source protein1 protein2 chain position wt mut feat mut_cat ddg plddt conf AlphaFold O14929 P62805 A 64 E A mutation decreasing rate(MI:1130) Impact 0.78775 90.76 Very high (pLDDT > 90) AlphaFold O14929 P62805 A 62 D A mutation decreasing rate(MI:1130) Impact 1.298508 83.68 Confident (90 > pLDDT > 70) AlphaFold O14929 P62805 A 187 E Q mutation decreasing rate(MI:1130) Impact 0.38563 83.24 Confident (90 > pLDDT > 70) AlphaFold O14929 P62805 A 277 D N mutation decreasing rate(MI:1130) Impact 0.32092 89.08 Confident (90 > pLDDT > 70) AlphaFold O14929 P62805 A 276 E Q mutation decreasing rate(MI:1130) Impact 0.06681 92.26 Very high (pLDDT > 90) AlphaFold O43257 Q9GZN1 A 103 T A mutation disrupting(MI:0573) Impact 0.041 93.27 Very high (pLDDT > 90) AlphaFold O43482 Q9NYP9 A 179 I K mutation with no effect(MI:2226) Neutral 0.8731 93.27 Very high (pLDDT > 90) AlphaFold O43482 Q9NYP9 A 61 A P mutation with no effect(MI:2226) Neutral -0.019 38.74 Very low (pLDDT < 50) AlphaFold O60216 Q8N3U4 A 327 D K mutation decreasing strength(MI:1133) Impact 1.9464 81.17 Confident (90 > pLDDT > 70) AlphaFold O60828 Q9Y2W2 A 64 Y A mutation disrupting(MI:0573) Impact 1.1396 92.99 Very high (pLDDT > 90) AlphaFold O60828 Q9Y2W2 A 65 Y C mutation disrupting(MI:0573) Impact 0.3269 93.89 Very high (pLDDT > 90) AlphaFold O60828 Q9Y2W2 A 75 W A mutation disrupting(MI:0573) Impact 3.1991 93.4 Very high (pLDDT > 90) AlphaFold O60828 Q9Y2W2 A 73 V A mutation decreasing(MI:0119) Impact 1.3328 94.09 Very high (pLDDT > 90) AlphaFold O60828 Q9Y2W2 A 66 W A mutation disrupting(MI:0573) Impact 3.5219 94.19 Very high (pLDDT > 90) AlphaFold O75771 O43543 A 34 A V mutation with no effect(MI:2226) Neutral 0.0575 91.63 Very high (pLDDT > 90) AlphaFold O75771 O43543 A 34 A V mutation decreasing strength(MI:1133) Impact 0.0575 91.63 Very high (pLDDT > 90) AlphaFold O75771 O43543 A 233 E G mutation with no effect(MI:2226) Neutral 0.2447 92.6 Very high (pLDDT > 90) AlphaFold O75771 O43543 A 233 E G mutation with no effect(MI:2226) Neutral 0.2447 92.6 Very high (pLDDT > 90) AlphaFold O75771 O43543 A 233 E G mutation with no effect(MI:2226) Neutral 0.2447 92.6 Very high (pLDDT > 90) AlphaFold O95931 Q99496 A 234 F D mutation disrupting(MI:0573) Impact 4.2748 92.46 Very high (pLDDT > 90) AlphaFold P00492 Q9NRG1 A 38 P S mutation with no effect(MI:2226) Neutral -0.7477 98.57 Very high (pLDDT > 90) AlphaFold P01100 P05412 A 123 I V mutation disrupting strength(MI:1128) Impact 0 57.92 Low (70 > pLDDT > 50) AlphaFold P01100 P05412 A 176 K N mutation disrupting strength(MI:1128) Impact 1.1075 98.53 Very high (pLDDT > 90) AlphaFold P02511 P04792 A 120 R G mutation(MI:0118) Neutral -0.5936 82.61 Confident (90 > pLDDT > 70) AlphaFold P06730 Q13541 A 49 K R mutation increasing(MI:0382) Impact -0.6719 95.21 Very high (pLDDT > 90) AlphaFold P06730 Q13541 A 162 K R mutation increasing(MI:0382) Impact 0 97.51 Very high (pLDDT > 90) AlphaFold P06730 Q13541 A 36 K R mutation increasing(MI:0382) Impact -0.0512 91.91 Very high (pLDDT > 90) AlphaFold P06730 Q13541 A 206 K R mutation increasing(MI:0382) Impact 0.0086 76.5 Confident (90 > pLDDT > 70) AlphaFold P07195 P00338 A 172 R P mutation with no effect(MI:2226) Neutral -0.4781 96.16 Very high (pLDDT > 90) AlphaFold P07195 P00338 A 7 K E mutation with no effect(MI:2226) Neutral 0.0657 95.08 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 194 F S mutation disrupting strength(MI:1128) Impact -0.202 94.99 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 194 F S mutation disrupting(MI:0573) Impact -0.202 94.99 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 194 F S mutation with no effect(MI:2226) Neutral -0.202 94.99 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 194 F S mutation disrupting strength(MI:1128) Impact -0.202 94.99 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 233 F I mutation with no effect(MI:2226) Neutral -0.0125 96.5 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 233 F I mutation with no effect(MI:2226) Neutral -0.0125 96.5 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 213 N K mutation with no effect(MI:2226) Neutral 0.2516 95.73 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 213 N K mutation with no effect(MI:2226) Neutral 0.2516 95.73 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 213 N K mutation with no effect(MI:2226) Neutral 0.2516 95.73 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 260 G R mutation with no effect(MI:2226) Neutral -0.0079 97.48 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 260 G R mutation disrupting strength(MI:1128) Impact -0.0079 97.48 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 260 G R mutation disrupting strength(MI:1128) Impact -0.0079 97.48 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 260 G R mutation disrupting strength(MI:1128) Impact -0.0079 97.48 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 260 G R mutation disrupting(MI:0573) Impact -0.0079 97.48 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 218 R K mutation with no effect(MI:2226) Neutral 0.6679 92.37 Very high (pLDDT > 90) AlphaFold P09467 O00757 A 218 R K mutation with no effect(MI:2226) Neutral 0.6679 92.37 Very high (pLDDT > 90) AlphaFold P11940 Q9H074 A 580 K A mutation disrupting(MI:0573) Impact 0.4858 93.29 Very high (pLDDT > 90) AlphaFold P11940 Q9H074 A 567 F A mutation disrupting(MI:0573) Impact 2.7132 93.59 Very high (pLDDT > 90) AlphaFold P13010 Q8IW19 A 68 L R mutation disrupting(MI:0573) Impact 0.1215 89.13 Confident (90 > pLDDT > 70) AlphaFold P13010 Q8IW19 A 74 Y R mutation disrupting(MI:0573) Impact -0.4252 90.23 Very high (pLDDT > 90) AlphaFold P13010 Q8IW19 A 112 I R mutation disrupting(MI:0573) Impact 6.7878 94.55 Very high (pLDDT > 90) AlphaFold P17612 P10644 A 206 L R mutation disrupting strength(MI:1128) Impact 0.0879 95.07 Very high (pLDDT > 90) AlphaFold P17612 P10644 A 206 L R mutation disrupting strength(MI:1128) Impact 0.0879 95.07 Very high (pLDDT > 90) AlphaFold P17612 P10644 A 206 L R mutation disrupting strength(MI:1128) Impact 0.0879 95.07 Very high (pLDDT > 90) AlphaFold P17612 P31323 A 206 L R mutation decreasing strength(MI:1133) Impact 0.4476 95.65 Very high (pLDDT > 90) AlphaFold P17612 P31323 A 206 L R mutation disrupting strength(MI:1128) Impact 0.4476 95.65 Very high (pLDDT > 90) AlphaFold P17612 P31323 A 206 L R mutation decreasing strength(MI:1133) Impact 0.4476 95.65 Very high (pLDDT > 90) AlphaFold P17612 P31323 A 206 L R mutation decreasing strength(MI:1133) Impact 0.4476 95.65 Very high (pLDDT > 90) AlphaFold P21266 Q03013 A 86 R H mutation disrupting strength(MI:1128) Impact 2.6183 97.25 Very high (pLDDT > 90) AlphaFold P23526 Q9BV19 A 86 D G mutation disrupting strength(MI:1128) Impact -0.0593 95.47 Very high (pLDDT > 90) AlphaFold P23526 Q9BV19 A 86 D G mutation with no effect(MI:2226) Neutral -0.0593 95.47 Very high (pLDDT > 90) AlphaFold P23526 Q9BV19 A 86 D G mutation disrupting strength(MI:1128) Impact -0.0593 95.47 Very high (pLDDT > 90) AlphaFold P23526 Q9BV19 A 143 Y C mutation with no effect(MI:2226) Neutral -0.1082 97.36 Very high (pLDDT > 90) AlphaFold P23526 Q9BV19 A 143 Y C mutation with no effect(MI:2226) Neutral -0.1082 97.36 Very high (pLDDT > 90) AlphaFold P23526 Q9BV19 A 143 Y C mutation with no effect(MI:2226) Neutral -0.1082 97.36 Very high (pLDDT > 90) AlphaFold P23526 Q9BV19 A 89 A V mutation with no effect(MI:2226) Neutral 0.0482 98.08 Very high (pLDDT > 90) AlphaFold P23526 Q9BV19 A 89 A V mutation with no effect(MI:2226) Neutral 0.0482 98.08 Very high (pLDDT > 90) AlphaFold P23526 Q9BV19 A 89 A V mutation with no effect(MI:2226) Neutral 0.0482 98.08 Very high (pLDDT > 90) AlphaFold P34932 P11142 A 622 E A mutation decreasing(MI:0119) Impact 1.0308 94 Very high (pLDDT > 90) AlphaFold P34932 P11142 A 619 N Y mutation decreasing(MI:0119) Impact -2.7434 91.85 Very high (pLDDT > 90) AlphaFold P35226 P78364 A 178 F D mutation decreasing strength(MI:1133) Impact 3.8737 95.59 Very high (pLDDT > 90) AlphaFold P35226 P78364 A 163 Y A mutation decreasing strength(MI:1133) Impact 2.0467 94.77 Very high (pLDDT > 90) AlphaFold P35226 P78364 A 165 R A mutation decreasing strength(MI:1133) Impact 1.8801 94.01 Very high (pLDDT > 90) AlphaFold P48729 A6ND36 A 141 N A mutation with no effect(MI:2226) Neutral 0.14473 96.64 Very high (pLDDT > 90) AlphaFold P50213 P51553 A 115 R Q mutation decreasing(MI:0119) Impact 0.2374 88.56 Confident (90 > pLDDT > 70) AlphaFold P50616 Q9UIV1 A 50 Y N mutation with no effect(MI:2226) Neutral -0.05664 83.22 Confident (90 > pLDDT > 70) AlphaFold P50750 O60563 A 175 S D mutation with no effect(MI:2226) Neutral 0.9333 72.82 Confident (90 > pLDDT > 70) AlphaFold P50750 O60563 A 175 S A mutation with no effect(MI:2226) Neutral -0.1308 72.82 Confident (90 > pLDDT > 70) AlphaFold P55072 Q9UNZ2 A 113 R A mutation decreasing strength(MI:1133) Impact 0.2277 87.2 Confident (90 > pLDDT > 70) AlphaFold P55072 Q9UNZ2 A 131 F A mutation decreasing strength(MI:1133) Impact 1.7055 80.65 Confident (90 > pLDDT > 70) AlphaFold P55072 Q9UNZ2 A 183 H A mutation decreasing strength(MI:1133) Impact 0.1948 84.92 Confident (90 > pLDDT > 70) AlphaFold P60510 Q9NY27 A 277 E K mutation decreasing(MI:0119) Impact 0.00307 92.78 Very high (pLDDT > 90) AlphaFold P60510 Q9NY27 A 107 R E mutation disrupting(MI:0573) Impact -0.77389 96.36 Very high (pLDDT > 90) AlphaFold P60510 Q9NY27 A 76 N D mutation disrupting(MI:0573) Impact -0.22274 97.98 Very high (pLDDT > 90) AlphaFold P60891 P11908 A 43 E D mutation disrupting strength(MI:1128) Impact 0.6547 92.13 Very high (pLDDT > 90) AlphaFold P60891 Q14558 A 43 E D mutation with no effect(MI:2226) Neutral 1.5712 92.36 Very high (pLDDT > 90) AlphaFold P60891 Q14558 A 114 N S mutation with no effect(MI:2226) Neutral -0.2369 97.41 Very high (pLDDT > 90) AlphaFold P60891 Q14558 A 114 N S mutation with no effect(MI:2226) Neutral -0.2369 97.41 Very high (pLDDT > 90) AlphaFold P61006 Q92930 A 72 T A mutation(MI:0118) Neutral -0.38282 56.25 Low (70 > pLDDT > 50) AlphaFold P61026 P31150 A 73 T E mutation(MI:0118) Neutral -0.39649 48.86 Very low (pLDDT < 50) AlphaFold P61026 P31150 A 73 T A mutation with no effect(MI:2226) Neutral -0.45431 48.86 Very low (pLDDT < 50) AlphaFold P61026 P31150 A 73 T A mutation increasing strength(MI:1132) Impact -0.45431 48.86 Very low (pLDDT < 50) AlphaFold P61026 P31150 A 73 T E mutation disrupting strength(MI:1128) Impact -0.39649 48.86 Very low (pLDDT < 50) AlphaFold P61081 Q15843 A 116 R A mutation decreasing rate(MI:1130) Impact -0.07176 91.16 Very high (pLDDT > 90) AlphaFold P61081 Q15843 A 113 N A mutation disrupting strength(MI:1128) Impact -0.37354 89.78 Confident (90 > pLDDT > 70) AlphaFold P61326 P38919 A 20 E R mutation disrupting(MI:0573) Impact -0.2527936 80.71 Confident (90 > pLDDT > 70) AlphaFold P61326 Q9BRP8 A 117 E R mutation decreasing(MI:0119) Impact -0.3629 91.57 Very high (pLDDT > 90) AlphaFold P61326 Q9BRP8 A 117 E R mutation disrupting(MI:0573) Impact -0.3629 91.57 Very high (pLDDT > 90) AlphaFold P61326 Q9BRP8 A 68 E R mutation disrupting(MI:0573) Impact 1.1355 93.66 Very high (pLDDT > 90) AlphaFold P61326 Q9BRP8 A 68 E R mutation decreasing(MI:0119) Impact 1.1355 93.66 Very high (pLDDT > 90) AlphaFold P61326 Q9Y5S9 A 136 L R mutation decreasing(MI:0119) Impact 3.5195 98.18 Very high (pLDDT > 90) AlphaFold P61326 Q9Y5S9 A 117 E R mutation decreasing(MI:0119) Impact 0.2084 97.46 Very high (pLDDT > 90) AlphaFold P61326 Q9Y5S9 A 68 E R mutation decreasing(MI:0119) Impact 0.5213 96.83 Very high (pLDDT > 90) AlphaFold P61764 O75558 A 84 V D mutation disrupting strength(MI:1128) Impact -0.1545 96.26 Very high (pLDDT > 90) AlphaFold P61764 O75558 A 84 V D mutation disrupting strength(MI:1128) Impact -0.1545 96.26 Very high (pLDDT > 90) AlphaFold P62195 P43686 A 258 R W mutation with no effect(MI:2226) Neutral -0.3428 59.54 Low (70 > pLDDT > 50) AlphaFold P62805 P84243 A 73 Y A mutation disrupting strength(MI:1128) Impact 0.0168 94.75 Very high (pLDDT > 90) AlphaFold P62993 Q07889 A 33 D A mutation decreasing(MI:0119) Impact -0.1903992 61.63 Low (70 > pLDDT > 50) AlphaFold P62993 Q07889 A 31 E A mutation decreasing(MI:0119) Impact -0.2143713 59.98 Low (70 > pLDDT > 50) AlphaFold P63279 Q9UBT2 A 131 A D mutation decreasing rate(MI:1130) Impact 0.3365 69.59 Low (70 > pLDDT > 50) AlphaFold P63279 Q9UBT2 A 130 Q A mutation decreasing rate(MI:1130) Impact 0.0549 75.61 Confident (90 > pLDDT > 70) AlphaFold P63279 Q9UBT2 A 138 C A mutation with no effect(MI:2226) Neutral -0.0647 84.06 Confident (90 > pLDDT > 70) AlphaFold P63279 Q9UBT2 A 134 Y A mutation decreasing rate(MI:1130) Impact 0.2302 81.96 Confident (90 > pLDDT > 70) AlphaFold P63279 Q9UBT2 A 93 C A mutation with no effect(MI:2226) Neutral 0.225 85.28 Confident (90 > pLDDT > 70) AlphaFold P63279 Q9UBT2 A 132 E A mutation decreasing rate(MI:1130) Impact -1.1927 73.33 Confident (90 > pLDDT > 70) AlphaFold P67775 P30153 A 309 L A mutation with no effect(MI:2226) Neutral 1.292744 33.12 Very low (pLDDT < 50) AlphaFold P67775 P30153 A 309 L A mutation with no effect(MI:2226) Neutral 1.292744 33.12 Very low (pLDDT < 50) AlphaFold P67775 P30153 A 309 L A mutation with no effect(MI:2226) Neutral 1.292744 33.12 Very low (pLDDT < 50) AlphaFold P84022 O95405 A 239 E K mutation with no effect(MI:2226) Neutral 0.036 95.85 Very high (pLDDT > 90) AlphaFold P84022 O95405 A 239 E K mutation with no effect(MI:2226) Neutral 0.036 95.85 Very high (pLDDT > 90) AlphaFold P84022 O95405 A 330 T A mutation with no effect(MI:2226) Neutral -0.0457 92.51 Very high (pLDDT > 90) AlphaFold P84022 O95405 A 330 T A mutation with no effect(MI:2226) Neutral -0.0457 92.51 Very high (pLDDT > 90) AlphaFold Q02750 P15056 A 314 L E mutation disrupting strength(MI:1128) Impact 3.8911 83.36 Confident (90 > pLDDT > 70) AlphaFold Q02750 P15056 A 314 L E mutation disrupting rate(MI:1129) Impact 3.8911 83.36 Confident (90 > pLDDT > 70) AlphaFold Q02750 P15056 A 310 I E mutation decreasing rate(MI:1130) Impact 2.0621 72.05 Confident (90 > pLDDT > 70) AlphaFold Q02750 P15056 A 310 I E mutation decreasing strength(MI:1133) Impact 2.0621 72.05 Confident (90 > pLDDT > 70) AlphaFold Q02750 P15056 A 228 S E mutation decreasing strength(MI:1133) Impact 0.3001 79.26 Confident (90 > pLDDT > 70) AlphaFold Q02750 P15056 A 228 S E mutation decreasing rate(MI:1130) Impact 0.3001 79.26 Confident (90 > pLDDT > 70) AlphaFold Q03518 Q03519 A 441 A C mutation(MI:0118) Neutral 0.329 84.26 Confident (90 > pLDDT > 70) AlphaFold Q12824 Q6STE5 A 366 R C mutation(MI:0118) Neutral -0.07247 78.75 Confident (90 > pLDDT > 70) AlphaFold Q12824 Q8TAQ2 A 366 R C mutation(MI:0118) Neutral 0.0517 80.73 Confident (90 > pLDDT > 70) AlphaFold Q12824 Q8TAQ2 A 377 R C mutation(MI:0118) Neutral 0.0054 67.49 Low (70 > pLDDT > 50) AlphaFold Q12824 Q8TAQ2 A 377 R C mutation(MI:0118) Neutral 0.0054 67.49 Low (70 > pLDDT > 50) AlphaFold Q12824 Q92784 A 377 R C mutation(MI:0118) Neutral 2.68295 58.51 Low (70 > pLDDT > 50) AlphaFold Q12824 Q92784 A 363 K N mutation with no effect(MI:2226) Neutral -0.04063 81.14 Confident (90 > pLDDT > 70) AlphaFold Q12824 Q92784 A 366 R C mutation(MI:0118) Neutral 0.36661 74.95 Confident (90 > pLDDT > 70) AlphaFold Q12824 Q92922 A 377 R C mutation(MI:0118) Neutral -0.0208 68.28 Low (70 > pLDDT > 50) AlphaFold Q12824 Q92922 A 377 R C mutation(MI:0118) Neutral -0.0208 68.28 Low (70 > pLDDT > 50) AlphaFold Q12824 Q96GM5 A 377 R C mutation(MI:0118) Neutral -0.043841 61.24 Low (70 > pLDDT > 50) AlphaFold Q12824 Q96GM5 A 377 R C mutation(MI:0118) Neutral -0.043841 61.24 Low (70 > pLDDT > 50) AlphaFold Q13418 P48059 A 223 K N mutation with no effect(MI:2226) Neutral 0.090044 85.67 Confident (90 > pLDDT > 70) AlphaFold Q13418 P48059 A 349 R H mutation with no effect(MI:2226) Neutral -0.0294 65.24 Low (70 > pLDDT > 50) AlphaFold Q13418 P48059 A 278 Y H mutation with no effect(MI:2226) Neutral 0.042683 93.12 Very high (pLDDT > 90) AlphaFold Q13418 Q9NVD7 A 223 K N mutation disrupting strength(MI:1128) Impact 0.2583 82.8 Confident (90 > pLDDT > 70) AlphaFold Q13418 Q9NVD7 A 349 R H mutation disrupting strength(MI:1128) Impact 3.0546 82.56 Confident (90 > pLDDT > 70) AlphaFold Q13418 Q9NVD7 A 362 Q H mutation with no effect(MI:2226) Neutral -0.5784 91.68 Very high (pLDDT > 90) AlphaFold Q13637 P57729 A 85 Q L mutation(MI:0118) Neutral 0 69.01 Low (70 > pLDDT > 50) AlphaFold Q13637 P57729 A 85 Q L mutation(MI:0118) Neutral 0 69.01 Low (70 > pLDDT > 50) AlphaFold Q15006 Q8N4V1 A 156 E A mutation disrupting strength(MI:1128) Impact 0.3582 94.47 Very high (pLDDT > 90) AlphaFold Q15006 Q8N4V1 A 227 R A mutation disrupting strength(MI:1128) Impact 0.6463 93.7 Very high (pLDDT > 90) AlphaFold Q15006 Q8N4V1 A 160 E A mutation disrupting strength(MI:1128) Impact 1.8454 96.66 Very high (pLDDT > 90) AlphaFold Q15006 Q8N4V1 A 28 R A mutation disrupting strength(MI:1128) Impact -1.4672 88.7 Confident (90 > pLDDT > 70) AlphaFold Q15437 P53992 A 426 V I mutation with no effect(MI:2226) Neutral 0 93.71 Very high (pLDDT > 90) AlphaFold Q15459 Q12874 A 169 L K mutation disrupting(MI:0573) Impact 2.6773 95.61 Very high (pLDDT > 90) AlphaFold Q16186 Q9Y5K5 A 345 A T mutation with no effect(MI:2226) Neutral 0.0021 78.42 Confident (90 > pLDDT > 70) AlphaFold Q16186 Q9Y5K5 A 324 A V mutation with no effect(MI:2226) Neutral 0.0125 72.89 Confident (90 > pLDDT > 70) AlphaFold Q16186 Q9Y5K5 A 327 I M mutation with no effect(MI:2226) Neutral 0.1365 80.58 Confident (90 > pLDDT > 70) AlphaFold Q16186 Q9Y5K5 A 163 M V mutation with no effect(MI:2226) Neutral 0 44.89 Very low (pLDDT < 50) AlphaFold Q16186 Q9Y5K5 A 279 G E mutation with no effect(MI:2226) Neutral 0 31.93 Very low (pLDDT < 50) AlphaFold Q16555 Q14195 A 496 R C mutation with no effect(MI:2226) Neutral 3.3146 90.04 Very high (pLDDT > 90) AlphaFold Q16555 Q14195 A 267 A S mutation with no effect(MI:2226) Neutral 0.0079 95.81 Very high (pLDDT > 90) AlphaFold Q16555 Q9BPU6 A 267 A S mutation with no effect(MI:2226) Neutral -0.0167 95.5 Very high (pLDDT > 90) AlphaFold Q16555 Q9BPU6 A 496 R C mutation with no effect(MI:2226) Neutral 3.2258 87.88 Confident (90 > pLDDT > 70) AlphaFold Q5TA45 Q9NV88 A 462 K E mutation with no effect(MI:2226) Neutral -1.0504 76.57 Confident (90 > pLDDT > 70) AlphaFold Q6IQ22 P31150 A 106 S A mutation with no effect(MI:2226) Neutral -1.7094 45.78 Very low (pLDDT < 50) AlphaFold Q6IQ22 P31150 A 106 S A mutation increasing strength(MI:1132) Impact -1.7094 45.78 Very low (pLDDT < 50) AlphaFold Q6IQ22 