Profilin","Profilin.","GO:0030036|actin cytoskeleton organization;GO:0030837|negative regulation of actin filament polymerization;GO:0010633|negative regulation of epithelial cell migration;GO:1900028|negative regulation of ruffle assembly;GO:0032233|positive regulation of actin filament bundle assembly;GO:0030838|positive regulation of actin filament polymerization;GO:0032781|positive regulation of ATPase activity;GO:0033138|positive regulation of peptidyl-serine phosphorylation;GO:0051496|positive regulation of stress fiber assembly;GO:0050821|protein stabilization;GO:2000300|regulation of synaptic vesicle exocytosis;","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005829|cytosol;GO:0043195|terminal bouton;","GO:0003779|actin binding;GO:0003785|actin monomer binding;GO:0016887|ATPase activity;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;","K05759","PFN; profilin"]
["gene9801",176,10,301,141.590478191278,839,908,831,946.784610612177,0.149548774456449,-2.741312007184,{"v":1.05958572402705e-08,"d":"1.06E-08"},{"v":1.11143530486087e-06,"d":"1.11E-06"},"down","yes","LOC781423","protein_coding","chrNC_037334.1:31639221-31704946:-","gi|296485584|tpg|DAA27699.1|",2106,0,"TPA: zinc finger protein 474 isoform 1 [Bos taurus]","gi|742151647|ref|XM_010846288.1|",1899,0,"PREDICTED: Bison bison bison zinc finger protein 474 (ZNF474), transcript variant X1, mRNA","A6QQM4",813,0,"Zinc finger protein 474",".",".",".",".","pfam13913","zf-C2HC_2","zinc-finger of a C2HC-type. This family contains a number of divergent C2H2 type zinc fingers.",".",".","GO:0046872|metal ion binding;",".","."]
["gene9863",177,158,235,170.083290132555,373,251,367,364.006427517652,0.467253535308266,-1.09772251523494,0.00200304857502721,0.0308399571167708,"down","yes","PRELID1","protein_coding","chrNC_037334.1:38775907-38779467:+","gi|548473443|ref|XP_005682809.1|",788,{"v":2e-99,"d":"2.00E-99"},"PREDICTED: PRELI domain-containing protein 1, mitochondrial [Capra hircus]","gi|402744940|ref|NM_001038138.2|",960,0,"Bos taurus PRELI domain containing 1 (PRELID1), mRNA","Q32KN9",308,{"v":6e-101,"d":"6.00E-101"},"PRELI domain-containing protein 1, mitochondrial",".",".",".",".","pfam04707","PRELI","PRELI-like family. This family includes a conserved region found in the PRELI protein and yeast YLR168C gene MSF1 product. The function of this protein is unknown, though it is thought to be involved in intra-mitochondrial protein sorting. This region is also found in a number of other eukaryotic proteins.","GO:0006915|apoptotic process;GO:0043066|negative regulation of apoptotic process;GO:0010917|negative regulation of mitochondrial membrane potential;GO:0090201|negative regulation of release of cytochrome c from mitochondria;GO:1901857|positive regulation of cellular respiration;GO:0010950|positive regulation of endopeptidase activity;GO:2001140|positive regulation of phospholipid transport;GO:0070234|positive regulation of T cell apoptotic process;GO:0097035|regulation of membrane lipid distribution;GO:0051881|regulation of mitochondrial membrane potential;GO:0045580|regulation of T cell differentiation;","GO:0005758|mitochondrial intermembrane space;GO:0005654|nucleoplasm;GO:0032991|macromolecular complex;","GO:1990050|phosphatidic acid transporter activity;",".","."]
["gene9870",0,0,0,0,7,61,18,31.5001303318086,{"$error":"#NAME?"},{"$error":"#NAME?"},{"v":7.35782467262822e-06,"d":"7.36E-06"},0.000331113715669962,"down","yes","SLC34A1","protein_coding","chrNC_037334.1:38883084-38896500:+","gi|157073970|ref|NP_001096693.1|",2776,0,"sodium-dependent phosphate transport protein 2A [Bos taurus]","gi|157073969|ref|NM_001103223.1|",2476,0,"Bos taurus solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 (SLC34A1), mRNA","O97704",1033,0,"Sodium-dependent phosphate transport protein 2A","VC0676",83.2,{"v":4e-16,"d":"4.00E-16"},"COG1283","pfam02690","Na_Pi_cotrans","Na+/Pi-cotransporter. This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule.","GO:0055062|phosphate ion homeostasis;GO:0006817|phosphate ion transport;GO:0006814|sodium ion transport;","GO:0016324|apical plasma membrane;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0015321|sodium-dependent phosphate transmembrane transporter activity;GO:0015293|symporter activity;","K14683","SLC34A, NPT, nptA; solute carrier family 34 (sodium-dependent phosphate cotransporter)"]
["id691109",10,49,49,33.7133586962821,225,74,154,166.844725218617,0.2020642765428,-2.30711380835056,0.00250085095862831,0.0361274828863921,"down","yes","IGHG1","protein_coding","chrNC_037347.1:71898763-71910526:+","gi|108750|pir||S22080",1608,0,"Ig heavy chain precursor (B/MT.4A.17.H5.A5) - bovine","gi|151554382|gb|BC147881.1|",982,0,"Bos taurus immunoglobulin heavy constant gamma 1, mRNA (cDNA clone IMAGE:8633450)","P03987",509,{"v":1e-172,"d":"1.00E-172"},"Ig gamma-3 chain C region",".",".",".",".","pfam07654","C1-set","Immunoglobulin C1-set domain.",".","GO:0005576|extracellular region;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0003823|antigen binding;GO:0034987|immunoglobulin receptor binding;",".","."]
["rna78882",32,19,14,18.8662823541974,196,61,167,155.927259756285,0.120994124976514,-3.04699109757776,{"v":1.40283950100909e-05,"d":"1.40E-05"},0.000570148344776216,"down","yes","rna78882","protein_coding","chrNC_006853.1:7304-7372:+",".",".",".",".","gi|946518850|gb|KT184472.1|",69,{"v":5e-27,"d":"5.00E-27"},"Bos taurus isolate 31_EG10 mitochondrion, complete genome",".",".",".",".",".",".",".",".","pfam14214","Helitron_like_N","Helitron helicase-like domain at N-terminus. This family is found in Helitrons, recently recognized eukaryotic transposons that are predicted to amplify by a rolling-circle mechanism. In many instances a protein-coding gene is disrupted by their insertion.",".",".",".",".","."]

{"sheet":"Luxi-specific-mRNA","index":2,"n_rows":72,"n_cols":42,"rows_kept":72,"flags":["formulas_cached_only"]}
["GeneName","Gene","L1_count","L2_count","L3_count","L_normalize","B1_count","B2_count","B3_count","B_normalize","FoldChange","Log2FoldChange","pval","padj","Up/Down","Significant","Biotype","Position","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["HOXA10","gene5277",327,259,0,170.102677359948,0,0,0,0,"Inf","Inf",{"v":1.43279109710621e-34,"d":"1.43E-34"},{"v":3.71626934468521e-31,"d":"3.72E-31"},"up","yes","protein_coding","chrNC_037331.1:68862754-68872133:+","gi|507537641|ref|XP_004652844.1|",542,{"v":5e-73,"d":"5.00E-73"},"PREDICTED: homeobox protein Hox-A10 isoform X2 [Jaculus jaculus]","gi|157279942|ref|NM_001105017.1|",1781,0,"Bos taurus homeobox A10 (HOXA10), mRNA","P31260",201,{"v":4e-56,"d":"4.00E-56"},"Homeobox protein Hox-A10",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009952|anterior/posterior pattern specification;GO:0030326|embryonic limb morphogenesis;GO:0008584|male gonad development;GO:0007275|multicellular organismal development;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0009954|proximal/distal pattern formation;GO:0007338|single fertilization;GO:0001501|skeletal system development;GO:0007283|spermatogenesis;GO:0060065|uterus development;","GO:0005737|cytoplasm;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0042826|histone deacetylase binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K17443","HOXA10; homrobox protein Hox-A10"]
["PRM1","gene29722",0,275,4,91.3508483162451,0,0,0,0,"Inf","Inf",{"v":3.28606002481819e-21,"d":"3.29E-21"},{"v":2.60429384911355e-18,"d":"2.60E-18"},"up","yes","protein_coding","chrNC_037352.1:9936642-9937121:-","gi|926723490|ref|XP_013830076.1|",143,{"v":2e-09,"d":"2.00E-09"},"PREDICTED: sperm protamine P1 [Capra hircus]","gi|742167260|ref|XR_826186.1|",376,0,"PREDICTED: Bison bison bison uncharacterized LOC104996417 (LOC104996417), ncRNA",".",".",".",".",".",".",".",".","pfam00260","Protamine_P1","Protamine P1.",".",".",".",".","."]
["FAM240A","gene4765",223,4,3,60.3512174321258,0,0,0,0,"Inf","Inf",{"v":2.36203537547048e-15,"d":"2.36E-15"},{"v":8.86726727599319e-13,"d":"8.87E-13"},"up","yes","protein_coding","chrNC_037330.1:120881582-120892494:-","gi|440901293|gb|ELR52268.1|",489,{"v":3e-55,"d":"3.00E-55"},"hypothetical protein M91_12507, partial [Bos mutus]","gi|982979930|ref|XR_001496193.1|",388,0,"PREDICTED: Bos taurus uncharacterized LOC101905375 (LOC101905375), transcript variant X3, misc_RNA",".",".",".",".",".",".",".",".","pfam15498","Dendrin","Nephrin and CD2AP-binding protein, Dendrin. Dendrin is a family of eukaryotic proteins found in the podocytes of the kidneys. Dendrin, originally identified in telencephalic dendrites, is a constituent of the slit diaphragm, SD, complex of podocytes, where it directly binds to nephrin and CD2AP. Kidney podocytes and their slit diaphragms (SDs) form the final barrier to urinary protein loss. SD proteins also participate in intracellular signalling pathways. Dendrin appears to prevent programmed cell death (apoptosis) through its binding to nephrin. The SD protein nephrin serves as a component of a signalling complex that directly links podocyte junctional integrity to actin cytoskeletal dynamics. Thus, dendrin is identified as an SD family with proapoptotic signalling properties that accumulates in the podocyte nucleus in response to glomerular injury.",".",".",".",".","."]
["LOC112441513","gene18266",44,85,59,57.4436015362316,0,0,0,0,"Inf","Inf",{"v":2.90317573118404e-15,"d":"2.90E-15"},{"v":1.06192957418477e-12,"d":"1.06E-12"},"up","yes","pseudogene","chrNC_037341.1:76473876-76476882:+","gi|982945226|ref|XP_015330041.1|",982,{"v":1e-121,"d":"1.00E-121"},"PREDICTED: LOW QUALITY PROTEIN: solute carrier family 7 member 13 [Bos taurus]","gi|850485665|gb|CP011894.1|",2224,0,"Ovis canadensis canadensis isolate 43U chromosome 9 sequence","Q8TCU3",199,{"v":2e-53,"d":"2.00E-53"},"Solute carrier family 7 member 13",".",".",".",".","pfam13520","AA_permease_2","Amino acid permease.",".","GO:0005887|integral component of plasma membrane;","GO:0015297|antiporter activity;GO:0015179|L-amino acid transmembrane transporter activity;","K13870","SLC7A13, AGT1; solute carrier family 7 (L-type amino acid transporter), member 13"]
["HOXC11","gene6167",52,107,0,48.6181999905883,0,0,0,0,"Inf","Inf",{"v":4.00085337934668e-13,"d":"4.00E-13"},{"v":1.04723254831321e-10,"d":"1.05E-10"},"up","yes","protein_coding","chrNC_037332.1:26057080-26059552:-","gi|7657166|ref|NP_055027.1|",1394,0,"homeobox protein Hox-C11 [Homo sapiens]","gi|300797720|ref|NM_001192873.1|",1199,0,"Bos taurus homeobox C11 (HOXC11), mRNA","O43248",541,0,"Homeobox protein Hox-C11",".",".",".",".","pfam12045","DUF3528","Protein of unknown function (DUF3528). This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.","GO:0009952|anterior/posterior pattern specification;GO:0042733|embryonic digit morphogenesis;GO:0060272|embryonic skeletal joint morphogenesis;GO:0007492|endoderm development;GO:0001656|metanephros development;GO:0001759|organ induction;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0009954|proximal/distal pattern formation;","GO:0005829|cytosol;GO:0005654|nucleoplasm;","GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0001077|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09296","HOX_11; homeobox protein HoxA/C/D11"]
["C8H9orf131","gene11252",0,115,0,37.687533108758,0,0,0,0,"Inf","Inf",{"v":1.1720888569855e-10,"d":"1.17E-10"},{"v":1.87870040329513e-08,"d":"1.88E-08"},"up","yes","protein_coding","chrNC_037335.1:59313922-59318157:+","gi|528958832|ref|XP_005210189.1|",5706,0,"PREDICTED: uncharacterized protein C9orf131 homolog [Bos taurus]","gi|982986394|ref|XM_003582542.4|",3850,0,"PREDICTED: Bos taurus chromosome 8 open reading frame, human C9orf131 (C8H9orf131), mRNA",".",".",".",".",".",".",".",".","pfam14650","FAM75","FAM75 family.",".",".",".",".","."]
["LCA5L","gene1172",0,105,0,34.4103563166921,0,0,0,0,"Inf","Inf",{"v":6.20023633983235e-10,"d":"6.20E-10"},{"v":8.75737341642361e-08,"d":"8.76E-08"},"up","yes","protein_coding","chrNC_037328.1:139470604-139512514:-","gi|594061460|ref|XP_006054810.1|",3372,0,"PREDICTED: lebercilin-like protein isoform X1 [Bubalus bubalis]","gi|594061463|ref|XM_006054750.1|",2229,0,"PREDICTED: Bubalus bubalis Leber congenital amaurosis 5-like (LCA5L), transcript variant X3, mRNA",".",".",".",".",".",".",".",".","pfam15619","Lebercilin","Ciliary protein causing Leber congenital amaurosis disease. Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.",".",".",".",".","."]
