{"text_format":"3","workbook":"xls","n_sheets":4,"sheets":["Sheet1","Sheet2","Sheet3","Sheet4"],"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"Sheet1","index":0,"n_rows":132,"n_cols":9,"rows_kept":132,"merged":[[0,0,0,8]],"flags":["formulas_cached_only"]}
["Gene Ontology (GO) results in molecular function"]
["ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID","Count"]
["GO:0004674","protein serine/threonine kinase activity","22/144","439/17697",{"v":8.76761938913702e-12,"d":"8.77E-12"},{"v":4.31366873945541e-09,"d":"4.31E-09"},{"v":2.9440743001418e-09,"d":"2.94E-09"},"BRAF/GSK3B/MAPK14/MAPK1/MAPK8/MAPK10/STK17B/PIK3CA/PIK3CG/PRKCB/MTOR/MAPK3/CLK2/AKT1/IKBKB/SGK1/AKT2/MAP3K9/TRPM6/PRKCZ/EIF2AK3/PRKAA2",22]
["GO:0004712","protein serine/threonine/tyrosine kinase activity","9/144","43/17697",{"v":5.41685569799854e-11,"d":"5.42E-11"},{"v":1.33254650170764e-08,"d":"1.33E-08"},{"v":9.09461561927124e-09,"d":"9.09E-09"},"MAPK14/MAPK1/MAPK10/MAPK3/CLK2/AKT1/SGK1/MAP3K9/PRKAA2",9]
["GO:0019902","phosphatase binding","14/144","185/17697",{"v":3.41990488958782e-10,"d":"3.42E-10"},{"v":5.60864401892403e-08,"d":"5.61E-08"},{"v":3.82789354308251e-08,"d":"3.83E-08"},"MAPK14/MAPK1/HMGCR/MAPK3/STAT3/KCNQ1/AKT1/PIK3R1/PTPN1/PPARG/PPARA/FOXO1/EIF2AK3/TP53",14]
["GO:0042562","hormone binding","11/144","102/17697",{"v":6.66455585501713e-10,"d":"6.66E-10"},{"v":8.19740370167107e-08,"d":"8.20E-08"},{"v":5.59471925723807e-08,"d":"5.59E-08"},"AR/IGF1R/MCHR1/INSR/PIK3R1/SHBG/VDR/AVPR1A/TTR/GCGR/MC4R",11]
["GO:0043560","insulin receptor substrate binding","5/144","11/17697",{"v":1.47778951840476e-08,"d":"1.48E-08"},{"v":1.32392106724489e-06,"d":"1.32E-06"},{"v":9.03574712133336e-07,"d":"9.04E-07"},"PIK3CA/IGF1R/INSR/PIK3R1/PRKCZ",5]
["GO:0003707","steroid hormone receptor activity","8/144","56/17697",{"v":1.61453788688402e-08,"d":"1.61E-08"},{"v":1.32392106724489e-06,"d":"1.32E-06"},{"v":9.03574712133336e-07,"d":"9.04E-07"},"AR/ESR1/VDR/PPARG/PPARA/HNF4A/RXRG/NR0B2",8]
["GO:0019903","protein phosphatase binding","11/144","140/17697",{"v":1.94992967714121e-08,"d":"1.95E-08"},{"v":1.37052200164782e-06,"d":"1.37E-06"},{"v":9.35379800012101e-07,"d":"9.35E-07"},"MAPK14/HMGCR/STAT3/KCNQ1/AKT1/PIK3R1/PTPN1/PPARG/FOXO1/EIF2AK3/TP53",11]
["GO:0033293","monocarboxylic acid binding","8/144","64/17697",{"v":4.76274866135074e-08,"d":"4.76E-08"},{"v":2.92909042673071e-06,"d":"2.93E-06"},{"v":1.99910108285643e-06,"d":"2.00E-06"},"VDR/PPARG/PPARA/FABP4/FABP2/HNF4A/CYP26B1/ACACB",8]
["GO:0031406","carboxylic acid binding","12/144","193/17697",{"v":5.9362842001625e-08,"d":"5.94E-08"},{"v":3.08922783470878e-06,"d":"3.09E-06"},{"v":2.10839469249487e-06,"d":"2.11E-06"},"NOS2/SELP/NOS3/VDR/PPARG/PPARA/FABP4/FABP2/HNF4A/CASR/CYP26B1/ACACB",12]
["GO:0004707","MAP kinase activity","5/144","14/17697",{"v":6.27891836322922e-08,"d":"6.28E-08"},{"v":3.08922783470878e-06,"d":"3.09E-06"},{"v":2.10839469249487e-06,"d":"2.11E-06"},"MAPK14/MAPK1/MAPK8/MAPK10/MAPK3",5]
["GO:0004879","nuclear receptor activity","7/144","47/17697",{"v":9.773659202441e-08,"d":"9.77E-08"},{"v":4.00720027300081e-06,"d":"4.01E-06"},{"v":2.73490989963042e-06,"d":"2.73E-06"},"AR/STAT3/ESR1/VDR/PPARG/PPARA/RXRG",7]
["GO:0098531","transcription factor activity, direct ligand regulated sequence-specific DNA binding","7/144","47/17697",{"v":9.773659202441e-08,"d":"9.77E-08"},{"v":4.00720027300081e-06,"d":"4.01E-06"},{"v":2.73490989963042e-06,"d":"2.73E-06"},"AR/STAT3/ESR1/VDR/PPARG/PPARA/RXRG",7]
["GO:0043177","organic acid binding","12/144","205/17697",{"v":1.15037575538159e-07,"d":"1.15E-07"},{"v":4.3537297819057e-06,"d":"4.35E-06"},{"v":2.97141591875892e-06,"d":"2.97E-06"},"NOS2/SELP/NOS3/VDR/PPARG/PPARA/FABP4/FABP2/HNF4A/CASR/CYP26B1/ACACB",12]
["GO:0004708","MAP kinase kinase activity","5/144","16/17697",{"v":1.35208978598803e-07,"d":"1.35E-07"},{"v":4.75162981932936e-06,"d":"4.75E-06"},{"v":3.24298226864798e-06,"d":"3.24E-06"},"MAPK14/MAPK1/MAPK10/MAPK3/MAP3K9",5]
["GO:0001085","RNA polymerase II transcription factor binding","10/144","155/17697",{"v":5.58229365489008e-07,"d":"5.58E-07"},{"v":1.83099231880395e-05,"d":"1.83E-05"},{"v":1.24965029888416e-05,"d":"1.25E-05"},"AR/GSK3B/STAT3/ESR1/PPARG/PPARA/FOS/HNF4A/TP53/NFE2L2",10]
["GO:0005536","glucose binding","4/144","11/17697",{"v":1.32732104880003e-06,"d":"1.33E-06"},{"v":4.0815122250601e-05,"d":"4.08E-05"},{"v":2.78562772741586e-05,"d":"2.79E-05"},"GCK/HK2/HK1/GYS1",4]
["GO:0017046","peptide hormone binding","6/144","49/17697",{"v":2.74100673813681e-06,"d":"2.74E-06"},{"v":7.93279597154888e-05,"d":"7.93E-05"},{"v":5.41412476449314e-05,"d":"5.41E-05"},"IGF1R/INSR/PIK3R1/AVPR1A/GCGR/MC4R",6]
["GO:0042277","peptide binding","12/144","295/17697",{"v":5.38428582650124e-06,"d":"5.38E-06"},0.00014535121477183,{"v":9.92020485926695e-05,"d":"9.92E-05"},"TLR4/BACE2/IGF1R/MCHR1/INSR/PIK3R1/PPARG/LNPEP/AVPR1A/GCGR/ADRB2/MC4R",12]
["GO:0051721","protein phosphatase 2A binding","5/144","32/17697",{"v":5.61315666801782e-06,"d":"5.61E-06"},0.00014535121477183,{"v":9.92020485926695e-05,"d":"9.92E-05"},"HMGCR/AKT1/PTPN1/FOXO1/TP53",5]
["GO:0033218","amide binding","13/144","356/17697",{"v":6.97200242565052e-06,"d":"6.97E-06"},0.000171511259671003,0.000117056251251711,"TLR4/BACE2/IGF1R/MCHR1/INSR/PIK3R1/PPARG/LNPEP/AVPR1A/GCGR/ADRB2/MC4R/ACACB",13]
["GO:0005504","fatty acid binding","5/144","34/17697",{"v":7.65528022384186e-06,"d":"7.66E-06"},0.000179352279530009,0.000122407738917572,"PPARG/PPARA/FABP4/FABP2/HNF4A",5]
["GO:0005496","steroid binding","7/144","95/17697",{"v":1.24067655572605e-05,"d":"1.24E-05"},0.000277460393371463,0.00018936642166345,"AR/HSD11B1/SHBG/ESR1/VDR/CYP3A4/CETP",7]
["GO:0070851","growth factor receptor binding","8/144","134/17697",{"v":1.38980675411088e-05,"d":"1.39E-05"},0.000297297792618501,0.000202905425428545,"TLR9/YES1/IL2/VEGFA/FGF2/IL6/PGF/IL1B",8]
["GO:0005355","glucose transmembrane transporter activity","4/144","20/17697",{"v":1.84075135038073e-05,"d":"1.84E-05"},0.000362259865754928,0.000247241970851139,"SLC5A2/SLC2A1/SLC5A1/SLC5A4",4]
["GO:0015149","hexose transmembrane transporter activity","4/144","20/17697",{"v":1.84075135038073e-05,"d":"1.84E-05"},0.000362259865754928,0.000247241970851139,"SLC5A2/SLC2A1/SLC5A1/SLC5A4",4]
["GO:0051427","hormone receptor binding","9/144","185/17697",{"v":2.07715411408118e-05,"d":"2.08E-05"},0.000393061470818438,0.000268264033357042,"PRKCB/STAT3/ESR1/VDR/PPARG/FABP4/SIRT1/HIF1A/NR0B2",9]
["GO:0017171","serine hydrolase activity","9/144","186/17697",{"v":2.16784902998038e-05,"d":"2.17E-05"},0.000395030267685314,0.00026960773511257,"MMP9/F2/MMP2/PLAT/PCSK7/ACE/DPP4/LIPE/CTRB1",9]
["GO:0015145","monosaccharide transmembrane transporter activity","4/144","22/17697",{"v":2.74422748990337e-05,"d":"2.74E-05"},0.000482199973225878,0.000329100965894427,"SLC5A2/SLC2A1/SLC5A1/SLC5A4",4]
["GO:0035257","nuclear hormone receptor binding","8/144","152/17697",{"v":3.45707644190657e-05,"d":"3.46E-05"},0.000586510899799322,0.000400293061694445,"PRKCB/STAT3/ESR1/VDR/PPARG/SIRT1/HIF1A/NR0B2",8]
["GO:0051119","sugar transmembrane transporter activity","4/144","24/17697",{"v":3.93624862832968e-05,"d":"3.94E-05"},0.000645544775046067,0.000440583618399006,"SLC5A2/SLC2A1/SLC5A1/SLC5A4",4]
["GO:0016705","oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen","8/144","159/17697",{"v":4.76502126682639e-05,"d":"4.77E-05"},0.000756254988154382,0.000516143220413453,"NOS2/PTGS2/CYP19A1/NOS3/CYP3A4/HMOX1/CYP26B1/FTO",8]
["GO:0051219","phosphoprotein binding","6/144","83/17697",{"v":5.8973289267945e-05,"d":"5.90E-05"},0.000906714322494654,0.000618831555147186,"MAPK1/MTOR/MAPK3/YES1/PIK3R1/PLAT",6]
["GO:0050661","NADP binding","5/144","52/17697",{"v":6.35692735725631e-05,"d":"6.36E-05"},0.000947760078718214,0.000646845239861169,"NOS2/HMGCR/NOS3/GAPDH/GSR",5]
["GO:0030246","carbohydrate binding","10/144","271/17697",{"v":7.61638631530466e-05,"d":"7.62E-05"},0.00110213590209703,0.000752206574174052,"SELP/GCK/HK2/HK1/IL2/MGAM/SORD/GYS1/SI/SELL",10]
["GO:0002020","protease binding","7/144","128/17697",{"v":8.49316616928932e-05,"d":"8.49E-05"},0.00119389650151153,0.000814833085113773,"GSK3B/CASP3/TNF/SERPINE1/DPP4/TP53/SELL",7]
["GO:0005539","glycosaminoglycan binding","9/144","229/17697",0.000108932815539766,0.00146104992510247,0.000997165010927872,"FGFR1/SELP/F2/HK1/SHH/VEGFA/FGF2/PGF/SELL",9]
["GO:0031994","insulin-like growth factor I binding","3/144","12/17697",0.000109998627297946,0.00146104992510247,0.000997165010927872,"IGF1R/INSR/IGFBP3",3]
["GO:0004713","protein tyrosine kinase activity","7/144","134/17697",0.000113256901147717,0.00146104992510247,0.000997165010927872,"FLT1/FGFR1/IGF1R/INSR/BLK/CLK2/YES1",7]
["GO:0020037","heme binding","7/144","135/17697",0.000118648201947427,0.00146104992510247,0.000997165010927872,"NOS2/PTGS2/CYP19A1/NOS3/CYP3A4/HMOX1/CYP26B1",7]
["GO:0005126","cytokine receptor binding","10/144","286/17697",0.000118784546756298,0.00146104992510247,0.000997165010927872,"TLR9/STAT3/PIK3R1/CASP3/IL2/TNF/VEGFA/IL6/PGF/IL1B",10]
["GO:0008236","serine-type peptidase activity","8/144","182/17697",0.000122862982020046,0.00147435578424056,0.00100624624555571,"MMP9/F2/MMP2/PLAT/PCSK7/ACE/DPP4/CTRB1",8]
["GO:0036041","long-chain fatty acid binding","3/144","14/17697",0.000179836135592163,0.00210665187407962,0.00143778765047368,"PPARG/FABP4/FABP2",3]
["GO:0046906","tetrapyrrole binding","7/144","145/17697",0.000184947877836345,0.00211614781152283,0.00144426861762041,"NOS2/PTGS2/CYP19A1/NOS3/CYP3A4/HMOX1/CYP26B1",7]
["GO:0008528","G protein-coupled peptide receptor activity","7/144","146/17697",0.000192957962652582,0.00215762085511524,0.00147257392550655,"MCHR1/AVPR2/AVPR1A/GCGR/AGTR1/CCR5/MC4R",7]
["GO:0002039","p53 binding","5/144","66/17697",0.000199532635091113,0.0021815568103295,0.00148891018933485,"GSK3B/SIRT1/SETD7/HIF1A/TP53",5]
["GO:0030374","nuclear receptor transcription coactivator activity","5/144","67/17697",0.000214225060486092,0.00229127673389473,0.0015637939197955,"PRKCB/VDR/PPARG/PPARA/FGF2",5]
["GO:0015144","carbohydrate transmembrane transporter activity","4/144","37/17697",0.000225376809847502,0.00235926362648875,0.00161019490126211,"SLC5A2/SLC2A1/SLC5A1/SLC5A4",4]
["GO:0001653","peptide receptor activity","7/144","152/17697",0.000247112460310916,0.00253290271818689,0.0017287033955961,"MCHR1/AVPR2/AVPR1A/GCGR/AGTR1/CCR5/MC4R",7]
["GO:0005159","insulin-like growth factor receptor binding","3/144","16/17697",0.000273387326829463,0.00274503193469583,0.00187348135893875,"REN/INSR/PIK3R1",3]
["GO:0001784","phosphotyrosine residue binding","4/144","40/17697",0.000306025678836869,0.00301129267975479,0.00205520403260971,"MAPK1/MAPK3/YES1/PIK3R1",4]
["GO:0046965","retinoid X receptor binding","3/144","17/17697",0.000329995541739213,0.00318348640266064,0.00217272606428914,"VDR/PPARG/NR0B2",3]
["GO:0004252","serine-type endopeptidase activity","7/144","160/17697",0.000337705665292493,0.00319521514084436,0.00218073091555274,"MMP9/F2/MMP2/PLAT/PCSK7/DPP4/CTRB1",7]
["GO:0048029","monosaccharide binding","5/144","75/17697",0.000363434810289299,0.00337377220117613,0.0023025959182182,"SELP/GCK/HK2/HK1/GYS1",5]
["GO:0001221","transcription cofactor binding","4/144","43/17697",0.000405513453442105,0.0036946781313614,0.00252161387228132,"ESR1/PPARA/FOXO1/NFE2L2",4]
["GO:0005402","carbohydrate:cation symporter activity","3/144","19/17697",0.000464668684570202,0.0040535294303206,0.00276652949994067,"SLC5A2/SLC5A1/SLC5A4",3]
["GO:0016500","protein-hormone receptor activity","3/144","19/17697",0.000464668684570202,0.0040535294303206,0.00276652949994067,"IGF1R/MCHR1/INSR",3]
["GO:0008201","heparin binding","7/144","169/17697",0.000469616214488362,0.0040535294303206,0.00276652949994067,"FGFR1/SELP/F2/VEGFA/FGF2/PGF/SELL",7]
["GO:0001091","RNA polymerase II basal transcription factor binding","3/144","20/17697",0.000543420655934861,0.00460970625379227,0.0031461195869913,"AR/ESR1/TP53",3]
["GO:0019200","carbohydrate kinase activity","3/144","21/17697",0.000630224888041278,0.00514074182326022,0.00350855079507919,"GCK/HK2/HK1",3]
["GO:0051861","glycolipid binding","3/144","21/17697",0.000630224888041278,0.00514074182326022,0.00350855079507919,"SELP/IL2/SELL",3]
["GO:0050662","coenzyme binding","9/144","291/17697",0.000637368396786329,0.00514074182326022,0.00350855079507919,"NOS2/HMGCR/NOS3/ALDH2/SIRT1/GAPDH/SORD/ACACB/GSR",9]
["GO:0005158","insulin receptor binding","3/144","22/17697",0.000725401090116371,0.00575640865060088,0.00392874274613111,"IGF1R/PIK3R1/PTPN1",3]
["GO:0004175","endopeptidase activity","11/144","427/17697",0.000750003337618474,0.00585716892235379,0.00399751152381442,"BACE2/MMP9/REN/F2/MMP2/CASP3/PLAT/PCSK7/ACE/DPP4/CTRB1",11]
["GO:0045309","protein phosphorylated amino acid binding","4/144","51/17697",0.000780857454252596,0.00600284167956683,0.00409693302477925,"MAPK1/MAPK3/YES1/PIK3R1",4]
["GO:0001223","transcription coactivator binding","3/144","23/17697",0.000829259731129275,0.00618175435932732,0.00421904073732438,"ESR1/PPARA/FOXO1",3]
["GO:0046625","sphingolipid binding","3/144","23/17697",0.000829259731129275,0.00618175435932732,0.00421904073732438,"SELP/IL2/SELL",3]
["GO:0001228","DNA-binding transcription activator activity, RNA polymerase II-specific","11/144","439/17697",0.000939989836372874,0.00690261193276797,0.00471102526006201,"AR/STAT3/ESR1/PPARA/FOS/HNF4A/SIRT1/HIF1A/GLI2/TP53/NFE2L2",11]
["GO:1901681","sulfur compound binding","8/144","250/17697",0.00102447761468901,0.00741239685922051,0.0050589529270247,"FGFR1/SELP/F2/VEGFA/FGF2/PGF/ACACB/SELL",8]
["GO:0004190","aspartic-type endopeptidase activity","3/144","25/17697",0.00106422093179378,0.00758835794844259,0.00517904618218482,"BACE2/REN/CASP3",3]
["GO:0051287","NAD binding","4/144","56/17697",0.00111219287963272,0.00781712709684711,0.00533518088124567,"ALDH2/SIRT1/GAPDH/SORD",4]
["GO:0042974","retinoic acid receptor binding","3/144","26/17697",0.0011958996116733,0.0080600357389488,0.00550096576962916,"VDR/PPARG/NR0B2",3]
["GO:0051019","mitogen-activated protein kinase binding","3/144","26/17697",0.0011958996116733,0.0080600357389488,0.00550096576962916,"MAPK14/SIRT1/ACE",3]
["GO:0070001","aspartic-type peptidase activity","3/144","26/17697",0.0011958996116733,0.0080600357389488,0.00550096576962916,"BACE2/REN/CASP3",3]
["GO:0004497","monooxygenase activity","5/144","99/17697",0.00128894071435818,0.00856971393870573,0.00584882059573626,"NOS2/CYP19A1/NOS3/CYP3A4/CYP26B1",5]
["GO:0008227","G protein-coupled amine receptor activity","4/144","59/17697",0.00135247712029046,0.00875550977872247,0.00597562605779304,"ADRB3/HRH1/TAAR1/ADRB2",4]
["GO:0097110","scaffold protein binding","4/144","59/17697",0.00135247712029046,0.00875550977872247,0.00597562605779304,"MAPK3/KCNQ1/NOS3/IKBKB",4]
["GO:0005520","insulin-like growth factor binding","3/144","28/17697",0.00148902845756934,0.00951431170291061,0.00649350755932496,"IGF1R/INSR/IGFBP3",3]
["GO:0004714","transmembrane receptor protein tyrosine kinase activity","4/144","62/17697",0.00162684104434562,0.010261612741257,0.00700353971857292,"FLT1/FGFR1/IGF1R/INSR",4]
["GO:0043548","phosphatidylinositol 3-kinase binding","3/144","30/17697",0.00182358804990517,0.0113570293740929,0.0077511603986642,"IGF1R/INSR/PIK3R1",3]
["GO:0048018","receptor ligand activity","11/144","482/17697",0.00197664246613163,0.0121563511667095,0.00829669666705249,"F2/NAMPT/IL2/SHH/TNF/TTR/VEGFA/FGF2/IL6/PGF/IL1B",11]
["GO:0005125","cytokine activity","7/144","220/17697",0.00217657654770127,0.0130939707487767,0.00893662102879708,"NAMPT/IL2/TNF/VEGFA/FGF2/IL6/IL1B",7]
["GO:0008083","growth factor activity","6/144","163/17697",0.00218232845812944,0.0130939707487767,0.00893662102879708,"F2/IL2/VEGFA/FGF2/IL6/PGF",6]
["GO:0099106","ion channel regulator activity","5/144","118/17697",0.002788700571729,0.0161390224648986,0.0110148655676137,"PRKCB/CFTR/SGK1/PRKCZ/ADRB2",5]
["GO:0016303","1-phosphatidylinositol-3-kinase activity","2/144","10/17697",0.00283491611008276,0.0161390224648986,0.0110148655676137,"PIK3CA/PIK3CG",2]
["GO:0001103","RNA polymerase II repressing transcription factor binding","3/144","35/17697",0.00285385153342719,0.0161390224648986,0.0110148655676137,"STAT3/PPARG/PPARA",3]
["GO:0001530","lipopolysaccharide binding","3/144","35/17697",0.00285385153342719,0.0161390224648986,0.0110148655676137,"TLR4/SELP/F2",3]
["GO:0016620","oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor","3/144","35/17697",0.00285385153342719,0.0161390224648986,0.0110148655676137,"ALDH2/AKR1B1/GAPDH",3]
["GO:0016616","oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor","5/144","119/17697",0.00289229116376099,0.0161705369610274,0.011036374177509,"HMGCR/HSD11B1/AKR1B1/IMPDH2/SORD",5]
["GO:0035004","phosphatidylinositol 3-kinase activity","2/144","11/17697",0.00344645445234772,0.0190523100062369,0.0130031811980949,"PIK3CA/PIK3CG",2]
["GO:0042056","chemoattractant activity","3/144","38/17697",0.00361362138005503,0.0197544635443008,0.0134824002366965,"VEGFA/FGF2/PGF",3]
["GO:0001540","amyloid-beta binding","4/144","78/17697",0.00376381110752948,0.0203493963176319,0.0138884412180671,"TLR4/BACE2/INSR/ADRB2",4]
["GO:0016709","oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen","3/144","39/17697",0.00389165951571962,0.0206932811771491,0.0141231422668176,"NOS2/NOS3/CYP26B1",3]
["GO:0019199","transmembrane receptor protein kinase activity","4/144","79/17697",0.00393988628729458,0.0206932811771491,0.0141231422668176,"FLT1/FGFR1/IGF1R/INSR",4]
["GO:0016614","oxidoreductase activity, acting on CH-OH group of donors","5/144","128/17697",0.00395359437124394,0.0206932811771491,0.0141231422668176,"HMGCR/HSD11B1/AKR1B1/IMPDH2/SORD",5]
["GO:0008239","dipeptidyl-peptidase activity","2/144","12/17697",0.00411374561735768,0.0213048720393682,0.0145405523760343,"ACE/DPP4",2]
["GO:0008013","beta-catenin binding","4/144","82/17697",0.00450140317710904,0.0230696912826838,0.0157450396216862,"AR/GSK3B/ESR1/FOXO1",4]
["GO:0005172","vascular endothelial growth factor receptor binding","2/144","13/17697",0.00483585457920637,0.0237924045296953,0.0162382906396509,"VEGFA/PGF",2]
["GO:0016653","oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor","2/144","13/17697",0.00483585457920637,0.0237924045296953,0.0162382906396509,"NOS2/NOS3",2]
["GO:0031404","chloride ion binding","2/144","13/17697",0.00483585457920637,0.0237924045296953,0.0162382906396509,"ACE/AMY2A",2]
["GO:0034236","protein kinase A catalytic subunit binding","2/144","13/17697",0.00483585457920637,0.0237924045296953,0.0162382906396509,"GSK3B/KCNQ1",2]
["GO:0033613","activating transcription factor binding","4/144","85/17697",0.00511449414368661,0.024756067022312,0.0168959892599862,"PPARG/FOS/HNF4A/NFE2L2",4]
["GO:0016903","oxidoreductase activity, acting on the aldehyde or oxo group of donors","3/144","43/17697",0.0051323553582842,0.024756067022312,0.0168959892599862,"ALDH2/AKR1B1/GAPDH",3]
["GO:0019838","growth factor binding","5/144","137/17697",0.005268318489369,0.0251651718132966,0.0171752028421943,"FLT1/FGFR1/IGF1R/INSR/IGFBP3",5]
["GO:0015926","glucosidase activity","2/144","14/17697",0.00561185765314207,0.0265484035129413,0.0181192569974931,"MGAM/SI",2]
["GO:0017136","NAD-dependent histone deacetylase activity","2/144","15/17697",0.00644084237501178,0.0298196555618574,0.0203518830214645,"HDAC11/SIRT1",2]
["GO:0070492","oligosaccharide binding","2/144","15/17697",0.00644084237501178,0.0298196555618574,0.0203518830214645,"SELP/SELL",2]
["GO:0016247","channel regulator activity","5/144","144/17697",0.00648516899414378,0.0298196555618574,0.0203518830214645,"PRKCB/CFTR/SGK1/PRKCZ/ADRB2",5]
["GO:0035258","steroid hormone receptor binding","4/144","92/17697",0.00675699383700966,0.030781860813044,0.0210085870760827,"PRKCB/STAT3/ESR1/PPARG",4]
["GO:0004177","aminopeptidase activity","3/144","48/17697",0.00698388602115405,0.030789559246943,0.0210138412489833,"LNPEP/ACE/DPP4",3]
["GO:0004553","hydrolase activity, hydrolyzing O-glycosyl compounds","4/144","94/17697",0.00728336802153495,0.030789559246943,0.0210138412489833,"MGAM/AMY2A/TREH/SI",4]
["GO:0008081","phosphoric diester hydrolase activity","4/144","94/17697",0.00728336802153495,0.030789559246943,0.0210138412489833,"PDE7A/HMOX1/CASR/CCR5",4]
["GO:0004697","protein kinase C activity","2/144","16/17697",0.00732190738189497,0.030789559246943,0.0210138412489833,"PRKCB/PRKCZ",2]
["GO:0005149","interleukin-1 receptor binding","2/144","16/17697",0.00732190738189497,0.030789559246943,0.0210138412489833,"TLR9/IL1B",2]
["GO:0010181","FMN binding","2/144","16/17697",0.00732190738189497,0.030789559246943,0.0210138412489833,"NOS2/NOS3",2]
["GO:0016307","phosphatidylinositol phosphate kinase activity","2/144","16/17697",0.00732190738189497,0.030789559246943,0.0210138412489833,"PIK3CA/PIK3CG",2]
["GO:0034979","NAD-dependent protein deacetylase activity","2/144","16/17697",0.00732190738189497,0.030789559246943,0.0210138412489833,"HDAC11/SIRT1",2]
["GO:0052742","phosphatidylinositol kinase activity","2/144","16/17697",0.00732190738189497,0.030789559246943,0.0210138412489833,"PIK3CA/PIK3CG",2]
["GO:0005506","iron ion binding","5/144","152/17697",0.00810313070927688,0.0335623789141037,0.0229062877056035,"CYP19A1/ALOX12/CYP3A4/CYP26B1/FTO",5]
["GO:0004935","adrenergic receptor activity","2/144","17/17697",0.00825416229391574,0.0335623789141037,0.0229062877056035,"ADRB3/ADRB2",2]
["GO:0017081","chloride channel regulator activity","2/144","17/17697",0.00825416229391574,0.0335623789141037,0.0229062877056035,"CFTR/SGK1",2]
["GO:0035173","histone kinase activity","2/144","17/17697",0.00825416229391574,0.0335623789141037,0.0229062877056035,"PRKCB/PRKAA2",2]
["GO:0015459","potassium channel regulator activity","3/144","52/17697",0.00871585146431345,0.0351491714790345,0.0239892719337014,"SGK1/PRKCZ/ADRB2",3]
["GO:0001102","RNA polymerase II activating transcription factor binding","3/144","53/17697",0.00918458884303565,0.0364420783126898,0.0248716794645872,"FOS/HNF4A/NFE2L2",3]
["GO:0005080","protein kinase C binding","3/144","53/17697",0.00918458884303565,0.0364420783126898,0.0248716794645872,"PRKCB/AKT1/AVPR1A",3]
["GO:0042578","phosphoric ester hydrolase activity","8/144","367/17697",0.0104091159315167,0.0409702803064499,0.0279621724812955,"PDE7A/PTPN1/PON1/ACP1/HMOX1/PTPN22/CASR/CCR5",8]
["GO:0043621","protein self-association","3/144","56/17697",0.0106780750052222,0.0416953404965819,0.0284570252854292,"PPARG/SLC2A1/TP53",3]
["GO:0008329","signaling pattern recognition receptor activity","2/144","20/17697",0.0113493249583655,0.0436239678087175,0.0297733113628175,"TLR4/TLR9",2]
["GO:1901338","catecholamine binding","2/144","20/17697",0.0113493249583655,0.0436239678087175,0.0297733113628175,"ADRB3/ADRB2",2]
["GO:0016597","amino acid binding","3/144","59/17697",0.0123041221964302,0.0469273497724316,0.0320278660192676,"NOS2/NOS3/CASR",3]
["GO:0038187","pattern recognition receptor activity","2/144","21/17697",0.0124776512815576,0.0472231110040486,0.0322297227434564,"TLR4/TLR9",2]

{"sheet":"Sheet2","index":1,"n_rows":2029,"n_cols":9,"rows_kept":2029,"merged":[[0,0,0,8]],"flags":["formulas_cached_only"]}
["Gene Ontology (GO) results in biological processes"]
["ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID","Count"]
["GO:0005996","monosaccharide metabolic process","27/143","292/18670",{"v":1.08578285749199e-21,"d":"1.09E-21"},{"v":2.61912895302973e-18,"d":"2.62E-18"},{"v":1.21911816775619e-18,"d":"1.22E-18"},"GSK3B/MAPK14/PIK3CA/GCK/MTOR/INSR/CLK2/AKT1/SLC2A1/HK2/HK1/PPARA/AKR1B1/TNF/AKT2/GCGR/SIRT1/GAPDH/IGFBP3/KCNJ11/FOXO1/SORD/OGT/TP53/RBP4/ACACB/TKT",27]
["GO:0006006","glucose metabolic process","24/143","209/18670",{"v":1.37257269395926e-21,"d":"1.37E-21"},{"v":2.61912895302973e-18,"d":"2.62E-18"},{"v":1.21911816775619e-18,"d":"1.22E-18"},"GSK3B/MAPK14/PIK3CA/GCK/MTOR/INSR/CLK2/AKT1/HK2/HK1/PPARA/TNF/AKT2/GCGR/SIRT1/GAPDH/IGFBP3/KCNJ11/FOXO1/SORD/OGT/TP53/RBP4/ACACB",24]
["GO:0042593","glucose homeostasis","25/143","241/18670",{"v":2.33504903011572e-21,"d":"2.34E-21"},{"v":2.61912895302973e-18,"d":"2.62E-18"},{"v":1.21911816775619e-18,"d":"1.22E-18"},"BACE2/PIK3CA/IGF1R/GCK/HMGCR/MTNR1B/INSR/STAT3/AKT1/PIK3R1/CNR1/PPARG/HK2/HK1/CFTR/GCGR/HNF4A/SIRT1/KCNJ11/FOXO1/HIF1A/CASR/RBP4/ICAM1/PRKAA2",25]
["GO:0033500","carbohydrate homeostasis","25/143","242/18670",{"v":2.58807208797404e-21,"d":"2.59E-21"},{"v":2.61912895302973e-18,"d":"2.62E-18"},{"v":1.21911816775619e-18,"d":"1.22E-18"},"BACE2/PIK3CA/IGF1R/GCK/HMGCR/MTNR1B/INSR/STAT3/AKT1/PIK3R1/CNR1/PPARG/HK2/HK1/CFTR/GCGR/HNF4A/SIRT1/KCNJ11/FOXO1/HIF1A/CASR/RBP4/ICAM1/PRKAA2",25]
["GO:0019318","hexose metabolic process","25/143","249/18670",{"v":5.24892310325025e-21,"d":"5.25E-21"},{"v":4.2495281443914e-18,"d":"4.25E-18"},{"v":1.97801523259325e-18,"d":"1.98E-18"},"GSK3B/MAPK14/PIK3CA/GCK/MTOR/INSR/CLK2/AKT1/HK2/HK1/PPARA/AKR1B1/TNF/AKT2/GCGR/SIRT1/GAPDH/IGFBP3/KCNJ11/FOXO1/SORD/OGT/TP53/RBP4/ACACB",25]
["GO:0031667","response to nutrient levels","32/143","499/18670",{"v":9.22647044944608e-21,"d":"9.23E-21"},{"v":5.88663153711417e-18,"d":"5.89E-18"},{"v":2.74003288210796e-18,"d":"2.74E-18"},"PTGS2/MAPK1/MAPK8/HMGCR/MTOR/MAPK3/NAMPT/AKT1/CNR1/VDR/PPARG/SLC2A1/PPARA/PON1/GCGR/SIRT1/HMOX1/KCNJ11/FOXO1/EIF2AK3/SORD/OGT/ADRB2/CASR/CYP26B1/TP53/ICAM1/PRKAA2/MC4R/ACACB/NFE2L2/IL1B",32]
["GO:0044262","cellular carbohydrate metabolic process","26/143","286/18670",{"v":1.01794517687251e-20,"d":"1.02E-20"},{"v":5.88663153711417e-18,"d":"5.89E-18"},{"v":2.74003288210796e-18,"d":"2.74E-18"},"BRAF/GSK3B/GCK/MTOR/INSR/CLK2/STAT3/HRH1/AKT1/SLC2A1/HK2/HK1/PPARA/MGAM/AKR1B1/AKT2/GCGR/SIRT1/IGFBP3/FOXO1/SORD/OGT/TP53/ACACB/TREH/GYS1",26]
["GO:1901653","cellular response to peptide","28/143","385/18670",{"v":1.18789948459309e-19,"d":"1.19E-19"},{"v":6.01077139204102e-17,"d":"6.01E-17"},{"v":2.79781589134424e-17,"d":"2.80E-17"},"GSK3B/TLR4/PIK3CA/IGF1R/PRKCB/GCK/INSR/NAMPT/STAT3/AKT1/PIK3R1/PTPN1/PPARG/AKR1B1/AKT2/GCGR/SIRT1/PRKCZ/FOXO1/AGTR1/PTPN22/OGT/ADRB2/CASR/TP53/ICAM1/NFE2L2/IL1B",28]
["GO:0062012","regulation of small molecule metabolic process","29/143","459/18670",{"v":1.15443425287935e-18,"d":"1.15E-18"},{"v":5.19238872850625e-16,"d":"5.19E-16"},{"v":2.4168857457942e-16,"d":"2.42E-16"},"GSK3B/NOS2/PTGS2/GCK/HMGCR/MTOR/INSR/CLK2/STAT3/HRH1/AKT1/NOS3/CNR1/VDR/PPARG/AVPR1A/PPARA/TNF/AKT2/GCGR/SIRT1/IGFBP3/FOXO1/HIF1A/OGT/TP53/PRKAA2/ACACB/IL1B",29]
["GO:0009914","hormone transport","25/143","322/18670",{"v":2.76592582120672e-18,"d":"2.77E-18"},{"v":1.11964677242448e-15,"d":"1.12E-15"},{"v":5.21158654732635e-16,"d":"5.21E-16"},"NOS2/FGFR1/REN/GCK/HMGCR/MTNR1B/BLK/CYP19A1/CNR1/SLC2A1/TNF/TTR/CFTR/HNF4A/DPP4/KCNJ11/IL6/HIF1A/AGTR1/CASR/NR0B2/RBP4/MC4R/HCAR2/IL1B",25]
["GO:1904951","positive regulation of establishment of protein localization","28/143","456/18670",{"v":1.03491902545734e-17,"d":"1.03E-17"},{"v":3.80850201368301e-15,"d":"3.81E-15"},{"v":1.772732110592e-15,"d":"1.77E-15"},"GSK3B/TLR4/MAPK14/PTGS2/MAPK1/MAPK8/GCK/MAPK3/BLK/PIK3R1/HK1/IL2/SHH/TNF/CFTR/HRAS/AKT2/GAPDH/IL6/PRKCZ/HIF1A/PTPN22/CASR/TP53/NR0B2/RBP4/HCAR2/IL1B",28]
["GO:0051222","positive regulation of protein transport","27/143","418/18670",{"v":1.18588831448109e-17,"d":"1.19E-17"},{"v":4.00039658084955e-15,"d":"4.00E-15"},{"v":1.8620527043168e-15,"d":"1.86E-15"},"GSK3B/TLR4/MAPK14/PTGS2/MAPK1/GCK/MAPK3/BLK/PIK3R1/HK1/IL2/SHH/TNF/CFTR/HRAS/AKT2/GAPDH/IL6/PRKCZ/HIF1A/PTPN22/CASR/TP53/NR0B2/RBP4/HCAR2/IL1B",27]
["GO:0046879","hormone secretion","24/143","312/18670",{"v":1.73074314507703e-17,"d":"1.73E-17"},{"v":5.38926788559371e-15,"d":"5.39E-15"},{"v":2.50852650177157e-15,"d":"2.51E-15"},"NOS2/FGFR1/REN/GCK/HMGCR/MTNR1B/BLK/CYP19A1/CNR1/SLC2A1/TNF/CFTR/HNF4A/DPP4/KCNJ11/IL6/HIF1A/AGTR1/CASR/NR0B2/RBP4/MC4R/HCAR2/IL1B",24]
["GO:0050708","regulation of protein secretion","28/143","472/18670",{"v":2.53894133924455e-17,"d":"2.54E-17"},{"v":7.34116752947282e-15,"d":"7.34E-15"},{"v":3.41707142650207e-15,"d":"3.42E-15"},"TLR4/NOS2/MAPK14/TLR9/GCK/HMGCR/MTNR1B/MAPK3/BLK/CNR1/SLC2A1/HK1/IL2/TNF/CFTR/HNF4A/DPP4/GAPDH/KCNJ11/IL6/PRKCZ/HIF1A/PTPN22/CASR/NR0B2/RBP4/HCAR2/IL1B",28]
["GO:0048871","multicellular organismal homeostasis","28/143","485/18670",{"v":5.1325404472434e-17,"d":"5.13E-17"},{"v":1.38510158202942e-14,"d":"1.39E-14"},{"v":6.44719115829171e-15,"d":"6.45E-15"},"TLR4/PTGS2/PIK3CA/TLR9/IGF1R/ADRB3/STAT3/NOS3/CNR1/LNPEP/ALOX12/AVPR2/AKR1B1/TNF/CFTR/FABP4/VEGFA/IL6/FOXO1/OGT/ADRB2/CYP26B1/RBP4/PRKAA2/MC4R/ACACB/FTO/IL1B",28]
["GO:0046883","regulation of hormone secretion","22/143","266/18670",{"v":9.20381578452796e-17,"d":"9.20E-17"},{"v":2.32856539348557e-14,"d":"2.33E-14"},{"v":1.08387041146744e-14,"d":"1.08E-14"},"NOS2/FGFR1/REN/GCK/HMGCR/MTNR1B/BLK/CYP19A1/CNR1/SLC2A1/TNF/CFTR/HNF4A/DPP4/KCNJ11/HIF1A/AGTR1/CASR/NR0B2/RBP4/HCAR2/IL1B",22]
["GO:0002791","regulation of peptide secretion","28/143","500/18670",{"v":1.12601937614235e-16,"d":"1.13E-16"},{"v":2.68125084389662e-14,"d":"2.68E-14"},{"v":1.24803385962527e-14,"d":"1.25E-14"},"TLR4/NOS2/MAPK14/TLR9/GCK/HMGCR/MTNR1B/MAPK3/BLK/CNR1/SLC2A1/HK1/IL2/TNF/CFTR/HNF4A/DPP4/GAPDH/KCNJ11/IL6/PRKCZ/HIF1A/PTPN22/CASR/NR0B2/RBP4/HCAR2/IL1B",28]
["GO:0062013","positive regulation of small molecule metabolic process","18/143","153/18670",{"v":1.33699477662317e-16,"d":"1.34E-16"},{"v":3.00675269765033e-14,"d":"3.01E-14"},{"v":1.399544239857e-14,"d":"1.40E-14"},"NOS2/PTGS2/GCK/INSR/STAT3/HRH1/AKT1/NOS3/PPARG/AVPR1A/PPARA/TNF/AKT2/SIRT1/FOXO1/HIF1A/PRKAA2/IL1B",18]
["GO:0033002","muscle cell proliferation","21/143","239/18670",{"v":1.41831694738877e-16,"d":"1.42E-16"},{"v":3.02176158054196e-14,"d":"3.02E-14"},{"v":1.40653037995894e-14,"d":"1.41E-14"},"MAPK14/PTGS2/MAPK1/FGFR1/MMP9/HMGCR/MTOR/NAMPT/STAT3/AKT1/PPARG/MMP2/ALOX12/AKR1B1/SHH/TNF/FGF2/IGFBP3/HMOX1/IL6/RBP4",21]
["GO:1904659","glucose transmembrane transport","16/143","108/18670",{"v":1.66353023984146e-16,"d":"1.66E-16"},{"v":3.36698520543911e-14,"d":"3.37E-14"},{"v":1.56722059437695e-14,"d":"1.57E-14"},"BRAF/MAPK14/PRKCB/INSR/YES1/AKT1/PIK3R1/SLC5A2/SLC2A1/HK2/TNF/SLC5A1/AKT2/NFE2L2/IL1B/SLC5A4",16]
["GO:0051090","regulation of DNA-binding transcription factor activity","26/143","432/18670",{"v":2.8212222975598e-16,"d":"2.82E-16"},{"v":5.43824183834383e-14,"d":"5.44E-14"},{"v":2.53132226197094e-14,"d":"2.53E-14"},"AR/TLR4/MAPK14/MAPK1/MAPK8/MAPK10/TLR9/PRKCB/MAPK3/STAT3/AKT1/IKBKB/ESR1/PPARG/SHH/TNF/SGK1/VEGFA/FOS/SIRT1/HMOX1/IL6/PRKCZ/NR0B2/ICAM1/IL1B",26]
["GO:0008645","hexose transmembrane transport","16/143","112/18670",{"v":3.03102363600174e-16,"d":"3.03E-16"},{"v":5.57708349024321e-14,"d":"5.58E-14"},{"v":2.59594847293929e-14,"d":"2.60E-14"},"BRAF/MAPK14/PRKCB/INSR/YES1/AKT1/PIK3R1/SLC5A2/SLC2A1/HK2/TNF/SLC5A1/AKT2/NFE2L2/IL1B/SLC5A4",16]
["GO:0043434","response to peptide hormone","26/143","436/18670",{"v":3.52300749570608e-16,"d":"3.52E-16"},{"v":6.2004931924427e-14,"d":"6.20E-14"},{"v":2.8861251337821e-14,"d":"2.89E-14"},"GSK3B/PTGS2/PIK3CA/IGF1R/PRKCB/GCK/MTOR/INSR/STAT3/AKT1/PIK3R1/PTPN1/PPARG/SLC2A1/PPARA/AKT2/GCGR/SIRT1/PRKCZ/FOXO1/AGTR1/OGT/ICAM1/MC4R/NFE2L2/IL1B",26]
["GO:0015749","monosaccharide transmembrane transport","16/143","114/18670",{"v":4.05486499801103e-16,"d":"4.05E-16"},{"v":6.8392056299786e-14,"d":"6.84E-14"},{"v":3.18342471335076e-14,"d":"3.18E-14"},"BRAF/MAPK14/PRKCB/INSR/YES1/AKT1/PIK3R1/SLC5A2/SLC2A1/HK2/TNF/SLC5A1/AKT2/NFE2L2/IL1B/SLC5A4",16]
["GO:0034219","carbohydrate transmembrane transport","16/143","116/18670",{"v":5.39384333227983e-16,"d":"5.39E-16"},{"v":8.7337111236275e-14,"d":"8.73E-14"},{"v":4.06525455359195e-14,"d":"4.07E-14"},"BRAF/MAPK14/PRKCB/INSR/YES1/AKT1/PIK3R1/SLC5A2/SLC2A1/HK2/TNF/SLC5A1/AKT2/NFE2L2/IL1B/SLC5A4",16]
["GO:0010675","regulation of cellular carbohydrate metabolic process","17/143","142/18670",{"v":7.26430091429868e-16,"d":"7.26E-16"},{"v":1.1309957731185e-13,"d":"1.13E-13"},{"v":5.26441240347961e-14,"d":"5.26E-14"},"GSK3B/GCK/MTOR/INSR/CLK2/STAT3/HRH1/AKT1/PPARA/AKT2/GCGR/SIRT1/IGFBP3/FOXO1/OGT/TP53/ACACB",17]
["GO:0003018","vascular process in circulatory system","18/143","173/18670",{"v":1.21637019524247e-15,"d":"1.22E-15"},{"v":1.82365427790427e-13,"d":"1.82E-13"},{"v":8.48850935471355e-14,"d":"8.49E-14"},"PTGS2/ADRB3/HMGCR/MTNR1B/HRH1/YES1/AKT1/NOS3/ALOX12/AVPR2/AVPR1A/VEGFA/ACE/HMOX1/AGTR1/ADRB2/CASR/ICAM1",18]
["GO:0071496","cellular response to external stimulus","23/143","339/18670",{"v":1.33748312279958e-15,"d":"1.34E-15"},{"v":1.93361845753311e-13,"d":"1.93E-13"},{"v":9.00035635267389e-14,"d":"9.00E-14"},"TLR4/PTGS2/MAPK1/MAPK8/MTOR/MAPK3/NAMPT/AKT1/VDR/PPARG/SLC2A1/AVPR1A/FOS/SIRT1/HMOX1/FOXO1/EIF2AK3/CASR/TP53/ICAM1/PRKAA2/NFE2L2/IL1B",23]
["GO:0023061","signal release","26/143","462/18670",{"v":1.41319446056651e-15,"d":"1.41E-15"},{"v":1.97262454357698e-13,"d":"1.97E-13"},{"v":9.18191682182963e-14,"d":"9.18E-14"},"GSK3B/NOS2/FGFR1/REN/PRKCB/GCK/HMGCR/MTNR1B/BLK/CYP19A1/CNR1/SLC2A1/TNF/CFTR/HNF4A/DPP4/KCNJ11/IL6/HIF1A/AGTR1/CASR/NR0B2/RBP4/MC4R/HCAR2/IL1B",26]
["GO:0006109","regulation of carbohydrate metabolic process","19/143","206/18670",{"v":1.78101271424448e-15,"d":"1.78E-15"},{"v":2.40317982242056e-13,"d":"2.40E-13"},{"v":1.1186009678939e-13,"d":"1.12E-13"},"GSK3B/GCK/MTOR/INSR/CLK2/STAT3/HRH1/AKT1/PPARA/AKT2/GCGR/SIRT1/IGFBP3/FOXO1/HIF1A/OGT/TP53/PRKAA2/ACACB",19]
["GO:0032868","response to insulin","21/143","272/18670",{"v":1.94868107189487e-15,"d":"1.95E-15"},{"v":2.54460031581626e-13,"d":"2.54E-13"},{"v":1.1844275445473e-13,"d":"1.18E-13"},"GSK3B/PIK3CA/IGF1R/PRKCB/GCK/MTOR/INSR/AKT1/PIK3R1/PTPN1/PPARG/SLC2A1/PPARA/AKT2/SIRT1/PRKCZ/FOXO1/OGT/ICAM1/MC4R/IL1B",21]
["GO:0008217","regulation of blood pressure","18/143","182/18670",{"v":2.99806064096576e-15,"d":"3.00E-15"},{"v":3.79254671082169e-13,"d":"3.79E-13"},{"v":1.76530544320024e-13,"d":"1.77E-13"},"AR/NOS2/PTGS2/REN/ADRB3/NAMPT/NOS3/CNR1/PPARG/AVPR2/AVPR1A/PPARA/SGK1/GCGR/ACE/HMOX1/AGTR1/ADRB2",18]
["GO:0016051","carbohydrate biosynthetic process","19/143","214/18670",{"v":3.60760204832663e-15,"d":"3.61E-15"},{"v":4.42532517928067e-13,"d":"4.43E-13"},{"v":2.05984295582286e-13,"d":"2.06E-13"},"GSK3B/GCK/MTOR/INSR/CLK2/HRH1/AKT1/SLC2A1/PPARA/AKR1B1/AKT2/SIRT1/GAPDH/FOXO1/SORD/OGT/RBP4/GYS1/TKT",19]
["GO:0044706","multi-multicellular organism process","19/143","222/18670",{"v":7.09841443792734e-15,"d":"7.10E-15"},{"v":8.4512887190382e-13,"d":"8.45E-13"},{"v":3.93379623649843e-13,"d":"3.93E-13"},"AR/PTGS2/MAPK1/MMP9/MTOR/MAPK3/NAMPT/AKT1/CNR1/ESR1/VDR/MMP2/LNPEP/SLC2A1/AVPR1A/AKR1B1/FOS/PGF/IL1B",19]
["GO:0007565","female pregnancy","18/143","192/18670",{"v":7.71717261046901e-15,"d":"7.72E-15"},{"v":8.92546135062244e-13,"d":"8.93E-13"},{"v":4.15450796172617e-13,"d":"4.15E-13"},"AR/PTGS2/MAPK1/MMP9/MTOR/MAPK3/NAMPT/AKT1/CNR1/ESR1/VDR/MMP2/LNPEP/SLC2A1/AKR1B1/FOS/PGF/IL1B",18]
["GO:0010906","regulation of glucose metabolic process","15/143","117/18670",{"v":1.40671396564593e-14,"d":"1.41E-14"},{"v":1.58177170359297e-12,"d":"1.58E-12"},{"v":7.36262572662634e-13,"d":"7.36E-13"},"GSK3B/GCK/MTOR/INSR/CLK2/AKT1/PPARA/AKT2/GCGR/SIRT1/IGFBP3/FOXO1/OGT/TP53/ACACB",15]
["GO:0035296","regulation of tube diameter","16/143","143/18670",{"v":1.59476266633035e-14,"d":"1.59E-14"},{"v":1.65528186495006e-12,"d":"1.66E-12"},{"v":7.70479128942327e-13,"d":"7.70E-13"},"PTGS2/ADRB3/HMGCR/MTNR1B/HRH1/AKT1/NOS3/ALOX12/AVPR2/AVPR1A/ACE/HMOX1/AGTR1/ADRB2/CASR/ICAM1",16]
["GO:0050880","regulation of blood vessel size","16/143","143/18670",{"v":1.59476266633035e-14,"d":"1.59E-14"},{"v":1.65528186495006e-12,"d":"1.66E-12"},{"v":7.70479128942327e-13,"d":"7.70E-13"},"PTGS2/ADRB3/HMGCR/MTNR1B/HRH1/AKT1/NOS3/ALOX12/AVPR2/AVPR1A/ACE/HMOX1/AGTR1/ADRB2/CASR/ICAM1",16]
["GO:0097746","regulation of blood vessel diameter","16/143","143/18670",{"v":1.59476266633035e-14,"d":"1.59E-14"},{"v":1.65528186495006e-12,"d":"1.66E-12"},{"v":7.70479128942327e-13,"d":"7.70E-13"},"PTGS2/ADRB3/HMGCR/MTNR1B/HRH1/AKT1/NOS3/ALOX12/AVPR2/AVPR1A/ACE/HMOX1/AGTR1/ADRB2/CASR/ICAM1",16]
["GO:0035150","regulation of tube size","16/143","144/18670",{"v":1.78257219218843e-14,"d":"1.78E-14"},{"v":1.80092181813679e-12,"d":"1.80E-12"},{"v":8.38269725001264e-13,"d":"8.38E-13"},"PTGS2/ADRB3/HMGCR/MTNR1B/HRH1/AKT1/NOS3/ALOX12/AVPR2/AVPR1A/ACE/HMOX1/AGTR1/ADRB2/CASR/ICAM1",16]
["GO:0031668","cellular response to extracellular stimulus","20/143","268/18670",{"v":1.82928692491613e-14,"d":"1.83E-14"},{"v":1.80092181813679e-12,"d":"1.80E-12"},{"v":8.38269725001264e-13,"d":"8.38E-13"},"PTGS2/MAPK1/MAPK8/MTOR/MAPK3/NAMPT/VDR/PPARG/SLC2A1/AVPR1A/FOS/SIRT1/HMOX1/FOXO1/EIF2AK3/CASR/TP53/ICAM1/PRKAA2/NFE2L2",20]
["GO:0002237","response to molecule of bacterial origin","22/143","343/18670",{"v":1.86854536466762e-14,"d":"1.87E-14"},{"v":1.80092181813679e-12,"d":"1.80E-12"},{"v":8.38269725001264e-13,"d":"8.38E-13"},"TLR4/NOS2/MAPK14/PTGS2/MAPK1/MAPK8/TLR9/REN/SELP/MAPK3/AKT1/NOS3/CNR1/CASP3/TNF/FOS/SERPINE1/IL6/PTPN22/ICAM1/CCR5/IL1B",22]
["GO:0010827","regulation of glucose transmembrane transport","13/143","78/18670",{"v":2.58382934351955e-14,"d":"2.58E-14"},{"v":2.4324049261784e-12,"d":"2.43E-12"},{"v":1.1322042900612e-12,"d":"1.13E-12"},"BRAF/MAPK14/PRKCB/INSR/YES1/AKT1/PIK3R1/SLC2A1/HK2/TNF/AKT2/NFE2L2/IL1B",13]
["GO:0050796","regulation of insulin secretion","17/143","176/18670",{"v":2.73881571492623e-14,"d":"2.74E-14"},{"v":2.48193375285725e-12,"d":"2.48E-12"},{"v":1.15525832577868e-12,"d":"1.16E-12"},"NOS2/GCK/HMGCR/MTNR1B/BLK/CNR1/SLC2A1/TNF/CFTR/HNF4A/DPP4/KCNJ11/HIF1A/CASR/NR0B2/RBP4/IL1B",17]
["GO:0008643","carbohydrate transport","16/143","148/18670",{"v":2.75906667190159e-14,"d":"2.76E-14"},{"v":2.48193375285725e-12,"d":"2.48E-12"},{"v":1.15525832577868e-12,"d":"1.16E-12"},"BRAF/MAPK14/PRKCB/INSR/YES1/AKT1/PIK3R1/SLC5A2/SLC2A1/HK2/TNF/SLC5A1/AKT2/NFE2L2/IL1B/SLC5A4",16]
["GO:0030073","insulin secretion","18/143","207/18670",{"v":2.88681571191471e-14,"d":"2.89E-14"},{"v":2.54039782648494e-12,"d":"2.54E-12"},{"v":1.1824714243312e-12,"d":"1.18E-12"},"NOS2/GCK/HMGCR/MTNR1B/BLK/CNR1/SLC2A1/TNF/CFTR/HNF4A/DPP4/KCNJ11/HIF1A/CASR/NR0B2/RBP4/MC4R/IL1B",18]
["GO:0070482","response to oxygen levels","23/143","394/18670",{"v":3.35353081809406e-14,"d":"3.35E-14"},{"v":2.88831760673293e-12,"d":"2.89E-12"},{"v":1.34441661016537e-12,"d":"1.34E-12"},"NOS2/PTGS2/MTOR/NAMPT/AKT1/PPARG/MMP2/CASP3/SLC2A1/HK2/PPARA/PLAT/VEGFA/SIRT1/DPP4/HMOX1/FOXO1/HIF1A/PGF/CASR/TP53/ICAM1/NFE2L2",23]
["GO:0031098","stress-activated protein kinase signaling cascade","21/143","315/18670",{"v":3.61553710498731e-14,"d":"3.62E-14"},{"v":3.0491029585393e-12,"d":"3.05E-12"},{"v":1.41925688989633e-12,"d":"1.42E-12"},"TLR4/MAPK14/MAPK1/MAPK8/MAPK10/TLR9/IGF1R/HMGCR/MAPK3/AKT1/IKBKB/PTPN1/AKR1B1/TNF/HRAS/VEGFA/MAP3K9/FOXO1/PTPN22/CASR/IL1B",21]
["GO:1903532","positive regulation of secretion by cell","23/143","399/18670",{"v":4.37989938474588e-14,"d":"4.38E-14"},{"v":3.61833320601047e-12,"d":"3.62E-12"},{"v":1.68421480100862e-12,"d":"1.68E-12"},"TLR4/MAPK14/FGFR1/GCK/MAPK3/BLK/CYP19A1/CNR1/HK1/AVPR1A/IL2/TNF/CFTR/GAPDH/IL6/PRKCZ/HIF1A/PTPN22/CASR/NR0B2/RBP4/HCAR2/IL1B",23]
["GO:0010876","lipid localization","23/143","400/18670",{"v":4.61801746684072e-14,"d":"4.62E-14"},{"v":3.73874694115424e-12,"d":"3.74E-12"},{"v":1.74026342434629e-12,"d":"1.74E-12"},"NOS2/REN/AKT1/CYP19A1/PPARG/PPARA/PON1/SHH/TNF/CFTR/FABP4/FABP2/AKT2/SIRT1/ACE/IL6/AGTR1/RBP4/PRKAA2/ACACB/CETP/FTO/IL1B",23]
["GO:0072593","reactive oxygen species metabolic process","20/143","284/18670",{"v":5.49511600921702e-14,"d":"5.50E-14"},{"v":4.33694782696487e-12,"d":"4.34E-12"},{"v":2.01870621236403e-12,"d":"2.02E-12"},"TLR4/NOS2/MAPK14/PTGS2/F2/MTOR/INSR/STAT3/AKT1/NOS3/ALOX12/HK2/TNF/FOXO1/HIF1A/AGTR1/TP53/ICAM1/NFE2L2/IL1B",20]
["GO:0018209","peptidyl-serine modification","21/143","322/18670",{"v":5.57117803859124e-14,"d":"5.57E-14"},{"v":4.33694782696487e-12,"d":"4.34E-12"},{"v":2.01870621236403e-12,"d":"2.02E-12"},"BRAF/GSK3B/MAPK14/PTGS2/MAPK1/MAPK8/PIK3CA/PRKCB/MTOR/MAPK3/AKT1/IKBKB/TNF/SGK1/VEGFA/AKT2/IL6/PRKCZ/EIF2AK3/PARP2/PRKAA2",21]
["GO:0030072","peptide hormone secretion","19/143","250/18670",{"v":6.21228360292224e-14,"d":"6.21E-14"},{"v":4.70307660065878e-12,"d":"4.70E-12"},{"v":2.18912708424673e-12,"d":"2.19E-12"},"NOS2/GCK/HMGCR/MTNR1B/BLK/CNR1/SLC2A1/TNF/CFTR/HNF4A/DPP4/KCNJ11/IL6/HIF1A/CASR/NR0B2/RBP4/MC4R/IL1B",19]
["GO:0051403","stress-activated MAPK cascade","20/143","286/18670",{"v":6.27386700680766e-14,"d":"6.27E-14"},{"v":4.70307660065878e-12,"d":"4.70E-12"},{"v":2.18912708424673e-12,"d":"2.19E-12"},"TLR4/MAPK14/MAPK1/MAPK8/MAPK10/TLR9/IGF1R/HMGCR/MAPK3/AKT1/IKBKB/PTPN1/TNF/HRAS/VEGFA/MAP3K9/FOXO1/PTPN22/CASR/IL1B",20]
["GO:1905952","regulation of lipid localization","16/143","157/18670",{"v":7.03750387746372e-14,"d":"7.04E-14"},{"v":5.1796028538133e-12,"d":"5.18E-12"},{"v":2.41093434271006e-12,"d":"2.41E-12"},"REN/AKT1/CYP19A1/PPARG/PPARA/PON1/SHH/TNF/AKT2/SIRT1/IL6/AGTR1/ACACB/CETP/FTO/IL1B",16]
["GO:0019216","regulation of lipid metabolic process","23/143","410/18670",{"v":7.77652234200099e-14,"d":"7.78E-14"},{"v":5.62131472150357e-12,"d":"5.62E-12"},{"v":2.61653665266575e-12,"d":"2.62E-12"},"PTGS2/FLT1/PIK3CG/F2/HMGCR/MTOR/AKT1/PIK3R1/CNR1/VDR/PPARG/AVPR1A/PPARA/TNF/FGF2/AKT2/HNF4A/SIRT1/AGTR1/PRKAA2/ACACB/HCAR2/IL1B",23]
["GO:0032496","response to lipopolysaccharide","21/143","330/18670",{"v":9.01410913937436e-14,"d":"9.01E-14"},{"v":6.40159891161182e-12,"d":"6.40E-12"},{"v":2.97973321504711e-12,"d":"2.98E-12"},"TLR4/NOS2/MAPK14/PTGS2/MAPK1/MAPK8/REN/SELP/MAPK3/AKT1/NOS3/CNR1/CASP3/TNF/FOS/SERPINE1/IL6/PTPN22/ICAM1/CCR5/IL1B",21]
["GO:0008202","steroid metabolic process","21/143","331/18670",{"v":9.56394668249461e-14,"d":"9.56E-14"},{"v":6.67497520185141e-12,"d":"6.67E-12"},{"v":3.10698086418609e-12,"d":"3.11E-12"},"FGFR1/HMGCR/HSD11B1/CYP19A1/ESR1/VDR/PON1/AKR1B1/SHH/TNF/CFTR/SIRT1/CYP3A4/LIPE/AGTR1/CYP26B1/NR0B2/PRKAA2/ACACB/CETP/IL1B",21]
["GO:0048511","rhythmic process","20/143","295/18670",{"v":1.12461844495807e-13,"d":"1.12E-13"},{"v":7.71602621218687e-12,"d":"7.72E-12"},{"v":3.59155578318455e-12,"d":"3.59E-12"},"GSK3B/NOS2/MAPK8/MAPK10/MTOR/MTNR1B/NAMPT/NOS3/ESR1/PPARG/CASP3/PPARA/IMPDH2/SERPINE1/HNF4A/SIRT1/OGT/TP53/NR0B2/PRKAA2",20]
["GO:0018105","peptidyl-serine phosphorylation","20/143","299/18670",{"v":1.44826661513707e-13,"d":"1.45E-13"},{"v":9.77097209679142e-12,"d":"9.77E-12"},{"v":4.54806533525501e-12,"d":"4.55E-12"},"BRAF/GSK3B/MAPK14/PTGS2/MAPK1/MAPK8/PIK3CA/PRKCB/MTOR/MAPK3/AKT1/IKBKB/TNF/SGK1/VEGFA/AKT2/IL6/PRKCZ/EIF2AK3/PRKAA2",20]
["GO:2000377","regulation of reactive oxygen species metabolic process","17/143","195/18670",{"v":1.50017763359998e-13,"d":"1.50E-13"},{"v":9.9552771488733e-12,"d":"9.96E-12"},{"v":4.63385325995507e-12,"d":"4.63E-12"},"TLR4/MAPK14/PTGS2/F2/MTOR/INSR/STAT3/AKT1/HK2/TNF/FOXO1/HIF1A/AGTR1/TP53/ICAM1/NFE2L2/IL1B",17]