P31150 A 106 S E mutation disrupting strength(MI:1128) Impact -2.6207 45.78 Very low (pLDDT < 50) AlphaFold Q6IQ22 P31150 A 106 S E mutation(MI:0118) Neutral -2.6207 45.78 Very low (pLDDT < 50) AlphaFold Q7Z3B4 Q9BVL2 A 385 R K mutation with no effect(MI:2226) Neutral 0.044 90.47 Very high (pLDDT > 90) AlphaFold Q86YP4 Q9UBB5 A 149 K R mutation decreasing(MI:0119) Impact -0.0056 92.18 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 103 S E mutation with no effect(MI:2226) Neutral 0.0237 74.47 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 103 S A mutation with no effect(MI:2226) Neutral -0.0138 74.47 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 103 S K mutation with no effect(MI:2226) Neutral -0.3695 74.47 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 102 N A mutation with no effect(MI:2226) Neutral -0.0014 78.16 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 102 N K mutation with no effect(MI:2226) Neutral -0.0178 78.16 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 102 N E mutation with no effect(MI:2226) Neutral 0.0457 78.16 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 328 K E mutation with no effect(MI:2226) Neutral -0.0791 73.24 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 328 K A mutation with no effect(MI:2226) Neutral 0.4893 73.24 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 327 L E mutation with no effect(MI:2226) Neutral -0.0948 79.79 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 327 L K mutation with no effect(MI:2226) Neutral 0.3767 79.79 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 327 L A mutation with no effect(MI:2226) Neutral 0.6618 79.79 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 96 Y A mutation with no effect(MI:2226) Neutral -0.0292 95.07 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 96 Y E mutation with no effect(MI:2226) Neutral 0.2294 95.07 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 96 Y K mutation with no effect(MI:2226) Neutral -0.2509 95.07 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 100 K E mutation with no effect(MI:2226) Neutral 0.3333 89.04 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 100 K A mutation with no effect(MI:2226) Neutral 0.1482 89.04 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 97 I A mutation with no effect(MI:2226) Neutral 0 95.1 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 97 I E mutation with no effect(MI:2226) Neutral 0.0276 95.1 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 97 I K mutation disrupting strength(MI:1128) Impact -0.0028 95.1 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 95 L A mutation with no effect(MI:2226) Neutral -0.007 94.24 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 95 L E mutation disrupting strength(MI:1128) Impact 0.0207 94.24 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 95 L K mutation with no effect(MI:2226) Neutral 0.0053 94.24 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 229 G S mutation disrupting strength(MI:1128) Impact 1.1185 73.08 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 229 G E mutation with no effect(MI:2226) Neutral 2.4881 73.08 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 229 G K mutation with no effect(MI:2226) Neutral 0.4921 73.08 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 229 G A mutation with no effect(MI:2226) Neutral 1.4151 73.08 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 320 L K mutation with no effect(MI:2226) Neutral 1.8479 85.52 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 320 L E mutation with no effect(MI:2226) Neutral 0.8807 85.52 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 320 L A mutation with no effect(MI:2226) Neutral 1.4321 85.52 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 93 E A mutation with no effect(MI:2226) Neutral -0.04 89.51 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 93 E K mutation with no effect(MI:2226) Neutral -0.0185 89.51 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 168 W A mutation with no effect(MI:2226) Neutral 0 90.52 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 168 W E mutation with no effect(MI:2226) Neutral 0 90.52 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 168 W K mutation with no effect(MI:2226) Neutral 0 90.52 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 98 L E mutation with no effect(MI:2226) Neutral -0.0287 94.4 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 98 L K mutation with no effect(MI:2226) Neutral 0.0518 94.4 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 98 L A mutation with no effect(MI:2226) Neutral 0.022 94.4 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 101 C K mutation with no effect(MI:2226) Neutral -0.0648 83.45 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 101 C E mutation with no effect(MI:2226) Neutral 0.0248 83.45 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 101 C A mutation with no effect(MI:2226) Neutral -0.0028 83.45 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 228 S A mutation with no effect(MI:2226) Neutral 0.0171 72.98 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 228 S K mutation with no effect(MI:2226) Neutral 0.3037 72.98 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 228 S E mutation with no effect(MI:2226) Neutral 0.6203 72.98 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 333 L E mutation with no effect(MI:2226) Neutral 0.4015 73.05 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 333 L A mutation with no effect(MI:2226) Neutral 0.8245 73.05 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 333 L K mutation with no effect(MI:2226) Neutral -0.0035 73.05 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 331 F S mutation disrupting strength(MI:1128) Impact 0.2927 69.12 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 331 F E mutation disrupting strength(MI:1128) Impact 0.0314 69.12 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 331 F A mutation with no effect(MI:2226) Neutral 0.3338 69.12 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 331 F K mutation with no effect(MI:2226) Neutral -0.0442 69.12 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 227 Q K mutation with no effect(MI:2226) Neutral 0.0502 68.81 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 227 Q A mutation disrupting strength(MI:1128) Impact 0.1415 68.81 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 227 Q E mutation with no effect(MI:2226) Neutral 0.3544 68.81 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 155 L K mutation with no effect(MI:2226) Neutral -0.1441 87.12 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 155 L A mutation with no effect(MI:2226) Neutral -0.0374 87.12 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 155 L E mutation with no effect(MI:2226) Neutral 0.2367 87.12 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 235 F E mutation with no effect(MI:2226) Neutral 0.1636 93.2 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 235 F A mutation with no effect(MI:2226) Neutral 0.1463 93.2 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 235 F K mutation disrupting strength(MI:1128) Impact -0.0082 93.2 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 153 R A mutation with no effect(MI:2226) Neutral 1.7449 87.48 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 153 R E mutation with no effect(MI:2226) Neutral 2.0929 87.48 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 153 R K mutation with no effect(MI:2226) Neutral -0.7171 87.48 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 156 P E mutation with no effect(MI:2226) Neutral 0.1413 82.38 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 156 P A mutation with no effect(MI:2226) Neutral 0 82.38 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 156 P K mutation with no effect(MI:2226) Neutral -0.0738 82.38 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 104 T I mutation disrupting strength(MI:1128) Impact 0 83.01 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 104 T A mutation with no effect(MI:2226) Neutral -1e-4 83.01 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 104 T E mutation with no effect(MI:2226) Neutral 0.0158 83.01 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 104 T K mutation with no effect(MI:2226) Neutral -0.0026 83.01 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 231 Y E mutation with no effect(MI:2226) Neutral 1.5528 85.26 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 231 Y K mutation with no effect(MI:2226) Neutral 0.9427 85.26 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 231 Y A mutation disrupting strength(MI:1128) Impact 2.0762 85.26 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 114 V A mutation with no effect(MI:2226) Neutral 0 84.44 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 114 V K mutation with no effect(MI:2226) Neutral -0.1118 84.44 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 114 V E mutation with no effect(MI:2226) Neutral 0.0775 84.44 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 115 P E mutation with no effect(MI:2226) Neutral 0.0632 75.85 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 115 P K mutation with no effect(MI:2226) Neutral -0.0492 75.85 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 115 P A mutation with no effect(MI:2226) Neutral 0.003 75.85 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 115 P E mutation with no effect(MI:2226) Neutral 0.0632 75.85 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 325 E K mutation with no effect(MI:2226) Neutral 3.6254 86.87 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 325 E A mutation with no effect(MI:2226) Neutral 2.3995 86.87 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 94 A K mutation with no effect(MI:2226) Neutral 0.0038 91.47 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 94 A E mutation with no effect(MI:2226) Neutral 0.0223 91.47 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 318 E A mutation with no effect(MI:2226) Neutral 0.4754 82.6 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 318 E K mutation with no effect(MI:2226) Neutral -0.0023 82.6 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 326 K E mutation with no effect(MI:2226) Neutral -0.05 84.42 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 326 K A mutation with no effect(MI:2226) Neutral 0.017 84.42 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 154 L K mutation with no effect(MI:2226) Neutral 0.0044 88.99 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 154 L A mutation with no effect(MI:2226) Neutral 0.0018 88.99 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 154 L E mutation with no effect(MI:2226) Neutral 0.009 88.99 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 109 I K mutation with no effect(MI:2226) Neutral -0.339 94.36 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 109 I E mutation with no effect(MI:2226) Neutral -0.1963 94.36 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 109 I A mutation with no effect(MI:2226) Neutral -0.0656 94.36 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 222 I A mutation with no effect(MI:2226) Neutral 0.0686 92.91 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 222 I E mutation disrupting strength(MI:1128) Impact 0.0535 92.91 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 222 I K mutation with no effect(MI:2226) Neutral 0.0179 92.91 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 319 E A mutation with no effect(MI:2226) Neutral 0.10780000000000001 80.78 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 319 E K mutation with no effect(MI:2226) Neutral -0.7878 80.78 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 334 Q E mutation with no effect(MI:2226) Neutral 0.0546 68.34 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 334 Q A mutation with no effect(MI:2226) Neutral 0.071 68.34 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 334 Q K mutation with no effect(MI:2226) Neutral 0.1382 68.34 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 230 G A mutation with no effect(MI:2226) Neutral 0.0776 82.9 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 230 G K mutation with no effect(MI:2226) Neutral -0.0858 82.9 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 230 G E mutation with no effect(MI:2226) Neutral 0.2259 82.9 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 116 G A mutation with no effect(MI:2226) Neutral 0 74.93 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 116 G K mutation with no effect(MI:2226) Neutral -0.2155 74.93 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 116 G E mutation with no effect(MI:2226) Neutral 0.3064 74.93 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 315 V K mutation with no effect(MI:2226) Neutral -0.0168 88.81 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 315 V A mutation with no effect(MI:2226) Neutral 0.1575 88.81 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 315 V E mutation with no effect(MI:2226) Neutral 0.3153 88.81 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 108 F E mutation disrupting strength(MI:1128) Impact 0.0196 94.55 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 108 F K mutation with no effect(MI:2226) Neutral 2e-4 94.55 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 108 F A mutation with no effect(MI:2226) Neutral 0.0119 94.55 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 323 A K mutation with no effect(MI:2226) Neutral 3.461 91.32 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 323 A E mutation disrupting strength(MI:1128) Impact 3.7938 91.32 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 324 I A mutation with no effect(MI:2226) Neutral 1.7324 90.06 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 324 I E mutation with no effect(MI:2226) Neutral 1.8806 90.06 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 324 I K mutation with no effect(MI:2226) Neutral 1.4923 90.06 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 107 E A mutation with no effect(MI:2226) Neutral 0.0417 92.8 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 107 E K mutation with no effect(MI:2226) Neutral -1e-4 92.8 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 263 F K mutation with no effect(MI:2226) Neutral -0.0059 86.91 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 263 F E mutation with no effect(MI:2226) Neutral 0.0266 86.91 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 263 F A mutation with no effect(MI:2226) Neutral -0.0021 86.91 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 226 Q A mutation with no effect(MI:2226) Neutral -0.0083 76.71 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 226 Q K mutation with no effect(MI:2226) Neutral -0.0266 76.71 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 226 Q E mutation with no effect(MI:2226) Neutral 0.1108 76.71 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 224 S K mutation with no effect(MI:2226) Neutral 0.2101 88.92 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 224 S E mutation with no effect(MI:2226) Neutral 0.5376 88.92 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 224 S A mutation with no effect(MI:2226) Neutral 0.2786 88.92 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 82 R A mutation with no effect(MI:2226) Neutral -0.2762 89.63 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 82 R K mutation with no effect(MI:2226) Neutral -0.1634 89.63 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 82 R E mutation with no effect(MI:2226) Neutral 0.275 89.63 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 145 A T mutation disrupting strength(MI:1128) Impact 1.7407 81.75 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 145 A K mutation with no effect(MI:2226) Neutral -0.135 81.75 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 145 A E mutation with no effect(MI:2226) Neutral 1.668 81.75 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 303 F K mutation with no effect(MI:2226) Neutral 0.6161 55.52 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 303 F E mutation with no effect(MI:2226) Neutral 1.4382 55.52 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 303 F A mutation disrupting strength(MI:1128) Impact 1.0498 55.52 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 335 G E mutation with no effect(MI:2226) Neutral 0.0102 63.5 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 335 G A mutation with no effect(MI:2226) Neutral 0.0219 63.5 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 335 G K mutation with no effect(MI:2226) Neutral 0.0155 63.5 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 336 L E mutation with no effect(MI:2226) Neutral 1.2165 66.42 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 336 L K mutation with no effect(MI:2226) Neutral 0.0479 66.42 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 336 L A mutation with no effect(MI:2226) Neutral 0.9101 66.42 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 105 R K mutation with no effect(MI:2226) Neutral -0.0143 88.54 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 105 R A mutation with no effect(MI:2226) Neutral 0.038 88.54 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 105 R E mutation with no effect(MI:2226) Neutral -0.0443 88.54 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 232 V K mutation with no effect(MI:2226) Neutral 0.1429 88.64 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 232 V A mutation with no effect(MI:2226) Neutral 0.3773 88.64 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 232 V E mutation with no effect(MI:2226) Neutral 0.5138 88.64 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 332 T K mutation with no effect(MI:2226) Neutral -0.0075 74.41 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 332 T E mutation with no effect(MI:2226) Neutral 1e-4 74.41 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 332 T A mutation with no effect(MI:2226) Neutral 0.1665 74.41 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 92 T E mutation with no effect(MI:2226) Neutral 0.0123 88.38 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 92 T K mutation with no effect(MI:2226) Neutral -0.0281 88.38 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 92 T A mutation with no effect(MI:2226) Neutral 0.0085 88.38 