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["Appendix Table 2. The identified proteins with decreased expression between str.200502 and str. 56601 "]
["Uniprot ID","Gene name","Protein name","Mass","pI","Subcellular location predicted","Type of secretion predicted\n","Fold change (str.200502/56601)","p_value"]
["A0A098MK28","acsA","Acetyl-coenzyme A synthetase",73.3,8.94,"Cytoplasmic","Undefined",{"v":0.754476316,"d":"0.75"},5.82e-29]
["A0A098MSX2","IQ65_14915","Uncharacterized protein",8.7,7.2,"Cytoplasmic","Non-classical",{"v":0.7713,"d":"0.77"},0.002563023]
["A0A098MTW9","IQ65_12825","Molecular chaperone Hsp20",15.6,6.8,"Cytoplasmic","Undefined",{"v":0.728168182,"d":"0.73"},1.49e-17]
["A0A098MVA6","IQ65_12740","Transketolase",34.2,6.24,"Cytoplasmic","Undefined",{"v":0.361625,"d":"0.36"},0.006685358]
["A0A098MVP5","IQ65_11450","Uncharacterized protein",17.8,7.09,"Cytoplasmic","Classical",{"v":0.4853,"d":"0.49"},2.95e-07]
["A0A098MWR2","IQ65_12745","Transketolase",28.8,8.13,"Cytoplasmic","Undefined",{"v":0.404245833,"d":"0.40"},2.2e-26]
["A0A098MX64","IQ65_08665","Esterase",41.4,6.3,"Extracellular","Classical",{"v":0.395769048,"d":"0.40"},2.38e-33]
["A0A098N1G0","IQ65_05660","Uncharacterized protein",29,9.58,"Cytoplasmic","Undefined",{"v":0.777783721,"d":"0.78"},1.61e-28]
["A0A0C5WQC2","aceF2","Acetyltransferase component of pyruvate dehydrogenase complex",48.6,6.83,"Cytoplasmic","Undefined",{"v":0.32555,"d":"0.33"},0.011863676]
["A0A0E2AXK1","LEP1GSC081_0203","Adenylate/guanylate cyclase catalytic domain protein",55.2,5.64,"Cytoplasmic","Undefined",{"v":0.674364286,"d":"0.67"},4.81e-11]
["A0A0E2AYG6","LEP1GSC081_0018","ParB-like protein",33.4,9.58,"Cytoplasmic","Undefined",{"v":0.6861,"d":"0.69"},0.004741692]
["A0A0E2AYJ5","LEP1GSC081_0302","PAS domain S-box protein",54.9,5.68,"CytoplasmicMembrane","Undefined",{"v":0.792675,"d":"0.79"},0.003665839]
["A0A0E2B4V5","LEP1GSC081_3503","Metallopeptidase family M24",49.2,6.09,"Cytoplasmic","Undefined",{"v":0.40205,"d":"0.40"},0.009160381]
["A0A0E2CK57","LEP1GSC087_1880","Uncharacterized protein",75,8.69,"CytoplasmicMembrane","Classical",{"v":0.737486607,"d":"0.74"},6.85e-59]
["A0A0E2CKQ0","LEP1GSC087_1341","LemA domain protein ",7.2,5.19,"CytoplasmicMembrane","Undefined",{"v":0.7981,"d":"0.80"},0.001584634]
["A0A0E2CWM6","LEP1GSC087_3116","Putative type II secretion system protein D",66.4,8.34,"OuterMembrane","Classical",{"v":0.7880375,"d":"0.79"},0.001059526]
["A0A0E2CZ76","LEP1GSC087_0983","Inorganic anion transporter, SulP family",83.2,6.84,"CytoplasmicMembrane","Undefined",{"v":0.6715875,"d":"0.67"},3.76e-10]
["A0A0E2D2V7","LEP1GSC105_0566","Putative lipoprotein",26.6,6.61,"Cytoplasmic","Classical",{"v":0.700585714,"d":"0.70"},0.002642796]