["GO:0051047","positive regulation of secretion","23/143","428/18670",{"v":1.91658512405675e-13,"d":"1.92E-13"},{"v":1.25134461002931e-11,"d":"1.25E-11"},{"v":5.82459655698061e-12,"d":"5.82E-12"},"TLR4/MAPK14/FGFR1/GCK/MAPK3/BLK/CYP19A1/CNR1/HK1/AVPR1A/IL2/TNF/CFTR/GAPDH/IL6/PRKCZ/HIF1A/PTPN22/CASR/NR0B2/RBP4/HCAR2/IL1B",23]
["GO:0042445","hormone metabolic process","18/143","232/18670",{"v":2.08300422376168e-13,"d":"2.08E-13"},{"v":1.33841287266465e-11,"d":"1.34E-11"},{"v":6.22987061074921e-12,"d":"6.23E-12"},"BACE2/FGFR1/REN/HSD11B1/CYP19A1/ESR1/VDR/AKR1B1/SHH/TNF/TTR/PCSK7/ACE/CYP3A4/HIF1A/CYP26B1/RBP4/IL1B",18]
["GO:0050714","positive regulation of protein secretion","19/143","268/18670",{"v":2.17757678431351e-13,"d":"2.18E-13"},{"v":1.37731731607829e-11,"d":"1.38E-11"},{"v":6.41095796697562e-12,"d":"6.41E-12"},"TLR4/MAPK14/GCK/MAPK3/BLK/HK1/IL2/TNF/CFTR/GAPDH/IL6/PRKCZ/HIF1A/PTPN22/CASR/NR0B2/RBP4/HCAR2/IL1B",19]
["GO:0009895","negative regulation of catabolic process","20/143","308/18670",{"v":2.52341232208679e-13,"d":"2.52E-13"},{"v":1.57150355073959e-11,"d":"1.57E-11"},{"v":7.31483086078601e-12,"d":"7.31E-12"},"NOS2/MAPK14/PIK3CA/PIK3CG/HMGCR/MTOR/NAMPT/STAT3/AKT1/CNR1/PPARA/SHH/TNF/HMOX1/PTPN22/OGT/TP53/ACACB/HCAR2/IL1B",20]
["GO:0071216","cellular response to biotic stimulus","18/143","236/18670",{"v":2.79442493016934e-13,"d":"2.79E-13"},{"v":1.71391395717053e-11,"d":"1.71E-11"},{"v":7.97770434609749e-12,"d":"7.98E-12"},"GSK3B/TLR4/NOS2/MAPK14/MAPK1/MAPK8/MAPK3/AKT1/NOS3/TNF/SERPINE1/IL6/EIF2AK3/PTPN22/TP53/ICAM1/CCR5/IL1B",18]
["GO:0031669","cellular response to nutrient levels","18/143","237/18670",{"v":3.00477002961451e-13,"d":"3.00E-13"},{"v":1.81541926565366e-11,"d":"1.82E-11"},{"v":8.45017808799682e-12,"d":"8.45E-12"},"PTGS2/MAPK1/MAPK8/MTOR/MAPK3/NAMPT/VDR/PPARG/SLC2A1/SIRT1/HMOX1/FOXO1/EIF2AK3/CASR/TP53/ICAM1/PRKAA2/NFE2L2",18]
["GO:0007623","circadian rhythm","17/143","208/18670",{"v":4.32845319088458e-13,"d":"4.33E-13"},{"v":2.53935920531895e-11,"d":"2.54E-11"},{"v":1.18198798042462e-11,"d":"1.18E-11"},"GSK3B/NOS2/MAPK8/MAPK10/MTOR/MTNR1B/NAMPT/PPARG/PPARA/IMPDH2/SERPINE1/HNF4A/SIRT1/OGT/TP53/NR0B2/PRKAA2",17]
["GO:0090276","regulation of peptide hormone secretion","17/143","208/18670",{"v":4.32845319088458e-13,"d":"4.33E-13"},{"v":2.53935920531895e-11,"d":"2.54E-11"},{"v":1.18198798042462e-11,"d":"1.18E-11"},"NOS2/GCK/HMGCR/MTNR1B/BLK/CNR1/SLC2A1/TNF/CFTR/HNF4A/DPP4/KCNJ11/HIF1A/CASR/NR0B2/RBP4/IL1B",17]
["GO:0071375","cellular response to peptide hormone stimulus","20/143","321/18670",{"v":5.45062832915797e-13,"d":"5.45E-13"},{"v":3.15202049663306e-11,"d":"3.15E-11"},{"v":1.46716161040493e-11,"d":"1.47E-11"},"GSK3B/PIK3CA/IGF1R/PRKCB/GCK/INSR/STAT3/AKT1/PIK3R1/PTPN1/PPARG/AKT2/GCGR/SIRT1/PRKCZ/FOXO1/AGTR1/OGT/NFE2L2/IL1B",20]
["GO:0032103","positive regulation of response to external stimulus","20/143","323/18670",{"v":6.11678813170019e-13,"d":"6.12E-13"},{"v":3.48743075452428e-11,"d":"3.49E-11"},{"v":1.62328402605535e-11,"d":"1.62E-11"},"TLR4/MAPK14/PTGS2/FGFR1/TLR9/PIK3CG/F2/MAPK3/CNR1/IL2/TNF/FABP4/VEGFA/FGF2/SERPINE1/IL6/PGF/AGTR1/CASR/IL1B",20]
["GO:0001678","cellular glucose homeostasis","15/143","152/18670",{"v":7.10560181597862e-13,"d":"7.11E-13"},{"v":3.99492724320575e-11,"d":"3.99E-11"},{"v":1.85950690798271e-11,"d":"1.86E-11"},"PIK3CA/IGF1R/GCK/HMGCR/PIK3R1/HK2/HK1/CFTR/SIRT1/KCNJ11/FOXO1/HIF1A/CASR/ICAM1/PRKAA2",15]
["GO:0002793","positive regulation of peptide secretion","19/143","288/18670",{"v":7.87942830274942e-13,"d":"7.88E-13"},{"v":4.36930489993557e-11,"d":"4.37E-11"},{"v":2.03376736293028e-11,"d":"2.03E-11"},"TLR4/MAPK14/GCK/MAPK3/BLK/HK1/IL2/TNF/CFTR/GAPDH/IL6/PRKCZ/HIF1A/PTPN22/CASR/NR0B2/RBP4/HCAR2/IL1B",19]
["GO:0048661","positive regulation of smooth muscle cell proliferation","13/143","101/18670",{"v":8.2354923033848e-13,"d":"8.24E-13"},{"v":4.48221150004489e-11,"d":"4.48E-11"},{"v":2.08632166244029e-11,"d":"2.09E-11"},"PTGS2/MMP9/HMGCR/MTOR/NAMPT/AKT1/MMP2/ALOX12/AKR1B1/TNF/FGF2/HMOX1/IL6",13]
["GO:0036293","response to decreased oxygen levels","21/143","370/18670",{"v":8.30449265077488e-13,"d":"8.30E-13"},{"v":4.48221150004489e-11,"d":"4.48E-11"},{"v":2.08632166244029e-11,"d":"2.09E-11"},"NOS2/PTGS2/MTOR/NAMPT/AKT1/MMP2/CASP3/SLC2A1/HK2/PPARA/PLAT/VEGFA/SIRT1/DPP4/HMOX1/HIF1A/PGF/CASR/TP53/ICAM1/NFE2L2",21]
["GO:2000379","positive regulation of reactive oxygen species metabolic process","13/143","102/18670",{"v":9.37727889408217e-13,"d":"9.38E-13"},{"v":4.99463486358482e-11,"d":"4.99E-11"},{"v":2.32483784216165e-11,"d":"2.32E-11"},"TLR4/MAPK14/PTGS2/F2/MTOR/INSR/AKT1/TNF/AGTR1/TP53/ICAM1/NFE2L2/IL1B",13]
["GO:0071902","positive regulation of protein serine/threonine kinase activity","20/143","334/18670",{"v":1.13692563714534e-12,"d":"1.14E-12"},{"v":5.97698049242124e-11,"d":"5.98E-11"},{"v":2.78208734175006e-11,"d":"2.78E-11"},"TLR4/MAPK14/MAPK1/FLT1/FGFR1/MAPK10/TLR9/PIK3CG/INSR/MAPK3/AKT1/PTPN1/TNF/HRAS/VEGFA/FGF2/SIRT1/MAP3K9/ADRB2/IL1B",20]
["GO:0043467","regulation of generation of precursor metabolites and energy","15/143","158/18670",{"v":1.25628754355835e-12,"d":"1.26E-12"},{"v":6.51981022605669e-11,"d":"6.52E-11"},{"v":3.0347566841693e-11,"d":"3.03E-11"},"GSK3B/NOS2/PIK3CA/GCK/MTOR/INSR/STAT3/AKT1/PPARA/AKT2/GCGR/HIF1A/OGT/TP53/PRKAA2",15]
["GO:0043405","regulation of MAP kinase activity","20/143","337/18670",{"v":1.34087225689766e-12,"d":"1.34E-12"},{"v":6.87069733660977e-11,"d":"6.87E-11"},{"v":3.19808306441946e-11,"d":"3.20E-11"},"TLR4/MAPK14/MAPK1/FLT1/FGFR1/MAPK10/TLR9/PIK3CG/IGF1R/HMGCR/INSR/MAPK3/PTPN1/TNF/HRAS/VEGFA/FGF2/MAP3K9/PTPN22/IL1B",20]
["GO:0034599","cellular response to oxidative stress","19/143","302/18670",{"v":1.82710650012566e-12,"d":"1.83E-12"},{"v":9.24515889063585e-11,"d":"9.25E-11"},{"v":4.30331662529597e-11,"d":"4.30E-11"},"TLR4/MAPK1/MAPK8/MMP9/MAPK3/AKT1/NOS3/MMP2/TNF/FOS/SIRT1/HMOX1/IL6/FOXO1/HIF1A/TP53/PRKAA2/GSR/NFE2L2",19]
["GO:0001101","response to acid chemical","20/143","343/18670",{"v":1.855752703833e-12,"d":"1.86E-12"},{"v":9.27418141372344e-11,"d":"9.27E-11"},{"v":4.3168256528409e-11,"d":"4.32E-11"},"PTGS2/MAPK10/MTOR/CLK2/YES1/AKT1/PPARG/MMP2/CASP3/AVPR1A/PON1/AKR1B1/TNF/VEGFA/FOXO1/RXRG/CYP26B1/RBP4/ICAM1/PRKAA2",20]
["GO:0009743","response to carbohydrate","17/143","230/18670",{"v":2.21680031888076e-12,"d":"2.22E-12"},{"v":1.09434240132065e-10,"d":"1.09E-10"},{"v":5.09380304338455e-11,"d":"5.09E-11"},"PTGS2/PIK3CA/IGF1R/PRKCB/GCK/HMGCR/NAMPT/CASP3/CFTR/HNF4A/KCNJ11/HIF1A/CASR/NR0B2/ICAM1/PRKAA2/IL1B",17]
["GO:0070997","neuron death","20/143","348/18670",{"v":2.42088392169062e-12,"d":"2.42E-12"},{"v":1.18069133915706e-10,"d":"1.18E-10"},{"v":5.49572887739532e-11,"d":"5.50E-11"},"GSK3B/TLR4/PIK3CA/MTOR/MTNR1B/NAMPT/STAT3/AKT1/CASP3/PPARA/TNF/HRAS/AKT2/FOS/SIRT1/GAPDH/HMOX1/HIF1A/PARP2/TP53",20]
["GO:0048660","regulation of smooth muscle cell proliferation","15/143","169/18670",{"v":3.36181148651392e-12,"d":"3.36E-12"},{"v":1.62007296397718e-10,"d":"1.62E-10"},{"v":7.54090546473674e-11,"d":"7.54E-11"},"PTGS2/MMP9/HMGCR/MTOR/NAMPT/AKT1/PPARG/MMP2/ALOX12/AKR1B1/TNF/FGF2/IGFBP3/HMOX1/IL6",15]
["GO:0008286","insulin receptor signaling pathway","14/143","141/18670",{"v":3.95098981275064e-12,"d":"3.95E-12"},{"v":1.87792581721659e-10,"d":"1.88E-10"},{"v":8.74112547539449e-11,"d":"8.74E-11"},"GSK3B/PIK3CA/IGF1R/PRKCB/INSR/AKT1/PIK3R1/PTPN1/AKT2/SIRT1/PRKCZ/FOXO1/OGT/IL1B",14]
["GO:0048659","smooth muscle cell proliferation","15/143","171/18670",{"v":3.98966453262419e-12,"d":"3.99E-12"},{"v":1.87792581721659e-10,"d":"1.88E-10"},{"v":8.74112547539449e-11,"d":"8.74E-11"},"PTGS2/MMP9/HMGCR/MTOR/NAMPT/AKT1/PPARG/MMP2/ALOX12/AKR1B1/TNF/FGF2/IGFBP3/HMOX1/IL6",15]
["GO:0045766","positive regulation of angiogenesis","16/143","204/18670",{"v":4.13580510180874e-12,"d":"4.14E-12"},{"v":1.92433782208296e-10,"d":"1.92E-10"},{"v":8.95715805473399e-11,"d":"8.96E-11"},"PTGS2/FLT1/PRKCB/STAT3/NOS3/HK2/VEGFA/FGF2/SERPINE1/SIRT1/HMOX1/HIF1A/PGF/AGTR1/NFE2L2/IL1B",16]
["GO:0001666","response to hypoxia","20/143","359/18670",{"v":4.27921363542255e-12,"d":"4.28E-12"},{"v":1.96843827229437e-10,"d":"1.97E-10"},{"v":9.16243110933775e-11,"d":"9.16E-11"},"NOS2/PTGS2/MTOR/AKT1/MMP2/CASP3/SLC2A1/HK2/PPARA/PLAT/VEGFA/SIRT1/DPP4/HMOX1/HIF1A/PGF/CASR/TP53/ICAM1/NFE2L2",20]
["GO:0001659","temperature homeostasis","15/143","173/18670",{"v":4.72419955212077e-12,"d":"4.72E-12"},{"v":2.14871458280729e-10,"d":"2.15E-10"},{"v":1.00015578927217e-10,"d":"1.00E-10"},"TLR4/PTGS2/IGF1R/ADRB3/STAT3/CNR1/LNPEP/TNF/FABP4/VEGFA/FOXO1/OGT/ADRB2/FTO/IL1B",15]
["GO:0006066","alcohol metabolic process","20/143","364/18670",{"v":5.50718785819946e-12,"d":"5.51E-12"},{"v":2.47701071666571e-10,"d":"2.48E-10"},{"v":1.15296681475755e-10,"d":"1.15E-10"},"FGFR1/HMGCR/HRH1/VDR/ALDH2/PON1/AKR1B1/TNF/TTR/CFTR/FGF2/CYP3A4/LIPE/SORD/NR0B2/RBP4/PRKAA2/ACACB/CETP/IL1B",20]
["GO:0006869","lipid transport","20/143","365/18670",{"v":5.78940193850108e-12,"d":"5.79E-12"},{"v":2.57532956561015e-10,"d":"2.58E-10"},{"v":1.19873099709855e-10,"d":"1.20E-10"},"NOS2/REN/AKT1/CYP19A1/PPARG/PPARA/PON1/SHH/CFTR/FABP4/FABP2/AKT2/SIRT1/ACE/AGTR1/RBP4/PRKAA2/ACACB/CETP/IL1B",20]
["GO:0010506","regulation of autophagy","19/143","327/18670",{"v":7.38129931237555e-12,"d":"7.38E-12"},{"v":3.24777169744524e-10,"d":"3.25E-10"},{"v":1.51173063720277e-10,"d":"1.51E-10"},"GSK3B/MAPK8/PIK3CA/MTOR/MAPK3/NAMPT/STAT3/AKT1/CASP3/HK2/SIRT1/GAPDH/HMOX1/FOXO1/HIF1A/PTPN22/ADRB2/TP53/PRKAA2",19]
["GO:0014065","phosphatidylinositol 3-kinase signaling","14/143","148/18670",{"v":7.6862492375564e-12,"d":"7.69E-12"},{"v":3.34558461436863e-10,"d":"3.35E-10"},{"v":1.55725932486994e-10,"d":"1.56E-10"},"MAPK1/FLT1/FGFR1/PIK3CA/PIK3CG/IGF1R/SELP/F2/INSR/MAPK3/AKT1/PIK3R1/TNF/SIRT1",14]
["GO:0050994","regulation of lipid catabolic process","10/143","54/18670",{"v":9.07649472514336e-12,"d":"9.08E-12"},{"v":3.87395645095259e-10,"d":"3.87E-10"},{"v":1.80319899292832e-10,"d":"1.80E-10"},"PIK3CG/MTOR/AKT1/CNR1/PPARA/TNF/AKT2/ACACB/HCAR2/IL1B",10]
["GO:0048015","phosphatidylinositol-mediated signaling","15/143","181/18670",{"v":9.09154799507154e-12,"d":"9.09E-12"},{"v":3.87395645095259e-10,"d":"3.87E-10"},{"v":1.80319899292832e-10,"d":"1.80E-10"},"MAPK1/FLT1/FGFR1/PIK3CA/PIK3CG/IGF1R/SELP/F2/INSR/MAPK3/AKT1/PIK3R1/TNF/SIRT1/OGT",15]
["GO:0019217","regulation of fatty acid metabolic process","12/143","96/18670",{"v":9.2075198754932e-12,"d":"9.21E-12"},{"v":3.8825042141663e-10,"d":"3.88E-10"},{"v":1.80717769486105e-10,"d":"1.81E-10"},"PTGS2/MTOR/AKT1/CNR1/PPARG/AVPR1A/PPARA/AKT2/SIRT1/PRKAA2/ACACB/IL1B",12]
["GO:0032869","cellular response to insulin stimulus","16/143","216/18670",{"v":9.88543467970565e-12,"d":"9.89E-12"},{"v":4.12538552406685e-10,"d":"4.13E-10"},{"v":1.92023093615552e-10,"d":"1.92E-10"},"GSK3B/PIK3CA/IGF1R/PRKCB/GCK/INSR/AKT1/PIK3R1/PTPN1/PPARG/AKT2/SIRT1/PRKCZ/FOXO1/OGT/IL1B",16]
["GO:0043255","regulation of carbohydrate biosynthetic process","12/143","97/18670",{"v":1.04392528560098e-11,"d":"1.04E-11"},{"v":4.312050567462e-10,"d":"4.31E-10"},{"v":2.00711735899651e-10,"d":"2.01E-10"},"GSK3B/GCK/MTOR/INSR/CLK2/HRH1/AKT1/PPARA/AKT2/SIRT1/FOXO1/OGT",12]
["GO:0048017","inositol lipid-mediated signaling","15/143","184/18670",{"v":1.15245726997127e-11,"d":"1.15E-11"},{"v":4.71226972610474e-10,"d":"4.71E-10"},{"v":2.19340618101921e-10,"d":"2.19E-10"},"MAPK1/FLT1/FGFR1/PIK3CA/PIK3CG/IGF1R/SELP/F2/INSR/MAPK3/AKT1/PIK3R1/TNF/SIRT1/OGT",15]
["GO:0014066","regulation of phosphatidylinositol 3-kinase signaling","13/143","124/18670",{"v":1.19222062518443e-11,"d":"1.19E-11"},{"v":4.82610909074657e-10,"d":"4.83E-10"},{"v":2.24639465166329e-10,"d":"2.25E-10"},"MAPK1/FLT1/FGFR1/PIK3CA/PIK3CG/IGF1R/SELP/F2/INSR/MAPK3/PIK3R1/TNF/SIRT1",13]
["GO:0043406","positive regulation of MAP kinase activity","17/143","258/18670",{"v":1.39553676729416e-11,"d":"1.40E-11"},{"v":5.59320082574926e-10,"d":"5.59E-10"},{"v":2.60345056118452e-10,"d":"2.60E-10"},"TLR4/MAPK14/MAPK1/FLT1/FGFR1/MAPK10/TLR9/PIK3CG/INSR/MAPK3/PTPN1/TNF/HRAS/VEGFA/FGF2/MAP3K9/IL1B",17]
["GO:0048608","reproductive structure development","21/143","431/18670",{"v":1.50988131982937e-11,"d":"1.51E-11"},{"v":5.99215645359732e-10,"d":"5.99E-10"},{"v":2.78915125128438e-10,"d":"2.79E-10"},"AR/MAPK14/PTGS2/MAPK1/REN/INSR/MAPK3/AKT1/CYP19A1/NOS3/ESR1/VDR/PPARG/CASP3/SHH/VEGFA/SIRT1/HIF1A/GLI2/RBP4/ICAM1",21]
["GO:0050673","epithelial cell proliferation","21/143","434/18670",{"v":1.71960732489165e-11,"d":"1.72E-11"},{"v":6.6932408184244e-10,"d":"6.69E-10"},{"v":3.11548290643324e-10,"d":"3.12E-10"},"AR/MAPK1/FLT1/FGFR1/MTOR/STAT3/AKT1/ESR1/VDR/PPARG/SHH/TNF/HRAS/VEGFA/FGF2/SIRT1/IGFBP3/HMOX1/HIF1A/PGF/AGTR1",21]
["GO:0061458","reproductive system development","21/143","434/18670",{"v":1.71960732489165e-11,"d":"1.72E-11"},{"v":6.6932408184244e-10,"d":"6.69E-10"},{"v":3.11548290643324e-10,"d":"3.12E-10"},"AR/MAPK14/PTGS2/MAPK1/REN/INSR/MAPK3/AKT1/CYP19A1/NOS3/ESR1/VDR/PPARG/CASP3/SHH/VEGFA/SIRT1/HIF1A/GLI2/RBP4/ICAM1",21]
["GO:0043536","positive regulation of blood vessel endothelial cell migration","11/143","79/18670",{"v":2.08920201682525e-11,"d":"2.09E-11"},{"v":8.05437120391297e-10,"d":"8.05E-10"},{"v":3.74904422066887e-10,"d":"3.75E-10"},"PTGS2/FGFR1/AKT1/NOS3/ALOX12/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/NFE2L2",11]
["GO:1904018","positive regulation of vasculature development","16/143","230/18670",{"v":2.55556509132693e-11,"d":"2.56E-11"},{"v":9.75936555631266e-10,"d":"9.76E-10"},{"v":4.54266287336168e-10,"d":"4.54E-10"},"PTGS2/FLT1/PRKCB/STAT3/NOS3/HK2/VEGFA/FGF2/SERPINE1/SIRT1/HMOX1/HIF1A/PGF/AGTR1/NFE2L2/IL1B",16]
["GO:0050900","leukocyte migration","22/143","499/18670",{"v":3.30932497420177e-11,"d":"3.31E-11"},{"v":1.25197640145503e-09,"d":"1.25E-09"},{"v":5.82753733774832e-10,"d":"5.83E-10"},"MAPK14/FLT1/PIK3CA/PIK3CG/SELP/F2/MAPK3/HRH1/YES1/AKT1/CYP19A1/PIK3R1/TNF/VEGFA/SERPINE1/HMOX1/IL6/PGF/ICAM1/CCR5/IL1B/SELL",22]
["GO:0006979","response to oxidative stress","21/143","451/18670",{"v":3.52417715233047e-11,"d":"3.52E-11"},{"v":1.30458215589355e-09,"d":"1.30E-09"},{"v":6.07239977909679e-10,"d":"6.07E-10"},"TLR4/PTGS2/MAPK1/MAPK8/MMP9/MAPK3/AKT1/NOS3/MMP2/CASP3/TNF/FOS/SIRT1/HMOX1/IL6/FOXO1/HIF1A/TP53/PRKAA2/GSR/NFE2L2",21]
["GO:0046777","protein autophosphorylation","16/143","235/18670",{"v":3.53130546412571e-11,"d":"3.53E-11"},{"v":1.30458215589355e-09,"d":"1.30E-09"},{"v":6.07239977909679e-10,"d":"6.07E-10"},"GSK3B/FLT1/FGFR1/STK17B/IGF1R/MTOR/INSR/MAPK3/BLK/CLK2/YES1/AKT1/VEGFA/ACE/MAP3K9/EIF2AK3",16]
["GO:0016052","carbohydrate catabolic process","15/143","199/18670",{"v":3.54506020623248e-11,"d":"3.55E-11"},{"v":1.30458215589355e-09,"d":"1.30E-09"},{"v":6.07239977909679e-10,"d":"6.07E-10"},"GCK/INSR/STAT3/HK2/HK1/PPARA/MGAM/GAPDH/HIF1A/SORD/OGT/TP53/PRKAA2/AMY2A/TREH",15]
["GO:0031331","positive regulation of cellular catabolic process","19/143","361/18670",{"v":4.0923502553581e-11,"d":"4.09E-11"},{"v":1.49241746249456e-09,"d":"1.49E-09"},{"v":6.94671119686202e-10,"d":"6.95E-10"},"GSK3B/INSR/MAPK3/AKT1/PTPN1/HK2/PPARA/TNF/AKT2/SIRT1/HMOX1/IL6/FOXO1/HIF1A/ADRB2/PRKAA2/FTO/NFE2L2/IL1B",19]
["GO:0009746","response to hexose","15/143","202/18670",{"v":4.38763694945511e-11,"d":"4.39E-11"},{"v":1.58581735458878e-09,"d":"1.59E-09"},{"v":7.38145689804949e-10,"d":"7.38E-10"},"PTGS2/PIK3CA/IGF1R/GCK/HMGCR/NAMPT/CASP3/CFTR/HNF4A/KCNJ11/HIF1A/CASR/NR0B2/ICAM1/PRKAA2",15]
["GO:0018108","peptidyl-tyrosine phosphorylation","19/143","363/18670",{"v":4.49954628300728e-11,"d":"4.50E-11"},{"v":1.61187286315164e-09,"d":"1.61E-09"},{"v":7.5027366991924e-10,"d":"7.50E-10"},"FLT1/FGFR1/IGF1R/MTOR/INSR/MAPK3/BLK/CLK2/STAT3/YES1/PTPN1/IL2/TNF/VEGFA/ACE/IL6/PRKCZ/TP53/ICAM1",19]
["GO:0010038","response to metal ion","19/143","364/18670",{"v":4.71701794227263e-11,"d":"4.72E-11"},{"v":1.67495514301049e-09,"d":"1.67E-09"},{"v":7.79636391197416e-10,"d":"7.80E-10"},"BRAF/PTGS2/MAPK1/MAPK8/MMP9/MAPK3/AKT1/CASP3/SHH/FABP4/FOS/HMOX1/HIF1A/EIF2AK3/SORD/CASR/ICAM1/PRKAA2/NFE2L2",19]
["GO:0007568","aging","18/143","321/18670",{"v":4.91838224434163e-11,"d":"4.92E-11"},{"v":1.73127055000825e-09,"d":"1.73E-09"},{"v":8.05849356281145e-10,"d":"8.06E-10"},"MAPK14/PTGS2/MAPK1/HMGCR/MTOR/MAPK3/NAMPT/STAT3/AKT1/CNR1/ALOX12/HRAS/FOS/SERPINE1/SIRT1/TP53/ICAM1/NFE2L2",18]
["GO:0018212","peptidyl-tyrosine modification","19/143","366/18670",{"v":5.18165717384679e-11,"d":"5.18E-11"},{"v":1.80821967583895e-09,"d":"1.81E-09"},{"v":8.41666637131194e-10,"d":"8.42E-10"},"FLT1/FGFR1/IGF1R/MTOR/INSR/MAPK3/BLK/CLK2/STAT3/YES1/PTPN1/IL2/TNF/VEGFA/ACE/IL6/PRKCZ/TP53/ICAM1",19]
["GO:0060135","maternal process involved in female pregnancy","10/143","64/18670",{"v":5.38363365777652e-11,"d":"5.38E-11"},{"v":1.8563137813215e-09,"d":"1.86E-09"},{"v":8.64052857438496e-10,"d":"8.64E-10"},"AR/PTGS2/MAPK1/MTOR/MAPK3/AKT1/CNR1/ESR1/VDR/AKR1B1",10]
["GO:0071222","cellular response to lipopolysaccharide","15/143","205/18670",{"v":5.41119135859528e-11,"d":"5.41E-11"},{"v":1.8563137813215e-09,"d":"1.86E-09"},{"v":8.64052857438496e-10,"d":"8.64E-10"},"TLR4/NOS2/MAPK14/MAPK1/MAPK8/MAPK3/AKT1/NOS3/TNF/SERPINE1/IL6/PTPN22/ICAM1/CCR5/IL1B",15]
["GO:0035690","cellular response to drug","19/143","369/18670",{"v":5.9591554646315e-11,"d":"5.96E-11"},{"v":2.01461305037872e-09,"d":"2.01E-09"},{"v":9.37735947622712e-10,"d":"9.38E-10"},"NOS2/PTGS2/MAPK1/REN/MAPK3/KCNQ1/TNF/CFTR/SIRT1/HMOX1/KCNJ11/IL6/FOXO1/PTPN22/TP53/ICAM1/PRKAA2/NFE2L2/IL1B",19]
["GO:0001819","positive regulation of cytokine production","21/143","464/18670",{"v":5.9721730742452e-11,"d":"5.97E-11"},{"v":2.01461305037872e-09,"d":"2.01E-09"},{"v":9.37735947622712e-10,"d":"9.38E-10"},"TLR4/MAPK14/PTGS2/TLR9/MAPK3/STAT3/PIK3R1/HK1/IL2/TNF/HRAS/SERPINE1/AGPAT2/GAPDH/HMOX1/IL6/PRKCZ/HIF1A/EIF2AK3/PTPN22/IL1B",21]
["GO:0014068","positive regulation of phosphatidylinositol 3-kinase signaling","11/143","87/18670",{"v":6.14594365361052e-11,"d":"6.15E-11"},{"v":2.04409569652392e-09,"d":"2.04E-09"},{"v":9.51459147279438e-10,"d":"9.51E-10"},"FLT1/FGFR1/PIK3CA/PIK3CG/IGF1R/SELP/F2/INSR/PIK3R1/TNF/SIRT1",11]
["GO:0006733","oxidoreduction coenzyme metabolic process","15/143","207/18670",{"v":6.21106152846941e-11,"d":"6.21E-11"},{"v":2.04409569652392e-09,"d":"2.04E-09"},{"v":9.51459147279438e-10,"d":"9.51E-10"},"PTGS2/GCK/HMGCR/INSR/NAMPT/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2/TKT",15]
["GO:0034284","response to monosaccharide","15/143","207/18670",{"v":6.21106152846941e-11,"d":"6.21E-11"},{"v":2.04409569652392e-09,"d":"2.04E-09"},{"v":9.51459147279438e-10,"d":"9.51E-10"},"PTGS2/PIK3CA/IGF1R/GCK/HMGCR/NAMPT/CASP3/CFTR/HNF4A/KCNJ11/HIF1A/CASR/NR0B2/ICAM1/PRKAA2",15]
["GO:0001936","regulation of endothelial cell proliferation","14/143","176/18670",{"v":8.04063720682384e-11,"d":"8.04E-11"},{"v":2.61254522910476e-09,"d":"2.61E-09"},{"v":1.21605366135259e-09,"d":"1.22E-09"},"FLT1/FGFR1/MTOR/STAT3/AKT1/PPARG/TNF/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/PGF/AGTR1",14]
["GO:0071214","cellular response to abiotic stimulus","18/143","331/18670",{"v":8.13193426055337e-11,"d":"8.13E-11"},{"v":2.61254522910476e-09,"d":"2.61E-09"},{"v":1.21605366135259e-09,"d":"1.22E-09"},"TLR4/MAPK14/PTGS2/MAPK8/MAPK10/MAPK3/NAMPT/AKT1/PIK3R1/CASP3/SLC2A1/AVPR1A/AKR1B1/HRAS/AKT2/SIRT1/TP53/IL1B",18]
["GO:0104004","cellular response to environmental stimulus","18/143","331/18670",{"v":8.13193426055337e-11,"d":"8.13E-11"},{"v":2.61254522910476e-09,"d":"2.61E-09"},{"v":1.21605366135259e-09,"d":"1.22E-09"},"TLR4/MAPK14/PTGS2/MAPK8/MAPK10/MAPK3/NAMPT/AKT1/PIK3R1/CASP3/SLC2A1/AVPR1A/AKR1B1/HRAS/AKT2/SIRT1/TP53/IL1B",18]
["GO:0071219","cellular response to molecule of bacterial origin","15/143","212/18670",{"v":8.71005732123926e-11,"d":"8.71E-11"},{"v":2.77624504223437e-09,"d":"2.78E-09"},{"v":1.29225052673173e-09,"d":"1.29E-09"},"TLR4/NOS2/MAPK14/MAPK1/MAPK8/MAPK3/AKT1/NOS3/TNF/SERPINE1/IL6/PTPN22/ICAM1/CCR5/IL1B",15]
["GO:0045834","positive regulation of lipid metabolic process","13/143","146/18670",{"v":9.55535361386715e-11,"d":"9.56E-11"},{"v":3.02188058038549e-09,"d":"3.02E-09"},{"v":1.40658577046235e-09,"d":"1.41E-09"},"PTGS2/FLT1/F2/MTOR/AKT1/PPARG/AVPR1A/PPARA/TNF/FGF2/AKT2/AGTR1/IL1B",13]
["GO:0019359","nicotinamide nucleotide biosynthetic process","13/143","147/18670",{"v":1.04144114845413e-10,"d":"1.04E-10"},{"v":3.24288751457101e-09,"d":"3.24E-09"},{"v":1.50945721111975e-09,"d":"1.51E-09"},"PTGS2/GCK/INSR/NAMPT/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",13]
["GO:0019363","pyridine nucleotide biosynthetic process","13/143","147/18670",{"v":1.04144114845413e-10,"d":"1.04E-10"},{"v":3.24288751457101e-09,"d":"3.24E-09"},{"v":1.50945721111975e-09,"d":"1.51E-09"},"PTGS2/GCK/INSR/NAMPT/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",13]
["GO:0007159","leukocyte cell-cell adhesion","18/143","337/18670",{"v":1.09036303377062e-10,"d":"1.09E-10"},{"v":3.36930500817059e-09,"d":"3.37E-09"},{"v":1.56830038605819e-09,"d":"1.57E-09"},"PIK3CA/SELP/YES1/AKT1/PIK3R1/CASP3/PPARA/IL2/SHH/TNF/DPP4/IL6/PRKCZ/GLI2/PTPN22/ICAM1/IL1B/SELL",18]
["GO:0071241","cellular response to inorganic substance","15/143","217/18670",{"v":1.2105788571449e-10,"d":"1.21E-10"},{"v":3.71244182857768e-09,"d":"3.71E-09"},{"v":1.72801926179375e-09,"d":"1.73E-09"},"BRAF/PTGS2/MAPK1/MAPK8/MMP9/MAPK3/AKT1/SHH/FABP4/FOS/HMOX1/FOXO1/EIF2AK3/PRKAA2/NFE2L2",15]
["GO:0009165","nucleotide biosynthetic process","19/143","386/18670",{"v":1.28430217970784e-10,"d":"1.28E-10"},{"v":3.90187686075383e-09,"d":"3.90E-09"},{"v":1.81619502307816e-09,"d":"1.82E-09"},"NOS2/PTGS2/MAPK1/GCK/INSR/NAMPT/STAT3/NOS3/HK2/HK1/PPARA/IMPDH2/AGPAT2/GAPDH/HIF1A/OGT/TP53/PRKAA2/ACACB",19]
["GO:0010001","glial cell differentiation","15/143","218/18670",{"v":1.29162919797681e-10,"d":"1.29E-10"},{"v":3.90187686075383e-09,"d":"3.90E-09"},{"v":1.81619502307816e-09,"d":"1.82E-09"},"TLR4/BACE2/MAPK1/F2/MTOR/MAPK3/STAT3/AKT1/PPARG/HDAC11/SHH/TNF/AKT2/IL6/IL1B",15]
["GO:0007599","hemostasis","18/143","341/18670",{"v":1.32139204043151e-10,"d":"1.32E-10"},{"v":3.96221850345686e-09,"d":"3.96E-09"},{"v":1.84428206812663e-09,"d":"1.84E-09"},"TLR4/MAPK1/PIK3CA/PIK3CG/PRKCB/SELP/F2/MAPK3/NOS3/PIK3R1/ALOX12/AVPR2/PLAT/SHH/SERPINE1/HNF4A/IL6/NFE2L2",18]
["GO:0072525","pyridine-containing compound biosynthetic process","13/143","150/18670",{"v":1.34309527970082e-10,"d":"1.34E-10"},{"v":3.99768359722715e-09,"d":"4.00E-09"},{"v":1.8607898998951e-09,"d":"1.86E-09"},"PTGS2/GCK/INSR/NAMPT/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",13]
["GO:0072330","monocarboxylic acid biosynthetic process","18/143","343/18670",{"v":1.45323281566698e-10,"d":"1.45E-10"},{"v":4.29393170643792e-09,"d":"4.29E-09"},{"v":1.99868362661844e-09,"d":"2.00E-09"},"PTGS2/GCK/INSR/STAT3/ALOX12/HK2/HK1/AVPR1A/PPARA/SIRT1/GAPDH/CYP3A4/HIF1A/OGT/TP53/PRKAA2/ACACB/IL1B",18]
["GO:1901293","nucleoside phosphate biosynthetic process","19/143","390/18670",{"v":1.52979023592869e-10,"d":"1.53E-10"},{"v":4.48738469205748e-09,"d":"4.49E-09"},{"v":2.08872961274779e-09,"d":"2.09E-09"},"NOS2/PTGS2/MAPK1/GCK/INSR/NAMPT/STAT3/NOS3/HK2/HK1/PPARA/IMPDH2/AGPAT2/GAPDH/HIF1A/OGT/TP53/PRKAA2/ACACB",19]
["GO:0051091","positive regulation of DNA-binding transcription factor activity","16/143","261/18670",{"v":1.68705612360328e-10,"d":"1.69E-10"},{"v":4.91309581895401e-09,"d":"4.91E-09"},{"v":2.28688410545238e-09,"d":"2.29E-09"},"AR/TLR4/TLR9/PRKCB/STAT3/AKT1/IKBKB/ESR1/PPARG/SHH/TNF/VEGFA/IL6/PRKCZ/ICAM1/IL1B",16]
["GO:0048638","regulation of developmental growth","18/143","347/18670",{"v":1.75430683970416e-10,"d":"1.75E-10"},{"v":5.07245291937318e-09,"d":"5.07E-09"},{"v":2.36105958125598e-09,"d":"2.36E-09"},"AR/GSK3B/MAPK14/MAPK1/FGFR1/PIK3CA/MTOR/INSR/STAT3/AKT1/PPARA/VEGFA/FGF2/ADRB2/PARP2/RBP4/ACACB/FTO",18]
["GO:0019362","pyridine nucleotide metabolic process","14/143","189/18670",{"v":2.08045880989501e-10,"d":"2.08E-10"},{"v":5.93077272003873e-09,"d":"5.93E-09"},{"v":2.76057914730324e-09,"d":"2.76E-09"},"PTGS2/GCK/INSR/NAMPT/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2/TKT",14]
["GO:0046496","nicotinamide nucleotide metabolic process","14/143","189/18670",{"v":2.08045880989501e-10,"d":"2.08E-10"},{"v":5.93077272003873e-09,"d":"5.93E-09"},{"v":2.76057914730324e-09,"d":"2.76E-09"},"PTGS2/GCK/INSR/NAMPT/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2/TKT",14]
["GO:0071248","cellular response to metal ion","14/143","190/18670",{"v":2.23140700123921e-10,"d":"2.23E-10"},{"v":6.31659828043099e-09,"d":"6.32E-09"},{"v":2.94016822393683e-09,"d":"2.94E-09"},"BRAF/PTGS2/MAPK1/MAPK8/MMP9/MAPK3/AKT1/SHH/FABP4/FOS/HMOX1/EIF2AK3/PRKAA2/NFE2L2",14]
["GO:0046364","monosaccharide biosynthetic process","11/143","98/18670",{"v":2.28905411621489e-10,"d":"2.29E-10"},{"v":6.43478546002629e-09,"d":"6.43E-09"},{"v":2.99518045908234e-09,"d":"3.00E-09"},"GCK/CLK2/PPARA/AKR1B1/SIRT1/GAPDH/FOXO1/SORD/OGT/RBP4/TKT",11]
["GO:0001935","endothelial cell proliferation","14/143","191/18670",{"v":2.39231069595815e-10,"d":"2.39E-10"},{"v":6.67867151533695e-09,"d":"6.68E-09"},{"v":3.108701376236e-09,"d":"3.11E-09"},"FLT1/FGFR1/MTOR/STAT3/AKT1/PPARG/TNF/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/PGF/AGTR1",14]
["GO:0032368","regulation of lipid transport","12/143","127/18670",{"v":2.59029388556849e-10,"d":"2.59E-10"},{"v":7.18185592382276e-09,"d":"7.18E-09"},{"v":3.3429171270134e-09,"d":"3.34E-09"},"REN/AKT1/CYP19A1/PPARG/PPARA/PON1/SHH/AKT2/SIRT1/AGTR1/CETP/IL1B",12]
["GO:0022407","regulation of cell-cell adhesion","19/143","403/18670",{"v":2.66267756732786e-10,"d":"2.66E-10"},{"v":7.33232570921304e-09,"d":"7.33E-09"},{"v":3.41295585071025e-09,"d":"3.41E-09"},"MAPK14/PIK3CA/YES1/AKT1/PIK3R1/CASP3/ALOX12/PPARA/IL2/SHH/TNF/VEGFA/DPP4/IL6/PRKCZ/GLI2/PTPN22/ICAM1/IL1B",19]
["GO:1901214","regulation of neuron death","17/143","313/18670",{"v":2.87911082831424e-10,"d":"2.88E-10"},{"v":7.87475718447029e-09,"d":"7.87E-09"},{"v":3.66543981698612e-09,"d":"3.67E-09"},"GSK3B/TLR4/PIK3CA/MTOR/MTNR1B/STAT3/AKT1/CASP3/PPARA/TNF/HRAS/FOS/SIRT1/HMOX1/HIF1A/PARP2/TP53",17]
["GO:0050995","negative regulation of lipid catabolic process","7/143","23/18670",{"v":2.95174181934047e-10,"d":"2.95E-10"},{"v":8.01922878167128e-09,"d":"8.02E-09"},{"v":3.7326865818576e-09,"d":"3.73E-09"},"PIK3CG/AKT1/CNR1/TNF/ACACB/HCAR2/IL1B",7]
["GO:2001233","regulation of apoptotic signaling pathway","19/143","406/18670",{"v":3.01690020881578e-10,"d":"3.02E-10"},{"v":8.14160803019086e-09,"d":"8.14E-09"},{"v":3.78965008686334e-09,"d":"3.79E-09"},"AR/GSK3B/PTGS2/FGFR1/MAPK8/MMP9/AKT1/NOS3/PTPN1/TNF/SERPINE1/SIRT1/HMOX1/HIF1A/EIF2AK3/TP53/ICAM1/NFE2L2/IL1B",19]
["GO:0000302","response to reactive oxygen species","15/143","232/18670",{"v":3.09298573388459e-10,"d":"3.09E-10"},{"v":8.29165976871843e-09,"d":"8.29E-09"},{"v":3.85949422352975e-09,"d":"3.86E-09"},"MAPK1/MAPK8/MMP9/MAPK3/AKT1/NOS3/MMP2/CASP3/TNF/FOS/SIRT1/HMOX1/IL6/FOXO1/NFE2L2",15]
["GO:0072524","pyridine-containing compound metabolic process","14/143","195/18670",{"v":3.14776745767333e-10,"d":"3.15E-10"},{"v":8.38300175569844e-09,"d":"8.38E-09"},{"v":3.90201090667261e-09,"d":"3.90E-09"},"PTGS2/GCK/INSR/NAMPT/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2/TKT",14]
["GO:0006809","nitric oxide biosynthetic process","10/143","77/18670",{"v":3.5830888595204e-10,"d":"3.58E-10"},{"v":9.47996320479645e-09,"d":"9.48E-09"},{"v":4.41261029139423e-09,"d":"4.41E-09"},"TLR4/NOS2/PTGS2/MTOR/INSR/AKT1/NOS3/TNF/ICAM1/IL1B",10]
["GO:0032872","regulation of stress-activated MAPK cascade","15/143","237/18670",{"v":4.16414710196616e-10,"d":"4.16E-10"},{"v":1.09457580965968e-08,"d":"1.09E-08"},{"v":5.09488948224158e-09,"d":"5.09E-09"},"TLR4/MAPK1/TLR9/IGF1R/HMGCR/MAPK3/AKT1/PTPN1/TNF/HRAS/VEGFA/MAP3K9/FOXO1/PTPN22/IL1B",15]
["GO:0070302","regulation of stress-activated protein kinase signaling cascade","15/143","239/18670",{"v":4.68073787139204e-10,"d":"4.68E-10"},{"v":1.22242754215451e-08,"d":"1.22E-08"},{"v":5.68999714077538e-09,"d":"5.69E-09"},"TLR4/MAPK1/TLR9/IGF1R/HMGCR/MAPK3/AKT1/PTPN1/TNF/HRAS/VEGFA/MAP3K9/FOXO1/PTPN22/IL1B",15]
["GO:1903829","positive regulation of cellular protein localization","17/143","324/18670",{"v":4.89854029577623e-10,"d":"4.90E-10"},{"v":1.27110840495527e-08,"d":"1.27E-08"},{"v":5.91659050569464e-09,"d":"5.92E-09"},"GSK3B/MAPK14/PTGS2/MAPK1/MAPK8/F2/AKT1/PIK3R1/SHH/TNF/HRAS/AKT2/KCNJ11/EIF2AK3/TP53/PRKAA2/IL1B",17]
["GO:0019229","regulation of vasoconstriction","9/143","58/18670",{"v":5.44987767316415e-10,"d":"5.45E-10"},{"v":1.39627245702332e-08,"d":"1.40E-08"},{"v":6.49918789804386e-09,"d":"6.50E-09"},"PTGS2/HRH1/AKT1/AVPR2/AVPR1A/ACE/AGTR1/CASR/ICAM1",9]
["GO:0031663","lipopolysaccharide-mediated signaling pathway","9/143","58/18670",{"v":5.44987767316415e-10,"d":"5.45E-10"},{"v":1.39627245702332e-08,"d":"1.40E-08"},{"v":6.49918789804386e-09,"d":"6.50E-09"},"TLR4/MAPK14/MAPK1/MAPK3/AKT1/NOS3/TNF/PTPN22/IL1B",9]
["GO:0034614","cellular response to reactive oxygen species","13/143","168/18670",{"v":5.52891816698873e-10,"d":"5.53E-10"},{"v":1.40761388301701e-08,"d":"1.41E-08"},{"v":6.55197849646463e-09,"d":"6.55E-09"},"MAPK1/MAPK8/MMP9/MAPK3/AKT1/NOS3/MMP2/TNF/FOS/SIRT1/IL6/FOXO1/NFE2L2",13]
["GO:0035265","organ growth","14/143","204/18670",{"v":5.70573319539831e-10,"d":"5.71E-10"},{"v":1.44355049843577e-08,"d":"1.44E-08"},{"v":6.71925159194933e-09,"d":"6.72E-09"},"AR/MAPK14/MAPK1/FGFR1/MTOR/AKT1/CYP19A1/ESR1/PPARA/SHH/FGF2/PARP2/RBP4/ACACB",14]
["GO:0048708","astrocyte differentiation","10/143","81/18670",{"v":5.97795631611848e-10,"d":"5.98E-10"},{"v":1.49948687696633e-08,"d":"1.50E-08"},{"v":6.97961699024789e-09,"d":"6.98E-09"},"TLR4/BACE2/MAPK1/F2/MAPK3/STAT3/SHH/TNF/IL6/IL1B",10]
["GO:0009896","positive regulation of catabolic process","19/143","423/18670",{"v":6.00091092066565e-10,"d":"6.00E-10"},{"v":1.49948687696633e-08,"d":"1.50E-08"},{"v":6.97961699024789e-09,"d":"6.98E-09"},"GSK3B/INSR/MAPK3/AKT1/PTPN1/HK2/PPARA/TNF/AKT2/SIRT1/HMOX1/IL6/FOXO1/HIF1A/ADRB2/PRKAA2/FTO/NFE2L2/IL1B",19]
["GO:0050679","positive regulation of epithelial cell proliferation","14/143","206/18670",{"v":6.48565718490162e-10,"d":"6.49E-10"},{"v":1.61067118309704e-08,"d":"1.61E-08"},{"v":7.49714327476519e-09,"d":"7.50E-09"},"AR/FGFR1/MTOR/STAT3/AKT1/SHH/HRAS/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/PGF/AGTR1",14]
["GO:0046209","nitric oxide metabolic process","10/143","82/18670",{"v":6.76413665778229e-10,"d":"6.76E-10"},{"v":1.66958690187212e-08,"d":"1.67E-08"},{"v":7.77137651953164e-09,"d":"7.77E-09"},"TLR4/NOS2/PTGS2/MTOR/INSR/AKT1/NOS3/TNF/ICAM1/IL1B",10]
["GO:0010634","positive regulation of epithelial cell migration","13/143","171/18670",{"v":6.88358266657504e-10,"d":"6.88E-10"},{"v":1.67859895387324e-08,"d":"1.68E-08"},{"v":7.81332465007567e-09,"d":"7.81E-09"},"PTGS2/FGFR1/MMP9/MTOR/AKT1/NOS3/ALOX12/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/NFE2L2",13]
["GO:0016241","regulation of macroautophagy","13/143","171/18670",{"v":6.88358266657504e-10,"d":"6.88E-10"},{"v":1.67859895387324e-08,"d":"1.68E-08"},{"v":7.81332465007567e-09,"d":"7.81E-09"},"MAPK8/PIK3CA/MTOR/MAPK3/AKT1/CASP3/SIRT1/GAPDH/HMOX1/HIF1A/ADRB2/TP53/PRKAA2",13]
["GO:0050678","regulation of epithelial cell proliferation","18/143","378/18670",{"v":6.95964136230287e-10,"d":"6.96E-10"},{"v":1.68698372662288e-08,"d":"1.69E-08"},{"v":7.85235300253523e-09,"d":"7.85E-09"},"AR/FLT1/FGFR1/MTOR/STAT3/AKT1/VDR/PPARG/SHH/TNF/HRAS/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/PGF/AGTR1",18]
["GO:0002700","regulation of production of molecular mediator of immune response","12/143","139/18670",{"v":7.42419374953112e-10,"d":"7.42E-10"},{"v":1.77420655743819e-08,"d":"1.77E-08"},{"v":8.25834652021624e-09,"d":"8.26E-09"},"TLR4/MAPK14/TLR9/MAPK3/HK1/IL2/TNF/HMOX1/IL6/PRKCZ/RBP4/IL1B",12]
["GO:0007586","digestion","12/143","139/18670",{"v":7.42419374953112e-10,"d":"7.42E-10"},{"v":1.77420655743819e-08,"d":"1.77E-08"},{"v":8.25834652021624e-09,"d":"8.26E-09"},"TLR4/TLR9/KCNQ1/VDR/MGAM/FABP2/SGK1/SLC5A1/RBP4/CTRB1/AMY2A/SI",12]
["GO:0032147","activation of protein kinase activity","17/143","333/18670",{"v":7.45096627382639e-10,"d":"7.45E-10"},{"v":1.77420655743819e-08,"d":"1.77E-08"},{"v":8.25834652021624e-09,"d":"8.26E-09"},"TLR4/MAPK14/MAPK1/MAPK10/PIK3CA/MTOR/INSR/MAPK3/AKT1/PTPN1/TNF/VEGFA/FGF2/MAP3K9/PRKCZ/ADRB2/IL1B",17]
["GO:0045913","positive regulation of carbohydrate metabolic process","10/143","83/18670",{"v":7.64092457872934e-10,"d":"7.64E-10"},{"v":1.80879898799394e-08,"d":"1.81E-08"},{"v":8.41936287837829e-09,"d":"8.42E-09"},"GCK/INSR/HRH1/AKT1/PPARA/AKT2/SIRT1/FOXO1/HIF1A/PRKAA2",10]
["GO:0042180","cellular ketone metabolic process","15/143","248/18670",{"v":7.81589131501327e-10,"d":"7.82E-10"},{"v":1.83946093274266e-08,"d":"1.84E-08"},{"v":8.56208412109777e-09,"d":"8.56E-09"},"PTGS2/HMGCR/MTOR/AKT1/CYP19A1/CNR1/PPARG/AVPR1A/PPARA/AKR1B1/AKT2/SIRT1/PRKAA2/ACACB/IL1B",15]
["GO:0007596","blood coagulation","17/143","336/18670",{"v":8.54381191911691e-10,"d":"8.54E-10"},{"v":1.9819817456851e-08,"d":"1.98E-08"},{"v":9.22547151231623e-09,"d":"9.23E-09"},"TLR4/MAPK1/PIK3CA/PIK3CG/PRKCB/SELP/F2/MAPK3/NOS3/PIK3R1/ALOX12/PLAT/SHH/SERPINE1/HNF4A/IL6/NFE2L2",17]
["GO:0006631","fatty acid metabolic process","18/143","383/18670",{"v":8.58408335058024e-10,"d":"8.58E-10"},{"v":1.9819817456851e-08,"d":"1.98E-08"},{"v":9.22547151231623e-09,"d":"9.23E-09"},"MAPK14/PTGS2/MTOR/MAPK3/AKT1/CNR1/PPARG/ALOX12/AVPR1A/PPARA/PON1/AKT2/SIRT1/CYP3A4/LIPE/PRKAA2/ACACB/IL1B",18]
["GO:0045765","regulation of angiogenesis","18/143","383/18670",{"v":8.58408335058024e-10,"d":"8.58E-10"},{"v":1.9819817456851e-08,"d":"1.98E-08"},{"v":9.22547151231623e-09,"d":"9.23E-09"},"PTGS2/FLT1/PRKCB/STAT3/NOS3/PPARG/HK2/VEGFA/FGF2/SERPINE1/SIRT1/HMOX1/IL6/HIF1A/PGF/AGTR1/NFE2L2/IL1B",18]
["GO:0097756","negative regulation of blood vessel diameter","10/143","84/18670",{"v":8.61731193776131e-10,"d":"8.62E-10"},{"v":1.9819817456851e-08,"d":"1.98E-08"},{"v":9.22547151231623e-09,"d":"9.23E-09"},"PTGS2/HMGCR/HRH1/AKT1/AVPR2/AVPR1A/ACE/AGTR1/CASR/ICAM1",10]
["GO:0050727","regulation of inflammatory response","20/143","485/18670",{"v":9.04262173721869e-10,"d":"9.04E-10"},{"v":2.06805270012776e-08,"d":"2.07E-08"},{"v":9.62610342528782e-09,"d":"9.63E-09"},"TLR4/NOS2/MAPK14/PTGS2/MMP9/TLR9/PIK3CG/F2/CYP19A1/CNR1/ESR1/PPARG/PPARA/IL2/TNF/FABP4/SERPINE1/IL6/AGTR1/IL1B",20]
["GO:0048732","gland development","19/143","434/18670",{"v":9.2035978910458e-10,"d":"9.20E-10"},{"v":2.09304293612098e-08,"d":"2.09E-08"},{"v":9.74242473386871e-09,"d":"9.74E-09"},"AR/MAPK1/FGFR1/PIK3CA/INSR/MAPK3/AKT1/CYP19A1/ESR1/VDR/HK2/SHH/TNF/VEGFA/AKT2/HNF4A/HMOX1/HIF1A/GLI2",19]
["GO:2001057","reactive nitrogen species metabolic process","10/143","85/18670",{"v":9.7030403918967e-10,"d":"9.70E-10"},{"v":2.1942965087373102e-08,"d":"2.19E-08"},{"v":1.02137267283123e-08,"d":"1.02E-08"},"TLR4/NOS2/PTGS2/MTOR/INSR/AKT1/NOS3/TNF/ICAM1/IL1B",10]
["GO:0001938","positive regulation of endothelial cell proliferation","11/143","112/18670",{"v":9.78766778377453e-10,"d":"9.79E-10"},{"v":2.20113773270663e-08,"d":"2.20E-08"},{"v":1.02455703701499e-08,"d":"1.02E-08"},"FGFR1/MTOR/STAT3/AKT1/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/PGF/AGTR1",11]
["GO:0050817","coagulation","17/143","342/18670",{"v":1.118625842383e-09,"d":"1.12E-09"},{"v":2.50140861077233e-08,"d":"2.50E-08"},{"v":1.16432322999856e-08,"d":"1.16E-08"},"TLR4/MAPK1/PIK3CA/PIK3CG/PRKCB/SELP/F2/MAPK3/NOS3/PIK3R1/ALOX12/PLAT/SHH/SERPINE1/HNF4A/IL6/NFE2L2",17]
["GO:0045429","positive regulation of nitric oxide biosynthetic process","8/143","43/18670",{"v":1.12464517579191e-09,"d":"1.12E-09"},{"v":2.50140861077233e-08,"d":"2.50E-08"},{"v":1.16432322999856e-08,"d":"1.16E-08"},"TLR4/PTGS2/MTOR/INSR/AKT1/TNF/ICAM1/IL1B",8]
["GO:0006112","energy reserve metabolic process","10/143","87/18670",{"v":1.22455426419405e-09,"d":"1.22E-09"},{"v":2.70874079861067e-08,"d":"2.71E-08"},{"v":1.26082952712531e-08,"d":"1.26E-08"},"GSK3B/ADRB3/GCK/MTOR/INSR/AKT1/AKT2/GCGR/MC4R/GYS1",10]
["GO:0006096","glycolytic process","11/143","115/18670",{"v":1.30140355753669e-09,"d":"1.30E-09"},{"v":2.86308782658071e-08,"d":"2.86E-08"},{"v":1.3326729793997e-08,"d":"1.33E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:1904407","positive regulation of nitric oxide metabolic process","8/143","44/18670",{"v":1.36573827024519e-09,"d":"1.37E-09"},{"v":2.98838298267705e-08,"d":"2.99E-08"},{"v":1.39099374323693e-08,"d":"1.39E-08"},"TLR4/PTGS2/MTOR/INSR/AKT1/TNF/ICAM1/IL1B",8]
["GO:0044282","small molecule catabolic process","19/143","445/18670",{"v":1.39365593602038e-09,"d":"1.39E-09"},{"v":3.03307485430673e-08,"d":"3.03E-08"},{"v":1.41179633586672e-08,"d":"1.41E-08"},"NOS2/GCK/MTOR/AKT1/NOS3/CNR1/HK2/HK1/PPARA/ALDH2/PON1/FGF2/AKT2/GAPDH/LIPE/SORD/CYP26B1/TP53/ACACB",19]
["GO:0006757","ATP generation from ADP","11/143","116/18670",{"v":1.42841634299583e-09,"d":"1.43E-09"},{"v":3.09210126013216e-08,"d":"3.09E-08"},{"v":1.43927118151565e-08,"d":"1.44E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:0061041","regulation of wound healing","12/143","148/18670",{"v":1.53258068828476e-09,"d":"1.53E-09"},{"v":3.29993969477485e-08,"d":"3.30E-08"},{"v":1.53601311983747e-08,"d":"1.54E-08"},"TLR4/SELP/F2/HMGCR/MTOR/NOS3/ALOX12/PLAT/HRAS/FGF2/SERPINE1/NFE2L2",12]
["GO:0009314","response to radiation","19/143","448/18670",{"v":1.55731084589773e-09,"d":"1.56E-09"},{"v":3.33544672179577e-08,"d":"3.34E-08"},{"v":1.55254047015145e-08,"d":"1.55E-08"},"MAPK14/PTGS2/MAPK8/MAPK10/HMGCR/MTOR/NAMPT/CLK2/HRH1/AKT1/PIK3R1/CASP3/HRAS/AKT2/FOS/SIRT1/HIF1A/TP53/ICAM1",19]
["GO:1903037","regulation of leukocyte cell-cell adhesion","16/143","304/18670",{"v":1.56787131770555e-09,"d":"1.57E-09"},{"v":3.3403911021432e-08,"d":"3.34E-08"},{"v":1.55484191617337e-08,"d":"1.55E-08"},"PIK3CA/YES1/AKT1/PIK3R1/CASP3/PPARA/IL2/SHH/TNF/DPP4/IL6/PRKCZ/GLI2/PTPN22/ICAM1/IL1B",16]
["GO:0031330","negative regulation of cellular catabolic process","15/143","264/18670",{"v":1.84824806898259e-09,"d":"1.85E-09"},{"v":3.91712470326781e-08,"d":"3.92E-08"},{"v":1.82329239100515e-08,"d":"1.82E-08"},"MAPK14/PIK3CA/PIK3CG/MTOR/NAMPT/STAT3/AKT1/CNR1/PPARA/SHH/HMOX1/PTPN22/OGT/TP53/ACACB",15]
["GO:0042866","pyruvate biosynthetic process","11/143","119/18670",{"v":1.87879181117454e-09,"d":"1.88E-09"},{"v":3.961119401893e-08,"d":"3.96E-08"},{"v":1.84377047258905e-08,"d":"1.84E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:0097191","extrinsic apoptotic signaling pathway","14/143","224/18670",{"v":1.93453431831674e-09,"d":"1.93E-09"},{"v":4.0575103215265e-08,"d":"4.06E-08"},{"v":1.88863726740494e-08,"d":"1.89E-08"},"AR/GSK3B/FGFR1/AKT1/NOS3/PIK3R1/CASP3/IL2/TNF/SERPINE1/HMOX1/PARP2/ICAM1/IL1B",14]
["GO:0019319","hexose biosynthetic process","10/143","92/18670",{"v":2.13650745105625e-09,"d":"2.14E-09"},{"v":4.45803204220398e-08,"d":"4.46E-08"},{"v":2.07506692207851e-08,"d":"2.08E-08"},"GCK/CLK2/PPARA/AKR1B1/SIRT1/GAPDH/FOXO1/SORD/OGT/RBP4",10]
["GO:0030168","platelet activation","12/143","153/18670",{"v":2.24448117923856e-09,"d":"2.24E-09"},{"v":4.63554072120289e-08,"d":"4.64E-08"},{"v":2.15769135920355e-08,"d":"2.16E-08"},"TLR4/MAPK1/PIK3CA/PIK3CG/PRKCB/SELP/F2/MAPK3/NOS3/PIK3R1/ALOX12/IL6",12]
["GO:0050729","positive regulation of inflammatory response","12/143","153/18670",{"v":2.24448117923856e-09,"d":"2.24E-09"},{"v":4.63554072120289e-08,"d":"4.64E-08"},{"v":2.15769135920355e-08,"d":"2.16E-08"},"TLR4/PTGS2/TLR9/PIK3CG/CNR1/IL2/TNF/FABP4/SERPINE1/IL6/AGTR1/IL1B",12]
["GO:0046320","regulation of fatty acid oxidation","7/143","30/18670",{"v":2.34392380357077e-09,"d":"2.34E-09"},{"v":4.81634698317485e-08,"d":"4.82E-08"},{"v":2.24185071247217e-08,"d":"2.24E-08"},"MTOR/AKT1/CNR1/PPARG/PPARA/AKT2/ACACB",7]
["GO:1903409","reactive oxygen species biosynthetic process","11/143","122/18670",{"v":2.45236663678999e-09,"d":"2.45E-09"},{"v":5.0137273463262e-08,"d":"5.01E-08"},{"v":2.33372476334613e-08,"d":"2.33E-08"},"TLR4/NOS2/PTGS2/MTOR/INSR/STAT3/AKT1/NOS3/TNF/ICAM1/IL1B",11]
["GO:1901617","organic hydroxy compound biosynthetic process","15/143","271/18670",{"v":2.64326710458295e-09,"d":"2.64E-09"},{"v":5.37685690419688e-08,"d":"5.38E-08"},{"v":2.50274959915551e-08,"d":"2.50E-08"},"HMGCR/HRH1/CYP19A1/VDR/ALOX12/AKR1B1/TNF/CFTR/FGF2/SIRT1/CYP3A4/TP53/PRKAA2/ACACB/IL1B",15]
["GO:0042594","response to starvation","13/143","191/18670",{"v":2.67632404468537e-09,"d":"2.68E-09"},{"v":5.41687986644318e-08,"d":"5.42E-08"},{"v":2.52137896841411e-08,"d":"2.52E-08"},"MAPK1/MAPK8/MTOR/MAPK3/PPARG/SLC2A1/GCGR/SIRT1/FOXO1/EIF2AK3/TP53/PRKAA2/NFE2L2",13]
["GO:2001234","negative regulation of apoptotic signaling pathway","14/143","230/18670",{"v":2.72364045150973e-09,"d":"2.72E-09"},{"v":5.4852221630405e-08,"d":"5.49E-08"},{"v":2.55319005404683e-08,"d":"2.55E-08"},"AR/PTGS2/MMP9/AKT1/NOS3/PTPN1/TNF/SERPINE1/SIRT1/HMOX1/HIF1A/ICAM1/NFE2L2/IL1B",14]
["GO:0042110","T cell activation","19/143","464/18670",{"v":2.77426837935806e-09,"d":"2.77E-09"},{"v":5.55952396021854e-08,"d":"5.56E-08"},{"v":2.58777509069877e-08,"d":"2.59E-08"},"PIK3CA/PIK3CG/MTOR/STAT3/YES1/AKT1/PIK3R1/CASP3/IL2/SHH/DPP4/IL6/PRKCZ/GLI2/PTPN22/CYP26B1/TP53/ICAM1/IL1B",19]
["GO:0043535","regulation of blood vessel endothelial cell migration","12/143","156/18670",{"v":2.80301078515342e-09,"d":"2.80E-09"},{"v":5.58945204842415e-08,"d":"5.59E-08"},{"v":2.60170562894717e-08,"d":"2.60E-08"},"PTGS2/FGFR1/AKT1/NOS3/PPARG/ALOX12/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/NFE2L2",12]
["GO:0002702","positive regulation of production of molecular mediator of immune response","10/143","95/18670",{"v":2.93628614980991e-09,"d":"2.94E-09"},{"v":5.82651290903457e-08,"d":"5.83E-08"},{"v":2.71204964301328e-08,"d":"2.71E-08"},"TLR4/MAPK14/TLR9/MAPK3/HK1/IL2/IL6/PRKCZ/RBP4/IL1B",10]
["GO:0031998","regulation of fatty acid beta-oxidation","6/143","18/18670",{"v":3.12710530334933e-09,"d":"3.13E-09"},{"v":6.17488891119906e-08,"d":"6.17E-08"},{"v":2.8742071851067e-08,"d":"2.87E-08"},"MTOR/AKT1/CNR1/PPARA/AKT2/ACACB",6]
["GO:0097305","response to alcohol","14/143","233/18670",{"v":3.21940685874513e-09,"d":"3.22E-09"},{"v":6.32629075932053e-08,"d":"6.33E-08"},{"v":2.94467975327225e-08,"d":"2.94E-08"},"HMGCR/STAT3/AKT1/CNR1/PPARG/AVPR1A/IL2/CFTR/FOS/SETD7/RBP4/ICAM1/PRKAA2/CCR5",14]
["GO:0048010","vascular endothelial growth factor receptor signaling pathway","10/143","96/18670",{"v":3.25649066951678e-09,"d":"3.26E-09"},{"v":6.36824842038837e-08,"d":"6.37E-08"},{"v":2.96420966103994e-08,"d":"2.96E-08"},"MAPK14/FLT1/PIK3CA/PRKCB/PIK3R1/PTPN1/VEGFA/HIF1A/PGF/IL1B",10]
["GO:0003044","regulation of systemic arterial blood pressure mediated by a chemical signal","8/143","49/18670",{"v":3.36503553137126e-09,"d":"3.37E-09"},{"v":6.54887684182254e-08,"d":"6.55E-08"},{"v":3.04828623540211e-08,"d":"3.05E-08"},"REN/ADRB3/NOS3/AVPR2/AVPR1A/ACE/AGTR1/ADRB2",8]