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 91 Q E mutation with no effect(MI:2226) Neutral 0.0094 88.71 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 91 Q A mutation with no effect(MI:2226) Neutral -8e-4 88.71 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 91 Q K mutation with no effect(MI:2226) Neutral 5e-4 88.71 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 152 L A mutation with no effect(MI:2226) Neutral 0.0223 90.34 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 152 L K mutation with no effect(MI:2226) Neutral -0.0767 90.34 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 152 L E mutation with no effect(MI:2226) Neutral 0.2504 90.34 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 225 S E mutation with no effect(MI:2226) Neutral 0.2389 83.64 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 225 S K mutation with no effect(MI:2226) Neutral 0.4339 83.64 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 225 S A mutation with no effect(MI:2226) Neutral 0.7203 83.64 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 171 S K mutation with no effect(MI:2226) Neutral -0.9253 74.92 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 171 S E mutation with no effect(MI:2226) Neutral 0.9252 74.92 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 171 S A mutation with no effect(MI:2226) Neutral 0.9264 74.92 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 148 Q K mutation with no effect(MI:2226) Neutral -0.3183 78.4 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 148 Q A mutation with no effect(MI:2226) Neutral 0.2323 78.4 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 148 Q E mutation with no effect(MI:2226) Neutral 0.4252 78.4 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 134 S K mutation with no effect(MI:2226) Neutral -0.0428 86.47 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 134 S E mutation with no effect(MI:2226) Neutral 0.2017 86.47 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 134 S A mutation with no effect(MI:2226) Neutral 0.0095 86.47 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 223 E K mutation with no effect(MI:2226) Neutral -0.2163 91.36 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 223 E A mutation with no effect(MI:2226) Neutral -0.1056 91.36 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 264 G K mutation with no effect(MI:2226) Neutral -0.0195 84.51 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 264 G A mutation with no effect(MI:2226) Neutral 0.0513 84.51 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 264 G E mutation with no effect(MI:2226) Neutral -0.0932 84.51 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 265 V A mutation with no effect(MI:2226) Neutral 9e-4 83.94 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 265 V K mutation with no effect(MI:2226) Neutral -0.0274 83.94 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 265 V E mutation with no effect(MI:2226) Neutral 0.1302 83.94 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 268 E K mutation with no effect(MI:2226) Neutral -0.1152 61.19 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 268 E A mutation with no effect(MI:2226) Neutral -0.0679 61.19 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 173 D E mutation with no effect(MI:2226) Neutral 0.4456 67 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 173 D K mutation with no effect(MI:2226) Neutral -0.0267 67 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 173 D A mutation with no effect(MI:2226) Neutral -0.0214 67 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 131 Y A mutation with no effect(MI:2226) Neutral 0.0164 90.15 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 131 Y E mutation with no effect(MI:2226) Neutral 0.143 90.15 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 131 Y K mutation with no effect(MI:2226) Neutral -0.0167 90.15 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 322 L E mutation with no effect(MI:2226) Neutral 4.7382 91.03 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 322 L K mutation disrupting strength(MI:1128) Impact 5.2268 91.03 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 322 L A mutation with no effect(MI:2226) Neutral 4.1204 91.03 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 169 N A mutation with no effect(MI:2226) Neutral -0.4673 88.94 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 169 N K mutation with no effect(MI:2226) Neutral -1.0669 88.94 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 169 N E mutation with no effect(MI:2226) Neutral -0.0561 88.94 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 170 L K mutation with no effect(MI:2226) Neutral -0.1527 86.74 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 170 L A mutation with no effect(MI:2226) Neutral 0.0082 86.74 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 170 L E mutation with no effect(MI:2226) Neutral 0.0296 86.74 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 234 G E mutation with no effect(MI:2226) Neutral 0.3056 91.36 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 234 G A mutation disrupting strength(MI:1128) Impact -0.0039 91.36 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 234 G K mutation with no effect(MI:2226) Neutral -0.1694 91.36 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 146 L E mutation with no effect(MI:2226) Neutral 0.5574 88.19 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 146 L A mutation with no effect(MI:2226) Neutral -0.1268 88.19 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 146 L K mutation with no effect(MI:2226) Neutral -0.9107 88.19 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 300 V A mutation with no effect(MI:2226) Neutral 0.0047 49.47 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 300 V E mutation with no effect(MI:2226) Neutral 0.0299 49.47 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 300 V K mutation with no effect(MI:2226) Neutral -0.0023 49.47 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 81 T A mutation with no effect(MI:2226) Neutral -0.0269 90.15 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 81 T E mutation with no effect(MI:2226) Neutral -0.02 90.15 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 81 T K mutation with no effect(MI:2226) Neutral 0.0132 90.15 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 147 I E mutation with no effect(MI:2226) Neutral 0.0069 87.13 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 147 I A mutation with no effect(MI:2226) Neutral -0.0304 87.13 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 147 I K mutation with no effect(MI:2226) Neutral -0.1383 87.13 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 305 D K mutation with no effect(MI:2226) Neutral -0.0298 42.12 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 305 D E mutation with no effect(MI:2226) Neutral -0.014 42.12 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 305 D A mutation with no effect(MI:2226) Neutral -0.0246 42.12 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 135 K A mutation with no effect(MI:2226) Neutral 0.3287 85.49 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 135 K E mutation with no effect(MI:2226) Neutral 0.5997 85.49 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 266 D A mutation with no effect(MI:2226) Neutral -0.0133 70.19 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 266 D E mutation with no effect(MI:2226) Neutral 0.0066 70.19 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 266 D K mutation with no effect(MI:2226) Neutral -0.0272 70.19 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 142 L E mutation with no effect(MI:2226) Neutral 0.9114 85.94 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 142 L A mutation with no effect(MI:2226) Neutral 0.9173 85.94 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 142 L K mutation with no effect(MI:2226) Neutral -0.6769 85.94 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 337 W E mutation with no effect(MI:2226) Neutral 1.4867 60.77 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 337 W A mutation with no effect(MI:2226) Neutral 1.6712 60.77 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 337 W K mutation with no effect(MI:2226) Neutral 0.9552 60.77 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 233 L E mutation with no effect(MI:2226) Neutral 0.8668 89.68 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 233 L K mutation with no effect(MI:2226) Neutral -0.0578 89.68 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 233 L A mutation disrupting strength(MI:1128) Impact 0.6121 89.68 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 132 E A mutation with no effect(MI:2226) Neutral -0.3573 84.12 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 132 E K mutation with no effect(MI:2226) Neutral -1.3762 84.12 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 317 S A mutation with no effect(MI:2226) Neutral 0.2908 87.51 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 317 S E mutation with no effect(MI:2226) Neutral 0.6531 87.51 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 317 S K mutation with no effect(MI:2226) Neutral 0.0356 87.51 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 150 K A mutation with no effect(MI:2226) Neutral -0.0445 83.19 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 150 K E mutation with no effect(MI:2226) Neutral -0.1001 83.19 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 149 N A mutation with no effect(MI:2226) Neutral -0.031 80.09 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 149 N E mutation with no effect(MI:2226) Neutral -0.021 80.09 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 149 N K mutation with no effect(MI:2226) Neutral 0.0345 80.09 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 321 G K mutation with no effect(MI:2226) Neutral 7.0898 85.55 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 321 G A mutation with no effect(MI:2226) Neutral 2.1946 85.55 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 321 G E mutation with no effect(MI:2226) Neutral 9.0164 85.55 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 84 A E mutation with no effect(MI:2226) Neutral -0.0049 87.34 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 84 A K mutation with no effect(MI:2226) Neutral 0.0036 87.34 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 83 T A mutation disrupting strength(MI:1128) Impact -0.0125 88.2 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 83 T K mutation with no effect(MI:2226) Neutral 0.042 88.2 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 83 T E mutation with no effect(MI:2226) Neutral 0.2738 88.2 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 302 Y K mutation disrupting strength(MI:1128) Impact 0.1792 54.61 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 302 Y E mutation with no effect(MI:2226) Neutral 0.5015 54.61 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 302 Y A mutation with no effect(MI:2226) Neutral 0.5128 54.61 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 304 A K mutation with no effect(MI:2226) Neutral 3e-4 47.15 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 304 A E mutation with no effect(MI:2226) Neutral 0.2472 47.15 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 11 R A mutation disrupting strength(MI:1128) Impact 0.1093 85.99 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 11 R E mutation disrupting strength(MI:1128) Impact 0.2241 85.99 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 11 R W mutation disrupting strength(MI:1128) Impact 0.1651 85.99 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 11 R K mutation with no effect(MI:2226) Neutral 0.074 85.99 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 76 I T mutation disrupting strength(MI:1128) Impact -0.019 92.24 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 76 I A mutation with no effect(MI:2226) Neutral 0 92.24 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 76 I K mutation with no effect(MI:2226) Neutral -0.0031 92.24 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 76 I E mutation disrupting strength(MI:1128) Impact -0.1008 92.24 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 172 S A mutation with no effect(MI:2226) Neutral 0.0364 70.61 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 172 S K mutation with no effect(MI:2226) Neutral -1.2243 70.61 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 172 S E mutation with no effect(MI:2226) Neutral 0.0987 70.61 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 130 A E mutation with no effect(MI:2226) Neutral 0.1427 85.6 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 130 A K mutation disrupting strength(MI:1128) Impact -2e-4 85.6 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 128 H A mutation with no effect(MI:2226) Neutral -0.2263 90.78 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 128 H E mutation with no effect(MI:2226) Neutral 0.1075 90.78 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 128 H K mutation with no effect(MI:2226) Neutral -0.0789 90.78 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 126 A E mutation with no effect(MI:2226) Neutral 0.0659 88.11 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 126 A K mutation with no effect(MI:2226) Neutral -0.1075 88.11 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 151 Q A mutation with no effect(MI:2226) Neutral 0.1504 86.31 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 151 Q E mutation with no effect(MI:2226) Neutral 0.1423 86.31 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 151 Q K mutation with no effect(MI:2226) Neutral -0.0159 86.31 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 129 R A mutation with no effect(MI:2226) Neutral 0.6875 86.63 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 129 R E mutation with no effect(MI:2226) Neutral 0.5282 86.63 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 129 R K mutation with no effect(MI:2226) Neutral 0.2286 86.63 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 176 N K mutation with no effect(MI:2226) Neutral 0.1203 83.39 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 176 N A mutation with no effect(MI:2226) Neutral 0.0014 83.39 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 176 N E mutation with no effect(MI:2226) Neutral 0.0454 83.39 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 270 E A mutation with no effect(MI:2226) Neutral -0.1614 52.04 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 270 E K mutation with no effect(MI:2226) Neutral -0.189 52.04 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 205 Q A mutation with no effect(MI:2226) Neutral 0.0044 88.92 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 205 Q E mutation with no effect(MI:2226) Neutral 0.0487 88.92 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 205 Q K mutation with no effect(MI:2226) Neutral -0.1047 88.92 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 316 F E mutation with no effect(MI:2226) Neutral 1.6785 88.34 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 316 F A mutation with no effect(MI:2226) Neutral 2.314 88.34 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 316 F K mutation with no effect(MI:2226) Neutral 1.5492 88.34 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 144 S K mutation with no effect(MI:2226) Neutral -0.6247 82.93 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 144 S E mutation with no effect(MI:2226) Neutral 1.6282 82.93 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 144 S A mutation with no effect(MI:2226) Neutral 0.3008 82.93 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 221 V A mutation with no effect(MI:2226) Neutral 0.0365 93.11 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 221 V E mutation with no effect(MI:2226) Neutral 0.1605 93.11 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 221 V K mutation with no effect(MI:2226) Neutral -0.1698 93.11 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 307 N K mutation with no effect(MI:2226) Neutral -0.007 40.13 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 307 N E mutation with no effect(MI:2226) Neutral 0.0069 40.13 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 307 N A mutation with no effect(MI:2226) Neutral 2e-4 40.13 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 141 K E mutation with no effect(MI:2226) Neutral 0.3502 88.02 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 141 K A mutation with no effect(MI:2226) Neutral 0.3183 88.02 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 119 R K mutation with no effect(MI:2226) Neutral 0.0195 86.54 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 119 R E mutation with no effect(MI:2226) Neutral 0.2397 86.54 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 119 R A mutation with no effect(MI:2226) Neutral 0.0855 86.54 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 121 F A mutation with no effect(MI:2226) Neutral -0.032 90.56 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 121 F K mutation with no effect(MI:2226) Neutral 0.0304 90.56 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 121 F E mutation with no effect(MI:2226) Neutral 0.0124 90.56 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 125 M A mutation with no effect(MI:2226) Neutral -0.0172 90.96 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 125 M E mutation with no effect(MI:2226) Neutral 0.1523 90.96 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 125 M K mutation with no effect(MI:2226) Neutral -0.1155 90.96 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 133 T A mutation with no effect(MI:2226) Neutral -0.0039 80.96 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 133 T I mutation disrupting strength(MI:1128) Impact -0.0368 80.96 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 133 T E mutation with no effect(MI:2226) Neutral 0.2731 80.96 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 133 T K mutation with no effect(MI:2226) Neutral -0.3138 80.96 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 299 F E mutation with no effect(MI:2226) Neutral 0.4407 48.36 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 299 F K mutation with no effect(MI:2226) Neutral 0.884 48.36 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 299 