["A0A0E2DCT0","LEP1GSC105_0665","Alpha/beta hydrolase family protein",32,9.03,"Cytoplasmic","Undefined",{"v":0.640978378,"d":"0.64"},1.52e-34]
["A0A0E3B331","LBBP_04239","Uncharacterized protein",20.9,8.21,"CytoplasmicMembrane","Classical",{"v":0.639877778,"d":"0.64"},0.002809261]
["A0A0F6H3X4","tsf","Elongation factor Ts OS=Leptospira interrogans",22.1,5.85,"Cytoplasmic","Undefined",{"v":0.3807,"d":"0.38"},3.53e-05]
["A0A0F6H4T2","LEP1GSC104_0197","KR domain protein",29.8,9.67,"Cytoplasmic","Undefined",{"v":0.7808875,"d":"0.78"},9.1e-06]
["A0A0F6H728","LEP1GSC104_2218","Uncharacterized protein",12.7,5.6,"Cytoplasmic","Undefined",{"v":0.786571429,"d":"0.79"},0.0232712]
["A0A0F6H8K5","LEP1GSC104_0746","PAS domain S-box protein",27.7,6.9,"Cytoplasmic","Undefined",{"v":0.4118,"d":"0.41"},2.06e-31]
["A0A0F6HDS0","ctaD","Alpha/beta hydrolase family protein",38.4,8.85,"Cytoplasmic","Undefined",{"v":0.4558,"d":"0.46"},0.005726688]
["A0A0F6HGG3","LEP1GSC104_2078","3-demethylubiquinone-9 3-methyltransferase domain protein",15.5,5.15,"Cytoplasmic","Undefined",{"v":0.539575,"d":"0.54"},0.001563155]
["A0A0F6HXF1","LEP1GSC025_4792","Uncharacterized protein",46.9,5.05,"Extracellular","Classical",{"v":0.25378,"d":"0.25"},1.22e-05]
["A0A0F6I2X3","LEP1GSC025_1932","Rhodanese-like protein",31.8,9.09,"Cytoplasmic","Non-classical",{"v":0.781148571,"d":"0.78"},7.05e-29]
["A0A0F6I6C3","LEP1GSC025_2046","Stage II sporulation protein E",201.5,6.14,"Cytoplasmic","Undefined",{"v":0.440923529,"d":"0.44"},8.98e-26]
["A0A0F6I6L5","LEP1GSC025_2026","PF07598 family protein",71.9,8.75,"CytoplasmicMembrane","Classical",{"v":0.556983333,"d":"0.56"},3.39e-12]
["A0A0F6I776","LEP1GSC025_2306","Oxidoreductase, zinc-binding dehydrogenase family protein",37.3,9.39,"Cytoplasmic","Undefined",{"v":0.6103,"d":"0.61"},0.021831217]
["A0A0F6I855","LEP1GSC079_2142","Response regulator receiver domain protein ",17,4.75,"Cytoplasmic","Undefined",{"v":0.775509091,"d":"0.78"},7.27e-08]
["A0A0F6I9K1","cheY","Chemotaxis protein CheY",13.3,5.6,"Cytoplasmic","Undefined",{"v":0.780989583,"d":"0.78"},1.11e-26]
["A0A0F6IFM2","gcvP","Glycine dehydrogenase (decarboxylating)",106.2,6.57,"Cytoplasmic","Undefined",{"v":0.3702,"d":"0.37"},0.010604157]
["A0A0F6IG29","LEP1GSC079_1402","Response regulator receiver domain protein",26.3,7.58,"Cytoplasmic","Undefined",{"v":0.54465,"d":"0.54"},0.007021171]
["A0A0F6IGP8","LEP1GSC079_4246","Response regulator receiver domain protein",27.7,5.81,"Cytoplasmic","Undefined",{"v":0.7828,"d":"0.78"},1.09e-05]
["A0A0F6IGX1","LEP1GSC079_4195","Uncharacterized protein",14.2,8.66,"CytoplasmicMembrane","Classical",{"v":0.795383333,"d":"0.80"},2.4e-06]