["GO:0071453","cellular response to oxygen levels","14/143","234/18670",{"v":3.40209004427431e-09,"d":"3.40E-09"},{"v":6.58931124364709e-08,"d":"6.59E-08"},{"v":3.06710711621809e-08,"d":"3.07E-08"},"PTGS2/MTOR/NAMPT/AKT1/PPARG/VEGFA/SIRT1/HMOX1/FOXO1/HIF1A/CASR/TP53/ICAM1/NFE2L2",14]
["GO:0046031","ADP metabolic process","11/143","126/18670",{"v":3.45931628461e-09,"d":"3.46E-09"},{"v":6.66824396195299e-08,"d":"6.67E-08"},{"v":3.10384769396085e-08,"d":"3.10E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:0015908","fatty acid transport","10/143","97/18670",{"v":3.60728976490272e-09,"d":"3.61E-09"},{"v":6.9205255774058e-08,"d":"6.92E-08"},{"v":3.22127646753598e-08,"d":"3.22E-08"},"NOS2/AKT1/PPARG/PPARA/FABP4/AKT2/ACE/PRKAA2/ACACB/IL1B",10]
["GO:0035270","endocrine system development","11/143","127/18670",{"v":3.7627917661323e-09,"d":"3.76E-09"},{"v":7.18480239118092e-08,"d":"7.18E-08"},{"v":3.3442886104155e-08,"d":"3.34E-08"},"GSK3B/MAPK1/INSR/MAPK3/AKT1/SHH/HNF4A/IL6/FOXO1/EIF2AK3/GLI2",11]
["GO:0045907","positive regulation of vasoconstriction","7/143","32/18670",{"v":3.82608967185309e-09,"d":"3.83E-09"},{"v":7.27136666275179e-08,"d":"7.27E-08"},{"v":3.38458142456982e-08,"d":"3.38E-08"},"PTGS2/HRH1/AKT1/AVPR2/AVPR1A/CASR/ICAM1",7]
["GO:0009749","response to glucose","13/143","197/18670",{"v":3.89811639831076e-09,"d":"3.90E-09"},{"v":7.37363326185137e-08,"d":"7.37E-08"},{"v":3.43218315443987e-08,"d":"3.43E-08"},"PIK3CA/IGF1R/GCK/HMGCR/CASP3/CFTR/HNF4A/KCNJ11/HIF1A/CASR/NR0B2/ICAM1/PRKAA2",13]
["GO:1901342","regulation of vasculature development","18/143","422/18670",{"v":3.97279113444241e-09,"d":"3.97E-09"},{"v":7.47993419173157e-08,"d":"7.48E-08"},{"v":3.48166273226532e-08,"d":"3.48E-08"},"PTGS2/FLT1/PRKCB/STAT3/NOS3/PPARG/HK2/VEGFA/FGF2/SERPINE1/SIRT1/HMOX1/IL6/HIF1A/PGF/AGTR1/NFE2L2/IL1B",18]
["GO:0010595","positive regulation of endothelial cell migration","11/143","128/18670",{"v":4.08986036320188e-09,"d":"4.09E-09"},{"v":7.66470127325981e-08,"d":"7.66E-08"},{"v":3.56766571643828e-08,"d":"3.57E-08"},"PTGS2/FGFR1/AKT1/NOS3/ALOX12/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/NFE2L2",11]
["GO:0030258","lipid modification","14/143","238/18670",{"v":4.231160160781e-09,"d":"4.23E-09"},{"v":7.89296605107902e-08,"d":"7.89E-08"},{"v":3.67391544399611e-08,"d":"3.67E-08"},"MAPK14/PIK3CA/PIK3CG/MTOR/AKT1/PIK3R1/CNR1/PPARG/ALOX12/PPARA/AKT2/CYP3A4/AGTR1/ACACB",14]
["GO:0046677","response to antibiotic","16/143","327/18670",{"v":4.46541940287534e-09,"d":"4.47E-09"},{"v":8.29175125818321e-08,"d":"8.29E-08"},{"v":3.85953680885894e-08,"d":"3.86E-08"},"HMGCR/STAT3/CNR1/CASP3/IL2/CFTR/SIRT1/SETD7/HMOX1/AOC3/IL6/FOXO1/TP53/RBP4/ICAM1/NFE2L2",16]
["GO:1903524","positive regulation of blood circulation","9/143","73/18670",{"v":4.50848053107748e-09,"d":"4.51E-09"},{"v":8.33348364831126e-08,"d":"8.33E-08"},{"v":3.87896186043196e-08,"d":"3.88E-08"},"PTGS2/HRH1/KCNQ1/AKT1/AVPR2/AVPR1A/CASR/ICAM1/ATP2A1",9]
["GO:0001655","urogenital system development","16/143","330/18670",{"v":5.08598804226549e-09,"d":"5.09E-09"},{"v":9.3582179977685e-08,"d":"9.36E-08"},{"v":4.35594191179676e-08,"d":"4.36E-08"},"AR/FGFR1/MMP9/REN/CYP19A1/ESR1/AKR1B1/SHH/VEGFA/FGF2/ACE/PGF/GLI2/AGTR1/CYP26B1/RBP4",16]
["GO:0009266","response to temperature stimulus","14/143","243/18670",{"v":5.52462071010633e-09,"d":"5.52E-09"},{"v":1.01193052644844e-07,"d":"1.01E-07"},{"v":4.71020293931428e-08,"d":"4.71E-08"},"GSK3B/PTGS2/MAPK1/MTOR/MAPK3/AKT1/NOS3/PPARG/FOS/SIRT1/HMOX1/FOXO1/EIF2AK3/ADRB2",14]
["GO:0006073","cellular glucan metabolic process","9/143","75/18670",{"v":5.75759845411792e-09,"d":"5.76E-09"},{"v":1.04514612297172e-07,"d":"1.05E-07"},{"v":4.86481058903521e-08,"d":"4.86E-08"},"GSK3B/GCK/MTOR/INSR/AKT1/MGAM/AKT2/GCGR/GYS1",9]
["GO:0044042","glucan metabolic process","9/143","75/18670",{"v":5.75759845411792e-09,"d":"5.76E-09"},{"v":1.04514612297172e-07,"d":"1.05E-07"},{"v":4.86481058903521e-08,"d":"4.86E-08"},"GSK3B/GCK/MTOR/INSR/AKT1/MGAM/AKT2/GCGR/GYS1",9]
["GO:0016042","lipid catabolic process","16/143","333/18670",{"v":5.78477092453462e-09,"d":"5.78E-09"},{"v":1.04539074564804e-07,"d":"1.05E-07"},{"v":4.86594922693467e-08,"d":"4.87E-08"},"PIK3CG/MTOR/AKT1/CYP19A1/CNR1/PPARA/TNF/FABP4/FABP2/AKT2/CYP3A4/LIPE/CYP26B1/ACACB/HCAR2/IL1B",16]
["GO:0002367","cytokine production involved in immune response","10/143","102/18670",{"v":5.91443743322595e-09,"d":"5.91E-09"},{"v":1.06407301020883e-07,"d":"1.06E-07"},{"v":4.9529090084091e-08,"d":"4.95E-08"},"TLR4/MAPK14/MAPK3/HK1/TNF/SIRT1/HMOX1/IL6/PRKCZ/IL1B",10]
["GO:0034764","positive regulation of transmembrane transport","13/143","204/18670",{"v":5.94784551095426e-09,"d":"5.95E-09"},{"v":1.06534861187358e-07,"d":"1.07E-07"},{"v":4.95884651355758e-08,"d":"4.96E-08"},"BRAF/MAPK14/F2/INSR/KCNQ1/AKT1/PIK3R1/CFTR/AKT2/KCNJ11/ADRB2/NFE2L2/ATP2A1",13]
["GO:0097193","intrinsic apoptotic signaling pathway","15/143","289/18670",{"v":6.32676420221565e-09,"d":"6.33E-09"},{"v":1.12822649738189e-07,"d":"1.13E-07"},{"v":5.251522338032e-08,"d":"5.25E-08"},"PTGS2/MMP9/AKT1/PIK3R1/PTPN1/CASP3/TNF/HRAS/SIRT1/HMOX1/HIF1A/EIF2AK3/TP53/NFE2L2/ATP2A1",15]
["GO:0042310","vasoconstriction","9/143","76/18670",{"v":6.48885393687733e-09,"d":"6.49E-09"},{"v":1.15205617265261e-07,"d":"1.15E-07"},{"v":5.36244161911839e-08,"d":"5.36E-08"},"PTGS2/HRH1/AKT1/AVPR2/AVPR1A/ACE/AGTR1/CASR/ICAM1",9]
["GO:0042063","gliogenesis","15/143","290/18670",{"v":6.62868348600704e-09,"d":"6.63E-09"},{"v":1.16427737298572e-07,"d":"1.16E-07"},{"v":5.41932727700342e-08,"d":"5.42E-08"},"TLR4/BACE2/MAPK1/F2/MTOR/MAPK3/STAT3/AKT1/PPARG/HDAC11/SHH/TNF/AKT2/IL6/IL1B",15]
["GO:0048545","response to steroid hormone","17/143","385/18670",{"v":6.64160914807617e-09,"d":"6.64E-09"},{"v":1.16427737298572e-07,"d":"1.16E-07"},{"v":5.41932727700342e-08,"d":"5.42E-08"},"AR/PTGS2/ESR1/VDR/PPARG/CASP3/AVPR1A/PPARA/TNF/FOS/HNF4A/SIRT1/IL6/FOXO1/RXRG/NR0B2/ICAM1",17]
["GO:0006165","nucleoside diphosphate phosphorylation","11/143","134/18670",{"v":6.64397413932067e-09,"d":"6.64E-09"},{"v":1.16427737298572e-07,"d":"1.16E-07"},{"v":5.41932727700342e-08,"d":"5.42E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:0070873","regulation of glycogen metabolic process","7/143","35/18670",{"v":7.49892405380196e-09,"d":"7.50E-09"},{"v":1.30604950686971e-07,"d":"1.31E-07"},{"v":6.07922981406487e-08,"d":"6.08E-08"},"GSK3B/GCK/MTOR/INSR/AKT1/AKT2/GCGR",7]
["GO:1904645","response to amyloid-beta","8/143","54/18670",{"v":7.51752804102379e-09,"d":"7.52E-09"},{"v":1.30604950686971e-07,"d":"1.31E-07"},{"v":6.07922981406487e-08,"d":"6.08E-08"},"GSK3B/TLR4/MMP9/IGF1R/NAMPT/MMP2/ADRB2/ICAM1",8]
["GO:0046939","nucleotide phosphorylation","11/143","136/18670",{"v":7.76814602394031e-09,"d":"7.77E-09"},{"v":1.34382286773121e-07,"d":"1.34E-07"},{"v":6.25505235396003e-08,"d":"6.26E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:0009206","purine ribonucleoside triphosphate biosynthetic process","12/143","171/18670",{"v":7.95411007036834e-09,"d":"7.95E-09"},{"v":1.37013776871707e-07,"d":"1.37E-07"},{"v":6.37753954130317e-08,"d":"6.38E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0006914","autophagy","19/143","496/18670",{"v":8.21619675519881e-09,"d":"8.22E-09"},{"v":1.4033402727867e-07,"d":"1.40E-07"},{"v":6.5320862499693e-08,"d":"6.53E-08"},"GSK3B/MAPK8/PIK3CA/MTOR/MAPK3/NAMPT/STAT3/AKT1/CASP3/HK2/SIRT1/GAPDH/HMOX1/FOXO1/HIF1A/PTPN22/ADRB2/TP53/PRKAA2",19]
["GO:0061919","process utilizing autophagic mechanism","19/143","496/18670",{"v":8.21619675519881e-09,"d":"8.22E-09"},{"v":1.4033402727867e-07,"d":"1.40E-07"},{"v":6.5320862499693e-08,"d":"6.53E-08"},"GSK3B/MAPK8/PIK3CA/MTOR/MAPK3/NAMPT/STAT3/AKT1/CASP3/HK2/SIRT1/GAPDH/HMOX1/FOXO1/HIF1A/PTPN22/ADRB2/TP53/PRKAA2",19]
["GO:0009145","purine nucleoside triphosphate biosynthetic process","12/143","172/18670",{"v":8.49518254373408e-09,"d":"8.50E-09"},{"v":1.44489491332082e-07,"d":"1.44E-07"},{"v":6.72550939994869e-08,"d":"6.73E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0042136","neurotransmitter biosynthetic process","10/143","106/18670",{"v":8.6176587313114e-09,"d":"8.62E-09"},{"v":1.45959341189743e-07,"d":"1.46E-07"},{"v":6.7939260643239e-08,"d":"6.79E-08"},"TLR4/NOS2/PTGS2/MTOR/INSR/AKT1/NOS3/TNF/ICAM1/IL1B",10]
["GO:0009135","purine nucleoside diphosphate metabolic process","11/143","138/18670",{"v":9.05922956071741e-09,"d":"9.06E-09"},{"v":1.52164984488731e-07,"d":"1.52E-07"},{"v":7.08277829818046e-08,"d":"7.08E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:0009179","purine ribonucleoside diphosphate metabolic process","11/143","138/18670",{"v":9.05922956071741e-09,"d":"9.06E-09"},{"v":1.52164984488731e-07,"d":"1.52E-07"},{"v":7.08277829818046e-08,"d":"7.08E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:1903522","regulation of blood circulation","15/143","297/18670",{"v":9.13898109342108e-09,"d":"9.14E-09"},{"v":1.52870229199044e-07,"d":"1.53E-07"},{"v":7.11560511405991e-08,"d":"7.12E-08"},"PTGS2/PIK3CG/HRH1/KCNQ1/AKT1/NOS3/AVPR2/AVPR1A/IL2/ACE/KCNJ11/AGTR1/CASR/ICAM1/ATP2A1",15]
["GO:0006164","purine nucleotide biosynthetic process","15/143","300/18670",{"v":1.04591508702053e-08,"d":"1.05E-08"},{"v":1.74233097623831e-07,"d":"1.74E-07"},{"v":8.10997619998589e-08,"d":"8.11E-08"},"NOS2/GCK/INSR/STAT3/NOS3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2/ACACB",15]
["GO:0009185","ribonucleoside diphosphate metabolic process","11/143","140/18670",{"v":1.05386006217985e-08,"d":"1.05E-08"},{"v":1.74758843461599e-07,"d":"1.75E-07"},{"v":8.13444793520548e-08,"d":"8.13E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:0007254","JNK cascade","13/143","214/18670",{"v":1.05770545079278e-08,"d":"1.06E-08"},{"v":1.74758843461599e-07,"d":"1.75E-07"},{"v":8.13444793520548e-08,"d":"8.13E-08"},"TLR4/MAPK8/MAPK10/TLR9/IGF1R/AKT1/PTPN1/TNF/HRAS/MAP3K9/PTPN22/CASR/IL1B",13]
["GO:0038083","peptidyl-tyrosine autophosphorylation","7/143","37/18670",{"v":1.13353979049928e-08,"d":"1.13E-08"},{"v":1.85772027204092e-07,"d":"1.86E-07"},{"v":8.64707532492523e-08,"d":"8.65E-08"},"IGF1R/INSR/MAPK3/BLK/YES1/VEGFA/ACE",7]
["GO:0071276","cellular response to cadmium ion","7/143","37/18670",{"v":1.13353979049928e-08,"d":"1.13E-08"},{"v":1.85772027204092e-07,"d":"1.86E-07"},{"v":8.64707532492523e-08,"d":"8.65E-08"},"MAPK1/MAPK8/MMP9/MAPK3/AKT1/FOS/HMOX1",7]
["GO:1903428","positive regulation of reactive oxygen species biosynthetic process","8/143","57/18670",{"v":1.1710475257981e-08,"d":"1.17E-08"},{"v":1.90695308255497e-07,"d":"1.91E-07"},{"v":8.87623782445756e-08,"d":"8.88E-08"},"TLR4/PTGS2/MTOR/INSR/AKT1/TNF/ICAM1/IL1B",8]
["GO:0009201","ribonucleoside triphosphate biosynthetic process","12/143","177/18670",{"v":1.17300226669019e-08,"d":"1.17E-08"},{"v":1.90695308255497e-07,"d":"1.91E-07"},{"v":8.87623782445756e-08,"d":"8.88E-08"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0010631","epithelial cell migration","16/143","351/18670",{"v":1.21815387683985e-08,"d":"1.22E-08"},{"v":1.97243475737908e-07,"d":"1.97E-07"},{"v":9.18103342965612e-08,"d":"9.18E-08"},"PTGS2/FGFR1/MMP9/PIK3CA/MTOR/AKT1/NOS3/PPARG/ALOX12/VEGFA/FGF2/SIRT1/DPP4/HMOX1/HIF1A/NFE2L2",16]
["GO:0060326","cell chemotaxis","15/143","304/18670",{"v":1.24901176476375e-08,"d":"1.25E-08"},{"v":2.01434247958711e-07,"d":"2.01E-07"},{"v":9.37610005840683e-08,"d":"9.38E-08"},"MAPK14/FLT1/FGFR1/PIK3CG/MAPK3/HRH1/CYP19A1/VEGFA/FGF2/SERPINE1/IL6/PGF/AGTR1/CCR5/IL1B",15]
["GO:0006732","coenzyme metabolic process","17/143","403/18670",{"v":1.30651510278438e-08,"d":"1.31E-08"},{"v":2.09871949844093e-07,"d":"2.10E-07"},{"v":9.76884725974951e-08,"d":"9.77E-08"},"PTGS2/GCK/HMGCR/INSR/NAMPT/STAT3/SLC2A1/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2/ACACB/TKT",17]
["GO:0030879","mammary gland development","11/143","143/18670",{"v":1.31631765935799e-08,"d":"1.32E-08"},{"v":2.10397974756197e-07,"d":"2.10E-07"},{"v":9.79333198495923e-08,"d":"9.79E-08"},"AR/MAPK1/AKT1/CYP19A1/ESR1/VDR/HK2/VEGFA/AKT2/HIF1A/GLI2",11]
["GO:1903039","positive regulation of leukocyte cell-cell adhesion","13/143","218/18670",{"v":1.320184920654e-08,"d":"1.32E-08"},{"v":2.10397974756197e-07,"d":"2.10E-07"},{"v":9.79333198495923e-08,"d":"9.79E-08"},"PIK3CA/YES1/AKT1/PIK3R1/IL2/SHH/TNF/DPP4/IL6/PRKCZ/GLI2/ICAM1/IL1B",13]
["GO:1903034","regulation of response to wounding","12/143","179/18670",{"v":1.33073775159116e-08,"d":"1.33E-08"},{"v":2.11248094840824e-07,"d":"2.11E-07"},{"v":9.83290227181911e-08,"d":"9.83E-08"},"TLR4/SELP/F2/HMGCR/MTOR/NOS3/ALOX12/PLAT/HRAS/FGF2/SERPINE1/NFE2L2",12]
["GO:0009108","coenzyme biosynthetic process","14/143","261/18670",{"v":1.37272566450761e-08,"d":"1.37E-08"},{"v":2.16270776240703e-07,"d":"2.16E-07"},{"v":1.00666915298226e-07,"d":"1.01E-07"},"PTGS2/GCK/INSR/NAMPT/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2/ACACB",14]
["GO:0090132","epithelium migration","16/143","354/18670",{"v":1.37306298156771e-08,"d":"1.37E-08"},{"v":2.16270776240703e-07,"d":"2.16E-07"},{"v":1.00666915298226e-07,"d":"1.01E-07"},"PTGS2/FGFR1/MMP9/PIK3CA/MTOR/AKT1/NOS3/PPARG/ALOX12/VEGFA/FGF2/SIRT1/DPP4/HMOX1/HIF1A/NFE2L2",16]
["GO:0007584","response to nutrient","13/143","219/18670",{"v":1.39439189308646e-08,"d":"1.39E-08"},{"v":2.18779007101318e-07,"d":"2.19E-07"},{"v":1.01834414060578e-07,"d":"1.02E-07"},"PTGS2/HMGCR/MTOR/CNR1/VDR/PPARG/GCGR/HMOX1/KCNJ11/OGT/CASR/CYP26B1/IL1B",13]
["GO:0043534","blood vessel endothelial cell migration","12/143","180/18670",{"v":1.41653809844813e-08,"d":"1.42E-08"},{"v":2.21395607047028e-07,"d":"2.21E-07"},{"v":1.03052355058815e-07,"d":"1.03E-07"},"PTGS2/FGFR1/AKT1/NOS3/PPARG/ALOX12/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/NFE2L2",12]
["GO:0010565","regulation of cellular ketone metabolic process","12/143","181/18670",{"v":1.50727562880374e-08,"d":"1.51E-08"},{"v":2.34671220976828e-07,"d":"2.35E-07"},{"v":1.09231715609664e-07,"d":"1.09E-07"},"PTGS2/MTOR/AKT1/CNR1/PPARG/AVPR1A/PPARA/AKT2/SIRT1/PRKAA2/ACACB/IL1B",12]
["GO:0010518","positive regulation of phospholipase activity","8/143","59/18670",{"v":1.55138975542284e-08,"d":"1.55E-08"},{"v":2.40614012641826e-07,"d":"2.41E-07"},{"v":1.11997889179548e-07,"d":"1.12E-07"},"FLT1/FGFR1/ESR1/AVPR1A/HRAS/FGF2/PRKCZ/AGTR1",8]
["GO:0002718","regulation of cytokine production involved in immune response","9/143","84/18670",{"v":1.59209469016577e-08,"d":"1.59E-08"},{"v":2.44121185825418e-07,"d":"2.44E-07"},{"v":1.13630362655372e-07,"d":"1.14E-07"},"TLR4/MAPK14/MAPK3/HK1/TNF/HMOX1/IL6/PRKCZ/IL1B",9]
["GO:0050886","endocrine process","9/143","84/18670",{"v":1.59209469016577e-08,"d":"1.59E-08"},{"v":2.44121185825418e-07,"d":"2.44E-07"},{"v":1.13630362655372e-07,"d":"1.14E-07"},"FGFR1/REN/NOS3/AVPR2/AVPR1A/ACE/AGTR1/HCAR2/IL1B",9]
["GO:0060420","regulation of heart growth","9/143","84/18670",{"v":1.59209469016577e-08,"d":"1.59E-08"},{"v":2.44121185825418e-07,"d":"2.44E-07"},{"v":1.13630362655372e-07,"d":"1.14E-07"},"MAPK14/MAPK1/FGFR1/MTOR/PPARA/FGF2/PARP2/RBP4/ACACB",9]
["GO:0009166","nucleotide catabolic process","12/143","182/18670",{"v":1.60319990950182e-08,"d":"1.60E-08"},{"v":2.44262254573275e-07,"d":"2.44E-07"},{"v":1.13696025506075e-07,"d":"1.14E-07"},"GCK/INSR/STAT3/PDE7A/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0046620","regulation of organ growth","10/143","113/18670",{"v":1.60508299694889e-08,"d":"1.61E-08"},{"v":2.44262254573275e-07,"d":"2.44E-07"},{"v":1.13696025506075e-07,"d":"1.14E-07"},"MAPK14/MAPK1/FGFR1/MTOR/AKT1/PPARA/FGF2/PARP2/RBP4/ACACB",10]
["GO:0046394","carboxylic acid biosynthetic process","18/143","462/18670",{"v":1.61789972957271e-08,"d":"1.62E-08"},{"v":2.45290565741959e-07,"d":"2.45E-07"},{"v":1.14174670448853e-07,"d":"1.14E-07"},"PTGS2/GCK/INSR/STAT3/ALOX12/HK2/HK1/AVPR1A/PPARA/SIRT1/GAPDH/CYP3A4/HIF1A/OGT/TP53/PRKAA2/ACACB/IL1B",18]
["GO:0016053","organic acid biosynthetic process","18/143","463/18670",{"v":1.67251120547156e-08,"d":"1.67E-08"},{"v":2.52624080587644e-07,"d":"2.53E-07"},{"v":1.17588179803381e-07,"d":"1.18E-07"},"PTGS2/GCK/INSR/STAT3/ALOX12/HK2/HK1/AVPR1A/PPARA/SIRT1/GAPDH/CYP3A4/HIF1A/OGT/TP53/PRKAA2/ACACB/IL1B",18]
["GO:0009127","purine nucleoside monophosphate biosynthetic process","12/143","183/18670",{"v":1.70457134682453e-08,"d":"1.70E-08"},{"v":2.5555943747947e-07,"d":"2.56E-07"},{"v":1.18954491649743e-07,"d":"1.19E-07"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0009168","purine ribonucleoside monophosphate biosynthetic process","12/143","183/18670",{"v":1.70457134682453e-08,"d":"1.70E-08"},{"v":2.5555943747947e-07,"d":"2.56E-07"},{"v":1.18954491649743e-07,"d":"1.19E-07"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0045444","fat cell differentiation","13/143","223/18670",{"v":1.73041732605105e-08,"d":"1.73E-08"},{"v":2.5847709726401e-07,"d":"2.58E-07"},{"v":1.20312566076185e-07,"d":"1.20E-07"},"MAPK14/PTGS2/MTOR/AKT1/PPARG/TNF/FABP4/AKT2/SIRT1/IL6/FOXO1/ADRB2/FTO",13]
["GO:0090130","tissue migration","16/143","360/18670",{"v":1.73824430522065e-08,"d":"1.74E-08"},{"v":2.58691652482837e-07,"d":"2.59E-07"},{"v":1.20412434456074e-07,"d":"1.20E-07"},"PTGS2/FGFR1/MMP9/PIK3CA/MTOR/AKT1/NOS3/PPARG/ALOX12/VEGFA/FGF2/SIRT1/DPP4/HMOX1/HIF1A/NFE2L2",16]
["GO:0042752","regulation of circadian rhythm","10/143","114/18670",{"v":1.74802747304974e-08,"d":"1.75E-08"},{"v":2.5919469637016e-07,"d":"2.59E-07"},{"v":1.20646584798883e-07,"d":"1.21E-07"},"GSK3B/MAPK8/MAPK10/MTOR/MTNR1B/PPARG/PPARA/HNF4A/TP53/PRKAA2",10]
["GO:0046324","regulation of glucose import","8/143","60/18670",{"v":1.77857536400199e-08,"d":"1.78E-08"},{"v":2.62761791002922e-07,"d":"2.63E-07"},{"v":1.22306949733522e-07,"d":"1.22E-07"},"MAPK14/INSR/AKT1/PIK3R1/HK2/TNF/AKT2/NFE2L2",8]
["GO:0072522","purine-containing compound biosynthetic process","15/143","313/18670",{"v":1.84372118719016e-08,"d":"1.84E-08"},{"v":2.71395758754391e-07,"d":"2.71E-07"},{"v":1.26325777036187e-07,"d":"1.26E-07"},"NOS2/GCK/INSR/STAT3/NOS3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2/ACACB",15]
["GO:0034637","cellular carbohydrate biosynthetic process","9/143","86/18670",{"v":1.9631742092543e-08,"d":"1.96E-08"},{"v":2.87932217357297e-07,"d":"2.88E-07"},{"v":1.34022953263356e-07,"d":"1.34E-07"},"GSK3B/GCK/MTOR/INSR/AKT1/SLC2A1/AKR1B1/AKT2/GYS1",9]
["GO:0009267","cellular response to starvation","11/143","149/18670",{"v":2.02221124151693e-08,"d":"2.02E-08"},{"v":2.95397416155795e-07,"d":"2.95E-07"},{"v":1.37497757155937e-07,"d":"1.37E-07"},"MAPK1/MAPK8/MTOR/MAPK3/SLC2A1/SIRT1/FOXO1/EIF2AK3/TP53/PRKAA2/NFE2L2",11]
["GO:0034404","nucleobase-containing small molecule biosynthetic process","13/143","226/18670",{"v":2.02866802597112e-08,"d":"2.03E-08"},{"v":2.95397416155795e-07,"d":"2.95E-07"},{"v":1.37497757155937e-07,"d":"1.37E-07"},"GCK/INSR/STAT3/PDE7A/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",13]
["GO:0045844","positive regulation of striated muscle tissue development","9/143","87/18670",{"v":2.17556483804294e-08,"d":"2.18E-08"},{"v":3.14460533705339e-07,"d":"3.14E-07"},{"v":1.46371009811878e-07,"d":"1.46E-07"},"MAPK14/MAPK1/FGFR1/HMGCR/MTOR/SHH/FGF2/PARP2/CYP26B1",9]
["GO:0048636","positive regulation of muscle organ development","9/143","87/18670",{"v":2.17556483804294e-08,"d":"2.18E-08"},{"v":3.14460533705339e-07,"d":"3.14E-07"},{"v":1.46371009811878e-07,"d":"1.46E-07"},"MAPK14/MAPK1/FGFR1/HMGCR/MTOR/SHH/FGF2/PARP2/CYP26B1",9]
["GO:0070371","ERK1 and ERK2 cascade","15/143","317/18670",{"v":2.18289056252965e-08,"d":"2.18E-08"},{"v":3.14460533705339e-07,"d":"3.14E-07"},{"v":1.46371009811878e-07,"d":"1.46E-07"},"BRAF/TLR4/MAPK1/FLT1/HMGCR/MAPK3/PTPN1/TNF/HRAS/FGF2/PRKCZ/PTPN22/CASR/ICAM1/IL1B",15]
["GO:1900371","regulation of purine nucleotide biosynthetic process","10/143","117/18670",{"v":2.24671998047382e-08,"d":"2.25E-08"},{"v":3.22507889395675e-07,"d":"3.23E-07"},{"v":1.50116788542297e-07,"d":"1.50E-07"},"NOS2/GCK/INSR/STAT3/NOS3/PPARA/HIF1A/OGT/TP53/PRKAA2",10]
["GO:0009142","nucleoside triphosphate biosynthetic process","12/143","188/18670",{"v":2.30305909616549e-08,"d":"2.30E-08"},{"v":3.28267014833729e-07,"d":"3.28E-07"},{"v":1.52797471539519e-07,"d":"1.53E-07"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:1901292","nucleoside phosphate catabolic process","12/143","188/18670",{"v":2.30305909616549e-08,"d":"2.30E-08"},{"v":3.28267014833729e-07,"d":"3.28E-07"},{"v":1.52797471539519e-07,"d":"1.53E-07"},"GCK/INSR/STAT3/PDE7A/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0010676","positive regulation of cellular carbohydrate metabolic process","8/143","62/18670",{"v":2.3202318323218e-08,"d":"2.32E-08"},{"v":3.28402043959393e-07,"d":"3.28E-07"},{"v":1.52860323145234e-07,"d":"1.53E-07"},"GCK/INSR/HRH1/AKT1/PPARA/AKT2/SIRT1/FOXO1",8]
["GO:0046824","positive regulation of nucleocytoplasmic transport","8/143","62/18670",{"v":2.3202318323218e-08,"d":"2.32E-08"},{"v":3.28402043959393e-07,"d":"3.28E-07"},{"v":1.52860323145234e-07,"d":"1.53E-07"},"GSK3B/MAPK14/PTGS2/MAPK1/PIK3R1/SHH/TP53/IL1B",8]
["GO:1901863","positive regulation of muscle tissue development","9/143","88/18670",{"v":2.40777676156864e-08,"d":"2.41E-08"},{"v":3.3902370431757e-07,"d":"3.39E-07"},{"v":1.57804355816635e-07,"d":"1.58E-07"},"MAPK14/MAPK1/FGFR1/HMGCR/MTOR/SHH/FGF2/PARP2/CYP26B1",9]
["GO:0050873","brown fat cell differentiation","7/143","41/18670",{"v":2.41285890734762e-08,"d":"2.41E-08"},{"v":3.3902370431757e-07,"d":"3.39E-07"},{"v":1.57804355816635e-07,"d":"1.58E-07"},"MAPK14/PTGS2/MTOR/FABP4/SIRT1/ADRB2/FTO",7]
["GO:0043542","endothelial cell migration","14/143","273/18670",{"v":2.42040144633838e-08,"d":"2.42E-08"},{"v":3.3902370431757e-07,"d":"3.39E-07"},{"v":1.57804355816635e-07,"d":"1.58E-07"},"PTGS2/FGFR1/PIK3CA/AKT1/NOS3/PPARG/ALOX12/VEGFA/FGF2/SIRT1/DPP4/HMOX1/HIF1A/NFE2L2",14]
["GO:0030808","regulation of nucleotide biosynthetic process","10/143","118/18670",{"v":2.4388583767975e-08,"d":"2.44E-08"},{"v":3.40430989975044e-07,"d":"3.40E-07"},{"v":1.58459400888114e-07,"d":"1.58E-07"},"NOS2/GCK/INSR/STAT3/NOS3/PPARA/HIF1A/OGT/TP53/PRKAA2",10]
["GO:0000187","activation of MAPK activity","11/143","152/18670",{"v":2.48828110850174e-08,"d":"2.49E-08"},{"v":3.44950750932023e-07,"d":"3.45E-07"},{"v":1.60563200584648e-07,"d":"1.61E-07"},"TLR4/MAPK14/MAPK1/MAPK10/INSR/MAPK3/PTPN1/TNF/FGF2/MAP3K9/IL1B",11]
["GO:0016202","regulation of striated muscle tissue development","11/143","152/18670",{"v":2.48828110850174e-08,"d":"2.49E-08"},{"v":3.44950750932023e-07,"d":"3.45E-07"},{"v":1.60563200584648e-07,"d":"1.61E-07"},"MAPK14/MAPK1/FGFR1/HMGCR/MTOR/PPARA/SHH/FGF2/PARP2/CYP26B1/RBP4",11]
["GO:0046622","positive regulation of organ growth","8/143","63/18670",{"v":2.64066317016245e-08,"d":"2.64E-08"},{"v":3.63585187510803e-07,"d":"3.64E-07"},{"v":1.69236916383487e-07,"d":"1.69E-07"},"MAPK14/MAPK1/FGFR1/MTOR/AKT1/FGF2/PARP2/ACACB",8]
["GO:0046686","response to cadmium ion","8/143","63/18670",{"v":2.64066317016245e-08,"d":"2.64E-08"},{"v":3.63585187510803e-07,"d":"3.64E-07"},{"v":1.69236916383487e-07,"d":"1.69E-07"},"MAPK1/MAPK8/MMP9/MAPK3/AKT1/FOS/HMOX1/SORD",8]
["GO:0006090","pyruvate metabolic process","11/143","154/18670",{"v":2.84994170585086e-08,"d":"2.85E-08"},{"v":3.91069966958789e-07,"d":"3.91E-07"},{"v":1.82030174967816e-07,"d":"1.82E-07"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:0010907","positive regulation of glucose metabolic process","7/143","42/18670",{"v":2.87700416418883e-08,"d":"2.88E-08"},{"v":3.93449758670148e-07,"d":"3.93E-07"},{"v":1.83137889541181e-07,"d":"1.83E-07"},"GCK/INSR/AKT1/PPARA/AKT2/SIRT1/FOXO1",7]
["GO:1901861","regulation of muscle tissue development","11/143","155/18670",{"v":3.04775168368896e-08,"d":"3.05E-08"},{"v":4.15397266517607e-07,"d":"4.15E-07"},{"v":1.93353730774526e-07,"d":"1.93E-07"},"MAPK14/MAPK1/FGFR1/HMGCR/MTOR/PPARA/SHH/FGF2/PARP2/CYP26B1/RBP4",11]
["GO:1901654","response to ketone","12/143","193/18670",{"v":3.08373617252477e-08,"d":"3.08E-08"},{"v":4.18891410281217e-07,"d":"4.19E-07"},{"v":1.94980139484964e-07,"d":"1.95E-07"},"AR/AKT1/PPARG/AVPR1A/AKR1B1/CFTR/FOS/SIRT1/KCNJ11/FOXO1/ICAM1/PRKAA2",12]
["GO:0051188","cofactor biosynthetic process","15/143","326/18670",{"v":3.16308004239883e-08,"d":"3.16E-08"},{"v":4.28232374970919e-07,"d":"4.28E-07"},{"v":1.99328050550745e-07,"d":"1.99E-07"},"PTGS2/GCK/INSR/NAMPT/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2/ACACB/NFE2L2",15]
["GO:0048634","regulation of muscle organ development","11/143","156/18670",{"v":3.25769621235731e-08,"d":"3.26E-08"},{"v":4.39571808920746e-07,"d":"4.40E-07"},{"v":2.04606183162091e-07,"d":"2.05E-07"},"MAPK14/MAPK1/FGFR1/HMGCR/MTOR/PPARA/SHH/FGF2/PARP2/CYP26B1/RBP4",11]
["GO:0032881","regulation of polysaccharide metabolic process","7/143","43/18670",{"v":3.41455353991846e-08,"d":"3.41E-08"},{"v":4.59206402976409e-07,"d":"4.59E-07"},{"v":2.13745439288478e-07,"d":"2.14E-07"},"GSK3B/GCK/MTOR/INSR/AKT1/AKT2/GCGR",7]
["GO:0002685","regulation of leukocyte migration","12/143","196/18670",{"v":3.65886622528831e-08,"d":"3.66E-08"},{"v":4.88814867325646e-07,"d":"4.89E-07"},{"v":2.27527203170612e-07,"d":"2.28E-07"},"MAPK14/SELP/MAPK3/AKT1/CYP19A1/TNF/VEGFA/SERPINE1/HMOX1/IL6/PGF/ICAM1",12]
["GO:0006694","steroid biosynthetic process","12/143","196/18670",{"v":3.65886622528831e-08,"d":"3.66E-08"},{"v":4.88814867325646e-07,"d":"4.89E-07"},{"v":2.27527203170612e-07,"d":"2.28E-07"},"HMGCR/HSD11B1/CYP19A1/VDR/AKR1B1/TNF/CFTR/SIRT1/CYP3A4/PRKAA2/ACACB/IL1B",12]
["GO:0051235","maintenance of location","15/143","330/18670",{"v":3.71548856481023e-08,"d":"3.72E-08"},{"v":4.93272200623743e-07,"d":"4.93E-07"},{"v":2.29601944850349e-07,"d":"2.30E-07"},"F2/AKT1/PPARG/HK2/HK1/PPARA/TNF/FGF2/SIRT1/IL6/CCR5/ACACB/FTO/ATP2A1/IL1B",15]
["GO:0009132","nucleoside diphosphate metabolic process","11/143","158/18670",{"v":3.71660131398818e-08,"d":"3.72E-08"},{"v":4.93272200623743e-07,"d":"4.93E-07"},{"v":2.29601944850349e-07,"d":"2.30E-07"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:0045428","regulation of nitric oxide biosynthetic process","8/143","66/18670",{"v":3.8412391638451e-08,"d":"3.84E-08"},{"v":5.08148239713888e-07,"d":"5.08E-07"},{"v":2.36526250542922e-07,"d":"2.37E-07"},"TLR4/PTGS2/MTOR/INSR/AKT1/TNF/ICAM1/IL1B",8]
["GO:0009156","ribonucleoside monophosphate biosynthetic process","12/143","197/18670",{"v":3.87091300920985e-08,"d":"3.87E-08"},{"v":5.10405728380505e-07,"d":"5.10E-07"},{"v":2.37577037081627e-07,"d":"2.38E-07"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0003073","regulation of systemic arterial blood pressure","9/143","93/18670",{"v":3.92426829276315e-08,"d":"3.92E-08"},{"v":5.14091846249361e-07,"d":"5.14E-07"},{"v":2.39292803408143e-07,"d":"2.39E-07"},"AR/REN/ADRB3/NOS3/AVPR2/AVPR1A/ACE/AGTR1/ADRB2",9]
["GO:1901655","cellular response to ketone","9/143","93/18670",{"v":3.92426829276315e-08,"d":"3.92E-08"},{"v":5.14091846249361e-07,"d":"5.14E-07"},{"v":2.39292803408143e-07,"d":"2.39E-07"},"AR/AKT1/PPARG/AKR1B1/CFTR/SIRT1/FOXO1/ICAM1/PRKAA2",9]
["GO:0010828","positive regulation of glucose transmembrane transport","7/143","44/18670",{"v":4.03471186397949e-08,"d":"4.03E-08"},{"v":5.26855278238354e-07,"d":"5.27E-07"},{"v":2.45233760153592e-07,"d":"2.45E-07"},"BRAF/MAPK14/INSR/AKT1/PIK3R1/AKT2/NFE2L2",7]
["GO:0015980","energy derivation by oxidation of organic compounds","14/143","285/18670",{"v":4.14798072348765e-08,"d":"4.15E-08"},{"v":5.39904371983216e-07,"d":"5.40E-07"},{"v":2.51307683027345e-07,"d":"2.51E-07"},"GSK3B/NOS2/PIK3CA/ADRB3/GCK/MTOR/INSR/AKT1/AKT2/GCGR/HIF1A/TP53/MC4R/GYS1",14]
["GO:0006754","ATP biosynthetic process","11/143","160/18670",{"v":4.23217858578606e-08,"d":"4.23E-08"},{"v":5.49098042155833e-07,"d":"5.49E-07"},{"v":2.55587033352127e-07,"d":"2.56E-07"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:0019932","second-messenger-mediated signaling","17/143","439/18670",{"v":4.56013774887412e-08,"d":"4.56E-08"},{"v":5.89758390014135e-07,"d":"5.90E-07"},{"v":2.7451308459676e-07,"d":"2.75E-07"},"GSK3B/NOS2/ADRB3/SELP/MTOR/MTNR1B/HRH1/NOS3/AVPR1A/TNF/VEGFA/GCGR/EIF2AK3/AGTR1/ADRB2/CCR5/MC4R",17]
["GO:0015718","monocarboxylic acid transport","11/143","162/18670",{"v":4.81044882419822e-08,"d":"4.81E-08"},{"v":6.20149580903006e-07,"d":"6.20E-07"},{"v":2.88659181874449e-07,"d":"2.89E-07"},"NOS2/AKT1/PPARG/PPARA/FABP4/AKT2/ACE/CASR/PRKAA2/ACACB/IL1B",11]
["GO:0019915","lipid storage","8/143","68/18670",{"v":4.88045497463801e-08,"d":"4.88E-08"},{"v":6.25192460042236e-07,"d":"6.25E-07"},{"v":2.91006475836177e-07,"d":"2.91E-07"},"PPARG/PPARA/TNF/SIRT1/IL6/ACACB/FTO/IL1B",8]
["GO:0046323","glucose import","8/143","68/18670",{"v":4.88045497463801e-08,"d":"4.88E-08"},{"v":6.25192460042236e-07,"d":"6.25E-07"},{"v":2.91006475836177e-07,"d":"2.91E-07"},"MAPK14/INSR/AKT1/PIK3R1/HK2/TNF/AKT2/NFE2L2",8]
["GO:0010632","regulation of epithelial cell migration","14/143","291/18670",{"v":5.37662403842373e-08,"d":"5.38E-08"},{"v":6.86579624843509e-07,"d":"6.87E-07"},{"v":3.1958017694765e-07,"d":"3.20E-07"},"PTGS2/FGFR1/MMP9/MTOR/AKT1/NOS3/PPARG/ALOX12/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/NFE2L2",14]
["GO:0005978","glycogen biosynthetic process","7/143","46/18670",{"v":5.56404270675587e-08,"d":"5.56E-08"},{"v":7.03851402404617e-07,"d":"7.04E-07"},{"v":3.27619619904375e-07,"d":"3.28E-07"},"GSK3B/GCK/MTOR/INSR/AKT1/AKT2/GYS1",7]
["GO:0009250","glucan biosynthetic process","7/143","46/18670",{"v":5.56404270675587e-08,"d":"5.56E-08"},{"v":7.03851402404617e-07,"d":"7.04E-07"},{"v":3.27619619904375e-07,"d":"3.28E-07"},"GSK3B/GCK/MTOR/INSR/AKT1/AKT2/GYS1",7]
["GO:0010883","regulation of lipid storage","7/143","46/18670",{"v":5.56404270675587e-08,"d":"5.56E-08"},{"v":7.03851402404617e-07,"d":"7.04E-07"},{"v":3.27619619904375e-07,"d":"3.28E-07"},"PPARG/PPARA/TNF/SIRT1/IL6/ACACB/FTO",7]
["GO:0046434","organophosphate catabolic process","13/143","248/18670",{"v":6.07095621146784e-08,"d":"6.07E-08"},{"v":7.65583512274823e-07,"d":"7.66E-07"},{"v":3.56353881571649e-07,"d":"3.56E-07"},"GCK/INSR/STAT3/PDE7A/HK2/HK1/PPARA/PON1/GAPDH/HIF1A/OGT/TP53/PRKAA2",13]
["GO:0010517","regulation of phospholipase activity","8/143","70/18670",{"v":6.15311259765023e-08,"d":"6.15E-08"},{"v":7.73534155133171e-07,"d":"7.74E-07"},{"v":3.60054643667666e-07,"d":"3.60E-07"},"FLT1/FGFR1/ESR1/AVPR1A/HRAS/FGF2/PRKCZ/AGTR1",8]
["GO:0006953","acute-phase response","7/143","47/18670",{"v":6.49615626991108e-08,"d":"6.50E-08"},{"v":8.14131287325079e-07,"d":"8.14E-07"},{"v":3.78951270103987e-07,"d":"3.79E-07"},"PTGS2/F2/STAT3/CNR1/TNF/IL6/IL1B",7]
["GO:0046887","positive regulation of hormone secretion","10/143","131/18670",{"v":6.63345499053137e-08,"d":"6.63E-08"},{"v":8.28772401286141e-07,"d":"8.29E-07"},{"v":3.85766225895099e-07,"d":"3.86E-07"},"FGFR1/GCK/BLK/CYP19A1/CFTR/HIF1A/CASR/NR0B2/RBP4/HCAR2",10]
["GO:0019395","fatty acid oxidation","9/143","99/18670",{"v":6.79356310563722e-08,"d":"6.79E-08"},{"v":8.46164413895983e-07,"d":"8.46E-07"},{"v":3.9386163430253e-07,"d":"3.94E-07"},"MAPK14/MTOR/AKT1/CNR1/PPARG/ALOX12/PPARA/AKT2/ACACB",9]
["GO:0009124","nucleoside monophosphate biosynthetic process","12/143","208/18670",{"v":7.04487965050239e-08,"d":"7.04E-08"},{"v":8.74775240037842e-07,"d":"8.75E-07"},{"v":4.07179030494003e-07,"d":"4.07E-07"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0045598","regulation of fat cell differentiation","10/143","132/18670",{"v":7.13072626948989e-08,"d":"7.13E-08"},{"v":8.8272721525673e-07,"d":"8.83E-07"},{"v":4.10880412759919e-07,"d":"4.11E-07"},"MAPK14/PTGS2/MTOR/AKT1/PPARG/TNF/SIRT1/IL6/FOXO1/FTO",10]
["GO:0005979","regulation of glycogen biosynthetic process","6/143","29/18670",{"v":7.46578347836293e-08,"d":"7.47E-08"},{"v":9.18586368401615e-07,"d":"9.19E-07"},{"v":4.27571666174041e-07,"d":"4.28E-07"},"GSK3B/GCK/MTOR/INSR/AKT1/AKT2",6]
["GO:0010962","regulation of glucan biosynthetic process","6/143","29/18670",{"v":7.46578347836293e-08,"d":"7.47E-08"},{"v":9.18586368401615e-07,"d":"9.19E-07"},{"v":4.27571666174041e-07,"d":"4.28E-07"},"GSK3B/GCK/MTOR/INSR/AKT1/AKT2",6]
["GO:0060193","positive regulation of lipase activity","8/143","72/18670",{"v":7.70148668784567e-08,"d":"7.70E-08"},{"v":9.41861574392727e-07,"d":"9.42E-07"},{"v":4.384055071154e-07,"d":"4.38E-07"},"FLT1/FGFR1/ESR1/AVPR1A/HRAS/FGF2/PRKCZ/AGTR1",8]
["GO:0061180","mammary gland epithelium development","8/143","72/18670",{"v":7.70148668784567e-08,"d":"7.70E-08"},{"v":9.41861574392727e-07,"d":"9.42E-07"},{"v":4.384055071154e-07,"d":"4.38E-07"},"AR/MAPK1/AKT1/ESR1/VDR/AKT2/HIF1A/GLI2",8]
["GO:0070372","regulation of ERK1 and ERK2 cascade","14/143","300/18670",{"v":7.84290082764658e-08,"d":"7.84E-08"},{"v":9.56266944286547e-07,"d":"9.56E-07"},{"v":4.4511073181634e-07,"d":"4.45E-07"},"BRAF/TLR4/FLT1/HMGCR/MAPK3/PTPN1/TNF/HRAS/FGF2/PRKCZ/PTPN22/CASR/ICAM1/IL1B",14]
["GO:0034440","lipid oxidation","9/143","101/18670",{"v":8.09037516414229e-08,"d":"8.09E-08"},{"v":9.8053409174994e-07,"d":"9.81E-07"},{"v":4.5640628880601e-07,"d":"4.56E-07"},"MAPK14/MTOR/AKT1/CNR1/PPARG/ALOX12/PPARA/AKT2/ACACB",9]
["GO:1903426","regulation of reactive oxygen species biosynthetic process","9/143","101/18670",{"v":8.09037516414229e-08,"d":"8.09E-08"},{"v":9.8053409174994e-07,"d":"9.81E-07"},{"v":4.5640628880601e-07,"d":"4.56E-07"},"TLR4/PTGS2/MTOR/INSR/STAT3/AKT1/TNF/ICAM1/IL1B",9]
["GO:0022409","positive regulation of cell-cell adhesion","13/143","255/18670",{"v":8.40412851445867e-08,"d":"8.40E-08"},{"v":1.01551976795608e-06,"d":"1.02E-06"},{"v":4.72690967506081e-07,"d":"4.73E-07"},"PIK3CA/YES1/AKT1/PIK3R1/IL2/SHH/TNF/DPP4/IL6/PRKCZ/GLI2/ICAM1/IL1B",13]
["GO:0035094","response to nicotine","7/143","49/18670",{"v":8.76026849994885e-08,"d":"8.76E-08"},{"v":1.05540377642241e-06,"d":"1.06E-06"},{"v":4.91255658361794e-07,"d":"4.91E-07"},"MAPK1/CNR1/CASP3/PPARA/TNF/HMOX1/KCNJ11",7]
["GO:0001667","ameboidal-type cell migration","17/143","461/18670",{"v":9.21930081799115e-08,"d":"9.22E-08"},{"v":1.10741037718778e-06,"d":"1.11E-06"},{"v":5.15463016217528e-07,"d":"5.15E-07"},"PTGS2/FGFR1/MMP9/PIK3CA/MTOR/AKT1/NOS3/PPARG/ALOX12/SHH/VEGFA/FGF2/SIRT1/DPP4/HMOX1/HIF1A/NFE2L2",17]
["GO:0005977","glycogen metabolic process","8/143","74/18670",{"v":9.57374119877526e-08,"d":"9.57E-08"},{"v":1.142709955062e-06,"d":"1.14E-06"},{"v":5.31893805793889e-07,"d":"5.32E-07"},"GSK3B/GCK/MTOR/INSR/AKT1/AKT2/GCGR/GYS1",8]
["GO:1900182","positive regulation of protein localization to nucleus","8/143","74/18670",{"v":9.57374119877526e-08,"d":"9.57E-08"},{"v":1.142709955062e-06,"d":"1.14E-06"},{"v":5.31893805793889e-07,"d":"5.32E-07"},"MAPK14/PTGS2/MAPK1/F2/AKT1/PIK3R1/SHH/EIF2AK3",8]
["GO:0044264","cellular polysaccharide metabolic process","9/143","103/18670",{"v":9.59786029449308e-08,"d":"9.60E-08"},{"v":1.142709955062e-06,"d":"1.14E-06"},{"v":5.31893805793889e-07,"d":"5.32E-07"},"GSK3B/GCK/MTOR/INSR/AKT1/MGAM/AKT2/GCGR/GYS1",9]
["GO:0090335","regulation of brown fat cell differentiation","5/143","16/18670",{"v":1.00293935621676e-07,"d":"1.00E-07"},{"v":1.19058607447667e-06,"d":"1.19E-06"},{"v":5.54178560774195e-07,"d":"5.54E-07"},"MAPK14/PTGS2/MTOR/SIRT1/FTO",5]
["GO:0032388","positive regulation of intracellular transport","12/143","215/18670",{"v":1.01213204496044e-07,"d":"1.01E-07"},{"v":1.19449286239063e-06,"d":"1.19E-06"},{"v":5.5599704173061e-07,"d":"5.56E-07"},"GSK3B/MAPK14/PTGS2/MAPK1/PIK3R1/CNR1/SHH/HRAS/AKT2/TP53/ATP2A1/IL1B",12]
["GO:0070374","positive regulation of ERK1 and ERK2 cascade","12/143","215/18670",{"v":1.01213204496044e-07,"d":"1.01E-07"},{"v":1.19449286239063e-06,"d":"1.19E-06"},{"v":5.5599704173061e-07,"d":"5.56E-07"},"BRAF/TLR4/FLT1/HMGCR/MAPK3/TNF/HRAS/FGF2/PRKCZ/PTPN22/CASR/ICAM1",12]
["GO:0071887","leukocyte apoptotic process","9/143","104/18670",{"v":1.04393593284794e-07,"d":"1.04E-07"},{"v":1.22844553958386e-06,"d":"1.23E-06"},{"v":5.71800893450986e-07,"d":"5.72E-07"},"AKT1/CASP3/IL2/SIRT1/IL6/HIF1A/TP53/CCR5/HCAR2",9]
["GO:0046165","alcohol biosynthetic process","11/143","175/18670",{"v":1.06081431591903e-07,"d":"1.06E-07"},{"v":1.24468879734499e-06,"d":"1.24E-06"},{"v":5.79361594353946e-07,"d":"5.79E-07"},"HMGCR/HRH1/VDR/AKR1B1/TNF/CFTR/FGF2/CYP3A4/PRKAA2/ACACB/IL1B",11]
["GO:0002699","positive regulation of immune effector process","12/143","216/18670",{"v":1.06471406301399e-07,"d":"1.06E-07"},{"v":1.24565390956087e-06,"d":"1.25E-06"},{"v":5.79810822268036e-07,"d":"5.80E-07"},"TLR4/MAPK14/TLR9/MAPK3/HK1/IL2/TNF/HMOX1/IL6/PRKCZ/RBP4/IL1B",12]
["GO:0036294","cellular response to decreased oxygen levels","12/143","217/18670",{"v":1.11972426066502e-07,"d":"1.12E-07"},{"v":1.30623740840691e-06,"d":"1.31E-06"},{"v":6.08010443376424e-07,"d":"6.08E-07"},"PTGS2/MTOR/NAMPT/AKT1/VEGFA/SIRT1/HMOX1/HIF1A/CASR/TP53/ICAM1/NFE2L2",12]
["GO:0002675","positive regulation of acute inflammatory response","6/143","31/18670",{"v":1.14271038304352e-07,"d":"1.14E-07"},{"v":1.32630610988642e-06,"d":"1.33E-06"},{"v":6.17351762194898e-07,"d":"6.17E-07"},"PTGS2/PIK3CG/CNR1/TNF/IL6/IL1B",6]
["GO:0042326","negative regulation of phosphorylation","17/143","468/18670",{"v":1.14348031707105e-07,"d":"1.14E-07"},{"v":1.32630610988642e-06,"d":"1.33E-06"},{"v":6.17351762194898e-07,"d":"6.17E-07"},"TLR4/IGF1R/HMGCR/MTOR/STAT3/AKT1/PTPN1/CASP3/PPARA/IL2/FABP4/SIRT1/IGFBP3/PRKCZ/FOXO1/PTPN22/IL1B",17]
["GO:0001558","regulation of cell growth","16/143","416/18670",{"v":1.27939621863868e-07,"d":"1.28E-07"},{"v":1.47971311229982e-06,"d":"1.48E-06"},{"v":6.88757663567889e-07,"d":"6.89E-07"},"GSK3B/F2/MTOR/AKT1/PPARG/AVPR1A/PPARA/IL2/SGK1/VEGFA/HNF4A/SIRT1/IGFBP3/AGTR1/PARP2/TP53",16]
["GO:0051341","regulation of oxidoreductase activity","9/143","107/18670",{"v":1.33614388897867e-07,"d":"1.34E-07"},{"v":1.53489800789448e-06,"d":"1.53E-06"},{"v":7.14444412869545e-07,"d":"7.14E-07"},"AKT1/NOS3/CNR1/VDR/TNF/AOC3/HIF1A/AGTR1/IL1B",9]
["GO:0062014","negative regulation of small molecule metabolic process","9/143","107/18670",{"v":1.33614388897867e-07,"d":"1.34E-07"},{"v":1.53489800789448e-06,"d":"1.53E-06"},{"v":7.14444412869545e-07,"d":"7.14E-07"},"GCK/CLK2/STAT3/AKT1/CNR1/PPARA/SIRT1/TP53/ACACB",9]
["GO:0060421","positive regulation of heart growth","7/143","52/18670",{"v":1.33848566399889e-07,"d":"1.34E-07"},{"v":1.53489800789448e-06,"d":"1.53E-06"},{"v":7.14444412869545e-07,"d":"7.14E-07"},"MAPK14/MAPK1/FGFR1/MTOR/FGF2/PARP2/ACACB",7]
["GO:0009416","response to light stimulus","14/143","314/18670",{"v":1.37492804184198e-07,"d":"1.37E-07"},{"v":1.56780527137362e-06,"d":"1.57E-06"},{"v":7.29761658976174e-07,"d":"7.30E-07"},"PTGS2/MAPK8/MAPK10/HMGCR/MTOR/HRH1/AKT1/PIK3R1/CASP3/AKT2/FOS/SIRT1/HIF1A/TP53",14]
["GO:0050863","regulation of T cell activation","14/143","314/18670",{"v":1.37492804184198e-07,"d":"1.37E-07"},{"v":1.56780527137362e-06,"d":"1.57E-06"},{"v":7.29761658976174e-07,"d":"7.30E-07"},"PIK3CA/YES1/AKT1/PIK3R1/CASP3/IL2/SHH/DPP4/IL6/PRKCZ/GLI2/PTPN22/CYP26B1/IL1B",14]
["GO:0031649","heat generation","5/143","17/18670",{"v":1.41208940496112e-07,"d":"1.41E-07"},{"v":1.60183608799399e-06,"d":"1.60E-06"},{"v":7.45601882023414e-07,"d":"7.46E-07"},"PTGS2/CNR1/TNF/ADRB2/IL1B",5]
["GO:1903706","regulation of hemopoiesis","17/143","475/18670",{"v":1.41268647088403e-07,"d":"1.41E-07"},{"v":1.60183608799399e-06,"d":"1.60E-06"},{"v":7.45601882023414e-07,"d":"7.46E-07"},"TLR4/MAPK14/TLR9/PRKCB/MTOR/STAT3/PIK3R1/IL2/SHH/TNF/FOS/ACE/PRKCZ/HIF1A/GLI2/CYP26B1/NFE2L2",17]
["GO:1900542","regulation of purine nucleotide metabolic process","10/143","142/18670",{"v":1.42237573459642e-07,"d":"1.42E-07"},{"v":1.608317590404e-06,"d":"1.61E-06"},{"v":7.48618807682327e-07,"d":"7.49E-07"},"NOS2/GCK/INSR/STAT3/NOS3/PPARA/HIF1A/OGT/TP53/PRKAA2",10]
["GO:0031016","pancreas development","8/143","78/18670",{"v":1.45155002798652e-07,"d":"1.45E-07"},{"v":1.63218736480262e-06,"d":"1.63E-06"},{"v":7.5972940061283e-07,"d":"7.60E-07"},"GSK3B/INSR/AKT1/SHH/HNF4A/IL6/FOXO1/EIF2AK3",8]
["GO:0055021","regulation of cardiac muscle tissue growth","8/143","78/18670",{"v":1.45155002798652e-07,"d":"1.45E-07"},{"v":1.63218736480262e-06,"d":"1.63E-06"},{"v":7.5972940061283e-07,"d":"7.60E-07"},"MAPK14/MAPK1/FGFR1/MTOR/PPARA/FGF2/PARP2/RBP4",8]
["GO:0043491","protein kinase B signaling","13/143","269/18670",{"v":1.562433024867e-07,"d":"1.56E-07"},{"v":1.7520024611251e-06,"d":"1.75E-06"},{"v":8.15499377317958e-07,"d":"8.15E-07"},"FGFR1/PIK3CA/PIK3CG/IGF1R/MTOR/INSR/AKT1/PIK3R1/ESR1/TNF/FGF2/SIRT1/IL1B",13]
["GO:0061138","morphogenesis of a branching epithelium","11/143","182/18670",{"v":1.58013448581542e-07,"d":"1.58E-07"},{"v":1.76354679651153e-06,"d":"1.76E-06"},{"v":8.20872884791877e-07,"d":"8.21E-07"},"AR/FGFR1/ESR1/VDR/SHH/TNF/VEGFA/FGF2/PGF/GLI2/CASR",11]
["GO:0030595","leukocyte chemotaxis","12/143","224/18670",{"v":1.5814414207848e-07,"d":"1.58E-07"},{"v":1.76354679651153e-06,"d":"1.76E-06"},{"v":8.20872884791877e-07,"d":"8.21E-07"},"MAPK14/FLT1/PIK3CG/MAPK3/HRH1/CYP19A1/VEGFA/SERPINE1/IL6/PGF/CCR5/IL1B",12]
["GO:0032386","regulation of intracellular transport","16/143","423/18670",{"v":1.60452915830841e-07,"d":"1.60E-07"},{"v":1.7748665162832e-06,"d":"1.77E-06"},{"v":8.26141841103318e-07,"d":"8.26E-07"},"GSK3B/MAPK14/PTGS2/MAPK1/PRKCB/MAPK3/PIK3R1/CNR1/PTPN1/SHH/HRAS/AKT2/HMOX1/TP53/ATP2A1/IL1B",16]
["GO:0006110","regulation of glycolytic process","8/143","79/18670",{"v":1.60474591146158e-07,"d":"1.60E-07"},{"v":1.7748665162832e-06,"d":"1.77E-06"},{"v":8.26141841103318e-07,"d":"8.26E-07"},"GCK/INSR/STAT3/PPARA/HIF1A/OGT/TP53/PRKAA2",8]
["GO:0030193","regulation of blood coagulation","8/143","79/18670",{"v":1.60474591146158e-07,"d":"1.60E-07"},{"v":1.7748665162832e-06,"d":"1.77E-06"},{"v":8.26141841103318e-07,"d":"8.26E-07"},"TLR4/SELP/F2/NOS3/ALOX12/PLAT/SERPINE1/NFE2L2",8]
["GO:0071322","cellular response to carbohydrate stimulus","10/143","144/18670",{"v":1.62224727458258e-07,"d":"1.62E-07"},{"v":1.78903206244255e-06,"d":"1.79E-06"},{"v":8.32735435763513e-07,"d":"8.33E-07"},"PIK3CA/IGF1R/PRKCB/HMGCR/CFTR/KCNJ11/HIF1A/CASR/ICAM1/PRKAA2",10]
["GO:0007548","sex differentiation","13/143","270/18670",{"v":1.63081232964748e-07,"d":"1.63E-07"},{"v":1.78903206244255e-06,"d":"1.79E-06"},{"v":8.32735435763513e-07,"d":"8.33E-07"},"AR/REN/INSR/CYP19A1/NOS3/ESR1/CASP3/SHH/VEGFA/HNF4A/SIRT1/RBP4/ICAM1",13]
["GO:0045927","positive regulation of growth","13/143","270/18670",{"v":1.63081232964748e-07,"d":"1.63E-07"},{"v":1.78903206244255e-06,"d":"1.79E-06"},{"v":8.32735435763513e-07,"d":"8.33E-07"},"MAPK14/MAPK1/FGFR1/F2/MTOR/INSR/AKT1/AVPR1A/IL2/VEGFA/FGF2/PARP2/ACACB",13]
["GO:0002720","positive regulation of cytokine production involved in immune response","7/143","54/18670",{"v":1.74938791797834e-07,"d":"1.75E-07"},{"v":1.91392494377739e-06,"d":"1.91E-06"},{"v":8.90868953963366e-07,"d":"8.91E-07"},"TLR4/MAPK14/MAPK3/HK1/IL6/PRKCZ/IL1B",7]
["GO:1900046","regulation of hemostasis","8/143","80/18670",{"v":1.7716152410116e-07,"d":"1.77E-07"},{"v":1.93301846242991e-06,"d":"1.93E-06"},{"v":8.99756357330337e-07,"d":"9.00E-07"},"TLR4/SELP/F2/NOS3/ALOX12/PLAT/SERPINE1/NFE2L2",8]
