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["Table S44 The common (1-14) and specific enriched pathways (15-91) for BRCA and MBCA using ReactomeFIVIz (FDR < 0.03). Also, this table shows the number and names of the top 100 genes in a given enriched pathway for both of BRCA and MBCA"]
["Number ","Pathways","Genes for BRCA","Number of genes in \neach pathway for BRCA","Genes for MBCA","Number of genes in each \npathway for MBCA"]
[1,"RUNX1 regulates estrogen receptor mediated transcription","RUNX1,CBFB,SMARCA4",3,"RUNX1,CBFB",2]
[2,"RUNX2 regulates bone development","RUNX1,CBFB",2,"AR,CBFB,HDAC3",3]
[3,"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes","RUNX1,CBFB",2,"RUNX1,CBFB",2]
[4,"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known","RUNX1,CBFB",2,"RUNX1,CBFB",2]
[5,"Generic Transcription Pathway","RUNX1,CBFB",2,"RUNX1,AR,TBL1XR1,CBFB,BDNF,YWHAE,SIN3A,PRMT1,NCOR1,HDAC3,GPS2,STAT1,KLF4,KRAS",14]
[6,"RUNX3 regulates p14-ARF","RUNX1,CBFB",2,"RUNX1,CBFB,KRAS",3]
[7,"Signaling by Receptor Tyrosine Kinases","RUNX1,CBFB",2,"KDR,PRKCD,COL4A3,PIK3R1,PDGFD,BDNF,PTPRJ,NCOR1,NOS3,STAT1,KRAS",11]
[8,"RUNX2 regulates genes involved in differentiation of myeloid cells","NBN,RUNX1,CBFB,NOTCH4,ABL1,SMAD2,SMAD4,SMURF1,SMARCA4,NR4A1,PTEN,MED23,TFDP1,PPARG,PTPN11",15,"RUNX1,CBFB",2]
[9,"RUNX1 regulates expression of components of tight junctions","RUNX1,CBFB",2,"RUNX1,CBFB",2]
[10,"RUNX1 regulates transcription of genes involved in interleukin signaling","RUNX1,CBFB",2,"RUNX1,CBFB",2]
[11,"RUNX1 regulates transcription of genes involved in BCR signaling","GRB7,PRKCZ,FLT1,ITGB3,ITGAV,GAB1,GAB2,ERBB3,EGF,PTPN11",10,"RUNX1,CBFB",2]
[12,"RUNX1 regulates transcription of genes involved in WNT signaling","CBFB,ABL1,SMAD4",3,"RUNX1,CBFB",2]
[13,"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells","RUNX1,CBFB",2,"RUNX1,CBFB",2]
[14,"Transcriptional regulation by RUNX2","RUNX1,CBFB,ABL1,SMAD4,SMURF1",5,"RUNX1,AR,CBFB,HDAC3,STAT1",5]
[15,"Signaling by TGF-beta Receptor Complex","PARD3,PRKCZ,SMAD2,SMAD4,SMURF1,TGFBR2,TFDP1",7,"None",0]
[16,"PECAM1 interactions","ITGB3,ITGAV,PTPN11",3,"None",0]
[17,"Interleukin-15 signaling","JAK1,GAB2,IL2RB",3,"None",0]
[18,"RET signaling","GRB7,GAB1,GAB2,PTPN11",4,"None",0]
[19,"PI3K events in ERBB2 signaling","GAB1,ERBB3,EGF",3,"None",0]
[20,"Signaling by ERBB2","GRB7,GAB1,ERBB3,EGF",4,"None",0]
[21,"Signaling by NODAL","SMAD2,SMAD4,ACVR1B",3,"None",0]
[22,"Reelin signalling pathway","VLDLR,RELN",2,"None",0]
[23,"Negative regulation of the PI3K/AKT network","PTEN,GAB1,ERBB3,EGF,PTPN11",5,"None",0]
[24,"Integrin cell surface interactions","ICAM1,FN1,ITGAM,ITGB5,ITGB3,ITGAV,ITGA4",7,"None",0]