["GSG1","gene7221",0,104,0,34.0826386374855,0,0,0,0,"Inf","Inf",{"v":7.33909457307404e-10,"d":"7.34E-10"},{"v":1.01646459837075e-07,"d":"1.02E-07"},"up","yes","protein_coding","chrNC_037332.1:96766276-96785809:+","gi|982926768|ref|XP_015326740.1|",1865,0,"PREDICTED: germ cell-specific gene 1 protein isoform X1 [Bos taurus]","gi|982926767|ref|XM_015471254.1|",1412,0,"PREDICTED: Bos taurus germ cell associated 1 (GSG1), transcript variant X1, mRNA","Q3SZT1",586,0,"Germ cell-specific gene 1 protein",".",".",".",".","pfam07803","GSG-1","GSG1-like protein. This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumorigenesis of human testicular germ cell tumors. The region in question has four highly-conserved cysteine residues.",".","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0070063|RNA polymerase binding;",".","."]
["LOC616410","gene27365",2,95,3,32.5757908991229,0,0,0,0,"Inf","Inf",{"v":1.56388173022915e-09,"d":"1.56E-09"},{"v":1.99192453773071e-07,"d":"1.99E-07"},"up","yes","protein_coding","chrNC_037349.1:50378405-50382767:+","gi|119914715|ref|XP_873518.2|",6083,0,"PREDICTED: uncharacterized protein LOC616410 [Bos taurus]","gi|50872227|gb|AC149756.4|",4363,0,"Bos taurus BAC CH240-361I2 (Children's Hospital Oakland Research Institute Bovine BAC Library (male)) complete sequence","Q9QY83",295,{"v":5e-87,"d":"5.00E-87"},"Actin-like protein 7B","YFL039c",281,{"v":8e-83,"d":"8.00E-83"},"COG5277","pfam00022","Actin","Actin.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;",".",".","."]
["C25H16orf82","gene29893",0,99,0,32.4440502414526,0,0,0,0,"Inf","Inf",{"v":1.7152149284945e-09,"d":"1.72E-09"},{"v":2.14196429708644e-07,"d":"2.14E-07"},"up","yes","protein_coding","chrNC_037352.1:24671805-24673861:+","gi|942070329|ref|XP_014335371.1|",866,{"v":5e-108,"d":"5.00E-108"},"PREDICTED: protein TNT [Bos mutus]","gi|485464568|ref|NM_001145758.2|",2057,0,"Bos taurus chromosome 25 open reading frame, human C16orf82 (C25H16orf82), mRNA",".",".",".",".",".",".",".",".","pfam03154","Atrophin-1","Atrophin-1 family. Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.",".",".",".",".","."]
["LOC112445398","gene34444",41,26,31,28.7269830115072,0,0,0,0,"Inf","Inf",{"v":5.56436673832748e-09,"d":"5.56E-09"},{"v":6.12961186915912e-07,"d":"6.13E-07"},"up","yes","pseudogene","chrNW_020190209.1:32321-45392:-","gi|119573588|gb|EAW53203.1|",450,{"v":6e-50,"d":"6.00E-50"},"hCG1997137, isoform CRA_b [Homo sapiens]","gi|258597991|gb|GQ452383.1|",456,0,"Bubalus bubalis ribosomal protein SA pseudogene, complete sequence","Q4GWZ2",150,{"v":3e-40,"d":"3.00E-40"},"40S ribosomal protein SA","SPAPJ698.02c",80.1,{"v":8e-30,"d":"8.00E-30"},"COG0052","pfam07919","Gryzun","Gryzun, putative trafficking through Golgi. The proteins featured in this family are all eukaryotic, and many of them are annotated as being Gryzun. Gryzun is distantly related to, but distinct from, the Trs130 subunit of the TRAPP complex but is absent from S. cerevisiae. RNAi of human Gryzun blocks Golgi exit. Thus the family is likely to be involved with trafficking of proteins through membranes, perhaps as part of the TRAPP complex.","GO:0000447|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000461|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000028|ribosomal small subunit assembly;GO:0006407|rRNA export from nucleus;GO:0006412|translation;","GO:0030686|90S preribosome;GO:0098556|cytoplasmic side of rough endoplasmic reticulum membrane;GO:0022627|cytosolic small ribosomal subunit;GO:0005634|nucleus;GO:0005886|plasma membrane;","GO:0005055|laminin receptor activity;GO:0003735|structural constituent of ribosome;GO:0001618|virus receptor activity;","K02998","RP-SAe, RPSA; small subunit ribosomal protein SAe"]
["LOC509034","gene14127",98,0,0,25.5410772099487,0,0,0,0,"Inf","Inf",{"v":6.82649126819937e-08,"d":"6.83E-08"},{"v":5.91995812683879e-06,"d":"5.92E-06"},"up","yes","protein_coding","chrNC_037337.1:86875770-86908135:+","gi|742141685|ref|XP_010842710.1|",2038,0,"PREDICTED: feline leukemia virus subgroup C receptor-related protein 2-like [Bison bison bison]","gi|982990122|ref|XM_015465238.1|",1675,0,"PREDICTED: Bos taurus feline leukemia virus subgroup C receptor-related protein 2 (LOC509034), mRNA","Q9UPI3",681,0,"Feline leukemia virus subgroup C receptor-related protein 2",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.",".","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0020037|heme binding;GO:0015232|heme transporter activity;","K08220","FLVCR, SLC49A1_2; MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein"]
["FSIP2","gene1521",0,71,6,25.1106850253166,0,0,0,0,"Inf","Inf",{"v":8.37136985904014e-08,"d":"8.37E-08"},{"v":7.0901949292977e-06,"d":"7.09E-06"},"up","yes","protein_coding","chrNC_037329.1:10562877-10705291:-","gi|982913018|ref|XP_015330091.1|",34294,0,"PREDICTED: LOW QUALITY PROTEIN: fibrous sheath-interacting protein 2 [Bos taurus]","gi|742201718|ref|XM_010859740.1|",20430,0,"PREDICTED: Bison bison bison fibrous sheath interacting protein 2 (FSIP2), mRNA","Q5CZC0",8491,0,"Fibrous sheath-interacting protein 2",".",".",".",".","pfam13949","ALIX_LYPXL_bnd","ALIX V-shaped domain binding to HIV. The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding.This domain is generally central between an N-terminal Bro1 domain, pfam03097 and a C-terminal proline-rich domain. The retroviruses thus used this domain to hijack the ESCRT system of the cell.",".","GO:0005739|mitochondrion;",".",".","."]
["HDGFL1","gene28685",0,73,0,23.9233905820812,0,0,0,0,"Inf","Inf",{"v":1.67441281795713e-07,"d":"1.67E-07"},{"v":1.30629790997099e-05,"d":"1.31E-05"},"up","yes","protein_coding","chrNC_037350.1:35662146-35664136:-","gi|83721975|ref|NP_001001136.2|",897,{"v":6e-113,"d":"6.00E-113"},"hepatoma-derived growth factor-like protein 1 [Bos taurus]","gi|402744075|ref|NM_001001136.3|",1988,0,"Bos taurus hepatoma derived growth factor-like 1 (HDGFL1), mRNA","P51859",199,{"v":3e-57,"d":"3.00E-57"},"Hepatoma-derived growth factor",".",".",".",".","pfam00855","PWWP","PWWP domain. The PWWP domain is named after a conserved Pro-Trp-Trp-Pro motif. The domain binds to Histone-4 methylated at lysine-20, H4K20me, suggesting that it is methyl-lysine recognition motif. Removal of two conserved aromatic residues in a hydrophobic cavity created by this domain within the full-length protein, Pdp1, abolishes the interaction o f the protein with H4K20me3. In fission yeast, Set9 is the sole enzyme that catalyses all three states of H4K20me, and Set9-mediated H4K20me is required for efficient recruitment of checkpoint protein Crb2 to sites of DNA damage. The methylation of H4K20 is involved in a diverse array of cellular processes, such as organizing higher-order chromatin, maintaining genome stability, and regulating cell-cycle progression.","GO:0009987|cellular process;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0034504|protein localization to nucleus;GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0031012|extracellular matrix;GO:0005576|extracellular region;GO:0005615|extracellular space;GO:0005654|nucleoplasm;GO:0005634|nucleus;GO:0017053|transcriptional repressor complex;","GO:0008083|growth factor activity;GO:0008201|heparin binding;GO:0000166|nucleotide binding;GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001106|RNA polymerase II transcription corepressor activity;GO:0001222|transcription corepressor binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K16641","HDGF; hepatoma-derived growth factor"]
["PGK2","gene28024",0,70,1,23.2473591780695,0,0,0,0,"Inf","Inf",{"v":2.4269963361526e-07,"d":"2.43E-07"},{"v":1.78926698880542e-05,"d":"1.79E-05"},"up","yes","protein_coding","chrNC_037350.1:22503346-22504971:-","gi|555986632|ref|XP_005905175.1|",2189,0,"PREDICTED: phosphoglycerate kinase 2 [Bos mutus]","gi|942082768|ref|XM_005905113.2|",1623,0,"PREDICTED: Bos mutus phosphoglycerate kinase 2 (PGK2), mRNA","Q8MIF7",804,0,"Phosphoglycerate kinase 2","SPBC14F5.04c",561,0,"COG0126","pfam00162","PGK","Phosphoglycerate kinase.","GO:0006096|glycolytic process;GO:0016310|phosphorylation;","GO:0005737|cytoplasm;","GO:0005524|ATP binding;GO:0004618|phosphoglycerate kinase activity;","K00927","PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]"]
["LOC100299869","gene26200",0,23,47,21.9722234013324,0,0,0,0,"Inf","Inf",{"v":3.36969076087606e-07,"d":"3.37E-07"},{"v":2.39752237153503e-05,"d":"2.40E-05"},"up","yes","pseudogene","chrNC_037348.1:27228448-27229378:-","gi|77736039|ref|NP_001029718.1|",1236,{"v":6e-169,"d":"6.00E-169"},"ribosome biogenesis protein NSA2 homolog [Bos taurus]","gi|942038339|ref|XR_001351273.1|",897,0,"PREDICTED: Bos mutus ribosome biogenesis protein NSA2 homolog (LOC102275194), misc_RNA","Q3SX11",480,{"v":2e-170,"d":"2.00E-170"},"Ribosome biogenesis protein NSA2 homolog","SPCP1E11.08",330,{"v":5e-112,"d":"5.00E-112"},"COG2007","pfam01201","Ribosomal_S8e","Ribosomal protein S8e.","GO:0000460|maturation of 5.8S rRNA;GO:0000470|maturation of LSU-rRNA;","GO:0005730|nucleolus;GO:0030687|preribosome, large subunit precursor;",".","K14842","NSA2; ribosome biogenesis protein NSA2"]
["HSPB9","gene24664",0,61,5,21.5263865996426,0,0,0,0,"Inf","Inf",{"v":6.215209770713e-07,"d":"6.22E-07"},{"v":4.05780663542821e-05,"d":"4.06E-05"},"up","yes","protein_coding","chrNC_037346.1:42257571-42258088:+","gi|94966950|ref|NP_001035667.1|",752,{"v":3e-99,"d":"3.00E-99"},"heat shock protein beta-9 [Bos taurus]","gi|402747143|ref|NM_001040577.2|",518,0,"Bos taurus heat shock protein family B (small) member 9 (HSPB9), mRNA","Q2TBQ6",294,{"v":9e-101,"d":"9.00E-101"},"Heat shock protein beta-9",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.",".","GO:0005737|cytoplasm;GO:0005634|nucleus;",".","K09547","HSPB9; heat shock protein beta-9"]
["ODF1","gene18128",0,65,0,21.3016491484285,0,0,0,0,"Inf","Inf",{"v":7.29569159369161e-07,"d":"7.30E-07"},{"v":4.62563059688034e-05,"d":"4.63E-05"},"up","yes","protein_coding","chrNC_037341.1:61844560-61854021:-","gi|594043987|ref|XP_006046499.1|",997,{"v":5e-132,"d":"5.00E-132"},"PREDICTED: outer dense fiber protein 1 [Bubalus bubalis]","gi|75832060|ref|NM_174131.3|",1057,0,"Bos taurus outer dense fiber of sperm tails 1 (ODF1), mRNA","Q29438",388,{"v":2e-133,"d":"2.00E-133"},"Outer dense fiber protein 1",".",".",".",".","pfam00011","HSP20","Hsp20/alpha crystallin family.","GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0007283|spermatogenesis;","GO:0001520|outer dense fiber;",".",".","."]