["GO:0016049","cell growth","17/143","484/18670",{"v":1.84357191674042e-07,"d":"1.84E-07"},{"v":2.00381531554931e-06,"d":"2.00E-06"},{"v":9.32709958090613e-07,"d":"9.33E-07"},"GSK3B/F2/MTOR/AKT1/PPARG/AVPR1A/PPARA/IL2/SGK1/VEGFA/HNF4A/SIRT1/IGFBP3/PRKCZ/AGTR1/PARP2/TP53",17]
["GO:0006140","regulation of nucleotide metabolic process","10/143","146/18670",{"v":1.84640097010843e-07,"d":"1.85E-07"},{"v":2.00381531554931e-06,"d":"2.00E-06"},{"v":9.32709958090613e-07,"d":"9.33E-07"},"NOS2/GCK/INSR/STAT3/NOS3/PPARA/HIF1A/OGT/TP53/PRKAA2",10]
["GO:0030811","regulation of nucleotide catabolic process","8/143","81/18670",{"v":1.95315773929662e-07,"d":"1.95E-07"},{"v":2.11400602370928e-06,"d":"2.11E-06"},{"v":9.84000099448622e-07,"d":"9.84E-07"},"GCK/INSR/STAT3/PPARA/HIF1A/OGT/TP53/PRKAA2",8]
["GO:0060419","heart growth","9/143","112/18670",{"v":1.98241126411401e-07,"d":"1.98E-07"},{"v":2.1399468792356e-06,"d":"2.14E-06"},{"v":9.96074712354827e-07,"d":"9.96E-07"},"MAPK14/MAPK1/FGFR1/MTOR/PPARA/FGF2/PARP2/RBP4/ACACB",9]
["GO:0010594","regulation of endothelial cell migration","12/143","229/18670",{"v":2.00842567378667e-07,"d":"2.01E-07"},{"v":2.15755327494169e-06,"d":"2.16E-06"},{"v":1.00426990902476e-06,"d":"1.00E-06"},"PTGS2/FGFR1/AKT1/NOS3/PPARG/ALOX12/VEGFA/FGF2/SIRT1/HMOX1/HIF1A/NFE2L2",12]
["GO:0016054","organic acid catabolic process","13/143","275/18670",{"v":2.01471130911057e-07,"d":"2.01E-07"},{"v":2.15755327494169e-06,"d":"2.16E-06"},{"v":1.00426990902476e-06,"d":"1.00E-06"},"NOS2/MTOR/AKT1/NOS3/CNR1/PPARA/PON1/FGF2/AKT2/LIPE/SORD/CYP26B1/ACACB",13]
["GO:0046395","carboxylic acid catabolic process","13/143","275/18670",{"v":2.01471130911057e-07,"d":"2.01E-07"},{"v":2.15755327494169e-06,"d":"2.16E-06"},{"v":1.00426990902476e-06,"d":"1.00E-06"},"NOS2/MTOR/AKT1/NOS3/CNR1/PPARA/PON1/FGF2/AKT2/LIPE/SORD/CYP26B1/ACACB",13]
["GO:0051092","positive regulation of NF-kappaB transcription factor activity","10/143","149/18670",{"v":2.23366665176087e-07,"d":"2.23E-07"},{"v":2.38572100430818e-06,"d":"2.39E-06"},{"v":1.1104744637278e-06,"d":"1.11E-06"},"AR/TLR4/TLR9/PRKCB/STAT3/IKBKB/TNF/PRKCZ/ICAM1/IL1B",10]
["GO:0060688","regulation of morphogenesis of a branching structure","7/143","56/18670",{"v":2.26182321144194e-07,"d":"2.26E-07"},{"v":2.40943693682025e-06,"d":"2.41E-06"},{"v":1.12151344833271e-06,"d":"1.12E-06"},"AR/FGFR1/ESR1/SHH/TNF/VEGFA/PGF",7]
["GO:0005976","polysaccharide metabolic process","9/143","114/18670",{"v":2.30852793199196e-07,"d":"2.31E-07"},{"v":2.45273518863608e-06,"d":"2.45E-06"},{"v":1.14166735689062e-06,"d":"1.14E-06"},"GSK3B/GCK/MTOR/INSR/AKT1/MGAM/AKT2/GCGR/GYS1",9]
["GO:0006970","response to osmotic stress","8/143","83/18670",{"v":2.36454794712634e-07,"d":"2.36E-07"},{"v":2.50567803402289e-06,"d":"2.51E-06"},{"v":1.16631050574708e-06,"d":"1.17E-06"},"PTGS2/MAPK10/CASP3/SLC2A1/AKR1B1/TNF/SORD/TP53",8]
["GO:0048754","branching morphogenesis of an epithelial tube","10/143","150/18670",{"v":2.3777279118042e-07,"d":"2.38E-07"},{"v":2.51306594960402e-06,"d":"2.51E-06"},{"v":1.16974933685022e-06,"d":"1.17E-06"},"AR/ESR1/VDR/SHH/TNF/VEGFA/FGF2/PGF/GLI2/CASR",10]
["GO:0009152","purine ribonucleotide biosynthetic process","13/143","280/18670",{"v":2.47781621282431e-07,"d":"2.48E-07"},{"v":2.61203125768563e-06,"d":"2.61E-06"},{"v":1.21581442460404e-06,"d":"1.22E-06"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2/ACACB",13]
["GO:0046660","female sex differentiation","9/143","115/18670",{"v":2.48838501334628e-07,"d":"2.49E-07"},{"v":2.61635909974695e-06,"d":"2.62E-06"},{"v":1.21782889238273e-06,"d":"1.22E-06"},"INSR/CYP19A1/NOS3/ESR1/CASP3/VEGFA/SIRT1/RBP4/ICAM1",9]
["GO:0010507","negative regulation of autophagy","8/143","84/18670",{"v":2.59668883955896e-07,"d":"2.60E-07"},{"v":2.71612310659811e-06,"d":"2.72E-06"},{"v":1.26426574807848e-06,"d":"1.26E-06"},"PIK3CA/MTOR/NAMPT/STAT3/AKT1/HMOX1/PTPN22/TP53",8]
["GO:0050818","regulation of coagulation","8/143","84/18670",{"v":2.59668883955896e-07,"d":"2.60E-07"},{"v":2.71612310659811e-06,"d":"2.72E-06"},{"v":1.26426574807848e-06,"d":"1.26E-06"},"TLR4/SELP/F2/NOS3/ALOX12/PLAT/SERPINE1/NFE2L2",8]
["GO:0030949","positive regulation of vascular endothelial growth factor receptor signaling pathway","5/143","19/18670",{"v":2.62094367156708e-07,"d":"2.62E-07"},{"v":2.73442783054215e-06,"d":"2.73E-06"},{"v":1.27278599351738e-06,"d":"1.27E-06"},"FLT1/PRKCB/VEGFA/HIF1A/IL1B",5]
["GO:0021782","glial cell development","9/143","116/18670",{"v":2.68029335303718e-07,"d":"2.68E-07"},{"v":2.78200704951141e-06,"d":"2.78E-06"},{"v":1.29493255112997e-06,"d":"1.29E-06"},"TLR4/BACE2/AKT1/HDAC11/SHH/TNF/AKT2/IL6/IL1B",9]
["GO:1900180","regulation of protein localization to nucleus","9/143","116/18670",{"v":2.68029335303718e-07,"d":"2.68E-07"},{"v":2.78200704951141e-06,"d":"2.78E-06"},{"v":1.29493255112997e-06,"d":"1.29E-06"},"GSK3B/MAPK14/PTGS2/MAPK1/F2/AKT1/PIK3R1/SHH/EIF2AK3",9]
["GO:0050731","positive regulation of peptidyl-tyrosine phosphorylation","11/143","192/18670",{"v":2.71064872459476e-07,"d":"2.71E-07"},{"v":2.80631867958046e-06,"d":"2.81E-06"},{"v":1.30624881330586e-06,"d":"1.31E-06"},"MTOR/STAT3/YES1/PTPN1/IL2/TNF/VEGFA/ACE/IL6/TP53/ICAM1",11]
["GO:0042133","neurotransmitter metabolic process","10/143","153/18670",{"v":2.86004316555464e-07,"d":"2.86E-07"},{"v":2.94591723515653e-06,"d":"2.95E-06"},{"v":1.37122733797852e-06,"d":"1.37E-06"},"TLR4/NOS2/PTGS2/MTOR/INSR/AKT1/NOS3/TNF/ICAM1/IL1B",10]
["GO:0090316","positive regulation of intracellular protein transport","10/143","153/18670",{"v":2.86004316555464e-07,"d":"2.86E-07"},{"v":2.94591723515653e-06,"d":"2.95E-06"},{"v":1.37122733797852e-06,"d":"1.37E-06"},"GSK3B/MAPK14/PTGS2/MAPK1/PIK3R1/SHH/HRAS/AKT2/TP53/IL1B",10]
["GO:0010508","positive regulation of autophagy","9/143","117/18670",{"v":2.88492846595299e-07,"d":"2.88E-07"},{"v":2.96400772339536e-06,"d":"2.96E-06"},{"v":1.37964786376058e-06,"d":"1.38E-06"},"GSK3B/MAPK3/HK2/SIRT1/HMOX1/FOXO1/HIF1A/ADRB2/PRKAA2",9]
["GO:0032722","positive regulation of chemokine production","7/143","58/18670",{"v":2.89521712591449e-07,"d":"2.90E-07"},{"v":2.96704782929161e-06,"d":"2.97E-06"},{"v":1.38106293281464e-06,"d":"1.38E-06"},"TLR4/TLR9/TNF/HMOX1/IL6/HIF1A/IL1B",7]
["GO:0030947","regulation of vascular endothelial growth factor receptor signaling pathway","6/143","36/18670",{"v":2.92928877799086e-07,"d":"2.93E-07"},{"v":2.99438408416843e-06,"d":"2.99E-06"},{"v":1.39378705810835e-06,"d":"1.39E-06"},"FLT1/PRKCB/PTPN1/VEGFA/HIF1A/IL1B",6]
["GO:0042446","hormone biosynthetic process","8/143","86/18670",{"v":3.1200710841907e-07,"d":"3.12E-07"},{"v":3.18137222891787e-06,"d":"3.18E-06"},{"v":1.48082387397623e-06,"d":"1.48E-06"},"HSD11B1/CYP19A1/VDR/AKR1B1/TNF/CYP3A4/HIF1A/IL1B",8]
["GO:0002440","production of molecular mediator of immune response","13/143","286/18670",{"v":3.15804586920924e-07,"d":"3.16E-07"},{"v":3.21200243179875e-06,"d":"3.21E-06"},{"v":1.49508122345531e-06,"d":"1.50E-06"},"TLR4/MAPK14/TLR9/MAPK3/HK1/IL2/TNF/SIRT1/HMOX1/IL6/PRKCZ/RBP4/IL1B",13]
["GO:1902652","secondary alcohol metabolic process","10/143","155/18670",{"v":3.22742400167294e-07,"d":"3.23E-07"},{"v":3.2743389370356e-06,"d":"3.27E-06"},{"v":1.52409681123719e-06,"d":"1.52E-06"},"FGFR1/HMGCR/PON1/CFTR/CYP3A4/LIPE/NR0B2/PRKAA2/ACACB/CETP",10]
["GO:0097755","positive regulation of blood vessel diameter","7/143","59/18670",{"v":3.26407380000306e-07,"d":"3.26E-07"},{"v":3.3032426856031e-06,"d":"3.30E-06"},{"v":1.53755055315934e-06,"d":"1.54E-06"},"ADRB3/MTNR1B/NOS3/ALOX12/HMOX1/ADRB2/CASR",7]
["GO:0001763","morphogenesis of a branching structure","11/143","196/18670",{"v":3.33357774841269e-07,"d":"3.33E-07"},{"v":3.35846425942337e-06,"d":"3.36E-06"},{"v":1.56325437496563e-06,"d":"1.56E-06"},"AR/FGFR1/ESR1/VDR/SHH/TNF/VEGFA/FGF2/PGF/GLI2/CASR",11]
["GO:0051193","regulation of cofactor metabolic process","9/143","119/18670",{"v":3.3352337754155e-07,"d":"3.34E-07"},{"v":3.35846425942337e-06,"d":"3.36E-06"},{"v":1.56325437496563e-06,"d":"1.56E-06"},"GCK/INSR/STAT3/PPARA/HIF1A/OGT/TP53/PRKAA2/NFE2L2",9]
["GO:0032885","regulation of polysaccharide biosynthetic process","6/143","37/18670",{"v":3.47430841649555e-07,"d":"3.47E-07"},{"v":3.48118823514208e-06,"d":"3.48E-06"},{"v":1.62037833911596e-06,"d":"1.62E-06"},"GSK3B/GCK/MTOR/INSR/AKT1/AKT2",6]
["GO:0045923","positive regulation of fatty acid metabolic process","6/143","37/18670",{"v":3.47430841649555e-07,"d":"3.47E-07"},{"v":3.48118823514208e-06,"d":"3.48E-06"},{"v":1.62037833911596e-06,"d":"1.62E-06"},"PTGS2/PPARG/AVPR1A/PPARA/AKT2/IL1B",6]
["GO:0043271","negative regulation of ion transport","10/143","157/18670",{"v":3.63556373398244e-07,"d":"3.64E-07"},{"v":3.63376839386689e-06,"d":"3.63E-06"},{"v":1.69139937201522e-06,"d":"1.69E-06"},"PTGS2/MMP9/TLR9/MTOR/MTNR1B/AKT1/NOS3/CNR1/AKT2/ICAM1",10]
["GO:0046890","regulation of lipid biosynthetic process","11/143","198/18670",{"v":3.69009359198659e-07,"d":"3.69E-07"},{"v":3.67918691141914e-06,"d":"3.68E-06"},{"v":1.71254019436246e-06,"d":"1.71E-06"},"PTGS2/HMGCR/MTOR/AKT1/VDR/AVPR1A/TNF/SIRT1/PRKAA2/ACACB/IL1B",11]
["GO:0043470","regulation of carbohydrate catabolic process","8/143","88/18670",{"v":3.73131850706244e-07,"d":"3.73E-07"},{"v":3.71114921783507e-06,"d":"3.71E-06"},{"v":1.72741759411399e-06,"d":"1.73E-06"},"GCK/INSR/STAT3/PPARA/HIF1A/OGT/TP53/PRKAA2",8]
["GO:0051896","regulation of protein kinase B signaling","12/143","244/18670",{"v":3.97231469299668e-07,"d":"3.97E-07"},{"v":3.94115928363984e-06,"d":"3.94E-06"},{"v":1.83447969568216e-06,"d":"1.83E-06"},"FGFR1/PIK3CA/PIK3CG/IGF1R/MTOR/INSR/AKT1/PIK3R1/ESR1/TNF/FGF2/SIRT1",12]
["GO:0006094","gluconeogenesis","8/143","89/18670",{"v":4.07355867686813e-07,"d":"4.07E-07"},{"v":4.0317275119712e-06,"d":"4.03E-06"},{"v":1.87663621968703e-06,"d":"1.88E-06"},"GCK/CLK2/PPARA/SIRT1/GAPDH/FOXO1/OGT/RBP4",8]
["GO:0046326","positive regulation of glucose import","6/143","38/18670",{"v":4.09985395339575e-07,"d":"4.10E-07"},{"v":4.03800700811338e-06,"d":"4.04E-06"},{"v":1.87955911808897e-06,"d":"1.88E-06"},"MAPK14/INSR/AKT1/PIK3R1/AKT2/NFE2L2",6]
["GO:0048009","insulin-like growth factor receptor signaling pathway","6/143","38/18670",{"v":4.09985395339575e-07,"d":"4.10E-07"},{"v":4.03800700811338e-06,"d":"4.04E-06"},{"v":1.87955911808897e-06,"d":"1.88E-06"},"AR/IGF1R/AKT1/PIK3R1/IGFBP3/EIF2AK3",6]
["GO:0090303","positive regulation of wound healing","7/143","61/18670",{"v":4.12128134736459e-07,"d":"4.12E-07"},{"v":4.03945445378496e-06,"d":"4.04E-06"},{"v":1.88023285632283e-06,"d":"1.88E-06"},"TLR4/SELP/F2/MTOR/HRAS/SERPINE1/NFE2L2",7]
["GO:1905953","negative regulation of lipid localization","7/143","61/18670",{"v":4.12128134736459e-07,"d":"4.12E-07"},{"v":4.03945445378496e-06,"d":"4.04E-06"},{"v":1.88023285632283e-06,"d":"1.88E-06"},"AKT1/PPARG/PPARA/SHH/TNF/AKT2/IL6",7]
["GO:0009260","ribonucleotide biosynthetic process","13/143","293/18670",{"v":4.15962010846249e-07,"d":"4.16E-07"},{"v":4.05738366242317e-06,"d":"4.06E-06"},{"v":1.88857831176864e-06,"d":"1.89E-06"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2/ACACB",13]
["GO:0072001","renal system development","13/143","293/18670",{"v":4.15962010846249e-07,"d":"4.16E-07"},{"v":4.05738366242317e-06,"d":"4.06E-06"},{"v":1.88857831176864e-06,"d":"1.89E-06"},"FGFR1/MMP9/REN/AKR1B1/SHH/VEGFA/FGF2/ACE/PGF/GLI2/AGTR1/CYP26B1/RBP4",13]
["GO:0001503","ossification","15/143","398/18670",{"v":4.19591378242418e-07,"d":"4.20E-07"},{"v":4.08294687289738e-06,"d":"4.08E-06"},{"v":1.90047714335508e-06,"d":"1.90E-06"},"MAPK14/PTGS2/MAPK1/MAPK3/AKT1/MMP2/SHH/TNF/IGFBP3/IL6/HIF1A/EIF2AK3/GLI2/ADRB2/CASR",15]
["GO:0016236","macroautophagy","13/143","295/18670",{"v":4.49376616023155e-07,"d":"4.49E-07"},{"v":4.36229386489624e-06,"d":"4.36E-06"},{"v":2.03050395729256e-06,"d":"2.03E-06"},"MAPK8/PIK3CA/MTOR/MAPK3/AKT1/CASP3/SIRT1/GAPDH/HMOX1/HIF1A/ADRB2/TP53/PRKAA2",13]
["GO:0050870","positive regulation of T cell activation","11/143","202/18670",{"v":4.50569010658617e-07,"d":"4.51E-07"},{"v":4.36340515585187e-06,"d":"4.36E-06"},{"v":2.03102122659009e-06,"d":"2.03E-06"},"PIK3CA/YES1/AKT1/PIK3R1/IL2/SHH/DPP4/IL6/PRKCZ/GLI2/IL1B",11]
["GO:0050890","cognition","13/143","296/18670",{"v":4.66968040497086e-07,"d":"4.67E-07"},{"v":4.51142393301242e-06,"d":"4.51E-06"},{"v":2.09991908677247e-06,"d":"2.10E-06"},"PTGS2/MAPK1/HMGCR/MTOR/INSR/HRH1/CNR1/CASP3/TNF/SGK1/FOS/PRKCZ/HIF1A",13]
["GO:0045785","positive regulation of cell adhesion","15/143","403/18670",{"v":4.91459692004443e-07,"d":"4.91E-07"},{"v":4.73673531722377e-06,"d":"4.74E-06"},{"v":2.20479410698735e-06,"d":"2.20E-06"},"GSK3B/PIK3CA/YES1/AKT1/PIK3R1/IL2/SHH/TNF/VEGFA/DPP4/IL6/PRKCZ/GLI2/ICAM1/IL1B",15]
["GO:0045833","negative regulation of lipid metabolic process","8/143","92/18670",{"v":5.26617357323639e-07,"d":"5.27E-07"},{"v":5.06353221483632e-06,"d":"5.06E-06"},{"v":2.35690728743421e-06,"d":"2.36E-06"},"PIK3CG/AKT1/CNR1/TNF/SIRT1/ACACB/HCAR2/IL1B",8]
["GO:0046390","ribose phosphate biosynthetic process","13/143","300/18670",{"v":5.43659090433162e-07,"d":"5.44E-07"},{"v":5.21500473477118e-06,"d":"5.22E-06"},{"v":2.42741275099865e-06,"d":"2.43E-06"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2/ACACB",13]
["GO:0001990","regulation of systemic arterial blood pressure by hormone","6/143","40/18670",{"v":5.62903147804668e-07,"d":"5.63E-07"},{"v":5.38683674305743e-06,"d":"5.39E-06"},{"v":2.50739488508238e-06,"d":"2.51E-06"},"REN/NOS3/AVPR2/AVPR1A/ACE/AGTR1",6]
["GO:0002064","epithelial cell development","11/143","207/18670",{"v":5.74650083837719e-07,"d":"5.75E-07"},{"v":5.47069313790674e-06,"d":"5.47E-06"},{"v":2.54642727190895e-06,"d":"2.55E-06"},"AR/GSK3B/FGFR1/IKBKB/ESR1/TNF/VEGFA/HNF4A/HIF1A/ICAM1/IL1B",11]
["GO:0071456","cellular response to hypoxia","11/143","207/18670",{"v":5.74650083837719e-07,"d":"5.75E-07"},{"v":5.47069313790674e-06,"d":"5.47E-06"},{"v":2.54642727190895e-06,"d":"2.55E-06"},"PTGS2/MTOR/AKT1/VEGFA/SIRT1/HMOX1/HIF1A/CASR/TP53/ICAM1/NFE2L2",11]
["GO:0032768","regulation of monooxygenase activity","7/143","64/18670",{"v":5.7572017706232e-07,"d":"5.76E-07"},{"v":5.47069313790674e-06,"d":"5.47E-06"},{"v":2.54642727190895e-06,"d":"2.55E-06"},"AKT1/NOS3/CNR1/VDR/TNF/HIF1A/IL1B",7]
["GO:0031281","positive regulation of cyclase activity","5/143","22/18670",{"v":5.82684382621688e-07,"d":"5.83E-07"},{"v":5.51099621694531e-06,"d":"5.51E-06"},{"v":2.56518702629814e-06,"d":"2.57E-06"},"NOS2/MAPK14/MAPK8/MAPK3/NOS3",5]
["GO:0042359","vitamin D metabolic process","5/143","22/18670",{"v":5.82684382621688e-07,"d":"5.83E-07"},{"v":5.51099621694531e-06,"d":"5.51E-06"},{"v":2.56518702629814e-06,"d":"2.57E-06"},"FGFR1/VDR/TNF/CYP3A4/IL1B",5]
["GO:1901215","negative regulation of neuron death","11/143","208/18670",{"v":6.0280345521163e-07,"d":"6.03E-07"},{"v":5.68799157738153e-06,"d":"5.69E-06"},{"v":2.64757253055777e-06,"d":"2.65E-06"},"GSK3B/PIK3CA/MTNR1B/STAT3/AKT1/PPARA/HRAS/SIRT1/HMOX1/HIF1A/PARP2",11]
["GO:0016125","sterol metabolic process","10/143","166/18670",{"v":6.08571700436169e-07,"d":"6.09E-07"},{"v":5.72906568224561e-06,"d":"5.73E-06"},{"v":2.66669117204588e-06,"d":"2.67E-06"},"HMGCR/CYP19A1/PON1/CFTR/LIPE/CYP26B1/NR0B2/PRKAA2/ACACB/CETP",10]
["GO:0002687","positive regulation of leukocyte migration","9/143","128/18670",{"v":6.20153191548837e-07,"d":"6.20E-07"},{"v":5.81106509117985e-06,"d":"5.81E-06"},{"v":2.70485919315892e-06,"d":"2.70E-06"},"MAPK14/SELP/MAPK3/TNF/VEGFA/SERPINE1/IL6/PGF/ICAM1",9]
["GO:0034763","negative regulation of transmembrane transport","9/143","128/18670",{"v":6.20153191548837e-07,"d":"6.20E-07"},{"v":5.81106509117985e-06,"d":"5.81E-06"},{"v":2.70485919315892e-06,"d":"2.70E-06"},"MMP9/TLR9/PRKCB/MTOR/MTNR1B/AKT1/TNF/AKT2/IL1B",9]
["GO:0032729","positive regulation of interferon-gamma production","7/143","65/18670",{"v":6.41103292628476e-07,"d":"6.41E-07"},{"v":5.99350145163989e-06,"d":"5.99E-06"},{"v":2.78977730352491e-06,"d":"2.79E-06"},"TLR4/TLR9/IL2/TNF/HRAS/PTPN22/IL1B",7]
["GO:0007611","learning or memory","12/143","256/18670",{"v":6.62204143358672e-07,"d":"6.62E-07"},{"v":6.15357385866322e-06,"d":"6.15E-06"},{"v":2.86428573096712e-06,"d":"2.86E-06"},"PTGS2/MAPK1/HMGCR/MTOR/INSR/HRH1/CNR1/CASP3/SGK1/FOS/PRKCZ/HIF1A",12]
["GO:0050730","regulation of peptidyl-tyrosine phosphorylation","12/143","256/18670",{"v":6.62204143358672e-07,"d":"6.62E-07"},{"v":6.15357385866322e-06,"d":"6.15E-06"},{"v":2.86428573096712e-06,"d":"2.86E-06"},"MTOR/STAT3/YES1/PTPN1/IL2/TNF/VEGFA/ACE/IL6/PRKCZ/TP53/ICAM1",12]
["GO:0097529","myeloid leukocyte migration","11/143","210/18670",{"v":6.62786117188035e-07,"d":"6.63E-07"},{"v":6.15357385866322e-06,"d":"6.15E-06"},{"v":2.86428573096712e-06,"d":"2.86E-06"},"MAPK14/FLT1/PIK3CG/MAPK3/HRH1/CYP19A1/VEGFA/SERPINE1/IL6/PGF/IL1B",11]
["GO:0001660","fever generation","4/143","10/18670",{"v":6.68638309258089e-07,"d":"6.69E-07"},{"v":6.19370223312756e-06,"d":"6.19E-06"},{"v":2.88296416613749e-06,"d":"2.88E-06"},"PTGS2/CNR1/TNF/IL1B",4]
["GO:0051196","regulation of coenzyme metabolic process","8/143","95/18670",{"v":6.74550846319624e-07,"d":"6.75E-07"},{"v":6.23420508196766e-06,"d":"6.23E-06"},{"v":2.90181690678233e-06,"d":"2.90E-06"},"GCK/INSR/STAT3/PPARA/HIF1A/OGT/TP53/PRKAA2",8]
["GO:0046626","regulation of insulin receptor signaling pathway","7/143","66/18670",{"v":7.1260899274594e-07,"d":"7.13E-07"},{"v":6.57093668026325e-06,"d":"6.57E-06"},{"v":3.05855436282276e-06,"d":"3.06E-06"},"PRKCB/PIK3R1/PTPN1/SIRT1/PRKCZ/OGT/IL1B",7]
["GO:0008585","female gonad development","8/143","96/18670",{"v":7.31157156536323e-07,"d":"7.31E-07"},{"v":6.7113926749638e-06,"d":"6.71E-06"},{"v":3.12393199713574e-06,"d":"3.12E-06"},"INSR/CYP19A1/NOS3/ESR1/CASP3/VEGFA/SIRT1/ICAM1",8]
["GO:2001169","regulation of ATP biosynthetic process","8/143","96/18670",{"v":7.31157156536323e-07,"d":"7.31E-07"},{"v":6.7113926749638e-06,"d":"6.71E-06"},{"v":3.12393199713574e-06,"d":"3.12E-06"},"GCK/INSR/STAT3/PPARA/HIF1A/OGT/TP53/PRKAA2",8]
["GO:0042108","positive regulation of cytokine biosynthetic process","7/143","67/18670",{"v":7.90690265415591e-07,"d":"7.91E-07"},{"v":7.24143482896451e-06,"d":"7.24E-06"},{"v":3.37064914287666e-06,"d":"3.37E-06"},"TLR4/TLR9/STAT3/TNF/HMOX1/IL6/IL1B",7]
["GO:0072329","monocarboxylic acid catabolic process","9/143","132/18670",{"v":8.04289110394543e-07,"d":"8.04E-07"},{"v":7.34935060694608e-06,"d":"7.35E-06"},{"v":3.42088037924731e-06,"d":"3.42E-06"},"MTOR/AKT1/CNR1/PPARA/AKT2/LIPE/SORD/CYP26B1/ACACB",9]
["GO:0030324","lung development","10/143","172/18670",{"v":8.43084962361067e-07,"d":"8.43E-07"},{"v":7.68650434152612e-06,"d":"7.69E-06"},{"v":3.57781432580918e-06,"d":"3.58E-06"},"MAPK1/FGFR1/MAPK3/HSD11B1/NOS3/SHH/TNF/VEGFA/GLI2/RBP4",10]
["GO:0034612","response to tumor necrosis factor","13/143","312/18670",{"v":8.45823570692148e-07,"d":"8.46E-07"},{"v":7.69414340261082e-06,"d":"7.69E-06"},{"v":3.58137005686326e-06,"d":"3.58E-06"},"MAPK14/PTGS2/MAPK1/MAPK3/AKT1/IKBKB/CASP3/TNF/FABP4/SIRT1/KCNJ11/ICAM1/NFE2L2",13]
["GO:0060191","regulation of lipase activity","8/143","98/18670",{"v":8.56626191075008e-07,"d":"8.57E-07"},{"v":7.76188019006878e-06,"d":"7.76E-06"},{"v":3.61289929795691e-06,"d":"3.61E-06"},"FLT1/FGFR1/ESR1/AVPR1A/HRAS/FGF2/PRKCZ/AGTR1",8]
["GO:0071333","cellular response to glucose stimulus","9/143","133/18670",{"v":8.57104853004136e-07,"d":"8.57E-07"},{"v":7.76188019006878e-06,"d":"7.76E-06"},{"v":3.61289929795691e-06,"d":"3.61E-06"},"PIK3CA/IGF1R/HMGCR/CFTR/KCNJ11/HIF1A/CASR/ICAM1/PRKAA2",9]
["GO:0006775","fat-soluble vitamin metabolic process","6/143","43/18670",{"v":8.77334520967399e-07,"d":"8.77E-07"},{"v":7.89211142416896e-06,"d":"7.89E-06"},{"v":3.67351764334888e-06,"d":"3.67E-06"},"FGFR1/VDR/TNF/CYP3A4/CYP26B1/IL1B",6]
["GO:0010863","positive regulation of phospholipase C activity","6/143","43/18670",{"v":8.77334520967399e-07,"d":"8.77E-07"},{"v":7.89211142416896e-06,"d":"7.89E-06"},{"v":3.67351764334888e-06,"d":"3.67E-06"},"FLT1/FGFR1/ESR1/AVPR1A/HRAS/FGF2",6]
["GO:1904646","cellular response to amyloid-beta","6/143","43/18670",{"v":8.77334520967399e-07,"d":"8.77E-07"},{"v":7.89211142416896e-06,"d":"7.89E-06"},{"v":3.67351764334888e-06,"d":"3.67E-06"},"GSK3B/TLR4/IGF1R/NAMPT/ADRB2/ICAM1",6]
["GO:0015711","organic anion transport","16/143","482/18670",{"v":9.15463012135636e-07,"d":"9.15E-07"},{"v":8.20618409864456e-06,"d":"8.21E-06"},{"v":3.8197081174781e-06,"d":"3.82E-06"},"NOS2/AKT1/PPARG/SLC2A1/AVPR1A/PPARA/SLC22A12/CFTR/FABP4/AKT2/ACE/CASR/PRKAA2/ACACB/CETP/IL1B",16]
["GO:0044242","cellular lipid catabolic process","11/143","217/18670",{"v":9.16303165164857e-07,"d":"9.16E-07"},{"v":8.20618409864456e-06,"d":"8.21E-06"},{"v":3.8197081174781e-06,"d":"3.82E-06"},"PIK3CG/MTOR/AKT1/CNR1/PPARA/FABP4/FABP2/AKT2/LIPE/CYP26B1/ACACB",11]
["GO:0015909","long-chain fatty acid transport","7/143","69/18670",{"v":9.6851527797273e-07,"d":"9.69E-07"},{"v":8.64579473328726e-06,"d":"8.65E-06"},{"v":4.02433237273356e-06,"d":"4.02E-06"},"AKT1/PPARG/FABP4/AKT2/ACE/PRKAA2/ACACB",7]
["GO:0050921","positive regulation of chemotaxis","9/143","135/18670",{"v":9.71797579952002e-07,"d":"9.72E-07"},{"v":8.64579473328726e-06,"d":"8.65E-06"},{"v":4.02433237273356e-06,"d":"4.02E-06"},"MAPK14/FGFR1/MAPK3/VEGFA/FGF2/SERPINE1/IL6/PGF/CASR",9]
["GO:0071331","cellular response to hexose stimulus","9/143","135/18670",{"v":9.71797579952002e-07,"d":"9.72E-07"},{"v":8.64579473328726e-06,"d":"8.65E-06"},{"v":4.02433237273356e-06,"d":"4.02E-06"},"PIK3CA/IGF1R/HMGCR/CFTR/KCNJ11/HIF1A/CASR/ICAM1/PRKAA2",9]
["GO:0051249","regulation of lymphocyte activation","16/143","485/18670",{"v":9.93049809216455e-07,"d":"9.93E-07"},{"v":8.81549479760572e-06,"d":"8.82E-06"},{"v":4.10332215719634e-06,"d":"4.10E-06"},"TLR4/PIK3CA/TLR9/YES1/AKT1/PIK3R1/CASP3/IL2/SHH/DPP4/IL6/PRKCZ/GLI2/PTPN22/CYP26B1/IL1B",16]
["GO:0022600","digestive system process","8/143","100/18670",{"v":1.0000302041378e-06,"d":"1.00E-06"},{"v":8.83869490469393e-06,"d":"8.84E-06"},{"v":4.11412104207461e-06,"d":"4.11E-06"},"TLR4/TLR9/KCNQ1/VDR/FABP2/SGK1/SLC5A1/RBP4",8]
["GO:0055024","regulation of cardiac muscle tissue development","8/143","100/18670",{"v":1.0000302041378e-06,"d":"1.00E-06"},{"v":8.83869490469393e-06,"d":"8.84E-06"},{"v":4.11412104207461e-06,"d":"4.11E-06"},"MAPK14/MAPK1/FGFR1/MTOR/PPARA/FGF2/PARP2/RBP4",8]
["GO:0071326","cellular response to monosaccharide stimulus","9/143","136/18670",{"v":1.03395834286156e-06,"d":"1.03E-06"},{"v":9.11206183169272e-06,"d":"9.11E-06"},{"v":4.24136433293373e-06,"d":"4.24E-06"},"PIK3CA/IGF1R/HMGCR/CFTR/KCNJ11/HIF1A/CASR/ICAM1/PRKAA2",9]
["GO:0030323","respiratory tube development","10/143","176/18670",{"v":1.04020854495388e-06,"d":"1.04E-06"},{"v":9.11206183169272e-06,"d":"9.11E-06"},{"v":4.24136433293373e-06,"d":"4.24E-06"},"MAPK1/FGFR1/MAPK3/HSD11B1/NOS3/SHH/TNF/VEGFA/GLI2/RBP4",10]
["GO:0051897","positive regulation of protein kinase B signaling","10/143","176/18670",{"v":1.04020854495388e-06,"d":"1.04E-06"},{"v":9.11206183169272e-06,"d":"9.11E-06"},{"v":4.24136433293373e-06,"d":"4.24E-06"},"FGFR1/PIK3CA/PIK3CG/IGF1R/MTOR/INSR/PIK3R1/ESR1/TNF/FGF2",10]
["GO:0005984","disaccharide metabolic process","4/143","11/18670",{"v":1.04446558545094e-06,"d":"1.04E-06"},{"v":9.11206183169272e-06,"d":"9.11E-06"},{"v":4.24136433293373e-06,"d":"4.24E-06"},"BRAF/SLC2A1/MGAM/TREH",4]
["GO:0031652","positive regulation of heat generation","4/143","11/18670",{"v":1.04446558545094e-06,"d":"1.04E-06"},{"v":9.11206183169272e-06,"d":"9.11E-06"},{"v":4.24136433293373e-06,"d":"4.24E-06"},"PTGS2/CNR1/TNF/IL1B",4]
["GO:0060736","prostate gland growth","4/143","11/18670",{"v":1.04446558545094e-06,"d":"1.04E-06"},{"v":9.11206183169272e-06,"d":"9.11E-06"},{"v":4.24136433293373e-06,"d":"4.24E-06"},"AR/CYP19A1/ESR1/SHH",4]
["GO:0001933","negative regulation of protein phosphorylation","15/143","429/18670",{"v":1.07727289171107e-06,"d":"1.08E-06"},{"v":9.37376809747049e-06,"d":"9.37E-06"},{"v":4.36317997047851e-06,"d":"4.36E-06"},"TLR4/IGF1R/HMGCR/MTOR/AKT1/PTPN1/CASP3/IL2/FABP4/SIRT1/IGFBP3/PRKCZ/FOXO1/PTPN22/IL1B",15]
["GO:0046545","development of primary female sexual characteristics","8/143","101/18670",{"v":1.07909484521276e-06,"d":"1.08E-06"},{"v":9.37376809747049e-06,"d":"9.37E-06"},{"v":4.36317997047851e-06,"d":"4.36E-06"},"INSR/CYP19A1/NOS3/ESR1/CASP3/VEGFA/SIRT1/ICAM1",8]
["GO:0031018","endocrine pancreas development","6/143","45/18670",{"v":1.15749272793731e-06,"d":"1.16E-06"},{"v":1.00118174416458e-05,"d":"1.00E-05"},{"v":4.66017090195183e-06,"d":"4.66E-06"},"GSK3B/AKT1/HNF4A/IL6/FOXO1/EIF2AK3",6]
["GO:1900274","regulation of phospholipase C activity","6/143","45/18670",{"v":1.15749272793731e-06,"d":"1.16E-06"},{"v":1.00118174416458e-05,"d":"1.00E-05"},{"v":4.66017090195183e-06,"d":"4.66E-06"},"FLT1/FGFR1/ESR1/AVPR1A/HRAS/FGF2",6]
["GO:0045165","cell fate commitment","12/143","270/18670",{"v":1.16109375604786e-06,"d":"1.16E-06"},{"v":1.00215512249077e-05,"d":"1.00E-05"},{"v":4.66470165711068e-06,"d":"4.66E-06"},"AR/FGFR1/MTOR/STAT3/PPARG/CASP3/SHH/FGF2/IL6/GLI2/CYP26B1/TP53",12]
["GO:0033692","cellular polysaccharide biosynthetic process","7/143","71/18670",{"v":1.17870912610113e-06,"d":"1.18E-06"},{"v":1.01519458350157e-05,"d":"1.02E-05"},{"v":4.72539604864732e-06,"d":"4.73E-06"},"GSK3B/GCK/MTOR/INSR/AKT1/AKT2/GYS1",7]
["GO:0060562","epithelial tube morphogenesis","13/143","322/18670",{"v":1.20384353835294e-06,"d":"1.20E-06"},{"v":1.03464090090291e-05,"d":"1.03E-05"},{"v":4.81591224416531e-06,"d":"4.82E-06"},"AR/ESR1/VDR/CASP3/ALOX12/SHH/TNF/VEGFA/FGF2/HIF1A/PGF/GLI2/CASR",13]
["GO:0048771","tissue remodeling","10/143","179/18670",{"v":1.21338775412683e-06,"d":"1.21E-06"},{"v":1.04063424336979e-05,"d":"1.04E-05"},{"v":4.84380927717891e-06,"d":"4.84E-06"},"NOS3/VDR/MMP2/IL2/ACE/IL6/HIF1A/ADRB2/TP53/MC4R",10]
["GO:0050715","positive regulation of cytokine secretion","9/143","139/18670",{"v":1.24151237869347e-06,"d":"1.24E-06"},{"v":1.06250361711441e-05,"d":"1.06E-05"},{"v":4.94560400102661e-06,"d":"4.95E-06"},"TLR4/MAPK14/MAPK3/HK1/TNF/GAPDH/PRKCZ/PTPN22/IL1B",9]
["GO:0006816","calcium ion transport","15/143","434/18670",{"v":1.24432398584263e-06,"d":"1.24E-06"},{"v":1.06266318453396e-05,"d":"1.06E-05"},{"v":4.94634673475084e-06,"d":"4.95E-06"},"PTGS2/TLR9/PIK3CG/PRKCB/MCHR1/F2/GCK/NOS3/VDR/FGF2/TRPM6/CASR/ICAM1/CCR5/ATP2A1",15]
["GO:0032024","positive regulation of insulin secretion","7/143","72/18670",{"v":1.29735312324819e-06,"d":"1.30E-06"},{"v":1.10098227314648e-05,"d":"1.10E-05"},{"v":5.12470945738556e-06,"d":"5.12E-06"},"GCK/BLK/CFTR/HIF1A/CASR/NR0B2/RBP4",7]
["GO:0038034","signal transduction in absence of ligand","7/143","72/18670",{"v":1.29735312324819e-06,"d":"1.30E-06"},{"v":1.10098227314648e-05,"d":"1.10E-05"},{"v":5.12470945738556e-06,"d":"5.12E-06"},"GSK3B/FGFR1/AKT1/CASP3/IL2/TNF/IL1B",7]
["GO:0097192","extrinsic apoptotic signaling pathway in absence of ligand","7/143","72/18670",{"v":1.29735312324819e-06,"d":"1.30E-06"},{"v":1.10098227314648e-05,"d":"1.10E-05"},{"v":5.12470945738556e-06,"d":"5.12E-06"},"GSK3B/FGFR1/AKT1/CASP3/IL2/TNF/IL1B",7]
["GO:0033157","regulation of intracellular protein transport","11/143","225/18670",{"v":1.30748136877676e-06,"d":"1.31E-06"},{"v":1.10725618845363e-05,"d":"1.11E-05"},{"v":5.15391246445806e-06,"d":"5.15E-06"},"GSK3B/MAPK14/PTGS2/MAPK1/PIK3R1/PTPN1/SHH/HRAS/AKT2/TP53/IL1B",11]
["GO:0030810","positive regulation of nucleotide biosynthetic process","6/143","46/18670",{"v":1.32277057306777e-06,"d":"1.32E-06"},{"v":1.11321731388323e-05,"d":"1.11E-05"},{"v":5.18165953778601e-06,"d":"5.18E-06"},"NOS2/INSR/STAT3/NOS3/HIF1A/PRKAA2",6]
["GO:0045776","negative regulation of blood pressure","6/143","46/18670",{"v":1.32277057306777e-06,"d":"1.32E-06"},{"v":1.11321731388323e-05,"d":"1.11E-05"},{"v":5.18165953778601e-06,"d":"5.18E-06"},"NOS2/ADRB3/NOS3/CNR1/PPARA/ADRB2",6]
["GO:1900373","positive regulation of purine nucleotide biosynthetic process","6/143","46/18670",{"v":1.32277057306777e-06,"d":"1.32E-06"},{"v":1.11321731388323e-05,"d":"1.11E-05"},{"v":5.18165953778601e-06,"d":"5.18E-06"},"NOS2/INSR/STAT3/NOS3/HIF1A/PRKAA2",6]
["GO:0046822","regulation of nucleocytoplasmic transport","8/143","104/18670",{"v":1.34906416444327e-06,"d":"1.35E-06"},{"v":1.13064425210483e-05,"d":"1.13E-05"},{"v":5.26277618906712e-06,"d":"5.26E-06"},"GSK3B/MAPK14/PTGS2/MAPK1/PIK3R1/SHH/TP53/IL1B",8]
["GO:2001237","negative regulation of extrinsic apoptotic signaling pathway","8/143","104/18670",{"v":1.34906416444327e-06,"d":"1.35E-06"},{"v":1.13064425210483e-05,"d":"1.13E-05"},{"v":5.26277618906712e-06,"d":"5.26E-06"},"AR/AKT1/NOS3/TNF/SERPINE1/HMOX1/ICAM1/IL1B",8]
["GO:0032943","mononuclear cell proliferation","12/143","274/18670",{"v":1.35454082042733e-06,"d":"1.35E-06"},{"v":1.13288868617558e-05,"d":"1.13E-05"},{"v":5.27322328961487e-06,"d":"5.27E-06"},"TLR4/TLR9/PIK3CG/CASP3/IL2/SHH/IMPDH2/ACE/IL6/PTPN22/TP53/IL1B",12]
["GO:0002360","T cell lineage commitment","5/143","26/18670",{"v":1.42004040157036e-06,"d":"1.42E-06"},{"v":1.18035391079195e-05,"d":"1.18E-05"},{"v":5.49415825961513e-06,"d":"5.49E-06"},"MTOR/STAT3/SHH/IL6/TP53",5]
["GO:0030194","positive regulation of blood coagulation","5/143","26/18670",{"v":1.42004040157036e-06,"d":"1.42E-06"},{"v":1.18035391079195e-05,"d":"1.18E-05"},{"v":5.49415825961513e-06,"d":"5.49E-06"},"TLR4/SELP/F2/SERPINE1/NFE2L2",5]
["GO:1900048","positive regulation of hemostasis","5/143","26/18670",{"v":1.42004040157036e-06,"d":"1.42E-06"},{"v":1.18035391079195e-05,"d":"1.18E-05"},{"v":5.49415825961513e-06,"d":"5.49E-06"},"TLR4/SELP/F2/SERPINE1/NFE2L2",5]
["GO:0055017","cardiac muscle tissue growth","8/143","105/18670",{"v":1.45097097912623e-06,"d":"1.45E-06"},{"v":1.20359232038995e-05,"d":"1.20E-05"},{"v":5.60232539395156e-06,"d":"5.60E-06"},"MAPK14/MAPK1/FGFR1/MTOR/PPARA/FGF2/PARP2/RBP4",8]
["GO:0061614","pri-miRNA transcription by RNA polymerase II","6/143","47/18670",{"v":1.50684018434125e-06,"d":"1.51E-06"},{"v":1.24738017713975e-05,"d":"1.25E-05"},{"v":5.80614342906216e-06,"d":"5.81E-06"},"STAT3/PPARG/PPARA/FOS/HIF1A/TP53",6]
["GO:0031392","regulation of prostaglandin biosynthetic process","4/143","12/18670",{"v":1.55737847404363e-06,"d":"1.56E-06"},{"v":1.28205720895048e-05,"d":"1.28E-05"},{"v":5.96755357817079e-06,"d":"5.97E-06"},"PTGS2/AVPR1A/SIRT1/IL1B",4]
["GO:0042368","vitamin D biosynthetic process","4/143","12/18670",{"v":1.55737847404363e-06,"d":"1.56E-06"},{"v":1.28205720895048e-05,"d":"1.28E-05"},{"v":5.96755357817079e-06,"d":"5.97E-06"},"VDR/TNF/CYP3A4/IL1B",4]
["GO:0048639","positive regulation of developmental growth","10/143","184/18670",{"v":1.55823158795365e-06,"d":"1.56E-06"},{"v":1.28205720895048e-05,"d":"1.28E-05"},{"v":5.96755357817079e-06,"d":"5.97E-06"},"MAPK14/MAPK1/FGFR1/MTOR/INSR/AKT1/VEGFA/FGF2/PARP2/ACACB",10]
["GO:1900076","regulation of cellular response to insulin stimulus","7/143","74/18670",{"v":1.56480204102329e-06,"d":"1.56E-06"},{"v":1.28225074130815e-05,"d":"1.28E-05"},{"v":5.96845440748281e-06,"d":"5.97E-06"},"PRKCB/PIK3R1/PTPN1/SIRT1/PRKCZ/OGT/IL1B",7]
["GO:1903036","positive regulation of response to wounding","7/143","74/18670",{"v":1.56480204102329e-06,"d":"1.56E-06"},{"v":1.28225074130815e-05,"d":"1.28E-05"},{"v":5.96845440748281e-06,"d":"5.97E-06"},"TLR4/SELP/F2/MTOR/HRAS/SERPINE1/NFE2L2",7]
["GO:0001822","kidney development","12/143","278/18670",{"v":1.57601226343911e-06,"d":"1.58E-06"},{"v":1.28882780654576e-05,"d":"1.29E-05"},{"v":5.99906847752475e-06,"d":"6.00E-06"},"FGFR1/MMP9/REN/AKR1B1/SHH/VEGFA/FGF2/ACE/PGF/GLI2/AGTR1/CYP26B1",12]
["GO:0046328","regulation of JNK cascade","10/143","185/18670",{"v":1.63661977548581e-06,"d":"1.64E-06"},{"v":1.33569291354165e-05,"d":"1.34E-05"},{"v":6.21721009787691e-06,"d":"6.22E-06"},"TLR4/TLR9/IGF1R/AKT1/PTPN1/TNF/HRAS/MAP3K9/PTPN22/IL1B",10]
["GO:0006111","regulation of gluconeogenesis","6/143","48/18670",{"v":1.71130753423635e-06,"d":"1.71E-06"},{"v":1.38825108188151e-05,"d":"1.39E-05"},{"v":6.46185104162656e-06,"d":"6.46E-06"},"GCK/CLK2/PPARA/SIRT1/FOXO1/OGT",6]
["GO:0045912","negative regulation of carbohydrate metabolic process","6/143","48/18670",{"v":1.71130753423635e-06,"d":"1.71E-06"},{"v":1.38825108188151e-05,"d":"1.39E-05"},{"v":6.46185104162656e-06,"d":"6.46E-06"},"GSK3B/GCK/CLK2/STAT3/PPARA/TP53",6]
["GO:0055023","positive regulation of cardiac muscle tissue growth","6/143","48/18670",{"v":1.71130753423635e-06,"d":"1.71E-06"},{"v":1.38825108188151e-05,"d":"1.39E-05"},{"v":6.46185104162656e-06,"d":"6.46E-06"},"MAPK14/MAPK1/FGFR1/MTOR/FGF2/PARP2",6]
["GO:0150076","neuroinflammatory response","7/143","75/18670",{"v":1.71492329683097e-06,"d":"1.71E-06"},{"v":1.38840190111435e-05,"d":"1.39E-05"},{"v":6.46255305542618e-06,"d":"6.46E-06"},"BACE2/PTGS2/MMP9/NAMPT/TNF/IL6/IL1B",7]
["GO:0050820","positive regulation of coagulation","5/143","27/18670",{"v":1.73206933146824e-06,"d":"1.73E-06"},{"v":1.39948436203262e-05,"d":"1.40E-05"},{"v":6.5141382568088e-06,"d":"6.51E-06"},"TLR4/SELP/F2/SERPINE1/NFE2L2",5]
["GO:1905475","regulation of protein localization to membrane","10/143","187/18670",{"v":1.80376840733491e-06,"d":"1.80E-06"},{"v":1.45451285117365e-05,"d":"1.45E-05"},{"v":6.77027772935518e-06,"d":"6.77E-06"},"AR/MAPK8/AKT1/PIK3R1/TNF/HRAS/AKT2/KCNJ11/PRKCZ/TP53",10]
["GO:0051251","positive regulation of lymphocyte activation","13/143","334/18670",{"v":1.80749412693788e-06,"d":"1.81E-06"},{"v":1.4546195280009e-05,"d":"1.45E-05"},{"v":6.77077427481178e-06,"d":"6.77E-06"},"TLR4/PIK3CA/TLR9/YES1/AKT1/PIK3R1/IL2/SHH/DPP4/IL6/PRKCZ/GLI2/IL1B",13]
["GO:0019674","NAD metabolic process","7/143","76/18670",{"v":1.87690514450823e-06,"d":"1.88E-06"},{"v":1.50449743068699e-05,"d":"1.50E-05"},{"v":7.00293946570032e-06,"d":"7.00E-06"},"PTGS2/GCK/NAMPT/HK2/HK1/GAPDH/TP53",7]
["GO:0061045","negative regulation of wound healing","7/143","76/18670",{"v":1.87690514450823e-06,"d":"1.88E-06"},{"v":1.50449743068699e-05,"d":"1.50E-05"},{"v":7.00293946570032e-06,"d":"7.00E-06"},"F2/HMGCR/NOS3/ALOX12/PLAT/FGF2/SERPINE1",7]
["GO:0009755","hormone-mediated signaling pathway","11/143","235/18670",{"v":1.99797636866346e-06,"d":"2.00E-06"},{"v":1.59838109493077e-05,"d":"1.60E-05"},{"v":7.43993696673102e-06,"d":"7.44E-06"},"AR/REN/ESR1/VDR/PPARG/PPARA/GCGR/HNF4A/SIRT1/RXRG/NR0B2",11]
["GO:0051348","negative regulation of transferase activity","12/143","285/18670",{"v":2.04159050183842e-06,"d":"2.04E-06"},{"v":1.6300509568919e-05,"d":"1.63E-05"},{"v":7.58734973173627e-06,"d":"7.59E-06"},"GSK3B/IGF1R/HMGCR/AKT1/PTPN1/PPARG/CASP3/FABP4/SIRT1/PTPN22/TP53/IL1B",12]
["GO:0010959","regulation of metal ion transport","14/143","394/18670",{"v":2.08079714944801e-06,"d":"2.08E-06"},{"v":1.6548264952781e-05,"d":"1.65E-05"},{"v":7.70267169374819e-06,"d":"7.70E-06"},"PTGS2/TLR9/PIK3CG/MCHR1/F2/GCK/MTNR1B/KCNQ1/AKT1/NOS3/ADRB2/CASR/ICAM1/ATP2A1",14]
["GO:0050867","positive regulation of cell activation","14/143","394/18670",{"v":2.08079714944801e-06,"d":"2.08E-06"},{"v":1.6548264952781e-05,"d":"1.65E-05"},{"v":7.70267169374819e-06,"d":"7.70E-06"},"TLR4/PIK3CA/TLR9/SELP/YES1/AKT1/PIK3R1/IL2/SHH/DPP4/IL6/PRKCZ/GLI2/IL1B",14]
["GO:1904019","epithelial cell apoptotic process","8/143","111/18670",{"v":2.21079322246438e-06,"d":"2.21E-06"},{"v":1.75428896675632e-05,"d":"1.75E-05"},{"v":8.16563670296916e-06,"d":"8.17E-06"},"PIK3CG/MTOR/TNF/SERPINE1/HMOX1/IL6/ICAM1/NFE2L2",8]
["GO:0014074","response to purine-containing compound","9/143","149/18670",{"v":2.21452979746166e-06,"d":"2.21E-06"},{"v":1.75428896675632e-05,"d":"1.75E-05"},{"v":8.16563670296916e-06,"d":"8.17E-06"},"PTGS2/PIK3CG/REN/KCNQ1/PPARG/CFTR/FOS/KCNJ11/IL1B",9]
["GO:0031650","regulation of heat generation","4/143","13/18670",{"v":2.23616746777986e-06,"d":"2.24E-06"},{"v":1.76023770040375e-05,"d":"1.76E-05"},{"v":8.19332609663695e-06,"d":"8.19E-06"},"PTGS2/CNR1/TNF/IL1B",4]
["GO:1901550","regulation of endothelial cell development","4/143","13/18670",{"v":2.23616746777986e-06,"d":"2.24E-06"},{"v":1.76023770040375e-05,"d":"1.76E-05"},{"v":8.19332609663695e-06,"d":"8.19E-06"},"IKBKB/TNF/VEGFA/IL1B",4]
["GO:1903140","regulation of establishment of endothelial barrier","4/143","13/18670",{"v":2.23616746777986e-06,"d":"2.24E-06"},{"v":1.76023770040375e-05,"d":"1.76E-05"},{"v":8.19332609663695e-06,"d":"8.19E-06"},"IKBKB/TNF/VEGFA/IL1B",4]
["GO:0000271","polysaccharide biosynthetic process","7/143","78/18670",{"v":2.23943284512828e-06,"d":"2.24E-06"},{"v":1.76023770040375e-05,"d":"1.76E-05"},{"v":8.19332609663695e-06,"d":"8.19E-06"},"GSK3B/GCK/MTOR/INSR/AKT1/AKT2/GYS1",7]
["GO:0006874","cellular calcium ion homeostasis","15/143","458/18670",{"v":2.41742306860578e-06,"d":"2.42E-06"},{"v":1.89645902746438e-05,"d":"1.90E-05"},{"v":8.8273914581892e-06,"d":"8.83E-06"},"PIK3CG/PRKCB/MCHR1/F2/MTNR1B/CNR1/ESR1/VDR/AVPR1A/IL2/FGF2/AGTR1/CASR/CCR5/ATP2A1",15]
["GO:0071260","cellular response to mechanical stimulus","7/143","79/18670",{"v":2.44155378648765e-06,"d":"2.44E-06"},{"v":1.91168466686693e-05,"d":"1.91E-05"},{"v":8.89826178929634e-06,"d":"8.90E-06"},"TLR4/PTGS2/MAPK8/MAPK3/AKT1/SLC2A1/IL1B",7]
["GO:0050663","cytokine secretion","11/143","240/18670",{"v":2.45035262297309e-06,"d":"2.45E-06"},{"v":1.9148701578755e-05,"d":"1.91E-05"},{"v":8.9130891995973e-06,"d":"8.91E-06"},"TLR4/NOS2/MAPK14/TLR9/MAPK3/HK1/TNF/GAPDH/PRKCZ/PTPN22/IL1B",11]
["GO:0050999","regulation of nitric-oxide synthase activity","6/143","51/18670",{"v":2.4645576186046e-06,"d":"2.46E-06"},{"v":1.92225996919295e-05,"d":"1.92E-05"},{"v":8.94748633465619e-06,"d":"8.95E-06"},"AKT1/NOS3/CNR1/TNF/HIF1A/IL1B",6]
["GO:0010575","positive regulation of vascular endothelial growth factor production","5/143","29/18670",{"v":2.51669336844172e-06,"d":"2.52E-06"},{"v":1.9591489914331e-05,"d":"1.96E-05"},{"v":9.11919256985969e-06,"d":"9.12E-06"},"PTGS2/IL6/HIF1A/EIF2AK3/IL1B",5]
["GO:0032609","interferon-gamma production","8/143","113/18670",{"v":2.52953614713509e-06,"d":"2.53E-06"},{"v":1.96536704867617e-05,"d":"1.97E-05"},{"v":9.14813557606185e-06,"d":"9.15E-06"},"TLR4/TLR9/AVPR2/IL2/TNF/HRAS/PTPN22/IL1B",8]
["GO:0014855","striated muscle cell proliferation","7/143","81/18670",{"v":2.89170892110265e-06,"d":"2.89E-06"},{"v":2.24245933192021e-05,"d":"2.24E-05"},{"v":1.04379087896224e-05,"d":"1.04E-05"},"MAPK14/MAPK1/FGFR1/STAT3/SHH/FGF2/RBP4",7]
["GO:1990845","adaptive thermogenesis","9/143","154/18670",{"v":2.90936401084592e-06,"d":"2.91E-06"},{"v":2.25183661871975e-05,"d":"2.25E-05"},{"v":1.04815569677251e-05,"d":"1.05E-05"},"TLR4/IGF1R/ADRB3/LNPEP/FABP4/VEGFA/OGT/ADRB2/MC4R",9]
["GO:0051346","negative regulation of hydrolase activity","15/143","466/18670",{"v":2.98734298916264e-06,"d":"2.99E-06"},{"v":2.30777946949053e-05,"d":"2.31E-05"},{"v":1.07419524921678e-05,"d":"1.07E-05"},"GSK3B/PTGS2/MMP9/TLR9/AKT1/NOS3/IKBKB/TNF/HRAS/VEGFA/SERPINE1/SIRT1/GAPDH/PRKCZ/TP53",15]
["GO:0060541","respiratory system development","10/143","198/18670",{"v":3.01598180495306e-06,"d":"3.02E-06"},{"v":2.3254655898e-05,"d":"2.33E-05"},{"v":1.08242755506085e-05,"d":"1.08E-05"},"MAPK1/FGFR1/MAPK3/HSD11B1/NOS3/SHH/TNF/VEGFA/GLI2/RBP4",10]
["GO:2001236","regulation of extrinsic apoptotic signaling pathway","9/143","155/18670",{"v":3.06881328821652e-06,"d":"3.07E-06"},{"v":2.3617026978518e-05,"d":"2.36E-05"},{"v":1.09929473402193e-05,"d":"1.10E-05"},"AR/FGFR1/AKT1/NOS3/TNF/SERPINE1/HMOX1/ICAM1/IL1B",9]
["GO:0007569","cell aging","8/143","116/18670",{"v":3.08047369459265e-06,"d":"3.08E-06"},{"v":2.36617789671936e-05,"d":"2.37E-05"},{"v":1.10137779153517e-05,"d":"1.10E-05"},"MAPK14/MTOR/NAMPT/HRAS/SERPINE1/SIRT1/TP53/ICAM1",8]
["GO:0048872","homeostasis of number of cells","11/143","246/18670",{"v":3.10989962090268e-06,"d":"3.11E-06"},{"v":2.38137093475569e-05,"d":"2.38E-05"},{"v":1.10844964978487e-05,"d":"1.11E-05"},"MAPK14/STAT3/AKT1/NOS3/CASP3/IL2/VEGFA/HMOX1/IL6/HIF1A/HCAR2",11]
["GO:2001279","regulation of unsaturated fatty acid biosynthetic process","4/143","14/18670",{"v":3.11201883519209e-06,"d":"3.11E-06"},{"v":2.38137093475569e-05,"d":"2.38E-05"},{"v":1.10844964978487e-05,"d":"1.11E-05"},"PTGS2/AVPR1A/SIRT1/IL1B",4]
["GO:0032637","interleukin-8 production","7/143","82/18670",{"v":3.14153107342463e-06,"d":"3.14E-06"},{"v":2.39489977122842e-05,"d":"2.39E-05"},{"v":1.11474687708001e-05,"d":"1.11E-05"},"TLR4/NOS2/TLR9/TNF/SERPINE1/PTPN22/IL1B",7]
["GO:0032642","regulation of chemokine production","7/143","82/18670",{"v":3.14153107342463e-06,"d":"3.14E-06"},{"v":2.39489977122842e-05,"d":"2.39E-05"},{"v":1.11474687708001e-05,"d":"1.11E-05"},"TLR4/TLR9/TNF/HMOX1/IL6/HIF1A/IL1B",7]
["GO:0070661","leukocyte proliferation","12/143","298/18670",{"v":3.23720075520947e-06,"d":"3.24E-06"},{"v":2.46319335659548e-05,"d":"2.46E-05"},{"v":1.14653528924119e-05,"d":"1.15E-05"},"TLR4/TLR9/PIK3CG/CASP3/IL2/SHH/IMPDH2/ACE/IL6/PTPN22/TP53/IL1B",12]
["GO:0055074","calcium ion homeostasis","15/143","471/18670",{"v":3.40198151097413e-06,"d":"3.40E-06"},{"v":2.58371879107379e-05,"d":"2.58E-05"},{"v":1.20263590493605e-05,"d":"1.20E-05"},"PIK3CG/PRKCB/MCHR1/F2/MTNR1B/CNR1/ESR1/VDR/AVPR1A/IL2/FGF2/AGTR1/CASR/CCR5/ATP2A1",15]
["GO:0001505","regulation of neurotransmitter levels","13/143","354/18670",{"v":3.42532162073042e-06,"d":"3.43E-06"},{"v":2.59657339339265e-05,"d":"2.60E-05"},{"v":1.20861929846392e-05,"d":"1.21E-05"},"GSK3B/TLR4/NOS2/PTGS2/PRKCB/MTOR/INSR/AKT1/NOS3/CNR1/TNF/ICAM1/IL1B",13]
["GO:0051353","positive regulation of oxidoreductase activity","6/143","54/18670",{"v":3.46837168102851e-06,"d":"3.47E-06"},{"v":2.62429318968288e-05,"d":"2.62E-05"},{"v":1.22152194963916e-05,"d":"1.22E-05"},"AKT1/VDR/TNF/HIF1A/AGTR1/IL1B",6]
["GO:0010543","regulation of platelet activation","5/143","31/18670",{"v":3.55671819141664e-06,"d":"3.56E-06"},{"v":2.68611851471167e-05,"d":"2.69E-05"},{"v":1.2502995998892e-05,"d":"1.25E-05"},"TLR4/SELP/F2/NOS3/ALOX12",5]
["GO:0071383","cellular response to steroid hormone stimulus","11/143","250/18670",{"v":3.63164462300649e-06,"d":"3.63E-06"},{"v":2.73759728751029e-05,"d":"2.74E-05"},{"v":1.27426127123035e-05,"d":"1.27E-05"},"AR/ESR1/VDR/PPARG/PPARA/HNF4A/SIRT1/FOXO1/RXRG/NR0B2/ICAM1",11]
["GO:0030099","myeloid cell differentiation","14/143","416/18670",{"v":3.90636624191273e-06,"d":"3.91E-06"},{"v":2.93921385636853e-05,"d":"2.94E-05"},{"v":1.36810713618153e-05,"d":"1.37E-05"},"TLR4/MAPK14/MMP9/PRKCB/MTOR/STAT3/PIK3R1/PPARG/CASP3/TNF/VEGFA/FOS/SIRT1/HIF1A",14]
["GO:0002573","myeloid leukocyte differentiation","10/143","204/18670",{"v":3.93707724513005e-06,"d":"3.94E-06"},{"v":2.95682535960788e-05,"d":"2.96E-05"},{"v":1.37630471023978e-05,"d":"1.38E-05"},"TLR4/MAPK14/MMP9/MTOR/PIK3R1/PPARG/TNF/VEGFA/FOS/SIRT1",10]
["GO:0030730","sequestering of triglyceride","4/143","15/18670",{"v":4.21843332911658e-06,"d":"4.22E-06"},{"v":3.15059374838818e-05,"d":"3.15E-05"},{"v":1.46649750614074e-05,"d":"1.47E-05"},"PPARG/PPARA/TNF/IL1B",4]
["GO:0042362","fat-soluble vitamin biosynthetic process","4/143","15/18670",{"v":4.21843332911658e-06,"d":"4.22E-06"},{"v":3.15059374838818e-05,"d":"3.15E-05"},{"v":1.46649750614074e-05,"d":"1.47E-05"},"VDR/TNF/CYP3A4/IL1B",4]