F A mutation with no effect(MI:2226) Neutral 0.6201 48.36 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 215 K E mutation with no effect(MI:2226) Neutral 0.0814 81.7 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 215 K A mutation with no effect(MI:2226) Neutral 0.0333 81.7 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 312 R E mutation with no effect(MI:2226) Neutral 2.4496000000000002 77.03 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 312 R A mutation with no effect(MI:2226) Neutral 2.4349 77.03 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 312 R K mutation with no effect(MI:2226) Neutral 3.4566 77.03 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 198 N E mutation with no effect(MI:2226) Neutral -0.1852 89.96 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 198 N K mutation with no effect(MI:2226) Neutral -0.1174 89.96 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 198 N A mutation with no effect(MI:2226) Neutral -0.2927 89.96 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 80 T K mutation with no effect(MI:2226) Neutral -0.1234 91.57 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 80 T E mutation with no effect(MI:2226) Neutral 0.0568 91.57 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 80 T A mutation disrupting strength(MI:1128) Impact -0.0375 91.57 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 80 T I mutation disrupting strength(MI:1128) Impact 0.0155 91.57 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 313 E K mutation with no effect(MI:2226) Neutral -0.0619 79.54 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 313 E A mutation with no effect(MI:2226) Neutral 0.0011 79.54 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 117 S K mutation with no effect(MI:2226) Neutral -0.2131 81.83 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 117 S E mutation with no effect(MI:2226) Neutral 0.0886 81.83 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 117 S A mutation with no effect(MI:2226) Neutral 0 81.83 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 189 W K mutation with no effect(MI:2226) Neutral 0.0933 94.18 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 189 W A mutation with no effect(MI:2226) Neutral 0.1102 94.18 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 189 W E mutation with no effect(MI:2226) Neutral 0.0718 94.18 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 136 M A mutation with no effect(MI:2226) Neutral 0.0114 85.35 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 136 M K mutation with no effect(MI:2226) Neutral -0.2583 85.35 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 136 M E mutation with no effect(MI:2226) Neutral 0.7563 85.35 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 174 Q A mutation with no effect(MI:2226) Neutral 0.0046 68.03 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 174 Q K mutation with no effect(MI:2226) Neutral 0 68.03 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 174 Q E mutation with no effect(MI:2226) Neutral -0.0046 68.03 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 175 G A mutation with no effect(MI:2226) Neutral 5e-4 72.28 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 175 G K mutation with no effect(MI:2226) Neutral -0.017 72.28 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 175 G E mutation with no effect(MI:2226) Neutral 0.0119 72.28 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 118 P K mutation with no effect(MI:2226) Neutral -0.0086 84.5 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 118 P A mutation with no effect(MI:2226) Neutral 0 84.5 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 118 P E mutation with no effect(MI:2226) Neutral 0.2467 84.5 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 341 S A mutation with no effect(MI:2226) Neutral 0.0039 29.58 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 341 S K mutation with no effect(MI:2226) Neutral -0.736 29.58 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 341 S E mutation with no effect(MI:2226) Neutral -0.9315 29.58 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 339 V A mutation with no effect(MI:2226) Neutral 0.0325 46.43 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 339 V K mutation with no effect(MI:2226) Neutral 0.0286 46.43 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 339 V E mutation with no effect(MI:2226) Neutral 0.0216 46.43 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 202 P A mutation with no effect(MI:2226) Neutral 0.0518 92.16 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 202 P K mutation with no effect(MI:2226) Neutral 0.0443 92.16 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 202 P E mutation with no effect(MI:2226) Neutral 0.0974 92.16 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 201 I K mutation with no effect(MI:2226) Neutral -0.102 93.49 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 201 I A mutation with no effect(MI:2226) Neutral 0.0908 93.49 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 201 I E mutation with no effect(MI:2226) Neutral 0.0706 93.49 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 195 D K mutation with no effect(MI:2226) Neutral 0.0806 81.49 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 195 D E mutation with no effect(MI:2226) Neutral -0.0538 81.49 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 195 D A mutation with no effect(MI:2226) Neutral -0.0199 81.49 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 216 F A mutation with no effect(MI:2226) Neutral 0.0255 80.98 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 216 F E mutation with no effect(MI:2226) Neutral -0.0025 80.98 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 216 F K mutation with no effect(MI:2226) Neutral -0.0085 80.98 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 139 D A mutation with no effect(MI:2226) Neutral 0.5535 85.91 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 139 D K mutation with no effect(MI:2226) Neutral 0.3994 85.91 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 139 D E mutation with no effect(MI:2226) Neutral 0.7603 85.91 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 77 L E mutation with no effect(MI:2226) Neutral 0.288 88.67 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 77 L A mutation with no effect(MI:2226) Neutral 0.0699 88.67 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 77 L K mutation with no effect(MI:2226) Neutral -0.1472 88.67 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 314 P K mutation with no effect(MI:2226) Neutral 1.3406 87.21 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 314 P E mutation with no effect(MI:2226) Neutral 0.4443 87.21 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 314 P A mutation with no effect(MI:2226) Neutral 0.7084 87.21 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 190 H A mutation with no effect(MI:2226) Neutral 9e-4 92 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 190 H E mutation with no effect(MI:2226) Neutral -0.0344 92 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 190 H K mutation with no effect(MI:2226) Neutral 0.0046 92 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 79 I K mutation with no effect(MI:2226) Neutral -0.1678 92.02 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 79 I A mutation with no effect(MI:2226) Neutral 6e-4 92.02 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 79 I E mutation with no effect(MI:2226) Neutral -0.0709 92.02 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 311 D E mutation with no effect(MI:2226) Neutral -0.1262 66.59 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 311 D K mutation with no effect(MI:2226) Neutral -0.2022 66.59 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 311 D A mutation with no effect(MI:2226) Neutral -0.0413 66.59 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 143 R K mutation with no effect(MI:2226) Neutral 1.1534 83.57 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 143 R E mutation with no effect(MI:2226) Neutral 1.7479 83.57 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 143 R A mutation with no effect(MI:2226) Neutral 1.8247 83.57 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 340 M A mutation with no effect(MI:2226) Neutral 1.9681 41.04 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 340 M E mutation with no effect(MI:2226) Neutral 1.5749 41.04 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 340 M K mutation with no effect(MI:2226) Neutral 1.5257 41.04 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 186 R A mutation with no effect(MI:2226) Neutral 0.3139 92.98 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 186 R K mutation disrupting strength(MI:1128) Impact 0.2088 92.98 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 186 R E mutation disrupting strength(MI:1128) Impact 0.451 92.98 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 74 N E mutation with no effect(MI:2226) Neutral 0.2402 89.56 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 74 N K mutation with no effect(MI:2226) Neutral -0.1296 89.56 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 74 N A mutation with no effect(MI:2226) Neutral 0 89.56 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 197 F A mutation with no effect(MI:2226) Neutral 0.2428 84.86 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 197 F K mutation with no effect(MI:2226) Neutral 0.6975 84.86 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 197 F E mutation with no effect(MI:2226) Neutral -0.035 84.86 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 138 R K mutation with no effect(MI:2226) Neutral 0.9636 87.48 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 138 R E mutation with no effect(MI:2226) Neutral 0.7886 87.48 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 138 R A mutation with no effect(MI:2226) Neutral 1.1144 87.48 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 338 E K mutation with no effect(MI:2226) Neutral 0.0889 49.95 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 338 E A mutation with no effect(MI:2226) Neutral 0.0768 49.95 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 310 Q K mutation with no effect(MI:2226) Neutral 0.1157 56.79 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 310 Q E mutation with no effect(MI:2226) Neutral 0.5027 56.79 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 310 Q A mutation with no effect(MI:2226) Neutral 0.4964 56.79 Low (70 > pLDDT > 50) AlphaFold Q8N3I7 Q3SYG4 A 140 F E mutation with no effect(MI:2226) Neutral 0.8901 89.61 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 140 F A mutation with no effect(MI:2226) Neutral 0.5991 89.61 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 140 F K mutation with no effect(MI:2226) Neutral 0.0035 89.61 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 75 C A mutation with no effect(MI:2226) Neutral -4e-4 91.04 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 75 C E mutation with no effect(MI:2226) Neutral 0.2065 91.04 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 75 C K mutation with no effect(MI:2226) Neutral -0.0935 91.04 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 309 Q A mutation with no effect(MI:2226) Neutral -2e-4 48.37 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 309 Q E mutation with no effect(MI:2226) Neutral -0.0068 48.37 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 309 Q K mutation disrupting strength(MI:1128) Impact -0.0049 48.37 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 78 N A mutation with no effect(MI:2226) Neutral -0.1417 89.62 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 78 N K mutation with no effect(MI:2226) Neutral -0.0621 89.62 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 78 N E mutation with no effect(MI:2226) Neutral -0.0456 89.62 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 200 S A mutation with no effect(MI:2226) Neutral -0.0215 93.14 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 200 S K mutation with no effect(MI:2226) Neutral -0.3803 93.14 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 200 S E mutation with no effect(MI:2226) Neutral 0.3397 93.14 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 308 K E mutation with no effect(MI:2226) Neutral 1.1315 49.18 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 308 K A mutation with no effect(MI:2226) Neutral 1.0914 49.18 Very low (pLDDT < 50) AlphaFold Q8N3I7 Q3SYG4 A 41 K E mutation with no effect(MI:2226) Neutral 0.0126 89.28 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 41 K A mutation with no effect(MI:2226) Neutral 1e-4 89.28 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 73 Y K mutation with no effect(MI:2226) Neutral -0.0061 93.41 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 73 Y A mutation with no effect(MI:2226) Neutral 0 93.41 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 73 Y E mutation with no effect(MI:2226) Neutral -0.1158 93.41 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 196 S A mutation with no effect(MI:2226) Neutral -1.434 78.06 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 196 S K mutation with no effect(MI:2226) Neutral -0.7479 78.06 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 196 S E mutation with no effect(MI:2226) Neutral -0.1521 78.06 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 137 Y K mutation with no effect(MI:2226) Neutral 0.012 89.57 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 137 Y A mutation with no effect(MI:2226) Neutral -0.0983 89.57 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 137 Y E mutation with no effect(MI:2226) Neutral 0.0487 89.57 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 191 A K mutation with no effect(MI:2226) Neutral -0.0168 89.54 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 191 A E mutation with no effect(MI:2226) Neutral -0.0333 89.54 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 199 V K mutation with no effect(MI:2226) Neutral 0.5474 92.13 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 199 V A mutation with no effect(MI:2226) Neutral 0.1196 92.13 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 199 V E mutation with no effect(MI:2226) Neutral 0.173 92.13 Very high (pLDDT > 90) AlphaFold Q8N3I7 Q3SYG4 A 194 N A mutation with no effect(MI:2226) Neutral 0.22 78.56 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 194 N K mutation with no effect(MI:2226) Neutral 0.7094 78.56 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 194 N E mutation with no effect(MI:2226) Neutral 0.3147 78.56 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 193 M A mutation with no effect(MI:2226) Neutral -0.0133 83.76 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 193 M E mutation with no effect(MI:2226) Neutral -0.0122 83.76 Confident (90 > pLDDT > 70) AlphaFold Q8N3I7 Q3SYG4 A 193 M K mutation with no effect(MI:2226) Neutral -0.0133 83.76 Confident (90 > pLDDT > 70) AlphaFold Q8N3U4 Q96FF9 A 793 D K mutation disrupting(MI:0573) Impact -0.2206 91.94 Very high (pLDDT > 90) AlphaFold Q8NHZ8 Q13042 A 37 E Q mutation with no effect(MI:2226) Neutral -0.0415 53.09 Low (70 > pLDDT > 50) AlphaFold Q8NHZ8 Q13042 A 21 N S mutation with no effect(MI:2226) Neutral -0.1557 86.42 Confident (90 > pLDDT > 70) AlphaFold Q8WUM0 P57740 A 974 S R mutation decreasing strength(MI:1133) Impact -1.6373 92.58 Very high (pLDDT > 90) AlphaFold Q8WUM0 P57740 A 974 S R mutation decreasing strength(MI:1133) Impact -1.6373 92.58 Very high (pLDDT > 90) AlphaFold Q96B26 Q9NQT4 A 202 D V mutation disrupting strength(MI:1128) Impact 0.0986 78.75 Confident (90 > pLDDT > 70) AlphaFold Q99719 Q92599 A 38 S A mutation with no effect(MI:2226) Neutral -0.1728 84.52 Confident (90 > pLDDT > 70) AlphaFold Q9BPX6 Q8IYU8 A 463 C S mutation with no effect(MI:2226) Neutral -0.2844 35.41 Very low (pLDDT < 50) AlphaFold Q9BPX6 Q8IYU8 A 463 C S mutation with no effect(MI:2226) Neutral -0.2844 35.41 Very low (pLDDT < 50) AlphaFold Q9BSQ5 O00522 A 217 F A mutation decreasing strength(MI:1133) Impact 1.5235 86.65 Confident (90 > pLDDT > 70) AlphaFold Q9BSQ5 O00522 A 210 C D mutation disrupting strength(MI:1128) Impact 1.0727 90.39 Very high (pLDDT > 90) AlphaFold Q9BSQ5 O00522 A 210 C D mutation decreasing strength(MI:1133) Impact 1.0727 90.39 Very high (pLDDT > 90) AlphaFold Q9BUE0 Q9H944 A 19 M V mutation with no effect(MI:2226) Neutral -0.2566 92.76 Very high (pLDDT > 90) AlphaFold Q9BUL8 Q9Y6E0 A 20 M V mutation with no effect(MI:2226) Neutral 0.004 85.25 Confident (90 > pLDDT > 70) AlphaFold Q9BV68 P46379 A 68 V M mutation with no effect(MI:2226) Neutral -7.5e-4 29.53 Very low (pLDDT < 50) AlphaFold Q9H269 Q96AX1 A 669 A D mutation decreasing(MI:0119) Impact 1.7147 96.23 Very high (pLDDT > 90) AlphaFold Q9H269 Q96AX1 A 725 R E mutation disrupting(MI:0573) Impact 5.8182 91.95 Very high (pLDDT > 90) AlphaFold Q9H334 O15409 A 514 R C mutation decreasing strength(MI:1133) Impact -0.0166 94.49 Very high (pLDDT > 90) AlphaFold Q9H334 O15409 A 514 R C mutation decreasing strength(MI:1133) Impact -0.0166 94.49 Very high (pLDDT > 90) AlphaFold Q9NYB0 Q15554 A 318 I R mutation disrupting(MI:0573) Impact 3.0824 95.19 Very high (pLDDT > 90) AlphaFold Q9NYB0 Q15554 A 318 I R mutation disrupting(MI:0573) Impact 3.0824 95.19 Very high (pLDDT > 90) AlphaFold Q9NYB0 Q15554 A 318 I R mutation disrupting(MI:0573) Impact 3.0824 95.19 Very high (pLDDT > 90) AlphaFold Q9NYB0 Q15554 A 336 F R mutation disrupting(MI:0573) Impact 1.7562 95.15 Very high (pLDDT > 90) AlphaFold Q9NYB0 Q15554 A 336 F R mutation disrupting(MI:0573) Impact 1.7562 95.15 Very high (pLDDT > 90) AlphaFold Q9NYB0 Q15554 A 336 F R mutation disrupting(MI:0573) Impact 1.7562 95.15 Very high (pLDDT > 90) AlphaFold Q9UBQ0 Q96QK1 A 92 P G mutation disrupting strength(MI:1128) Impact 2.1609 94.06 Very high (pLDDT > 90) AlphaFold Q9UBQ0 Q96QK1 A 92 P A mutation disrupting strength(MI:1128) Impact 2.7774 94.06 Very high (pLDDT > 90) AlphaFold Q9UBQ0 Q96QK1 A 93 W A mutation disrupting strength(MI:1128) Impact 1.781 94.81 Very high (pLDDT > 90) AlphaFold Q9UBQ0 Q96QK1 A 93 W D mutation disrupting strength(MI:1128) Impact 2.1214 94.81 Very high (pLDDT > 90) AlphaFold Q9UBQ0 Q96QK1 A 94 G P mutation disrupting strength(MI:1128) Impact 0.2446 92.85 Very high (pLDDT > 90) AlphaFold Q9UBQ0 Q96QK1 