["HIST1H2BA","gene28619",0,60,0,19.6630607523955,0,0,0,0,"Inf","Inf",{"v":1.86133909226924e-06,"d":"1.86E-06"},0.000103318804750066,"up","yes","protein_coding","chrNC_037350.1:32155953-32156540:-","gi|982964673|ref|XP_015315477.1|",868,{"v":3e-116,"d":"3.00E-116"},"PREDICTED: histone H2B type 1-A [Bos taurus]","gi|983005615|ref|XM_015469001.1|",588,0,"PREDICTED: Bos taurus histone cluster 1, H2ba (HIST1H2BA), mRNA","Q00729",217,{"v":1e-70,"d":"1.00E-70"},"Histone H2B type 1-A",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006954|inflammatory response;GO:0071674|mononuclear cell migration;GO:0006334|nucleosome assembly;GO:0006337|nucleosome disassembly;GO:0031639|plasminogen activation;GO:0051099|positive regulation of binding;GO:0035093|spermatogenesis, exchange of chromosomal proteins;","GO:0019897|extrinsic component of plasma membrane;GO:0000788|nuclear nucleosome;GO:0000786|nucleosome;","GO:0003677|DNA binding;GO:0042393|histone binding;GO:0046982|protein heterodimerization activity;","K11252","H2B; histone H2B"]
["TSSK6","gene8929",0,49,10,19.129382617204,0,0,0,0,"Inf","Inf",{"v":2.30765348735676e-06,"d":"2.31E-06"},0.000123248321883854,"up","yes","protein_coding","chrNC_037334.1:3810331-3811955:+","gi|440892284|gb|ELR45540.1|",1515,0,"Testis-specific serine/threonine-protein kinase 6, partial [Bos mutus]","gi|982984023|ref|XM_588888.7|",1625,0,"PREDICTED: Bos taurus testis-specific serine kinase 6 (TSSK6), mRNA","Q925K9",554,0,"Testis-specific serine/threonine-protein kinase 6",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0007275|multicellular organismal development;GO:0006468|protein phosphorylation;GO:0035092|sperm chromatin condensation;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;","K08811","TSSK, STK22; testis-specific serine kinase [EC:2.7.11.1]"]
["NT5C1B","gene15152",2,50,0,16.907130434002,0,0,0,0,"Inf","Inf",{"v":9.1713619530719e-06,"d":"9.17E-06"},0.000402566350589376,"up","yes","protein_coding","chrNC_037338.1:80143685-80157735:+","gi|556756659|ref|XP_005973679.1|",2769,0,"PREDICTED: cytosolic 5'-nucleotidase 1B isoform X2 [Pantholops hodgsonii]","gi|556756658|ref|XM_005973617.1|",1629,0,"PREDICTED: Pantholops hodgsonii 5'-nucleotidase, cytosolic IB (NT5C1B), transcript variant X2, mRNA","Q96P26",770,0,"Cytosolic 5'-nucleotidase 1B",".",".",".",".","pfam06189","5-nucleotidase","5'-nucleotidase. This family consists of both eukaryotic and prokaryotic 5'-nucleotidase sequences (EC:3.1.3.5).","GO:0006195|purine nucleotide catabolic process;","GO:0005829|cytosol;GO:0005634|nucleus;","GO:0008253|5'-nucleotidase activity;GO:0000287|magnesium ion binding;GO:0000166|nucleotide binding;","K01081","E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]"]
["LOC518318","gene8893",3,46,3,16.7782478548362,0,0,0,0,"Inf","Inf",{"v":9.51520098622826e-06,"d":"9.52E-06"},0.000411962437931964,"up","yes","protein_coding","chrNC_037334.1:2590530-2591231:+","gi|982929366|ref|XP_002688551.2|",1142,{"v":2e-156,"d":"2.00E-156"},"PREDICTED: histone H3.1 [Bos taurus]","gi|982983993|ref|XM_596506.6|",702,0,"PREDICTED: Bos taurus histone H3.1 (LOC518318), mRNA","Q6LED0",270,{"v":1e-90,"d":"1.00E-90"},"Histone H3.1",".",".",".",".","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006334|nucleosome assembly;","GO:0005654|nucleoplasm;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;","K11253","H3; histone H3"]
["LLCFC1","gene5748",0,49,0,16.058166281123,0,0,0,0,"Inf","Inf",{"v":1.53524845940951e-05,"d":"1.54E-05"},0.00061090897901552,"up","yes","protein_coding","chrNC_037331.1:106251295-106252641:+","gi|982922342|ref|XP_005228669.3|",540,{"v":3e-66,"d":"3.00E-66"},"PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein C7orf34 homolog [Bos taurus]","gi|965908940|ref|XM_015090800.1|",672,0,"PREDICTED: Ovis aries musimon chromosome 4 open reading frame, human C7orf34 (C4H7orf34), transcript variant X2, mRNA","Q96L11",122,{"v":4e-33,"d":"4.00E-33"},"LLLL and CFNLAS motif-containing protein 1",".",".",".",".","pfam02956","TT_ORF1","TT viral orf 1. TT virus (TTV), isolated initially from a Japanese patient with hepatitis of unknown aetiology, has since been found to infect both healthy and diseased individuals and numerous prevalence studies have raised questions about its role in unexplained hepatitis. ORF1 is a large 750 residue protein. The N-terminal half of this protein corresponds to the capsid protein.",".","GO:0005576|extracellular region;",".",".","."]
["LOC112447816","gene11399",0,47,0,15.4027309227098,0,0,0,0,"Inf","Inf",{"v":2.27192051612602e-05,"d":"2.27E-05"},0.000845112962784767,"up","yes","protein_coding","chrNC_037335.1:66775761-66785299:+","gi|296484628|tpg|DAA26743.1|",9549,0,"TPA: hypothetical protein BOS_9029 [Bos taurus]","gi|555977179|ref|XM_005900486.1|",5428,0,"PREDICTED: Bos mutus spermatogenesis-associated protein 31E1 (LOC102286021), mRNA","Q6ZUB1",404,{"v":2e-114,"d":"2.00E-114"},"Spermatogenesis-associated protein 31E1",".",".",".",".","pfam14650","FAM75","FAM75 family.","GO:0030154|cell differentiation;GO:0007283|spermatogenesis;","GO:0016021|integral component of membrane;",".",".","."]
["RNF17","gene16033",0,45,0,14.7472955642966,0,0,0,0,"Inf","Inf",{"v":3.37191327560205e-05,"d":"3.37E-05"},0.00116610978989336,"up","yes","protein_coding","chrNC_037339.1:36524149-36634812:-","gi|528912714|ref|XP_606484.6|",8411,0,"PREDICTED: RING finger protein 17 [Bos taurus]","gi|741887213|ref|XM_606484.7|",5028,0,"PREDICTED: Bos taurus ring finger protein 17 (RNF17), mRNA","Q9BXT8",2504,0,"RING finger protein 17",".",".",".",".","pfam00567","TUDOR","Tudor domain.","GO:0007275|multicellular organismal development;GO:0007286|spermatid development;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;GO:0042803|protein homodimerization activity;","K18405","TDRD1_4_6_7; tudor domain-containing protein 1/4/6/7"]
["PRSS37","gene5665",0,45,0,14.7472955642966,0,0,0,0,"Inf","Inf",{"v":3.37191327560205e-05,"d":"3.37E-05"},0.00116610978989336,"up","yes","protein_coding","chrNC_037331.1:105071255-105077184:-","gi|965933331|ref|XP_014950897.1|",1349,0,"PREDICTED: probable inactive serine protease 37 isoform X2 [Ovis aries]","gi|402766046|ref|NM_001040569.2|",925,0,"Bos taurus protease, serine 37 (PRSS37), mRNA","Q32KU2",494,{"v":4e-176,"d":"4.00E-176"},"Probable inactive serine protease 37",".",".",".",".","pfam00089","Trypsin","Trypsin.","GO:0007339|binding of sperm to zona pellucida;GO:0016477|cell migration;GO:2000344|positive regulation of acrosome reaction;GO:0051604|protein maturation;GO:0070613|regulation of protein processing;","GO:0001669|acrosomal vesicle;GO:0005576|extracellular region;","GO:0004252|serine-type endopeptidase activity;",".","."]
["SCG2","gene2320",0,0,44,13.5133518787565,0,0,0,0,"Inf","Inf",{"v":7.06005609172091e-05,"d":"7.06E-05"},0.00217500715007672,"up","yes","protein_coding","chrNC_037329.1:111768888-111774396:-","gi|741917812|ref|XP_010800694.1|",3359,0,"PREDICTED: secretogranin-2 isoform X1 [Bos taurus]","gi|982914843|ref|XM_010802392.2|",2448,0,"PREDICTED: Bos taurus secretogranin II (SCG2), transcript variant X1, mRNA","P20616",1244,0,"Secretogranin-2",".",".",".",".","pfam01271","Granin","Granin (chromogranin or secretogranin).","GO:0001525|angiogenesis;GO:0048245|eosinophil chemotaxis;GO:0050930|induction of positive chemotaxis;GO:0035556|intracellular signal transduction;GO:0000165|MAPK cascade;GO:2000352|negative regulation of endothelial cell apoptotic process;GO:2001237|negative regulation of extrinsic apoptotic signaling pathway;GO:0050918|positive chemotaxis;GO:0001938|positive regulation of endothelial cell proliferation;","GO:0005615|extracellular space;","GO:0042056|chemoattractant activity;GO:0005125|cytokine activity;",".","."]
["ARMC3","gene16542",0,40,0,13.1087071682637,0,0,0,0,"Inf","Inf",{"v":9.14702471430466e-05,"d":"9.15E-05"},0.00271282497010214,"up","yes","protein_coding","chrNC_037340.1:23964717-24057072:+","gi|528972559|ref|XP_005214253.1|",3905,0,"PREDICTED: armadillo repeat-containing protein 3 isoform X1 [Bos taurus]","gi|741946897|ref|XM_005214196.2|",3641,0,"PREDICTED: Bos taurus armadillo repeat containing 3 (ARMC3), transcript variant X1, mRNA","Q5W041",1302,0,"Armadillo repeat-containing protein 3",".",".",".",".","pfam14381","EDR1","Ethylene-responsive protein kinase Le-CTR1. EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signalling and cell death regulation.",".","GO:0005737|cytoplasm;GO:0070062|extracellular exosome;GO:0005634|nucleus;",".",".","."]
["SPERT","gene15767",0,35,5,13.0057269402712,0,0,0,0,"Inf","Inf",{"v":9.31598448491444e-05,"d":"9.32E-05"},0.00275434563045693,"up","yes","protein_coding","chrNC_037339.1:15768622-15782386:+","gi|528971050|ref|XP_005213736.1|",2111,0,"PREDICTED: spermatid-associated protein isoform X1 [Bos taurus]","gi|965817622|ref|XM_012124405.2|",1515,0,"PREDICTED: Ovis aries musimon spermatid associated (SPERT), transcript variant X2, mRNA","A6QQS3",817,0,"Spermatid-associated protein",".",".",".",".","pfam14645","Chibby","Chibby family. This family includes the eukaryotic chibby proteins. These proteins inhibit the wingless/Wnt pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation. Chibby is Japanese for small, and is named after the RNAi phenotype seen in Drosophila.",".","GO:0031410|cytoplasmic vesicle;",".",".","."]
["C11H2orf16","gene15030",0,39,0,12.7809894890571,0,0,0,0,"Inf","Inf",0.000111845503205902,0.0031783506493701,"up","yes","protein_coding","chrNC_037338.1:72106607-72118087:-","gi|982939465|ref|XP_002691544.4|",18255,0,"PREDICTED: uncharacterized protein C2orf16 homolog [Bos taurus]","gi|982990945|ref|XM_001787492.4|",11466,0,"PREDICTED: Bos taurus chromosome 11 open reading frame, human C2orf16 (C11H2orf16), mRNA","Q68DN1",1650,0,"Uncharacterized protein C2orf16",".",".",".",".","pfam11725","AvrE","Pathogenicity factor. This family is secreted by gram-negative Gammaproteobacteria such as Pseudomonas syringae of tomato and the fire blight plant pathogen Erwinia amylovora, amongst others. It is an essential pathogenicity factor of approximately 198 kDa. Its injection into the host-plant is dependent upon the bacterial type III or Hrp secretion system. The family is long and carries a number of predicted functional regions, including an ERMS or endoplasmic reticulum membrane retention signal at both the C- and the N-termini, a leucine-zipper motif from residues 539-560, and a nuclear localisation signal at 1358-1361. this conserved AvrE-family of effectors is among the few that are required for full virulence of many phytopathogenic pseudomonads, erwinias and pantoeas.",".","GO:0070062|extracellular exosome;GO:0005634|nucleus;",".",".","."]
["KLHL10","gene24653",0,37,0,12.1255541306439,0,0,0,0,"Inf","Inf",0.000167413481177416,0.00443498053061546,"up","yes","protein_coding","chrNC_037346.1:42024147-42037172:+","gi|655871320|ref|XP_002719434.2|",3326,0,"PREDICTED: kelch-like protein 10 [Oryctolagus cuniculus]","gi|965960420|ref|XM_004012910.3|",2141,0,"PREDICTED: Ovis aries kelch like family member 10 (KLHL10), mRNA","Q6JEL3",1247,0,"Kelch-like protein 10",".",".",".",".","pfam07707","BACK","BTB And C-terminal Kelch. This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).","GO:0000902|cell morphogenesis;GO:0009566|fertilization;GO:0048873|homeostasis of number of cells within a tissue;GO:0048808|male genitalia morphogenesis;GO:0008584|male gonad development;GO:0016567|protein ubiquitination;GO:0007286|spermatid development;","GO:0031463|Cul3-RING ubiquitin ligase complex;GO:0005737|cytoplasm;",".","K10448","KLHL10; kelch-like protein 10"]
["CABS1","gene8463",0,36,1,12.1049580850454,0,0,0,0,"Inf","Inf",0.000168603366853945,0.00446235868247672,"up","yes","protein_coding","chrNC_037333.1:85734578-85736673:+","gi|942057871|ref|XP_005897105.2|",1911,0,"PREDICTED: calcium-binding and spermatid-specific protein 1 [Bos mutus]","gi|94966870|ref|NM_001040539.1|",1461,0,"Bos taurus calcium-binding protein, spermatid-specific 1 (CABS1), mRNA","Q2TBJ9",734,0,"Calcium-binding and spermatid-specific protein 1",".",".",".",".","pfam15367","CABS1","Calcium-binding and spermatid-specific protein 1. CABS1 is a family of proteins found in eukaryotes. It is also known as NYD-SP26. It binds calcium and is specifically expressed in the elongate spermatids and then localized into the principal piece of flagella of matured spermatozoa.","GO:0007283|spermatogenesis;","GO:0005743|mitochondrial inner membrane;GO:0031514|motile cilium;","GO:0005509|calcium ion binding;",".","."]
["2020-03-10","gene24848",1,34,2,12.0172675970765,0,0,0,0,"Inf","Inf",0.000174841457043217,0.00457651523935783,"up","yes","protein_coding","chrNC_037346.1:47110510-47211485:-","gi|982958143|ref|XP_015314371.1|",3615,0,"PREDICTED: probable E3 ubiquitin-protein ligase MARCH10 isoform X4 [Bos taurus]","gi|965904691|ref|XR_001433211.1|",4297,0,"PREDICTED: Ovis aries musimon membrane associated ring-CH-type finger 10 (MARCH10), transcript variant X6, misc_RNA","Q8NA82",864,0,"Probable E3 ubiquitin-protein ligase MARCH10","SPBC14F5.07",56.2,{"v":1e-06,"d":"1.00E-06"},"COG5183","pfam12906","RINGv","RING-variant domain.","GO:0016567|protein ubiquitination;",".","GO:0016740|transferase activity;GO:0008270|zinc ion binding;","K10665","MARCH10; E3 ubiquitin-protein ligase MARCH10 [EC:2.3.2.27]"]
["MUC16","gene9316",4,33,0,11.8571763611624,0,0,0,0,"Inf","Inf",0.000190446621961305,0.00486013646795884,"up","yes","protein_coding","chrNC_037334.1:13194439-13313467:-","gi|741931907|ref|XP_010805044.1|",15874,0,"PREDICTED: mucin-16 isoform X1 [Bos taurus]","gi|982984515|ref|XM_002704770.5|",11721,0,"PREDICTED: Bos taurus mucin 16, cell surface associated (MUC16), transcript variant X9, mRNA","Q8WXI7",1953,0,"Mucin-16",".",".",".",".","pfam01390","SEA","SEA domain. Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.","GO:0007155|cell adhesion;GO:0016266|O-glycan processing;GO:0002223|stimulatory C-type lectin receptor signaling pathway;","GO:0070062|extracellular exosome;GO:0019898|extrinsic component of membrane;GO:0005796|Golgi lumen;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;GO:0031982|vesicle;",".",".","."]