["GO:0045073","regulation of chemokine biosynthetic process","4/143","15/18670",{"v":4.21843332911658e-06,"d":"4.22E-06"},{"v":3.15059374838818e-05,"d":"3.15E-05"},{"v":1.46649750614074e-05,"d":"1.47E-05"},"TNF/HMOX1/IL6/IL1B",4]
["GO:0009435","NAD biosynthetic process","6/143","56/18670",{"v":4.30578123724374e-06,"d":"4.31E-06"},{"v":3.20990836986421e-05,"d":"3.21E-05"},{"v":1.49410650667176e-05,"d":"1.49E-05"},"PTGS2/GCK/NAMPT/HK2/HK1/GAPDH",6]
["GO:1903578","regulation of ATP metabolic process","8/143","122/18670",{"v":4.49238876235036e-06,"d":"4.49E-06"},{"v":3.33673205687968e-05,"d":"3.34E-05"},{"v":1.55313875125198e-05,"d":"1.55E-05"},"GCK/INSR/STAT3/PPARA/HIF1A/OGT/TP53/PRKAA2",8]
["GO:1905477","positive regulation of protein localization to membrane","8/143","122/18670",{"v":4.49238876235036e-06,"d":"4.49E-06"},{"v":3.33673205687968e-05,"d":"3.34E-05"},{"v":1.55313875125198e-05,"d":"1.55E-05"},"MAPK8/AKT1/PIK3R1/TNF/HRAS/AKT2/KCNJ11/TP53",8]
["GO:0045862","positive regulation of proteolysis","13/143","363/18670",{"v":4.50203306652337e-06,"d":"4.50E-06"},{"v":3.33777103540048e-05,"d":"3.34E-05"},{"v":1.55362236149544e-05,"d":"1.55E-05"},"GSK3B/MAPK14/MAPK3/STAT3/AKT1/PPARG/ALOX12/TNF/SIRT1/EIF2AK3/OGT/NFE2L2/IL1B",13]
["GO:0070838","divalent metal ion transport","15/143","483/18670",{"v":4.61470409148075e-06,"d":"4.61E-06"},{"v":3.41504975545047e-05,"d":"3.42E-05"},{"v":1.58959305758694e-05,"d":"1.59E-05"},"PTGS2/TLR9/PIK3CG/PRKCB/MCHR1/F2/GCK/NOS3/VDR/FGF2/TRPM6/CASR/ICAM1/CCR5/ATP2A1",15]
["GO:0045981","positive regulation of nucleotide metabolic process","6/143","57/18670",{"v":4.78220157344084e-06,"d":"4.78E-06"},{"v":3.52611146981576e-05,"d":"3.53E-05"},{"v":1.64128862361405e-05,"d":"1.64E-05"},"NOS2/INSR/STAT3/NOS3/HIF1A/PRKAA2",6]
["GO:1900544","positive regulation of purine nucleotide metabolic process","6/143","57/18670",{"v":4.78220157344084e-06,"d":"4.78E-06"},{"v":3.52611146981576e-05,"d":"3.53E-05"},{"v":1.64128862361405e-05,"d":"1.64E-05"},"NOS2/INSR/STAT3/NOS3/HIF1A/PRKAA2",6]
["GO:0071229","cellular response to acid chemical","10/143","209/18670",{"v":4.88220328953201e-06,"d":"4.88E-06"},{"v":3.59330162109556e-05,"d":"3.59E-05"},{"v":1.67256342359087e-05,"d":"1.67E-05"},"MTOR/YES1/AKT1/PPARG/MMP2/AVPR1A/TNF/VEGFA/CYP26B1/PRKAA2",10]
["GO:0016242","negative regulation of macroautophagy","5/143","33/18670",{"v":4.9073001560319e-06,"d":"4.91E-06"},{"v":3.60521797307026e-05,"d":"3.61E-05"},{"v":1.67811009252022e-05,"d":"1.68E-05"},"PIK3CA/MTOR/AKT1/HMOX1/TP53",5]
["GO:0050829","defense response to Gram-negative bacterium","7/143","88/18670",{"v":5.04923981786055e-06,"d":"5.05E-06"},{"v":3.69608006920425e-05,"d":"3.70E-05"},{"v":1.72040340229759e-05,"d":"1.72E-05"},"TLR4/NOS2/TLR9/SELP/F2/SERPINE1/IL6",7]
["GO:1904035","regulation of epithelial cell apoptotic process","7/143","88/18670",{"v":5.04923981786055e-06,"d":"5.05E-06"},{"v":3.69608006920425e-05,"d":"3.70E-05"},{"v":1.72040340229759e-05,"d":"1.72E-05"},"MTOR/TNF/SERPINE1/HMOX1/IL6/ICAM1/NFE2L2",7]
["GO:0009612","response to mechanical stimulus","10/143","210/18670",{"v":5.09317414814918e-06,"d":"5.09E-06"},{"v":3.71480521652394e-05,"d":"3.71E-05"},{"v":1.72911934095534e-05,"d":"1.73E-05"},"TLR4/MAPK14/PTGS2/MAPK8/MAPK3/AKT1/PPARG/SLC2A1/FOS/IL1B",10]
["GO:0050707","regulation of cytokine secretion","10/143","210/18670",{"v":5.09317414814918e-06,"d":"5.09E-06"},{"v":3.71480521652394e-05,"d":"3.71E-05"},{"v":1.72911934095534e-05,"d":"1.73E-05"},"TLR4/MAPK14/TLR9/MAPK3/HK1/TNF/GAPDH/PRKCZ/PTPN22/IL1B",10]
["GO:2001242","regulation of intrinsic apoptotic signaling pathway","9/143","165/18670",{"v":5.12412644397017e-06,"d":"5.12E-06"},{"v":3.73065896496246e-05,"d":"3.73E-05"},{"v":1.73649873811182e-05,"d":"1.74E-05"},"PTGS2/MMP9/AKT1/PTPN1/SIRT1/HIF1A/EIF2AK3/TP53/NFE2L2",9]
["GO:0072511","divalent inorganic cation transport","15/143","489/18670",{"v":5.35527132728104e-06,"d":"5.36E-06"},{"v":3.89194584072418e-05,"d":"3.89E-05"},{"v":1.81157246070737e-05,"d":"1.81E-05"},"PTGS2/TLR9/PIK3CG/PRKCB/MCHR1/F2/GCK/NOS3/VDR/FGF2/TRPM6/CASR/ICAM1/CCR5/ATP2A1",15]
["GO:0032602","chemokine production","7/143","89/18670",{"v":5.445498203851e-06,"d":"5.45E-06"},{"v":3.95042593713062e-05,"d":"3.95E-05"},{"v":1.83879301733509e-05,"d":"1.84E-05"},"TLR4/TLR9/TNF/HMOX1/IL6/HIF1A/IL1B",7]
["GO:0002739","regulation of cytokine secretion involved in immune response","4/143","16/18670",{"v":5.59114646028155e-06,"d":"5.59E-06"},{"v":4.02721723687183e-05,"d":"4.03E-05"},{"v":1.87453683534444e-05,"d":"1.87E-05"},"MAPK14/MAPK3/HK1/TNF",4]
["GO:0042033","chemokine biosynthetic process","4/143","16/18670",{"v":5.59114646028155e-06,"d":"5.59E-06"},{"v":4.02721723687183e-05,"d":"4.03E-05"},{"v":1.87453683534444e-05,"d":"1.87E-05"},"TNF/HMOX1/IL6/IL1B",4]
["GO:0050755","chemokine metabolic process","4/143","16/18670",{"v":5.59114646028155e-06,"d":"5.59E-06"},{"v":4.02721723687183e-05,"d":"4.03E-05"},{"v":1.87453683534444e-05,"d":"1.87E-05"},"TNF/HMOX1/IL6/IL1B",4]
["GO:1902001","fatty acid transmembrane transport","4/143","16/18670",{"v":5.59114646028155e-06,"d":"5.59E-06"},{"v":4.02721723687183e-05,"d":"4.03E-05"},{"v":1.87453683534444e-05,"d":"1.87E-05"},"AKT1/AKT2/PRKAA2/ACACB",4]
["GO:0015850","organic hydroxy compound transport","11/143","262/18670",{"v":5.6844990528194196e-06,"d":"5.68E-06"},{"v":4.07993832727181e-05,"d":"4.08E-05"},{"v":1.8990767645664e-05,"d":"1.90E-05"},"REN/CYP19A1/CNR1/PPARG/PON1/SHH/CFTR/SIRT1/AGTR1/RBP4/CETP",11]
["GO:0034504","protein localization to nucleus","11/143","262/18670",{"v":5.6844990528194196e-06,"d":"5.68E-06"},{"v":4.07993832727181e-05,"d":"4.08E-05"},{"v":1.8990767645664e-05,"d":"1.90E-05"},"GSK3B/MAPK14/PTGS2/MAPK1/F2/STAT3/AKT1/PIK3R1/SHH/EIF2AK3/TP53",11]
["GO:0010574","regulation of vascular endothelial growth factor production","5/143","34/18670",{"v":5.71807202925958e-06,"d":"5.72E-06"},{"v":4.08953278700402e-05,"d":"4.09E-05"},{"v":1.90354266921604e-05,"d":"1.90E-05"},"PTGS2/IL6/HIF1A/EIF2AK3/IL1B",5]
["GO:0097009","energy homeostasis","5/143","34/18670",{"v":5.71807202925958e-06,"d":"5.72E-06"},{"v":4.08953278700402e-05,"d":"4.09E-05"},{"v":1.90354266921604e-05,"d":"1.90E-05"},"PIK3CA/STAT3/FOXO1/PRKAA2/ACACB",5]
["GO:1903035","negative regulation of response to wounding","7/143","90/18670",{"v":5.86729177568456e-06,"d":"5.87E-06"},{"v":4.18885310546227e-05,"d":"4.19E-05"},{"v":1.94977300259452e-05,"d":"1.95E-05"},"F2/HMGCR/NOS3/ALOX12/PLAT/FGF2/SERPINE1",7]
["GO:0072503","cellular divalent inorganic cation homeostasis","15/143","493/18670",{"v":5.90622516327779e-06,"d":"5.91E-06"},{"v":4.20922525720924e-05,"d":"4.21E-05"},{"v":1.9592555675069e-05,"d":"1.96E-05"},"PIK3CG/PRKCB/MCHR1/F2/MTNR1B/CNR1/ESR1/VDR/AVPR1A/IL2/FGF2/AGTR1/CASR/CCR5/ATP2A1",15]
["GO:0001893","maternal placenta development","5/143","35/18670",{"v":6.63014253039152e-06,"d":"6.63E-06"},{"v":4.71683953655973e-05,"d":"4.72E-05"},{"v":2.1955332771068e-05,"d":"2.20E-05"},"PTGS2/MAPK1/MAPK3/AKT1/VDR",5]
["GO:0050804","modulation of chemical synaptic transmission","14/143","436/18670",{"v":6.68552439351608e-06,"d":"6.69E-06"},{"v":4.74789521841282e-05,"d":"4.75E-05"},{"v":2.20998867301824e-05,"d":"2.21E-05"},"GSK3B/PTGS2/MAPK1/PRKCB/MTOR/STAT3/HRH1/CNR1/PLAT/TNF/HRAS/PRKCZ/ADRB2/IL1B",14]
["GO:0034754","cellular hormone metabolic process","8/143","129/18670",{"v":6.79874777469063e-06,"d":"6.80E-06"},{"v":4.80682223729243e-05,"d":"4.81E-05"},{"v":2.23741725732095e-05,"d":"2.24E-05"},"CYP19A1/ESR1/AKR1B1/SHH/TTR/CYP3A4/CYP26B1/RBP4",8]
["GO:0008406","gonad development","10/143","217/18670",{"v":6.80412337442827e-06,"d":"6.80E-06"},{"v":4.80682223729243e-05,"d":"4.81E-05"},{"v":2.23741725732095e-05,"d":"2.24E-05"},"AR/REN/INSR/CYP19A1/NOS3/ESR1/CASP3/VEGFA/SIRT1/ICAM1",10]
["GO:0050920","regulation of chemotaxis","10/143","217/18670",{"v":6.80412337442827e-06,"d":"6.80E-06"},{"v":4.80682223729243e-05,"d":"4.81E-05"},{"v":2.23741725732095e-05,"d":"2.24E-05"},"MAPK14/FGFR1/MAPK3/CYP19A1/VEGFA/FGF2/SERPINE1/IL6/PGF/CASR",10]
["GO:0099177","regulation of trans-synaptic signaling","14/143","437/18670",{"v":6.86193513917843e-06,"d":"6.86E-06"},{"v":4.83921836992932e-05,"d":"4.84E-05"},{"v":2.2524965888739e-05,"d":"2.25E-05"},"GSK3B/PTGS2/MAPK1/PRKCB/MTOR/STAT3/HRH1/CNR1/PLAT/TNF/HRAS/PRKCZ/ADRB2/IL1B",14]
["GO:0048645","animal organ formation","6/143","61/18670",{"v":7.13577028781382e-06,"d":"7.14E-06"},{"v":5.02358228262093e-05,"d":"5.02E-05"},{"v":2.338311911247e-05,"d":"2.34E-05"},"AR/MAPK1/FGFR1/MAPK3/SHH/GLI2",6]
["GO:0032874","positive regulation of stress-activated MAPK cascade","9/143","172/18670",{"v":7.18413887015902e-06,"d":"7.18E-06"},{"v":5.04885315041731e-05,"d":"5.05E-05"},{"v":2.35007466695626e-05,"d":"2.35E-05"},"TLR4/TLR9/HMGCR/PTPN1/TNF/HRAS/VEGFA/MAP3K9/IL1B",9]
["GO:0045725","positive regulation of glycogen biosynthetic process","4/143","17/18670",{"v":7.26805031252321e-06,"d":"7.27E-06"},{"v":5.09897186570086e-05,"d":"5.10E-05"},{"v":2.37340327636898e-05,"d":"2.37E-05"},"GCK/INSR/AKT1/AKT2",4]
["GO:0007249","I-kappaB kinase/NF-kappaB signaling","11/143","269/18670",{"v":7.30004688204291e-06,"d":"7.30E-06"},{"v":5.11255878520929e-05,"d":"5.11E-05"},{"v":2.37972753940208e-05,"d":"2.38E-05"},"TLR4/TLR9/PRKCB/AKT1/IKBKB/ESR1/AVPR2/TNF/SIRT1/HMOX1/IL1B",11]
["GO:0002696","positive regulation of leukocyte activation","13/143","380/18670",{"v":7.37864309318044e-06,"d":"7.38E-06"},{"v":5.15867827999904e-05,"d":"5.16E-05"},{"v":2.40119464354022e-05,"d":"2.40E-05"},"TLR4/PIK3CA/TLR9/YES1/AKT1/PIK3R1/IL2/SHH/DPP4/IL6/PRKCZ/GLI2/IL1B",13]
["GO:0070304","positive regulation of stress-activated protein kinase signaling cascade","9/143","173/18670",{"v":7.52960272573244e-06,"d":"7.53E-06"},{"v":5.25514341961464e-05,"d":"5.26E-05"},{"v":2.44609598531054e-05,"d":"2.45E-05"},"TLR4/TLR9/HMGCR/PTPN1/TNF/HRAS/VEGFA/MAP3K9/IL1B",9]
["GO:0006007","glucose catabolic process","5/143","36/18670",{"v":7.65227376468063e-06,"d":"7.65E-06"},{"v":5.32240621983285e-05,"d":"5.32E-05"},{"v":2.47740460097275e-05,"d":"2.48E-05"},"GCK/HK2/HK1/GAPDH/TP53",5]
["GO:0010573","vascular endothelial growth factor production","5/143","36/18670",{"v":7.65227376468063e-06,"d":"7.65E-06"},{"v":5.32240621983285e-05,"d":"5.32E-05"},{"v":2.47740460097275e-05,"d":"2.48E-05"},"PTGS2/IL6/HIF1A/EIF2AK3/IL1B",5]
["GO:0002526","acute inflammatory response","10/143","220/18670",{"v":7.67746976637895e-06,"d":"7.68E-06"},{"v":5.33077146042915e-05,"d":"5.33E-05"},{"v":2.48129834464536e-05,"d":"2.48E-05"},"PTGS2/PIK3CG/F2/STAT3/CNR1/PPARG/TNF/IL6/ICAM1/IL1B",10]
["GO:1901216","positive regulation of neuron death","7/143","94/18670",{"v":7.8362129732715e-06,"d":"7.84E-06"},{"v":5.4316763896923e-05,"d":"5.43E-05"},{"v":2.52826626210454e-05,"d":"2.53E-05"},"GSK3B/TLR4/MTOR/CASP3/TNF/FOS/TP53",7]
["GO:0055025","positive regulation of cardiac muscle tissue development","6/143","62/18670",{"v":7.8508569846405e-06,"d":"7.85E-06"},{"v":5.43252462800423e-05,"d":"5.43E-05"},{"v":2.52866108906999e-05,"d":"2.53E-05"},"MAPK14/MAPK1/FGFR1/MTOR/FGF2/PARP2",6]
["GO:0046651","lymphocyte proliferation","11/143","272/18670",{"v":8.10669824561798e-06,"d":"8.11E-06"},{"v":5.59044540004456e-05,"d":"5.59E-05"},{"v":2.60216800137294e-05,"d":"2.60E-05"},"TLR4/TLR9/PIK3CG/CASP3/IL2/SHH/IMPDH2/IL6/PTPN22/TP53/IL1B",11]
["GO:1902105","regulation of leukocyte differentiation","11/143","272/18670",{"v":8.10669824561798e-06,"d":"8.11E-06"},{"v":5.59044540004456e-05,"d":"5.59E-05"},{"v":2.60216800137294e-05,"d":"2.60E-05"},"TLR4/TLR9/MTOR/PIK3R1/IL2/SHH/TNF/FOS/PRKCZ/GLI2/CYP26B1",11]
["GO:0061448","connective tissue development","11/143","273/18670",{"v":8.39232118152268e-06,"d":"8.39E-06"},{"v":5.77708749077785e-05,"d":"5.78E-05"},{"v":2.68904374050665e-05,"d":"2.69E-05"},"MAPK14/FGFR1/PIK3CA/MAPK3/FGF2/SIRT1/HIF1A/EIF2AK3/GLI2/CASR/FTO",11]
["GO:0044070","regulation of anion transport","7/143","95/18670",{"v":8.40589064246086e-06,"d":"8.41E-06"},{"v":5.77708749077785e-05,"d":"5.78E-05"},{"v":2.68904374050665e-05,"d":"2.69E-05"},"FGFR1/MTOR/AKT1/AVPR1A/CFTR/AKT2/IL1B",7]
["GO:0045137","development of primary sexual characteristics","10/143","223/18670",{"v":8.64614203881412e-06,"d":"8.65E-06"},{"v":5.92655527559596e-05,"d":"5.93E-05"},{"v":2.75861606597586e-05,"d":"2.76E-05"},"AR/REN/INSR/CYP19A1/NOS3/ESR1/CASP3/VEGFA/SIRT1/ICAM1",10]
["GO:0009408","response to heat","9/143","176/18670",{"v":8.65265357677178e-06,"d":"8.65E-06"},{"v":5.92655527559596e-05,"d":"5.93E-05"},{"v":2.75861606597586e-05,"d":"2.76E-05"},"GSK3B/PTGS2/MAPK1/MTOR/MAPK3/AKT1/NOS3/SIRT1/HMOX1",9]
["GO:0042307","positive regulation of protein import into nucleus","5/143","37/18670",{"v":8.79365547140422e-06,"d":"8.79E-06"},{"v":6.01295901152775e-05,"d":"6.01E-05"},{"v":2.79883415608349e-05,"d":"2.80E-05"},"MAPK14/PTGS2/MAPK1/PIK3R1/SHH",5]
["GO:0043270","positive regulation of ion transport","11/143","275/18670",{"v":8.98999054115435e-06,"d":"8.99E-06"},{"v":6.10896859126685e-05,"d":"6.11E-05"},{"v":2.84352344975236e-05,"d":"2.84E-05"},"MCHR1/F2/KCNQ1/AKT1/AVPR1A/CFTR/KCNJ11/ADRB2/CASR/ATP2A1/IL1B",11]
["GO:0006766","vitamin metabolic process","8/143","134/18670",{"v":9.0004953603162e-06,"d":"9.00E-06"},{"v":6.10896859126685e-05,"d":"6.11E-05"},{"v":2.84352344975236e-05,"d":"2.84E-05"},"FGFR1/VDR/SLC2A1/TNF/CYP3A4/CYP26B1/CTRB1/IL1B",8]
["GO:0046683","response to organophosphorus","8/143","134/18670",{"v":9.0004953603162e-06,"d":"9.00E-06"},{"v":6.10896859126685e-05,"d":"6.11E-05"},{"v":2.84352344975236e-05,"d":"2.84E-05"},"PTGS2/PIK3CG/REN/KCNQ1/CFTR/FOS/KCNJ11/IL1B",8]
["GO:0010660","regulation of muscle cell apoptotic process","7/143","96/18670",{"v":9.0095213660729e-06,"d":"9.01E-06"},{"v":6.10896859126685e-05,"d":"6.11E-05"},{"v":2.84352344975236e-05,"d":"2.84E-05"},"HMGCR/PPARG/ALOX12/SIRT1/HMOX1/TP53/NFE2L2",7]
["GO:0090277","positive regulation of peptide hormone secretion","7/143","96/18670",{"v":9.0095213660729e-06,"d":"9.01E-06"},{"v":6.10896859126685e-05,"d":"6.11E-05"},{"v":2.84352344975236e-05,"d":"2.84E-05"},"GCK/BLK/CFTR/HIF1A/CASR/NR0B2/RBP4",7]
["GO:0007252","I-kappaB phosphorylation","4/143","18/18670",{"v":9.2891168764878e-06,"d":"9.29E-06"},{"v":6.24623673023631e-05,"d":"6.25E-05"},{"v":2.90741724233488e-05,"d":"2.91E-05"},"TLR4/TLR9/AKT1/IKBKB",4]
["GO:0051023","regulation of immunoglobulin secretion","4/143","18/18670",{"v":9.2891168764878e-06,"d":"9.29E-06"},{"v":6.24623673023631e-05,"d":"6.25E-05"},{"v":2.90741724233488e-05,"d":"2.91E-05"},"IL2/TNF/IL6/RBP4",4]
["GO:0060749","mammary gland alveolus development","4/143","18/18670",{"v":9.2891168764878e-06,"d":"9.29E-06"},{"v":6.24623673023631e-05,"d":"6.25E-05"},{"v":2.90741724233488e-05,"d":"2.91E-05"},"AR/ESR1/VEGFA/HIF1A",4]
["GO:0061377","mammary gland lobule development","4/143","18/18670",{"v":9.2891168764878e-06,"d":"9.29E-06"},{"v":6.24623673023631e-05,"d":"6.25E-05"},{"v":2.90741724233488e-05,"d":"2.91E-05"},"AR/ESR1/VEGFA/HIF1A",4]
["GO:0070875","positive regulation of glycogen metabolic process","4/143","18/18670",{"v":9.2891168764878e-06,"d":"9.29E-06"},{"v":6.24623673023631e-05,"d":"6.25E-05"},{"v":2.90741724233488e-05,"d":"2.91E-05"},"GCK/INSR/AKT1/AKT2",4]
["GO:0014706","striated muscle tissue development","13/143","390/18670",{"v":9.74246176447873e-06,"d":"9.74E-06"},{"v":6.54021313807792e-05,"d":"6.54E-05"},{"v":3.04425356697511e-05,"d":"3.04E-05"},"MAPK14/MAPK1/FGFR1/HMGCR/MTOR/PPARA/SHH/VEGFA/FGF2/FOS/PARP2/CYP26B1/RBP4",13]
["GO:0015849","organic acid transport","12/143","333/18670",{"v":1.00068717800132e-05,"d":"1.00E-05"},{"v":6.69550693644517e-05,"d":"6.70E-05"},{"v":3.11653770965177e-05,"d":"3.12E-05"},"NOS2/AKT1/PPARG/AVPR1A/PPARA/FABP4/AKT2/ACE/CASR/PRKAA2/ACACB/IL1B",12]
["GO:0046942","carboxylic acid transport","12/143","333/18670",{"v":1.00068717800132e-05,"d":"1.00E-05"},{"v":6.69550693644517e-05,"d":"6.70E-05"},{"v":3.11653770965177e-05,"d":"3.12E-05"},"NOS2/AKT1/PPARG/AVPR1A/PPARA/FABP4/AKT2/ACE/CASR/PRKAA2/ACACB/IL1B",12]
["GO:0052547","regulation of peptidase activity","14/143","452/18670",{"v":1.00520890379454e-05,"d":"1.01E-05"},{"v":6.71466277650217e-05,"d":"6.71E-05"},{"v":3.12545412157762e-05,"d":"3.13E-05"},"MAPK14/PTGS2/MMP9/MAPK3/STAT3/AKT1/PPARG/ALOX12/TNF/VEGFA/SERPINE1/SIRT1/GAPDH/EIF2AK3",14]
["GO:2001243","negative regulation of intrinsic apoptotic signaling pathway","7/143","98/18670",{"v":1.03249914662308e-05,"d":"1.03E-05"},{"v":6.88559562690319e-05,"d":"6.89E-05"},{"v":3.20501772731348e-05,"d":"3.21E-05"},"PTGS2/MMP9/AKT1/PTPN1/SIRT1/HIF1A/NFE2L2",7]
["GO:0051054","positive regulation of DNA metabolic process","10/143","228/18670",{"v":1.04959331361645e-05,"d":"1.05E-05"},{"v":6.98808179855166e-05,"d":"6.99E-05"},{"v":3.25272166096512e-05,"d":"3.25E-05"},"MAPK1/FGFR1/MAPK3/AKT1/IL2/HRAS/FGF2/SIRT1/IL6/GLI2",10]
["GO:0009205","purine ribonucleoside triphosphate metabolic process","12/143","335/18670",{"v":1.06261543765966e-05,"d":"1.06E-05"},{"v":7.06316468250626e-05,"d":"7.06E-05"},{"v":3.28767026775697e-05,"d":"3.29E-05"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0030522","intracellular receptor signaling pathway","11/143","280/18670",{"v":1.06491195903882e-05,"d":"1.06E-05"},{"v":7.06682559047401e-05,"d":"7.07E-05"},{"v":3.28937429970576e-05,"d":"3.29E-05"},"AR/TLR4/STAT3/ESR1/VDR/PPARG/PPARA/SIRT1/PTPN22/RXRG/CYP26B1",11]
["GO:1904591","positive regulation of protein import","5/143","39/18670",{"v":1.14730879621113e-05,"d":"1.15E-05"},{"v":7.60115549437424e-05,"d":"7.60E-05"},{"v":3.53808725164601e-05,"d":"3.54E-05"},"MAPK14/PTGS2/MAPK1/PIK3R1/SHH",5]
["GO:0010888","negative regulation of lipid storage","4/143","19/18670",{"v":1.16963228789761e-05,"d":"1.17E-05"},{"v":7.71119137037382e-05,"d":"7.71E-05"},{"v":3.58930532373859e-05,"d":"3.59E-05"},"PPARG/PPARA/TNF/IL6",4]
["GO:0060252","positive regulation of glial cell proliferation","4/143","19/18670",{"v":1.16963228789761e-05,"d":"1.17E-05"},{"v":7.71119137037382e-05,"d":"7.71E-05"},{"v":3.58930532373859e-05,"d":"3.59E-05"},"MTOR/TNF/IL6/IL1B",4]
["GO:1902176","negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway","4/143","19/18670",{"v":1.16963228789761e-05,"d":"1.17E-05"},{"v":7.71119137037382e-05,"d":"7.71E-05"},{"v":3.58930532373859e-05,"d":"3.59E-05"},"AKT1/SIRT1/HIF1A/NFE2L2",4]
["GO:0010657","muscle cell apoptotic process","7/143","100/18670",{"v":1.17958418567993e-05,"d":"1.18E-05"},{"v":7.76415737175991e-05,"d":"7.76E-05"},{"v":3.6139592509492e-05,"d":"3.61E-05"},"HMGCR/PPARG/ALOX12/SIRT1/HMOX1/TP53/NFE2L2",7]
["GO:0009167","purine ribonucleoside monophosphate metabolic process","12/143","340/18670",{"v":1.23235408271253e-05,"d":"1.23E-05"},{"v":8.09832682925378e-05,"d":"8.10E-05"},{"v":3.76950411492726e-05,"d":"3.77E-05"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0046365","monosaccharide catabolic process","6/143","67/18670",{"v":1.23509510982695e-05,"d":"1.24E-05"},{"v":8.10318477241408e-05,"d":"8.10E-05"},{"v":3.77176532728864e-05,"d":"3.77E-05"},"GCK/HK2/HK1/GAPDH/SORD/TP53",6]
["GO:0043401","steroid hormone mediated signaling pathway","9/143","184/18670",{"v":1.23722915485486e-05,"d":"1.24E-05"},{"v":8.10405116319169e-05,"d":"8.10E-05"},{"v":3.77216860362833e-05,"d":"3.77E-05"},"AR/ESR1/VDR/PPARG/PPARA/HNF4A/SIRT1/RXRG/NR0B2",9]
["GO:0007631","feeding behavior","7/143","101/18670",{"v":1.25938974853216e-05,"d":"1.26E-05"},{"v":8.22259629364226e-05,"d":"8.22E-05"},{"v":3.82734745309435e-05,"d":"3.83E-05"},"REN/MCHR1/MTOR/STAT3/CNR1/FOS/MC4R",7]
["GO:0032649","regulation of interferon-gamma production","7/143","101/18670",{"v":1.25938974853216e-05,"d":"1.26E-05"},{"v":8.22259629364226e-05,"d":"8.22E-05"},{"v":3.82734745309435e-05,"d":"3.83E-05"},"TLR4/TLR9/IL2/TNF/HRAS/PTPN22/IL1B",7]
["GO:0009126","purine nucleoside monophosphate metabolic process","12/143","341/18670",{"v":1.26901430085832e-05,"d":"1.27E-05"},{"v":8.25879403516795e-05,"d":"8.26E-05"},{"v":3.84419630823555e-05,"d":"3.84E-05"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0009199","ribonucleoside triphosphate metabolic process","12/143","341/18670",{"v":1.26901430085832e-05,"d":"1.27E-05"},{"v":8.25879403516795e-05,"d":"8.26E-05"},{"v":3.84419630823555e-05,"d":"3.84E-05"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:1903708","positive regulation of hemopoiesis","9/143","185/18670",{"v":1.29212747642166e-05,"d":"1.29E-05"},{"v":8.39571753540107e-05,"d":"8.40E-05"},{"v":3.90792968284999e-05,"d":"3.91E-05"},"MAPK14/STAT3/IL2/SHH/TNF/FOS/PRKCZ/HIF1A/GLI2",9]
["GO:0006734","NADH metabolic process","5/143","40/18670",{"v":1.30316857927266e-05,"d":"1.30E-05"},{"v":8.44036225423314e-05,"d":"8.44E-05"},{"v":3.92871032740725e-05,"d":"3.93E-05"},"GCK/HK2/HK1/GAPDH/TP53",5]
["GO:0071470","cellular response to osmotic stress","5/143","40/18670",{"v":1.30316857927266e-05,"d":"1.30E-05"},{"v":8.44036225423314e-05,"d":"8.44E-05"},{"v":3.92871032740725e-05,"d":"3.93E-05"},"PTGS2/MAPK10/CASP3/SLC2A1/AKR1B1",5]
["GO:0009144","purine nucleoside triphosphate metabolic process","12/143","342/18670",{"v":1.30662577656044e-05,"d":"1.31E-05"},{"v":8.44923505354098e-05,"d":"8.45E-05"},{"v":3.93284032292448e-05,"d":"3.93E-05"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0002683","negative regulation of immune system process","14/143","463/18670",{"v":1.31654907522104e-05,"d":"1.32E-05"},{"v":8.49982560844463e-05,"d":"8.50E-05"},{"v":3.9563885581225e-05,"d":"3.96E-05"},"TLR4/TLR9/AKT1/CYP19A1/PIK3R1/CNR1/PPARG/CASP3/IL2/SHH/TNF/HMOX1/PTPN22/NFE2L2",14]
["GO:0016239","positive regulation of macroautophagy","6/143","68/18670",{"v":1.3461447202121e-05,"d":"1.35E-05"},{"v":8.67706023474294e-05,"d":"8.68E-05"},{"v":4.03888543275168e-05,"d":"4.04E-05"},"MAPK3/SIRT1/HMOX1/HIF1A/ADRB2/PRKAA2",6]
["GO:0032091","negative regulation of protein binding","7/143","103/18670",{"v":1.43244732690936e-05,"d":"1.43E-05"},{"v":9.2186753248475e-05,"d":"9.22E-05"},{"v":4.29098939865743e-05,"d":"4.29E-05"},"GSK3B/MAPK8/MAPK3/AKT1/PPARA/ACE/ADRB2",7]
["GO:0006606","protein import into nucleus","8/143","143/18670",{"v":1.44863337996786e-05,"d":"1.45E-05"},{"v":9.26393036668231e-05,"d":"9.26E-05"},{"v":4.31205412844845e-05,"d":"4.31E-05"},"MAPK14/PTGS2/MAPK1/STAT3/AKT1/PIK3R1/SHH/TP53",8]
["GO:0031056","regulation of histone modification","8/143","143/18670",{"v":1.44863337996786e-05,"d":"1.45E-05"},{"v":9.26393036668231e-05,"d":"9.26E-05"},{"v":4.31205412844845e-05,"d":"4.31E-05"},"MAPK8/MAPK3/VEGFA/SIRT1/SETD7/OGT/TP53/IL1B",8]
["GO:0106106","cold-induced thermogenesis","8/143","143/18670",{"v":1.44863337996786e-05,"d":"1.45E-05"},{"v":9.26393036668231e-05,"d":"9.26E-05"},{"v":4.31205412844845e-05,"d":"4.31E-05"},"TLR4/IGF1R/ADRB3/LNPEP/FABP4/VEGFA/OGT/ADRB2",8]
["GO:0120161","regulation of cold-induced thermogenesis","8/143","143/18670",{"v":1.44863337996786e-05,"d":"1.45E-05"},{"v":9.26393036668231e-05,"d":"9.26E-05"},{"v":4.31205412844845e-05,"d":"4.31E-05"},"TLR4/IGF1R/ADRB3/LNPEP/FABP4/VEGFA/OGT/ADRB2",8]
["GO:0002374","cytokine secretion involved in immune response","4/143","20/18670",{"v":1.45335760853832e-05,"d":"1.45E-05"},{"v":9.26486866041439e-05,"d":"9.26E-05"},{"v":4.3124908732426e-05,"d":"4.31E-05"},"MAPK14/MAPK3/HK1/TNF",4]
["GO:0043369","CD4-positive or CD8-positive, alpha-beta T cell lineage commitment","4/143","20/18670",{"v":1.45335760853832e-05,"d":"1.45E-05"},{"v":9.26486866041439e-05,"d":"9.26E-05"},{"v":4.3124908732426e-05,"d":"4.31E-05"},"MTOR/STAT3/SHH/IL6",4]
["GO:0006367","transcription initiation from RNA polymerase II promoter","9/143","188/18670",{"v":1.46946915299305e-05,"d":"1.47E-05"},{"v":9.32977549545341e-05,"d":"9.33E-05"},{"v":4.34270286479655e-05,"d":"4.34E-05"},"AR/ESR1/VDR/PPARG/PPARA/HNF4A/RXRG/TP53/NR0B2",9]
["GO:0043122","regulation of I-kappaB kinase/NF-kappaB signaling","10/143","237/18670",{"v":1.4694824498121e-05,"d":"1.47E-05"},{"v":9.32977549545341e-05,"d":"9.33E-05"},{"v":4.34270286479655e-05,"d":"4.34E-05"},"TLR4/TLR9/PRKCB/AKT1/IKBKB/ESR1/TNF/SIRT1/HMOX1/IL1B",10]
["GO:0061028","establishment of endothelial barrier","5/143","41/18670",{"v":1.47506331943927e-05,"d":"1.48E-05"},{"v":9.32977549545341e-05,"d":"9.33E-05"},{"v":4.34270286479655e-05,"d":"4.34E-05"},"IKBKB/TNF/VEGFA/ICAM1/IL1B",5]
["GO:0150077","regulation of neuroinflammatory response","5/143","41/18670",{"v":1.47506331943927e-05,"d":"1.48E-05"},{"v":9.32977549545341e-05,"d":"9.33E-05"},{"v":4.34270286479655e-05,"d":"4.34E-05"},"PTGS2/MMP9/TNF/IL6/IL1B",5]
["GO:1902893","regulation of pri-miRNA transcription by RNA polymerase II","5/143","41/18670",{"v":1.47506331943927e-05,"d":"1.48E-05"},{"v":9.32977549545341e-05,"d":"9.33E-05"},{"v":4.34270286479655e-05,"d":"4.34E-05"},"STAT3/PPARA/FOS/HIF1A/TP53",5]
["GO:0071356","cellular response to tumor necrosis factor","11/143","291/18670",{"v":1.52634547718271e-05,"d":"1.53E-05"},{"v":9.63907408991513e-05,"d":"9.64E-05"},{"v":4.48667116209384e-05,"d":"4.49E-05"},"MAPK14/MAPK1/MAPK3/AKT1/IKBKB/TNF/FABP4/SIRT1/KCNJ11/ICAM1/NFE2L2",11]
["GO:0060537","muscle tissue development","13/143","408/18670",{"v":1.57176677622249e-05,"d":"1.57E-05"},{"v":9.91045468870507e-05,"d":"9.91E-05"},{"v":4.61298988266644e-05,"d":"4.61E-05"},"MAPK14/MAPK1/FGFR1/HMGCR/MTOR/PPARA/SHH/VEGFA/FGF2/FOS/PARP2/CYP26B1/RBP4",13]
["GO:0051402","neuron apoptotic process","10/143","239/18670",{"v":1.58029755848692e-05,"d":"1.58E-05"},{"v":9.94874730444023e-05,"d":"9.95E-05"},{"v":4.63081383267839e-05,"d":"4.63E-05"},"PIK3CA/MTNR1B/CASP3/TNF/HRAS/AKT2/GAPDH/HMOX1/HIF1A/TP53",10]
["GO:0033138","positive regulation of peptidyl-serine phosphorylation","7/143","105/18670",{"v":1.62472624282358e-05,"d":"1.62E-05"},0.000102125649548911,{"v":4.75361225017032e-05,"d":"4.75E-05"},"BRAF/PTGS2/PIK3CA/AKT1/TNF/VEGFA/IL6",7]
["GO:0030217","T cell differentiation","10/143","240/18670",{"v":1.63835244092994e-05,"d":"1.64E-05"},0.000102822491176502,{"v":4.78604793025638e-05,"d":"4.79E-05"},"MTOR/STAT3/IL2/SHH/IL6/PRKCZ/GLI2/PTPN22/CYP26B1/TP53",10]
["GO:0007517","muscle organ development","13/143","410/18670",{"v":1.65481646949969e-05,"d":"1.65E-05"},0.000103695001060909,{"v":4.82666038847066e-05,"d":"4.83E-05"},"MAPK14/MAPK1/FGFR1/HMGCR/MTOR/PPARA/SHH/FGF2/FOS/SIRT1/PARP2/CYP26B1/RBP4",13]
["GO:0010677","negative regulation of cellular carbohydrate metabolic process","5/143","42/18670",{"v":1.66413025120254e-05,"d":"1.66E-05"},0.000103956778655368,{"v":4.83884527234006e-05,"d":"4.84E-05"},"GSK3B/GCK/CLK2/STAT3/PPARA",5]
["GO:0042149","cellular response to glucose starvation","5/143","42/18670",{"v":1.66413025120254e-05,"d":"1.66E-05"},{"v":0.000103956778655368,"d":"1.04E-04"},{"v":4.83884527234006e-05,"d":"4.84E-05"},"SLC2A1/EIF2AK3/TP53/PRKAA2/NFE2L2",5]
["GO:0051384","response to glucocorticoid","8/143","146/18670",{"v":1.68478387521822e-05,"d":"1.68E-05"},{"v":0.000105084824759374,"d":"1.05E-04"},{"v":4.89135209900352e-05,"d":"4.89E-05"},"PTGS2/CASP3/AVPR1A/TNF/FOS/IL6/FOXO1/ICAM1",8]
["GO:0002286","T cell activation involved in immune response","7/143","106/18670",{"v":1.72858007801413e-05,"d":"1.73E-05"},{"v":0.000107650648550787,"d":"1.08E-04"},{"v":5.01078273626767e-05,"d":"5.01E-05"},"MTOR/STAT3/IL2/IL6/PRKCZ/TP53/ICAM1",7]
["GO:0002262","myeloid cell homeostasis","8/143","147/18670",{"v":1.77035613461768e-05,"d":"1.77E-05"},{"v":0.000109914135474423,"d":"1.10E-04"},{"v":5.11614058922449e-05,"d":"5.12E-05"},"MAPK14/STAT3/CASP3/VEGFA/HMOX1/IL6/HIF1A/HCAR2",8]
["GO:0010212","response to ionizing radiation","8/143","147/18670",{"v":1.77035613461768e-05,"d":"1.77E-05"},{"v":0.000109914135474423,"d":"1.10E-04"},{"v":5.11614058922449e-05,"d":"5.12E-05"},"MAPK14/NAMPT/CLK2/CASP3/HRAS/SIRT1/TP53/ICAM1",8]
["GO:2000269","regulation of fibroblast apoptotic process","4/143","21/18670",{"v":1.78466430529785e-05,"d":"1.78E-05"},{"v":0.000110632788787836,"d":"1.11E-04"},{"v":5.14959153136641e-05,"d":"5.15E-05"},"STK17B/PIK3CA/PIK3CG/TP53",4]
["GO:0030098","lymphocyte differentiation","12/143","353/18670",{"v":1.78938570207768e-05,"d":"1.79E-05"},{"v":0.00011075586119282,"d":"1.11E-04"},{"v":5.15532014601489e-05,"d":"5.16E-05"},"TLR9/MTOR/STAT3/PIK3R1/IL2/SHH/IL6/PRKCZ/GLI2/PTPN22/CYP26B1/TP53",12]
["GO:0009161","ribonucleoside monophosphate metabolic process","12/143","354/18670",{"v":1.84015249295503e-05,"d":"1.84E-05"},{"v":0.00011372423345774,"d":"1.14E-04"},{"v":5.29348808740781e-05,"d":"5.29E-05"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0031279","regulation of cyclase activity","5/143","43/18670",{"v":1.87155088266382e-05,"d":"1.87E-05"},{"v":0.000115283112780725,"d":"1.15E-04"},{"v":5.36604877983923e-05,"d":"5.37E-05"},"NOS2/MAPK14/MAPK8/MAPK3/NOS3",5]
["GO:0034198","cellular response to amino acid starvation","5/143","43/18670",{"v":1.87155088266382e-05,"d":"1.87E-05"},{"v":0.000115283112780725,"d":"1.15E-04"},{"v":5.36604877983923e-05,"d":"5.37E-05"},"MAPK1/MAPK8/MTOR/MAPK3/EIF2AK3",5]
["GO:0006635","fatty acid beta-oxidation","6/143","72/18670",{"v":1.87392016328352e-05,"d":"1.87E-05"},{"v":0.000115283112780725,"d":"1.15E-04"},{"v":5.36604877983923e-05,"d":"5.37E-05"},"MTOR/AKT1/CNR1/PPARA/AKT2/ACACB",6]
["GO:0009062","fatty acid catabolic process","7/143","108/18670",{"v":1.95278085720918e-05,"d":"1.95E-05"},{"v":0.000119952305159071,"d":"1.20E-04"},{"v":5.58338428944084e-05,"d":"5.58E-05"},"MTOR/AKT1/CNR1/PPARA/AKT2/LIPE/ACACB",7]
["GO:0008203","cholesterol metabolic process","8/143","150/18670",{"v":2.049306533981e-05,"d":"2.05E-05"},{"v":0.000125690800750835,"d":"1.26E-04"},{"v":5.85049233784049e-05,"d":"5.85E-05"},"HMGCR/PON1/CFTR/LIPE/NR0B2/PRKAA2/ACACB/CETP",8]
["GO:0014002","astrocyte development","5/143","44/18670",{"v":2.09855111856177e-05,"d":"2.10E-05"},{"v":0.000128132145483295,"d":"1.28E-04"},{"v":5.96412888535202e-05,"d":"5.96E-05"},"TLR4/BACE2/TNF/IL6/IL1B",5]
["GO:0044060","regulation of endocrine process","5/143","44/18670",{"v":2.09855111856177e-05,"d":"2.10E-05"},{"v":0.000128132145483295,"d":"1.28E-04"},{"v":5.96412888535202e-05,"d":"5.96E-05"},"FGFR1/REN/AGTR1/HCAR2/IL1B",5]
["GO:0097237","cellular response to toxic substance","10/143","247/18670",{"v":2.09860702706088e-05,"d":"2.10E-05"},{"v":0.000128132145483295,"d":"1.28E-04"},{"v":5.96412888535202e-05,"d":"5.96E-05"},"PTGS2/NOS3/TNF/SIRT1/HMOX1/KCNJ11/IL6/FOXO1/GSR/NFE2L2",10]
["GO:0006925","inflammatory cell apoptotic process","4/143","22/18670",{"v":2.16830783130578e-05,"d":"2.17E-05"},{"v":0.000131791442959847,"d":"1.32E-04"},{"v":6.13445711717613e-05,"d":"6.13E-05"},"SIRT1/IL6/CCR5/HCAR2",4]
["GO:0048305","immunoglobulin secretion","4/143","22/18670",{"v":2.16830783130578e-05,"d":"2.17E-05"},{"v":0.000131791442959847,"d":"1.32E-04"},{"v":6.13445711717613e-05,"d":"6.13E-05"},"IL2/TNF/IL6/RBP4",4]
["GO:1901522","positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus","4/143","22/18670",{"v":2.16830783130578e-05,"d":"2.17E-05"},{"v":0.000131791442959847,"d":"1.32E-04"},{"v":6.13445711717613e-05,"d":"6.13E-05"},"VEGFA/HIF1A/TP53/NFE2L2",4]
["GO:0014015","positive regulation of gliogenesis","6/143","74/18670",{"v":2.19418449096334e-05,"d":"2.19E-05"},{"v":0.000132964952386521,"d":"1.33E-04"},{"v":6.18908011160476e-05,"d":"6.19E-05"},"MTOR/PPARG/SHH/TNF/IL6/IL1B",6]
["GO:0032677","regulation of interleukin-8 production","6/143","74/18670",{"v":2.19418449096334e-05,"d":"2.19E-05"},{"v":0.000132964952386521,"d":"1.33E-04"},{"v":6.18908011160476e-05,"d":"6.19E-05"},"TLR4/TLR9/TNF/SERPINE1/PTPN22/IL1B",6]
["GO:0006352","DNA-templated transcription, initiation","10/143","249/18670",{"v":2.24894295479924e-05,"d":"2.25E-05"},{"v":0.000136079537832994,"d":"1.36E-04"},{"v":6.33405379449395e-05,"d":"6.33E-05"},"AR/MAPK3/ESR1/VDR/PPARG/PPARA/HNF4A/RXRG/TP53/NR0B2",10]
["GO:0001890","placenta development","8/143","152/18670",{"v":2.2550592874213e-05,"d":"2.26E-05"},{"v":0.000136245970081812,"d":"1.36E-04"},{"v":6.34180066690357e-05,"d":"6.34E-05"},"MAPK14/PTGS2/MAPK1/MAPK3/AKT1/VDR/PPARG/HIF1A",8]
["GO:0009141","nucleoside triphosphate metabolic process","12/143","362/18670",{"v":2.29365592683447e-05,"d":"2.29E-05"},{"v":0.000138371373946735,"d":"1.38E-04"},{"v":6.44073120877513e-05,"d":"6.44E-05"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0050866","negative regulation of cell activation","9/143","199/18670",{"v":2.30845060271033e-05,"d":"2.31E-05"},{"v":0.000139056667258503,"d":"1.39E-04"},{"v":6.47262935283754e-05,"d":"6.47E-05"},"F2/NOS3/CNR1/CASP3/ALOX12/IL2/SHH/HMOX1/PTPN22",9]
["GO:0046034","ATP metabolic process","11/143","305/18670",{"v":2.35761479489694e-05,"d":"2.36E-05"},{"v":0.000141807201927828,"d":"1.42E-04"},{"v":6.60065767242594e-05,"d":"6.60E-05"},"GCK/INSR/STAT3/HK2/HK1/PPARA/GAPDH/HIF1A/OGT/TP53/PRKAA2",11]
["GO:0006984","ER-nucleus signaling pathway","5/143","46/18670",{"v":2.61641650684083e-05,"d":"2.62E-05"},{"v":0.000156675355320883,"d":"1.57E-04"},{"v":7.29272118848502e-05,"d":"7.29E-05"},"GSK3B/PTPN1/EIF2AK3/TP53/NFE2L2",5]
["GO:1904036","negative regulation of epithelial cell apoptotic process","5/143","46/18670",{"v":2.61641650684083e-05,"d":"2.62E-05"},{"v":0.000156675355320883,"d":"1.57E-04"},{"v":7.29272118848502e-05,"d":"7.29E-05"},"MTOR/SERPINE1/HMOX1/ICAM1/NFE2L2",5]
["GO:1990928","response to amino acid starvation","5/143","46/18670",{"v":2.61641650684083e-05,"d":"2.62E-05"},{"v":0.000156675355320883,"d":"1.57E-04"},{"v":7.29272118848502e-05,"d":"7.29E-05"},"MAPK1/MAPK8/MTOR/MAPK3/EIF2AK3",5]
["GO:0051052","regulation of DNA metabolic process","13/143","429/18670",{"v":2.65748012513999e-05,"d":"2.66E-05"},{"v":0.000158899254749877,"d":"1.59E-04"},{"v":7.39623637409716e-05,"d":"7.40E-05"},"MAPK1/FGFR1/PIK3CA/MAPK3/AKT1/PPARG/IL2/HRAS/FGF2/SIRT1/IL6/GLI2/TP53",13]
["GO:0030856","regulation of epithelial cell differentiation","8/143","156/18670",{"v":2.71885602719693e-05,"d":"2.72E-05"},{"v":0.000162329339204914,"d":"1.62E-04"},{"v":7.55589549554807e-05,"d":"7.56E-05"},"GSK3B/MMP9/IKBKB/VDR/TNF/VEGFA/SERPINE1/IL1B",8]
["GO:0002688","regulation of leukocyte chemotaxis","7/143","114/18670",{"v":2.77386583650847e-05,"d":"2.77E-05"},{"v":0.000164884124907288,"d":"1.65E-04"},{"v":7.67481234616301e-05,"d":"7.67E-05"},"MAPK14/MAPK3/CYP19A1/VEGFA/SERPINE1/IL6/PGF",7]
["GO:0006690","icosanoid metabolic process","7/143","114/18670",{"v":2.77386583650847e-05,"d":"2.77E-05"},{"v":0.000164884124907288,"d":"1.65E-04"},{"v":7.67481234616301e-05,"d":"7.67E-05"},"PTGS2/MAPK3/ALOX12/AVPR1A/PON1/SIRT1/IL1B",7]
["GO:0042035","regulation of cytokine biosynthetic process","7/143","114/18670",{"v":2.77386583650847e-05,"d":"2.77E-05"},{"v":0.000164884124907288,"d":"1.65E-04"},{"v":7.67481234616301e-05,"d":"7.67E-05"},"TLR4/TLR9/STAT3/TNF/HMOX1/IL6/IL1B",7]
["GO:0007187","G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger","10/143","256/18670",{"v":2.85027739088675e-05,"d":"2.85E-05"},{"v":0.000169177754813924,"d":"1.69E-04"},{"v":7.87466666103919e-05,"d":"7.87E-05"},"ADRB3/MCHR1/MTNR1B/HRH1/CNR1/AVPR2/GCGR/ADRB2/CASR/MC4R",10]
["GO:0048806","genitalia development","5/143","47/18670",{"v":2.909956088794e-05,"d":"2.91E-05"},{"v":0.000171963536458951,"d":"1.72E-04"},{"v":8.00433561112756e-05,"d":"8.00E-05"},"AR/CYP19A1/ESR1/SHH/RBP4",5]
["GO:0050435","amyloid-beta metabolic process","5/143","47/18670",{"v":2.909956088794e-05,"d":"2.91E-05"},{"v":0.000171963536458951,"d":"1.72E-04"},{"v":8.00433561112756e-05,"d":"8.00E-05"},"BACE2/REN/CASP3/TNF/ACE",5]
["GO:0060986","endocrine hormone secretion","5/143","47/18670",{"v":2.909956088794e-05,"d":"2.91E-05"},{"v":0.000171963536458951,"d":"1.72E-04"},{"v":8.00433561112756e-05,"d":"8.00E-05"},"FGFR1/REN/AGTR1/HCAR2/IL1B",5]
["GO:1904375","regulation of protein localization to cell periphery","7/143","115/18670",{"v":2.93494456285393e-05,"d":"2.93E-05"},{"v":0.000173187399277445,"d":"1.73E-04"},{"v":8.06130238991642e-05,"d":"8.06E-05"},"AR/AKT1/PIK3R1/TNF/HRAS/KCNJ11/PRKCZ",7]
["GO:0051098","regulation of binding","12/143","373/18670",{"v":3.07481073126539e-05,"d":"3.07E-05"},{"v":0.000181176620671941,"d":"1.81E-04"},{"v":8.43317430317177e-05,"d":"8.43E-05"},"GSK3B/MAPK8/MMP9/MAPK3/AKT1/PPARG/PPARA/PON1/ACE/PRMT7/HMOX1/ADRB2",12]
["GO:0009110","vitamin biosynthetic process","4/143","24/18670",{"v":3.11247966278493e-05,"d":"3.11E-05"},{"v":0.000182597270217337,"d":"1.83E-04"},{"v":8.49930085523801e-05,"d":"8.50E-05"},"VDR/TNF/CYP3A4/IL1B",4]
["GO:0044346","fibroblast apoptotic process","4/143","24/18670",{"v":3.11247966278493e-05,"d":"3.11E-05"},{"v":0.000182597270217337,"d":"1.83E-04"},{"v":8.49930085523801e-05,"d":"8.50E-05"},"STK17B/PIK3CA/PIK3CG/TP53",4]
["GO:0046697","decidualization","4/143","24/18670",{"v":3.11247966278493e-05,"d":"3.11E-05"},{"v":0.000182597270217337,"d":"1.83E-04"},{"v":8.49930085523801e-05,"d":"8.50E-05"},"PTGS2/MAPK1/MAPK3/VDR",4]
["GO:0002673","regulation of acute inflammatory response","8/143","159/18670",{"v":3.11696427174357e-05,"d":"3.12E-05"},{"v":0.000182597270217337,"d":"1.83E-04"},{"v":8.49930085523801e-05,"d":"8.50E-05"},"PTGS2/PIK3CG/F2/CNR1/PPARG/TNF/IL6/IL1B",8]
["GO:0090257","regulation of muscle system process","10/143","259/18670",{"v":3.14738774135573e-05,"d":"3.15E-05"},{"v":0.000184113086372948,"d":"1.84E-04"},{"v":8.56985709921929e-05,"d":"8.57E-05"},"PTGS2/PIK3CG/MTOR/KCNQ1/NOS3/PPARA/FOXO1/ADRB2/PARP2/ATP2A1",10]
["GO:0060249","anatomical structure homeostasis","13/143","437/18670",{"v":3.21824075801941e-05,"d":"3.22E-05"},{"v":0.000187768117290743,"d":"1.88E-04"},{"v":8.73998673680128e-05,"d":"8.74E-05"},"TLR4/MAPK1/TLR9/MAPK3/NOS3/CNR1/AKR1B1/VEGFA/IL6/HIF1A/ADRB2/RBP4/MC4R",13]
["GO:0030850","prostate gland development","5/143","48/18670",{"v":3.22842415104637e-05,"d":"3.23E-05"},{"v":0.000187768117290743,"d":"1.88E-04"},{"v":8.73998673680128e-05,"d":"8.74E-05"},"AR/CYP19A1/ESR1/SHH/GLI2",5]
["GO:0101023","vascular endothelial cell proliferation","5/143","48/18670",{"v":3.22842415104637e-05,"d":"3.23E-05"},{"v":0.000187768117290743,"d":"1.88E-04"},{"v":8.73998673680128e-05,"d":"8.74E-05"},"FLT1/FGFR1/STAT3/PPARG/FGF2",5]
["GO:1905562","regulation of vascular endothelial cell proliferation","5/143","48/18670",{"v":3.22842415104637e-05,"d":"3.23E-05"},0.000187768117290743,{"v":8.73998673680128e-05,"d":"8.74E-05"},"FLT1/FGFR1/STAT3/PPARG/FGF2",5]
["GO:0009123","nucleoside monophosphate metabolic process","12/143","375/18670",{"v":3.23930691529578e-05,"d":"3.24E-05"},0.000188130766041856,{"v":8.75686684041298e-05,"d":"8.76E-05"},"GCK/INSR/STAT3/HK2/HK1/PPARA/IMPDH2/GAPDH/HIF1A/OGT/TP53/PRKAA2",12]
["GO:0007613","memory","7/143","117/18670",{"v":3.2802419996514e-05,"d":"3.28E-05"},0.000190235238031359,{"v":8.85482307250188e-05,"d":"8.85E-05"},"PTGS2/MTOR/INSR/HRH1/CNR1/SGK1/PRKCZ",7]
["GO:0032635","interleukin-6 production","8/143","161/18670",{"v":3.40858535343867e-05,"d":"3.41E-05"},0.000197395615317879,{"v":9.18811502545775e-05,"d":"9.19E-05"},"TLR4/NOS2/TLR9/STAT3/TNF/IL6/PTPN22/IL1B",8]
["GO:0031960","response to corticosteroid","8/143","162/18670",{"v":3.56274247023125e-05,"d":"3.56E-05"},0.000206028307421373,{"v":9.58993837851719e-05,"d":"9.59E-05"},"PTGS2/CASP3/AVPR1A/TNF/FOS/IL6/FOXO1/ICAM1",8]
["GO:0032757","positive regulation of interleukin-8 production","5/143","49/18670",{"v":3.5732692704656e-05,"d":"3.57E-05"},0.00020634228255128,{"v":9.6045528855521e-05,"d":"9.60E-05"},"TLR4/TLR9/TNF/SERPINE1/IL1B",5]
["GO:1902930","regulation of alcohol biosynthetic process","6/143","81/18670",{"v":3.678911030441e-05,"d":"3.68E-05"},0.000211792687256605,{"v":9.85825125310284e-05,"d":"9.86E-05"},"HMGCR/HRH1/VDR/TNF/ACACB/IL1B",6]
["GO:0051156","glucose 6-phosphate metabolic process","4/143","25/18670",{"v":3.68335108272357e-05,"d":"3.68E-05"},0.000211792687256605,{"v":9.85825125310284e-05,"d":"9.86E-05"},"GCK/HK2/HK1/TKT",4]
["GO:0060571","morphogenesis of an epithelial fold","4/143","25/18670",{"v":3.68335108272357e-05,"d":"3.68E-05"},0.000211792687256605,{"v":9.85825125310284e-05,"d":"9.86E-05"},"AR/SHH/HIF1A/GLI2",4]
["GO:0051170","import into nucleus","8/143","163/18670",{"v":3.72268629592003e-05,"d":"3.72E-05"},0.000213750838665025,{"v":9.94939674460149e-05,"d":"9.95E-05"},"MAPK14/PTGS2/MAPK1/STAT3/AKT1/PIK3R1/SHH/TP53",8]
["GO:0003014","renal system process","7/143","120/18670",{"v":3.86029141254638e-05,"d":"3.86E-05"},0.000220712706751239,0.000102734487488225,"REN/KCNQ1/AVPR2/AVPR1A/AKR1B1/SGK1/AGTR1",7]
["GO:0022612","gland morphogenesis","7/143","120/18670",{"v":3.86029141254638e-05,"d":"3.86E-05"},0.000220712706751239,0.000102734487488225,"AR/FGFR1/ESR1/VDR/SHH/TNF/GLI2",7]
["GO:0072089","stem cell proliferation","7/143","120/18670",{"v":3.86029141254638e-05,"d":"3.86E-05"},0.000220712706751239,0.000102734487488225,"FGFR1/SHH/VEGFA/FGF2/ACE/HIF1A/TP53",7]
["GO:0006633","fatty acid biosynthetic process","8/143","164/18670",{"v":3.88858801931e-05,"d":"3.89E-05"},0.00022201698592619,0.000103341586438496,"PTGS2/ALOX12/AVPR1A/SIRT1/CYP3A4/PRKAA2/ACACB/IL1B",8]
["GO:0009409","response to cold","5/143","50/18670",{"v":3.9459844782287e-05,"d":"3.95E-05"},0.000224976692505208,0.00010471923226137,"PPARG/FOS/FOXO1/EIF2AK3/ADRB2",5]
["GO:2000106","regulation of leukocyte apoptotic process","6/143","83/18670",{"v":4.22535288592041e-05,"d":"4.23E-05"},0.000240565801437494,0.000111975448453587,"IL2/SIRT1/HIF1A/TP53/CCR5/HCAR2",6]
["GO:0043281","regulation of cysteine-type endopeptidase activity involved in apoptotic process","9/143","215/18670",{"v":4.23422013524413e-05,"d":"4.23E-05"},0.000240732066116127,0.000112052839179287,"PTGS2/MMP9/AKT1/PPARG/ALOX12/TNF/VEGFA/SIRT1/EIF2AK3",9]
["GO:0043500","muscle adaptation","7/143","122/18670",{"v":4.29186320984122e-05,"d":"4.29E-05"},0.000243667072558727,0.00011341898790309,"MTOR/NOS3/PPARA/HMOX1/FOXO1/PARP2/IL1B",7]
["GO:0032800","receptor biosynthetic process","4/143","26/18670",{"v":4.3272323631902e-05,"d":"4.33E-05"},0.00024464576265634,0.000113874535873426,"PPARG/PPARA/TNF/HIF1A",4]
["GO:0060740","prostate gland epithelium morphogenesis","4/143","26/18670",{"v":4.3272323631902e-05,"d":"4.33E-05"},0.00024464576265634,0.000113874535873426,"AR/ESR1/SHH/GLI2",4]
["GO:1903959","regulation of anion transmembrane transport","4/143","26/18670",{"v":4.3272323631902e-05,"d":"4.33E-05"},0.00024464576265634,0.000113874535873426,"MTOR/AKT1/CFTR/AKT2",4]
["GO:0046889","positive regulation of lipid biosynthetic process","6/143","84/18670",{"v":4.52195375282415e-05,"d":"4.52E-05"},0.000254947633431886,0.000118669717038453,"PTGS2/MTOR/AKT1/AVPR1A/TNF/IL1B",6]
["GO:0042089","cytokine biosynthetic process","7/143","123/18670",{"v":4.52204547440944e-05,"d":"4.52E-05"},0.000254947633431886,0.000118669717038453,"TLR4/TLR9/STAT3/TNF/HMOX1/IL6/IL1B",7]
["GO:0043393","regulation of protein binding","9/143","217/18670",{"v":4.55042045432376e-05,"d":"4.55E-05"},0.000256190570223958,0.000119248263132121,"GSK3B/MAPK8/MMP9/MAPK3/AKT1/PPARA/ACE/PRMT7/ADRB2",9]