[25,"Signaling by TGF-beta family members","PARD3,PRKCZ,SMAD2,SMAD4,SMURF1,TGFBR2,TFDP1,ACVR1B",8,"None",0]
[26,"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)","PARD3,PRKCZ,SMURF1,TGFBR2",4,"None",0]
[27,"Signaling by Interleukins","IL1RN,ICAM1,POU2F1,FN1,MSN,SMARCA4,ITGAM,JAK1,SYK,GAB2,IL1RAPL1,PTPN11,IL2RB",13,"None",0]
[28,"RNA Polymerase II Transcription","NBN,RUNX1,CBFB,NOTCH4,ABL1,SMAD2,SMAD4,POU2F1,CPSF1,SMURF1,CPSF3,SMARCA4,NR4A1,PTEN,PCF11,MED23,TFDP1,PPARG,PTPN11",19,"None",0]
[29,"Interleukin-2 signaling","JAK1,SYK,IL2RB",3,"None",0]
[30,"GPVI-mediated activation cascade","PRKCZ,PIK3CG,SYK,PTPN11",4,"None",0]
[31,"TGF-beta receptor signaling activates SMADs","SMAD2,SMAD4,SMURF1,TGFBR2",4,"None",0]
[32,"Signaling by Activin","SMAD2,SMAD4,ACVR1B",3,"None",0]
[33,"Regulation of RUNX1 Expression and Activity","RUNX1,CBFB,PTPN11",3,"None",0]
[34,"Interleukin-3, Interleukin-5 and GM-CSF signaling","JAK1,GAB2,PTPN11,IL2RB",4,"None",0]
[35,"Interleukin-2 family signaling","JAK1,SYK,GAB2,IL2RB",4,"None",0]
[36,"GAB1 signalosome","GAB1,EGF,PTPN11",3,"None",0]
[37,"Platelet activation, signaling and aggregation","PRKCZ,FN1,SERPINA1,ITGB3,PIK3CG,SYK,EGF,PTPN11",8,"None",0]
[38,"Syndecan interactions","ITGB5,ITGB3,ITGAV",3,"None",0]
[39,"Processing of Intronless Pre-mRNAs","CPSF1,CPSF3,PCF11",3,"None",0]
[40,"ECM proteoglycans","ITGB5,ITGB3,ITGAV,DCN",4,"None",0]
[41,"GRB7 events in ERBB2 signaling","GRB7,ERBB3",2,"None",0]
[42,"MET activates PTPN11","GAB1,PTPN11",2,"None",0]
[43,"Interleukin receptor SHC signaling","JAK1,GAB2,IL2RB",3,"None",0]
[44,"Downregulation of TGF-beta receptor signaling","SMAD2,SMURF1,TGFBR2",3,"None",0]
[45,"Integrin alphaIIb beta3 signaling","FN1,ITGB3,SYK",3,"None",0]
[46,"Integrin signaling","FN1,ITGB3,SYK",3,"None",0]
[47,"Processing of Capped Intronless Pre-mRNA","CPSF1,CPSF3,PCF11",3,"None",0]
[48,"Molecules associated with elastic fibres","ITGB5,ITGB3,ITGAV",3,"None",0]
[49,"Cell surface interactions at the vascular wall","GRB7,FN1,ITGAM,ITGB3,ITGAV,ITGA4,PTPN11",7,"None",0]
[50,"Cross-presentation of particulate exogenous antigens (phagosomes)","ITGB5,ITGAV",2,"None",0]
[51,"MAPK1 (ERK2) activation","JAK1,PTPN11",2,"None",0]
[52,"Interleukin-4 and Interleukin-13 signaling","ICAM1,POU2F1,FN1,ITGAM,JAK1",5,"None",0]
[53,"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription","SMAD2,SMAD4,TFDP1",3,"None",0]
[54,"MAPK3 (ERK1) activation","JAK1,PTPN11",2,"None",0]
[55,"Cytokine Signaling in Immune system","IL1RN,ICAM1,POU2F1,FN1,MSN,SMARCA4,ITGAM,JAK1,SYK,GAB2,IL1RAPL1,PTPN11,IL2RB",13,"None",0]
[56,"PIP3 activates AKT signaling","NR4A1,PTEN,GAB1,PPARG,ERBB3,EGF,PTPN11",7,"None",0]