["LOC526966","gene34175",0,9,28,11.5488648538862,0,0,0,0,"Inf","Inf",0.000194446809994472,0.00495335887138595,"up","yes","protein_coding","chrNC_037357.1:113494123-113498088:-","gi|982974482|ref|XP_015317236.1|",1307,{"v":1e-172,"d":"1.00E-172"},"PREDICTED: melanoma-associated antigen B2 [Bos taurus]","gi|983011568|ref|XM_015470536.1|",1587,0,"PREDICTED: Bos taurus melanoma-associated antigen B2 (LOC526966), mRNA",".",".",".",".",".",".",".",".","pfam01454","MAGE","MAGE family. The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumors but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.",".",".",".",".","."]
["LOC112445119","gene34345",1,19,16,11.4012052794911,0,0,0,0,"Inf","Inf",0.000214879172306411,0.00533240697670016,"up","yes","protein_coding","chrNC_037357.1:130157656-130168476:+","gi|296470438|tpg|DAA12553.1|",2031,0,"TPA: TFIIS central domain-containing protein 1-like [Bos taurus]","gi|982974662|ref|XM_015461784.1|",1031,0,"PREDICTED: Bos taurus transcription elongation factor A (SII) N-terminal and central domain containing (TCEANC), transcript variant X1, mRNA","Q8N8B7",478,{"v":7e-165,"d":"7.00E-165"},"Transcription elongation factor A N-terminal and central domain-containing protein","ECU04g0180",64.3,{"v":1e-10,"d":"1.00E-10"},"COG1594","pfam07500","TFIIS_M","Transcription factor S-II (TFIIS), central domain. Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and pfam01096 are required for transcription activity.","GO:0006351|transcription, DNA-templated;","GO:0005634|nucleus;",".",".","."]
["LOC107132310","gene3837",0,16,20,11.3859155394675,0,0,0,0,"Inf","Inf",0.0002165082915742,0.00535750049167692,"up","yes","pseudogene","chrNC_037330.1:45491147-45517746:-","gi|589931806|ref|XP_006978705.1|",236,{"v":3e-39,"d":"3.00E-39"},"PREDICTED: 40S ribosomal protein S20-like [Peromyscus maniculatus bairdii]","gi|850474981|gb|CP011886.1|",363,0,"Ovis canadensis canadensis isolate 43U chromosome 1 sequence","Q5R924",90.9,{"v":3e-35,"d":"3.00E-35"},"40S ribosomal protein S20","SPCC576.09",71.6,{"v":4e-24,"d":"4.00E-24"},"COG0051","pfam00338","Ribosomal_S10","Ribosomal protein S10p/S20e. This family includes small ribosomal subunit S10 from prokaryotes and S20 from eukaryotes.","GO:0006412|translation;","GO:0015935|small ribosomal subunit;","GO:0003723|RNA binding;GO:0003735|structural constituent of ribosome;",".","."]
["LOC112447767","gene10823",0,35,0,11.4701187722307,0,0,0,0,"Inf","Inf",0.000250883749010672,0.00603029843557159,"up","yes","protein_coding","chrNC_037335.1:7285081-7289573:+","gi|296484965|tpg|DAA27080.1|",3265,0,"TPA: ADAM metallopeptidase domain 21 preproprotein-like [Bos taurus]","gi|965920941|ref|XM_012129126.2|",1755,0,"PREDICTED: Ovis aries disintegrin and metalloproteinase domain-containing protein 20-like (LOC101111693), transcript variant X4, mRNA","O43506",701,0,"Disintegrin and metalloproteinase domain-containing protein 20",".",".",".",".","pfam01562","Pep_M12B_propep","Reprolysin family propeptide. This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the \"cysteine switch\" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.","GO:0007339|binding of sperm to zona pellucida;GO:0007338|single fertilization;","GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0046872|metal ion binding;GO:0004222|metalloendopeptidase activity;GO:0008237|metallopeptidase activity;","K08609","ADAM20; disintegrin and metalloproteinase domain-containing protein 20 [EC:3.4.24.-]"]
["TESMIN","gene32746",0,34,0,11.1424010930241,0,0,0,0,"Inf","Inf",0.000307236218583861,0.00715571963462543,"up","yes","protein_coding","chrNC_037356.1:46118488-46159248:-","gi|803191549|ref|XP_011957594.1|",2673,0,"PREDICTED: tesmin isoform X1 [Ovis aries]","gi|803225232|ref|XM_012117540.1|",2146,0,"PREDICTED: Ovis aries musimon metallothionein-like 5, testis-specific (tesmin) (MTL5), transcript variant X3, mRNA","Q9Y4I5",785,0,"Tesmin",".",".",".",".","pfam03638","TCR","Tesmin/TSO1-like CXC domain, cysteine-rich domain. This family includes proteins that have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C. The family includes Tesmin and TSO1. This family is called a CXC domain in.","GO:0030154|cell differentiation;GO:0006875|cellular metal ion homeostasis;GO:0007275|multicellular organismal development;GO:0010038|response to metal ion;GO:0007283|spermatogenesis;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0046872|metal ion binding;",".","."]
["FAM135B","gene17685",0,33,0,10.8146834138175,0,0,0,0,"Inf","Inf",0.00037638262285238,0.00840921896053349,"up","yes","protein_coding","chrNC_037341.1:4387975-4651873:+","gi|528975232|ref|XP_005215298.1|",7127,0,"PREDICTED: protein FAM135B isoform X1 [Bos taurus]","gi|594058628|ref|XM_006053410.1|",7275,0,"PREDICTED: Bubalus bubalis family with sequence similarity 135, member B (FAM135B), transcript variant X1, mRNA","Q49AJ0",2160,0,"Protein FAM135B",".",".",".",".","pfam05057","DUF676","Putative serine esterase (DUF676). This family of proteins are probably serine esterase type enzymes with an alpha/beta hydrolase fold.","GO:0044255|cellular lipid metabolic process;",".","GO:0052689|carboxylic ester hydrolase activity;",".","."]
["TRH","gene27539",2,17,14,10.3921498906979,0,0,0,0,"Inf","Inf",0.000407735347806986,0.00898908700547477,"up","yes","protein_coding","chrNC_037349.1:55886890-55889851:-","gi|116014872|gb|ABJ52714.1|",831,{"v":6e-105,"d":"6.00E-105"},"thyrotropin releasing hormone [Bos taurus]","gi|198282114|ref|NM_001101221.1|",1129,0,"Bos taurus thyrotropin-releasing hormone (TRH), mRNA","P20396",202,{"v":7e-61,"d":"7.00E-61"},"Pro-thyrotropin-releasing hormone",".",".",".",".","pfam05438","TRH","Thyrotropin-releasing hormone (TRH). This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localized on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.","GO:0007628|adult walking behavior;GO:0007267|cell-cell signaling;GO:0042755|eating behavior;GO:0007186|G-protein coupled receptor signaling pathway;GO:0001692|histamine metabolic process;GO:0009755|hormone-mediated signaling pathway;GO:2000252|negative regulation of feeding behavior;GO:0014050|negative regulation of glutamate secretion;GO:0014054|positive regulation of gamma-aminobutyric acid secretion;GO:0032024|positive regulation of insulin secretion;GO:0009409|response to cold;GO:0051412|response to corticosterone;GO:0045471|response to ethanol;GO:0009749|response to glucose;GO:0001666|response to hypoxia;GO:0007165|signal transduction;","GO:0005576|extracellular region;GO:0005634|nucleus;GO:0005886|plasma membrane;GO:0030141|secretory granule;","GO:0008437|thyrotropin-releasing hormone activity;","K05253","TRH; thyrotropin-releasing hormone"]
["FAM170A","gene9809",0,32,0,10.4869657346109,0,0,0,0,"Inf","Inf",0.000461290363816588,0.00994047957283167,"up","yes","protein_coding","chrNC_037334.1:32734451-32787206:-","gi|296485591|tpg|DAA27706.1|",1557,0,"TPA: hypothetical protein BOS_7852 [Bos taurus]","gi|982985055|ref|XM_015464204.1|",1327,0,"PREDICTED: Bos taurus family with sequence similarity 170, member A (FAM170A), mRNA","Q66LM6",153,{"v":5e-40,"d":"5.00E-40"},"Protein FAM170A",".",".",".",".","pfam12756","zf-C2H2_2","C2H2 type zinc-finger (2 copies). This family contains two copies of a C2H2-like zinc finger domain.","GO:0045893|positive regulation of transcription, DNA-templated;GO:0006366|transcription from RNA polymerase II promoter;","GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0046872|metal ion binding;",".","."]
["MS4A14","gene19822",0,30,0,9.83153037619775,0,0,0,0,"Inf","Inf",0.000693990117304085,0.0137447642062416,"up","yes","protein_coding","chrNC_037342.1:83214109-83241884:+","gi|115497374|ref|NP_001070009.1|",4330,0,"membrane-spanning 4-domains subfamily A member 14 [Bos taurus]","gi|115497373|ref|NM_001076541.1|",3003,0,"Bos taurus membrane spanning 4-domains A14 (MS4A14), mRNA","Q96JA4",431,{"v":6e-136,"d":"6.00E-136"},"Membrane-spanning 4-domains subfamily A member 14",".",".",".",".","pfam04103","CD20","CD20-like family. This family includes the CD20 protein and the beta subunit of the high affinity receptor for IgE Fc. The high affinity receptor for IgE is a tetrameric structure consisting of a single IgE-binding alpha subunit, a single beta subunit, and two disulfide-linked gamma subunits. The alpha subunit of Fc epsilon RI and most Fc receptors are homologous members of the Ig superfamily. By contrast, the beta and gamma subunits from Fc epsilon RI are not homologous to the Ig superfamily. Both molecules have four putative transmembrane segments and a probably topology where both amino- and carboxy termini protrude into the cytoplasm. This family also includes LR8 like proteins from humans, mice and rats. The function of the human LR8 protein is unknown although it is known to be strongly expressed in the lung fibroblasts. This family also includes sarcospan is a transmembrane component of dystrophin-associated glycoprotein. Loss of the sarcoglycan complex and sarcospan alone is sufficient to cause muscular dystrophy. The role of the sarcoglycan complex and sarcospan is thought to be to strengthen the dystrophin axis connecting the basement membrane with the cytoskeleton.",".","GO:0016021|integral component of membrane;",".",".","."]
["ROPN1","gene478",0,30,0,9.83153037619775,0,0,0,0,"Inf","Inf",0.000693990117304085,0.0137447642062416,"up","yes","protein_coding","chrNC_037328.1:68349821-68384919:-","gi|555962753|ref|XP_005893464.1|",1130,{"v":4e-153,"d":"4.00E-153"},"PREDICTED: ropporin-1A [Bos mutus]","gi|115495918|ref|NM_001075900.1|",1018,0,"Bos taurus rhophilin associated tail protein 1 (ROPN1), mRNA","Q3T064",437,{"v":2e-153,"d":"2.00E-153"},"Ropporin-1",".",".",".",".","pfam02197","RIIa","Regulatory subunit of type II PKA R-subunit.","GO:0044782|cilium organization;GO:0030317|sperm motility;GO:0061512|protein localization to cilium;GO:0001932|regulation of protein phosphorylation;GO:0048240|sperm capacitation;","GO:0031514|motile cilium;",".",".","."]
["PLA2G5","gene2732",4,6,20,9.15123169474643,0,0,0,0,"Inf","Inf",0.000871533683996852,0.0162308926488996,"up","yes","protein_coding","chrNC_037329.1:132644532-132665181:-","gi|742228601|ref|XP_010828253.1|",661,{"v":2e-82,"d":"2.00E-82"},"PREDICTED: calcium-dependent phospholipase A2 isoform X1 [Bison bison bison]","gi|300796137|ref|NM_001193052.1|",1182,0,"Bos taurus phospholipase A2 group V (PLA2G5), mRNA","P39877",186,{"v":6e-56,"d":"6.00E-56"},"Calcium-dependent phospholipase A2",".",".",".",".","pfam00068","Phospholip_A2_1","Phospholipase A2. Phospholipase A2 releases fatty acids from the second carbon group of glycerol. Perhaps the best known members are secreted snake venoms, but also found in secreted pancreatic and membrane-associated forms. Structure is all-alpha, with two core disulfide-linked helices and a calcium-binding loop. This alignment represents the major family of PLA2s. A second minor family, defined by the honeybee venom PLA2 PDB:1POC and related sequences from Gila monsters (Heloderma), is not recognized. This minor family conserves the core helix pair but is substantially different elsewhere. The PROSITE pattern PA2_HIS, specific to the first core helix, recognizes both families.","GO:0050482|arachidonic acid secretion;GO:0019370|leukotriene biosynthetic process;GO:0016042|lipid catabolic process;GO:0006654|phosphatidic acid biosynthetic process;GO:0036151|phosphatidylcholine acyl-chain remodeling;GO:0036152|phosphatidylethanolamine acyl-chain remodeling;GO:0036148|phosphatidylglycerol acyl-chain remodeling;GO:0036149|phosphatidylinositol acyl-chain remodeling;GO:0036150|phosphatidylserine acyl-chain remodeling;GO:0006644|phospholipid metabolic process;GO:0006663|platelet activating factor biosynthetic process;GO:0070374|positive regulation of ERK1 and ERK2 cascade;GO:0010518|positive regulation of phospholipase activity;GO:0051591|response to cAMP;GO:0034097|response to cytokine;","GO:0005576|extracellular region;GO:0005794|Golgi apparatus;GO:0048471|perinuclear region of cytoplasm;GO:0005886|plasma membrane;","GO:0005509|calcium ion binding;GO:0047498|calcium-dependent phospholipase A2 activity;GO:0008201|heparin binding;GO:0004623|phospholipase A2 activity;","K01047","PLA2G, SPLA2; secretory phospholipase A2 [EC:3.1.1.4]"]
["FOXF2","gene28863",15,7,9,8.96746700946223,0,0,0,0,"Inf","Inf",0.000912458155835132,0.0168282764344746,"up","yes","protein_coding","chrNC_037350.1:51700547-51705418:-","gi|983005814|ref|XP_015324527.1|",1217,{"v":6e-156,"d":"6.00E-156"},"PREDICTED: forkhead box protein F2 isoform X2 [Bos taurus]","gi|983005813|ref|XM_015469041.1|",2021,0,"PREDICTED: Bos taurus forkhead box F2 (FOXF2), transcript variant X2, mRNA","O54743",446,{"v":2e-148,"d":"2.00E-148"},"Forkhead box protein F2","SPBC4C3.05",85.9,{"v":2e-16,"d":"2.00E-16"},"COG5025","pfam00250","Fork_head","Fork head domain.","GO:0030154|cell differentiation;GO:0048596|embryonic camera-type eye morphogenesis;GO:0048566|embryonic digestive tract development;GO:0042249|establishment of planar polarity of embryonic epithelium;GO:0030198|extracellular matrix organization;GO:0048806|genitalia development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0060021|palate development;","GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0000977|RNA polymerase II regulatory region sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;GO:0003705|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding;GO:0008134|transcription factor binding;GO:0001228|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding;","K09399","FOXF; forkhead box protein F"]
["LOC782251","gene11242",3,26,0,9.30252936988002,0,0,0,0,"Inf","Inf",0.00093928110864225,0.0172006606615353,"up","yes","protein_coding","chrNC_037335.1:57833482-57839539:+","gi|440896267|gb|ELR48246.1|",6463,0,"Protein FAM75D1 [Bos mutus]","gi|982986428|ref|XM_015464552.1|",4111,0,"PREDICTED: Bos taurus putative spermatogenesis-associated protein 31D3 (LOC782251), mRNA","Q6ZQQ2",712,0,"Spermatogenesis-associated protein 31D1",".",".",".",".","pfam14650","FAM75","FAM75 family.","GO:0030154|cell differentiation;GO:0007283|spermatogenesis;","GO:0016021|integral component of membrane;",".",".","."]