["GO:0016485","protein processing","11/143","328/18670",{"v":4.57617956575589e-05,"d":"4.58E-05"},0.00025728298447472,0.000119756745945951,"BACE2/REN/F2/CASP3/PLAT/SHH/SERPINE1/PCSK7/ACE/OGT/IL1B",11]
["GO:0008637","apoptotic mitochondrial changes","7/143","124/18670",{"v":4.76225753799782e-05,"d":"4.76E-05"},0.000265898186397451,0.000123766838374099,"GSK3B/MAPK8/MMP9/AKT1/HK2/TP53/ATP2A1",7]
["GO:0014013","regulation of gliogenesis","7/143","124/18670",{"v":4.76225753799782e-05,"d":"4.76E-05"},0.000265898186397451,0.000123766838374099,"F2/MTOR/PPARG/SHH/TNF/IL6/IL1B",7]
["GO:0019218","regulation of steroid metabolic process","7/143","124/18670",{"v":4.76225753799782e-05,"d":"4.76E-05"},0.000265898186397451,0.000123766838374099,"HMGCR/VDR/TNF/SIRT1/AGTR1/ACACB/IL1B",7]
["GO:0042107","cytokine metabolic process","7/143","124/18670",{"v":4.76225753799782e-05,"d":"4.76E-05"},0.000265898186397451,0.000123766838374099,"TLR4/TLR9/STAT3/TNF/HMOX1/IL6/IL1B",7]
["GO:0046717","acid secretion","7/143","124/18670",{"v":4.76225753799782e-05,"d":"4.76E-05"},0.000265898186397451,0.000123766838374099,"NOS2/KCNQ1/AVPR1A/SGK1/ACE/CASR/IL1B",7]
["GO:0038095","Fc-epsilon receptor signaling pathway","8/143","169/18670",{"v":4.81371121880692e-05,"d":"4.81E-05"},0.000268031678318163,0.000124759908516099,"MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/PIK3R1/IKBKB/FOS",8]
["GO:0051100","negative regulation of binding","8/143","169/18670",{"v":4.81371121880692e-05,"d":"4.81E-05"},0.000268031678318163,0.000124759908516099,"GSK3B/MAPK8/MAPK3/AKT1/PPARA/ACE/HMOX1/ADRB2",8]
["GO:1904705","regulation of vascular smooth muscle cell proliferation","6/143","85/18670",{"v":4.83500216755215e-05,"d":"4.84E-05"},0.000268478584008931,0.000124967928379443,"MMP9/PPARG/MMP2/TNF/FGF2/HMOX1",6]
["GO:1990874","vascular smooth muscle cell proliferation","6/143","85/18670",{"v":4.83500216755215e-05,"d":"4.84E-05"},0.000268478584008931,0.000124967928379443,"MMP9/PPARG/MMP2/TNF/FGF2/HMOX1",6]
["GO:0048762","mesenchymal cell differentiation","9/143","219/18670",{"v":4.88635754650905e-05,"d":"4.89E-05"},0.000270958566414639,0.000126122278417465,"GSK3B/MAPK1/FGFR1/MTOR/MAPK3/SHH/IL6/HIF1A/IL1B",9]
["GO:0045471","response to ethanol","7/143","125/18670",{"v":5.01283270302133e-05,"d":"5.01E-05"},0.00027697927518895,0.000128924719832593,"HMGCR/STAT3/CNR1/IL2/SETD7/RBP4/ICAM1",7]
["GO:0006735","NADH regeneration","4/143","27/18670",{"v":5.04967156841515e-05,"d":"5.05E-05"},0.00027697927518895,0.000128924719832593,"GCK/HK2/HK1/GAPDH",4]
["GO:0046885","regulation of hormone biosynthetic process","4/143","27/18670",{"v":5.04967156841515e-05,"d":"5.05E-05"},0.00027697927518895,0.000128924719832593,"VDR/TNF/HIF1A/IL1B",4]
["GO:0048143","astrocyte activation","4/143","27/18670",{"v":5.04967156841515e-05,"d":"5.05E-05"},0.00027697927518895,0.000128924719832593,"BACE2/TNF/IL6/IL1B",4]
["GO:0060259","regulation of feeding behavior","4/143","27/18670",{"v":5.04967156841515e-05,"d":"5.05E-05"},0.00027697927518895,0.000128924719832593,"MTOR/STAT3/CNR1/MC4R",4]
["GO:0061621","canonical glycolysis","4/143","27/18670",{"v":5.04967156841515e-05,"d":"5.05E-05"},{"v":0.00027697927518895,"d":"2.77E-04"},{"v":0.000128924719832593,"d":"1.29E-04"},"GCK/HK2/HK1/GAPDH",4]
["GO:0061718","glucose catabolic process to pyruvate","4/143","27/18670",{"v":5.04967156841515e-05,"d":"5.05E-05"},{"v":0.00027697927518895,"d":"2.77E-04"},{"v":0.000128924719832593,"d":"1.29E-04"},"GCK/HK2/HK1/GAPDH",4]
["GO:1902175","regulation of oxidative stress-induced intrinsic apoptotic signaling pathway","4/143","27/18670",{"v":5.04967156841515e-05,"d":"5.05E-05"},{"v":0.00027697927518895,"d":"2.77E-04"},{"v":0.000128924719832593,"d":"1.29E-04"},"AKT1/SIRT1/HIF1A/NFE2L2",4]
["GO:0046322","negative regulation of fatty acid oxidation","3/143","10/18670",{"v":5.07610452646765e-05,"d":"5.08E-05"},{"v":0.000277676636799203,"d":"2.78E-04"},{"v":0.000129249318668237,"d":"1.29E-04"},"AKT1/CNR1/ACACB",3]
["GO:0060513","prostatic bud formation","3/143","10/18670",{"v":5.07610452646765e-05,"d":"5.08E-05"},{"v":0.000277676636799203,"d":"2.78E-04"},{"v":0.000129249318668237,"d":"1.29E-04"},"AR/SHH/GLI2",3]
["GO:0001776","leukocyte homeostasis","6/143","86/18670",{"v":5.16516423250148e-05,"d":"5.17E-05"},{"v":0.000281407601792274,"d":"2.81E-04"},{"v":0.000130985959852343,"d":"1.31E-04"},"AKT1/CASP3/IL2/IL6/HIF1A/HCAR2",6]
["GO:0008625","extrinsic apoptotic signaling pathway via death domain receptors","6/143","86/18670",{"v":5.16516423250148e-05,"d":"5.17E-05"},{"v":0.000281407601792274,"d":"2.81E-04"},{"v":0.000130985959852343,"d":"1.31E-04"},"NOS3/PIK3R1/TNF/SERPINE1/HMOX1/ICAM1",6]
["GO:0090559","regulation of membrane permeability","6/143","86/18670",{"v":5.16516423250148e-05,"d":"5.17E-05"},{"v":0.000281407601792274,"d":"2.81E-04"},{"v":0.000130985959852343,"d":"1.31E-04"},"GSK3B/MAPK8/MTOR/STAT3/HK2/TP53",6]
["GO:0002697","regulation of immune effector process","13/143","458/18670",{"v":5.20960686000415e-05,"d":"5.21E-05"},{"v":0.000283447427006677,"d":"2.83E-04"},{"v":0.000131935431231005,"d":"1.32E-04"},"TLR4/MAPK14/TLR9/F2/MAPK3/HK1/IL2/TNF/HMOX1/IL6/PRKCZ/RBP4/IL1B",13]
["GO:0030195","negative regulation of blood coagulation","5/143","53/18670",{"v":5.24694557068687e-05,"d":"5.25E-05"},{"v":0.000285095780807254,"d":"2.85E-04"},{"v":0.000132702685574419,"d":"1.33E-04"},"F2/NOS3/ALOX12/PLAT/SERPINE1",5]
["GO:0002690","positive regulation of leukocyte chemotaxis","6/143","87/18670",{"v":5.51312249650819e-05,"d":"5.51E-05"},{"v":0.000299157102759587,"d":"2.99E-04"},{"v":0.000139247767302803,"d":"1.39E-04"},"MAPK14/MAPK3/VEGFA/SERPINE1/IL6/PGF",6]
["GO:0060485","mesenchyme development","10/143","278/18670",{"v":5.71786234533839e-05,"d":"5.72E-05"},{"v":0.000309851496304281,"d":"3.10E-04"},{"v":0.000144225654874314,"d":"1.44E-04"},"GSK3B/MAPK1/FGFR1/MTOR/MAPK3/NOS3/SHH/IL6/HIF1A/IL1B",10]
["GO:0006636","unsaturated fatty acid biosynthetic process","5/143","54/18670",{"v":5.74695663217502e-05,"d":"5.75E-05"},{"v":0.000310596534673491,"d":"3.11E-04"},{"v":0.000144572445669219,"d":"1.45E-04"},"PTGS2/ALOX12/AVPR1A/SIRT1/IL1B",5]
["GO:1900047","negative regulation of hemostasis","5/143","54/18670",{"v":5.74695663217502e-05,"d":"5.75E-05"},{"v":0.000310596534673491,"d":"3.11E-04"},{"v":0.000144572445669219,"d":"1.45E-04"},"F2/NOS3/ALOX12/PLAT/SERPINE1",5]
["GO:0001516","prostaglandin biosynthetic process","4/143","28/18670",{"v":5.85635595049783e-05,"d":"5.86E-05"},{"v":0.000313578424439355,"d":"3.14E-04"},{"v":0.000145960417034129,"d":"1.46E-04"},"PTGS2/AVPR1A/SIRT1/IL1B",4]
["GO:0008209","androgen metabolic process","4/143","28/18670",{"v":5.85635595049783e-05,"d":"5.86E-05"},{"v":0.000313578424439355,"d":"3.14E-04"},{"v":0.000145960417034129,"d":"1.46E-04"},"CYP19A1/ESR1/SHH/CYP3A4",4]
["GO:0032770","positive regulation of monooxygenase activity","4/143","28/18670",{"v":5.85635595049783e-05,"d":"5.86E-05"},{"v":0.000313578424439355,"d":"3.14E-04"},{"v":0.000145960417034129,"d":"1.46E-04"},"AKT1/TNF/HIF1A/IL1B",4]
["GO:0046457","prostanoid biosynthetic process","4/143","28/18670",{"v":5.85635595049783e-05,"d":"5.86E-05"},{"v":0.000313578424439355,"d":"3.14E-04"},{"v":0.000145960417034129,"d":"1.46E-04"},"PTGS2/AVPR1A/SIRT1/IL1B",4]
["GO:0060512","prostate gland morphogenesis","4/143","28/18670",{"v":5.85635595049783e-05,"d":"5.86E-05"},{"v":0.000313578424439355,"d":"3.14E-04"},{"v":0.000145960417034129,"d":"1.46E-04"},"AR/ESR1/SHH/GLI2",4]
["GO:0061615","glycolytic process through fructose-6-phosphate","4/143","28/18670",{"v":5.85635595049783e-05,"d":"5.86E-05"},{"v":0.000313578424439355,"d":"3.14E-04"},{"v":0.000145960417034129,"d":"1.46E-04"},"GCK/HK2/HK1/GAPDH",4]
["GO:0061620","glycolytic process through glucose-6-phosphate","4/143","28/18670",{"v":5.85635595049783e-05,"d":"5.86E-05"},{"v":0.000313578424439355,"d":"3.14E-04"},{"v":0.000145960417034129,"d":"1.46E-04"},"GCK/HK2/HK1/GAPDH",4]
["GO:1900407","regulation of cellular response to oxidative stress","6/143","88/18670",{"v":5.87957604636592e-05,"d":"5.88E-05"},{"v":0.000313991079626507,"d":"3.14E-04"},{"v":0.000146152494417372,"d":"1.46E-04"},"TLR4/AKT1/TNF/SIRT1/HIF1A/NFE2L2",6]
["GO:2000177","regulation of neural precursor cell proliferation","6/143","88/18670",{"v":5.87957604636592e-05,"d":"5.88E-05"},{"v":0.000313991079626507,"d":"3.14E-04"},{"v":0.000146152494417372,"d":"1.46E-04"},"SHH/VEGFA/FOXO1/HIF1A/GLI2/TP53",6]
["GO:0060047","heart contraction","10/143","280/18670",{"v":6.07092797108195e-05,"d":"6.07E-05"},{"v":0.000323738160891336,"d":"3.24E-04"},{"v":0.000150689439358095,"d":"1.51E-04"},"PIK3CA/PIK3CG/MTOR/KCNQ1/NOS3/AVPR1A/IL2/ACE/KCNJ11/ATP2A1",10]
["GO:0003012","muscle system process","13/143","465/18670",{"v":6.07808800092429e-05,"d":"6.08E-05"},{"v":0.000323738160891336,"d":"3.24E-04"},{"v":0.000150689439358095,"d":"1.51E-04"},"PTGS2/PIK3CA/PIK3CG/MTOR/KCNQ1/NOS3/PPARA/HMOX1/FOXO1/ADRB2/PARP2/ATP2A1/IL1B",13]
["GO:0046427","positive regulation of JAK-STAT cascade","6/143","89/18670",{"v":6.26524059282235e-05,"d":"6.27E-05"},{"v":0.000332898485216811,"d":"3.33E-04"},{"v":0.000154953268290538,"d":"1.55E-04"},"F2/STAT3/IL2/AKR1B1/TNF/IL6",6]
["GO:0042304","regulation of fatty acid biosynthetic process","5/143","55/18670",{"v":6.28296548185878e-05,"d":"6.28E-05"},{"v":0.000332898485216811,"d":"3.33E-04"},{"v":0.000154953268290538,"d":"1.55E-04"},"PTGS2/AVPR1A/SIRT1/PRKAA2/IL1B",5]
["GO:0042306","regulation of protein import into nucleus","5/143","55/18670",{"v":6.28296548185878e-05,"d":"6.28E-05"},{"v":0.000332898485216811,"d":"3.33E-04"},{"v":0.000154953268290538,"d":"1.55E-04"},"MAPK14/PTGS2/MAPK1/PIK3R1/SHH",5]
["GO:0046456","icosanoid biosynthetic process","5/143","55/18670",{"v":6.28296548185878e-05,"d":"6.28E-05"},{"v":0.000332898485216811,"d":"3.33E-04"},{"v":0.000154953268290538,"d":"1.55E-04"},"PTGS2/ALOX12/AVPR1A/SIRT1/IL1B",5]
["GO:0001894","tissue homeostasis","9/143","227/18670",{"v":6.44765091663397e-05,"d":"6.45E-05"},{"v":0.000341177658961233,"d":"3.41E-04"},{"v":0.000158806950681456,"d":"1.59E-04"},"TLR4/TLR9/NOS3/AKR1B1/VEGFA/IL6/ADRB2/RBP4/MC4R",9]
["GO:0032409","regulation of transporter activity","10/143","283/18670",{"v":6.63528241871263e-05,"d":"6.64E-05"},{"v":0.000350647822858338,"d":"3.51E-04"},{"v":0.00016321499971823,"d":"1.63E-04"},"MMP9/TLR9/MTNR1B/PPARG/PON1/CFTR/SGK1/KCNJ11/ADRB2/ATP2A1",10]
["GO:0031058","positive regulation of histone modification","6/143","90/18670",{"v":6.67084855105477e-05,"d":"6.67E-05"},{"v":0.000351609309045179,"d":"3.52E-04"},{"v":0.000163662539835362,"d":"1.64E-04"},"MAPK3/VEGFA/SIRT1/OGT/TP53/IL1B",6]
["GO:0071674","mononuclear cell migration","6/143","90/18670",{"v":6.67084855105477e-05,"d":"6.67E-05"},{"v":0.000351609309045179,"d":"3.52E-04"},{"v":0.000163662539835362,"d":"1.64E-04"},"MAPK14/FLT1/MAPK3/TNF/SERPINE1/IL6",6]
["GO:0031295","T cell costimulation","5/143","56/18670",{"v":6.85672894834254e-05,"d":"6.86E-05"},{"v":0.000360936785213142,"d":"3.61E-04"},{"v":0.000168004172439027,"d":"1.68E-04"},"PIK3CA/YES1/AKT1/PIK3R1/DPP4",5]
["GO:0043619","regulation of transcription from RNA polymerase II promoter in response to oxidative stress","3/143","11/18670",{"v":6.94047626443863e-05,"d":"6.94E-05"},{"v":0.000363454694934639,"d":"3.63E-04"},{"v":0.000169176176391981,"d":"1.69E-04"},"HMOX1/HIF1A/NFE2L2",3]
["GO:0046886","positive regulation of hormone biosynthetic process","3/143","11/18670",{"v":6.94047626443863e-05,"d":"6.94E-05"},{"v":0.000363454694934639,"d":"3.63E-04"},{"v":0.000169176176391981,"d":"1.69E-04"},"TNF/HIF1A/IL1B",3]
["GO:0051024","positive regulation of immunoglobulin secretion","3/143","11/18670",{"v":6.94047626443863e-05,"d":"6.94E-05"},{"v":0.000363454694934639,"d":"3.63E-04"},{"v":0.000169176176391981,"d":"1.69E-04"},"IL2/IL6/RBP4",3]
["GO:0060439","trachea morphogenesis","3/143","11/18670",{"v":6.94047626443863e-05,"d":"6.94E-05"},{"v":0.000363454694934639,"d":"3.63E-04"},{"v":0.000169176176391981,"d":"1.69E-04"},"MAPK1/MAPK3/SHH",3]
["GO:0050769","positive regulation of neurogenesis","13/143","474/18670",{"v":7.37796877537181e-05,"d":"7.38E-05"},{"v":0.000385865860500066,"d":"3.86E-04"},{"v":0.000179607835004971,"d":"1.80E-04"},"FGFR1/MTOR/CNR1/PPARG/IL2/SHH/TNF/VEGFA/IL6/HIF1A/GLI2/NFE2L2/IL1B",13]
["GO:0019320","hexose catabolic process","5/143","57/18670",{"v":7.47004710132316e-05,"d":"7.47E-05"},{"v":0.000388672887739796,"d":"3.89E-04"},{"v":0.000180914413629664,"d":"1.81E-04"},"GCK/HK2/HK1/GAPDH/TP53",5]
["GO:0031294","lymphocyte costimulation","5/143","57/18670",{"v":7.47004710132316e-05,"d":"7.47E-05"},{"v":0.000388672887739796,"d":"3.89E-04"},{"v":0.000180914413629664,"d":"1.81E-04"},"PIK3CA/YES1/AKT1/PIK3R1/DPP4",5]
["GO:0050819","negative regulation of coagulation","5/143","57/18670",{"v":7.47004710132316e-05,"d":"7.47E-05"},{"v":0.000388672887739796,"d":"3.89E-04"},{"v":0.000180914413629664,"d":"1.81E-04"},"F2/NOS3/ALOX12/PLAT/SERPINE1",5]
["GO:0060043","regulation of cardiac muscle cell proliferation","5/143","57/18670",{"v":7.47004710132316e-05,"d":"7.47E-05"},{"v":0.000388672887739796,"d":"3.89E-04"},{"v":0.000180914413629664,"d":"1.81E-04"},"MAPK14/MAPK1/FGFR1/FGF2/RBP4",5]
["GO:1905330","regulation of morphogenesis of an epithelium","8/143","180/18670",{"v":7.50740515971508e-05,"d":"7.51E-05"},{"v":0.000390115225757723,"d":"3.90E-04"},{"v":0.000181585774419161,"d":"1.82E-04"},"AR/FGFR1/MTOR/ESR1/ALOX12/SHH/TNF/VEGFA",8]
["GO:1904894","positive regulation of STAT cascade","6/143","92/18670",{"v":7.54490832994522e-05,"d":"7.54E-05"},{"v":0.000391561396405362,"d":"3.92E-04"},{"v":0.000182258919171416,"d":"1.82E-04"},"F2/STAT3/IL2/AKR1B1/TNF/IL6",6]
["GO:0010743","regulation of macrophage derived foam cell differentiation","4/143","30/18670",{"v":7.74586847494702e-05,"d":"7.75E-05"},{"v":0.00040147599982824,"d":"4.01E-04"},{"v":0.000186873840153045,"d":"1.87E-04"},"PPARG/PPARA/AGTR1/CETP",4]
["GO:0002285","lymphocyte activation involved in immune response","8/143","181/18670",{"v":7.80442668689822e-05,"d":"7.80E-05"},{"v":0.000403477895639387,"d":"4.03E-04"},{"v":0.000187805656645127,"d":"1.88E-04"},"TLR4/MTOR/STAT3/IL2/IL6/PRKCZ/TP53/ICAM1",8]
["GO:0022408","negative regulation of cell-cell adhesion","8/143","181/18670",{"v":7.80442668689822e-05,"d":"7.80E-05"},0.000403477895639387,{"v":0.000187805656645127,"d":"1.88E-04"},"AKT1/CASP3/ALOX12/PPARA/IL2/SHH/VEGFA/PTPN22",8]
["GO:0048738","cardiac muscle tissue development","9/143","233/18670",{"v":7.87760179695196e-05,"d":"7.88E-05"},0.000406741480536499,{"v":0.000189324747805371,"d":"1.89E-04"},"MAPK14/MAPK1/FGFR1/MTOR/PPARA/VEGFA/FGF2/PARP2/RBP4",9]
["GO:0007162","negative regulation of cell adhesion","10/143","289/18670",{"v":7.89893029601583e-05,"d":"7.90E-05"},0.000407323182653148,{"v":0.000189595510960353,"d":"1.90E-04"},"AKT1/PIK3R1/CASP3/ALOX12/PPARA/IL2/SHH/VEGFA/SERPINE1/PTPN22",10]
["GO:0006476","protein deacetylation","6/143","93/18670",{"v":8.01490915019101e-05,"d":"8.01E-05"},0.00041277801832027,{"v":0.000192134557102476,"d":"1.92E-04"},"MAPK8/HDAC11/VEGFA/SIRT1/TP53/PRKAA2",6]
["GO:0042093","T-helper cell differentiation","5/143","58/18670",{"v":8.1247629815307e-05,"d":"8.12E-05"},0.000416495194402412,{"v":0.000193864780003203,"d":"1.94E-04"},"MTOR/STAT3/IL2/IL6/PRKCZ",5]
["GO:0061900","glial cell activation","5/143","58/18670",{"v":8.1247629815307e-05,"d":"8.12E-05"},0.000416495194402412,{"v":0.000193864780003203,"d":"1.94E-04"},"BACE2/NAMPT/TNF/IL6/IL1B",5]
["GO:1904589","regulation of protein import","5/143","58/18670",{"v":8.1247629815307e-05,"d":"8.12E-05"},0.000416495194402412,{"v":0.000193864780003203,"d":"1.94E-04"},"MAPK14/PTGS2/MAPK1/PIK3R1/SHH",5]
["GO:0003015","heart process","10/143","290/18670",{"v":8.12824119510635e-05,"d":"8.13E-05"},0.000416495194402412,0.000193864780003203,"PIK3CA/PIK3CG/MTOR/KCNQ1/NOS3/AVPR1A/IL2/ACE/KCNJ11/ATP2A1",10]
["GO:0006469","negative regulation of protein kinase activity","9/143","235/18670",{"v":8.40985957886198e-05,"d":"8.41E-05"},0.000430210791724111,0.000200248938315519,"IGF1R/HMGCR/AKT1/PTPN1/CASP3/FABP4/SIRT1/PTPN22/IL1B",9]
["GO:0002040","sprouting angiogenesis","8/143","183/18670",{"v":8.4277954011171e-05,"d":"8.43E-05"},0.000430210791724111,0.000200248938315519,"PTGS2/FLT1/AKT1/VEGFA/FGF2/HMOX1/PGF/AGTR1",8]
["GO:0043123","positive regulation of I-kappaB kinase/NF-kappaB signaling","8/143","183/18670",{"v":8.4277954011171e-05,"d":"8.43E-05"},0.000430210791724111,0.000200248938315519,"TLR4/TLR9/PRKCB/AKT1/IKBKB/TNF/HMOX1/IL1B",8]
["GO:0090287","regulation of cellular response to growth factor stimulus","10/143","292/18670",{"v":8.60387075949345e-05,"d":"8.60E-05"},0.000438645703204402,0.000204175111487383,"FLT1/FGFR1/PRKCB/PTPN1/VEGFA/FGF2/SIRT1/HIF1A/TP53/IL1B",10]
["GO:0043409","negative regulation of MAPK cascade","8/143","184/18670",{"v":8.75463932140173e-05,"d":"8.75E-05"},0.00044577081727087,0.000207491617150733,"TLR4/IGF1R/HMGCR/AKT1/PTPN1/FOXO1/PTPN22/IL1B",8]
["GO:0001885","endothelial cell development","5/143","59/18670",{"v":8.82276230884178e-05,"d":"8.82E-05"},0.000448675148570245,0.000208843487606808,"IKBKB/TNF/VEGFA/ICAM1/IL1B",5]
["GO:1902895","positive regulation of pri-miRNA transcription by RNA polymerase II","4/143","31/18670",{"v":8.84071242395523e-05,"d":"8.84E-05"},0.00044895335908767,0.000208972985429304,"STAT3/FOS/HIF1A/TP53",4]
["GO:0051146","striated muscle cell differentiation","10/143","293/18670",{"v":8.8504145393271e-05,"d":"8.85E-05"},0.00044895335908767,0.000208972985429304,"MAPK14/MTOR/AKT1/CASP3/AVPR1A/PPARA/SHH/VEGFA/PARP2/CYP26B1",10]
["GO:0034248","regulation of cellular amide metabolic process","13/143","483/18670",{"v":8.91288636011032e-05,"d":"8.91E-05"},0.000450992049821582,0.000209921928744704,"MAPK1/MTOR/MAPK3/STAT3/AKT1/CASP3/TNF/AKT2/GAPDH/IL6/EIF2AK3/FTO/NFE2L2",13]
["GO:0034765","regulation of ion transmembrane transport","13/143","483/18670",{"v":8.91288636011032e-05,"d":"8.91E-05"},0.000450992049821582,0.000209921928744704,"MMP9/TLR9/PIK3CG/F2/MTOR/MTNR1B/KCNQ1/AKT1/CFTR/AKT2/KCNJ11/ADRB2/ATP2A1",13]
["GO:0031644","regulation of neurological system process","7/143","137/18670",{"v":8.9596581705249e-05,"d":"8.96E-05"},0.00045222813309582,0.000210497284751799,"MTOR/MTNR1B/NOS3/AVPR1A/PRKCZ/EIF2AK3/ADRB2",7]
["GO:0034605","cellular response to heat","7/143","137/18670",{"v":8.9596581705249e-05,"d":"8.96E-05"},0.00045222813309582,0.000210497284751799,"GSK3B/PTGS2/MAPK1/MTOR/MAPK3/SIRT1/HMOX1",7]
["GO:0050810","regulation of steroid biosynthetic process","6/143","95/18670",{"v":9.02485234241666e-05,"d":"9.02E-05"},0.000454951460549223,0.000211764903885768,"HMGCR/VDR/TNF/SIRT1/ACACB/IL1B",6]
["GO:1902275","regulation of chromatin organization","8/143","185/18670",{"v":9.09192799236129e-05,"d":"9.09E-05"},0.000457762742699981,0.000213073463031248,"MAPK8/MAPK3/VEGFA/SIRT1/SETD7/OGT/TP53/IL1B",8]
["GO:0006983","ER overload response","3/143","12/18670",{"v":9.20205573678339e-05,"d":"9.20E-05"},0.00046044402499999,0.000214321511532656,"GSK3B/EIF2AK3/TP53",3]
["GO:0042659","regulation of cell fate specification","3/143","12/18670",{"v":9.20205573678339e-05,"d":"9.20E-05"},0.00046044402499999,0.000214321511532656,"AR/FGFR1/FGF2",3]
["GO:0045080","positive regulation of chemokine biosynthetic process","3/143","12/18670",{"v":9.20205573678339e-05,"d":"9.20E-05"},0.00046044402499999,0.000214321511532656,"TNF/HMOX1/IL1B",3]
["GO:0045416","positive regulation of interleukin-8 biosynthetic process","3/143","12/18670",{"v":9.20205573678339e-05,"d":"9.20E-05"},0.00046044402499999,0.000214321511532656,"TLR4/TLR9/TNF",3]
["GO:1900402","regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter","3/143","12/18670",{"v":9.20205573678339e-05,"d":"9.20E-05"},0.00046044402499999,0.000214321511532656,"PPARA/FOXO1/TP53",3]
["GO:0051048","negative regulation of secretion","9/143","238/18670",{"v":9.26474749949441e-05,"d":"9.26E-05"},0.000463008615777202,0.000215515243977843,"HMGCR/MTNR1B/CNR1/AVPR2/TNF/HMOX1/KCNJ11/PTPN22/IL1B",9]
["GO:2000116","regulation of cysteine-type endopeptidase activity","9/143","239/18670",{"v":9.56544336675128e-05,"d":"9.57E-05"},0.000476321920676224,0.000221712148432089,"PTGS2/MMP9/AKT1/PPARG/ALOX12/TNF/VEGFA/SIRT1/EIF2AK3",9]
["GO:0002294","CD4-positive, alpha-beta T cell differentiation involved in immune response","5/143","60/18670",{"v":9.56597316931202e-05,"d":"9.57E-05"},0.000476321920676224,0.000221712148432089,"MTOR/STAT3/IL2/IL6/PRKCZ",5]
["GO:0032755","positive regulation of interleukin-6 production","6/143","96/18670",{"v":9.5664456894706e-05,"d":"9.57E-05"},0.000476321920676224,0.000221712148432089,"TLR4/TLR9/STAT3/TNF/IL6/IL1B",6]
["GO:0051480","regulation of cytosolic calcium ion concentration","11/143","357/18670",{"v":9.76070831157493e-05,"d":"9.76E-05"},0.000485397386305348,0.000225936478439404,"PIK3CG/MCHR1/F2/MTNR1B/CNR1/ESR1/AVPR1A/IL2/FGF2/AGTR1/CCR5",11]
["GO:0033135","regulation of peptidyl-serine phosphorylation","7/143","139/18670",{"v":9.81364151974759e-05,"d":"9.81E-05"},0.000487430930944028,0.000226883026417155,"BRAF/PTGS2/PIK3CA/AKT1/TNF/VEGFA/IL6",7]
["GO:0043062","extracellular structure organization","12/143","422/18670",0.00010038350563337,0.000496427221661004,0.00023107050311348,"MMP9/MMP2/TNF/TTR/FGF2/SERPINE1/DPP4/IL6/AGTR1/ICAM1/CTRB1/CETP",12]
["GO:0042311","vasodilation","4/143","32/18670",0.000100438215054437,0.000496427221661004,0.00023107050311348,"ADRB3/NOS3/ADRB2/CASR",4]
["GO:0045922","negative regulation of fatty acid metabolic process","4/143","32/18670",0.000100438215054437,0.000496427221661004,0.00023107050311348,"AKT1/CNR1/SIRT1/ACACB",4]
["GO:0055094","response to lipoprotein particle","4/143","32/18670",0.000100438215054437,0.000496427221661004,0.00023107050311348,"TLR4/AKT1/PPARG/CASR",4]
["GO:0030316","osteoclast differentiation","6/143","97/18670",0.000101335826822212,0.000499035799241259,0.000232284709965117,"TLR4/MAPK14/MTOR/PIK3R1/TNF/FOS",6]
["GO:0120162","positive regulation of cold-induced thermogenesis","6/143","97/18670",0.000101335826822212,0.000499035799241259,0.000232284709965117,"IGF1R/ADRB3/FABP4/VEGFA/OGT/ADRB2",6]
["GO:1902882","regulation of response to oxidative stress","6/143","97/18670",0.000101335826822212,0.000499035799241259,0.000232284709965117,"TLR4/AKT1/TNF/SIRT1/HIF1A/NFE2L2",6]
["GO:0038093","Fc receptor signaling pathway","9/143","241/18670",0.000101914656955461,0.000501276465802802,0.000233327666368581,"MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/YES1/PIK3R1/IKBKB/FOS",9]
["GO:0046330","positive regulation of JNK cascade","7/143","140/18670",0.000102648341264002,0.000504272433782378,0.000234722190677776,"TLR4/TLR9/PTPN1/TNF/HRAS/MAP3K9/IL1B",7]
["GO:0002287","alpha-beta T cell activation involved in immune response","5/143","61/18670",0.000103563656818594,0.000506311211113128,0.000235671174301149,"MTOR/STAT3/IL2/IL6/PRKCZ",5]
["GO:0002293","alpha-beta T cell differentiation involved in immune response","5/143","61/18670",0.000103563656818594,0.000506311211113128,0.000235671174301149,"MTOR/STAT3/IL2/IL6/PRKCZ",5]
["GO:0007405","neuroblast proliferation","5/143","61/18670",0.000103563656818594,0.000506311211113128,0.000235671174301149,"FGFR1/SHH/VEGFA/HIF1A/TP53",5]
["GO:0045123","cellular extravasation","5/143","61/18670",0.000103563656818594,0.000506311211113128,0.000235671174301149,"PIK3CG/SELP/TNF/ICAM1/SELL",5]
["GO:0052548","regulation of endopeptidase activity","12/143","425/18670",0.000107297770371357,0.000523448811595975,0.000243648162252131,"PTGS2/MMP9/STAT3/AKT1/PPARG/ALOX12/TNF/VEGFA/SERPINE1/SIRT1/GAPDH/EIF2AK3",12]
["GO:0009411","response to UV","7/143","141/18670",0.000107327696053523,0.000523448811595975,0.000243648162252131,"PTGS2/MAPK8/AKT1/PIK3R1/CASP3/SIRT1/TP53",7]
["GO:0060759","regulation of response to cytokine stimulus","8/143","190/18670",0.000109442713251442,0.000533121664550946,0.000248150556362126,"TLR4/IKBKB/PTPN1/PPARG/TNF/AGPAT2/IL6/HIF1A",8]
["GO:0032922","circadian regulation of gene expression","5/143","62/18670",0.000111959516453152,0.000544072175993226,0.000253247658370053,"NAMPT/PPARA/SIRT1/OGT/NR0B2",5]
["GO:0070059","intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress","5/143","62/18670",0.000111959516453152,0.000544072175993226,0.000253247658370053,"PTPN1/SIRT1/EIF2AK3/TP53/ATP2A1",5]
["GO:0045861","negative regulation of proteolysis","11/143","363/18670",0.000113060909588361,0.000546864550235987,0.000254547416507806,"PTGS2/MMP9/F2/AKT1/PLAT/SHH/VEGFA/SERPINE1/GAPDH/OGT/TP53",11]
["GO:0071478","cellular response to radiation","8/143","191/18670",0.000113498282165496,0.000546864550235987,0.000254547416507806,"MAPK14/PTGS2/NAMPT/PIK3R1/HRAS/AKT2/SIRT1/TP53",8]
["GO:0016486","peptide hormone processing","4/143","33/18670",0.000113614892971459,0.000546864550235987,0.000254547416507806,"BACE2/REN/PCSK7/ACE",4]
["GO:0033028","myeloid cell apoptotic process","4/143","33/18670",0.000113614892971459,0.000546864550235987,0.000254547416507806,"SIRT1/IL6/CCR5/HCAR2",4]
["GO:0036003","positive regulation of transcription from RNA polymerase II promoter in response to stress","4/143","33/18670",0.000113614892971459,0.000546864550235987,0.000254547416507806,"VEGFA/HIF1A/TP53/NFE2L2",4]
["GO:0051194","positive regulation of cofactor metabolic process","4/143","33/18670",0.000113614892971459,0.000546864550235987,0.000254547416507806,"INSR/HIF1A/PRKAA2/NFE2L2",4]
["GO:0060603","mammary gland duct morphogenesis","4/143","33/18670",0.000113614892971459,0.000546864550235987,0.000254547416507806,"AR/ESR1/VDR/GLI2",4]
["GO:1902692","regulation of neuroblast proliferation","4/143","33/18670",{"v":0.000113614892971459,"d":"1.14E-04"},{"v":0.000546864550235987,"d":"5.47E-04"},{"v":0.000254547416507806,"d":"2.55E-04"},"SHH/VEGFA/HIF1A/TP53",4]
["GO:0032102","negative regulation of response to external stimulus","11/143","365/18670",{"v":0.000118655912832957,"d":"1.19E-04"},{"v":0.000567177125229229,"d":"5.67E-04"},{"v":0.000264002250405742,"d":"2.64E-04"},"F2/HMGCR/CYP19A1/NOS3/PPARG/ALOX12/PPARA/IL2/PLAT/FGF2/SERPINE1",11]
["GO:0003084","positive regulation of systemic arterial blood pressure","3/143","13/18670",{"v":0.00011895587433785,"d":"1.19E-04"},{"v":0.000567177125229229,"d":"5.67E-04"},{"v":0.000264002250405742,"d":"2.64E-04"},"AVPR2/AVPR1A/ACE",3]
["GO:0010745","negative regulation of macrophage derived foam cell differentiation","3/143","13/18670",{"v":0.00011895587433785,"d":"1.19E-04"},{"v":0.000567177125229229,"d":"5.67E-04"},{"v":0.000264002250405742,"d":"2.64E-04"},"PPARG/PPARA/CETP",3]
["GO:0014745","negative regulation of muscle adaptation","3/143","13/18670",{"v":0.00011895587433785,"d":"1.19E-04"},{"v":0.000567177125229229,"d":"5.67E-04"},{"v":0.000264002250405742,"d":"2.64E-04"},"MTOR/NOS3/FOXO1",3]
["GO:0030656","regulation of vitamin metabolic process","3/143","13/18670",{"v":0.00011895587433785,"d":"1.19E-04"},{"v":0.000567177125229229,"d":"5.67E-04"},{"v":0.000264002250405742,"d":"2.64E-04"},"VDR/TNF/IL1B",3]
["GO:0050872","white fat cell differentiation","3/143","13/18670",{"v":0.00011895587433785,"d":"1.19E-04"},{"v":0.000567177125229229,"d":"5.67E-04"},{"v":0.000264002250405742,"d":"2.64E-04"},"PPARG/FABP4/SIRT1",3]
["GO:0060601","lateral sprouting from an epithelium","3/143","13/18670",{"v":0.00011895587433785,"d":"1.19E-04"},{"v":0.000567177125229229,"d":"5.67E-04"},{"v":0.000264002250405742,"d":"2.64E-04"},"AR/SHH/GLI2",3]
["GO:1903960","negative regulation of anion transmembrane transport","3/143","13/18670",{"v":0.00011895587433785,"d":"1.19E-04"},{"v":0.000567177125229229,"d":"5.67E-04"},{"v":0.000264002250405742,"d":"2.64E-04"},"MTOR/AKT1/AKT2",3]
["GO:0030301","cholesterol transport","6/143","100/18670",{"v":0.000119970243474763,"d":"1.20E-04"},{"v":0.000571340641865693,"d":"5.71E-04"},{"v":0.00026594023011743,"d":"2.66E-04"},"PPARG/PON1/SHH/CFTR/SIRT1/CETP",6]
["GO:0002637","regulation of immunoglobulin production","5/143","63/18670",{"v":0.000120867841665442,"d":"1.21E-04"},{"v":0.000573590882839047,"d":"5.74E-04"},{"v":0.000266987643093898,"d":"2.67E-04"},"TLR9/IL2/TNF/IL6/RBP4",5]
["GO:0032371","regulation of sterol transport","5/143","63/18670",{"v":0.000120867841665442,"d":"1.21E-04"},{"v":0.000573590882839047,"d":"5.74E-04"},{"v":0.000266987643093898,"d":"2.67E-04"},"PPARG/PON1/SHH/SIRT1/CETP",5]
["GO:0032374","regulation of cholesterol transport","5/143","63/18670",{"v":0.000120867841665442,"d":"1.21E-04"},{"v":0.000573590882839047,"d":"5.74E-04"},{"v":0.000266987643093898,"d":"2.67E-04"},"PPARG/PON1/SHH/SIRT1/CETP",5]
["GO:0046632","alpha-beta T cell differentiation","6/143","101/18670",{"v":0.00012675190743199,"d":"1.27E-04"},{"v":0.000600809978085124,"d":"6.01E-04"},{"v":0.000279657234442577,"d":"2.80E-04"},"MTOR/STAT3/IL2/SHH/IL6/PRKCZ",6]
["GO:0007612","learning","7/143","145/18670",{"v":0.000127814062615539,"d":"1.28E-04"},{"v":0.000603199764344201,"d":"6.03E-04"},{"v":0.000280769601148357,"d":"2.81E-04"},"PTGS2/HMGCR/MTOR/INSR/HRH1/FOS/HIF1A",7]
["GO:0071901","negative regulation of protein serine/threonine kinase activity","7/143","145/18670",{"v":0.000127814062615539,"d":"1.28E-04"},{"v":0.000603199764344201,"d":"6.03E-04"},{"v":0.000280769601148357,"d":"2.81E-04"},"HMGCR/AKT1/PTPN1/CASP3/SIRT1/PTPN22/IL1B",7]
["GO:0032148","activation of protein kinase B activity","4/143","34/18670",{"v":0.000128001135763752,"d":"1.28E-04"},{"v":0.000603199764344201,"d":"6.03E-04"},{"v":0.000280769601148357,"d":"2.81E-04"},"MTOR/INSR/AKT1/PRKCZ",4]
["GO:0043368","positive T cell selection","4/143","34/18670",{"v":0.000128001135763752,"d":"1.28E-04"},{"v":0.000603199764344201,"d":"6.03E-04"},{"v":0.000280769601148357,"d":"2.81E-04"},"MTOR/STAT3/SHH/IL6",4]
["GO:0071402","cellular response to lipoprotein particle stimulus","4/143","34/18670",{"v":0.000128001135763752,"d":"1.28E-04"},{"v":0.000603199764344201,"d":"6.03E-04"},{"v":0.000280769601148357,"d":"2.81E-04"},"TLR4/AKT1/PPARG/CASR",4]
["GO:0045670","regulation of osteoclast differentiation","5/143","64/18670",{"v":0.000130309572703227,"d":"1.30E-04"},{"v":0.000612651742511804,"d":"6.13E-04"},{"v":0.000285169185327681,"d":"2.85E-04"},"TLR4/MTOR/PIK3R1/TNF/FOS",5]
["GO:1903672","positive regulation of sprouting angiogenesis","5/143","64/18670",{"v":0.000130309572703227,"d":"1.30E-04"},{"v":0.000612651742511804,"d":"6.13E-04"},{"v":0.000285169185327681,"d":"2.85E-04"},"PTGS2/VEGFA/FGF2/HMOX1/AGTR1",5]
["GO:0035264","multicellular organism growth","7/143","146/18670",{"v":0.000133402289716572,"d":"1.33E-04"},{"v":0.000626464580942787,"d":"6.26E-04"},{"v":0.000291598606170061,"d":"2.92E-04"},"AR/PIK3CA/MTOR/STAT3/ADRB2/TP53/FTO",7]
["GO:0001823","mesonephros development","6/143","102/18670",{"v":0.0001338341427413,"d":"1.34E-04"},{"v":0.000627764321919792,"d":"6.28E-04"},{"v":0.000292203592738826,"d":"2.92E-04"},"FGFR1/REN/SHH/VEGFA/FGF2/PGF",6]
["GO:0045637","regulation of myeloid cell differentiation","9/143","251/18670",{"v":0.000138616546006395,"d":"1.39E-04"},{"v":0.0006494441877707,"d":"6.49E-04"},{"v":0.000302294855447668,"d":"3.02E-04"},"TLR4/MAPK14/PRKCB/MTOR/STAT3/PIK3R1/TNF/FOS/HIF1A",9]
["GO:0010952","positive regulation of peptidase activity","8/143","197/18670",{"v":0.000140529282739588,"d":"1.41E-04"},{"v":0.000657644550901564,"d":"6.58E-04"},{"v":0.000306111854096578,"d":"3.06E-04"},"MAPK14/MAPK3/STAT3/PPARG/ALOX12/TNF/SIRT1/EIF2AK3",8]
["GO:0034766","negative regulation of ion transmembrane transport","6/143","103/18670",{"v":0.000141226493430301,"d":"1.41E-04"},{"v":0.000658623093785553,"d":"6.59E-04"},{"v":0.000306567333543827,"d":"3.07E-04"},"MMP9/TLR9/MTOR/MTNR1B/AKT1/AKT2",6]
["GO:0035601","protein deacylation","6/143","103/18670",{"v":0.000141226493430301,"d":"1.41E-04"},{"v":0.000658623093785553,"d":"6.59E-04"},{"v":0.000306567333543827,"d":"3.07E-04"},"MAPK8/HDAC11/VEGFA/SIRT1/TP53/PRKAA2",6]
["GO:1905269","positive regulation of chromatin organization","6/143","103/18670",{"v":0.000141226493430301,"d":"1.41E-04"},{"v":0.000658623093785553,"d":"6.59E-04"},{"v":0.000306567333543827,"d":"3.07E-04"},"MAPK3/VEGFA/SIRT1/OGT/TP53/IL1B",6]
["GO:0019433","triglyceride catabolic process","4/143","35/18670",{"v":0.000143661909084186,"d":"1.44E-04"},{"v":0.000667673258292519,"d":"6.68E-04"},{"v":0.000310779886713025,"d":"3.11E-04"},"PIK3CG/FABP4/FABP2/LIPE",4]
["GO:0060251","regulation of glial cell proliferation","4/143","35/18670",{"v":0.000143661909084186,"d":"1.44E-04"},{"v":0.000667673258292519,"d":"6.68E-04"},{"v":0.000310779886713025,"d":"3.11E-04"},"MTOR/TNF/IL6/IL1B",4]
["GO:1905332","positive regulation of morphogenesis of an epithelium","4/143","35/18670",{"v":0.000143661909084186,"d":"1.44E-04"},{"v":0.000667673258292519,"d":"6.68E-04"},{"v":0.000310779886713025,"d":"3.11E-04"},"AR/MTOR/ALOX12/VEGFA",4]
["GO:1990778","protein localization to cell periphery","10/143","311/18670",{"v":0.000144291675722952,"d":"1.44E-04"},{"v":0.000669831081796456,"d":"6.70E-04"},{"v":0.000311784282404737,"d":"3.12E-04"},"AR/MAPK10/AKT1/PIK3R1/IKBKB/TNF/HRAS/AKT2/KCNJ11/PRKCZ",10]
["GO:0098732","macromolecule deacylation","6/143","104/18670",{"v":0.000148938676109813,"d":"1.49E-04"},{"v":0.000690611409957069,"d":"6.91E-04"},{"v":0.000321456839978977,"d":"3.21E-04"},"MAPK8/HDAC11/VEGFA/SIRT1/TP53/PRKAA2",6]
["GO:0014857","regulation of skeletal muscle cell proliferation","3/143","14/18670",{"v":0.000150549653111302,"d":"1.51E-04"},{"v":0.000696108782153477,"d":"6.96E-04"},{"v":0.000324015685472936,"d":"3.24E-04"},"STAT3/SHH/FGF2",3]
["GO:1905050","positive regulation of metallopeptidase activity","3/143","14/18670",{"v":0.000150549653111302,"d":"1.51E-04"},{"v":0.000696108782153477,"d":"6.96E-04"},{"v":0.000324015685472936,"d":"3.24E-04"},"MAPK14/MAPK3/STAT3",3]
["GO:0017038","protein import","8/143","199/18670",{"v":0.000150640141592501,"d":"1.51E-04"},{"v":0.000696108782153477,"d":"6.96E-04"},{"v":0.000324015685472936,"d":"3.24E-04"},"MAPK14/PTGS2/MAPK1/STAT3/AKT1/PIK3R1/SHH/TP53",8]
["GO:0051924","regulation of calcium ion transport","9/143","254/18670",{"v":0.000151571153758018,"d":"1.52E-04"},{"v":0.000699612349387068,"d":"7.00E-04"},{"v":0.000325646480497933,"d":"3.26E-04"},"PTGS2/TLR9/PIK3CG/MCHR1/F2/NOS3/CASR/ICAM1/ATP2A1",9]
["GO:0002821","positive regulation of adaptive immune response","6/143","105/18670",{"v":0.000156980579969302,"d":"1.57E-04"},{"v":0.000722932181701631,"d":"7.23E-04"},{"v":0.000336501093521406,"d":"3.37E-04"},"IL2/TNF/SIRT1/IL6/PRKCZ/IL1B",6]
["GO:0006641","triglyceride metabolic process","6/143","105/18670",{"v":0.000156980579969302,"d":"1.57E-04"},{"v":0.000722932181701631,"d":"7.23E-04"},{"v":0.000336501093521406,"d":"3.37E-04"},"PIK3CG/FABP4/FABP2/SIRT1/LIPE/CETP",6]
["GO:0010742","macrophage derived foam cell differentiation","4/143","36/18670",{"v":0.000160663113499124,"d":"1.61E-04"},{"v":0.000735306411439773,"d":"7.35E-04"},{"v":0.000342260889452151,"d":"3.42E-04"},"PPARG/PPARA/AGTR1/CETP",4]
["GO:0046627","negative regulation of insulin receptor signaling pathway","4/143","36/18670",{"v":0.000160663113499124,"d":"1.61E-04"},{"v":0.000735306411439773,"d":"7.35E-04"},{"v":0.000342260889452151,"d":"3.42E-04"},"PRKCB/PTPN1/PRKCZ/IL1B",4]
["GO:0090077","foam cell differentiation","4/143","36/18670",{"v":0.000160663113499124,"d":"1.61E-04"},{"v":0.000735306411439773,"d":"7.35E-04"},{"v":0.000342260889452151,"d":"3.42E-04"},"PPARG/PPARA/AGTR1/CETP",4]
["GO:0097242","amyloid-beta clearance","4/143","36/18670",{"v":0.000160663113499124,"d":"1.61E-04"},{"v":0.000735306411439773,"d":"7.35E-04"},{"v":0.000342260889452151,"d":"3.42E-04"},"IGF1R/HMGCR/INSR/TNF",4]
["GO:2001171","positive regulation of ATP biosynthetic process","4/143","36/18670",{"v":0.000160663113499124,"d":"1.61E-04"},{"v":0.000735306411439773,"d":"7.35E-04"},{"v":0.000342260889452151,"d":"3.42E-04"},"INSR/STAT3/HIF1A/PRKAA2",4]
["GO:0090596","sensory organ morphogenesis","9/143","256/18670",{"v":0.000160757454082065,"d":"1.61E-04"},{"v":0.000735306411439773,"d":"7.35E-04"},{"v":0.000342260889452151,"d":"3.42E-04"},"MAPK1/FGFR1/MAPK3/STAT3/VEGFA/HIF1A/GLI2/CYP26B1/RBP4",9]
["GO:0060038","cardiac muscle cell proliferation","5/143","67/18670",{"v":0.000162050654141383,"d":"1.62E-04"},{"v":0.000740384929982302,"d":"7.40E-04"},{"v":0.000344624772380986,"d":"3.45E-04"},"MAPK14/MAPK1/FGFR1/FGF2/RBP4",5]
["GO:0033673","negative regulation of kinase activity","9/143","257/18670",{"v":0.000165522092309223,"d":"1.66E-04"},{"v":0.00075454215052673,"d":"7.55E-04"},{"v":0.000351214491741951,"d":"3.51E-04"},"IGF1R/HMGCR/AKT1/PTPN1/CASP3/FABP4/SIRT1/PTPN22/IL1B",9]
["GO:0048863","stem cell differentiation","9/143","257/18670",{"v":0.000165522092309223,"d":"1.66E-04"},{"v":0.00075454215052673,"d":"7.55E-04"},{"v":0.000351214491741951,"d":"3.51E-04"},"MAPK1/MAPK3/STAT3/ESR1/SHH/ACE/HIF1A/TP53/NFE2L2",9]
["GO:0032675","regulation of interleukin-6 production","7/143","152/18670",{"v":0.000171246729946949,"d":"1.71E-04"},{"v":0.000779760138161136,"d":"7.80E-04"},{"v":0.000362952633479413,"d":"3.63E-04"},"TLR4/TLR9/STAT3/TNF/IL6/PTPN22/IL1B",7]
["GO:0002292","T cell differentiation involved in immune response","5/143","68/18670",{"v":0.000173843448342912,"d":"1.74E-04"},{"v":0.000788921837322989,"d":"7.89E-04"},{"v":0.000367217102352858,"d":"3.67E-04"},"MTOR/STAT3/IL2/IL6/PRKCZ",5]
["GO:0035924","cellular response to vascular endothelial growth factor stimulus","5/143","68/18670",{"v":0.000173843448342912,"d":"1.74E-04"},{"v":0.000788921837322989,"d":"7.89E-04"},{"v":0.000367217102352858,"d":"3.67E-04"},"MAPK14/FLT1/AKT1/VEGFA/PGF",5]
["GO:0050891","multicellular organismal water homeostasis","5/143","68/18670",{"v":0.000173843448342912,"d":"1.74E-04"},{"v":0.000788921837322989,"d":"7.89E-04"},{"v":0.000367217102352858,"d":"3.67E-04"},"ALOX12/AVPR2/AKR1B1/CFTR/CYP26B1",5]
["GO:0007204","positive regulation of cytosolic calcium ion concentration","10/143","319/18670",{"v":0.000177286012459801,"d":"1.77E-04"},{"v":0.000803643648865931,"d":"8.04E-04"},{"v":0.000374069620207514,"d":"3.74E-04"},"PIK3CG/MCHR1/F2/CNR1/ESR1/AVPR1A/IL2/FGF2/AGTR1/CCR5",10]
["GO:0034250","positive regulation of cellular amide metabolic process","7/143","153/18670",{"v":0.000178323637991139,"d":"1.78E-04"},{"v":0.000806319871171732,"d":"8.06E-04"},{"v":0.000375315313448461,"d":"3.75E-04"},"MAPK1/MTOR/MAPK3/CASP3/TNF/IL6/NFE2L2",7]
["GO:0034405","response to fluid shear stress","4/143","37/18670",{"v":0.000179071532653999,"d":"1.79E-04"},{"v":0.000806319871171732,"d":"8.06E-04"},{"v":0.000375315313448461,"d":"3.75E-04"},"PTGS2/AKT1/NOS3/NFE2L2",4]
["GO:0043243","positive regulation of protein complex disassembly","4/143","37/18670",{"v":0.000179071532653999,"d":"1.79E-04"},{"v":0.000806319871171732,"d":"8.06E-04"},{"v":0.000375315313448461,"d":"3.75E-04"},"IGF1R/INSR/TNF/ADRB2",4]
["GO:0045777","positive regulation of blood pressure","4/143","37/18670",{"v":0.000179071532653999,"d":"1.79E-04"},{"v":0.000806319871171732,"d":"8.06E-04"},{"v":0.000375315313448461,"d":"3.75E-04"},"CNR1/AVPR2/AVPR1A/ACE",4]
["GO:0071542","dopaminergic neuron differentiation","4/143","37/18670",{"v":0.000179071532653999,"d":"1.79E-04"},0.000806319871171732,{"v":0.000375315313448461,"d":"3.75E-04"},"GSK3B/SHH/VEGFA/HIF1A",4]
["GO:0090050","positive regulation of cell migration involved in sprouting angiogenesis","4/143","37/18670",{"v":0.000179071532653999,"d":"1.79E-04"},0.000806319871171732,{"v":0.000375315313448461,"d":"3.75E-04"},"PTGS2/VEGFA/FGF2/HMOX1",4]
["GO:0032526","response to retinoic acid","6/143","108/18670",{"v":0.000183186097662276,"d":"1.83E-04"},0.000823930359263213,{"v":0.000383512414988858,"d":"3.84E-04"},"CLK2/YES1/PPARG/RXRG/CYP26B1/RBP4",6]
["GO:0009415","response to water","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,{"v":0.000386619459743489,"d":"3.87E-04"},"MAPK10/AVPR1A/AKR1B1",3]
["GO:0014856","skeletal muscle cell proliferation","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,{"v":0.000386619459743489,"d":"3.87E-04"},"STAT3/SHH/FGF2",3]
["GO:0017014","protein nitrosylation","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,{"v":0.000386619459743489,"d":"3.87E-04"},"NOS2/ACE/GAPDH",3]
["GO:0018119","peptidyl-cysteine S-nitrosylation","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,{"v":0.000386619459743489,"d":"3.87E-04"},"NOS2/ACE/GAPDH",3]
["GO:0030812","negative regulation of nucleotide catabolic process","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,{"v":0.000386619459743489,"d":"3.87E-04"},"STAT3/PPARA/TP53",3]
["GO:0032352","positive regulation of hormone metabolic process","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,{"v":0.000386619459743489,"d":"3.87E-04"},"TNF/HIF1A/IL1B",3]
["GO:0045410","positive regulation of interleukin-6 biosynthetic process","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,{"v":0.000386619459743489,"d":"3.87E-04"},"STAT3/TNF/IL1B",3]
["GO:0046321","positive regulation of fatty acid oxidation","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,{"v":0.000386619459743489,"d":"3.87E-04"},"PPARG/PPARA/AKT2",3]
["GO:0051198","negative regulation of coenzyme metabolic process","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,0.000386619459743489,"STAT3/PPARA/TP53",3]
["GO:0051770","positive regulation of nitric-oxide synthase biosynthetic process","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,0.000386619459743489,"TLR4/TLR9/NAMPT",3]
["GO:0071474","cellular hyperosmotic response","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,0.000386619459743489,"MAPK10/SLC2A1/AKR1B1",3]
["GO:2001028","positive regulation of endothelial cell chemotaxis","3/143","15/18670",{"v":0.000187132458056848,"d":"1.87E-04"},0.000830605471726011,0.000386619459743489,"FGFR1/VEGFA/FGF2",3]
["GO:0042692","muscle cell differentiation","11/143","385/18670",{"v":0.000188893753242639,"d":"1.89E-04"},0.000837504833654109,0.000389830885230095,"MAPK14/MTOR/AKT1/CASP3/AVPR1A/PPARA/SHH/VEGFA/SIRT1/PARP2/CYP26B1",11]
["GO:0051149","positive regulation of muscle cell differentiation","6/143","109/18670",{"v":0.000192649226666264,"d":"1.93E-04"},0.000853221082653211,0.000397146280931259,"MAPK14/MTOR/SHH/SIRT1/PARP2/CYP26B1",6]
["GO:0016570","histone modification","12/143","454/18670",{"v":0.000198171029387697,"d":"1.98E-04"},0.000873502125568537,0.000406586437686624,"MAPK8/PRKCB/MAPK3/HDAC11/VEGFA/SIRT1/SETD7/PRMT7/OGT/TP53/PRKAA2/IL1B",12]
["GO:0016572","histone phosphorylation","4/143","38/18670",{"v":0.000198954782552913,"d":"1.99E-04"},0.000873502125568537,0.000406586437686624,"PRKCB/MAPK3/PRKAA2/IL1B",4]
["GO:0032350","regulation of hormone metabolic process","4/143","38/18670",{"v":0.000198954782552913,"d":"1.99E-04"},0.000873502125568537,0.000406586437686624,"VDR/TNF/HIF1A/IL1B",4]
["GO:0050892","intestinal absorption","4/143","38/18670",{"v":0.000198954782552913,"d":"1.99E-04"},0.000873502125568537,0.000406586437686624,"KCNQ1/VDR/FABP2/SLC5A1",4]