A 104 R D mutation disrupting strength(MI:1128) Impact 1.1429 95.17 Very high (pLDDT > 90) AlphaFold Q9UBT2 Q9UBE0 A 85 P L mutation disrupting strength(MI:1128) Impact -0.1872 88.29 Confident (90 > pLDDT > 70) AlphaFold Q9UI10 P49770 A 391 A D mutation disrupting strength(MI:1128) Impact 0.8663 91.99 Very high (pLDDT > 90) AlphaFold Q9UI10 P49770 A 391 A D mutation disrupting strength(MI:1128) Impact 0.8663 91.99 Very high (pLDDT > 90) AlphaFold Q9Y248 Q9BRT9 A 150 L S mutation with no effect(MI:2226) Neutral 0.9633 94.82 Very high (pLDDT > 90) AlphaFold Q9Y248 Q9BRT9 A 24 D G mutation with no effect(MI:2226) Neutral 0.0296 94.59 Very high (pLDDT > 90) AlphaFold Q9Y248 Q9BRT9 A 26 I T mutation with no effect(MI:2226) Neutral 0.3494 94.59 Very high (pLDDT > 90) AlphaFold Q9Y248 Q9BRT9 A 172 T K mutation with no effect(MI:2226) Neutral -0.3855 84.34 Confident (90 > pLDDT > 70) AlphaFold Q9Y265 Q9Y230 A 365 L Q mutation with no effect(MI:2226) Neutral 0 84.85 Confident (90 > pLDDT > 70) AlphaFold Q9Y294 P54198 A 37 D A mutation disrupting(MI:0573) Impact 0.0823 91.97 Very high (pLDDT > 90) AlphaFold Q9Y294 P54198 A 37 D A mutation disrupting(MI:0573) Impact 0.0823 91.97 Very high (pLDDT > 90) AlphaFold Q9Y2H1 Q9H8S9 A 32 Y A mutation disrupting(MI:0573) Impact 0.4739 78.44 Confident (90 > pLDDT > 70) AlphaFold Q9Y3B2 Q9NQT4 A 10 P L mutation disrupting strength(MI:1128) Impact 0.5506 88.27 Confident (90 > pLDDT > 70) AlphaFold O14977 Q9UMX2 B 193 R Q mutation with no effect(MI:2226) Neutral 0.456 78 Confident (90 > pLDDT > 70) AlphaFold O14977 Q9UMX2 B 174 V A mutation with no effect(MI:2226) Neutral 0.1611 88 Confident (90 > pLDDT > 70) AlphaFold O43402 Q15006 B 227 R A mutation disrupting strength(MI:1128) Impact 3.119 96 Very high (pLDDT > 90) AlphaFold O43402 Q15006 B 171 Y A mutation with no effect(MI:2226) Neutral 0.4065 98 Very high (pLDDT > 90) AlphaFold O43402 Q15006 B 160 E A mutation with no effect(MI:2226) Neutral -0.1545 95 Very high (pLDDT > 90) AlphaFold O43402 Q15006 B 200 Y A mutation disrupting strength(MI:1128) Impact 2.3677 98 Very high (pLDDT > 90) AlphaFold O43402 Q15006 B 28 R A mutation with no effect(MI:2226) Neutral -0.7529 84 Confident (90 > pLDDT > 70) AlphaFold O60216 Q8N3U4 B 327 S N mutation decreasing(MI:0119) Impact -0.8526 91 Very high (pLDDT > 90) AlphaFold O60216 Q8N3U4 B 327 S N mutation with no effect(MI:2226) Neutral -0.8526 91 Very high (pLDDT > 90) AlphaFold O60216 Q8N3U4 B 327 S N mutation decreasing(MI:0119) Impact -0.8526 91 Very high (pLDDT > 90) AlphaFold O60216 Q8N3U4 B 327 S N mutation(MI:0118) Neutral -0.8526 91 Very high (pLDDT > 90) AlphaFold O60216 Q8N3U4 B 793 D K mutation disrupting strength(MI:1128) Impact 0.5669 96 Very high (pLDDT > 90) AlphaFold O60216 Q8N3U4 B 793 D K mutation disrupting strength(MI:1128) Impact 0.5669 96 Very high (pLDDT > 90) AlphaFold O60216 Q8N3U4 B 793 D K mutation disrupting(MI:0573) Impact 0.5669 96 Very high (pLDDT > 90) AlphaFold O75771 O43543 B 160 V I mutation with no effect(MI:2226) Neutral -0.39 87 Confident (90 > pLDDT > 70) AlphaFold P02792 P02794 B 54 K R mutation with no effect(MI:2226) Neutral -0.0344 97 Very high (pLDDT > 90) AlphaFold P02792 P02794 B 54 K R mutation with no effect(MI:2226) Neutral -0.0344 97 Very high (pLDDT > 90) AlphaFold P02792 P02794 B 54 K R mutation with no effect(MI:2226) Neutral -0.0344 97 Very high (pLDDT > 90) AlphaFold P06756 P05556 B 752 K E mutation disrupting(MI:0573) Impact -1.2409 75 Confident (90 > pLDDT > 70) AlphaFold P09467 O00757 B 216 Y C mutation with no effect(MI:2226) Neutral 0.5073 93 Very high (pLDDT > 90) AlphaFold P11802 P42773 B 69 T A mutation with no effect(MI:2226) Neutral 0.41163 75 Confident (90 > pLDDT > 70) AlphaFold P11926 Q9UMX2 B 193 R Q mutation disrupting strength(MI:1128) Impact 0.44934 72 Confident (90 > pLDDT > 70) AlphaFold P12956 Q8IW19 B 182 R E mutation disrupting(MI:0573) Impact 0.2693 32 Very low (pLDDT < 50) AlphaFold P12956 Q8IW19 B 182 R E mutation disrupting(MI:0573) Impact 0.2693 32 Very low (pLDDT < 50) AlphaFold P12956 Q8IW19 B 184 R E mutation decreasing(MI:0119) Impact 0.27096 37 Very low (pLDDT < 50) AlphaFold P12956 Q8IW19 B 184 R E mutation decreasing(MI:0119) Impact 0.27096 37 Very low (pLDDT < 50) AlphaFold P12956 Q8IW19 B 189 W G mutation disrupting(MI:0573) Impact 0.67078 52 Low (70 > pLDDT > 50) AlphaFold P12956 Q8IW19 B 189 W G mutation disrupting(MI:0573) Impact 0.67078 52 Low (70 > pLDDT > 50) AlphaFold P12956 Q8IW19 B 183 K E mutation disrupting(MI:0573) Impact 0.11177 33 Very low (pLDDT < 50) AlphaFold P12956 Q8IW19 B 183 K E mutation disrupting(MI:0573) Impact 0.11177 33 Very low (pLDDT < 50) AlphaFold P13010 Q8IW19 B 189 W G mutation disrupting(MI:0573) Impact 4.153 88 Confident (90 > pLDDT > 70) AlphaFold P13010 Q8IW19 B 189 W G mutation disrupting(MI:0573) Impact 4.153 88 Confident (90 > pLDDT > 70) AlphaFold P13010 Q8IW19 B 189 W G mutation disrupting(MI:0573) Impact 4.153 88 Confident (90 > pLDDT > 70) AlphaFold P13010 Q8IW19 B 183 K E mutation disrupting(MI:0573) Impact 0.6552 67 Low (70 > pLDDT > 50) AlphaFold P13010 Q8IW19 B 183 K E mutation disrupting(MI:0573) Impact 0.6552 67 Low (70 > pLDDT > 50) AlphaFold P13010 Q8IW19 B 184 R E mutation decreasing(MI:0119) Impact 6.9771 84 Confident (90 > pLDDT > 70) AlphaFold P13010 Q8IW19 B 184 R E mutation decreasing(MI:0119) Impact 6.9771 84 Confident (90 > pLDDT > 70) AlphaFold P13010 Q8IW19 B 182 R E mutation disrupting(MI:0573) Impact 0.2495 51 Low (70 > pLDDT > 50) AlphaFold P13010 Q8IW19 B 182 R E mutation disrupting(MI:0573) Impact 0.2495 51 Low (70 > pLDDT > 50) AlphaFold P17980 O00233 B 134 R W mutation with no effect(MI:2226) Neutral 0.041132 73 Confident (90 > pLDDT > 70) AlphaFold P18754 P62826 B 70 E A mutation(MI:0118) Neutral -0.23075 64 Low (70 > pLDDT > 50) AlphaFold P23528 P60709 B 372 R C mutation with no effect(MI:2226) Neutral -0.00262 87 Confident (90 > pLDDT > 70) AlphaFold P26196 Q96F86 B 213 F L mutation disrupting strength(MI:1128) Impact 1.1595 88 Confident (90 > pLDDT > 70) AlphaFold P31150 P61006 B 72 T A mutation(MI:0118) Neutral -0.094 43 Very low (pLDDT < 50) AlphaFold P31150 P61006 B 72 T E mutation(MI:0118) Neutral -0.2017 43 Very low (pLDDT < 50) AlphaFold P35249 P40937 B 131 T N mutation with no effect(MI:2226) Neutral 0.0296 89 Confident (90 > pLDDT > 70) AlphaFold P35249 P40937 B 213 M T mutation disrupting strength(MI:1128) Impact -0.0057 91 Very high (pLDDT > 90) AlphaFold P37198 Q7Z3B4 B 385 R K mutation with no effect(MI:2226) Neutral 2.015 89 Confident (90 > pLDDT > 70) AlphaFold P43686 P62195 B 258 R W mutation with no effect(MI:2226) Neutral 0.1438 59 Low (70 > pLDDT > 50) AlphaFold P50213 P51553 B 136 R Q mutation decreasing(MI:0119) Impact 0.562 93 Very high (pLDDT > 90) AlphaFold P50213 P51553 B 190 K A mutation(MI:0118) Neutral 0.9803 95 Very high (pLDDT > 90) AlphaFold P51531 Q12824 B 366 R C mutation(MI:0118) Neutral 0.4119 68 Low (70 > pLDDT > 50) AlphaFold P51531 Q12824 B 377 R C mutation(MI:0118) Neutral 0.0484 47 Very low (pLDDT < 50) AlphaFold P51531 Q12824 B 377 R C mutation(MI:0118) Neutral 0.0484 47 Very low (pLDDT < 50) AlphaFold P51531 Q12824 B 363 K N mutation with no effect(MI:2226) Neutral -0.0223 76 Confident (90 > pLDDT > 70) AlphaFold P52655 P52657 B 109 E A mutation decreasing(MI:0119) Impact -0.0091 31 Very low (pLDDT < 50) AlphaFold P52655 P52657 B 41 D A mutation decreasing(MI:0119) Impact -0.3754 95 Very high (pLDDT > 90) AlphaFold P52655 P52657 B 40 F A mutation decreasing(MI:0119) Impact 0.6362 97 Very high (pLDDT > 90) AlphaFold P52655 P52657 B 42 K A mutation decreasing(MI:0119) Impact 0.6423 94 Very high (pLDDT > 90) AlphaFold P61081 Q15843 B 44 I A mutation disrupting rate(MI:1129) Impact -0.41512 94 Very high (pLDDT > 90) AlphaFold P61081 Q15843 B 8 L A mutation decreasing rate(MI:1130) Impact -4.03373 78 Confident (90 > pLDDT > 70) AlphaFold P61081 Q15843 B 32 E D mutation decreasing rate(MI:1130) Impact -0.00925 90 Very high (pLDDT > 90) AlphaFold P61326 Q9Y5S9 B 118 L R mutation decreasing(MI:0119) Impact 4.2283 98 Very high (pLDDT > 90) AlphaFold P61956 P63279 B 17 R E mutation disrupting(MI:0573) Impact 4.79448 97.41 Very high (pLDDT > 90) AlphaFold P61956 P63279 B 20 H D mutation disrupting(MI:0573) Impact 3.03258 97.4 Very high (pLDDT > 90) AlphaFold P62805 P84243 B 91 G M mutation disrupting strength(MI:1128) Impact -0.9045 96.28 Very high (pLDDT > 90) AlphaFold P62805 P84243 B 91 G D mutation disrupting strength(MI:1128) Impact -0.3841 96.28 Very high (pLDDT > 90) AlphaFold P62805 P84243 B 91 G V mutation disrupting strength(MI:1128) Impact -0.3874 96.28 Very high (pLDDT > 90) AlphaFold P62805 P84243 B 91 G L mutation disrupting strength(MI:1128) Impact -0.7156 96.28 Very high (pLDDT > 90) AlphaFold P62805 P84243 B 58 S A mutation disrupting strength(MI:1128) Impact 0.0081 92.82 Very high (pLDDT > 90) AlphaFold P62805 P84243 B 94 Q A mutation disrupting strength(MI:1128) Impact -0.0419 96.78 Very high (pLDDT > 90) AlphaFold P62805 P84243 B 95 E A mutation disrupting strength(MI:1128) Impact 0.4885 96.41 Very high (pLDDT > 90) AlphaFold P63272 O00267 B 194 I V mutation with no effect(MI:2226) Neutral 0.8455 95.32 Very high (pLDDT > 90) AlphaFold P78364 P35227 B 180 F D mutation decreasing strength(MI:1133) Impact 4.0409 94 Very high (pLDDT > 90) AlphaFold P78364 P35227 B 165 F A mutation decreasing strength(MI:1133) Impact 1.9731 93 Very high (pLDDT > 90) AlphaFold P78364 P35227 B 164 R A mutation decreasing strength(MI:1133) Impact 0.6526 90 Very high (pLDDT > 90) AlphaFold Q03518 Q03519 B 602 E C mutation(MI:0118) Neutral -1.231 65 Low (70 > pLDDT > 50) AlphaFold Q12769 Q9BW27 B 645 R W mutation decreasing strength(MI:1133) Impact 0.4406 85 Confident (90 > pLDDT > 70) AlphaFold Q12769 Q9BW27 B 645 R W mutation decreasing strength(MI:1133) Impact 0.4406 85 Confident (90 > pLDDT > 70) AlphaFold Q13153 O43639 B 125 E K mutation with no effect(MI:2226) Neutral -0.2749 74 Confident (90 > pLDDT > 70) AlphaFold Q13418 P48059 B 66 L D mutation decreasing(MI:0119) Impact 0.210863 64 Low (70 > pLDDT > 50) AlphaFold Q13418 P48059 B 62 D A mutation decreasing(MI:0119) Impact 0.064341 73 Confident (90 > pLDDT > 70) AlphaFold Q13637 P57729 B 69 Q L mutation(MI:0118) Neutral -0.0053 67 Low (70 > pLDDT > 50) AlphaFold Q13637 P57729 B 69 Q L mutation(MI:0118) Neutral -0.0053 67 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 446 T E mutation with no effect(MI:2226) Neutral -0.0136 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 446 T K mutation with no effect(MI:2226) Neutral -0.1847 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 446 T A mutation with no effect(MI:2226) Neutral -7e-4 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 576 P E mutation with no effect(MI:2226) Neutral 0.6836 78 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 576 P A mutation with no effect(MI:2226) Neutral 1.4946 78 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 576 P K mutation disrupting strength(MI:1128) Impact 3.4816 78 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 581 H A mutation with no effect(MI:2226) Neutral -0.4574 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 581 H E mutation with no effect(MI:2226) Neutral 0.0656 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 581 H K mutation with no effect(MI:2226) Neutral -0.0652 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 535 F A mutation with no effect(MI:2226) Neutral 0.441 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 535 F K mutation with no effect(MI:2226) Neutral 0.3115 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 535 F E mutation with no effect(MI:2226) Neutral 0.9845 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 504 H E mutation with no effect(MI:2226) Neutral 0.3356 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 504 H A mutation with no effect(MI:2226) Neutral 0.2136 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 504 H K mutation with no effect(MI:2226) Neutral -0.0037 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 501 L K mutation disrupting strength(MI:1128) Impact -0.0034 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 501 L A mutation disrupting strength(MI:1128) Impact 0 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 501 L K mutation disrupting strength(MI:1128) Impact -0.0034 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 501 L E mutation disrupting strength(MI:1128) Impact -0.0236 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 501 L K mutation disrupting strength(MI:1128) Impact -0.0034 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 492 V K mutation with no effect(MI:2226) Neutral 0.0084 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 492 V A mutation with no effect(MI:2226) Neutral 0 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 492 V E mutation with no effect(MI:2226) Neutral 0.0267 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 502 T A mutation with no effect(MI:2226) Neutral 0.1526 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 502 T K mutation with no effect(MI:2226) Neutral -0.1919 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 502 T E mutation with no effect(MI:2226) Neutral 0.7651 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 441 E A mutation with no effect(MI:2226) Neutral 0.0195 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 441 E K mutation with no effect(MI:2226) Neutral 0.0317 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 592 A K mutation with no effect(MI:2226) Neutral -0.0567 28 Very low (pLDDT < 50) AlphaFold Q3SYG4 Q8NFJ9 B 592 A E mutation with no effect(MI:2226) Neutral -0.1652 28 Very low (pLDDT < 50) AlphaFold Q3SYG4 Q8NFJ9 B 447 A K mutation with no effect(MI:2226) Neutral -0.1238 70 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 447 A E mutation with no effect(MI:2226) Neutral 0.0742 70 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 573 Q E mutation with no effect(MI:2226) Neutral 0.0209 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 573 Q K mutation with no effect(MI:2226) Neutral -0.3469 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 573 Q A mutation with no effect(MI:2226) Neutral -0.3147 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 575 A K mutation with no effect(MI:2226) Neutral 0.1143 76 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 575 A E mutation with no effect(MI:2226) Neutral -1.8344 76 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 591 A K mutation with no effect(MI:2226) Neutral -0.0605 37 Very low (pLDDT < 50) AlphaFold Q3SYG4 Q8NFJ9 B 591 A E mutation with no effect(MI:2226) Neutral -0.0208 37 Very low (pLDDT < 50) AlphaFold Q3SYG4 Q8NFJ9 B 588 E K mutation with no effect(MI:2226) Neutral 0.0976 67 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 588 E A mutation with no effect(MI:2226) Neutral 0.0966 67 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 589 G K mutation with no effect(MI:2226) Neutral 0.0011 53 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 589 G E mutation with no effect(MI:2226) Neutral -0.0328 53 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 589 G A mutation with no effect(MI:2226) Neutral -6e-4 53 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 514 V E mutation with no effect(MI:2226) Neutral -0.2358 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 514 V A mutation with no effect(MI:2226) Neutral -0.5745 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 514 V K mutation with no effect(MI:2226) Neutral -0.3721 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 590 L K mutation with no effect(MI:2226) Neutral 0.0303 46 Very low (pLDDT < 50) AlphaFold Q3SYG4 Q8NFJ9 B 590 L A mutation with no effect(MI:2226) Neutral 0 46 Very low (pLDDT < 50) AlphaFold Q3SYG4 Q8NFJ9 B 590 L E mutation with no effect(MI:2226) Neutral -0.0356 46 Very low (pLDDT < 50) AlphaFold Q3SYG4 Q8NFJ9 B 500 K E mutation with no effect(MI:2226) Neutral 1.1949 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 500 K A mutation with no effect(MI:2226) Neutral 0.4638 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 493 Q A mutation with no effect(MI:2226) Neutral 0.0288 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 493 Q E mutation with no effect(MI:2226) Neutral 0.2623 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 493 Q K mutation with no effect(MI:2226) Neutral -0.2589 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 495 L A mutation with no effect(MI:2226) Neutral -0.0262 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 495 L E mutation with no effect(MI:2226) Neutral -0.3039 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 495 L K mutation with no effect(MI:2226) Neutral 0.0596 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 533 A E mutation with no effect(MI:2226) Neutral 0.7266 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 533 A K mutation with no effect(MI:2226) Neutral 0.746 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 448 M E mutation with no effect(MI:2226) Neutral -0.0211 66 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 448 M A mutation with no effect(MI:2226) Neutral 0.0091 66 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 448 M K mutation with no effect(MI:2226) Neutral -0.0092 66 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 503 L K mutation disrupting strength(MI:1128) Impact -0.0264 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 503 L E mutation disrupting strength(MI:1128) Impact 0.0857 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 503 L H mutation disrupting strength(MI:1128) Impact 0.0219 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 503 L A mutation with no effect(MI:2226) Neutral 0.0195 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 503 L E mutation disrupting strength(MI:1128) Impact 0.0857 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 503 L H mutation disrupting strength(MI:1128) Impact 0.0219 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 503 L E mutation disrupting strength(MI:1128) Impact 0.0857 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 572 G A mutation with no effect(MI:2226) Neutral 0.0598 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 572 G K mutation with no effect(MI:2226) Neutral -0.0193 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 572 G E mutation with no effect(MI:2226) Neutral 0.209 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 