{"text_format":"3","workbook":"xlsx","n_sheets":10,"sheets":["Sustaining Proliferative Signal","Evading Growth Suppressor","Resist Cell Death","Enabling Replicative Immortalit","Inducing Angiogenesis","Activating Invasion and Metasta","Genome Instability and Mutation","Tumor promoting Inflammation","Deregulating Cellular Energetic","Avoiding Immune Destruction"],"read":"whole","date_system":"1900"}

{"sheet":"Sustaining Proliferative Signal","index":0,"n_rows":25,"n_cols":9,"rows_kept":25,"merged":[[0,1,0,4],[1,1,1,4],[2,1,2,4],[3,1,3,4],[4,1,4,4],[5,1,5,4],[6,1,6,4],[7,1,7,4],[8,1,8,4],[9,1,9,4],[10,1,10,4],[11,1,11,4],[12,1,12,4],[13,1,13,4],[14,1,14,4],[15,1,15,4],[16,1,16,4],[17,1,17,4],[18,1,18,4],[19,1,19,4],[20,1,20,4],[21,1,21,4],[22,1,22,4],[23,1,23,4],[24,1,24,4]]}
["GO Terms","Name",{"$nulls":3},"GO1","GO2","GO3","GO4"]
["GO:0009967","Positive regulation of signal transduction",{"$nulls":4},"✔️"]
["GO:0030307","Positive regulation of cell growth",{"$nulls":3},"✔️","✔️"]
["GO:0008284","Positive regulation of cell proliferation",{"$nulls":3},"✔️","✔️","✔️"]
["GO:0045787","Positivie regulation of cell cycle",{"$nulls":3},"✔️","✔️","✔️"]
["GO:0007165","Signal transduction",{"$nulls":4},"✔️"]
["GO:0000075","Cell Cycle Checkpoint",{"$nulls":6},"✔️"]
["GO:1901976","regulation of cell cycle checkpoint",{"$nulls":6},"✔️"]
["GO:1901987","regulation of cell cycle phase transition",{"$nulls":6},"✔️"]
["GO:0045786","negative regulation of cell cycle",{"$nulls":5},"✔️","✔️"]
["GO:0050673","epithelial cell proliferation",{"$nulls":6},"✔️"]
["GO:0050678","regulation of epithelial cell proliferation",{"$nulls":6},"✔️"]
["GO:0043616","keratinocyte proliferation",{"$nulls":6},"✔️"]
["GO:0010837","regulation of keratinocyte proliferation",{"$nulls":6},"✔️"]
["GO:0072089","stem cell proliferation",{"$nulls":6},"✔️"]
["GO:0008283","Cell Proliferation",{"$nulls":3},"✔️",null,"✔️"]
["GO:0042127","Regulation of Cell Proliferation",{"$nulls":5},"✔️"]
["GO:0008285","Negative Regulation of Cell Proliferation",{"$nulls":5},"✔️"]
["GO:0007049","Cell Cycle",{"$nulls":3},"✔️",null,"✔️"]
["GO:0051726","Regulation of Cell Cycle",{"$nulls":5},"✔️"]
["GO:0051301","Cell Division",{"$nulls":3},"✔️",null,"✔️"]
["GO:0051302","Regulation of Cell Division",{"$nulls":5},"✔️"]
["GO:0051781","Positive Regulation of Cell Division",{"$nulls":3},"✔️",null,"✔️"]
["GO:0051782","Negative Regulation of Cell Division",{"$nulls":5},"✔️"]
["GO:0016049"," cell growth ",{"$nulls":3},"✔️"]

{"sheet":"Evading Growth Suppressor","index":1,"n_rows":7,"n_cols":8,"rows_kept":7,"merged":[[0,1,0,3],[1,1,1,3],[2,1,2,3],[3,1,3,3],[4,1,4,3],[5,1,5,3],[6,1,6,3]]}
["GO Terms","Name",null,null,"GO1","GO2","GO3","GO4"]
["GO:0009968","Negative regulation of signal transduction",null,null,"✔️","✔️"]
["GO:0030308","Negative regulation of cell growth",null,null,"✔️","✔️"]
["GO:0008285","Negative regulation of cell proliferation",null,null,"✔️","✔️"]
["GO:0045786","Negative regulation of cell cycle",null,null,"✔️","✔️"]
["GO:0007165","Signal transduction",{"$nulls":3},"✔️"]
["GO:0051782"," negative regulation of cell division",null,null,"✔️"]