["GO:0060045","positive regulation of cardiac muscle cell proliferation","4/143","38/18670",{"v":0.000198954782552913,"d":"1.99E-04"},0.000873502125568537,0.000406586437686624,"MAPK14/MAPK1/FGFR1/FGF2",4]
["GO:0060416","response to growth hormone","4/143","38/18670",{"v":0.000198954782552913,"d":"1.99E-04"},0.000873502125568537,0.000406586437686624,"STAT3/AKT1/PIK3R1/PTPN1",4]
["GO:1900077","negative regulation of cellular response to insulin stimulus","4/143","38/18670",{"v":0.000198954782552913,"d":"1.99E-04"},0.000873502125568537,0.000406586437686624,"PRKCB/PTPN1/PRKCZ/IL1B",4]
["GO:1905898","positive regulation of response to endoplasmic reticulum stress","4/143","38/18670",{"v":0.000198954782552913,"d":"1.99E-04"},0.000873502125568537,0.000406586437686624,"PIK3R1/PTPN1/SIRT1/NFE2L2",4]
["GO:0072091","regulation of stem cell proliferation","5/143","70/18670",0.000199384629583017,0.000874440932342418,0.000407023421284826,"SHH/VEGFA/ACE/HIF1A/TP53",5]
["GO:0007259","JAK-STAT cascade","7/143","156/18670",0.000200986109053483,0.000880510572996211,0.000409848638876435,"F2/STAT3/PTPN1/IL2/AKR1B1/TNF/IL6",7]
["GO:0033559","unsaturated fatty acid metabolic process","6/143","110/18670",0.000202494107721596,0.000886157997899482,0.000412477328957789,"PTGS2/MAPK3/ALOX12/AVPR1A/SIRT1/IL1B",6]
["GO:0050670","regulation of lymphocyte proliferation","8/143","208/18670",0.000203860422469338,0.000891173855459912,0.000414812045265561,"TLR4/TLR9/CASP3/IL2/SHH/IL6/PTPN22/IL1B",8]
["GO:0032944","regulation of mononuclear cell proliferation","8/143","209/18670",0.000210623130822842,0.000919743725534914,0.000428110377758346,"TLR4/TLR9/CASP3/IL2/SHH/IL6/PTPN22/IL1B",8]
["GO:0050795","regulation of behavior","5/143","71/18670",0.000213180001956197,0.000928904895499123,0.000432374600307736,"MTOR/MTNR1B/STAT3/CNR1/MC4R",5]
["GO:0071479","cellular response to ionizing radiation","5/143","71/18670",0.000213180001956197,0.000928904895499123,0.000432374600307736,"MAPK14/NAMPT/HRAS/SIRT1/TP53",5]
["GO:0043523","regulation of neuron apoptotic process","8/143","210/18670",0.000217569022964972,0.000947010112862586,0.000440801982011657,"PIK3CA/MTNR1B/CASP3/TNF/HRAS/HMOX1/HIF1A/TP53",8]
["GO:0010874","regulation of cholesterol efflux","4/143","39/18670",0.000220381261934718,0.00095719243381088,0.000445541516673985,"PON1/SHH/SIRT1/CETP",4]
["GO:1902042","negative regulation of extrinsic apoptotic signaling pathway via death domain receptors","4/143","39/18670",0.000220381261934718,0.00095719243381088,0.000445541516673985,"NOS3/SERPINE1/HMOX1/ICAM1",4]
["GO:0015918","sterol transport","6/143","112/18670",0.000223372983903899,0.000968109035163794,0.00045062283465342,"PPARG/PON1/SHH/CFTR/SIRT1/CETP",6]
["GO:0032411","positive regulation of transporter activity","6/143","112/18670",0.000223372983903899,0.000968109035163794,0.00045062283465342,"PON1/CFTR/SGK1/KCNJ11/ADRB2/ATP2A1",6]
["GO:1903531","negative regulation of secretion by cell","8/143","211/18670",0.000224701880971352,0.000972826967028913,0.000452818876373454,"HMGCR/MTNR1B/CNR1/TNF/HMOX1/KCNJ11/PTPN22/IL1B",8]
["GO:0002532","production of molecular mediator involved in inflammatory response","5/143","72/18670",0.000227690509443015,0.000983138605172714,0.000457618603926346,"TLR4/NOS2/MAPK14/F2/SERPINE1",5]
["GO:0051155","positive regulation of striated muscle cell differentiation","5/143","72/18670",0.000227690509443015,0.000983138605172714,0.000457618603926346,"MAPK14/MTOR/SHH/PARP2/CYP26B1",5]
["GO:0002295","T-helper cell lineage commitment","3/143","16/18670",0.000229026606886825,0.000983138605172714,0.000457618603926346,"MTOR/STAT3/IL6",3]
["GO:0019372","lipoxygenase pathway","3/143","16/18670",0.000229026606886825,0.000983138605172714,0.000457618603926346,"PTGS2/ALOX12/PON1",3]
["GO:0045722","positive regulation of gluconeogenesis","3/143","16/18670",0.000229026606886825,0.000983138605172714,0.000457618603926346,"PPARA/SIRT1/FOXO1",3]
["GO:0060572","morphogenesis of an epithelial bud","3/143","16/18670",0.000229026606886825,0.000983138605172714,0.000457618603926346,"AR/SHH/GLI2",3]
["GO:0060965","negative regulation of gene silencing by miRNA","3/143","16/18670",0.000229026606886825,0.000983138605172714,0.000457618603926346,"ESR1/PPARG/TP53",3]
["GO:0071380","cellular response to prostaglandin E stimulus","3/143","16/18670",0.000229026606886825,0.000983138605172714,0.000457618603926346,"AKT1/PPARG/PRKAA2",3]
["GO:0006801","superoxide metabolic process","5/143","73/18670",0.000242940572472309,0.00103955965895128,0.000483880744103074,"NOS2/NOS3/ALOX12/TNF/NFE2L2",5]
["GO:0045685","regulation of glial cell differentiation","5/143","73/18670",0.000242940572472309,0.00103955965895128,0.000483880744103074,"F2/MTOR/PPARG/SHH/IL6",5]
["GO:1901983","regulation of protein acetylation","5/143","73/18670",0.000242940572472309,0.00103955965895128,0.000483880744103074,"GSK3B/MAPK3/SIRT1/PRKAA2/IL1B",5]
["GO:0051604","protein maturation","11/143","397/18670",0.000246000022455121,0.0010515396947184,0.000489457055737971,"BACE2/REN/F2/CASP3/PLAT/SHH/SERPINE1/PCSK7/ACE/OGT/IL1B",11]
["GO:0030336","negative regulation of cell migration","10/143","334/18670",0.000256392640536507,0.00109480739334576,0.00050959674279408,"STAT3/AKT1/CYP19A1/PPARG/SHH/FGF2/SERPINE1/IGFBP3/HMOX1/NFE2L2",10]
["GO:0032963","collagen metabolic process","6/143","115/18670",0.000257833033630994,0.00109979780836487,0.000511919616437778,"MMP9/F2/PPARG/MMP2/IL6/HIF1A",6]
["GO:0030104","water homeostasis","5/143","74/18670",0.000258954973020329,0.00110110265838896,0.000512526981099501,"ALOX12/AVPR2/AKR1B1/CFTR/CYP26B1",5]
["GO:0031670","cellular response to nutrient","5/143","74/18670",0.000258954973020329,0.00110110265838896,0.000512526981099501,"PTGS2/VDR/PPARG/HMOX1/CASR",5]
["GO:0043367","CD4-positive, alpha-beta T cell differentiation","5/143","74/18670",0.000258954973020329,0.00110110265838896,0.000512526981099501,"MTOR/STAT3/IL2/IL6/PRKCZ",5]
["GO:0031214","biomineral tissue development","7/143","163/18670",0.000262987391987002,0.00111707551181887,0.000519961817702252,"PTGS2/NOS3/PPARA/FOXO1/HIF1A/EIF2AK3/ADRB2",7]
["GO:0042572","retinol metabolic process","4/143","41/18670",0.000268141127569774,0.0011377728348034,0.000529595739103934,"AKR1B1/TTR/CYP3A4/RBP4",4]
["GO:1903201","regulation of oxidative stress-induced cell death","5/143","75/18670",0.000275758849117597,0.00116853800898662,0.000543915913273882,"TLR4/AKT1/SIRT1/HIF1A/NFE2L2",5]
["GO:0030540","female genitalia development","3/143","17/18670",0.000276546297581319,0.00116853800898662,0.000543915913273882,"CYP19A1/ESR1/RBP4",3]
["GO:0043373","CD4-positive, alpha-beta T cell lineage commitment","3/143","17/18670",0.000276546297581319,0.00116853800898662,0.000543915913273882,"MTOR/STAT3/IL6",3]
["GO:0060644","mammary gland epithelial cell differentiation","3/143","17/18670",0.000276546297581319,0.00116853800898662,0.000543915913273882,"AKT1/AKT2/HIF1A",3]
["GO:0019722","calcium-mediated signaling","8/143","218/18670",0.00028019533687968,0.00118272233961308,0.000550518251484142,"GSK3B/SELP/MTOR/AVPR1A/TNF/EIF2AK3/AGTR1/CCR5",8]
["GO:0010822","positive regulation of mitochondrion organization","6/143","117/18670",0.000283036261398543,0.0011922276650794,0.000554942667072011,"GSK3B/MAPK8/MMP9/HK2/HIF1A/TP53",6]
["GO:0051153","regulation of striated muscle cell differentiation","6/143","117/18670",0.000283036261398543,0.0011922276650794,0.000554942667072011,"MAPK14/MTOR/PPARA/SHH/PARP2/CYP26B1",6]
["GO:0046902","regulation of mitochondrial membrane permeability","5/143","76/18670",0.000293377689245411,0.00123404859566063,0.000574408931306565,"GSK3B/MAPK8/STAT3/HK2/TP53",5]
["GO:0016569","covalent chromatin modification","12/143","474/18670",0.000293714122933541,0.00123404859566063,0.000574408931306565,"MAPK8/PRKCB/MAPK3/HDAC11/VEGFA/SIRT1/SETD7/PRMT7/OGT/TP53/PRKAA2/IL1B",12]
["GO:0097696","STAT cascade","7/143","166/18670",0.000293879161614834,0.00123404859566063,0.000574408931306565,"F2/STAT3/PTPN1/IL2/AKR1B1/TNF/IL6",7]
["GO:0002639","positive regulation of immunoglobulin production","4/143","42/18670",0.000294614793365327,0.00123585563061435,0.000575250046494612,"TLR9/IL2/IL6/RBP4",4]
["GO:1901568","fatty acid derivative metabolic process","7/143","167/18670",0.000304800959476302,0.00127726116351974,0.000594522956807869,"PTGS2/MAPK3/ALOX12/AVPR1A/PON1/SIRT1/IL1B",7]
["GO:0007188","adenylate cyclase-modulating G protein-coupled receptor signaling pathway","8/143","221/18670",0.000307182187302121,0.00128590847383556,0.000598547994634296,"ADRB3/MCHR1/CNR1/AVPR2/GCGR/ADRB2/CASR/MC4R",8]
["GO:0016575","histone deacetylation","5/143","77/18670",0.000311837326627183,0.00130404700225913,0.000606990881538339,"MAPK8/HDAC11/VEGFA/SIRT1/TP53",5]
["GO:0050806","positive regulation of synaptic transmission","7/143","168/18670",0.000316046512217187,0.00132028512018078,0.000614549190015495,"GSK3B/PTGS2/MAPK1/CNR1/TNF/PRKCZ/ADRB2",7]
["GO:0070663","regulation of leukocyte proliferation","8/143","222/18670",0.000316635941048322,0.00132037491932699,0.000614590988557135,"TLR4/TLR9/CASP3/IL2/SHH/IL6/PTPN22/IL1B",8]
["GO:0006913","nucleocytoplasmic transport","10/143","343/18670",0.000316720367259514,0.00132037491932699,0.000614590988557135,"GSK3B/MAPK14/PTGS2/MAPK1/STAT3/AKT1/PIK3R1/SHH/TP53/IL1B",10]
["GO:0006692","prostanoid metabolic process","4/143","43/18670",0.000322912155882114,0.00133655256340573,0.000622121148454402,"PTGS2/AVPR1A/SIRT1/IL1B",4]
["GO:0006693","prostaglandin metabolic process","4/143","43/18670",0.000322912155882114,0.00133655256340573,0.000622121148454402,"PTGS2/AVPR1A/SIRT1/IL1B",4]
["GO:0008631","intrinsic apoptotic signaling pathway in response to oxidative stress","4/143","43/18670",0.000322912155882114,0.00133655256340573,0.000622121148454402,"AKT1/SIRT1/HIF1A/NFE2L2",4]
["GO:0042088","T-helper 1 type immune response","4/143","43/18670",0.000322912155882114,0.00133655256340573,0.000622121148454402,"TLR4/MTOR/HRAS/IL1B",4]
["GO:0046461","neutral lipid catabolic process","4/143","43/18670",0.000322912155882114,0.00133655256340573,0.000622121148454402,"PIK3CG/FABP4/FABP2/LIPE",4]
["GO:0046464","acylglycerol catabolic process","4/143","43/18670",0.000322912155882114,0.00133655256340573,0.000622121148454402,"PIK3CG/FABP4/FABP2/LIPE",4]
["GO:0060612","adipose tissue development","4/143","43/18670",0.000322912155882114,0.00133655256340573,0.000622121148454402,"PIK3CA/SIRT1/CASR/FTO",4]
["GO:0010721","negative regulation of cell development","10/143","344/18670",0.000324101116530024,0.00134010349306797,0.000623773989128266,"GSK3B/F2/STAT3/PPARA/SHH/TNF/VEGFA/IL6/TP53/IL1B",10]
["GO:0030307","positive regulation of cell growth","7/143","169/18670",0.000327622844317211,0.00135328293244497,0.000629908583595926,"F2/MTOR/AKT1/AVPR1A/IL2/VEGFA/PARP2",7]
["GO:0044320","cellular response to leptin stimulus","3/143","18/18670",0.000329997733722285,0.00136031652353137,0.000633182488329821,"GCK/STAT3/SIRT1",3]
["GO:0150078","positive regulation of neuroinflammatory response","3/143","18/18670",0.000329997733722285,0.00136031652353137,0.000633182488329821,"TNF/IL6/IL1B",3]
["GO:0008306","associative learning","5/143","78/18670",0.000331163933419698,0.00136234918951518,0.0006341286273227,"HMGCR/MTOR/HRH1/FOS/HIF1A",5]
["GO:0090398","cellular senescence","5/143","78/18670",0.000331163933419698,0.00136234918951518,0.0006341286273227,"MAPK14/NAMPT/HRAS/SIRT1/TP53",5]
["GO:0051169","nuclear transport","10/143","346/18670",{"v":0.000339294649314821,"d":"3.39E-04"},{"v":0.0013943804471334,"d":"1.39E-03"},{"v":0.000649038121585391,"d":"6.49E-04"},"GSK3B/MAPK14/PTGS2/MAPK1/STAT3/AKT1/PIK3R1/SHH/TP53/IL1B",10]
["GO:1900034","regulation of cellular response to heat","5/143","79/18670",{"v":0.000351384014809272,"d":"3.51E-04"},{"v":0.00144139655558554,"d":"1.44E-03"},{"v":0.000670922569819565,"d":"6.71E-04"},"GSK3B/MAPK1/MTOR/MAPK3/SIRT1",5]
["GO:0046486","glycerolipid metabolic process","11/143","414/18670",{"v":0.000351447233291237,"d":"3.51E-04"},{"v":0.00144139655558554,"d":"1.44E-03"},{"v":0.000670922569819565,"d":"6.71E-04"},"PIK3CA/PIK3CG/PIK3R1/PON1/FABP4/FABP2/FGF2/AGPAT2/SIRT1/LIPE/CETP",11]
["GO:0045601","regulation of endothelial cell differentiation","4/143","44/18670",{"v":0.000353104820351765,"d":"3.53E-04"},{"v":0.00144380637654944,"d":"1.44E-03"},{"v":0.000672044262019839,"d":"6.72E-04"},"IKBKB/TNF/VEGFA/IL1B",4]
["GO:0061756","leukocyte adhesion to vascular endothelial cell","4/143","44/18670",{"v":0.000353104820351765,"d":"3.53E-04"},{"v":0.00144380637654944,"d":"1.44E-03"},{"v":0.000672044262019839,"d":"6.72E-04"},"SELP/TNF/ICAM1/SELL",4]
["GO:0090311","regulation of protein deacetylation","4/143","44/18670",{"v":0.000353104820351765,"d":"3.53E-04"},{"v":0.00144380637654944,"d":"1.44E-03"},{"v":0.000672044262019839,"d":"6.72E-04"},"MAPK8/VEGFA/TP53/PRKAA2",4]
["GO:0034101","erythrocyte homeostasis","6/143","122/18670",{"v":0.000354555175398499,"d":"3.55E-04"},{"v":0.0014482738143422,"d":"1.45E-03"},{"v":0.00067412370700867,"d":"6.74E-04"},"MAPK14/STAT3/CASP3/VEGFA/HMOX1/HIF1A",6]
["GO:0034976","response to endoplasmic reticulum stress","9/143","285/18670",{"v":0.000355556294678087,"d":"3.56E-04"},{"v":0.00145089907344445,"d":"1.45E-03"},{"v":0.000675345678558761,"d":"6.75E-04"},"GSK3B/PIK3R1/PTPN1/CFTR/SIRT1/EIF2AK3/TP53/NFE2L2/ATP2A1",9]
["GO:2000146","negative regulation of cell motility","10/143","349/18670",{"v":0.000363198095634737,"d":"3.63E-04"},{"v":0.00148059002127837,"d":"1.48E-03"},{"v":0.000689165835783304,"d":"6.89E-04"},"STAT3/AKT1/CYP19A1/PPARG/SHH/FGF2/SERPINE1/IGFBP3/HMOX1/NFE2L2",10]
["GO:0051262","protein tetramerization","7/143","172/18670",{"v":0.000364408101359411,"d":"3.64E-04"},{"v":0.00148402816328259,"d":"1.48E-03"},{"v":0.000690766177521281,"d":"6.91E-04"},"IGF1R/HMGCR/INSR/IMPDH2/TRPM6/TP53/ACACB",7]
["GO:0022617","extracellular matrix disassembly","5/143","80/18670",{"v":0.000372524403017662,"d":"3.73E-04"},{"v":0.00151555656624673,"d":"1.52E-03"},{"v":0.000705441609522998,"d":"7.05E-04"},"MMP9/MMP2/DPP4/IL6/CTRB1",5]
["GO:0002363","alpha-beta T cell lineage commitment","3/143","19/18670",{"v":0.000389679248255406,"d":"3.90E-04"},{"v":0.00157427305083621,"d":"1.57E-03"},{"v":0.000732772197055548,"d":"7.33E-04"},"MTOR/STAT3/IL6",3]
["GO:0002726","positive regulation of T cell cytokine production","3/143","19/18670",{"v":0.000389679248255406,"d":"3.90E-04"},{"v":0.00157427305083621,"d":"1.57E-03"},{"v":0.000732772197055548,"d":"7.33E-04"},"IL6/PRKCZ/IL1B",3]
["GO:0010544","negative regulation of platelet activation","3/143","19/18670",{"v":0.000389679248255406,"d":"3.90E-04"},{"v":0.00157427305083621,"d":"1.57E-03"},{"v":0.000732772197055548,"d":"7.33E-04"},"F2/NOS3/ALOX12",3]
["GO:0045414","regulation of interleukin-8 biosynthetic process","3/143","19/18670",{"v":0.000389679248255406,"d":"3.90E-04"},{"v":0.00157427305083621,"d":"1.57E-03"},{"v":0.000732772197055548,"d":"7.33E-04"},"TLR4/TLR9/TNF",3]
["GO:0060149","negative regulation of posttranscriptional gene silencing","3/143","19/18670",{"v":0.000389679248255406,"d":"3.90E-04"},{"v":0.00157427305083621,"d":"1.57E-03"},{"v":0.000732772197055548,"d":"7.33E-04"},"ESR1/PPARG/TP53",3]
["GO:0060438","trachea development","3/143","19/18670",{"v":0.000389679248255406,"d":"3.90E-04"},{"v":0.00157427305083621,"d":"1.57E-03"},{"v":0.000732772197055548,"d":"7.33E-04"},"MAPK1/MAPK3/SHH",3]
["GO:0060967","negative regulation of gene silencing by RNA","3/143","19/18670",{"v":0.000389679248255406,"d":"3.90E-04"},{"v":0.00157427305083621,"d":"1.57E-03"},{"v":0.000732772197055548,"d":"7.33E-04"},"ESR1/PPARG/TP53",3]
["GO:2001252","positive regulation of chromosome organization","7/143","174/18670",{"v":0.000390718303836036,"d":"3.91E-04"},{"v":0.00157689700291952,"d":"1.58E-03"},{"v":0.000733993560231417,"d":"7.34E-04"},"MAPK1/MAPK3/VEGFA/SIRT1/OGT/TP53/IL1B",7]
["GO:0031929","TOR signaling","6/143","125/18670",{"v":0.000403808494247763,"d":"4.04E-04"},{"v":0.00162810436724596,"d":"1.63E-03"},{"v":0.000757828899877853,"d":"7.58E-04"},"PIK3CA/MTOR/AKT1/SIRT1/HIF1A/PRKAA2",6]
["GO:1905954","positive regulation of lipid localization","5/143","82/18670",{"v":0.00041767502739677,"d":"4.18E-04"},{"v":0.00168233682676828,"d":"1.68E-03"},{"v":0.000783072321592269,"d":"7.83E-04"},"CYP19A1/PON1/SIRT1/ACACB/IL1B",5]
["GO:0022602","ovulation cycle process","4/143","46/18670",{"v":0.000419464968974595,"d":"4.19E-04"},{"v":0.00168284855739263,"d":"1.68E-03"},{"v":0.000783310515324736,"d":"7.83E-04"},"NOS3/ESR1/CASP3/SIRT1",4]
["GO:0060443","mammary gland morphogenesis","4/143","46/18670",{"v":0.000419464968974595,"d":"4.19E-04"},{"v":0.00168284855739263,"d":"1.68E-03"},{"v":0.000783310515324736,"d":"7.83E-04"},"AR/ESR1/VDR/GLI2",4]
["GO:0071675","regulation of mononuclear cell migration","4/143","46/18670",{"v":0.000419464968974595,"d":"4.19E-04"},{"v":0.00168284855739263,"d":"1.68E-03"},{"v":0.000783310515324736,"d":"7.83E-04"},"MAPK14/MAPK3/TNF/SERPINE1",4]
["GO:1900015","regulation of cytokine production involved in inflammatory response","4/143","46/18670",{"v":0.000419464968974595,"d":"4.19E-04"},{"v":0.00168284855739263,"d":"1.68E-03"},{"v":0.000783310515324736,"d":"7.83E-04"},"TLR4/NOS2/MAPK14/F2",4]
["GO:0018107","peptidyl-threonine phosphorylation","6/143","126/18670",{"v":0.000421361863129243,"d":"4.21E-04"},{"v":0.00168878497222493,"d":"1.69E-03"},{"v":0.00078607372068926,"d":"7.86E-04"},"GSK3B/MAPK1/MAPK8/PRKCB/MTOR/AKT1",6]
["GO:0009410","response to xenobiotic stimulus","9/143","292/18670",{"v":0.000424171661757821,"d":"4.24E-04"},{"v":0.00169836487319056,"d":"1.70E-03"},{"v":0.000790532848713103,"d":"7.91E-04"},"MTOR/CNR1/PPARG/HNF4A/CYP3A4/AOC3/FOXO1/CYP26B1/ICAM1",9]
["GO:0006417","regulation of translation","11/143","424/18670",{"v":0.000429633131367172,"d":"4.30E-04"},{"v":0.00171853252546869,"d":"1.72E-03"},{"v":0.000799920225865652,"d":"8.00E-04"},"MAPK1/MTOR/MAPK3/STAT3/AKT1/TNF/AKT2/GAPDH/IL6/EIF2AK3/FTO",11]
["GO:0001959","regulation of cytokine-mediated signaling pathway","7/143","177/18670",{"v":0.000433013962274006,"d":"4.33E-04"},{"v":0.00172863956537,"d":"1.73E-03"},{"v":0.000804624719682831,"d":"8.05E-04"},"IKBKB/PTPN1/PPARG/TNF/AGPAT2/IL6/HIF1A",7]
["GO:0048469","cell maturation","7/143","177/18670",{"v":0.000433013962274006,"d":"4.33E-04"},{"v":0.00172863956537,"d":"1.73E-03"},{"v":0.000804624719682831,"d":"8.05E-04"},"FGFR1/REN/MTOR/PPARG/CFTR/VEGFA/HIF1A",7]
["GO:0045058","T cell selection","4/143","47/18670",{"v":0.000455778030191959,"d":"4.56E-04"},{"v":0.00180922354041388,"d":"1.81E-03"},{"v":0.000842133902990652,"d":"8.42E-04"},"MTOR/STAT3/SHH/IL6",4]
["GO:1903580","positive regulation of ATP metabolic process","4/143","47/18670",{"v":0.000455778030191959,"d":"4.56E-04"},{"v":0.00180922354041388,"d":"1.81E-03"},{"v":0.000842133902990652,"d":"8.42E-04"},"INSR/STAT3/HIF1A/PRKAA2",4]
["GO:2001239","regulation of extrinsic apoptotic signaling pathway in absence of ligand","4/143","47/18670",{"v":0.000455778030191959,"d":"4.56E-04"},{"v":0.00180922354041388,"d":"1.81E-03"},{"v":0.000842133902990652,"d":"8.42E-04"},"FGFR1/AKT1/TNF/IL1B",4]
["GO:0042228","interleukin-8 biosynthetic process","3/143","20/18670",{"v":0.000455881425697174,"d":"4.56E-04"},{"v":0.00180922354041388,"d":"1.81E-03"},{"v":0.000842133902990652,"d":"8.42E-04"},"TLR4/TLR9/TNF",3]
["GO:0051767","nitric-oxide synthase biosynthetic process","3/143","20/18670",{"v":0.000455881425697174,"d":"4.56E-04"},{"v":0.00180922354041388,"d":"1.81E-03"},{"v":0.000842133902990652,"d":"8.42E-04"},"TLR4/TLR9/NAMPT",3]
["GO:0051769","regulation of nitric-oxide synthase biosynthetic process","3/143","20/18670",{"v":0.000455881425697174,"d":"4.56E-04"},{"v":0.00180922354041388,"d":"1.81E-03"},{"v":0.000842133902990652,"d":"8.42E-04"},"TLR4/TLR9/NAMPT",3]
["GO:0048568","embryonic organ development","11/143","428/18670",{"v":0.000464756036767131,"d":"4.65E-04"},{"v":0.00184263705860269,"d":"1.84E-03"},{"v":0.000857686793972023,"d":"8.58E-04"},"MAPK1/FGFR1/MAPK3/AKT1/SHH/TNF/VEGFA/HIF1A/GLI2/TP53/RBP4",11]
["GO:0045445","myoblast differentiation","5/143","84/18670",{"v":0.000466836772030737,"d":"4.67E-04"},{"v":0.00184726808717539,"d":"1.85E-03"},{"v":0.000859842385074876,"d":"8.60E-04"},"MAPK14/HMGCR/SHH/TNF/IGFBP3",5]
["GO:1905897","regulation of response to endoplasmic reticulum stress","5/143","84/18670",{"v":0.000466836772030737,"d":"4.67E-04"},{"v":0.00184726808717539,"d":"1.85E-03"},{"v":0.000859842385074876,"d":"8.60E-04"},"PIK3R1/PTPN1/SIRT1/EIF2AK3/NFE2L2",5]
["GO:0002460","adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains","10/143","361/18670",{"v":0.000473346663941861,"d":"4.73E-04"},{"v":0.00187119853089517,"d":"1.87E-03"},{"v":0.000870981217573943,"d":"8.71E-04"},"TLR4/MTOR/STAT3/IL2/TNF/HRAS/IL6/PRKCZ/ICAM1/IL1B",10]
["GO:0006639","acylglycerol metabolic process","6/143","129/18670",{"v":0.000477618937966881,"d":"4.78E-04"},{"v":0.001884406881959,"d":"1.88E-03"},{"v":0.000877129269478524,"d":"8.77E-04"},"PIK3CG/FABP4/FABP2/SIRT1/LIPE/CETP",6]
["GO:1903038","negative regulation of leukocyte cell-cell adhesion","6/143","129/18670",{"v":0.000477618937966881,"d":"4.78E-04"},{"v":0.001884406881959,"d":"1.88E-03"},{"v":0.000877129269478524,"d":"8.77E-04"},"AKT1/CASP3/PPARA/IL2/SHH/PTPN22",6]
["GO:0034308","primary alcohol metabolic process","5/143","85/18670",{"v":0.000492992193927937,"d":"4.93E-04"},{"v":0.00193691692202501,"d":"1.94E-03"},{"v":0.000901570961728929,"d":"9.02E-04"},"ALDH2/AKR1B1/TTR/CYP3A4/RBP4",5]
["GO:0007595","lactation","4/143","48/18670",{"v":0.000494277465526639,"d":"4.94E-04"},{"v":0.00193691692202501,"d":"1.94E-03"},{"v":0.000901570961728929,"d":"9.02E-04"},"VDR/HK2/VEGFA/HIF1A",4]
["GO:0008542","visual learning","4/143","48/18670",{"v":0.000494277465526639,"d":"4.94E-04"},{"v":0.00193691692202501,"d":"1.94E-03"},{"v":0.000901570961728929,"d":"9.02E-04"},"HMGCR/MTOR/HRH1/HIF1A",4]
["GO:0009311","oligosaccharide metabolic process","4/143","48/18670",{"v":0.000494277465526639,"d":"4.94E-04"},{"v":0.00193691692202501,"d":"1.94E-03"},{"v":0.000901570961728929,"d":"9.02E-04"},"BRAF/SLC2A1/MGAM/TREH",4]
["GO:0035272","exocrine system development","4/143","48/18670",{"v":0.000494277465526639,"d":"4.94E-04"},{"v":0.00193691692202501,"d":"1.94E-03"},{"v":0.000901570961728929,"d":"9.02E-04"},"FGFR1/INSR/SHH/TNF",4]
["GO:0051972","regulation of telomerase activity","4/143","48/18670",{"v":0.000494277465526639,"d":"4.94E-04"},{"v":0.00193691692202501,"d":"1.94E-03"},{"v":0.000901570961728929,"d":"9.02E-04"},"MAPK1/MAPK3/PPARG/TP53",4]
["GO:0072604","interleukin-6 secretion","4/143","48/18670",{"v":0.000494277465526639,"d":"4.94E-04"},{"v":0.00193691692202501,"d":"1.94E-03"},{"v":0.000901570961728929,"d":"9.02E-04"},"NOS2/TNF/PTPN22/IL1B",4]
["GO:0051147","regulation of muscle cell differentiation","7/143","181/18670",{"v":0.000495018359539446,"d":"4.95E-04"},{"v":0.00193794421606932,"d":"1.94E-03"},{"v":0.000902049133233847,"d":"9.02E-04"},"MAPK14/MTOR/PPARA/SHH/SIRT1/PARP2/CYP26B1",7]
["GO:0006638","neutral lipid metabolic process","6/143","130/18670",{"v":0.000497616624515232,"d":"4.98E-04"},{"v":0.00194435530505565,"d":"1.94E-03"},{"v":0.000905033283765764,"d":"9.05E-04"},"PIK3CG/FABP4/FABP2/SIRT1/LIPE/CETP",6]
["GO:0050671","positive regulation of lymphocyte proliferation","6/143","130/18670",{"v":0.000497616624515232,"d":"4.98E-04"},{"v":0.00194435530505565,"d":"1.94E-03"},{"v":0.000905033283765764,"d":"9.05E-04"},"TLR4/TLR9/IL2/SHH/IL6/IL1B",6]
["GO:0010821","regulation of mitochondrion organization","7/143","182/18670",{"v":0.000511574637375524,"d":"5.12E-04"},{"v":0.00199696637617755,"d":"2.00E-03"},{"v":0.000929522002641412,"d":"9.30E-04"},"GSK3B/MAPK8/MMP9/AKT1/HK2/HIF1A/TP53",7]
["GO:0032946","positive regulation of mononuclear cell proliferation","6/143","131/18670",{"v":0.000518260536196531,"d":"5.18E-04"},{"v":0.00202111623364504,"d":"2.02E-03"},{"v":0.000940762965005364,"d":"9.41E-04"},"TLR4/TLR9/IL2/SHH/IL6/IL1B",6]
["GO:0070542","response to fatty acid","5/143","86/18670",{"v":0.000520235437854045,"d":"5.20E-04"},{"v":0.00202686530551797,"d":"2.03E-03"},{"v":0.000943438968399515,"d":"9.43E-04"},"PTGS2/AKT1/PPARG/PON1/PRKAA2",5]
["GO:0042391","regulation of membrane potential","11/143","434/18670",{"v":0.000521938323958997,"d":"5.22E-04"},{"v":0.00203154455325579,"d":"2.03E-03"},{"v":0.00094561700393381,"d":"9.46E-04"},"GSK3B/MTNR1B/KCNQ1/AKT1/CNR1/ALOX12/CFTR/AKT2/KCNJ11/PRKCZ/ADRB2",11]
["GO:0010829","negative regulation of glucose transmembrane transport","3/143","21/18670",{"v":0.00052888722280454,"d":"5.29E-04"},{"v":0.00204482853668842,"d":"2.04E-03"},{"v":0.000951800260212262,"d":"9.52E-04"},"PRKCB/TNF/IL1B",3]
["GO:0030277","maintenance of gastrointestinal epithelium","3/143","21/18670",{"v":0.00052888722280454,"d":"5.29E-04"},{"v":0.00204482853668842,"d":"2.04E-03"},{"v":0.000951800260212262,"d":"9.52E-04"},"TLR4/TLR9/RBP4",3]
["GO:0030728","ovulation","3/143","21/18670",{"v":0.00052888722280454,"d":"5.29E-04"},{"v":0.00204482853668842,"d":"2.04E-03"},{"v":0.000951800260212262,"d":"9.52E-04"},"PTGS2/NOS3/SIRT1",3]
["GO:0035743","CD4-positive, alpha-beta T cell cytokine production","3/143","21/18670",{"v":0.00052888722280454,"d":"5.29E-04"},0.00204482853668842,{"v":0.000951800260212262,"d":"9.52E-04"},"IL6/PRKCZ/IL1B",3]
["GO:0035813","regulation of renal sodium excretion","3/143","21/18670",{"v":0.00052888722280454,"d":"5.29E-04"},0.00204482853668842,{"v":0.000951800260212262,"d":"9.52E-04"},"AVPR2/AVPR1A/AGTR1",3]
["GO:0036499","PERK-mediated unfolded protein response","3/143","21/18670",{"v":0.00052888722280454,"d":"5.29E-04"},0.00204482853668842,{"v":0.000951800260212262,"d":"9.52E-04"},"PTPN1/EIF2AK3/NFE2L2",3]
["GO:0046827","positive regulation of protein export from nucleus","3/143","21/18670",{"v":0.00052888722280454,"d":"5.29E-04"},0.00204482853668842,{"v":0.000951800260212262,"d":"9.52E-04"},"GSK3B/TP53/IL1B",3]
["GO:0002534","cytokine production involved in inflammatory response","4/143","49/18670",{"v":0.000535037000888595,"d":"5.35E-04"},0.00206466137235179,{"v":0.000961031791270468,"d":"9.61E-04"},"TLR4/NOS2/MAPK14/F2",4]
["GO:1904707","positive regulation of vascular smooth muscle cell proliferation","4/143","49/18670",{"v":0.000535037000888595,"d":"5.35E-04"},0.00206466137235179,{"v":0.000961031791270468,"d":"9.61E-04"},"MMP9/MMP2/TNF/FGF2",4]
["GO:0003158","endothelium development","6/143","132/18670",{"v":0.000539565042022285,"d":"5.40E-04"},0.00207817249296499,{"v":0.000967320772417137,"d":"9.67E-04"},"IKBKB/ALOX12/TNF/VEGFA/ICAM1/IL1B",6]
["GO:0045995","regulation of embryonic development","6/143","132/18670",{"v":0.000539565042022285,"d":"5.40E-04"},0.00207817249296499,{"v":0.000967320772417137,"d":"9.67E-04"},"AR/FGFR1/INSR/SHH/HNF4A/NFE2L2",6]
["GO:0042098","T cell proliferation","7/143","184/18670",{"v":0.000546010979343302,"d":"5.46E-04"},0.00210100042241605,{"v":0.000977946420877036,"d":"9.78E-04"},"PIK3CG/CASP3/IL2/SHH/IL6/TP53/IL1B",7]
["GO:0051781","positive regulation of cell division","5/143","87/18670",{"v":0.000548595450835078,"d":"5.49E-04"},0.00210894053654359,{"v":0.000981642282196021,"d":"9.82E-04"},"SHH/VEGFA/FGF2/PGF/IL1B",5]
["GO:0030198","extracellular matrix organization","10/143","368/18670",{"v":0.000549533723174037,"d":"5.50E-04"},0.00211054317970446,{"v":0.000982388259743859,"d":"9.82E-04"},"MMP9/MMP2/TNF/TTR/FGF2/SERPINE1/DPP4/IL6/ICAM1/CTRB1",10]
["GO:0034103","regulation of tissue remodeling","5/143","88/18670",{"v":0.000578101456279139,"d":"5.78E-04"},0.0022098894603838,0.00102863067768021,"VDR/IL2/IL6/TP53/MC4R",5]
["GO:0043506","regulation of JUN kinase activity","5/143","88/18670",{"v":0.000578101456279139,"d":"5.78E-04"},0.0022098894603838,0.00102863067768021,"TLR9/PTPN1/TNF/MAP3K9/PTPN22",5]
["GO:0002931","response to ischemia","4/143","50/18670",{"v":0.000578130666636968,"d":"5.78E-04"},0.0022098894603838,0.00102863067768021,"HK2/KCNJ11/CASR/TP53",4]
["GO:0014009","glial cell proliferation","4/143","50/18670",{"v":0.000578130666636968,"d":"5.78E-04"},0.0022098894603838,0.00102863067768021,"MTOR/TNF/IL6/IL1B",4]
["GO:0060425","lung morphogenesis","4/143","50/18670",{"v":0.000578130666636968,"d":"5.78E-04"},0.0022098894603838,0.00102863067768021,"MAPK1/MAPK3/SHH/TNF",4]
["GO:0018210","peptidyl-threonine modification","6/143","134/18670",{"v":0.000584214076791539,"d":"5.84E-04"},0.00223103639891712,0.00103847388029479,"GSK3B/MAPK1/MAPK8/PRKCB/MTOR/AKT1",6]
["GO:0060359","response to ammonium ion","6/143","135/18670",{"v":0.000607588104455331,"d":"6.08E-04"},0.00229955131633186,0.00107036531522624,"MAPK1/MTOR/MAPK3/HRH1/CNR1/CASP3",6]
["GO:0002052","positive regulation of neuroblast proliferation","3/143","22/18670",{"v":0.000608972087724248,"d":"6.09E-04"},0.00229955131633186,0.00107036531522624,"SHH/VEGFA/HIF1A",3]
["GO:0010226","response to lithium ion","3/143","22/18670",{"v":0.000608972087724248,"d":"6.09E-04"},0.00229955131633186,0.00107036531522624,"PTGS2/SHH/FABP4",3]
["GO:0010869","regulation of receptor biosynthetic process","3/143","22/18670",{"v":0.000608972087724248,"d":"6.09E-04"},0.00229955131633186,0.00107036531522624,"PPARG/PPARA/HIF1A",3]
["GO:0030878","thyroid gland development","3/143","22/18670",{"v":0.000608972087724248,"d":"6.09E-04"},0.00229955131633186,0.00107036531522624,"MAPK1/MAPK3/SHH",3]
["GO:0044321","response to leptin","3/143","22/18670",{"v":0.000608972087724248,"d":"6.09E-04"},0.00229955131633186,0.00107036531522624,"GCK/STAT3/SIRT1",3]
["GO:0045723","positive regulation of fatty acid biosynthetic process","3/143","22/18670",0.000608972087724248,0.00229955131633186,0.00107036531522624,"PTGS2/AVPR1A/IL1B",3]
["GO:0051000","positive regulation of nitric-oxide synthase activity","3/143","22/18670",0.000608972087724248,0.00229955131633186,0.00107036531522624,"AKT1/TNF/HIF1A",3]
["GO:0051195","negative regulation of cofactor metabolic process","3/143","22/18670",0.000608972087724248,0.00229955131633186,0.00107036531522624,"STAT3/PPARA/TP53",3]
["GO:0060065","uterus development","3/143","22/18670",0.000608972087724248,0.00229955131633186,0.00107036531522624,"CYP19A1/ESR1/RBP4",3]
["GO:0071379","cellular response to prostaglandin stimulus","3/143","22/18670",0.000608972087724248,0.00229955131633186,0.00107036531522624,"AKT1/PPARG/PRKAA2",3]
["GO:1903589","positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis","3/143","22/18670",0.000608972087724248,0.00229955131633186,0.00107036531522624,"VEGFA/HMOX1/AGTR1",3]
["GO:0007566","embryo implantation","4/143","51/18670",0.000623632759827526,0.00235052645417302,0.00109409256110092,"PTGS2/MMP9/MMP2/IL1B",4]
["GO:0045599","negative regulation of fat cell differentiation","4/143","51/18670",0.000623632759827526,0.00235052645417302,0.00109409256110092,"TNF/SIRT1/IL6/FOXO1",4]
["GO:0042475","odontogenesis of dentin-containing tooth","5/143","90/18670",0.000640669680422098,0.00241249382916154,0.00112293633092343,"PPARA/SHH/SERPINE1/FOXO1/GLI2",5]
["GO:0046425","regulation of JAK-STAT cascade","6/143","137/18670",0.000656510047983731,0.00246984449278638,0.00114963117383181,"F2/STAT3/IL2/AKR1B1/TNF/IL6",6]
["GO:2000179","positive regulation of neural precursor cell proliferation","4/143","52/18670",0.000671617807348695,0.00252433508277393,0.00117499474676652,"SHH/VEGFA/HIF1A/GLI2",4]
["GO:0014909","smooth muscle cell migration","5/143","91/18670",0.000673791668170111,0.00252781155954829,0.00117661293207599,"PLAT/SERPINE1/ACE/IGFBP3/NFE2L2",5]
["GO:0045639","positive regulation of myeloid cell differentiation","5/143","91/18670",0.000673791668170111,0.00252781155954829,0.00117661293207599,"MAPK14/STAT3/TNF/FOS/HIF1A",5]
["GO:0045926","negative regulation of growth","8/143","249/18670",0.000676919601232056,0.00253719494980311,0.00118098059084345,"PPARG/PPARA/HNF4A/SIRT1/HIF1A/ADRB2/TP53/RBP4",8]
["GO:0046631","alpha-beta T cell activation","6/143","138/18670",0.000682088353330115,0.00255420319544894,0.00118889736838298,"MTOR/STAT3/IL2/SHH/IL6/PRKCZ",6]
["GO:0034695","response to prostaglandin E","3/143","23/18670",0.000696404077638842,0.00259341647312054,0.00120714985616959,"AKT1/PPARG/PRKAA2",3]
["GO:0035812","renal sodium excretion","3/143","23/18670",0.000696404077638842,0.00259341647312054,0.00120714985616959,"AVPR2/AVPR1A/AGTR1",3]
["GO:0045821","positive regulation of glycolytic process","3/143","23/18670",0.000696404077638842,0.00259341647312054,0.00120714985616959,"INSR/HIF1A/PRKAA2",3]
["GO:0048714","positive regulation of oligodendrocyte differentiation","3/143","23/18670",0.000696404077638842,0.00259341647312054,0.00120714985616959,"MTOR/PPARG/SHH",3]
["GO:0060445","branching involved in salivary gland morphogenesis","3/143","23/18670",0.000696404077638842,0.00259341647312054,0.00120714985616959,"FGFR1/SHH/TNF",3]
["GO:1901889","negative regulation of cell junction assembly","3/143","23/18670",0.000696404077638842,0.00259341647312054,0.00120714985616959,"IKBKB/TNF/ACE",3]
["GO:0035710","CD4-positive, alpha-beta T cell activation","5/143","92/18670",0.000708179173047736,0.00263094764911807,0.00122461938109043,"MTOR/STAT3/IL2/IL6/PRKCZ",5]
["GO:0006720","isoprenoid metabolic process","6/143","139/18670",0.000708432049787227,0.00263094764911807,0.00122461938109043,"HMGCR/AKR1B1/TTR/CYP3A4/CYP26B1/RBP4",6]
["GO:0070665","positive regulation of leukocyte proliferation","6/143","139/18670",0.000708432049787227,0.00263094764911807,0.00122461938109043,"TLR4/TLR9/IL2/SHH/IL6/IL1B",6]
["GO:0042176","regulation of protein catabolic process","10/143","381/18670",0.000718039716710871,0.00266418402680624,0.00124008981900956,"GSK3B/NOS2/HMGCR/AKT1/SHH/TNF/FOXO1/OGT/NFE2L2/IL1B",10]
["GO:0007632","visual behavior","4/143","53/18670",0.000722160529931701,0.00267212598278202,0.00124378653764817,"HMGCR/MTOR/HRH1/HIF1A",4]
["GO:0032715","negative regulation of interleukin-6 production","4/143","53/18670",0.000722160529931701,0.00267212598278202,0.00124378653764817,"TLR4/TLR9/TNF/PTPN22",4]
["GO:0038066","p38MAPK cascade","4/143","53/18670",0.000722160529931701,0.00267212598278202,0.00124378653764817,"MAPK14/VEGFA/PTPN22/IL1B",4]
["GO:0051961","negative regulation of nervous system development","9/143","315/18670",0.000730603308858625,0.0027008969810591,0.00125717848868728,"GSK3B/F2/STAT3/SHH/TNF/IL6/EIF2AK3/TP53/IL1B",9]
["GO:0033273","response to vitamin","5/143","93/18670",0.000743862700408292,0.00274490083067709,0.0012776608297566,"PTGS2/VDR/PPARG/CASR/CYP26B1",5]
["GO:0036473","cell death in response to oxidative stress","5/143","93/18670",0.000743862700408292,0.00274490083067709,0.0012776608297566,"TLR4/AKT1/SIRT1/HIF1A/NFE2L2",5]
["GO:0051271","negative regulation of cellular component movement","10/143","384/18670",0.000762441805065653,0.00281089656366645,0.00130837966740247,"STAT3/AKT1/CYP19A1/PPARG/SHH/FGF2/SERPINE1/IGFBP3/HMOX1/NFE2L2",10]
["GO:0050709","negative regulation of protein secretion","6/143","141/18670",0.000763477982225732,0.00281215547957212,0.00130896565124665,"HMGCR/MTNR1B/TNF/KCNJ11/PTPN22/IL1B",6]
["GO:0044062","regulation of excretion","3/143","24/18670",0.000791443974926126,0.00289933503212756,0.00134954485841178,"AVPR2/AVPR1A/AGTR1",3]
["GO:0046835","carbohydrate phosphorylation","3/143","24/18670",0.000791443974926126,0.00289933503212756,0.00134954485841178,"GCK/HK2/HK1",3]
["GO:0050996","positive regulation of lipid catabolic process","3/143","24/18670",0.000791443974926126,0.00289933503212756,0.00134954485841178,"PPARA/AKT2/IL1B",3]
["GO:0060396","growth hormone receptor signaling pathway","3/143","24/18670",0.000791443974926126,0.00289933503212756,0.00134954485841178,"STAT3/PIK3R1/PTPN1",3]
["GO:1905564","positive regulation of vascular endothelial cell proliferation","3/143","24/18670",0.000791443974926126,0.00289933503212756,0.00134954485841178,"FGFR1/STAT3/FGF2",3]
["GO:2001026","regulation of endothelial cell chemotaxis","3/143","24/18670",0.000791443974926126,0.00289933503212756,0.00134954485841178,"FGFR1/VEGFA/FGF2",3]
["GO:1903076","regulation of protein localization to plasma membrane","5/143","95/18670",0.000819241017737737,0.00299845175389002,0.00139568042424151,"AR/AKT1/PIK3R1/TNF/KCNJ11",5]
["GO:0048016","inositol phosphate-mediated signaling","4/143","55/18670",0.000831218642487315,0.00303954206394639,0.0014148066087123,"GSK3B/MTOR/HRH1/TNF",4]
["GO:1902107","positive regulation of leukocyte differentiation","6/143","144/18670",0.000852180792013011,0.00311338253255295,0.00144917691212549,"IL2/SHH/TNF/FOS/PRKCZ/GLI2",6]
["GO:0003007","heart morphogenesis","8/143","259/18670",0.000874114249493029,0.00319063524071035,0.00148513550053868,"MTOR/INSR/NOS3/SHH/VEGFA/HIF1A/TP53/RBP4",8]
["GO:1903078","positive regulation of protein localization to plasma membrane","4/143","56/18670",0.00088988413117992,0.00322953629498978,0.00150324265863109,"AKT1/PIK3R1/TNF/KCNJ11",4]
["GO:1903202","negative regulation of oxidative stress-induced cell death","4/143","56/18670",0.00088988413117992,0.00322953629498978,0.00150324265863109,"AKT1/SIRT1/HIF1A/NFE2L2",4]
["GO:0002053","positive regulation of mesenchymal cell proliferation","3/143","25/18670",0.000894345401848703,0.00322953629498978,0.00150324265863109,"FGFR1/SHH/VEGFA",3]
["GO:0009299","mRNA transcription","3/143","25/18670",0.000894345401848703,0.00322953629498978,0.00150324265863109,"STAT3/HIF1A/TP53",3]
["GO:0019430","removal of superoxide radicals","3/143","25/18670",0.000894345401848703,0.00322953629498978,0.00150324265863109,"NOS3/TNF/NFE2L2",3]
["GO:0030813","positive regulation of nucleotide catabolic process","3/143","25/18670",0.000894345401848703,0.00322953629498978,0.00150324265863109,"INSR/HIF1A/PRKAA2",3]
["GO:0050901","leukocyte tethering or rolling","3/143","25/18670",0.000894345401848703,0.00322953629498978,0.00150324265863109,"SELP/TNF/SELL",3]
["GO:0050927","positive regulation of positive chemotaxis","3/143","25/18670",0.000894345401848703,0.00322953629498978,0.00150324265863109,"VEGFA/PGF/CASR",3]
["GO:0051197","positive regulation of coenzyme metabolic process","3/143","25/18670",0.000894345401848703,0.00322953629498978,0.00150324265863109,"INSR/HIF1A/PRKAA2",3]
["GO:0060444","branching involved in mammary gland duct morphogenesis","3/143","25/18670",0.000894345401848703,0.00322953629498978,0.00150324265863109,"AR/ESR1/VDR",3]
["GO:0061050","regulation of cell growth involved in cardiac muscle cell development","3/143","25/18670",0.000894345401848703,0.00322953629498978,0.00150324265863109,"MTOR/PPARA/PARP2",3]
["GO:0071378","cellular response to growth hormone stimulus","3/143","25/18670",0.000894345401848703,0.00322953629498978,0.00150324265863109,"STAT3/PIK3R1/PTPN1",3]
["GO:0072659","protein localization to plasma membrane","8/143","260/18670",0.000896132833896843,0.00323310669484351,0.0015049045620371,"AR/AKT1/PIK3R1/IKBKB/TNF/AKT2/KCNJ11/PRKCZ",8]
["GO:0001657","ureteric bud development","5/143","97/18670",0.000900175262108906,0.00324191233186553,0.0015090032957248,"FGFR1/SHH/VEGFA/FGF2/PGF",5]
["GO:0051591","response to cAMP","5/143","97/18670",0.000900175262108906,0.00324191233186553,0.0015090032957248,"PIK3CG/REN/KCNQ1/CFTR/FOS",5]
["GO:0042542","response to hydrogen peroxide","6/143","146/18670",0.000915593254801679,0.00329158214514849,0.00153212295605778,"CASP3/SIRT1/HMOX1/IL6/FOXO1/NFE2L2",6]
["GO:1904892","regulation of STAT cascade","6/143","146/18670",0.000915593254801679,0.00329158214514849,0.00153212295605778,"F2/STAT3/IL2/AKR1B1/TNF/IL6",6]
["GO:0002703","regulation of leukocyte mediated immunity","7/143","201/18670",0.000919400641497444,0.00330233699803164,0.00153712898545783,"TLR4/IL2/TNF/HMOX1/IL6/PRKCZ/IL1B",7]
["GO:0002042","cell migration involved in sprouting angiogenesis","5/143","98/18670",0.000942804506518818,0.00337740941804263,0.00157207272162896,"PTGS2/AKT1/VEGFA/FGF2/HMOX1",5]
["GO:0072163","mesonephric epithelium development","5/143","98/18670",0.000942804506518818,0.00337740941804263,0.00157207272162896,"FGFR1/SHH/VEGFA/FGF2/PGF",5]
["GO:0072164","mesonephric tubule development","5/143","98/18670",0.000942804506518818,0.00337740941804263,0.00157207272162896,"FGFR1/SHH/VEGFA/FGF2/PGF",5]
["GO:0061351","neural precursor cell proliferation","6/143","147/18670",0.000948631809213021,0.00339228053329886,0.00157899473543919,"FGFR1/SHH/VEGFA/FOXO1/HIF1A/TP53",6]
["GO:0071236","cellular response to antibiotic","6/143","147/18670",0.000948631809213021,0.00339228053329886,0.00157899473543919,"CFTR/SIRT1/IL6/FOXO1/TP53/NFE2L2",6]
["GO:0002066","columnar/cuboidal epithelial cell development","4/143","57/18670",0.00095140742628684,0.00339321344635166,0.00157942897570456,"GSK3B/FGFR1/HNF4A/HIF1A",4]
["GO:0033344","cholesterol efflux","4/143","57/18670",0.00095140742628684,0.00339321344635166,0.00157942897570456,"PON1/SHH/SIRT1/CETP",4]
["GO:1900408","negative regulation of cellular response to oxidative stress","4/143","57/18670",0.00095140742628684,0.00339321344635166,0.00157942897570456,"AKT1/SIRT1/HIF1A/NFE2L2",4]
["GO:0043254","regulation of protein complex assembly","11/143","467/18670",0.000952323438539843,0.00339349056268423,0.00157955796422009,"GSK3B/TLR4/SELP/MTOR/ESR1/TNF/VEGFA/PRKCZ/TP53/ICAM1/PRKAA2",11]
["GO:0040013","negative regulation of locomotion","10/143","396/18670",0.000963331531301426,0.00342969748347245,0.00159641109200533,"STAT3/AKT1/CYP19A1/PPARG/SHH/FGF2/SERPINE1/IGFBP3/HMOX1/NFE2L2",10]
["GO:0030278","regulation of ossification","7/143","203/18670",0.000974046380045709,0.0034647976682118,0.00161274907065195,"MAPK14/MAPK1/MAPK3/TNF/IL6/HIF1A/ADRB2",7]
["GO:0002792","negative regulation of peptide secretion","6/143","148/18670",0.000982580728686121,0.00349208673373259,0.00162545123085639,"HMGCR/MTNR1B/TNF/KCNJ11/PTPN22/IL1B",6]
["GO:0001708","cell fate specification","5/143","99/18670",0.000986917523919942,0.00350135156601922,0.00162976370479883,"AR/FGFR1/SHH/FGF2/GLI2",5]
["GO:1901570","fatty acid derivative biosynthetic process","5/143","99/18670",0.000986917523919942,0.00350135156601922,0.00162976370479883,"PTGS2/ALOX12/AVPR1A/SIRT1/IL1B",5]
["GO:0006473","protein acetylation","7/143","204/18670",0.00100231212523183,0.00354192930546738,0.00164865130455237,"GSK3B/MAPK3/SIRT1/FOXO1/OGT/PRKAA2/IL1B",7]
["GO:0003081","regulation of systemic arterial blood pressure by renin-angiotensin","3/143","26/18670",0.00100535493379002,0.00354192930546738,0.00164865130455237,"REN/ACE/AGTR1",3]
["GO:0010758","regulation of macrophage chemotaxis","3/143","26/18670",0.00100535493379002,0.00354192930546738,0.00164865130455237,"MAPK14/MAPK3/CYP19A1",3]
["GO:0031645","negative regulation of neurological system process","3/143","26/18670",0.00100535493379002,0.00354192930546738,0.00164865130455237,"MTNR1B/AVPR1A/EIF2AK3",3]
["GO:0050926","regulation of positive chemotaxis","3/143","26/18670",0.00100535493379002,0.00354192930546738,0.00164865130455237,"VEGFA/PGF/CASR",3]