[57,"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)","RUNX1,CBFB",2,"None",0]
[58,"Interleukin-6 signaling","JAK1,PTPN11",2,"None",0]
[59,"Pre-NOTCH Transcription and Translation","RUNX1,NOTCH4,TFDP1",3,"None",0]
[60,"Elastic fibre formation","ITGB5,ITGB3,ITGAV",3,"None",0]
[61,"mRNA Splicing - Major Pathway","CPSF1,CPSF3,PCF11,PRPF40A,SF3B1,SF3A1",6,"None",0]
[62,"Platelet Aggregation (Plug Formation)","FN1,ITGB3,SYK",3,"None",0]
[63,"Non-integrin membrane-ECM interactions","ITGB5,ITGB3,ITGAV",3,"None",0]
[64,"Regulation of MECP2 expression and activity","None",0,"TBL1XR1,SIN3A,NCOR1,HDAC3,GPS2",5]
[65,"Transcriptional Regulation by MECP2","None",0,"TBL1XR1,BDNF,SIN3A,NCOR1,HDAC3,GPS2",6]
[66,"Signaling by PDGF","None",0,"COL4A3,PIK3R1,PDGFD,STAT1,KRAS",5]
[67,"HDACs deacetylate histones","None",0,"TBL1XR1,NCOR1,HDAC3,GPS2",4]
[68,"ESR-mediated signaling","None",0,"FOXA1,KPNA2,RUNX1,CBFB,STAG1,PRMT1",6]
[69,"NR1D1 (REV-ERBA) represses gene expression","None",0,"NCOR1,HDAC3",2]
[70,"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function","None",0,"RUNX1,CBFB,SIN3A,PRMT1",4]
[71,"VEGFR2 mediated cell proliferation","None",0,"KDR,PRKCD,KRAS",3]
[72,"VEGFA-VEGFR2 Pathway","None",0,"KDR,PRKCD,PIK3R1,NOS3,KRAS",5]
[73,"Transcriptional activation of mitochondrial biogenesis","None",0,"TBL1XR1,SIRT4,NCOR1,HDAC3",4]
[74,"PLC beta mediated events","None",0,"KPNA2,PRKCG,PRKCD,PLCB1",4]
[75,"Signaling by Nuclear Receptors","None",0,"FOXA1,KPNA2,RUNX1,CBFB,STAG1,PRMT1",6]
[76,"G-protein mediated events","None",0,"KPNA2,PRKCG,PRKCD,PLCB1",4]
[77,"RUNX2 regulates osteoblast differentiation","None",0,"AR,CBFB,HDAC3",3]
[78,"Signaling by VEGF","None",0,"KDR,PRKCD,PIK3R1,NOS3,KRAS",5]
[79,"Signaling by NTRK2 (TRKB)","None",0,"PIK3R1,BDNF,KRAS",3]
[80,"Chromatin modifying enzymes","None",0,"ACTB,TBL1XR1,KDM6B,PRMT1,NCOR1,HDAC3,GPS2",7]
[81,"Downstream signal transduction","None",0,"PIK3R1,STAT1,KRAS",3]
[82,"Transmission across Chemical Synapses","None",0,"ABAT,KPNA2,PRKCG,CACNA1E,PLCB1,GRIN1,KRAS",7]
[83,"Opioid Signalling","None",0,"KPNA2,PRKCG,PRKCD,PLCB1",4]
[84,"CaM pathway","None",0,"KPNA2,PRKCG,PRKCD",3]
[85,"Calmodulin induced events","None",0,"KPNA2,PRKCG,PRKCD",3]
[86,"Activated NTRK2 signals through RAS","None",0,"BDNF,KRAS",2]
[87,"Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)","None",0,"TBL1XR1,SIN3A,NCOR1,HDAC3,GPS2",5]
[88,"Estrogen-dependent gene expression","None",0,"FOXA1,KPNA2,RUNX1,CBFB,STAG1,PRMT1",6]
[89,"Activated NTRK2 signals through PI3K","None",0,"PIK3R1,BDNF",2]
[90,"MECP2 regulates transcription of neuronal ligands","None",0,"BDNF,SIN3A",2]
[91,"RHO GTPase Effectors","None",0,"BUB1B,ACTB,PRKCD,",7]
[{"$nulls":4},"AR,YWHAE,WAS,PKN2"]