AOMIC v1.7 exploratory extensions: all primary values retained.
Complete-case N = 926; focal beta = 0.096835000; OLS p = 0.00905697458; HC3 p = 0.00964582316.
Original primary maximum absolute discrepancy: 1.5543122344752192e-15.

COGNITIVE DOMAIN OUTCOMES (exploratory; HC3 and Holm in CSV):
Cohort          Outcome   N     beta       SE    CI_low  CI_high        p   HC3_SE  HC3_CI_low  HC3_CI_high    HC3_p  df  Holm_within_cohort  HC3_Holm_within_cohort
 AOMIC        IST_fluid 926 0.080936 0.037235  0.007860 0.154012 0.029987 0.038759    0.004869     0.157003 0.037057 918            0.059975                0.074115
 AOMIC       IST_memory 926 0.073194 0.037760 -0.000911 0.147300 0.052878 0.037241    0.000107     0.146282 0.049666 918            0.059975                0.074115
 AOMIC IST_crystallised 926 0.098737 0.036457  0.027187 0.170286 0.006889 0.036553    0.027000     0.170474 0.007036 918            0.020668                0.021109

CEREBELLAR DECOMPOSITION (exploratory; retain null results):
Cohort                          Balance   N     beta       SE    CI_low  CI_high        p   HC3_SE  HC3_CI_low  HC3_CI_high    HC3_p  df  Holm_within_cohort  HC3_Holm_within_cohort
 AOMIC    CerebellarCortex / CerebralWM 926 0.104998 0.037563  0.031279 0.178717 0.005294 0.037900    0.030618     0.179378 0.005712 917            0.018764                0.022846
 AOMIC        CerebellarWM / CerebralWM 926 0.109060 0.044023  0.022663 0.195458 0.013416 0.044547    0.021635     0.196486 0.014543 917            0.026831                0.029085
 AOMIC  CerebellarCortex / CerebellarWM 926 0.019166 0.038729 -0.056841 0.095174 0.620804 0.039541   -0.058436     0.096768 0.627998 917            0.620804                0.627998
 AOMIC LeftCerebellum / RightCerebellum 926 0.090376 0.031885  0.027801 0.152952 0.004691 0.033076    0.025462     0.155290 0.006409 917            0.018764                0.022846

SCALE SENSITIVITIES:
Cohort                       Model   N  baseline_R2  full_R2  added_R2  partial_R2  global_F  global_p  global_HC3_F  global_HC3_p  global_df1  global_df2     beta       SE    CI_low  CI_high        p   HC3_SE  HC3_CI_low  HC3_CI_high    HC3_p  df
 AOMIC       Primary tissue volume 926     0.066605 0.079221  0.012616    0.013516  3.144477  0.013959      3.026376      0.017060           4         918 0.096835 0.037024  0.024173 0.169497 0.009057 0.037335    0.023564     0.170106 0.009646 918
 AOMIC eTIV replaces tissue volume 926     0.043468 0.052179  0.008711    0.009107  2.109154  0.077750      2.177522      0.069659           4         918 0.016540 0.034425 -0.051021 0.084101 0.631016 0.036208   -0.054520     0.087599 0.647920 918
 AOMIC     Tissue volume plus eTIV 926     0.066616 0.079285  0.012668    0.013573  3.154323  0.013727      3.090109      0.015312           4         917 0.098145 0.037405  0.024736 0.171555 0.008838 0.036968    0.025593     0.170698 0.008072 917

CAUTIONS:
The two alternative size models condition on different quantities; persistence with both covariates is not proof that the eTIV-only model is invalid.
eTIV is an atlas-scaling estimate; no causal attribution to eTIV noise or suppression can be inferred from these regressions.
T/eTIV is the fraction occupied by the selected five compartments. Do not equate it without qualification to global parenchymal fraction.
Separate standardized cortex/cerebral-WM and cerebellar-WM/cerebral-WM coefficients have different scale factors. Compare the direct cortex/cerebellar-WM contrast rather than infer a difference from magnitudes.
All new follow-up analyses were added after the AOMIC primary result was observed; the primary replication status is unchanged.
FWL residuals control age, sex, logT and all three remaining ILR coordinates; scatter slope equals the published standardized focal beta.
Private residual CSV is not to be distributed.