{"sheet":"Resist Cell Death","index":2,"n_rows":11,"n_cols":9,"rows_kept":11,"merged":[[0,1,0,4],[1,1,1,4],[2,1,2,4],[3,1,3,4],[4,1,4,4],[5,1,5,4],[6,1,6,4],[7,1,7,4],[8,1,8,4],[9,1,9,4],[10,1,10,4]]}
["GO Terms","Name",{"$nulls":3},"GO1","GO2","GO3","GO4"]
["GO:0043069","Negative regualtion of programmed cell death",{"$nulls":4},"✔️","✔️"]
["GO:0043066","Negative regulation of apoptosis",{"$nulls":4},"✔️"]
["GO:0045768","Positive regulation of anti-apoptosis",{"$nulls":4},"✔️"]
["GO:0070265","necrotic cell death",{"$nulls":6},"✔️"]
["GO:0010939","regulation of necrotic cell death",{"$nulls":6},"✔️"]
["GO:0097300","programmed necrotic cell death",{"$nulls":6},"✔️"]
["GO:2001233","regulation of apoptotic signaling pathway",{"$nulls":6},"✔️"]
["GO:0012501"," programmed cell death ",{"$nulls":3},"✔️",null,"✔️"]
["GO:0043067"," regulation of programmed cell death",{"$nulls":3},"✔️",null,"✔️"]
["GO:0043068","Positive Regulation of Programmed Cell Death",{"$nulls":5},"✔️"]

{"sheet":"Enabling Replicative Immortalit","index":3,"n_rows":13,"n_cols":9,"rows_kept":13,"merged":[[0,1,0,4],[1,1,1,4],[2,1,2,4],[3,1,3,4],[4,1,4,4],[5,1,5,4],[6,1,6,4],[7,1,7,4],[8,1,8,4],[9,1,9,4],[10,1,10,4],[11,1,11,4],[12,1,12,4]]}
["GO Terms","Name",{"$nulls":3},"GO1","GO2","GO3","GO4"]
["GO:0001302","Replicative cell aging",{"$nulls":3},"✔️","✔️"]
["GO:0032206","Positive regualtion of telomere maintenance",{"$nulls":4},"✔️"]
["GO:0090398","Cellular senescence",{"$nulls":3},"✔️","✔️","✔️"]
["GO:0000723","telomere maintenance",{"$nulls":3},"✔️",null,"✔️","✔️"]
["GO:0007004","telomere maintenance via telomerase",{"$nulls":6},"✔️"]
["GO:0032204","regulation of telomere maintenance",{"$nulls":3},"✔️",null,"✔️","✔️"]
["GO:0051972","regulation of telomere activity",{"$nulls":6},"✔️"]
["GO:2000772","Regulation of cellular senescence",{"$nulls":3},"✔️",null,"✔️"]
["GO:0007569","Cell Aging",{"$nulls":5},"✔️"]
["GO:0090342","Regulation of cell aging",{"$nulls":5},"✔️"]
["GO:0032200","telomere Organization",{"$nulls":3},"✔️",null,"✔️"]
["GO:1900062"," regulation of replicative cell aging ",{"$nulls":3},"✔️"]