["A0A0F6IIH7","LEP1GSC079_2333","Carboxypeptidase regulatory-like domain protein",110.4,9.04,"OuterMembrane","Classical",{"v":0.78993992,"d":"0.79"},2.43e-219]
["A0A0S2IXZ3","LBBP_04331","Adenosylmethionine decarboxylase",10.8,7.02,"Cytoplasmic","Non-classical",{"v":0.747128571,"d":"0.75"},1.17e-05]
["A0A150FDY1","WP_025182121","Uncharacterized protein",18.1,8.98,"Unknown","Non-classical",{"v":0.522528571,"d":"0.52"},1.28e-05]
["A0A161Q749"," WP_000055092","Monooxygenase",54.4,9,"Cytoplasmic","Classical",{"v":0.48845,"d":"0.49"},0.004314236]
["A0A161S2H7","WP_000653652","3-oxoacyl-ACP reductase",27.1,7.83,"Cytoplasmic","Undefined",{"v":0.7212,"d":"0.72"},1.64e-06]
["A0A163NN49","WP_001230740","Chemotaxis protein",62.8,6.07,"Cytoplasmic","Undefined",{"v":0.593401587,"d":"0.59"},2.35e-51]
["A0A163R2Q7","WP_002071555","ArsC family transcriptional regulator",13.6,9.54,"Cytoplasmic","Non-classical",{"v":0.721371429,"d":"0.72"},9.2e-05]
["A0A163RHH0","AAS72055","3-ketoacyl-ACP reductase",26.9,10.05,"Cytoplasmic","Undefined",{"v":0.785981818,"d":"0.79"},1.47e-07]
["A0A163RJL0"," WP_000875950","DUF2505 domain-containing protein",18.5,6.81,"Cytoplasmic","Undefined",{"v":0.709129412,"d":"0.71"},3.53e-10]
["A0A1D7UVX6","A0128_07820","Cysteine synthase",33.2,7.58,"Cytoplasmic","Undefined",{"v":0.417461538,"d":"0.42"},3.01e-11]
["A0A1R0JL10","WP_000721319","Uncharacterized protein",22.6,6.25,"CytoplasmicMembrane","Classical",{"v":0.5549,"d":"0.55"},0.037836366]
["A0A1R0JSF6","WP_000034361","Dehydratase",15.1,7.33,"Cytoplasmic","Non-classical",{"v":0.790185714,"d":"0.79"},4.42e-09]
["A0A1R0JWH0","WP_001271669","Dihydrolipoyl dehydrogenase",50.2,7.14,"Cytoplasmic","Undefined",{"v":0.55825,"d":"0.56"},0.013610541]
["A0A1V2ZJ45","WP_082267566","Long-chain fatty acid--CoA ligase",76.1,8.72,"Cytoplasmic","Undefined",{"v":0.209675,"d":"0.21"},1.07e-06]
["A0A1V2ZJR9","WP_082267546","Chemotaxis response regulator protein-glutamate methylesterase",38.6,6.65,"Cytoplasmic","Undefined",{"v":0.7738,"d":"0.77"},3.29e-06]
["A0A1X8WHA4","GNX_4316","Uncharacterized protein",20.3,8.66,"Cytoplasmic","Non-classical",{"v":0.7484,"d":"0.75"},0.000577696]
["A0A1X8WK24","GNX_3492","PAS domain protein",36,4.84,"CytoplasmicMembrane","Non-classical",{"v":0.7609,"d":"0.76"},0.014813626]
["A0A1X8WKC7","GNX_3212","Serine acetyltransferase",23,9.51,"Cytoplasmic","Undefined",{"v":0.791328571,"d":"0.79"},0.000141877]
["A0A1X8WMA5","GNX_2483","Sphingomyelinase C 1",49,8.48,"Extracellular","Non-classical",{"v":0.5967,"d":"0.60"},0.001252142]
["A0A1X8WPU0","GNX_1836","Uncharacterized protein",25.8,5.05,"Cytoplasmic","Undefined",{"v":0.48818,"d":"0.49"},7.62e-07]
