A05 Hauser 2022 functional-repertoire finalization
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Purpose
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Descriptive report, requested during earlier peer review, of how many of the 207
structural receptor-transducer units come from receptors with more than one
analyzed functional G-protein coupling class.

External source
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Hauser AS et al. (2022), Common coupling map advances GPCR-G protein selectivity,
eLife 11:e74107, Source Data 5.

Source Data 5 sheet: Merged_couplings.
The family support columns used are Gs.1, Gi/o, Gq/11 and G12/13.
These reproduce the paper's reported supported-family totals:
Gs=87, Gi/o=176, Gq/11=134, G12/13=49.

Mapping policy
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Mapping is by exact UniProt accession from the structural archive to the human
receptor reference table in Source Data 5. Non-human and viral receptor structures
are NOT projected onto human orthologs. Their functional repertoire is left unknown.

Interpretation policy
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A value of 1 means that Hauser et al.'s common map supports that family coupling.
An absent support flag is treated only as "not supported in this common map",
not as proof of biological non-coupling. This analysis is descriptive only and
is not used as a classifier or as a source of negative labels.

Primary count
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101 of 207 structural units
(48.8% of all units)
are from receptors directly mapped to Hauser et al. that support >=2 of the three
modeled families (Gs, Gi/o, Gq/11).

Among the 190 directly mapped units, this is
53.2%.
These units represent 76 of
156 directly mapped receptors.

The remaining 17 units correspond to
13 non-human or viral receptors and are left unannotated.