579 S E mutation with no effect(MI:2226) Neutral -0.4107 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 579 S K mutation with no effect(MI:2226) Neutral 0.1361 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 579 S A mutation with no effect(MI:2226) Neutral 0.4698 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 536 K E mutation with no effect(MI:2226) Neutral 1.4964 84 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 536 K A mutation with no effect(MI:2226) Neutral 1.2012 84 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 512 R A mutation with no effect(MI:2226) Neutral 0.0971 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 512 R H mutation with no effect(MI:2226) Neutral 0.808 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 512 R H mutation with no effect(MI:2226) Neutral 0.808 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 512 R E mutation with no effect(MI:2226) Neutral -0.572 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 512 R K mutation with no effect(MI:2226) Neutral -0.0309 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 470 A K mutation with no effect(MI:2226) Neutral -0.0362 66 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 470 A E mutation with no effect(MI:2226) Neutral 0.0205 66 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 555 L K mutation with no effect(MI:2226) Neutral -0.0394 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 555 L A mutation with no effect(MI:2226) Neutral 0.0365 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 555 L E mutation with no effect(MI:2226) Neutral 0.0995 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 475 L A mutation with no effect(MI:2226) Neutral 0.001 57 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 475 L K mutation with no effect(MI:2226) Neutral -0.0407 57 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 475 L E mutation with no effect(MI:2226) Neutral 0.0392 57 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 491 V A mutation with no effect(MI:2226) Neutral 0 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 491 V E mutation with no effect(MI:2226) Neutral 0.1714 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 491 V K mutation with no effect(MI:2226) Neutral -0.3094 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 490 A K mutation with no effect(MI:2226) Neutral 7e-4 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 490 A E mutation with no effect(MI:2226) Neutral 0.0197 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 534 F E mutation with no effect(MI:2226) Neutral 2.6376 82 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 534 F A mutation with no effect(MI:2226) Neutral 2.9981 82 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 534 F K mutation with no effect(MI:2226) Neutral 1.4098 82 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 532 R E mutation with no effect(MI:2226) Neutral 1.1953 76 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 532 R A mutation with no effect(MI:2226) Neutral 0.5443 76 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 532 R K mutation with no effect(MI:2226) Neutral 0.3517 76 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 580 A K mutation with no effect(MI:2226) Neutral 0 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 580 A E mutation with no effect(MI:2226) Neutral 0 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 578 L E mutation with no effect(MI:2226) Neutral -0.0297 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 578 L K mutation with no effect(MI:2226) Neutral -0.0306 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 578 L A mutation with no effect(MI:2226) Neutral 0.0407 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 523 Y E mutation disrupting strength(MI:1128) Impact 0.4415 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 523 Y K mutation with no effect(MI:2226) Neutral -0.2919 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 523 Y A mutation disrupting strength(MI:1128) Impact -0.1355 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 523 Y A mutation disrupting strength(MI:1128) Impact -0.1355 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 523 Y A mutation disrupting strength(MI:1128) Impact -0.1355 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 507 N A mutation with no effect(MI:2226) Neutral -0.4782 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 507 N K mutation with no effect(MI:2226) Neutral -0.2145 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 507 N E mutation disrupting strength(MI:1128) Impact -0.1674 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 507 N E mutation with no effect(MI:2226) Neutral -0.1674 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 507 N E mutation with no effect(MI:2226) Neutral -0.1674 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 464 A E mutation with no effect(MI:2226) Neutral 1.0387 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 464 A K mutation with no effect(MI:2226) Neutral -0.7334 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 509 S L mutation disrupting strength(MI:1128) Impact 0.1327 82 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 509 S A mutation with no effect(MI:2226) Neutral 0.1087 82 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 509 S K mutation with no effect(MI:2226) Neutral 0.0793 82 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 509 S E mutation with no effect(MI:2226) Neutral -0.054 82 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 510 T E mutation with no effect(MI:2226) Neutral 0.0136 74 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 510 T A mutation with no effect(MI:2226) Neutral -0.0057 74 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 510 T K mutation with no effect(MI:2226) Neutral -0.0024 74 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 452 F C mutation disrupting strength(MI:1128) Impact -0.0568 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 452 F A mutation with no effect(MI:2226) Neutral -0.0431 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 452 F K mutation with no effect(MI:2226) Neutral -0.0226 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 452 F E mutation with no effect(MI:2226) Neutral -0.0507 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 550 T K mutation with no effect(MI:2226) Neutral 0.5109 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 550 T A mutation with no effect(MI:2226) Neutral 0.168 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 550 T E mutation with no effect(MI:2226) Neutral 0.5115 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 474 S E mutation with no effect(MI:2226) Neutral -1.2015 58 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 474 S K mutation with no effect(MI:2226) Neutral -1.0137 58 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 474 S A mutation with no effect(MI:2226) Neutral -0.1546 58 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 505 L K mutation disrupting strength(MI:1128) Impact 0.0144 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 505 L A mutation with no effect(MI:2226) Neutral 0.0521 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 505 L K mutation disrupting strength(MI:1128) Impact 0.0144 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 505 L P mutation disrupting strength(MI:1128) Impact -0.6406 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 505 L K mutation disrupting strength(MI:1128) Impact 0.0144 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 505 L E mutation disrupting strength(MI:1128) Impact 0.0272 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 489 H A mutation with no effect(MI:2226) Neutral 0 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 489 H K mutation with no effect(MI:2226) Neutral -0.0632 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 489 H E mutation with no effect(MI:2226) Neutral 0.0471 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 531 P A mutation with no effect(MI:2226) Neutral 0.0043 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 531 P E mutation with no effect(MI:2226) Neutral 0.482 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 531 P K mutation with no effect(MI:2226) Neutral -0.3715 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 440 R E mutation with no effect(MI:2226) Neutral -0.0794 70 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 440 R A mutation with no effect(MI:2226) Neutral -0.0433 70 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 440 R K mutation with no effect(MI:2226) Neutral -0.062 70 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 574 S A mutation with no effect(MI:2226) Neutral -0.6811 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 574 S A mutation with no effect(MI:2226) Neutral -0.6811 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 574 S A mutation with no effect(MI:2226) Neutral -0.6811 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 574 S K mutation with no effect(MI:2226) Neutral -1.587 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 574 S E mutation with no effect(MI:2226) Neutral -2.0575 79 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 570 R A mutation with no effect(MI:2226) Neutral -0.0694 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 570 R E mutation with no effect(MI:2226) Neutral 0.0525 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 570 R K mutation with no effect(MI:2226) Neutral 0.0578 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 467 Y A mutation with no effect(MI:2226) Neutral 0.6797 71 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 467 Y K mutation with no effect(MI:2226) Neutral -0.0312 71 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 467 Y E mutation with no effect(MI:2226) Neutral 0.5934 71 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 466 A E mutation with no effect(MI:2226) Neutral 0.0351 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 466 A K mutation with no effect(MI:2226) Neutral -0.0015 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 468 L A mutation with no effect(MI:2226) Neutral 1.9655 74 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 468 L E mutation with no effect(MI:2226) Neutral 2.6145 74 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 468 L K mutation with no effect(MI:2226) Neutral 0.445 74 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 469 Q E mutation with no effect(MI:2226) Neutral 0.1117 70 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 469 Q A mutation with no effect(MI:2226) Neutral 0.0107 70 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 469 Q K mutation with no effect(MI:2226) Neutral -0.2565 70 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 547 P A mutation with no effect(MI:2226) Neutral 1.2102 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 547 P E mutation with no effect(MI:2226) Neutral 3.0881 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 547 P K mutation with no effect(MI:2226) Neutral -0.1262 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 513 P E mutation with no effect(MI:2226) Neutral 3.5783 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 513 P A mutation with no effect(MI:2226) Neutral 1.4354 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 513 P K mutation with no effect(MI:2226) Neutral 3.5284 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 537 V E mutation disrupting strength(MI:1128) Impact -0.2552 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 537 V A mutation with no effect(MI:2226) Neutral 0.1095 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 537 V E mutation disrupting strength(MI:1128) Impact -0.2552 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 537 V E mutation disrupting strength(MI:1128) Impact -0.2552 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 537 V K mutation disrupting strength(MI:1128) Impact 0.857 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 476 S A mutation with no effect(MI:2226) Neutral 0 59 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 476 S E mutation with no effect(MI:2226) Neutral 0.0106 59 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 476 S K mutation with no effect(MI:2226) Neutral -0.0062 59 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 484 E A mutation with no effect(MI:2226) Neutral -0.2205 74 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 484 E K mutation with no effect(MI:2226) Neutral -0.5341 74 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 482 A E mutation with no effect(MI:2226) Neutral 0.0962 60 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 482 A K mutation with no effect(MI:2226) Neutral -0.5282 60 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 437 Q E mutation with no effect(MI:2226) Neutral -0.0811 67 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 437 Q A mutation with no effect(MI:2226) Neutral 0.0085 67 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 437 Q K mutation with no effect(MI:2226) Neutral 0.0468 67 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 577 L A mutation with no effect(MI:2226) Neutral 0.1263 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 577 L E mutation with no effect(MI:2226) Neutral -0.1142 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 577 L K mutation with no effect(MI:2226) Neutral 0.0125 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 449 H A mutation with no effect(MI:2226) Neutral 3e-4 72 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 449 H E mutation with no effect(MI:2226) Neutral 0.0249 72 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 449 H K mutation with no effect(MI:2226) Neutral -0.0322 72 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 520 C E mutation with no effect(MI:2226) Neutral -0.0204 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 520 C K mutation with no effect(MI:2226) Neutral 0.3908 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 520 C A mutation with no effect(MI:2226) Neutral 0.057 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 567 L A mutation with no effect(MI:2226) Neutral 0.8969 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 567 L E mutation with no effect(MI:2226) Neutral 1.1887 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 567 L K mutation with no effect(MI:2226) Neutral 2.0112 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 450 R E mutation with no effect(MI:2226) Neutral 1.2254 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 450 R A mutation with no effect(MI:2226) Neutral 1.0791 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 450 R K mutation with no effect(MI:2226) Neutral 0.4001 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 451 A K mutation with no effect(MI:2226) Neutral -0.1169 71 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 451 A E mutation with no effect(MI:2226) Neutral 0.1383 71 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 463 A E mutation disrupting strength(MI:1128) Impact 0.0428 81 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 463 A K mutation disrupting strength(MI:1128) Impact -0.0217 81 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 551 F A mutation with no effect(MI:2226) Neutral 0.0068 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 551 F K mutation with no effect(MI:2226) Neutral -0.3509 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 551 F E mutation with no effect(MI:2226) Neutral 0.4159 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 549 E K mutation with no effect(MI:2226) Neutral -0.6191 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 549 E A mutation with no effect(MI:2226) Neutral -0.295 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 516 G A mutation disrupting strength(MI:1128) Impact -0.364 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 516 G A mutation disrupting strength(MI:1128) Impact -0.364 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 516 G E mutation with no effect(MI:2226) Neutral -0.1545 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 516 G K mutation with no effect(MI:2226) Neutral -0.9447 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 483 R A mutation with no effect(MI:2226) Neutral 0.6037 65 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 483 R E mutation with no effect(MI:2226) Neutral 0.9557 65 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 483 R K mutation with no effect(MI:2226) Neutral 0.383 65 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 481 T E mutation with no effect(MI:2226) Neutral 0.241 63 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 481 T K mutation with no effect(MI:2226) Neutral -0.5105 63 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 481 T A mutation with no effect(MI:2226) Neutral -0.0382 63 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 433 L K mutation with no effect(MI:2226) Neutral -0.0143 56 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 433 L E mutation with no effect(MI:2226) Neutral -0.0179 56 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 433 L A mutation with no effect(MI:2226) Neutral 0.0011 56 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 432 R K mutation with no effect(MI:2226) Neutral 0.0012 69 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 432 R L mutation disrupting strength(MI:1128) Impact 7e-4 69 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 432 R A mutation with no effect(MI:2226) Neutral 6e-4 69 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 432 R E mutation with no effect(MI:2226) Neutral 7e-4 69 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 522 L A mutation with no effect(MI:2226) Neutral 0.5027 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 522 L K mutation with no effect(MI:2226) Neutral 1.0854 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 522 L E mutation with no effect(MI:2226) Neutral -0.8858 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 569 L E mutation disrupting strength(MI:1128) Impact 1.5674 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 569 L A mutation with no effect(MI:2226) Neutral 1.3132 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 569 L K mutation with no effect(MI:2226) Neutral 0.818 85 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 521 F A mutation with no effect(MI:2226) Neutral -0.2884 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 521 F K mutation disrupting strength(MI:1128) Impact -0.0504 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 521 F K mutation disrupting strength(MI:1128) Impact -0.0504 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 521 F E mutation disrupting strength(MI:1128) Impact 0.2201 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 521 F K mutation disrupting strength(MI:1128) Impact -0.0504 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 544 L E mutation with no effect(MI:2226) Neutral 3.5029 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 544 L K mutation with no effect(MI:2226) Neutral 1.9525 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 544 L A mutation with no effect(MI:2226) Neutral 2.4023 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 543 G A mutation with no effect(MI:2226) Neutral 0.0967 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 543 G K mutation with no effect(MI:2226) Neutral -0.0991 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 543 G E mutation with no effect(MI:2226) Neutral -0.1301 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 542 P A mutation with no effect(MI:2226) Neutral 0.8652 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 542 P K mutation disrupting strength(MI:1128) Impact 0.9015 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 542 P E mutation with no effect(MI:2226) Neutral 2.5626 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 460 R A mutation with no effect(MI:2226) Neutral 0.5271 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 460 R E mutation with no effect(MI:2226) Neutral 1.0391 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 460 R K mutation with no effect(MI:2226) Neutral -0.0769 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 511 T E mutation with no effect(MI:2226) Neutral 0.1138 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 511 T A mutation with no effect(MI:2226) Neutral 0.0169 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 511 T K mutation with no effect(MI:2226) Neutral -0.1799 73 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 471 L A mutation with no effect(MI:2226) Neutral 0.251 65 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 471 L F mutation disrupting strength(MI:1128) Impact -0.1206 65 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 471 L E mutation with no effect(MI:2226) Neutral 0.2769 65 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 471 L K mutation with no effect(MI:2226) Neutral -0.15 65 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 473 S A mutation with no effect(MI:2226) Neutral 0.0225 60 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 473 S K mutation with no effect(MI:2226) Neutral -0.0064 60 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 473 S E mutation with no effect(MI:2226) Neutral 0.2816 60 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 506 Q E mutation with no effect(MI:2226) Neutral -0.0199 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 506 Q A mutation with no effect(MI:2226) Neutral 0.0324 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 506 Q K mutation with no effect(MI:2226) Neutral 0.1719 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 436 D A mutation disrupting strength(MI:1128) Impact 0.0286 71 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 436 D K mutation with no effect(MI:2226) Neutral 0.031 71 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 436 D E mutation with no effect(MI:2226) Neutral 0.0206 71 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 571 E K mutation with no effect(MI:2226) Neutral -0.6931 82 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 571 E A mutation with no effect(MI:2226) Neutral -0.6482 82 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 527 L A mutation with no effect(MI:2226) Neutral 0 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 527 L K mutation with no effect(MI:2226) Neutral 0.0059 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 527 L E mutation with no effect(MI:2226) Neutral -0.1738 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 527 L P mutation disrupting strength(MI:1128) Impact -0.1459 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 568 V A mutation disrupting strength(MI:1128) Impact 0.0305 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 568 V E mutation disrupting strength(MI:1128) Impact -0.0052 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 568 V K mutation disrupting strength(MI:1128) Impact 0.0856 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 568 V K mutation disrupting strength(MI:1128) Impact 0.0856 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 568 V K mutation disrupting strength(MI:1128) Impact 0.0856 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 515 L E mutation with no effect(MI:2226) Neutral 1.0872 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 515 L K mutation with no effect(MI:2226) Neutral -0.2167 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 515 L A mutation with no effect(MI:2226) Neutral 1.5296 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 465 R A mutation with no effect(MI:2226) Neutral 0.64 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 465 R K mutation with no effect(MI:2226) Neutral -0.111 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 465 R E mutation with no effect(MI:2226) Neutral 1.0087 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 546 Y E mutation disrupting strength(MI:1128) Impact 3.0817 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 546 Y K mutation disrupting strength(MI:1128) Impact 0.6965 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 546 Y K mutation disrupting strength(MI:1128) Impact 0.6965 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 546 Y A mutation with no effect(MI:2226) Neutral 2.3433 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 546 Y K mutation with no effect(MI:2226) Neutral 0.6965 91 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 518 L E mutation with no effect(MI:2226) Neutral 0.6897 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 518 L K mutation with no effect(MI:2226) Neutral 0.1591 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 518 L P mutation disrupting strength(MI:1128) Impact 0.5222 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 518 L A mutation with no effect(MI:2226) Neutral 0.4706 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 461 L A mutation with no effect(MI:2226) Neutral 2.1939 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 461 L E mutation with no effect(MI:2226) Neutral 2.3701 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 461 L K mutation with no effect(MI:2226) Neutral 1.5213 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 548 L K mutation with no effect(MI:2226) Neutral 0.2077 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 548 L A mutation with no effect(MI:2226) Neutral 0.4171 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 548 L E mutation with no effect(MI:2226) Neutral 0.7964 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 548 L E mutation disrupting strength(MI:1128) Impact 0.7964 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 548 L E mutation disrupting strength(MI:1128) Impact 0.7964 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 453 Q E mutation with no effect(MI:2226) Neutral 0.1093 78 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 453 Q K mutation with no effect(MI:2226) Neutral -0.1619 78 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 453 Q A mutation with no effect(MI:2226) Neutral 0.053 78 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 539 L E mutation disrupting strength(MI:1128) Impact 3.1516 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 539 L A mutation disrupting strength(MI:1128) Impact 1.7805 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 539 L K mutation disrupting strength(MI:1128) Impact 0.8656 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 539 L K mutation disrupting strength(MI:1128) Impact 0.8656 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 539 L K mutation disrupting strength(MI:1128) Impact 0.8656 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 530 L K mutation disrupting strength(MI:1128) Impact -0.0259 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 530 L E mutation disrupting strength(MI:1128) Impact 0.3067 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 530 L D mutation disrupting strength(MI:1128) Impact 0.205 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 530 L Q mutation disrupting strength(MI:1128) Impact 0.0234 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 530 L E mutation disrupting strength(MI:1128) Impact 0.3067 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 530 L E mutation disrupting strength(MI:1128) Impact 0.3067 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 530 L N mutation disrupting strength(MI:1128) Impact -0.0415 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 530 L R mutation disrupting strength(MI:1128) Impact -0.0522 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 530 L A mutation disrupting strength(MI:1128) Impact -0.0338 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 530 L T mutation disrupting strength(MI:1128) Impact 0.0242 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 530 L V mutation disrupting strength(MI:1128) Impact 0.0213 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 528 Y A mutation disrupting strength(MI:1128) Impact -0.0018 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 528 Y K mutation disrupting strength(MI:1128) Impact -0.0155 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 528 Y E mutation disrupting strength(MI:1128) Impact -0.0167 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 528 Y C mutation disrupting strength(MI:1128) Impact -0.0117 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 421 Q E mutation with no effect(MI:2226) Neutral 0.0298 46 Very low (pLDDT < 50) AlphaFold Q3SYG4 Q8NFJ9 B 421 Q A mutation with no effect(MI:2226) Neutral 0 46 Very low (pLDDT < 50) AlphaFold Q3SYG4 Q8NFJ9 B 421 Q K mutation with no effect(MI:2226) Neutral -0.0454 46 Very low (pLDDT < 50) AlphaFold Q3SYG4 Q8NFJ9 B 562 D A mutation with no effect(MI:2226) Neutral 0.0233 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 562 D K mutation with no effect(MI:2226) Neutral 0.0189 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 562 D E mutation with no effect(MI:2226) Neutral 0.019 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 541 V A mutation with no effect(MI:2226) Neutral 1.8121 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 541 V K mutation with no effect(MI:2226) Neutral 1.2097 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 541 V E mutation with no effect(MI:2226) Neutral 2.2825 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 519 V E mutation disrupting strength(MI:1128) Impact 0.1198 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 519 V A mutation with no effect(MI:2226) Neutral 0.1092 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 519 V K mutation disrupting strength(MI:1128) Impact -0.5947 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 519 V K mutation disrupting strength(MI:1128) Impact -0.5947 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 519 V K mutation disrupting strength(MI:1128) Impact -0.5947 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 462 R A mutation with no effect(MI:2226) Neutral 0.0164 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 462 R E mutation with no effect(MI:2226) Neutral 0.0887 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 462 R K mutation with no effect(MI:2226) Neutral 0.0568 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 563 I K mutation with no effect(MI:2226) Neutral -0.0411 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 563 I E mutation with no effect(MI:2226) Neutral 0.0429 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 563 I A mutation with no effect(MI:2226) Neutral 0.0021 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 524 N E mutation with no effect(MI:2226) Neutral -0.3583 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 524 N A mutation disrupting strength(MI:1128) Impact 0.0162 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 524 N K mutation with no effect(MI:2226) Neutral 0.0081 86 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 459 L A mutation with no effect(MI:2226) Neutral -0.0113 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 459 L S mutation disrupting strength(MI:1128) Impact -0.002 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 459 L K mutation with no effect(MI:2226) Neutral -0.0394 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 459 L E mutation with no effect(MI:2226) Neutral -0.0308 83 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 545 N E mutation with no effect(MI:2226) Neutral 0.5729 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 545 N K mutation with no effect(MI:2226) Neutral 0.2252 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 545 N A mutation with no effect(MI:2226) Neutral 0.3312 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 454 T E mutation with no effect(MI:2226) Neutral 0.4164 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 454 T K mutation with no effect(MI:2226) Neutral -0.0669 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 454 T A mutation with no effect(MI:2226) Neutral 0.6476 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 564 I E mutation disrupting strength(MI:1128) Impact -0.3392 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 564 I K mutation disrupting strength(MI:1128) Impact -0.3163 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 564 I A mutation with no effect(MI:2226) Neutral -0.0336 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 564 I A mutation disrupting strength(MI:1128) Impact -0.0336 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 564 I A mutation with no effect(MI:2226) Neutral -0.0336 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 529 S K mutation with no effect(MI:2226) Neutral -0.0501 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 529 S A mutation with no effect(MI:2226) Neutral 0 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 529 S E mutation with no effect(MI:2226) Neutral 0.2502 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 480 T A mutation with no effect(MI:2226) Neutral 0.2379 59 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 480 T K mutation with no effect(MI:2226) Neutral 0.5888 59 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 480 T A mutation with no effect(MI:2226) Neutral 0.2379 59 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 480 T A mutation with no effect(MI:2226) Neutral 0.2379 59 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 480 T E mutation with no effect(MI:2226) Neutral 0.2445 59 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 455 D E mutation with no effect(MI:2226) Neutral 0.0589 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 455 D A mutation with no effect(MI:2226) Neutral 0.0405 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 455 D K mutation with no effect(MI:2226) Neutral 0.048 75 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 566 V E mutation disrupting strength(MI:1128) Impact -0.0509 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 566 V A mutation with no effect(MI:2226) Neutral -0.017 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 566 V E mutation disrupting strength(MI:1128) Impact -0.0509 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 566 V K mutation disrupting strength(MI:1128) Impact -0.0263 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 566 V E mutation disrupting strength(MI:1128) Impact -0.0509 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 472 E A mutation with no effect(MI:2226) Neutral -0.1282 64 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 472 E K mutation with no effect(MI:2226) Neutral -0.1732 64 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 540 L K mutation disrupting strength(MI:1128) Impact -0.6944 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 540 L E mutation disrupting strength(MI:1128) Impact -0.101 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 540 L E mutation disrupting strength(MI:1128) Impact -0.101 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 540 L A mutation with no effect(MI:2226) Neutral -0.3187 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 540 L E mutation disrupting strength(MI:1128) Impact -0.101 90 Very high (pLDDT > 90) AlphaFold Q3SYG4 Q8NFJ9 B 526 A K mutation with no effect(MI:2226) Neutral -0.0123 84 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 526 A E mutation with no effect(MI:2226) Neutral -0.0207 84 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 456 L E mutation with no effect(MI:2226) Neutral 0.0567 81 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 456 L A mutation with no effect(MI:2226) Neutral -0.0069 81 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 456 L K mutation with no effect(MI:2226) Neutral -0.1552 81 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 478 L A mutation with no effect(MI:2226) Neutral 0 59 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 478 L E mutation with no effect(MI:2226) Neutral 0 59 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 478 L K mutation with no effect(MI:2226) Neutral 0 59 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 458 L E mutation with no effect(MI:2226) Neutral 0.9264 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 458 L A mutation with no effect(MI:2226) Neutral 1.3676 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 458 L K mutation with no effect(MI:2226) Neutral 0.5632 80 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 457 Y E mutation with no effect(MI:2226) Neutral 3.5418 81 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 457 Y K mutation with no effect(MI:2226) Neutral 2.097 81 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 457 Y A mutation with no effect(MI:2226) Neutral 3.1344 81 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 565 K A mutation with no effect(MI:2226) Neutral -0.1534 