{"sheet":"Inducing Angiogenesis","index":4,"n_rows":24,"n_cols":9,"rows_kept":24,"merged":[[0,1,0,4],[1,1,1,4],[2,1,2,4],[3,1,3,4],[4,1,4,4],[5,1,5,4],[6,1,6,4],[7,1,7,4],[8,1,8,4],[9,1,9,4],[10,1,10,4],[11,1,11,4],[12,1,12,4],[13,1,13,4],[14,1,14,4],[15,1,15,4],[16,1,16,4],[17,1,17,4],[18,1,18,4],[19,1,19,4],[20,1,20,4],[21,1,21,4],[22,1,22,4],[23,1,23,4]]}
["GO Terms","Names",{"$nulls":3},"GO1","GO2","GO3","GO4"]
["GO:0045766","Positive regulation of angiogenesis",{"$nulls":3},"✔️","✔️",null,"✔️"]
["GO:0045765","Regulation of angiogenesis",{"$nulls":4},"✔️"]
["GO:0030949","Positive regulation of vascular endothelial growth factor receptor signaling pathway",{"$nulls":4},"✔️"]
["GO:0001570","Vasculogenesis",{"$nulls":3},"✔️","✔️"]
["GO:0001525","angiogenesis ",{"$nulls":3},"✔️",null,null,"✔️"]
["GO:0045446","Endothelial Cell Differentiation",{"$nulls":5},"✔️"]
["GO:0045601","Regulation of Endothelial Cell Differentiation",{"$nulls":5},"✔️"]
["GO:0045603","Positive Regulation of Endothelial Cell Differentiation",{"$nulls":5},"✔️"]
["GO:0045602","Negative Regulation of Endothelial Cell Differentiation",{"$nulls":5},"✔️"]
["GO:0043542","Endothelial Cell Migration",{"$nulls":5},"✔️"]
["GO:0010594","Regulation of Endothelial Cell Migration",{"$nulls":5},"✔️"]
["GO:0010595","Positive Regulation of Endothelial Cell Migration",{"$nulls":5},"✔️"]
["GO:0010596","Negative Regulation of Endothelial Cell Migration",{"$nulls":5},"✔️"]
["GO:0001944","Vasculature Development",{"$nulls":5},"✔️"]
["GO:1901342","Regulation of Vasculature Development",{"$nulls":5},"✔️"]
["GO:1904018","Positive Regulation of Vasculature Development",{"$nulls":5},"✔️"]
["GO:1901343","Negative Regulation of Vasculature Development",{"$nulls":5},"✔️"]
["GO:0001935","Endothelial Cell Proliferation",{"$nulls":5},"✔️"]
["GO:0001936","Regulation of Endothelial Cell Proliferation",{"$nulls":5},"✔️"]
["GO:0001938","Positive Regulation of Endothelial Cell Proliferation",{"$nulls":5},"✔️"]
["GO:0001937","Negative Regulation of Endothelial Cell Proliferation",{"$nulls":5},"✔️"]
["GO:2001212"," regulation of vasculogenesis ",{"$nulls":3},"✔️"]
["GO:0008015"," blood circulation",{"$nulls":3},"✔️"]

