Chromatin supplement (draft v3 layout; results/182/182_FigS_chromatin_v3). Groups and data as Fig. 6; HPC is shown in Fig. 6 and is not repeated in A and C.
(A) H3K4me3 and H3K27me3 signal around the TSS in T and B cells (separate y scales; bands, gene-level 95% intervals). (B) Mean signal within TSS +/- 2.5 kb by expression tertile (Corces TPM within the cell) in HPC, T and B cells; open symbol, fewer than 30 genes; bars, gene-level 95% intervals (Data S2, Table 1b).
(C) CpG methylation around the TSS in T and B cells, as Fig. 6B (dotted line, 50%; ticks, median TSS-to-edge distance). (D) Methylation rise in HPC: Kaplan-Meier fraction of sides risen by distance from the TSS; lines, expression tertiles (bottom light, middle, top full colour); ticks on the x axis, tertile KM medians (as Fig. 6C); dotted line, median TSS-to-edge distance of the group; dashed line, median TSS-to-nearest-retroelement distance (not shown when > 5 kb); thin line with n, fewer than 50 sides.