["LOC107131271","gene34865",34,1,0,9.18890773163778,0,0,0,0,"Inf","Inf",0.000956351837239594,0.0174349356346855,"up","yes","protein_coding","chrNW_020191578.1:41917-223794:+","gi|741907692|ref|XP_010797560.1|",4950,0,"PREDICTED: multidrug resistance-associated protein 4-like isoform X1 [Bos taurus]","gi|982992230|ref|XM_010799258.2|",2720,0,"PREDICTED: Bos taurus multidrug resistance-associated protein 4-like (LOC509854), transcript variant X1, mRNA","O15439",1735,0,"Multidrug resistance-associated protein 4","YDR135c",643,0,"COG1132","pfam00664","ABC_membrane","ABC transporter transmembrane region. This family represents a unit of six transmembrane helices. Many members of the ABC transporter family (pfam00005) have two such regions.","GO:0060271|cilium morphogenesis;GO:0002576|platelet degranulation;GO:0032310|prostaglandin secretion;GO:0055085|transmembrane transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;GO:0016020|membrane;GO:0005886|plasma membrane;GO:0031088|platelet dense granule membrane;","GO:0016404|15-hydroxyprostaglandin dehydrogenase (NAD+) activity;GO:0005524|ATP binding;GO:0015662|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism;GO:0042626|ATPase activity, coupled to transmembrane movement of substances;GO:0043225|anion transmembrane-transporting ATPase activity;","K05673","ABCC4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4"]
["FSCN3","gene5489",0,28,0,9.17609501778457,0,0,0,0,"Inf","Inf",0.00104682693358169,0.0187168424671039,"up","yes","protein_coding","chrNC_037331.1:91824112-91832363:+","gi|803253891|ref|XP_011986907.1|",3010,0,"PREDICTED: fascin-3 isoform X1 [Ovis aries musimon]","gi|982980979|ref|XM_015463123.1|",1758,0,"PREDICTED: Bos taurus fascin actin-bundling protein 3 (FSCN3), mRNA","Q9QXW4",756,0,"Fascin-3",".",".",".",".","pfam06268","Fascin","Fascin domain. This family consists of several eukaryotic fascin or singed proteins. The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture.  Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerization and binding to microfilaments only at pH values below seven. Members of this family are histidine rich, typically contain the repeated motif of HHXH.","GO:0030036|actin cytoskeleton organization;GO:0051017|actin filament bundle assembly;GO:0009653|anatomical structure morphogenesis;GO:0016477|cell migration;GO:0007163|establishment or maintenance of cell polarity;GO:0007286|spermatid development;","GO:0015629|actin cytoskeleton;GO:0031253|cell projection membrane;GO:0005737|cytoplasm;GO:0031941|filamentous actin;GO:0030175|filopodium;GO:0030426|growth cone;GO:0030027|lamellipodium;GO:0005902|microvillus;GO:0001726|ruffle;","GO:0003779|actin binding;GO:0051015|actin filament binding;GO:0030674|protein binding, bridging;","K17456","FSCN3; fascin 3"]
["ACE3","gene24858",0,24,4,9.09371083539061,0,0,0,0,"Inf","Inf",0.00106022402226364,0.0188939735035627,"up","yes","protein_coding","chrNC_037346.1:47827666-47840921:+","gi|594039216|ref|XP_006044202.1|",3576,0,"PREDICTED: angiotensin-converting enzyme-like [Bubalus bubalis]","gi|965911236|ref|XM_012171405.2|",2245,0,"PREDICTED: Ovis aries musimon angiotensin-converting enzyme-like (LOC105613829), transcript variant X3, mRNA","D0G895",977,0,"Angiotensin-converting enzyme-like protein Ace3",".",".",".",".","pfam01401","Peptidase_M2","Angiotensin-converting enzyme. Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes.",".","GO:0002080|acrosomal membrane;GO:0001669|acrosomal vesicle;GO:0016021|integral component of membrane;","GO:0008237|metallopeptidase activity;GO:0008241|peptidyl-dipeptidase activity;","K01283","ACE; peptidyl-dipeptidase A [EC:3.4.15.1]"]
["LOC101903891","gene30222",14,5,11,8.66565168142904,0,0,0,0,"Inf","Inf",0.00111255434037636,0.0196173596244692,"up","yes","protein_coding","chrNC_037352.1:36267294-36283641:+","gi|741902490|ref|XP_010798716.1|",2775,0,"PREDICTED: NXPE family member 3-like [Bos taurus]","gi|983007288|ref|XM_010800414.2|",1955,0,"PREDICTED: Bos taurus NXPE family member 3-like (LOC101903891), mRNA","Q08BN9",291,{"v":9e-87,"d":"9.00E-87"},"NXPE family member 3",".",".",".",".","pfam06312","Neurexophilin","Neurexophilin. This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.",".","GO:0005576|extracellular region;",".",".","."]
["H3F3C","gene20174",0,27,0,8.84837733857797,0,0,0,0,"Inf","Inf",0.00128721883969803,0.0220839691614097,"up","yes","protein_coding","chrNC_037343.1:30668107-30671732:+","gi|115496015|ref|NP_001069659.1|",716,{"v":1e-93,"d":"1.00E-93"},"histone H3.3C-like [Bos taurus]","gi|402743743|ref|NM_001076191.2|",618,0,"Bos taurus histone H3-like (H3F3C), mRNA","Q3SZB8",280,{"v":5e-95,"d":"5.00E-95"},"Histone H3.3C-like","YNL031c",168,{"v":6e-52,"d":"6.00E-52"},"COG2036","pfam00125","Histone","Core histone H2A/H2B/H3/H4.","GO:0006334|nucleosome assembly;","GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0031492|nucleosomal DNA binding;GO:0046982|protein heterodimerization activity;","K11253","H3; histone H3"]
["C5H12orf54","gene6379",0,27,0,8.84837733857797,0,0,0,0,"Inf","Inf",0.00128721883969803,0.0220839691614097,"up","yes","protein_coding","chrNC_037332.1:31543719-31568121:-","gi|116004203|ref|NP_001070460.1|",747,{"v":1e-97,"d":"1.00E-97"},"uncharacterized protein C12orf54 homolog [Bos taurus]","gi|116004202|ref|NM_001076992.1|",742,0,"Bos taurus chromosome 5 open reading frame, human C12orf54 (C5H12orf54), mRNA",".",".",".",".",".",".",".",".","pfam03846","SulA","Cell division inhibitor SulA.",".",".",".",".","."]
["HOXA11","gene5276",21,8,0,8.09482940721317,0,0,0,0,"Inf","Inf",0.00155813254548703,0.025681732903114,"up","yes","protein_coding","chrNC_037331.1:68857317-68861039:+","gi|741876263|ref|XP_010825652.1|",1359,{"v":1e-179,"d":"1.00E-179"},"PREDICTED: homeobox protein Hox-A11 isoform X1 [Bos taurus]","gi|982980686|ref|XM_010827350.2|",2289,0,"PREDICTED: Bos taurus homeobox A11 (HOXA11), transcript variant X1, mRNA","P31270",507,{"v":5e-173,"d":"5.00E-173"},"Homeobox protein Hox-A11",".",".",".",".","pfam12045","DUF3528","Protein of unknown function (DUF3528). This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.","GO:0009653|anatomical structure morphogenesis;GO:0009952|anterior/posterior pattern specification;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0060351|cartilage development involved in endochondral bone morphogenesis;GO:0048589|developmental growth;GO:0009953|dorsal/ventral pattern formation;GO:0042733|embryonic digit morphogenesis;GO:0035115|embryonic forelimb morphogenesis;GO:0030326|embryonic limb morphogenesis;GO:0060272|embryonic skeletal joint morphogenesis;GO:0008584|male gonad development;GO:0007501|mesodermal cell fate specification;GO:0001656|metanephros development;GO:0007275|multicellular organismal development;GO:0001759|organ induction;GO:0010720|positive regulation of cell development;GO:0032332|positive regulation of chondrocyte differentiation;GO:0045893|positive regulation of transcription, DNA-templated;GO:0009954|proximal/distal pattern formation;GO:0007338|single fertilization;GO:0001501|skeletal system development;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;GO:0060065|uterus development;","GO:0005654|nucleoplasm;GO:0032991|macromolecular complex;GO:0032993|protein-DNA complex;GO:0005667|transcription factor complex;","GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043565|sequence-specific DNA binding;",".","."]
["ACTL7A","gene11753",0,26,0,8.52065965937138,0,0,0,0,"Inf","Inf",0.00158424756113207,0.0259771075670454,"up","yes","protein_coding","chrNC_037335.1:98466288-98467808:+","gi|84370183|ref|NP_001033659.1|",2294,0,"actin-like protein 7A [Bos taurus]","gi|84370182|ref|NM_001038570.1|",1518,0,"Bos taurus actin like 7A (ACTL7A), mRNA","Q32KZ2",888,0,"Actin-like protein 7A","SPBC32H8.12c",320,{"v":2e-103,"d":"2.00E-103"},"COG5277","pfam00022","Actin","Actin.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;GO:0005794|Golgi apparatus;GO:0001673|male germ cell nucleus;GO:0031514|motile cilium;GO:0032991|macromolecular complex;",".",".","."]
["TBC1D21","gene13050",0,26,0,8.52065965937138,0,0,0,0,"Inf","Inf",0.00158424756113207,0.0259771075670454,"up","yes","protein_coding","chrNC_037337.1:20690530-20704230:+","gi|578826661|ref|XP_006720472.1|",1821,0,"PREDICTED: TBC1 domain family member 21 isoform X1 [Homo sapiens]","gi|942098669|ref|XM_005910274.2|",1103,0,"PREDICTED: Bos mutus TBC1 domain family, member 21 (TBC1D21), transcript variant X1, mRNA","Q8IYX1",640,0,"TBC1 domain family member 21","SPAC630.05",101,{"v":9e-22,"d":"9.00E-22"},"COG5210","pfam00566","RabGAP-TBC","Rab-GTPase-TBC domain. Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.","GO:0090630|activation of GTPase activity;GO:0030154|cell differentiation;GO:0006886|intracellular protein transport;GO:0031338|regulation of vesicle fusion;GO:0007283|spermatogenesis;","GO:0001669|acrosomal vesicle;GO:0005856|cytoskeleton;GO:0012505|endomembrane system;GO:0070062|extracellular exosome;GO:0005622|intracellular;","GO:0003779|actin binding;GO:0005096|GTPase activator activity;",".","."]
["UBQLN3","gene18977",0,26,0,8.52065965937138,0,0,0,0,"Inf","Inf",0.00158424756113207,0.0259771075670454,"up","yes","protein_coding","chrNC_037342.1:48059149-48061840:+","gi|942088218|ref|XP_005911734.2|",2769,0,"PREDICTED: ubiquilin-3 [Bos mutus]","gi|84370210|ref|NM_001038583.1|",2359,0,"Bos taurus ubiquilin 3 (UBQLN3), mRNA","Q9H347",841,0,"Ubiquilin-3","ECU10g1730",67,{"v":3e-11,"d":"3.00E-11"},"COG5272","pfam00240","ubiquitin","Ubiquitin family. This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.",".",".",".","K04523","UBQLN, DSK2; ubiquilin"]
["C13H20orf144","gene17170",0,25,1,8.50006361377289,0,0,0,0,"Inf","Inf",0.00159800597169451,0.0261426080151469,"up","yes","protein_coding","chrNC_037340.1:63115490-63117089:+","gi|594105757|ref|XP_006075821.1|",533,{"v":5e-65,"d":"5.00E-65"},"PREDICTED: uncharacterized protein C20orf144 homolog [Bubalus bubalis]","gi|982993619|ref|XM_005192468.3|",691,0,"PREDICTED: Bos taurus chromosome 13 open reading frame, human C20orf144 (C13H20orf144), mRNA",".",".",".",".",".",".",".",".","pfam15318","Bclt","Putative Bcl-2 like protein of testis. This family of proteins is found in eukaryotes. The family may represent a set of Bcl-2-like proteins involved in apoptosis, see UniProt:Q9BQM9.",".",".",".",".","."]
["MEIOC","gene24783",2,24,0,8.38647077463062,0,0,0,0,"Inf","Inf",0.00169675538528435,0.0273384522954315,"up","yes","protein_coding","chrNC_037346.1:44410581-44425749:+","gi|528921478|ref|XP_005195826.1|",4992,0,"PREDICTED: uncharacterized protein C17orf104 homolog isoform X1 [Bos taurus]","gi|983002277|ref|XM_005195769.3|",4561,0,"PREDICTED: Bos taurus meiosis specific with coiled-coil domain (MEIOC), transcript variant X1, mRNA","A2AG06",1767,0,"Meiosis-specific coiled-coil domain-containing protein MEIOC",".",".",".",".","pfam15189","DUF4582","Domain of unknown function (DUF4582). This family of proteins is found in eukaryotes. Proteins in this family are typically between 126 and 788 amino acids in length. In humans, it is encoded for on the chromosomal position, C17orf104.","GO:0070192|chromosome organization involved in meiosis;GO:0006302|double-strand break repair;GO:0007144|female meiosis I;GO:0051729|germline cell cycle switching, mitotic to meiotic cell cycle;GO:0007141|male meiosis I;GO:0051310|metaphase plate congression;GO:0048255|mRNA stabilization;GO:0048599|oocyte development;GO:0007286|spermatid development;GO:0007283|spermatogenesis;GO:0007130|synaptonemal complex assembly;","GO:0005737|cytoplasm;GO:0005634|nucleus;",".",".","."]
