A. human cells vs organismal consensus, by category
                            category    n  concordant  share  binom_p_two_sided  disc_cellAP_orgAR  disc_cellAR_orgAP  q_BH_8categories
0                                All  236         126  0.534              0.329                 59                 51               NaN
1        Growth & nutrient signaling   13           8  0.615              0.581                  4                  1             0.775
2               Mitochondria & redox   44          32  0.727              0.004                  8                  4             0.015
3           Autophagy & proteostasis   33          27  0.818              0.000                  0                  6             0.003
4              Cell-death regulation   81          51  0.630              0.026                 15                 15             0.068
5  Chromatin & epigenetic regulation   43          24  0.558              0.542                  8                 11             0.775
6     DNA damage, repair & telomeres   49          28  0.571              0.392                 10                 11             0.775
7    Cell-cycle arrest & checkpoints   26          14  0.538              0.845                  7                  5             0.966
8                SASP & inflammation   35          18  0.514              1.000                  9                  8             1.000
arrest/SASP union n=59 same=30 share=0.508; Fisher growth vs arrest/SASP OR=1.55 p=0.551
maintenance union n=63 same=46 share=0.730; Fisher maintenance vs arrest/SASP OR=2.62 p=0.0151
genes in both groups 18
A2 1 organism 185 92 0.497 1.0
A2 >=2 organisms 51 34 0.667 0.024092907698449295
A2 Fisher multi vs single organism OR=2.02 p=0.0391
A3 discordant: cell AP/org AR 59  cell AR/org AP 51 0.5046848075879908
B. RLS n=895 CLS n=1360 universe=4107 overlap=511 expected=296.4 fold=1.72 p=1.52e-63; resolved=428 same=212 share=0.495 binom2=0.885
B2 Yeast RLS vs animal consensus: n=184 same=124 share=0.674 p2=2.74e-06
B2 Yeast CLS vs animal consensus: n=246 same=123 share=0.500 p2=1
C1 concordant in >=2 of yeast/worm/fly, mouse ortholog, no mouse lifespan data: 180 {'AP': 92, 'AR': 88}  of which 3 organisms: 12
C2 back-test, invertebrate-concordant genes tested in mouse: 14 same 13 0.929 0.00091552734375
C3 back-test vs human cells: 39 same 24 0.615 0.09979543345980349
C2 genes:         human  Yeast   Worm  Fly Mouse
229      ATG5     AR     AR  NaN    AR
1040      FXN     AR  mixed   AR    AR
1382    IGF1R    NaN     AP   AP    AP
1411     INSR    NaN     AP   AP    AP
1757     MSRA     AR    NaN   AR    AR
1787     MTOR     AP     AP   AP    AP
2278    PRDX1     AR     AR   AR    AR
2355     PTEN    NaN     AR   AR    AR
2596  RPS6KB1     AP     AP   AP    AP
2707    SIRT1  mixed     AR   AR    AR
2724  SLC13A1     AP     AP   AP    AP
2756  SLC25A4     AP     AP  NaN    AR
2879     SOD2     AR  mixed   AR    AR
3182      TXN     AR     AR   AR    AR
C4 single invertebrate organism vs mouse: 31 19 0.613
C5 concordant invertebrate genes untested in CellAge: 160
         human  Yeast   Worm  Fly Mouse Human cells inv_dir  inv_n                                                                 stages
224       ATG3     AR     AR   AR   NaN         NaN      AR      3                         Autophagy & proteostasis; Mitochondria & redox
920       ERN1     AR     AR   AR   NaN         NaN      AR      3                                                   Mitochondria & redox
921       ERN2     AR     AR   AR   NaN         NaN      AR      3                                                                       
1000     FOXA1     AR     AR   AR   NaN          AP      AR      3               Chromatin & epigenetic regulation; Cell-death regulation
1045   GABARAP     AR     AR   AR   NaN         NaN      AR      3                                               Autophagy & proteostasis
2279     PRDX2     AR     AR   AR   NaN         NaN      AR      3                            Mitochondria & redox; Cell-death regulation
2597   RPS6KB2     AP     AP   AP   NaN         NaN      AP      3                                            Growth & nutrient signaling
2725   SLC13A2     AP     AP   AP   NaN         NaN      AP      3                                                                       
2726   SLC13A3     AP     AP   AP   NaN          AP      AP      3                                                                       
2727   SLC13A4     AP     AP   AP   NaN         NaN      AP      3                                                                       