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 565 K E mutation with no effect(MI:2226) Neutral -0.041 88 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 525 E A mutation with no effect(MI:2226) Neutral 0.9342 81 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 525 E K mutation with no effect(MI:2226) Neutral 0.4184 81 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 479 S A mutation with no effect(MI:2226) Neutral 0.2722 62 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 479 S K mutation with no effect(MI:2226) Neutral -0.3803 62 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 479 S E mutation with no effect(MI:2226) Neutral -0.2739 62 Low (70 > pLDDT > 50) AlphaFold Q3SYG4 Q8NFJ9 B 538 P E mutation with no effect(MI:2226) Neutral 2.6411 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 538 P L mutation disrupting strength(MI:1128) Impact -0.4748 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 538 P A mutation with no effect(MI:2226) Neutral 1.1196 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 538 P K mutation with no effect(MI:2226) Neutral 1.4917 87 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 517 L E mutation disrupting strength(MI:1128) Impact 0.0253 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 517 L E mutation disrupting strength(MI:1128) Impact 0.0253 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 517 L K mutation disrupting strength(MI:1128) Impact -0.5615 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 517 L A mutation with no effect(MI:2226) Neutral -0.0343 89 Confident (90 > pLDDT > 70) AlphaFold Q3SYG4 Q8NFJ9 B 517 L E mutation disrupting strength(MI:1128) Impact 0.0253 89 Confident (90 > pLDDT > 70) AlphaFold Q5TA45 Q9NV88 B 644 R E mutation disrupting strength(MI:1128) Impact 2.758 89 Confident (90 > pLDDT > 70) AlphaFold Q5TA45 Q9NV88 B 644 R E mutation disrupting strength(MI:1128) Impact 2.758 89 Confident (90 > pLDDT > 70) AlphaFold Q68E01 Q9BQ15 B 98 F A mutation(MI:0118) Neutral 4.7475 95 Very high (pLDDT > 90) AlphaFold Q68E01 Q9BQ15 B 98 F A mutation disrupting strength(MI:1128) Impact 4.7475 95 Very high (pLDDT > 90) AlphaFold Q6ZW61 Q9NPJ1 B 57 T A mutation decreasing(MI:0119) Impact -0.834 89 Confident (90 > pLDDT > 70) AlphaFold Q6ZW61 Q9NPJ1 B 57 T A mutation decreasing(MI:0119) Impact -0.834 89 Confident (90 > pLDDT > 70) AlphaFold Q6ZW61 Q9NPJ1 B 57 T A mutation decreasing(MI:0119) Impact -0.834 89 Confident (90 > pLDDT > 70) AlphaFold Q6ZW61 Q9NPJ1 B 57 T A mutation disrupting strength(MI:1128) Impact -0.834 89 Confident (90 > pLDDT > 70) AlphaFold Q6ZW61 Q9NPJ1 B 57 T A mutation disrupting strength(MI:1128) Impact -0.834 89 Confident (90 > pLDDT > 70) AlphaFold Q86TG7 O95751 B 12 L H mutation with no effect(MI:2226) Neutral 2.0757 91 Very high (pLDDT > 90) AlphaFold Q86U86 Q12824 B 366 R C mutation(MI:0118) Neutral -0.03806 70 Confident (90 > pLDDT > 70) AlphaFold Q86U86 Q12824 B 363 K N mutation with no effect(MI:2226) Neutral -0.38199 77 Confident (90 > pLDDT > 70) AlphaFold Q86U86 Q12824 B 377 R C mutation(MI:0118) Neutral 0.06093 51 Low (70 > pLDDT > 50) AlphaFold Q86U86 Q12824 B 377 R C mutation(MI:0118) Neutral 0.06093 51 Low (70 > pLDDT > 50) AlphaFold Q8N4V1 Q15006 B 156 E A mutation disrupting strength(MI:1128) Impact 2.0717 95 Very high (pLDDT > 90) AlphaFold Q8N4V1 Q15006 B 160 E A mutation disrupting strength(MI:1128) Impact 0.0553 96 Very high (pLDDT > 90) AlphaFold Q8N4V1 Q15006 B 227 R A mutation disrupting strength(MI:1128) Impact 0.6128 93 Very high (pLDDT > 90) AlphaFold Q8N4V1 Q15006 B 28 R A mutation disrupting strength(MI:1128) Impact 1.2854 88 Confident (90 > pLDDT > 70) AlphaFold Q8WUM0 P57740 B 889 Y C mutation decreasing strength(MI:1133) Impact 0.2324 86 Confident (90 > pLDDT > 70) AlphaFold Q8WUM0 P57740 B 889 Y C mutation decreasing strength(MI:1133) Impact 0.2324 86 Confident (90 > pLDDT > 70) AlphaFold Q8WV22 Q96MG7 B 97 L A mutation disrupting strength(MI:1128) Impact 0.4789 91 Very high (pLDDT > 90) AlphaFold Q92785 Q12824 B 377 R C mutation(MI:0118) Neutral 0.40639 66 Low (70 > pLDDT > 50) AlphaFold Q92785 Q12824 B 377 R C mutation(MI:0118) Neutral 0.40639 66 Low (70 > pLDDT > 50) AlphaFold Q92785 Q12824 B 366 R C mutation(MI:0118) Neutral 0.01447 77 Confident (90 > pLDDT > 70) AlphaFold Q96B26 Q9NQT4 B 96 R Q mutation disrupting strength(MI:1128) Impact 0.1546 92 Very high (pLDDT > 90) AlphaFold Q96B26 Q9NQT4 B 78 V M mutation disrupting strength(MI:1128) Impact 0.0016 93 Very high (pLDDT > 90) AlphaFold Q96B26 Q9NQT4 B 178 R W mutation disrupting strength(MI:1128) Impact -0.3694 89 Confident (90 > pLDDT > 70) AlphaFold Q96BD8 Q8IX90 B 28 A V mutation with no effect(MI:2226) Neutral 0.0547 86 Confident (90 > pLDDT > 70) AlphaFold Q96BD8 Q8IX90 B 335 D E mutation with no effect(MI:2226) Neutral -0.086 51 Low (70 > pLDDT > 50) AlphaFold Q96QK1 O75436 B 238 G P mutation disrupting(MI:0573) Impact 12.48882 90 Very high (pLDDT > 90) AlphaFold Q99460 Q16186 B 104 R D mutation disrupting strength(MI:1128) Impact 1.013 82 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 104 R E mutation disrupting strength(MI:1128) Impact 1.5224 82 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 104 R E mutation decreasing strength(MI:1133) Impact 1.5224 82 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 104 R A mutation decreasing strength(MI:1133) Impact 0.6165 82 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 104 R D mutation decreasing strength(MI:1133) Impact 1.013 82 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 104 R A mutation decreasing strength(MI:1133) Impact 0.6165 82 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 97 K D mutation decreasing strength(MI:1133) Impact 0.6183 85 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 97 K D mutation disrupting strength(MI:1128) Impact 0.6183 85 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 97 K A mutation decreasing strength(MI:1133) Impact 0.6412 85 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 97 K A mutation decreasing strength(MI:1133) Impact 0.6412 85 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 97 K E mutation disrupting strength(MI:1128) Impact 0.7894 85 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 97 K E mutation decreasing strength(MI:1133) Impact 0.7894 85 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 83 K A mutation decreasing strength(MI:1133) Impact 0.3351 85 Confident (90 > pLDDT > 70) AlphaFold Q99460 Q16186 B 83 K A mutation with no effect(MI:2226) Neutral 0.3351 85 Confident (90 > pLDDT > 70) AlphaFold Q9BPX6 Q8IYU8 B 352 R E mutation disrupting strength(MI:1128) Impact 3.2277 84 Confident (90 > pLDDT > 70) AlphaFold Q9BSQ5 O00522 B 234 F A mutation with no effect(MI:2226) Neutral 1.3064 67 Low (70 > pLDDT > 50) AlphaFold Q9BSQ5 O00522 B 248 V D mutation disrupting strength(MI:1128) Impact 0.0474 25 Very low (pLDDT < 50) AlphaFold Q9BSQ5 O00522 B 244 V L mutation decreasing strength(MI:1133) Impact -0.6001 24 Very low (pLDDT < 50) AlphaFold Q9BUE0 Q9H944 B 50 A T mutation with no effect(MI:2226) Neutral 0 59 Low (70 > pLDDT > 50) AlphaFold Q9H074 P11940 B 567 F A mutation disrupting(MI:0573) Impact 1.4176 93 Very high (pLDDT > 90) AlphaFold Q9H074 P11940 B 580 K A mutation disrupting(MI:0573) Impact 0.7503 93 Very high (pLDDT > 90) AlphaFold Q9H0D6 Q96HQ2 B 81 Y A mutation disrupting strength(MI:1128) Impact 3.7548 92 Very high (pLDDT > 90) AlphaFold Q9H269 Q96AX1 B 438 Y D mutation disrupting(MI:0573) Impact 5.7665 92 Very high (pLDDT > 90) AlphaFold Q9H269 Q96AX1 B 438 Y P mutation disrupting strength(MI:1128) Impact 4.754 92 Very high (pLDDT > 90) AlphaFold Q9H269 Q96AX1 B 429 K D mutation disrupting(MI:0573) Impact 0.5324 96 Very high (pLDDT > 90) AlphaFold Q9H269 Q96AX1 B 441 I K mutation disrupting(MI:0573) Impact 3.8811 94 Very high (pLDDT > 90) AlphaFold Q9H6U6 Q9BSU1 B 13 G R mutation with no effect(MI:2226) Neutral 0.0501 91 Very high (pLDDT > 90) AlphaFold Q9NUU7 A9UHW6 B 160 E K mutation with no effect(MI:2226) Neutral 0.0411 96 Very high (pLDDT > 90) AlphaFold Q9NX24 Q9NPE3 B 34 R W mutation with no effect(MI:2226) Neutral -0.5508 70 Confident (90 > pLDDT > 70) AlphaFold Q9NX24 Q9NPE3 B 34 R W mutation with no effect(MI:2226) Neutral -0.5508 70 Confident (90 > pLDDT > 70) AlphaFold Q9NXX6 Q96MG7 B 266 F A mutation disrupting strength(MI:1128) Impact 1.4003 95 Very high (pLDDT > 90) AlphaFold Q9NXX6 Q96MG7 B 264 L F mutation disrupting strength(MI:1128) Impact -0.9044 95 Very high (pLDDT > 90) AlphaFold Q9NXX6 Q96MG7 B 209 P L mutation disrupting strength(MI:1128) Impact 0.088 92 Very high (pLDDT > 90) AlphaFold Q9NXX6 Q96MG7 B 97 L A mutation with no effect(MI:2226) Neutral 0.1288 94 Very high (pLDDT > 90) AlphaFold Q9NYB0 Q15554 B 330 L E mutation disrupting strength(MI:1128) Impact 3.2955 94 Very high (pLDDT > 90) AlphaFold Q9NYB0 Q15554 B 330 L R mutation disrupting strength(MI:1128) Impact 4.0853 94 Very high (pLDDT > 90) AlphaFold Q9NYB0 Q15554 B 330 L R mutation disrupting strength(MI:1128) Impact 4.0853 94 Very high (pLDDT > 90) AlphaFold Q9NYB0 Q15554 B 330 L R mutation disrupting strength(MI:1128) Impact 4.0853 94 Very high (pLDDT > 90) AlphaFold Q9P0I2 Q15006 B 227 R A mutation disrupting strength(MI:1128) Impact -0.0031 92 Very high (pLDDT > 90) AlphaFold Q9P0I2 Q15006 B 180 E A mutation disrupting strength(MI:1128) Impact 4.2189 96 Very high (pLDDT > 90) AlphaFold Q9P0I2 Q15006 B 259 W A mutation disrupting strength(MI:1128) Impact 3.1286 95 Very high (pLDDT > 90) AlphaFold Q9UHB7 Q03111 B 550 L E mutation disrupting(MI:0573) Impact -0.0376 94 Very high (pLDDT > 90) AlphaFold Q9UKX7 P52294 B 433 T M mutation with no effect(MI:2226) Neutral -2e-4 92 Very high (pLDDT > 90) AlphaFold Q9Y224 Q8NCA5 B 283 S G mutation with no effect(MI:2226) Neutral 0.147 59 Low (70 > pLDDT > 50) AlphaFold Q9Y294 P54198 B 461 I D mutation disrupting(MI:0573) Impact 3.7833 91 Very high (pLDDT > 90) AlphaFold Q9Y294 P54198 B 464 L D mutation disrupting(MI:0573) Impact 0.7538 81 Confident (90 > pLDDT > 70) AlphaFold Q9Y294 P54198 B 466 I D mutation disrupting strength(MI:1128) Impact 1.7223 68 Low (70 > pLDDT > 50) AlphaFold Q9Y294 P54198 B 460 R A mutation disrupting(MI:0573) Impact 1.2553 90 Very high (pLDDT > 90) AlphaFold Q9Y294 P54198 B 459 R A mutation disrupting(MI:0573) Impact 0.2005 91 Very high (pLDDT > 90) Experimental O95931 Q99496 A 234 F D mutation disrupting(MI:0573) Impact 6.39378 NA Experimental Experimental P01100 P05412 A 176 K N mutation disrupting strength(MI:1128) Impact 0.12335 NA Experimental Experimental P55072 Q9UNZ2 A 113 R A mutation decreasing strength(MI:1133) Impact 0.620999999999998 NA Experimental Experimental P60891 Q14558 A 43 E D mutation with no effect(MI:2226) Neutral 0.751399999999995 NA Experimental Experimental P60891 Q14558 A 114 N S mutation with no effect(MI:2226) Neutral 0.0401999999999987 NA Experimental Experimental P60891 Q14558 A 114 N S mutation with no effect(MI:2226) Neutral 0.0401999999999987 NA Experimental Experimental P61326 Q9BRP8 A 117 E R mutation decreasing(MI:0119) Impact 1.54014 NA Experimental Experimental P61326 Q9BRP8 A 117 E R mutation disrupting(MI:0573) Impact 1.54014 NA Experimental Experimental P61326 Q9BRP8 A 68 E R mutation disrupting(MI:0573) Impact 0.527860000000001 NA Experimental Experimental P61326 Q9BRP8 A 68 E R mutation decreasing(MI:0119) Impact 0.527860000000001 NA Experimental Experimental P61326 Q9Y5S9 A 136 L R mutation decreasing(MI:0119) Impact 7.4332988 NA Experimental Experimental P63279 Q9UBT2 A 93 C A mutation with no effect(MI:2226) Neutral -0.439219999999999 NA Experimental Experimental Q13418 Q9NVD7 A 223 K N mutation disrupting strength(MI:1128) Impact 1.1424 NA Experimental Experimental Q13418 Q9NVD7 A 349 R H mutation disrupting strength(MI:1128) Impact 4.39776 NA Experimental Experimental Q13418 Q9NVD7 A 362 Q H mutation with no effect(MI:2226) Neutral 0.592240000000007 NA Experimental Experimental Q86YP4 Q9UBB5 A 149 K R mutation decreasing(MI:0119) Impact 0.447 NA Experimental Experimental Q96B26 Q9NQT4 A 202 D V mutation disrupting strength(MI:1128) Impact 1.76199999999999 NA Experimental Experimental P11802 P42773 B 69 T A mutation with no effect(MI:2226) Neutral -0.353900000000004 NA Experimental Experimental P18754 P62826 B 70 E A mutation(MI:0118) Neutral 1.37754000000001 NA Experimental Experimental P26196 Q96F86 B 213 F L mutation disrupting strength(MI:1128) Impact 2.34804 NA Experimental Experimental P35249 P40937 B 131 T N mutation with no effect(MI:2226) Neutral -0.0104000000000099 NA Experimental Experimental P37198 Q7Z3B4 B 385 R K mutation with no effect(MI:2226) Neutral 0.4511962 NA Experimental Experimental P61081 Q15843 B 8 L A mutation decreasing rate(MI:1130) Impact 0.946759999999998 NA Experimental Experimental P61326 Q9Y5S9 B 118 L R mutation decreasing(MI:0119) Impact 7.9784177 NA Experimental Experimental Q68E01 Q9BQ15 B 98 F A mutation(MI:0118) Neutral 5.0898 NA Experimental Experimental Q68E01 Q9BQ15 B 98 F A mutation disrupting strength(MI:1128) Impact 5.0898 NA Experimental Experimental Q8WV22 Q96MG7 B 97 L A mutation disrupting strength(MI:1128) Impact 2.8296 NA Experimental Experimental Q96B26 Q9NQT4 B 96 R Q mutation disrupting strength(MI:1128) Impact 1.01360000000002 NA Experimental Experimental P00338 P07195 B 7 K E mutation with no effect(MI:2226) Neutral 0.143500000000002 NA Experimental Experimental P10644 P17612 B 206 L R mutation disrupting strength(MI:1128) Impact 5.50414 NA Experimental Experimental P10644 P17612 B 206 L R mutation disrupting strength(MI:1128) Impact 5.50414 NA Experimental Experimental P10644 P17612 B 206 L R mutation disrupting strength(MI:1128) Impact 5.50414 NA Experimental Experimental P11142 P34932 B 622 E A mutation decreasing(MI:0119) Impact 1.82160000000001 NA Experimental Experimental P11142 P34932 B 619 N Y mutation decreasing(MI:0119) Impact 0.244400000000007 NA Experimental Experimental P38919 P61326 B 20 E R mutation disrupting(MI:0573) Impact 5.27828 NA Experimental Experimental P15056 Q02750 B 314 L E mutation disrupting strength(MI:1128) Impact 5.032 NA Experimental Experimental P15056 Q02750 B 314 L E mutation disrupting rate(MI:1129) Impact 5.032 NA Experimental Experimental P15056 Q02750 B 310 I E mutation decreasing rate(MI:1130) Impact 2.31802 NA Experimental Experimental P15056 Q02750 B 310 I E mutation decreasing strength(MI:1133) Impact 2.31802 NA Experimental Experimental P15056 Q02750 B 228 S E mutation decreasing strength(MI:1133) Impact 8.55078 NA Experimental Experimental P15056 Q02750 B 228 S E mutation decreasing rate(MI:1130) Impact 8.55078 NA Experimental Experimental Q12874 Q15459 B 169 L K mutation disrupting(MI:0573) Impact 3.10176 NA Experimental Experimental Q96AX1 Q9H269 B 669 A D mutation decreasing(MI:0119) Impact 2.7632 NA Experimental Experimental Q96AX1 Q9H269 B 725 R E mutation disrupting(MI:0573) Impact 5.4914 NA Experimental Experimental Q15554 Q9NYB0 B 318 I R mutation disrupting(MI:0573) Impact 4.72654 NA Experimental Experimental Q15554 Q9NYB0 B 318 I R mutation disrupting(MI:0573) Impact 4.72654 NA Experimental Experimental Q15554 Q9NYB0 B 318 I R mutation disrupting(MI:0573) Impact 4.72654 NA Experimental Experimental Q15554 Q9NYB0 B 336 F R mutation disrupting(MI:0573) Impact 6.43136 NA Experimental Experimental Q15554 Q9NYB0 B 336 F R mutation disrupting(MI:0573) Impact 6.43136 NA Experimental Experimental Q15554 Q9NYB0 B 336 F R mutation disrupting(MI:0573) Impact 6.43136 NA Experimental Experimental Q96QK1 Q9UBQ0 B 92 P G mutation disrupting strength(MI:1128) Impact 3.85716 NA Experimental Experimental Q96QK1 Q9UBQ0 B 92 P A mutation disrupting strength(MI:1128) Impact 5.44173999999999 NA Experimental Experimental Q96QK1 Q9UBQ0 B 93 W A mutation disrupting strength(MI:1128) Impact 2.7876 NA Experimental Experimental Q96QK1 Q9UBQ0 B 93 W D mutation disrupting strength(MI:1128) Impact 3.2539 NA Experimental Experimental Q96QK1 Q9UBQ0 B 94 G P mutation disrupting strength(MI:1128) Impact 1.292 NA Experimental Experimental Q96QK1 Q9UBQ0 B 104 R D mutation disrupting strength(MI:1128) Impact 3.5098 NA Experimental Experimental Q9UBE0 Q9UBT2 B 85 P L mutation disrupting strength(MI:1128) Impact 2.109946 NA Experimental Experimental Q9BRT9 Q9Y248 B 150 L S mutation with no effect(MI:2226) Neutral 3.55434 NA Experimental Experimental Q9BRT9 Q9Y248 B 24 D G mutation with no effect(MI:2226) Neutral 0.964399999999997 NA Experimental Experimental Q9BRT9 Q9Y248 B 26 I T mutation with no effect(MI:2226) Neutral 2.95794 NA Experimental Experimental Q9BRT9 Q9Y248 B 172 T K mutation with no effect(MI:2226) Neutral 0.305420000000001 NA Experimental Experimental P54198 Q9Y294 B 37 D A mutation disrupting(MI:0573) Impact 0.611612 NA Experimental Experimental P54198 Q9Y294 B 37 D A mutation disrupting(MI:0573) Impact 0.611612 NA Experimental Experimental O00267 P63272 A 194 I V mutation with no effect(MI:2226) Neutral 1.34198 NA Experimental Experimental P48059 Q13418 A 66 L D mutation decreasing(MI:0119) Impact 4.47392 NA Experimental Experimental P48059 Q13418 A 62 D A mutation decreasing(MI:0119) Impact 0.085300000000001 NA Experimental Experimental P57740 Q8WUM0 A 889 Y C mutation decreasing strength(MI:1133) Impact 3.2795 NA Experimental Experimental P57740 Q8WUM0 A 889 Y C mutation decreasing strength(MI:1133) Impact 3.2795 NA Experimental Experimental Q8IX90 Q96BD8 A 28 A V mutation with no effect(MI:2226) Neutral 1.9507 NA Experimental Experimental Q96AX1 Q9H269 A 438 Y D mutation disrupting(MI:0573) Impact 5.0524 NA Experimental Experimental Q96AX1 Q9H269 A 438 Y P mutation disrupting strength(MI:1128) Impact 3.3102 NA Experimental Experimental Q96AX1 Q9H269 A 429 K D mutation disrupting(MI:0573) Impact 2.5514 NA Experimental Experimental Q96AX1 Q9H269 A 441 I K mutation disrupting(MI:0573) Impact 3.36 NA Experimental Experimental P52294 Q9UKX7 A 433 T M mutation with no effect(MI:2226) Neutral -0.48856 NA Experimental Experimental P54198 Q9Y294 A 461 I D mutation disrupting(MI:0573) Impact 6.360438 NA Experimental Experimental P54198 Q9Y294 A 464 L D mutation disrupting(MI:0573) Impact 1.443936 NA Experimental Experimental P54198 Q9Y294 A 466 I D mutation disrupting strength(MI:1128) Impact 1.919934 NA Experimental Experimental P54198 Q9Y294 A 460 R A mutation disrupting(MI:0573) Impact 2.395624 NA Experimental Experimental P54198 Q9Y294 A 459 R A mutation disrupting(MI:0573) Impact 1.34082 NA Experimental