["ACTL9","gene9523",0,25,0,8.19294198016479,0,0,0,0,"Inf","Inf",0.00195165313495599,0.0302458531197335,"up","yes","protein_coding","chrNC_037334.1:17250900-17252340:-","gi|84370177|ref|NP_001033658.1|",2136,0,"actin-like protein 9 [Bos taurus]","gi|402744029|ref|NM_001038569.2|",1441,0,"Bos taurus actin like 9 (ACTL9), mRNA","Q2T9W4",827,0,"Actin-like protein 9","SPBC32H8.12c",309,{"v":2e-99,"d":"2.00E-99"},"COG5277","pfam00022","Actin","Actin.",".","GO:0005737|cytoplasm;GO:0005856|cytoskeleton;",".",".","."]
["TSSK1B","gene21767",1,23,1,8.10525149219592,0,0,0,0,"Inf","Inf",0.00203300553152298,0.0311847746343452,"up","yes","protein_coding","chrNC_037344.1:72591117-72592556:+","gi|296478282|tpg|DAA20397.1|",1843,0,"TPA: testis-specific serine kinase 1 [Bos taurus]","gi|402692913|ref|NM_001083710.2|",1431,0,"Bos taurus testis-specific serine kinase 1B (TSSK1B), mRNA","Q3SZW1",714,0,"Testis-specific serine/threonine-protein kinase 1",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0007275|multicellular organismal development;GO:0006468|protein phosphorylation;GO:0007286|spermatid development;","GO:0001669|acrosomal vesicle;GO:0005737|cytoplasm;GO:0031514|motile cilium;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0046872|metal ion binding;GO:0004674|protein serine/threonine kinase activity;","K08811","TSSK, STK22; testis-specific serine kinase [EC:2.7.11.1]"]
["HMGB4","gene4599",2,23,0,8.05875309542403,0,0,0,0,"Inf","Inf",0.00209006001882,0.0317526636831489,"up","yes","protein_coding","chrNC_037330.1:111927002-111927609:-","gi|742125006|ref|XP_010839519.1|",1039,{"v":7e-142,"d":"7.00E-142"},"PREDICTED: high mobility group protein B4 [Bison bison bison]","gi|746816095|ref|NM_001040562.3|",608,0,"Bos taurus high mobility group box 4 (HMGB4), mRNA","Q32L34",404,{"v":2e-143,"d":"2.00E-143"},"High mobility group protein B4","YBR089c-a",62.4,{"v":5e-12,"d":"5.00E-12"},"COG5648","pfam00505","HMG_box","HMG (high mobility group) box.",".","GO:0005694|chromosome;GO:0005634|nucleus;","GO:0003677|DNA binding;","K11297","HMGB4; high mobility group protein B4"]
["FAM71E2","gene23313",0,24,0,7.8652243009582,0,0,0,0,"Inf","Inf",0.00240574017807166,0.035199063087468,"up","yes","protein_coding","chrNC_037345.1:62117538-62124492:+","gi|296477230|tpg|DAA19345.1|",4009,0,"TPA: hypothetical protein BOS_18080 [Bos taurus]","gi|965904313|ref|XM_015090081.1|",2548,0,"PREDICTED: Ovis aries musimon family with sequence similarity 71 member E2 (FAM71E2), transcript variant X2, mRNA","Q8N5Q1",668,0,"Protein FAM71E2",".",".",".",".","pfam12480","DUF3699","Protein of unknown function (DUF3699). This domain family is found in eukaryotes, and is approximately 80 amino acids in length.",".","GO:0005634|nucleus;",".",".","."]
["PRM2","gene29721",0,23,1,7.84462825535971,0,0,0,0,"Inf","Inf",0.00242792992709014,0.0353156320110753,"up","yes","protein_coding","chrNC_037352.1:9933488-9934665:-","gi|742167257|ref|XP_010848970.1|",169,{"v":3e-12,"d":"3.00E-12"},"PREDICTED: protamine-2 [Bison bison bison]","gi|402745711|ref|NM_174157.4|",537,0,"Bos taurus protamine 2 (PRM2), mRNA",".",".",".",".",".",".",".",".",".",".",".",".",".",".",".","."]
["TNP1","gene2223",0,23,0,7.53750662175161,0,0,0,0,"Inf","Inf",0.00296743973843368,0.0409876098953687,"up","yes","protein_coding","chrNC_037329.1:104859771-104860361:-","gi|965922418|ref|XP_014949014.1|",280,{"v":1e-31,"d":"1.00E-31"},"PREDICTED: spermatid nuclear transition protein 1 isoform X1 [Ovis aries]","gi|74267769|gb|BC102598.1|",371,0,"Bos taurus transition protein 1 (during histone to protamine replacement), mRNA (cDNA clone MGC:127897 IMAGE:7961570), complete cds","P17305",70.1,{"v":3e-15,"d":"3.00E-15"},"Spermatid nuclear transition protein 1",".",".",".",".","pfam02079","TP1","Nuclear transition protein 1.","GO:0006338|chromatin remodeling;GO:0006342|chromatin silencing;GO:0030317|sperm motility;GO:0007275|multicellular organismal development;GO:0045892|negative regulation of transcription, DNA-templated;GO:0006337|nucleosome disassembly;GO:0010954|positive regulation of protein processing;GO:0019953|sexual reproduction;GO:0000012|single strand break repair;GO:0007286|spermatid development;GO:0007290|spermatid nucleus elongation;GO:0035093|spermatogenesis, exchange of chromosomal proteins;","GO:0001673|male germ cell nucleus;GO:0000788|nuclear nucleosome;GO:0000786|nucleosome;GO:0005634|nucleus;","GO:0003677|DNA binding;",".","."]
["ZNF541","gene22896",0,23,0,7.53750662175161,0,0,0,0,"Inf","Inf",0.00296743973843368,0.0409876098953687,"up","yes","protein_coding","chrNC_037345.1:54493525-54519869:-","gi|982954057|ref|XP_015313711.1|",6617,0,"PREDICTED: zinc finger protein 541 [Bos taurus]","gi|983000238|ref|XM_015467604.1|",4628,0,"PREDICTED: Bos taurus zinc finger protein 541 (ZNF541), mRNA","Q9H0D2",1815,0,"Zinc finger protein 541",".",".",".",".","pfam01448","ELM2","ELM2 domain. The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in a member from Arabidopsis thaliana. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.","GO:0030154|cell differentiation;GO:0007275|multicellular organismal development;GO:0006357|regulation of transcription from RNA polymerase II promoter;GO:0007283|spermatogenesis;GO:0006351|transcription, DNA-templated;","GO:0000118|histone deacetylase complex;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0003700|transcription factor activity, sequence-specific DNA binding;GO:0046872|metal ion binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0008134|transcription factor binding;GO:0044212|transcription regulatory region DNA binding;",".","."]
["TSSK2","gene21768",0,22,1,7.51691057615312,0,0,0,0,"Inf","Inf",0.00299575321129835,0.0413306745026854,"up","yes","protein_coding","chrNC_037344.1:72595682-72597020:+","gi|528918616|ref|XP_005195214.1|",1903,0,"PREDICTED: testis-specific serine/threonine-protein kinase 2 [Bos taurus]","gi|982998783|ref|XM_005195157.3|",1339,0,"PREDICTED: Bos taurus testis-specific serine kinase 2 (TSSK2), mRNA","O54863",702,0,"Testis-specific serine/threonine-protein kinase 2",".",".",".",".","pfam00069","Pkinase","Protein kinase domain.","GO:0035556|intracellular signal transduction;GO:0007275|multicellular organismal development;GO:0046777|protein autophosphorylation;GO:0006468|protein phosphorylation;GO:0007286|spermatid development;","GO:0001669|acrosomal vesicle;GO:0005814|centriole;GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0005524|ATP binding;GO:0000287|magnesium ion binding;GO:0004674|protein serine/threonine kinase activity;","K08811","TSSK, STK22; testis-specific serine kinase [EC:2.7.11.1]"]
["RBM46","gene20924",0,22,0,7.20978894254502,0,0,0,0,"Inf","Inf",0.00366327422936877,0.0478557129295423,"up","yes","protein_coding","chrNC_037344.1:2540688-2599474:-","gi|859897168|ref|XP_012901085.1|",2527,0,"PREDICTED: probable RNA-binding protein 46 isoform X4 [Mustela putorius furo]","gi|982949496|ref|XM_010813650.2|",2605,0,"PREDICTED: Bos taurus RNA binding motif protein 46 (RBM46), transcript variant X3, mRNA","Q4R2Z0",961,0,"Probable RNA-binding protein 46",".",".",".",".","pfam14709","DND1_DSRM","double strand RNA binding domain from DEAD END PROTEIN 1. A C-terminal domain in human dead end protein 1 (DND1_HUMAN) homologous to double strand RNA binding domains (PF00035, PF00333)",".",".","GO:0003723|RNA binding;",".","."]
["ZNRF4","gene9594",0,22,0,7.20978894254502,0,0,0,0,"Inf","Inf",0.00366327422936877,0.0478557129295423,"up","yes","protein_coding","chrNC_037334.1:18836615-18838843:+","gi|982930731|ref|XP_015327542.1|",1704,0,"PREDICTED: zinc/RING finger protein 4 [Bos taurus]","gi|942095123|ref|XM_005909008.2|",1548,0,"PREDICTED: Bos mutus zinc and ring finger 4 (ZNRF4), mRNA","Q4R6Y5",442,{"v":9e-149,"d":"9.00E-149"},"E3 ubiquitin-protein ligase ZNRF4",".",".",".",".","pfam13639","zf-RING_2","Ring finger domain.","GO:0016567|protein ubiquitination;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;","GO:0046872|metal ion binding;GO:0016740|transferase activity;","K15715","ZNRF4; Zinc/RING finger protein 4"]
["ADAM2","gene31345",0,21,1,7.18919289694653,0,0,0,0,"Inf","Inf",0.00369955770140843,0.0481704868127699,"up","yes","protein_coding","chrNC_037354.1:34592557-34693925:-","gi|56687500|ref|NP_776653.1|",3854,0,"disintegrin and metalloproteinase domain-containing protein 2 precursor [Bos taurus]","gi|942059173|ref|XM_005897530.2|",2582,0,"PREDICTED: Bos mutus ADAM metallopeptidase domain 2 (ADAM2), mRNA","O77780",1489,0,"Disintegrin and metalloproteinase domain-containing protein 2",".",".",".",".","pfam01421","Reprolysin","Reprolysin (M12B) family zinc metalloprotease. The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as human ADAM8 and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.","GO:0007155|cell adhesion;GO:0007338|single fertilization;","GO:0016021|integral component of membrane;","GO:0004222|metalloendopeptidase activity;","K06833","ADAM2; disintegrin and metalloproteinase domain-containing protein 2 [EC:3.4.24.-]"]
["SPZ1","gene25292",0,19,3,7.14800080574955,0,0,0,0,"Inf","Inf",0.00371411403739803,0.0482926059940294,"up","yes","protein_coding","chrNC_037347.1:276052-283737:+","gi|94966881|ref|NP_001035630.1|",1836,0,"spermatogenic leucine zipper protein 1 [Bos taurus]","gi|402743394|ref|NM_001040540.2|",1544,0,"Bos taurus spermatogenic leucine zipper 1 (SPZ1), mRNA","Q32L17",711,0,"Spermatogenic leucine zipper protein 1",".",".",".",".","pfam10174","Cast","RIM-binding protein of the cytomatrix active zone. This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.","GO:0006351|transcription, DNA-templated;","GO:0005737|cytoplasm;GO:0005634|nucleus;","GO:0003677|DNA binding;GO:0003700|transcription factor activity, sequence-specific DNA binding;","K17482","SPZ1; spermatogenic leucine zipper protein 1"]

{"sheet":"Shandong-specific-mRNA","index":3,"n_rows":24,"n_cols":42,"rows_kept":24,"flags":["formulas_cached_only"]}
["GeneName","Gene","L1_count","L2_count","L3_count","L_normalize","B1_count","B2_count","B3_count","B_normalize","FoldChange","Log2FoldChange","pval","padj","Up/Down","Significant","Biotype","Position","NR:Seq-id","NR:Score","NR:Evalue","NR:Description","NT:Seq-id","NT:Score","NT:Evalue","NT:Description","Uniprot:UniProtKB-AC","Uniprot:Score","Uniprot:Evalue","Uniprot:Description","COG:gene","COG:Score","COG:Eval","COG:num","Pfam:pfam_ID","Pfam:pfam_Name","Pfam:pfam_Description","GO:biological_process","GO:cellular_component","GO:molecular_function","KEGG:KO","KEGG:Description"]
["UMOD","gene29808",0,0,0,0,0,313,108,153.852181046646,"Inf","Inf",{"v":1.58141416557383e-15,"d":"1.58E-15"},{"v":6.09720642675499e-13,"d":"6.10E-13"},"down","yes","protein_coding","chrNC_037352.1:18009949-18028531:-","gi|296473384|tpg|DAA15499.1|",3246,0,"TPA: uromodulin precursor [Bos taurus]","gi|942053993|ref|XM_005895574.2|",2316,0,"PREDICTED: Bos mutus uromodulin (UMOD), transcript variant X1, mRNA","P48733",1255,0,"Uromodulin",".",".",".",".","pfam00100","Zona_pellucida","Zona pellucida-like domain.",".","GO:0031225|anchored component of membrane;GO:0016324|apical plasma membrane;GO:0016323|basolateral plasma membrane;GO:0060170|ciliary membrane;GO:0005929|cilium;GO:0005576|extracellular region;GO:0000922|spindle pole;","GO:0005509|calcium ion binding;","K18274","UMOD; uromodulin"]
["PRSS2","gene5743",0,0,0,0,135,48,105,105.976248774043,"Inf","Inf",{"v":1.87853614272432e-13,"d":"1.88E-13"},{"v":5.10442997029216e-11,"d":"5.10E-11"},"down","yes","protein_coding","chrNC_037331.1:106071891-106075636:+","gi|157279044|gb|AAI34795.1|",1285,{"v":2e-177,"d":"2.00E-177"},"PRSS2 protein [Bos taurus]","gi|157279043|gb|BC134794.1|",777,0,"Bos taurus protease, serine, 2 (trypsin 2), mRNA (cDNA clone MGC:157375 IMAGE:8631384), complete cds","Q29463",491,{"v":1e-175,"d":"1.00E-175"},"Anionic trypsin","VC1200",109,{"v":1e-26,"d":"1.00E-26"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0030574|collagen catabolic process;GO:0007586|digestion;GO:0006508|proteolysis;","GO:0005576|extracellular region;GO:0005615|extracellular space;","GO:0005509|calcium ion binding;GO:0004252|serine-type endopeptidase activity;",".","."]