{"sheet":"Activating Invasion and Metasta","index":5,"n_rows":31,"n_cols":9,"rows_kept":31,"merged":[[0,1,0,4],[1,1,1,4],[2,1,2,4],[3,1,3,4],[4,1,4,4],[5,1,5,4],[6,1,6,4],[7,1,7,4],[8,1,8,4],[9,1,9,4],[10,1,10,4],[11,1,11,4],[12,1,12,4],[13,1,13,4],[14,1,14,4],[15,1,15,4],[16,1,16,4],[17,1,17,4],[18,1,18,4],[19,1,19,4],[20,1,20,4],[21,1,21,4],[22,1,22,4],[23,1,23,4],[24,1,24,4],[25,1,25,4],[26,1,26,4],[27,1,27,4],[28,1,28,4],[29,1,29,4],[30,1,30,4]]}
["GO Terms","Name",{"$nulls":3},"GO1","GO2","GO3","GO4"]
["GO:0042060","Wound healing",{"$nulls":4},"✔️"]
["GO:0007162","Negative regulation of cell adhesion",{"$nulls":4},"✔️","✔️"]
["GO:0033631","Cell-cell adhesion mediated by integrin",{"$nulls":4},"✔️"]
["GO:0044331","Cell-cell adhesion mediated by cadherin",{"$nulls":4},"✔️"]
["GO:0001837","Epithelial to mesenchymal transition",{"$nulls":3},"✔️","✔️","✔️"]
["GO:0016477","Cell migration",{"$nulls":3},"✔️","✔️","✔️"]
["GO:0048870","Cell motility",{"$nulls":4},"✔️"]
["GO:0007155","Cell adhesion",{"$nulls":3},"✔️","✔️","✔️"]
["GO:0090130","tissue migration",{"$nulls":6},"✔️"]
["GO:0090132","epithelium migration",{"$nulls":6},"✔️"]
["GO:0010631","epithelial cell migration",{"$nulls":6},"✔️"]
["GO:0010632","regulation of epithelial cell migration",{"$nulls":6},"✔️"]
["GO:0051546","keratinocyte migration",{"$nulls":6},"✔️"]
["GO:0001667","ameboidal-type cell migration",{"$nulls":6},"✔️"]
["GO:0034330","Cell junction Organization",{"$nulls":3},"✔️",null,"✔️"]
["GO:0030030","Cell projection Organization",{"$nulls":3},"✔️",null,"✔️"]
["GO:0031344","Regulation of Cell projection Organization",{"$nulls":5},"✔️"]
["GO:0031346","Positive Regulation of Cell projection Organization",{"$nulls":5},"✔️"]
["GO:0031345","Negative Regulation of Cell projection Organization",{"$nulls":5},"✔️"]
["GO:0010717","Regulation of EMT",{"$nulls":5},"✔️"]
["GO:0010718","Positive Regulation of EMT",{"$nulls":5},"✔️"]
["GO:0010719","Negative Regulation of EMT",{"$nulls":5},"✔️"]
["GO:0030155","Regulation of Cell Adhesion",{"$nulls":3},"✔️",null,"✔️"]
["GO:0045785","Positive Regulation of Cell Adhesion",{"$nulls":5},"✔️"]
["GO:0030334","Regulation of Cell Migration",{"$nulls":5},"✔️"]
["GO:0030335","Positive Regulation of Cell Migration",{"$nulls":5},"✔️"]
["GO:0030336","Negative Regulation of Cell Migration",{"$nulls":5},"✔️"]
["GO:0030036","actin cytoskeleton organization",{"$nulls":3},"✔️"]
["GO:0042330","taxis",{"$nulls":3},"✔️"]
["GO:0007163","establishment or maintenance of",{"$nulls":3},"✔️"]

{"sheet":"Genome Instability and Mutation","index":6,"n_rows":12,"n_cols":9,"rows_kept":12,"merged":[[0,1,0,4],[1,1,1,4],[2,1,2,4],[3,1,3,4],[4,1,4,4],[5,1,5,4],[6,1,6,4],[7,1,7,4],[8,1,8,4],[9,1,9,4],[10,1,10,4],[11,1,11,4]]}
["GO Terms","Name",{"$nulls":3},"GO1","GO2","GO3","GO4"]
["GO:0051276","Chromosome organization",{"$nulls":4},"✔️"]
["GO:0045005","Maintenance of fidelity involved in DNA-dependent DNA replication",{"$nulls":3},"✔️","✔️"]
["GO:0006281","DNA repair",{"$nulls":3},"✔️","✔️","✔️"]
["GO:0006282","regulation of DNA repair",{"$nulls":3},"✔️",null,"✔️","✔️"]
["GO:0006298","mismatch repair",{"$nulls":6},"✔️"]
["GO:0006302","double-strand break repair",{"$nulls":6},"✔️"]
["GO:0006289","nucleotide-excision repair",{"$nulls":6},"✔️"]
["GO:0036297","interstrand cross-link repair",{"$nulls":6},"✔️"]
["GO:0031570","DNA integrity Checkpoint",{"$nulls":3},"✔️",null,"✔️"]
["GO:0045739","Positive Regulation of DNA repair",{"$nulls":5},"✔️"]
["GO:0045738","Negative Regulation of DNA repair",{"$nulls":5},"✔️"]