["A0A2H1XCE8","LMANV2_220053","Glycosyl hydrolase, family 18",50.4,8.73,"Cytoplasmic","Classical",{"v":0.6799,"d":"0.68"},5.27e-06]
["A0A2H1XG76","LMANV2_420005","Uncharacterized protein",39.1,5.4,"Cytoplasmic","Classical",{"v":0.78620625,"d":"0.79"},1.36e-57]
["M3CSR8","LEP1GSC067_2800","Uncharacterized protein",13.5,7.33,"Cytoplasmic","Undefined",{"v":0.4963,"d":"0.50"},4.17e-07]
["M3EAR6","LEP1GSC067_1643","Glycosyltransferase, group 1 family protein",33.3,9.35,"Cytoplasmic","Undefined",{"v":0.4076,"d":"0.41"},0.009427845]
["M3GCE6","LEP1GSC150_2941","Uncharacterized protein",68.1,5.17,"Cytoplasmic","Undefined",{"v":0.703425,"d":"0.70"},0.002632266]
["M3H0Z2","LEP1GSC151_0685","RmlD substrate binding domain protein",7.1,7.18,"Cytoplasmic","Undefined",{"v":0.7841,"d":"0.78"},0.03404529]
["M3HKM2","EMF98209","Cytochrome c oxidase subunit 1",82.5,8.38,"CytoplasmicMembrane","Undefined",{"v":0.461588235,"d":"0.46"},5.13e-08]
["M3ICM2","pheT","Phenylalanine--tRNA ligase beta subunit",70.9,6.74,"Cytoplasmic","Undefined",{"v":0.490475,"d":"0.49"},4.56e-05]
["M3IPI5","LEP1GSC150_2939","Uncharacterized protein",32.3,5.63,"Cytoplasmic","Undefined",{"v":0.566966667,"d":"0.57"},0.003261514]
["M6CXG2","LEP1GSC194_3287","Stage II sporulation protein E",65.8,5.71,"Cytoplasmic","Undefined",{"v":0.6674,"d":"0.67"},0.037060134]
["M6DMP6"," WP_000409183","Uncharacterized protein",20.2,10.1,"Cytoplasmic","Non-classical",{"v":0.720776786,"d":"0.72"},5.93e-31]
["M6E353"," WP_020765843","Papain family cysteine protease",87.4,8.66,"Cytoplasmic","Classical",{"v":0.68985,"d":"0.69"},0.033767845]
["M6EA23","WP_004750086","Uncharacterized protein",12.7,9.2,"Cytoplasmic","Undefined",{"v":0.39669375,"d":"0.40"},2.74e-17]
["M6EBU4","LEP1GSC104_3204","PF14346 domain protein",61.9,5.74,"Cytoplasmic","Classical",{"v":0.453255556,"d":"0.45"},1.38e-07]
["M6FPV5","pheS","Phenylalanine--tRNA ligase alpha subunit",38.6,6.55,"Cytoplasmic","Undefined",{"v":0.7751,"d":"0.78"},9.01e-05]
["M6GJ67","LEP1GSC037_1765","Uncharacterized protein",7.6,6.51,"CytoplasmicMembrane","Undefined",{"v":0.6287,"d":"0.63"},0.006383959]
["M6H071","LEP1GSC037_4214","Saccharopine dehydrogenase domain protein",37,9.35,"Cytoplasmic","Undefined",{"v":0.65102,"d":"0.65"},8.67e-06]
["M6H937","LEP1GSC158_4770","Alpha/beta hydrolase family protein",29.1,7.59,"Cytoplasmic","Undefined",{"v":0.6601125,"d":"0.66"},3.77e-08]
["M6HC30","LEP1GSC158_1792","Membrane-bound O-acyltransferase family MBOAT",34.7,9.22,"CytoplasmicMembrane","Classical",{"v":0.695128571,"d":"0.70"},3.78e-07]
["M6HDR3","LEP1GSC158_0207","Stage II sporulation protein E",64.9,5.02,"Cytoplasmic","Undefined",{"v":0.69605,"d":"0.70"},8.99e-05]