2728   SLC13A5     AP     AP   AP   NaN         NaN      AP      3                                                                       
3287    VPS33A     AR     AR   AR   NaN         NaN      AR      3                                               Autophagy & proteostasis
24       ACAD9    NaN     AP   AP   NaN         NaN      AP      2                                                   Mitochondria & redox
47      ACVR1B    NaN     AP   AP   NaN         NaN      AP      2                                                                       
48      ACVR1C    NaN     AP   AP   NaN         NaN      AP      2                                                  Cell-death regulation
153      AP3S1     AP     AP  NaN   NaN         NaN      AP      2                                            Growth & nutrient signaling
154      AP3S2     AP     AP  NaN   NaN         NaN      AP      2                                                                       
222      ATG2A     AR    NaN   AR   NaN         NaN      AR      2                                               Autophagy & proteostasis
223      ATG2B     AR    NaN   AR   NaN         NaN      AR      2                                               Autophagy & proteostasis
225      ATG4A     AR     AR  NaN   NaN         NaN      AR      2                                               Autophagy & proteostasis
226      ATG4B     AR     AR  NaN   NaN         NaN      AR      2                                               Autophagy & proteostasis
227      ATG4C     AR     AR  NaN   NaN         NaN      AR      2                                               Autophagy & proteostasis
228      ATG4D     AR     AR  NaN   NaN          AR      AR      2                                               Autophagy & proteostasis
230       ATG7     AR  mixed   AR   NaN          AR      AR      2                        Autophagy & proteostasis; Cell-death regulation
231      ATG9A     AR     AR  NaN   NaN         NaN      AR      2                                               Autophagy & proteostasis
232      ATG9B     AR     AR  NaN   NaN         NaN      AR      2                                               Autophagy & proteostasis
265     ATP5PB     AP     AP  NaN   NaN         NaN      AP      2                                                   Mitochondria & redox
268   ATP6V0A1     AP     AP  NaN   NaN         NaN      AP      2                                               Autophagy & proteostasis
269   ATP6V0A2     AP     AP  NaN   NaN          AR      AP      2                                               Autophagy & proteostasis
270   ATP6V0A4     AP     AP  NaN   NaN         NaN      AP      2                                               Autophagy & proteostasis
282    ATP6V1H     AR    NaN   AR   NaN         NaN      AR      2                                                                       
328      BECN1     AR     AR  NaN   NaN          AR      AR      2  Autophagy & proteostasis; Mitochondria & redox; Cell-death regulation
329      BECN2     AR     AR  NaN   NaN         NaN      AR      2                                               Autophagy & proteostasis
352       BRD3     AR     AR  NaN   NaN         NaN      AR      2                                      Chromatin & epigenetic regulation
404        CBS  mixed     AR   AR   NaN          AR      AR      2                                                  Cell-death regulation
462       CDK5     AR    NaN   AR   NaN          AP      AR      2                                                  Cell-death regulation
502      CHMP3     AR     AR  NaN   NaN         NaN      AR      2                                               Autophagy & proteostasis
542       CLTC     AR     AR  NaN   NaN         NaN      AR      2                                                                       
561      CNOT6     AR     AR  NaN   NaN          AR      AR      2                                                                       
562     CNOT6L     AR     AR  NaN   NaN          AR      AR      2                                                                       
C6 Fisher replicated vs single invertebrate -> mouse OR=8.21 p=0.0378
R1 exclusive: maintenance-only n=45 same=33 (0.733); arrest/SASP-only n=41 same=17 (0.415); OR=3.88 p=0.00425
R2 mouse predictions: human genes 180 distinct non-human source-gene groups 112  AP groups 52  AR groups 60  3-organism groups 9
R3 back-test collapsed to families: 13 12
B3 yeast-gene level RLS vs CLS: resolved=402 same=216 share=0.537 p2=0.148
R4 predictions with mouse knockout phenotype: 159; lethal before weaning: 72 (45%)