{"sheet":"Tumor promoting Inflammation","index":7,"n_rows":17,"n_cols":9,"rows_kept":17,"merged":[[0,1,0,4],[1,1,1,4],[2,1,2,4],[3,1,3,4],[4,1,4,4],[5,1,5,4],[6,1,6,4],[7,1,7,4],[8,1,8,4],[9,1,9,4],[10,1,10,4],[11,1,11,4],[12,1,12,4],[13,1,13,4],[14,1,14,4],[15,1,15,4],[16,1,16,4]]}
["GO Terms","Name",{"$nulls":3},"GO1","GO2","GO3","GO4"]
["GO:0002419","T-cell mediated cytotoxicity directed against tumor cell target",{"$nulls":4},"✔️"]
["GO:0002420","Natural killer cell mediated cytotoxicity directed against tumor cell target",{"$nulls":4},"✔️"]
["GO:0002857","Positive regualtion of natural killer cell mediated immune response to tumor cell",{"$nulls":4},"✔️"]
["GO:0002842","Positive regualtion of T-cell mediated immune response to tumor cell",{"$nulls":4},"✔️"]
["GO:0002367","Cytokine production involved in immune response",{"$nulls":3},"✔️","✔️"]
["GO:0050776","Regulation of immune response",{"$nulls":4},"✔️"]
["GO:0002526","acute inflammatory response",{"$nulls":6},"✔️"]
["GO:0002544","chronic inflammatory response",{"$nulls":6},"✔️"]
["GO:0050727","regulation of inflammatory response",{"$nulls":3},"✔️",null,null,"✔️"]
["GO:0050900","Leukocyte Migration",{"$nulls":5},"✔️"]
["GO:0002685","Regulation of Leukocyte Migration ",{"$nulls":5},"✔️"]
["GO:0006954"," inﬂammatory response ",{"$nulls":3},"✔️"]
["GO:0002718"," regulation of cytokine production involved in immune response ",{"$nulls":3},"✔️"]
["GO:0042060"," wound healing ",{"$nulls":3},"✔️"]
["GO:0061041"," regulation of wound healing ",{"$nulls":3},"✔️"]
["GO:0042533"," tumor necrosis factor biosynthetic process",{"$nulls":3},"✔️"]

{"sheet":"Deregulating Cellular Energetic","index":8,"n_rows":6,"n_cols":9,"rows_kept":6,"merged":[[0,1,0,4],[1,1,1,4],[2,1,2,4],[3,1,3,4],[4,1,4,4],[5,1,5,4]]}
["GO Terms","Name",{"$nulls":3},"GO1","GO2","GO3","GO4"]
["GO:0006096","Glycolysis",{"$nulls":3},"✔️","✔️",null,"✔️"]
["GO:0071456","Cellular response to hypoxia",{"$nulls":3},"✔️","✔️"]
["GO:0006110","regulation of glycolytic process",{"$nulls":6},"✔️"]
["GO:0006006"," glucose metabolic process ",{"$nulls":3},"✔️"]
["GO:0046323"," glucose import ",{"$nulls":3},"✔️"]

{"sheet":"Avoiding Immune Destruction","index":9,"n_rows":10,"n_cols":9,"rows_kept":10,"merged":[[0,1,0,4],[1,1,1,4],[2,1,2,4],[3,1,3,4],[4,1,4,4],[5,1,5,4],[6,1,6,4],[7,1,7,4],[8,1,8,4],[9,1,9,4]]}
["GO Terms","Name",{"$nulls":3},"GO1","GO2","GO3","GO4"]
["GO:0002837","Regulation of immune response to tumor cell",{"$nulls":3},"✔️","✔️"]
["GO:0002418","Immune response to tumor cells",{"$nulls":3},"✔️","✔️"]
["GO:0002367","Cytokine production involved in immune response",{"$nulls":4},"✔️"]
["GO:0050776","Regulation of immune response",{"$nulls":4},"✔️","✔️"]
["GO:0006955","Immune Response",{"$nulls":3},"✔️",null,"✔️"]
["GO:0050778","Positive Regulation of Immune Response",{"$nulls":5},"✔️"]
["GO:0050777","Negative Regulation of Immune Response",{"$nulls":5},"✔️"]
["GO:0020012"," evasion or tolerance of host immune response",{"$nulls":3},"✔️"]
["GO:0006897"," endocytosis",{"$nulls":3},"✔️"]