["SLC12A1","gene13805",0,0,0,0,0,176,59,85.8872125608834,"Inf","Inf",{"v":1.02422387102544e-10,"d":"1.02E-10"},{"v":1.6794328312774e-08,"d":"1.68E-08"},"down","yes","protein_coding","chrNC_037337.1:62094457-62182501:-","gi|528966552|ref|XP_005211956.1|",5575,0,"PREDICTED: solute carrier family 12 member 1 isoform X1 [Bos taurus]","gi|982989706|ref|XM_015465136.1|",4670,0,"PREDICTED: Bos taurus solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1), transcript variant X2, mRNA","Q13621",1999,0,"Solute carrier family 12 member 1","SPBC18H10.16",225,{"v":4e-59,"d":"4.00E-59"},"COG0531","pfam00324","AA_permease","Amino acid permease.","GO:0034220|ion transmembrane transport;GO:0006811|ion transport;","GO:0016324|apical plasma membrane;GO:0070062|extracellular exosome;GO:0016021|integral component of membrane;GO:0016020|membrane;GO:0005886|plasma membrane;","GO:0008511|sodium:potassium:chloride symporter activity;","K14425","SLC12A1, NKCC2; solute carrier family 12 (sodium/potassium/chloride transporter), member 1"]
["SLC34A1","gene9870",0,0,0,0,7,61,18,31.5001303318086,"Inf","Inf",{"v":7.35782467262822e-06,"d":"7.36E-06"},0.000331113715669962,"down","yes","protein_coding","chrNC_037334.1:38883084-38896500:+","gi|157073970|ref|NP_001096693.1|",2776,0,"sodium-dependent phosphate transport protein 2A [Bos taurus]","gi|157073969|ref|NM_001103223.1|",2476,0,"Bos taurus solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 (SLC34A1), mRNA","O97704",1033,0,"Sodium-dependent phosphate transport protein 2A","VC0676",83.2,{"v":4e-16,"d":"4.00E-16"},"COG1283","pfam02690","Na_Pi_cotrans","Na+/Pi-cotransporter. This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule.","GO:0055062|phosphate ion homeostasis;GO:0006817|phosphate ion transport;GO:0006814|sodium ion transport;","GO:0016324|apical plasma membrane;GO:0016021|integral component of membrane;GO:0005886|plasma membrane;","GO:0015321|sodium-dependent phosphate transmembrane transporter activity;GO:0015293|symporter activity;","K14683","SLC34A, NPT, nptA; solute carrier family 34 (sodium-dependent phosphate cotransporter)"]
["RDH16","gene6658",0,0,0,0,0,52,31,30.2735131295016,"Inf","Inf",{"v":9.29444018082601e-06,"d":"9.29E-06"},0.000404237306096261,"down","yes","protein_coding","chrNC_037332.1:56530305-56538401:+","gi|115495313|ref|NP_001069264.1|",1611,0,"retinol dehydrogenase 16 [Bos taurus]","gi|982925773|ref|XM_005206607.3|",2934,0,"PREDICTED: Bos taurus retinol dehydrogenase 16 (all-trans) (RDH16), transcript variant X11, mRNA","O75452",503,{"v":3e-168,"d":"3.00E-168"},"Retinol dehydrogenase 16",".",".",".",".","pfam00106","adh_short","short chain dehydrogenase. This family contains a wide variety of dehydrogenases.","GO:0006629|lipid metabolic process;","GO:0005789|endoplasmic reticulum membrane;GO:0016021|integral component of membrane;GO:0043231|intracellular membrane-bounded organelle;GO:0031090|organelle membrane;","GO:0009055|electron carrier activity;GO:0004745|retinol dehydrogenase activity;","K11154","RDH16; retinol dehydrogenase 16 [EC:1.1.1.-]"]
["HAO2","gene3571",0,0,0,0,0,52,28,29.1905944641419,"Inf","Inf",{"v":1.28035859770916e-05,"d":"1.28E-05"},0.000527888889468786,"down","yes","protein_coding","chrNC_037330.1:23720165-23764186:-","gi|78050047|ref|NP_001030243.1|",1763,0,"hydroxyacid oxidase 2 [Bos taurus]","gi|742154973|ref|XM_010847214.1|",1244,0,"PREDICTED: Bison bison bison 3 beta-hydroxysteroid dehydrogenase/Delta 5-->gi|742154975|ref|XM_010847215.1| PREDICTED: Bison bison bison hydroxyacid oxidase 2 (long chain) (HAO2), transcript variant X1, mRNA","Q3ZBW2",681,0,"Hydroxyacid oxidase 2","all0170",257,{"v":8e-74,"d":"8.00E-74"},"COG1304","pfam01070","FMN_dh","FMN-dependent dehydrogenase.","GO:0019395|fatty acid oxidation;","GO:0005777|peroxisome;","GO:0010181|FMN binding;GO:0052853|long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity;GO:0052854|medium-chain-(S)-2-hydroxy-acid oxidase activity;GO:0005102|receptor binding;GO:0052852|very-long-chain-(S)-2-hydroxy-acid oxidase activity;","K11517","HAO; (S)-2-hydroxy-acid oxidase [EC:1.1.3.15]"]
["ACMSD","gene1920",0,0,0,0,7,26,25,21.1823756363508,"Inf","Inf",{"v":3.36443392993414e-05,"d":"3.36E-05"},0.00116610978989336,"down","yes","protein_coding","chrNC_037329.1:62363200-62424582:-","gi|115496732|ref|NP_001069162.1|",1607,0,"2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [Bos taurus]","gi|982913860|ref|XM_015475769.1|",1644,0,"PREDICTED: Bos taurus aminocarboxymuconate semialdehyde decarboxylase (ACMSD), transcript variant X3, mRNA","Q0II68",623,0,"2-amino-3-carboxymuconate-6-semialdehyde decarboxylase","slr0619",128,{"v":6e-32,"d":"6.00E-32"},"COG2159","pfam04909","Amidohydro_2","Amidohydrolase. These proteins are amidohydrolases that are related to pfam01979.","GO:0051259|protein oligomerization;","GO:0005829|cytosol;","GO:0001760|aminocarboxymuconate-semialdehyde decarboxylase activity;GO:0016831|carboxy-lyase activity;GO:0016787|hydrolase activity;GO:0008270|zinc ion binding;","K03392","ACMSD; aminocarboxymuconate-semialdehyde decarboxylase [EC:4.1.1.45]"]
["PAX2","gene30656",0,0,0,0,0,51,14,23.769986456807,"Inf","Inf",{"v":6.66760977623442e-05,"d":"6.67E-05"},0.00207000625164031,"down","yes","protein_coding","chrNC_037353.1:21589730-21679960:+","gi|982968332|ref|XP_015316206.1|",2109,0,"PREDICTED: paired box protein Pax-2 isoform X12 [Bos taurus]","gi|983007848|ref|XM_015469575.1|",5950,0,"PREDICTED: Bos taurus paired box 2 (PAX2), transcript variant X16, mRNA","Q02962",736,0,"Paired box protein Pax-2",".",".",".",".","pfam00292","PAX","'Paired box' domain.","GO:0007568|aging;GO:0007409|axonogenesis;GO:0048854|brain morphogenesis;GO:0001658|branching involved in ureteric bud morphogenesis;GO:0043010|camera-type eye development;GO:0001709|cell fate determination;GO:0071364|cellular response to epidermal growth factor stimulus;GO:0071333|cellular response to glucose stimulus;GO:0070301|cellular response to hydrogen peroxide;GO:0071300|cellular response to retinoic acid;GO:0090102|cochlea development;GO:0090103|cochlea morphogenesis;GO:0010001|glial cell differentiation;GO:0042472|inner ear morphogenesis;GO:0060231|mesenchymal to epithelial transition;GO:0003337|mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0007501|mesodermal cell fate specification;GO:0001823|mesonephros development;GO:0072205|metanephric collecting duct development;GO:0072221|metanephric distal convoluted tubule development;GO:0072207|metanephric epithelium development;GO:0072162|metanephric mesenchymal cell differentiation;GO:0072075|metanephric mesenchyme development;GO:0072289|metanephric nephron tubule formation;GO:0043066|negative regulation of apoptotic process;GO:1900215|negative regulation of apoptotic process involved in metanephric collecting duct development;GO:1900218|negative regulation of apoptotic process involved in metanephric nephron tubule development;GO:0043154|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;GO:0045918|negative regulation of cytolysis;GO:0072305|negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis;GO:1900212|negative regulation of mesenchymal cell apoptotic process involved in metanephros development;GO:0043069|negative regulation of programmed cell death;GO:2000378|negative regulation of reactive oxygen species metabolic process;GO:0045892|negative regulation of transcription, DNA-templated;GO:0072179|nephric duct formation;GO:0001843|neural tube closure;GO:0061360|optic chiasma development;GO:0002072|optic cup morphogenesis involved in camera-type eye development;GO:0021554|optic nerve development;GO:0021631|optic nerve morphogenesis;GO:0021633|optic nerve structural organization;GO:0090190|positive regulation of branching involved in ureteric bud morphogenesis;GO:0050679|positive regulation of epithelial cell proliferation;GO:0072108|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:2000594|positive regulation of metanephric DCT cell differentiation;GO:0072300|positive regulation of metanephric glomerulus development;GO:2000597|positive regulation of optic nerve formation;GO:0045944|positive regulation of transcription from RNA polymerase II promoter;GO:0045893|positive regulation of transcription, DNA-templated;GO:0039003|pronephric field specification;GO:0048793|pronephros development;GO:0043491|protein kinase B signaling;GO:0072593|reactive oxygen species metabolic process;GO:0072307|regulation of metanephric nephron tubule epithelial cell differentiation;GO:0035566|regulation of metanephros size;GO:0031667|response to nutrient levels;GO:0003406|retinal pigment epithelium development;GO:0048863|stem cell differentiation;GO:0006366|transcription from RNA polymerase II promoter;GO:0006351|transcription, DNA-templated;GO:0072189|ureter development;GO:0035799|ureter maturation;GO:0001655|urogenital system development;GO:0021650|vestibulocochlear nerve formation;GO:0007601|visual perception;","GO:0034451|centriolar satellite;GO:0005794|Golgi apparatus;GO:0005764|lysosome;GO:0005815|microtubule organizing center;GO:0005730|nucleolus;GO:0005634|nucleus;GO:0032991|macromolecular complex;GO:0032993|protein-DNA complex;","GO:0003677|DNA binding;GO:0000987|core promoter proximal region sequence-specific DNA binding;GO:0000981|RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0016175|superoxide-generating NADPH oxidase activity;GO:0008134|transcription factor binding;GO:0044212|transcription regulatory region DNA binding;","K15608","PAX2; paired box protein 2"]
["UOX","gene3998",0,0,0,0,1,47,9,20.8709398287679,"Inf","Inf",0.000157267756611582,0.00422268842172665,"down","yes","protein_coding","chrNC_037330.1:59700670-59736411:+","gi|742204047|ref|XP_010858603.1|",1717,0,"PREDICTED: uricase [Bison bison bison]","gi|402743756|ref|NM_001075648.2|",1868,0,"Bos taurus urate oxidase (UOX), mRNA","Q3MHG7",637,0,"Uricase","SPCC1223.09",156,{"v":7e-42,"d":"7.00E-42"},"COG3648","pfam01014","Uricase","Uricase.","GO:0006144|purine nucleobase metabolic process;GO:0019628|urate catabolic process;","GO:0005777|peroxisome;","GO:0004846|urate oxidase activity;","K00365","uaZ; urate oxidase [EC:1.7.3.3]"]
["TRNAG-CCC","gene25335",0,0,0,0,18,3,19,14.6872732109078,"Inf","Inf",0.000451633845088458,0.00977660488180485,"down","yes","tRNA","chrNC_037347.1:4627321-4627393:-",".",".",".",".","gi|4666291|dbj|AB010597.1|",64,{"v":3e-24,"d":"3.00E-24"},"Physeter catodon SINE DNA, clone: PM(1-III)8",".",".",".",".",".",".",".",".","pfam06003","SMN","Survival motor neuron protein (SMN). This family consists of several eukaryotic survival motor neuron (SMN) proteins. The Survival of Motor Neurons (SMN) protein, the product of the spinal muscular atrophy-determining gene, is part of a large macromolecular complex (SMN complex) that functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs). The SMN complex functions as a specificity factor essential for the efficient assembly of Sm proteins on U snRNAs and likely protects cells from illicit, and potentially deleterious, non-specific binding of Sm proteins to RNAs.",".",".",".",".","."]