["M6HJZ7","LEP1GSC158_5065","GHKL domain protein",56.4,6.76,"CytoplasmicMembrane","Undefined",{"v":0.596566667,"d":"0.60"},1.62e-07]
["M6K2V0","LEP1GSC083_4026","DJ-1/PfpI domain protein",18,9.39,"Cytoplasmic","Undefined",{"v":0.633075,"d":"0.63"},0.00226546]
["M6K361","LEP1GSC083_3290","Polysaccharide deacetylase",35,9.41,"Cytoplasmic","Non-classical",{"v":0.791330769,"d":"0.79"},1.53e-05]
["M6K3Y0","LEP1GSC083_4349","GMC oxidoreductase ",49.8,8.94,"Cytoplasmic","Undefined",{"v":0.77845,"d":"0.78"},0.009204092]
["M6K6U7","LEP1GSC083_1321","Methionine biosynthesis protein MetW-like protein",25.9,5.9,"Cytoplasmic","Undefined",{"v":0.397775,"d":"0.40"},0.00246821]
["M6K8X1","LEP1GSC083_0016","Uncharacterized protein",14,6.54,"Cytoplasmic","Undefined",{"v":0.709333333,"d":"0.71"},0.021875757]
["M6KBZ3","LEP1GSC083_4131","Uncharacterized protein",21.4,6.14,"Cytoplasmic","Classical",{"v":0.592633333,"d":"0.59"},0.005619427]
["M6LGB0","LEP1GSC086_2660","DNA topoisomerase (ATP-hydrolyzing)",54,8.51,"Cytoplasmic","Undefined",{"v":0.7421,"d":"0.74"},0.00010311]
["M6R4Y9","LEP1GSC116_4334","PF03961 family protein",44.6,8.94,"Cytoplasmic","Undefined",{"v":0.7467,"d":"0.75"},6.73e-05]
["M6RAK1","LEP1GSC116_5071","MazG family protein",25.4,6.01,"Cytoplasmic","Undefined",{"v":0.6597,"d":"0.66"},0.00037455]
["M6RD85","LEP1GSC116_5125","DNA-binding helix-turn-helix protein",28.4,9.63,"CytoplasmicMembrane","Undefined",{"v":0.7508,"d":"0.75"},0.042285212]
["M6REV8","sppA_2","Signal peptide peptidase SppA, 36K type",33.9,7.31,"CytoplasmicMembrane","Undefined",{"v":0.749278261,"d":"0.75"},3.4e-21]
["M6S384","LEP1GSC116_0570","S1/P1 Nuclease",30.6,7.9,"Cytoplasmic","Undefined",{"v":0.397223256,"d":"0.40"},1.33e-28]
["M6T6M4","LEP1GSC170_5630","Beta-ketoacyl synthase, N-terminal domain protein",44.7,6.71,"CytoplasmicMembrane","Undefined",{"v":0.70516,"d":"0.71"},0.013860649]
["M6TBL2","LEP1GSC170_2679","Transporter, SSS family",65.5,8.9,"CytoplasmicMembrane","Undefined",{"v":0.7237,"d":"0.72"},0.022581061]
["M6V8N1","LEP1GSC172_1204","Uncharacterized protein",6.3,9,"Cytoplasmic","Non-classical",{"v":0.71155,"d":"0.71"},0.030310224]
["M6VD63","WP_002763946","Flagellin",31.1,8.81,"Extracellular","Undefined",{"v":0.7179,"d":"0.72"},0.011199934]
["M6ZK68","LEP1GSC124_1010","Lysine decarboxylase domain protein",12.7,5.91,"Cytoplasmic","Undefined",{"v":0.72245,"d":"0.72"},0.034815847]
["M6ZKS9","LEP1GSC124_2572","CBS domain protein",27.5,8.09,"CytoplasmicMembrane","Undefined",{"v":0.7942,"d":"0.79"},4.31e-06]
["M7A0L5","LEP1GSC124_2026","UPF0109 protein LEP1GSC124_2026",8.4,5.15,"Cytoplasmic","Undefined",{"v":0.765245,"d":"0.77"},9.85e-07]
