AD Research Square direct-submission package — 2026-09-10
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Built by fix_ad_rs.py + make_esm.py from Grok's AD_RS_direct_preprint_20260909
and the bioRxiv-era AD supplement. Alzheimer's disease preprint only; no
companion cross-references remain in any file.

Upload
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AD_manuscript_RS_20260910.docx                main text (66 references; Tables 1-6;
                                              Fig. 1-2 legends; headed declarations)
AD_Figure_1.tiff                              300 dpi, 2966x1261 (re-rendered; no
                                              "companion" wording on the artwork)
AD_Figure_2.tiff                              300 dpi, 2966x1122 (unchanged)
ESM_1_AD_supplementary_materials_20260910.docx  supplementary methods, Table S1,
                                              robustness checks, Notes S1-S4
ESM_2_Table_S2_468_gene_panel.xlsx            locked panel (sheets S2, S2b, S2c)
ESM_3_Table_S3_AD_meta_analysis.xlsx          per-gene meta-analysis, 458 genes /
                                              167 FDR / 141 HC, from meta_AD.csv

Not for upload: AD_RS_grok_20260909.docx (Grok source), AD_Figure_1_grok.tiff,
ESM_1_AD_notes.pdf (folded into the supplement as Notes S1-S4),
ESM_2_Table_S0_468_gene_panel.xlsx (superseded by ESM_2_Table_S2), the .py
scripts and the PDF renders.

Research Square form fields (from the manuscript)
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Ethics: the ETHICS AND HUMAN SUBJECTS paragraph verbatim (AMSBIO tissue;
  N. N. Blokhin Russian Oncological Research Center PG-ONC 2003/1).
Competing interests: the COMPETING INTERESTS paragraph verbatim.
Funding / Author contributions / Data availability: the headed paragraphs.
Abstract: plain-ASCII copy recommended (log2FC, "greater than or equal to",
  hyphens); the docx abstract still carries Unicode.
Hepatic RNA-seq GEO accession: pending; add at first revision.