["SLC22A6","gene32517",0,0,0,0,0,35,11,16.8152666876162,"Inf","Inf",0.000507000230973087,0.0106528162800675,"down","yes","protein_coding","chrNC_037356.1:41285418-41293425:-","gi|741979815|ref|XP_010819299.1|",2597,0,"PREDICTED: solute carrier family 22 member 6 isoform X1 [Bos taurus]","gi|982971676|ref|XM_010820997.2|",1995,0,"PREDICTED: Bos taurus solute carrier family 22 (organic anion transporter), member 6 (SLC22A6), transcript variant X1, mRNA","Q864Z3",877,0,"Solute carrier family 22 member 6",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0015742|alpha-ketoglutarate transport;GO:0015711|organic anion transport;GO:0097254|renal tubular secretion;GO:0043252|sodium-independent organic anion transport;GO:0015747|urate transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0005452|inorganic anion exchanger activity;GO:0008514|organic anion transmembrane transporter activity;GO:0015347|sodium-independent organic anion transmembrane transporter activity;GO:0015143|urate transmembrane transporter activity;","K08203","SLC22A6, OAT1; MFS transporter, OCT family, solute carrier family 22 (organic anion transporter), member 6"]
["SLC17A1","gene28615",0,0,0,0,0,37,9,16.8272960486886,"Inf","Inf",0.000526498820437403,0.0109566286257473,"down","yes","protein_coding","chrNC_037350.1:32027267-32267361:+","gi|982964650|ref|XP_010816831.2|",2272,0,"PREDICTED: sodium-dependent phosphate transport protein 1 [Bos taurus]","gi|983005605|ref|XR_001499304.1|",1735,0,"PREDICTED: Bos taurus solute carrier family 17 (organic anion transporter), member 1 (SLC17A1), transcript variant X5, misc_RNA","Q28722",528,{"v":2e-171,"d":"2.00E-171"},"Sodium-dependent phosphate transport protein 1",".",".",".",".","pfam07690","MFS_1","Major Facilitator Superfamily.","GO:0006814|sodium ion transport;GO:0015747|urate transport;","GO:0016324|apical plasma membrane;GO:0016021|integral component of membrane;","GO:0015114|phosphate ion transmembrane transporter activity;GO:0015293|symporter activity;","K12300","SLC17A1S; MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 1/2/3/4"]
["SLC5A12","gene19340",0,0,0,0,0,35,10,16.454293799163,"Inf","Inf",0.000578213067945952,0.0118427832315621,"down","yes","protein_coding","chrNC_037342.1:57364696-57415989:-","gi|155371849|ref|NP_001094529.1|",3188,0,"sodium-coupled monocarboxylate transporter 2 [Bos taurus]","gi|402744589|ref|NM_001101059.2|",2927,0,"Bos taurus solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 (SLC5A12), mRNA","A7MBD8",1232,0,"Sodium-coupled monocarboxylate transporter 2","sll1087",160,{"v":1e-40,"d":"1.00E-40"},"COG0591","pfam00474","SSF","Sodium:solute symporter family. Membership of this family is supported by a significant blast score.","GO:0006814|sodium ion transport;","GO:0016324|apical plasma membrane;GO:0016021|integral component of membrane;","GO:0015129|lactate transmembrane transporter activity;GO:0015293|symporter activity;","K14388","SLC5A8_12, SMCT; solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12"]
["SLC22A8","gene32518",0,0,0,0,0,25,17,15.3112283284412,"Inf","Inf",0.000641608208461288,0.0129286395742498,"down","yes","protein_coding","chrNC_037356.1:41302544-41322828:-","gi|329664560|ref|NP_001193175.1|",2599,0,"solute carrier family 22 member 8 [Bos taurus]","gi|329664559|ref|NM_001206246.1|",2145,0,"Bos taurus solute carrier family 22 (organic anion transporter), member 8 (SLC22A8), mRNA","Q70BM6",874,0,"Solute carrier family 22 member 8",".",".",".",".","pfam00083","Sugar_tr","Sugar (and other) transporter.","GO:0009636|response to toxic substance;GO:0043252|sodium-independent organic anion transport;","GO:0016323|basolateral plasma membrane;GO:0005887|integral component of plasma membrane;","GO:0005452|inorganic anion exchanger activity;GO:0015347|sodium-independent organic anion transmembrane transporter activity;","K08205","SLC22A8, OAT3; MFS transporter, OCT family, solute carrier family 22 (organic anion transporter), member 8"]
["TMEM63C","gene14148",0,0,0,0,18,8,9,12.9124821713226,"Inf","Inf",0.00094837164286694,0.0173115747553657,"down","yes","protein_coding","chrNC_037337.1:88380856-88459276:+","gi|329663882|ref|NP_001193090.1|",4063,0,"calcium permeable stress-gated cation channel 1 [Bos taurus]","gi|982937953|ref|XM_005212219.3|",5591,0,"PREDICTED: Bos taurus transmembrane protein 63C (TMEM63C), transcript variant X1, mRNA","Q9P1W3",1326,0,"Calcium permeable stress-gated cation channel 1","SPAC24H6.13",57.8,{"v":3e-07,"d":"3.00E-07"},"COG5594","pfam02714","DUF221","Domain of unknown function DUF221. This family consists of hypothetical transmembrane proteins none of which have any function, the aligned region is at 538 residues at maximum length.","GO:0006812|cation transport;","GO:0016021|integral component of membrane;","GO:0005227|calcium activated cation channel activity;",".","."]
["G6PC","gene24705",0,0,0,0,0,31,7,13.9034248578455,"Inf","Inf",0.00137152294933846,0.0232230986751191,"down","yes","protein_coding","chrNC_037346.1:42949589-42962432:+","gi|528996124|ref|XP_005220797.1|",1457,0,"PREDICTED: glucose-6-phosphatase isoform X1 [Bos taurus]","gi|982957859|ref|XM_005220740.3|",3894,0,"PREDICTED: Bos taurus glucose-6-phosphatase, catalytic subunit (G6PC), transcript variant X1, mRNA","Q29RU6",541,{"v":2e-177,"d":"2.00E-177"},"Glucose-6-phosphatase",".",".",".",".","pfam01569","PAP2","PAP2 superfamily. This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidizing halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.","GO:0042632|cholesterol homeostasis;GO:0006094|gluconeogenesis;GO:0051156|glucose 6-phosphate metabolic process;GO:0042593|glucose homeostasis;GO:0015760|glucose-6-phosphate transport;GO:0005980|glycogen catabolic process;GO:0035264|multicellular organism growth;GO:0010468|regulation of gene expression;GO:0008202|steroid metabolic process;GO:0006641|triglyceride metabolic process;GO:0046415|urate metabolic process;","GO:0030176|integral component of endoplasmic reticulum membrane;","GO:0004346|glucose-6-phosphatase activity;GO:0042301|phosphate ion binding;GO:0016773|phosphotransferase activity, alcohol group as acceptor;","K01084","G6PC; glucose-6-phosphatase [EC:3.1.3.9]"]
["DAO","gene21524",0,0,0,0,0,32,6,13.9094395383817,"Inf","Inf",0.00139127689452264,0.0235017886782862,"down","yes","protein_coding","chrNC_037344.1:64095347-64114577:-","gi|982950425|ref|XP_015330977.1|",1870,0,"PREDICTED: D-amino-acid oxidase isoform X1 [Bos taurus]","gi|594041074|ref|XM_006045027.1|",2429,0,"PREDICTED: Bubalus bubalis D-amino-acid oxidase (DAO), mRNA","P00371",650,0,"D-amino-acid oxidase","ML2011",136,{"v":2e-33,"d":"2.00E-33"},"COG0665","pfam01266","DAO","FAD dependent oxidoreductase. This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.","GO:0046416|D-amino acid metabolic process;GO:0055114|oxidation-reduction process;","GO:0005777|peroxisome;","GO:0003884|D-amino-acid oxidase activity;GO:0071949|FAD binding;","K00273","DAO, aao; D-amino-acid oxidase [EC:1.4.3.3]"]
["KCNJ1","gene32315",0,0,0,0,0,26,10,13.151405678258,"Inf","Inf",0.0016104877288985,0.0262865133828393,"down","yes","protein_coding","chrNC_037356.1:32212882-32244725:-","gi|529012010|ref|XP_005226881.1|",1898,0,"PREDICTED: ATP-sensitive inward rectifier potassium channel 1 isoform X1 [Bos taurus]","gi|742142755|ref|XM_010844682.1|",3456,0,"PREDICTED: Bison bison bison potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1), transcript variant X1, mRNA","P48048",705,0,"ATP-sensitive inward rectifier potassium channel 1",".",".",".",".","pfam01007","IRK","Inward rectifier potassium channel.","GO:0007588|excretion;GO:0010107|potassium ion import;GO:0006813|potassium ion transport;GO:0034765|regulation of ion transmembrane transport;","GO:0005886|plasma membrane;GO:0008076|voltage-gated potassium channel complex;","GO:0005524|ATP binding;GO:0015272|ATP-activated inward rectifier potassium channel activity;GO:0005242|inward rectifier potassium channel activity;GO:0005546|phosphatidylinositol-4,5-bisphosphate binding;","K04995","KCNJ1; potassium inwardly-rectifying channel subfamily J member 1"]
["C9","gene25616",0,0,0,0,1,18,14,12.0331647703403,"Inf","Inf",0.00162994165430652,0.0264979289681022,"down","yes","protein_coding","chrNC_037347.1:35077223-35144037:+","gi|78369352|ref|NP_001030441.1|",2834,0,"complement component C9 precursor [Bos taurus]","gi|402691864|ref|NM_001035364.2|",2679,0,"Bos taurus complement component 9 (C9), mRNA","Q3MHN2",1096,0,"Complement component C9",".",".",".",".","pfam01823","MACPF","MAC/Perforin domain. The membrane-attack complex (MAC) of the complement system forms transmembrane channels. These channels disrupt the phospholipid bilayer of target cells, leading to cell lysis and death. A number of proteins participate in the assembly of the MAC. Freshly activated C5b binds to C6 to form a C5b-6 complex, then to C7 forming the C5b-7 complex. The C5b-7 complex binds to C8, which is composed of three chains (alpha, beta, and gamma), thus forming the C5b-8 complex. C5b-8 subsequently binds to C9 and acts as a catalyst in the polymerization of C9. Active MAC has a subunit composition of C5b-C6-C7-C8-C9{n}. Perforin is a protein found in cytolytic T-cell and killer cells. In the presence of calcium, perforin polymerizes into transmembrane tubules and is capable of lysing, non-specifically, a variety of target cells. There are a number of regions of similarity in the sequences of complement components C6, C7, C8-alpha, C8-beta, C9 and perforin. The X-ray crystal structure of a MACPF domain reveals that it shares a common fold with bacterial cholesterol dependent cytolysins (pfam01289) such as perfringolysin O. Three key pieces of evidence suggests that MACPF domains and CDCs are homologous: Functional similarity (pore formation), conservation of three glycine residues at a hinge in both families and conservation of a complex core fold.","GO:0001906|cell killing;GO:0006957|complement activation, alternative pathway;GO:0006958|complement activation, classical pathway;GO:0019835|cytolysis;GO:0051260|protein homooligomerization;","GO:0005829|cytosol;GO:0005615|extracellular space;GO:0005579|membrane attack complex;GO:0044218|other organism cell membrane;GO:0005886|plasma membrane;",".","K04000","C9; complement component 9"]
["GSC","gene26589",0,0,0,0,14,10,6,11.0684662832023,"Inf","Inf",0.00206626952586349,0.0315761841684046,"down","yes","protein_coding","chrNC_037348.1:59628000-59629562:-","gi|300798232|ref|NP_001179315.1|",1115,{"v":2e-151,"d":"2.00E-151"},"homeobox protein goosecoid [Bos taurus]","gi|300798231|ref|NM_001192386.1|",774,0,"Bos taurus goosecoid homeobox (GSC), mRNA","Q02591",419,{"v":2e-147,"d":"2.00E-147"},"Homeobox protein goosecoid",".",".",".",".","pfam00046","Homeobox","Homeobox domain.","GO:0009653|anatomical structure morphogenesis;GO:0021904|dorsal/ventral neural tube patterning;GO:0043583|ear development;GO:0048704|embryonic skeletal system morphogenesis;GO:0030900|forebrain development;GO:0042474|middle ear morphogenesis;GO:0048644|muscle organ morphogenesis;GO:0000122|negative regulation of transcription from RNA polymerase II promoter;GO:0030178|negative regulation of Wnt signaling pathway;GO:0014036|neural crest cell fate specification;GO:0023019|signal transduction involved in regulation of gene expression;","GO:0016604|nuclear body;GO:0005634|nucleus;GO:0005667|transcription factor complex;","GO:0000978|RNA polymerase II core promoter proximal region sequence-specific DNA binding;GO:0001103|RNA polymerase II repressing transcription factor binding;GO:0001085|RNA polymerase II transcription factor binding;GO:0001078|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding;","K09324","GSC; homeobox protein goosecoid"]
["PIANP","gene7426",0,0,0,0,16,8,6,11.0820273255931,"Inf","Inf",0.00206822180231228,0.0315763326583654,"down","yes","protein_coding","chrNC_037332.1:103744461-103750919:+","gi|139948710|ref|NP_001077236.1|",900,{"v":5e-111,"d":"5.00E-111"},"PILR alpha-associated neural protein precursor [Bos taurus]","gi|139948709|ref|NM_001083767.1|",2096,0,"Bos taurus PILR alpha associated neural protein (PIANP), mRNA","Q6P1B3",343,{"v":7e-110,"d":"7.00E-110"},"PILR alpha-associated neural protein",".",".",".",".","pfam15298","AJAP1_PANP_C","AJAP1/PANP C-terminus. This family includes the C-terminus of adherens junction-associated protein 1 (AJAP1) and of PILR-associating neural protein (PANP). AJAP1 inhibits cell adhesion and migration. PANP is a ligand for the immune inhibitory receptor paired immunoglobulin-like type 2 receptor alpha.",".","GO:0005912|adherens junction;GO:0016323|basolateral plasma membrane;GO:0016021|integral component of membrane;",".",".","."]
["LOC112442858","gene24719",0,0,0,0,10,12,7,10.6683419488949,"Inf","Inf",0.00241459392481107,0.0352562841703094,"down","yes","snRNA","chrNC_037346.1:43195585-43195775:+","gi|24940209|emb|CAA24954.2|",156,{"v":9e-12,"d":"9.00E-12"},"unnamed protein product [Xenopus laevis]","gi|965960632|ref|XR_001435329.1|",128,{"v":3e-59,"d":"3.00E-59"},"PREDICTED: Ovis aries uncharacterized LOC106991431 (LOC106991431), ncRNA",".",".",".",".",".",".",".",".","pfam01526","DDE_Tnp_Tn3","Tn3 transposase DDE domain. This family includes transposases of Tn3, Tn21, Tn1721, Tn2501, Tn3926 transposons from E-coli. The specific binding of the Tn3 transposase to DNA has been demonstrated. Sequence analysis has suggested that the invariant triad of Asp689, Asp765, Glu895 (numbering as in Tn3) may correspond to the D-D-35-E motif previously implicated in the catalysis of numerous transposases.",".",".",".",".","."]
["ST14","gene32345",0,0,0,0,17,7,3,10.0058891814289,"Inf","Inf",0.00370087648850694,0.0481704868127699,"down","yes","protein_coding","chrNC_037356.1:36351333-36389421:+","gi|115496059|ref|NP_001070006.1|",4317,0,"suppressor of tumorigenicity 14 protein homolog [Bos taurus]","gi|115496058|ref|NM_001076538.1|",1486,0,"Bos taurus suppression of tumorigenicity 14 (ST14), mRNA","Q0IIH7",1663,0,"Suppressor of tumorigenicity 14 protein homolog","mlr3307",117,{"v":3e-27,"d":"3.00E-27"},"COG5640","pfam00089","Trypsin","Trypsin.","GO:0030216|keratinocyte differentiation;","GO:0016021|integral component of membrane;","GO:0004252|serine-type endopeptidase activity;","K08670","ST14, PRSS14; suppressor of tumorigenicity protein 14 [EC:3.4.21.109]"]