["M7A1H3","LEP1GSC124_0254","Uncharacterized protein",11.8,8.41,"Cytoplasmic","Non-classical",{"v":0.5195,"d":"0.52"},0.001973124]
["M7A3B7","LEP1GSC124_0348","TIGR02300-like family protein",14.5,5.08,"Cytoplasmic","Undefined",{"v":0.7781625,"d":"0.78"},8.97e-14]
["N1UA89","LEP1GSC043_4367","TonB-dependent receptor",11,8.16,"CytoplasmicMembrane","Undefined",{"v":0.766,"d":"0.77"},0.010520476]
["N1UGA7","def","Peptide deformylase",19.4,4.98,"Cytoplasmic","Undefined",{"v":0.777108333,"d":"0.78"},4.71e-05]
["N1UWN3","LEP1GSC115_5539","PF09917 family protein",15.8,8.69,"Cytoplasmic","Non-classical",{"v":0.55235,"d":"0.55"},2.76e-05]
["N1UXW1","LEP1GSC115_4542","CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP-like protein",20.3,9.1,"Cytoplasmic","Undefined",{"v":0.75125,"d":"0.75"},0.006050943]
["N1WFQ2","LEP1GSC060_3546","SPFH domain/Band 7 family protein",31,7.25,"Cytoplasmic","Classical",{"v":0.7613,"d":"0.76"},0.007912236]
["Q72MI1","LIC_13206","Uncharacterized protein",17.6,8.72,"Cytoplasmic","Non-classical",{"v":0.7982,"d":"0.80"},0.000210366]
["Q72PZ2","LIC_12323","Type III beta-ketoacyl synthase-like protein",31,6.25,"Cytoplasmic","Non-classical",{"v":0.553133333,"d":"0.55"},0.000104206]
["Q8EYQ7","ccmA","ATP-binding protein of an ABC transporter complex",34.9,7.39,"Cytoplasmic","Undefined",{"v":0.658853012,"d":"0.66"},1.43e-49]
["Q8F3W6","purH","Bifunctional purine biosynthesis protein PurH",56.3,6.61,"Cytoplasmic","Undefined",{"v":0.771855556,"d":"0.77"},9.37e-26]
["Q8F847","LA_0712","Putative lipoprotein",24.4,5.74,"Cytoplasmic","Classical",{"v":0.413216667,"d":"0.41"},7.73e-07]
["Q8F8T9","ribH","6,7-dimethyl-8-ribityllumazine synthase",15.9,6.93,"Cytoplasmic","Undefined",{"v":0.52255,"d":"0.52"},0.003707099]
["Q8F9R2","LA_0129","Uncharacterized protein",70.3,8.82,"Cytoplasmic","Undefined",{"v":0.72886,"d":"0.73"},3.01e-19]
["Q9XD18","rpmD","50S ribosomal protein L30",6.7,11.17,"Cytoplasmic","Undefined",{"v":0.428775,"d":"0.43"},0.02359753]
["S3V0B2","LEP1GSC058_3725","Dehydratase MaoC metal-binding domain protein",17.1,6.19,"Cytoplasmic","Undefined",{"v":0.7402,"d":"0.74"},0.026237757]
["T0FHR3","LEP1GSC050_1159","Membrane-bound O-acyltransferase family MBOAT",54.3,9.14,"CytoplasmicMembrane","Undefined",{"v":0.785,"d":"0.79"},0.002911942]
["T0GS40","LEP1GSC059_4227","DEAD/DEAH box helicase",57.5,9.1,"Cytoplasmic","Undefined",{"v":0.7715,"d":"0.77"},1.68e-27]
[]
["Undefined:No signal-peptide was predicted and the SecretomeP analysis was negative\nClassical:signal-peptide was identified in at least two software\nUnclassical:SecretomeP analysis was positive and one or none signal-peptide was identified."]

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