["GO:0072539","T-helper 17 cell differentiation","3/143","26/18670",0.00100535493379002,0.00354192930546738,0.00164865130455237,"STAT3/IL2/IL6",3]
["GO:1903579","negative regulation of ATP metabolic process","3/143","26/18670",0.00100535493379002,0.00354192930546738,0.00164865130455237,"STAT3/PPARA/TP53",3]
["GO:1905048","regulation of metallopeptidase activity","3/143","26/18670",0.00100535493379002,0.00354192930546738,0.00164865130455237,"MAPK14/MAPK3/STAT3",3]
["GO:0055081","anion homeostasis","4/143","58/18670",0.00101586370750695,0.00357273352561959,0.00166298965333344,"HNF4A/SIRT1/PRKAA2/CETP",4]
["GO:1902041","regulation of extrinsic apoptotic signaling pathway via death domain receptors","4/143","58/18670",0.00101586370750695,0.00357273352561959,0.00166298965333344,"NOS3/SERPINE1/HMOX1/ICAM1",4]
["GO:0002824","positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains","5/143","100/18670",0.0010325463281539,0.00362510627612053,0.00168736744181812,"IL2/TNF/IL6/PRKCZ/IL1B",5]
["GO:0007200","phospholipase C-activating G protein-coupled receptor signaling pathway","5/143","100/18670",0.0010325463281539,0.00362510627612053,0.00168736744181812,"F2/HRH1/ESR1/AGTR1/CASR",5]
["GO:0001658","branching involved in ureteric bud morphogenesis","4/143","59/18670",0.00108332815001012,0.00378370349546244,0.00176118921803562,"SHH/VEGFA/FGF2/PGF",4]
["GO:0010656","negative regulation of muscle cell apoptotic process","4/143","59/18670",0.00108332815001012,0.00378370349546244,0.00176118921803562,"HMGCR/ALOX12/HMOX1/NFE2L2",4]
["GO:0032890","regulation of organic acid transport","4/143","59/18670",0.00108332815001012,0.00378370349546244,0.00176118921803562,"AKT1/AVPR1A/AKT2/IL1B",4]
["GO:1902883","negative regulation of response to oxidative stress","4/143","59/18670",0.00108332815001012,0.00378370349546244,0.00176118921803562,"AKT1/SIRT1/HIF1A/NFE2L2",4]
["GO:2000351","regulation of endothelial cell apoptotic process","4/143","59/18670",0.00108332815001012,0.00378370349546244,0.00176118921803562,"TNF/SERPINE1/ICAM1/NFE2L2",4]
["GO:2000756","regulation of peptidyl-lysine acetylation","4/143","59/18670",0.00108332815001012,0.00378370349546244,0.00176118921803562,"MAPK3/SIRT1/PRKAA2/IL1B",4]
["GO:0031334","positive regulation of protein complex assembly","8/143","268/18670",0.00108879104089843,0.00379950528754901,0.00176854443122341,"GSK3B/TLR4/MTOR/ESR1/TNF/VEGFA/TP53/ICAM1",8]
["GO:0055088","lipid homeostasis","6/143","151/18670",{"v":0.00109005804101577,"d":"1.09E-03"},{"v":0.00380065025842537,"d":"3.80E-03"},{"v":0.00176907737741351,"d":"1.77E-03"},"PPARG/FABP4/HNF4A/SIRT1/PRKAA2/CETP",6]
["GO:0009651","response to salt stress","3/143","27/18670",{"v":0.00112471221105326,"d":"1.12E-03"},{"v":0.00389464074451976,"d":"3.89E-03"},{"v":0.00181282684956583,"d":"1.81E-03"},"AKR1B1/TNF/TP53",3]
["GO:0035902","response to immobilization stress","3/143","27/18670",{"v":0.00112471221105326,"d":"1.12E-03"},{"v":0.00389464074451976,"d":"3.89E-03"},{"v":0.00181282684956583,"d":"1.81E-03"},"REN/PPARG/FOS",3]
["GO:0045932","negative regulation of muscle contraction","3/143","27/18670",{"v":0.00112471221105326,"d":"1.12E-03"},{"v":0.00389464074451976,"d":"3.89E-03"},{"v":0.00181282684956583,"d":"1.81E-03"},"PTGS2/PIK3CG/ADRB2",3]
["GO:0048643","positive regulation of skeletal muscle tissue development","3/143","27/18670",{"v":0.00112471221105326,"d":"1.12E-03"},{"v":0.00389464074451976,"d":"3.89E-03"},{"v":0.00181282684956583,"d":"1.81E-03"},"HMGCR/SHH/CYP26B1",3]
["GO:0071450","cellular response to oxygen radical","3/143","27/18670",{"v":0.00112471221105326,"d":"1.12E-03"},{"v":0.00389464074451976,"d":"3.89E-03"},{"v":0.00181282684956583,"d":"1.81E-03"},"NOS3/TNF/NFE2L2",3]
["GO:0071451","cellular response to superoxide","3/143","27/18670",{"v":0.00112471221105326,"d":"1.12E-03"},{"v":0.00389464074451976,"d":"3.89E-03"},{"v":0.00181282684956583,"d":"1.81E-03"},"NOS3/TNF/NFE2L2",3]
["GO:0071514","genetic imprinting","3/143","27/18670",{"v":0.00112471221105326,"d":"1.12E-03"},{"v":0.00389464074451976,"d":"3.89E-03"},{"v":0.00181282684956583,"d":"1.81E-03"},"PIK3CA/KCNQ1/PRMT7",3]
["GO:2000191","regulation of fatty acid transport","3/143","27/18670",{"v":0.00112471221105326,"d":"1.12E-03"},{"v":0.00389464074451976,"d":"3.89E-03"},{"v":0.00181282684956583,"d":"1.81E-03"},"AKT1/AKT2/IL1B",3]
["GO:0098869","cellular oxidant detoxification","5/143","102/18670",{"v":0.00112848028472244,"d":"1.13E-03"},{"v":0.00390434888252685,"d":"3.90E-03"},{"v":0.00181734566770415,"d":"1.82E-03"},"PTGS2/NOS3/TNF/GSR/NFE2L2",5]
["GO:0051216","cartilage development","7/143","209/18670",{"v":0.00115347691638058,"d":"1.15E-03"},{"v":0.00398742489966576,"d":"3.99E-03"},{"v":0.00185601481443772,"d":"1.86E-03"},"MAPK14/FGFR1/MAPK3/FGF2/HIF1A/EIF2AK3/GLI2",7]
["GO:0055067","monovalent inorganic cation homeostasis","6/143","154/18670",{"v":0.00120633997227088,"d":"1.21E-03"},{"v":0.00416660768579568,"d":"4.17E-03"},{"v":0.00193941849323233,"d":"1.94E-03"},"MAPK1/MAPK3/AVPR2/AVPR1A/CFTR/AGTR1",6]
["GO:0030888","regulation of B cell proliferation","4/143","61/18670",{"v":0.00122758201609541,"d":"1.23E-03"},{"v":0.0042296655754223,"d":"4.23E-03"},{"v":0.00196876986166162,"d":"1.97E-03"},"TLR4/TLR9/CASP3/IL2",4]
["GO:0032370","positive regulation of lipid transport","4/143","61/18670",{"v":0.00122758201609541,"d":"1.23E-03"},{"v":0.0042296655754223,"d":"4.23E-03"},{"v":0.00196876986166162,"d":"1.97E-03"},"CYP19A1/PON1/SIRT1/IL1B",4]
["GO:0001523","retinoid metabolic process","5/143","104/18670",{"v":0.00123086611853939,"d":"1.23E-03"},{"v":0.0042296655754223,"d":"4.23E-03"},{"v":0.00196876986166162,"d":"1.97E-03"},"AKR1B1/TTR/CYP3A4/CYP26B1/RBP4",5]
["GO:0008630","intrinsic apoptotic signaling pathway in response to DNA damage","5/143","104/18670",{"v":0.00123086611853939,"d":"1.23E-03"},{"v":0.0042296655754223,"d":"4.23E-03"},{"v":0.00196876986166162,"d":"1.97E-03"},"PIK3R1/TNF/SIRT1/HMOX1/TP53",5]
["GO:0014812","muscle cell migration","5/143","104/18670",{"v":0.00123086611853939,"d":"1.23E-03"},{"v":0.0042296655754223,"d":"4.23E-03"},{"v":0.00196876986166162,"d":"1.97E-03"},"PLAT/SERPINE1/ACE/IGFBP3/NFE2L2",5]
["GO:0019233","sensory perception of pain","5/143","104/18670",{"v":0.00123086611853939,"d":"1.23E-03"},{"v":0.0042296655754223,"d":"4.23E-03"},{"v":0.00196876986166162,"d":"1.97E-03"},"PTGS2/MAPK1/MTOR/MAPK3/CNR1",5]
["GO:0006972","hyperosmotic response","3/143","28/18670",{"v":0.00125265004923905,"d":"1.25E-03"},{"v":0.00427548684596938,"d":"4.28E-03"},{"v":0.00199009815224807,"d":"1.99E-03"},"MAPK10/SLC2A1/AKR1B1",3]
["GO:0042730","fibrinolysis","3/143","28/18670",{"v":0.00125265004923905,"d":"1.25E-03"},{"v":0.00427548684596938,"d":"4.28E-03"},{"v":0.00199009815224807,"d":"1.99E-03"},"F2/PLAT/SERPINE1",3]
["GO:0045408","regulation of interleukin-6 biosynthetic process","3/143","28/18670",{"v":0.00125265004923905,"d":"1.25E-03"},{"v":0.00427548684596938,"d":"4.28E-03"},{"v":0.00199009815224807,"d":"1.99E-03"},"STAT3/TNF/IL1B",3]
["GO:1900543","negative regulation of purine nucleotide metabolic process","3/143","28/18670",{"v":0.00125265004923905,"d":"1.25E-03"},{"v":0.00427548684596938,"d":"4.28E-03"},{"v":0.00199009815224807,"d":"1.99E-03"},"STAT3/PPARA/TP53",3]
["GO:1902932","positive regulation of alcohol biosynthetic process","3/143","28/18670",{"v":0.00125265004923905,"d":"1.25E-03"},{"v":0.00427548684596938,"d":"4.28E-03"},{"v":0.00199009815224807,"d":"1.99E-03"},"HRH1/TNF/IL1B",3]
["GO:1903792","negative regulation of anion transport","3/143","28/18670",{"v":0.00125265004923905,"d":"1.25E-03"},{"v":0.00427548684596938,"d":"4.28E-03"},{"v":0.00199009815224807,"d":"1.99E-03"},"MTOR/AKT1/AKT2",3]
["GO:1990776","response to angiotensin","3/143","28/18670",{"v":0.00125265004923905,"d":"1.25E-03"},{"v":0.00427548684596938,"d":"4.28E-03"},{"v":0.00199009815224807,"d":"1.99E-03"},"PTGS2/AGTR1/NFE2L2",3]
["GO:2000108","positive regulation of leukocyte apoptotic process","3/143","28/18670",{"v":0.00125265004923905,"d":"1.25E-03"},{"v":0.00427548684596938,"d":"4.28E-03"},{"v":0.00199009815224807,"d":"1.99E-03"},"SIRT1/TP53/HCAR2",3]
["GO:0002708","positive regulation of lymphocyte mediated immunity","5/143","105/18670",{"v":0.00128456039546789,"d":"1.28E-03"},{"v":0.00438070807148613,"d":"4.38E-03"},{"v":0.00203907516329316,"d":"2.04E-03"},"IL2/TNF/IL6/PRKCZ/IL1B",5]
["GO:0034767","positive regulation of ion transmembrane transport","6/143","156/18670",{"v":0.00128898413633069,"d":"1.29E-03"},{"v":0.00439209409416383,"d":"4.39E-03"},{"v":0.00204437498142117,"d":"2.04E-03"},"F2/KCNQ1/CFTR/KCNJ11/ADRB2/ATP2A1",6]
["GO:0033044","regulation of chromosome organization","9/143","342/18670",{"v":0.00129968836882894,"d":"1.30E-03"},{"v":0.00442112480421811,"d":"4.42E-03"},{"v":0.00205788781972915,"d":"2.06E-03"},"MAPK1/MAPK8/MAPK3/VEGFA/SIRT1/SETD7/OGT/TP53/IL1B",9]
["GO:1904062","regulation of cation transmembrane transport","9/143","342/18670",{"v":0.00129968836882894,"d":"1.30E-03"},{"v":0.00442112480421811,"d":"4.42E-03"},{"v":0.00205788781972915,"d":"2.06E-03"},"MMP9/TLR9/PIK3CG/F2/MTNR1B/KCNQ1/KCNJ11/ADRB2/ATP2A1",9]
["GO:0002260","lymphocyte homeostasis","4/143","62/18670",{"v":0.00130452149882936,"d":"1.30E-03"},{"v":0.00443383965345193,"d":"4.43E-03"},{"v":0.00206380616280397,"d":"2.06E-03"},"AKT1/CASP3/IL2/HIF1A",4]
["GO:0007588","excretion","4/143","63/18670",{"v":0.00138476920439979,"d":"1.38E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"AVPR2/AVPR1A/HMOX1/AGTR1",4]
["GO:0031646","positive regulation of neurological system process","4/143","63/18670",{"v":0.00138476920439979,"d":"1.38E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"MTOR/MTNR1B/PRKCZ/ADRB2",4]
["GO:1904377","positive regulation of protein localization to cell periphery","4/143","63/18670",{"v":0.00138476920439979,"d":"1.38E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"AKT1/PIK3R1/TNF/KCNJ11",4]
["GO:0000303","response to superoxide","3/143","29/18670",{"v":0.00138939454821815,"d":"1.39E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"NOS3/TNF/NFE2L2",3]
["GO:0007263","nitric oxide mediated signal transduction","3/143","29/18670",{"v":0.00138939454821815,"d":"1.39E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"NOS2/NOS3/VEGFA",3]
["GO:0010669","epithelial structure maintenance","3/143","29/18670",{"v":0.00138939454821815,"d":"1.39E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"TLR4/TLR9/RBP4",3]
["GO:0031063","regulation of histone deacetylation","3/143","29/18670",{"v":0.00138939454821815,"d":"1.39E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"MAPK8/VEGFA/TP53",3]
["GO:0033032","regulation of myeloid cell apoptotic process","3/143","29/18670",{"v":0.00138939454821815,"d":"1.39E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"SIRT1/CCR5/HCAR2",3]
["GO:0042226","interleukin-6 biosynthetic process","3/143","29/18670",{"v":0.00138939454821815,"d":"1.39E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"STAT3/TNF/IL1B",3]
["GO:0045980","negative regulation of nucleotide metabolic process","3/143","29/18670",{"v":0.00138939454821815,"d":"1.39E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"STAT3/PPARA/TP53",3]
["GO:0050855","regulation of B cell receptor signaling pathway","3/143","29/18670",{"v":0.00138939454821815,"d":"1.39E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"PRKCB/BLK/PTPN22",3]
["GO:0072538","T-helper 17 type immune response","3/143","29/18670",{"v":0.00138939454821815,"d":"1.39E-03"},{"v":0.00467520293531761,"d":"4.68E-03"},{"v":0.00217615281210176,"d":"2.18E-03"},"STAT3/IL2/IL6",3]
["GO:0043502","regulation of muscle adaptation","5/143","107/18670",{"v":0.00139711684504014,"d":"1.40E-03"},{"v":0.00469728321322467,"d":"4.70E-03"},{"v":0.00218643045342005,"d":"2.19E-03"},"MTOR/NOS3/PPARA/FOXO1/PARP2",5]
["GO:2000278","regulation of DNA biosynthetic process","5/143","108/18670",{"v":0.00145604552209732,"d":"1.46E-03"},{"v":0.00489134628502071,"d":"4.89E-03"},{"v":0.00227676041454833,"d":"2.28E-03"},"MAPK1/MAPK3/PPARG/FGF2/TP53",5]
["GO:0002819","regulation of adaptive immune response","6/143","160/18670",{"v":0.00146720469685538,"d":"1.47E-03"},{"v":0.00490840840518929,"d":"4.91E-03"},{"v":0.00228470226890182,"d":"2.28E-03"},"IL2/TNF/SIRT1/IL6/PRKCZ/IL1B",6]
["GO:0046661","male sex differentiation","6/143","160/18670",{"v":0.00146720469685538,"d":"1.47E-03"},{"v":0.00490840840518929,"d":"4.91E-03"},{"v":0.00228470226890182,"d":"2.28E-03"},"AR/REN/INSR/ESR1/SHH/ICAM1",6]
["GO:0043550","regulation of lipid kinase activity","4/143","64/18670",{"v":0.0014683998465129,"d":"1.47E-03"},0.00490840840518929,{"v":0.00228470226890182,"d":"2.28E-03"},"FLT1/F2/PIK3R1/FGF2",4]
["GO:0045600","positive regulation of fat cell differentiation","4/143","64/18670",{"v":0.0014683998465129,"d":"1.47E-03"},0.00490840840518929,{"v":0.00228470226890182,"d":"2.28E-03"},"MAPK14/PTGS2/AKT1/PPARG",4]
["GO:0046503","glycerolipid catabolic process","4/143","64/18670",{"v":0.0014683998465129,"d":"1.47E-03"},0.00490840840518929,{"v":0.00228470226890182,"d":"2.28E-03"},"PIK3CG/FABP4/FABP2/LIPE",4]
["GO:2000378","negative regulation of reactive oxygen species metabolic process","4/143","64/18670",{"v":0.0014683998465129,"d":"1.47E-03"},0.00490840840518929,{"v":0.00228470226890182,"d":"2.28E-03"},"STAT3/HK2/HIF1A/TP53",4]
["GO:0006814","sodium ion transport","7/143","218/18670",{"v":0.00147019635768314,"d":"1.47E-03"},0.00491035879199781,{"v":0.00228561010965157,"d":"2.29E-03"},"AKT1/NOS3/SLC5A2/SGK1/SLC5A1/ADRB2/SLC5A4",7]
["GO:0007178","transmembrane receptor protein serine/threonine kinase signaling pathway","9/143","349/18670",{"v":0.0014944010597347,"d":"1.49E-03"},0.0049870861416373,{"v":0.00232132416099718,"d":"2.32E-03"},"MAPK14/MAPK3/LNPEP/SHH/FOS/HNF4A/SIRT1/PRKCZ/TP53",9]
["GO:0001676","long-chain fatty acid metabolic process","5/143","109/18670",{"v":0.00151678572860843,"d":"1.52E-03"},0.00505761831087885,{"v":0.00235415456013968,"d":"2.35E-03"},"PTGS2/MAPK3/ALOX12/CYP3A4/LIPE",5]
["GO:0000305","response to oxygen radical","3/143","30/18670",{"v":0.00153516519971468,"d":"1.54E-03"},0.00510209255208949,{"v":0.00237485585298528,"d":"2.37E-03"},"NOS3/TNF/NFE2L2",3]
["GO:0042759","long-chain fatty acid biosynthetic process","3/143","30/18670",{"v":0.00153516519971468,"d":"1.54E-03"},0.00510209255208949,{"v":0.00237485585298528,"d":"2.37E-03"},"PTGS2/ALOX12/CYP3A4",3]
["GO:0045940","positive regulation of steroid metabolic process","3/143","30/18670",{"v":0.00153516519971468,"d":"1.54E-03"},0.00510209255208949,{"v":0.00237485585298528,"d":"2.37E-03"},"TNF/AGTR1/IL1B",3]
["GO:0061082","myeloid leukocyte cytokine production","3/143","30/18670",{"v":0.00153516519971468,"d":"1.54E-03"},0.00510209255208949,{"v":0.00237485585298528,"d":"2.37E-03"},"TLR4/SIRT1/HMOX1",3]
["GO:0060675","ureteric bud morphogenesis","4/143","65/18670",{"v":0.00155548796399463,"d":"1.56E-03"},0.00516116006413957,{"v":0.0024023498322264,"d":"2.40E-03"},"SHH/VEGFA/FGF2/PGF",4]
["GO:0072577","endothelial cell apoptotic process","4/143","65/18670",{"v":0.00155548796399463,"d":"1.56E-03"},0.00516116006413957,0.0024023498322264,"TNF/SERPINE1/ICAM1/NFE2L2",4]
["GO:0021700","developmental maturation","8/143","284/18670",{"v":0.00157313497837235,"d":"1.57E-03"},0.00521543848685608,0.00242761464829218,"FGFR1/REN/MTOR/PPARG/MMP2/CFTR/VEGFA/HIF1A",8]
["GO:0016101","diterpenoid metabolic process","5/143","110/18670",{"v":0.00157937104388876,"d":"1.58E-03"},0.00523182813883935,0.00243524349087852,"AKR1B1/TTR/CYP3A4/CYP26B1/RBP4",5]
["GO:0002446","neutrophil mediated immunity","11/143","499/18670",{"v":0.00161710487771322,"d":"1.62E-03"},0.00535244525346125,0.00249138678065728,"MAPK14/MAPK1/MMP9/F2/MGAM/TTR/IMPDH2/AGPAT2/ACE/IL6/SELL",11]
["GO:0040014","regulation of multicellular organism growth","4/143","66/18670",{"v":0.00164610789492904,"d":"1.65E-03"},0.00543068032491667,0.00252780262679448,"PIK3CA/STAT3/ADRB2/FTO",4]
["GO:0046888","negative regulation of hormone secretion","4/143","66/18670",{"v":0.00164610789492904,"d":"1.65E-03"},0.00543068032491667,0.00252780262679448,"HMGCR/MTNR1B/KCNJ11/IL1B",4]
["GO:0051926","negative regulation of calcium ion transport","4/143","66/18670",{"v":0.00164610789492904,"d":"1.65E-03"},0.00543068032491667,0.00252780262679448,"PTGS2/TLR9/NOS3/ICAM1",4]
["GO:0072171","mesonephric tubule morphogenesis","4/143","66/18670",{"v":0.00164610789492904,"d":"1.65E-03"},0.00543068032491667,0.00252780262679448,"SHH/VEGFA/FGF2/PGF",4]
["GO:0002724","regulation of T cell cytokine production","3/143","31/18670",{"v":0.00169017499351558,"d":"1.69E-03"},0.00554892812145262,0.00258284307712715,"IL6/PRKCZ/IL1B",3]
["GO:0033198","response to ATP","3/143","31/18670",{"v":0.00169017499351558,"d":"1.69E-03"},0.00554892812145262,0.00258284307712715,"PTGS2/KCNJ11/IL1B",3]
["GO:0034694","response to prostaglandin","3/143","31/18670",0.00169017499351558,0.00554892812145262,0.00258284307712715,"AKT1/PPARG/PRKAA2",3]
["GO:0035767","endothelial cell chemotaxis","3/143","31/18670",0.00169017499351558,0.00554892812145262,0.00258284307712715,"FGFR1/VEGFA/FGF2",3]
["GO:0043457","regulation of cellular respiration","3/143","31/18670",0.00169017499351558,0.00554892812145262,0.00258284307712715,"NOS2/PIK3CA/HIF1A",3]
["GO:0045648","positive regulation of erythrocyte differentiation","3/143","31/18670",0.00169017499351558,0.00554892812145262,0.00258284307712715,"MAPK14/STAT3/HIF1A",3]
["GO:0002065","columnar/cuboidal epithelial cell differentiation","5/143","112/18670",0.00171021190311592,0.00559655439273504,0.00260501153604008,"GSK3B/FGFR1/SERPINE1/HNF4A/HIF1A",5]
["GO:0014902","myotube differentiation","5/143","112/18670",0.00171021190311592,0.00559655439273504,0.00260501153604008,"MAPK14/MTOR/AVPR1A/SHH/CYP26B1",5]
["GO:0043279","response to alkaloid","5/143","112/18670",0.00171021190311592,0.00559655439273504,0.00260501153604008,"MTOR/CNR1/PPARG/CASP3/ICAM1",5]
["GO:1990748","cellular detoxification","5/143","112/18670",0.00171021190311592,0.00559655439273504,0.00260501153604008,"PTGS2/NOS3/TNF/GSR/NFE2L2",5]
["GO:0043200","response to amino acid","5/143","113/18670",0.00177853517014033,0.00581543648524077,0.0027068939329574,"MTOR/MMP2/CASP3/TNF/ICAM1",5]
["GO:0035051","cardiocyte differentiation","6/143","167/18670",0.00182360725410854,0.00595800013287438,0.00277325261021561,"MAPK1/MTOR/MAPK3/PPARA/VEGFA/PARP2",6]
["GO:0033627","cell adhesion mediated by integrin","4/143","68/18670",0.0018382393954335,0.00599129877030176,0.00278875202799047,"PIK3CG/SERPINE1/DPP4/ICAM1",4]
["GO:0050918","positive chemotaxis","4/143","68/18670",0.0018382393954335,0.00599129877030176,0.00278875202799047,"VEGFA/FGF2/PGF/CASR",4]
["GO:0071242","cellular response to ammonium ion","4/143","68/18670",0.0018382393954335,0.00599129877030176,0.00278875202799047,"MAPK1/MAPK3/HRH1/CASP3",4]
["GO:0030218","erythrocyte differentiation","5/143","114/18670",0.00184883897836793,0.00601615770452845,0.00280032304220562,"MAPK14/STAT3/CASP3/VEGFA/HIF1A",5]
["GO:0045446","endothelial cell differentiation","5/143","114/18670",0.00184883897836793,0.00601615770452845,0.00280032304220562,"IKBKB/TNF/VEGFA/ICAM1/IL1B",5]
["GO:0007616","long-term memory","3/143","32/18670",0.00185463052232191,0.00602048464663919,0.002802337091087,"MTOR/SGK1/PRKCZ",3]
["GO:0071295","cellular response to vitamin","3/143","32/18670",0.00185463052232191,0.00602048464663919,0.002802337091087,"VDR/PPARG/CASR",3]
["GO:1902235","regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway","3/143","32/18670",0.00185463052232191,0.00602048464663919,0.002802337091087,"PTPN1/SIRT1/EIF2AK3",3]
["GO:0045619","regulation of lymphocyte differentiation","6/143","169/18670",0.00193656504546637,0.00628142251926912,0.00292379506695749,"TLR9/IL2/SHH/PRKCZ/GLI2/CYP26B1",6]
["GO:0042698","ovulation cycle","4/143","69/18670",0.00193989841430205,0.00628216702487575,0.00292414160976898,"NOS3/ESR1/CASP3/SIRT1",4]
["GO:0070227","lymphocyte apoptotic process","4/143","69/18670",0.00193989841430205,0.00628216702487575,0.00292414160976898,"AKT1/IL2/HIF1A/TP53",4]
["GO:0050768","negative regulation of neurogenesis","8/143","295/18670",0.00199537885138481,0.00645198405608974,0.00300318583846491,"GSK3B/F2/STAT3/SHH/TNF/IL6/TP53/IL1B",8]
["GO:0006304","DNA modification","5/143","116/18670",0.00199552471300009,0.00645198405608974,0.00300318583846491,"PIK3CA/FOS/PRMT7/PARP2/FTO",5]
["GO:0010464","regulation of mesenchymal cell proliferation","3/143","33/18670",0.00202873208525695,0.00654367129969731,0.00304586322718384,"FGFR1/SHH/VEGFA",3]
["GO:2000352","negative regulation of endothelial cell apoptotic process","3/143","33/18670",0.00202873208525695,0.00654367129969731,0.00304586322718384,"SERPINE1/ICAM1/NFE2L2",3]
["GO:2000758","positive regulation of peptidyl-lysine acetylation","3/143","33/18670",0.00202873208525695,0.00654367129969731,0.00304586322718384,"MAPK3/PRKAA2/IL1B",3]
["GO:0001818","negative regulation of cytokine production","8/143","296/18670",0.00203780470935966,0.00656770180214005,0.00305704863371923,"TLR4/FGFR1/TLR9/F2/TNF/HMOX1/IL6/PTPN22",8]
["GO:0034121","regulation of toll-like receptor signaling pathway","4/143","70/18670",0.00204538409822442,0.00658688530597648,0.00306597792222225,"TLR4/TLR9/ESR1/PTPN22",4]
["GO:0002761","regulation of myeloid leukocyte differentiation","5/143","117/18670",0.00207197509030373,0.00665663108376945,0.00309844228207492,"TLR4/MTOR/PIK3R1/TNF/FOS",5]
["GO:0043666","regulation of phosphoprotein phosphatase activity","5/143","117/18670",0.00207197509030373,0.00665663108376945,0.00309844228207492,"GSK3B/MTOR/IKBKB/TNF/IGFBP3",5]
["GO:1901222","regulation of NIK/NF-kappaB signaling","5/143","117/18670",0.00207197509030373,0.00665663108376945,0.00309844228207492,"TLR4/TLR9/TNF/PTPN22/IL1B",5]
["GO:0042531","positive regulation of tyrosine phosphorylation of STAT protein","4/143","71/18670",0.0021547694174046,0.00691713449774293,0.00321969803176614,"STAT3/IL2/TNF/IL6",4]
["GO:0006909","phagocytosis","9/143","369/18670",0.00218309198865407,0.00700250108563525,0.00325943336365901,"TLR4/MAPK1/PIK3CA/MAPK3/YES1/PIK3R1/PPARG/TNF/IL1B",9]
["GO:0007435","salivary gland morphogenesis","3/143","34/18670",0.00221267379004661,0.00705267992292023,0.00328278995788101,"FGFR1/SHH/TNF",3]
["GO:0032660","regulation of interleukin-17 production","3/143","34/18670",0.00221267379004661,0.00705267992292023,0.00328278995788101,"TLR4/IL2/IL6",3]
["GO:0043276","anoikis","3/143","34/18670",0.00221267379004661,0.00705267992292023,0.00328278995788101,"PIK3CA/MTOR/AKT1",3]
["GO:0048566","embryonic digestive tract development","3/143","34/18670",0.00221267379004661,0.00705267992292023,0.00328278995788101,"SHH/TNF/GLI2",3]
["GO:0070884","regulation of calcineurin-NFAT signaling cascade","3/143","34/18670",0.00221267379004661,0.00705267992292023,0.00328278995788101,"GSK3B/MTOR/TNF",3]
["GO:0071868","cellular response to monoamine stimulus","3/143","34/18670",0.00221267379004661,0.00705267992292023,0.00328278995788101,"MAPK1/MAPK3/KCNQ1",3]
["GO:0071870","cellular response to catecholamine stimulus","3/143","34/18670",0.00221267379004661,0.00705267992292023,0.00328278995788101,"MAPK1/MAPK3/KCNQ1",3]
["GO:0106056","regulation of calcineurin-mediated signaling","3/143","34/18670",0.00221267379004661,0.00705267992292023,0.00328278995788101,"GSK3B/MTOR/TNF",3]
["GO:0001952","regulation of cell-matrix adhesion","5/143","119/18670",0.0022312625320329,0.00710633416968463,0.00330776424062188,"GSK3B/PIK3R1/VEGFA/SERPINE1/PRKCZ",5]
["GO:0002695","negative regulation of leukocyte activation","6/143","175/18670",0.00230738824599286,0.00734300913504645,0.00341792863317379,"CNR1/CASP3/IL2/SHH/HMOX1/PTPN22",6]
["GO:0006721","terpenoid metabolic process","5/143","120/18670",0.0023141684510654,0.00735880117039493,0.00342527930492171,"AKR1B1/TTR/CYP3A4/CYP26B1/RBP4",5]
["GO:0001701","in utero embryonic development","9/143","373/18670",0.00234719145797505,0.00745795213648586,0.00347143081035721,"AR/MAPK1/FGFR1/AKT1/NOS3/VEGFA/HIF1A/GLI2/TP53",9]
["GO:0031100","animal organ regeneration","4/143","73/18670",0.0023855291119797,0.00756788545869424,0.00352260114704147,"PPARG/HMOX1/PGF/NR0B2",4]
["GO:0043627","response to estrogen","4/143","73/18670",0.0023855291119797,0.00756788545869424,0.00352260114704147,"MAPK1/ESR1/PPARG/HMOX1",4]
["GO:0043618","regulation of transcription from RNA polymerase II promoter in response to stress","5/143","121/18670",0.00239929516067929,0.00760506909518653,0.00353990890378196,"VEGFA/HMOX1/HIF1A/TP53/NFE2L2",5]
["GO:0032735","positive regulation of interleukin-12 production","3/143","35/18670",0.00240664365388685,0.00760506909518653,0.00353990890378196,"TLR4/MAPK14/TLR9",3]
["GO:0098801","regulation of renal system process","3/143","35/18670",0.00240664365388685,0.00760506909518653,0.00353990890378196,"AVPR2/AVPR1A/AGTR1",3]
["GO:1901030","positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway","3/143","35/18670",0.00240664365388685,0.00760506909518653,0.00353990890378196,"GSK3B/MAPK8/TP53",3]
["GO:1903539","protein localization to postsynaptic membrane","3/143","35/18670",0.00240664365388685,0.00760506909518653,0.00353990890378196,"MAPK10/HRAS/PRKCZ",3]
["GO:0032434","regulation of proteasomal ubiquitin-dependent protein catabolic process","5/143","122/18670",0.00248667721133232,0.0077869991726011,0.00362459135608383,"GSK3B/AKT1/SHH/OGT/NFE2L2",5]
["GO:0043507","positive regulation of JUN kinase activity","4/143","74/18670",0.00250704763420595,0.0077869991726011,0.00362459135608383,"TLR9/PTPN1/TNF/MAP3K9",4]
["GO:0072078","nephron tubule morphogenesis","4/143","74/18670",0.00250704763420595,0.0077869991726011,0.00362459135608383,"SHH/VEGFA/FGF2/PGF",4]
["GO:0010950","positive regulation of endopeptidase activity","6/143","178/18670",0.00251172786778501,0.0077869991726011,0.00362459135608383,"STAT3/PPARG/ALOX12/TNF/SIRT1/EIF2AK3",6]
["GO:0010918","positive regulation of mitochondrial membrane potential","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"AKT1/AKT2",2]
["GO:0021936","regulation of cerebellar granule cell precursor proliferation","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"SHH/GLI2",2]
["GO:0031284","positive regulation of guanylate cyclase activity","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"NOS2/NOS3",2]
["GO:0032000","positive regulation of fatty acid beta-oxidation","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"PPARA/AKT2",2]
["GO:0032070","regulation of deoxyribonuclease activity","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"AKT1/SIRT1",2]
["GO:0033210","leptin-mediated signaling pathway","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"STAT3/SIRT1",2]
["GO:0035768","endothelial cell chemotaxis to fibroblast growth factor","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"FGFR1/FGF2",2]
["GO:0043084","penile erection","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"CNR1/AVPR1A",2]
["GO:0045348","positive regulation of MHC class II biosynthetic process","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"TLR4/SIRT1",2]
["GO:0045792","negative regulation of cell size","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"MTOR/AKT1",2]
["GO:0045945","positive regulation of transcription by RNA polymerase III","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"AR/MTOR",2]
["GO:0051918","negative regulation of fibrinolysis","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"F2/SERPINE1",2]
["GO:0060068","vagina development","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"ESR1/RBP4",2]
["GO:0060768","regulation of epithelial cell proliferation involved in prostate gland development","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"AR/SHH",2]
["GO:0070391","response to lipoteichoic acid","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"TLR4/MAPK14",2]
["GO:0071223","cellular response to lipoteichoic acid","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"TLR4/MAPK14",2]
["GO:0090336","positive regulation of brown fat cell differentiation","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"MAPK14/PTGS2",2]
["GO:0140052","cellular response to oxidised low-density lipoprotein particle stimulus","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"TLR4/AKT1",2]
["GO:1900222","negative regulation of amyloid-beta clearance","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"HMGCR/TNF",2]
["GO:1903799","negative regulation of production of miRNAs involved in gene silencing by miRNA","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"ESR1/TP53",2]
["GO:1904338","regulation of dopaminergic neuron differentiation","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"GSK3B/SHH",2]
["GO:2000109","regulation of macrophage apoptotic process","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"SIRT1/CCR5",2]
["GO:2000544","regulation of endothelial cell chemotaxis to fibroblast growth factor","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"FGFR1/FGF2",2]
["GO:2001054","negative regulation of mesenchymal cell apoptotic process","2/143","10/18670",0.0025180785367922,0.0077869991726011,0.00362459135608383,"SHH/HIF1A",2]
["GO:0071621","granulocyte chemotaxis","5/143","123/18670",0.00257634919086308,0.00796111566764408,0.00370563684342701,"MAPK14/PIK3CG/MAPK3/HRH1/IL1B",5]
["GO:0071347","cellular response to interleukin-1","6/143","179/18670",0.00258277548468856,0.00797488570710854,0.00371204634276168,"MAPK3/IKBKB/IL6/HIF1A/ICAM1/IL1B",6]
["GO:0009112","nucleobase metabolic process","3/143","36/18670",0.00261082370301299,0.00801867553095342,0.00373242906189063,"MAPK1/MTOR/TTR",3]
["GO:0010453","regulation of cell fate commitment","3/143","36/18670",0.00261082370301299,0.00801867553095342,0.00373242906189063,"AR/FGFR1/FGF2",3]
["GO:0032733","positive regulation of interleukin-10 production","3/143","36/18670",0.00261082370301299,0.00801867553095342,0.00373242906189063,"TLR4/TLR9/PRKCZ",3]
["GO:0045740","positive regulation of DNA replication","3/143","36/18670",0.00261082370301299,0.00801867553095342,0.00373242906189063,"FGFR1/HRAS/GLI2",3]
["GO:0090218","positive regulation of lipid kinase activity","3/143","36/18670",0.00261082370301299,0.00801867553095342,0.00373242906189063,"FLT1/F2/FGF2",3]
["GO:1901099","negative regulation of signal transduction in absence of ligand","3/143","36/18670",0.00261082370301299,0.00801867553095342,0.00373242906189063,"AKT1/TNF/IL1B",3]
["GO:2001240","negative regulation of extrinsic apoptotic signaling pathway in absence of ligand","3/143","36/18670",0.00261082370301299,0.00801867553095342,0.00373242906189063,"AKT1/TNF/IL1B",3]
["GO:0006695","cholesterol biosynthetic process","4/143","75/18670",{"v":0.00263275404463347,"d":"2.63E-03"},{"v":0.00806766720111754,"d":"8.07E-03"},{"v":0.00375523306896203,"d":"3.76E-03"},"HMGCR/CFTR/PRKAA2/ACACB",4]
["GO:0010611","regulation of cardiac muscle hypertrophy","4/143","75/18670",{"v":0.00263275404463347,"d":"2.63E-03"},{"v":0.00806766720111754,"d":"8.07E-03"},{"v":0.00375523306896203,"d":"3.76E-03"},"MTOR/PPARA/FOXO1/PARP2",4]
["GO:0046173","polyol biosynthetic process","4/143","75/18670",{"v":0.00263275404463347,"d":"2.63E-03"},{"v":0.00806766720111754,"d":"8.07E-03"},{"v":0.00375523306896203,"d":"3.76E-03"},"HRH1/AKR1B1/FGF2/CYP3A4",4]
["GO:0071346","cellular response to interferon-gamma","6/143","180/18670",{"v":0.00265532318106894,"d":"2.66E-03"},{"v":0.00812452625621095,"d":"8.12E-03"},{"v":0.00378169908430872,"d":"3.78E-03"},"TLR4/NOS2/PPARG/GAPDH/TP53/ICAM1",6]
["GO:0071466","cellular response to xenobiotic stimulus","6/143","180/18670",{"v":0.00265532318106894,"d":"2.66E-03"},{"v":0.00812452625621095,"d":"8.12E-03"},{"v":0.00378169908430872,"d":"3.78E-03"},"HNF4A/CYP3A4/AOC3/FOXO1/CYP26B1/ICAM1",6]
["GO:0019751","polyol metabolic process","5/143","124/18670",{"v":0.00266834571794886,"d":"2.67E-03"},{"v":0.00815820503493731,"d":"8.16E-03"},{"v":0.00379737544532395,"d":"3.80E-03"},"HRH1/AKR1B1/FGF2/CYP3A4/SORD",5]
["GO:0030900","forebrain development","9/143","381/18670",{"v":0.00270483190885673,"d":"2.70E-03"},{"v":0.00826351665437889,"d":"8.26E-03"},{"v":0.00384639453176051,"d":"3.85E-03"},"GSK3B/FGFR1/CASP3/SLC2A1/AVPR2/AVPR1A/SHH/HIF1A/GLI2",9]
["GO:0042113","B cell activation","8/143","310/18670",{"v":0.00270994685782954,"d":"2.71E-03"},{"v":0.00827289960821566,"d":"8.27E-03"},{"v":0.00385076198738975,"d":"3.85E-03"},"TLR4/TLR9/PRKCB/PIK3R1/CASP3/IL2/IL6/TP53",8]
["GO:0045454","cell redox homeostasis","4/143","76/18670",{"v":0.00276271939771058,"d":"2.76E-03"},{"v":0.00841496472681147,"d":"8.41E-03"},{"v":0.00391688861581873,"d":"3.92E-03"},"NOS2/NOS3/GSR/NFE2L2",4]
["GO:0072088","nephron epithelium morphogenesis","4/143","76/18670",{"v":0.00276271939771058,"d":"2.76E-03"},{"v":0.00841496472681147,"d":"8.41E-03"},{"v":0.00391688861581873,"d":"3.92E-03"},"SHH/VEGFA/FGF2/PGF",4]
["GO:1902653","secondary alcohol biosynthetic process","4/143","76/18670",{"v":0.00276271939771058,"d":"2.76E-03"},{"v":0.00841496472681147,"d":"8.41E-03"},{"v":0.00391688861581873,"d":"3.92E-03"},"HMGCR/CFTR/PRKAA2/ACACB",4]
["GO:0003156","regulation of animal organ formation","3/143","37/18670",{"v":0.00282539007098585,"d":"2.83E-03"},{"v":0.00856076273005295,"d":"8.56E-03"},{"v":0.00398475277896681,"d":"3.98E-03"},"AR/FGFR1/SHH",3]
["GO:0007431","salivary gland development","3/143","37/18670",{"v":0.00282539007098585,"d":"2.83E-03"},{"v":0.00856076273005295,"d":"8.56E-03"},{"v":0.00398475277896681,"d":"3.98E-03"},"FGFR1/SHH/TNF",3]
["GO:0014912","negative regulation of smooth muscle cell migration","3/143","37/18670",{"v":0.00282539007098585,"d":"2.83E-03"},{"v":0.00856076273005295,"d":"8.56E-03"},{"v":0.00398475277896681,"d":"3.98E-03"},"SERPINE1/IGFBP3/NFE2L2",3]
["GO:0030212","hyaluronan metabolic process","3/143","37/18670",{"v":0.00282539007098585,"d":"2.83E-03"},{"v":0.00856076273005295,"d":"8.56E-03"},{"v":0.00398475277896681,"d":"3.98E-03"},"AKT1/FGF2/IL1B",3]
["GO:0033280","response to vitamin D","3/143","37/18670",{"v":0.00282539007098585,"d":"2.83E-03"},{"v":0.00856076273005295,"d":"8.56E-03"},{"v":0.00398475277896681,"d":"3.98E-03"},"PTGS2/VDR/CASR",3]
["GO:0043029","T cell homeostasis","3/143","37/18670",{"v":0.00282539007098585,"d":"2.83E-03"},0.00856076273005295,{"v":0.00398475277896681,"d":"3.98E-03"},"AKT1/CASP3/IL2",3]
["GO:0043114","regulation of vascular permeability","3/143","37/18670",{"v":0.00282539007098585,"d":"2.83E-03"},0.00856076273005295,{"v":0.00398475277896681,"d":"3.98E-03"},"HRH1/YES1/VEGFA",3]
["GO:0038061","NIK/NF-kappaB signaling","6/143","183/18670",{"v":0.00288216521959666,"d":"2.88E-03"},0.0087262564015911,{"v":0.00406178462628668,"d":"4.06E-03"},"TLR4/TLR9/AKT1/TNF/PTPN22/IL1B",6]
["GO:0061418","regulation of transcription from RNA polymerase II promoter in response to hypoxia","4/143","77/18670",{"v":0.00289701430571515,"d":"2.90E-03"},0.00875811344998873,{"v":0.00407661303190135,"d":"4.08E-03"},"VEGFA/HIF1A/TP53/NFE2L2",4]
["GO:1901224","positive regulation of NIK/NF-kappaB signaling","4/143","77/18670",{"v":0.00289701430571515,"d":"2.90E-03"},0.00875811344998873,{"v":0.00407661303190135,"d":"4.08E-03"},"TLR4/TLR9/TNF/IL1B",4]
["GO:0043620","regulation of DNA-templated transcription in response to stress","5/143","127/18670",{"v":0.0029586290976233,"d":"2.96E-03"},0.00893104443488376,{"v":0.00415710670336018,"d":"4.16E-03"},"VEGFA/HMOX1/HIF1A/TP53/NFE2L2",5]
["GO:0045727","positive regulation of translation","5/143","127/18670",{"v":0.0029586290976233,"d":"2.96E-03"},0.00893104443488376,{"v":0.00415710670336018,"d":"4.16E-03"},"MAPK1/MTOR/MAPK3/TNF/IL6",5]
["GO:0014743","regulation of muscle hypertrophy","4/143","78/18670",{"v":0.00303570892043382,"d":"3.04E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"MTOR/PPARA/FOXO1/PARP2",4]
["GO:0043407","negative regulation of MAP kinase activity","4/143","78/18670",{"v":0.00303570892043382,"d":"3.04E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"HMGCR/PTPN1/PTPN22/IL1B",4]
["GO:0061333","renal tubule morphogenesis","4/143","78/18670",{"v":0.00303570892043382,"d":"3.04E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"SHH/VEGFA/FGF2/PGF",4]
["GO:0072028","nephron morphogenesis","4/143","78/18670",{"v":0.00303570892043382,"d":"3.04E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"SHH/VEGFA/FGF2/PGF",4]
["GO:0043543","protein acylation","7/143","248/18670",{"v":0.00303735680416551,"d":"3.04E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"GSK3B/MAPK3/SIRT1/FOXO1/OGT/PRKAA2/IL1B",7]
["GO:0050851","antigen receptor-mediated signaling pathway","8/143","316/18670",{"v":0.0030462744412554,"d":"3.05E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"MAPK1/PIK3CA/PRKCB/BLK/PIK3R1/IKBKB/HRAS/PTPN22",8]
["GO:0003298","physiological muscle hypertrophy","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"MTOR/PPARA/PARP2",3]
["GO:0003301","physiological cardiac muscle hypertrophy","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"MTOR/PPARA/PARP2",3]
["GO:0007190","activation of adenylate cyclase activity","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"ADRB3/AVPR2/ADRB2",3]
["GO:0010831","positive regulation of myotube differentiation","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"MAPK14/MTOR/CYP26B1",3]
["GO:0032094","response to food","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"MTOR/AKT1/PPARA",3]
["GO:0032620","interleukin-17 production","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"TLR4/IL2/IL6",3]
["GO:0046676","negative regulation of insulin secretion","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"HMGCR/MTNR1B/KCNJ11",3]
["GO:0046825","regulation of protein export from nucleus","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"GSK3B/TP53/IL1B",3]
["GO:0048246","macrophage chemotaxis","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,{"v":0.00420239091750013,"d":"4.20E-03"},"MAPK14/MAPK3/CYP19A1",3]
["GO:0061049","cell growth involved in cardiac muscle cell development","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,0.00420239091750013,"MTOR/PPARA/PARP2",3]
["GO:0071867","response to monoamine","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,0.00420239091750013,"MAPK1/MAPK3/KCNQ1",3]
["GO:0071869","response to catecholamine","3/143","38/18670",{"v":0.00305051309570868,"d":"3.05E-03"},0.00902833212979805,0.00420239091750013,"MAPK1/MAPK3/KCNQ1",3]
["GO:0006853","carnitine shuttle","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"PRKAA2/ACACB",2]
["GO:0033089","positive regulation of T cell differentiation in thymus","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"SHH/GLI2",2]
["GO:0035766","cell chemotaxis to fibroblast growth factor","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"FGFR1/FGF2",2]
["GO:0045351","type I interferon biosynthetic process","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"TLR4/TLR9",2]
["GO:0045899","positive regulation of RNA polymerase II transcriptional preinitiation complex assembly","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"ESR1/TP53",2]
["GO:0051974","negative regulation of telomerase activity","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"PPARG/TP53",2]
["GO:0055091","phospholipid homeostasis","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"HNF4A/CETP",2]
["GO:0060767","epithelial cell proliferation involved in prostate gland development","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"AR/SHH",2]
["GO:0061307","cardiac neural crest cell differentiation involved in heart development","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"MAPK1/MAPK3",2]
["GO:0061308","cardiac neural crest cell development involved in heart development","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"MAPK1/MAPK3",2]
["GO:0072584","caveolin-mediated endocytosis","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"MAPK1/MAPK3",2]
["GO:1901894","regulation of calcium-transporting ATPase activity","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"TLR9/ATP2A1",2]
["GO:1904847","regulation of cell chemotaxis to fibroblast growth factor","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"FGFR1/FGF2",2]
["GO:2000551","regulation of T-helper 2 cell cytokine production","2/143","11/18670",{"v":0.00306222826438061,"d":"3.06E-03"},0.00902833212979805,0.00420239091750013,"IL6/PRKCZ",2]
["GO:0071482","cellular response to light stimulus","5/143","129/18670",{"v":0.00316440956327831,"d":"3.16E-03"},0.00932280197390874,0.00433945692045367,"PTGS2/PIK3R1/AKT2/SIRT1/TP53",5]
["GO:0048167","regulation of synaptic plasticity","6/143","187/18670",{"v":0.00320683112668172,"d":"3.21E-03"},0.00944091083695098,0.00439443270182605,"GSK3B/PTGS2/MAPK1/HRH1/HRAS/PRKCZ",6]
["GO:0008016","regulation of heart contraction","7/143","251/18670",0.00324570913310816,0.00954148915818578,0.0044412485940172,"PIK3CG/KCNQ1/NOS3/AVPR1A/IL2/KCNJ11/ATP2A1",7]
["GO:0021537","telencephalon development","7/143","251/18670",0.00324570913310816,0.00954148915818578,0.0044412485940172,"GSK3B/CASP3/SLC2A1/AVPR2/AVPR1A/SHH/HIF1A",7]
["GO:0010661","positive regulation of muscle cell apoptotic process","3/143","39/18670",0.00328635741518984,0.00959825022849096,0.00446766900067579,"HMGCR/PPARG/TP53",3]
["GO:0033574","response to testosterone","3/143","39/18670",0.00328635741518984,0.00959825022849096,0.00446766900067579,"AR/SIRT1/KCNJ11",3]
["GO:0048713","regulation of oligodendrocyte differentiation","3/143","39/18670",0.00328635741518984,0.00959825022849096,0.00446766900067579,"MTOR/PPARG/SHH",3]
["GO:0055090","acylglycerol homeostasis","3/143","39/18670",0.00328635741518984,0.00959825022849096,0.00446766900067579,"HNF4A/SIRT1/CETP",3]
["GO:0060969","negative regulation of gene silencing","3/143","39/18670",0.00328635741518984,0.00959825022849096,0.00446766900067579,"ESR1/PPARG/TP53",3]
["GO:0070328","triglyceride homeostasis","3/143","39/18670",0.00328635741518984,0.00959825022849096,0.00446766900067579,"HNF4A/SIRT1/CETP",3]
["GO:0072595","maintenance of protein localization in organelle","3/143","39/18670",0.00328635741518984,0.00959825022849096,0.00446766900067579,"AKT1/HK2/HK1",3]
["GO:1905521","regulation of macrophage migration","3/143","39/18670",0.00328635741518984,0.00959825022849096,0.00446766900067579,"MAPK14/MAPK3/CYP19A1",3]
["GO:2000648","positive regulation of stem cell proliferation","3/143","39/18670",0.00328635741518984,0.00959825022849096,0.00446766900067579,"SHH/VEGFA/HIF1A",3]
["GO:0006470","protein dephosphorylation","8/143","321/18670",0.00335068748965479,0.00977907927766588,0.00455183896063603,"GSK3B/MTOR/IKBKB/PTPN1/TNF/ACP1/IGFBP3/PTPN22",8]
["GO:0098754","detoxification","5/143","131/18670",0.00338032019926663,0.00985845545146347,0.00458878595228823,"PTGS2/NOS3/TNF/GSR/NFE2L2",5]
["GO:2000027","regulation of animal organ morphogenesis","7/143","253/18670",0.00339056604525897,0.00988121767545595,0.00459938101702365,"AR/FGFR1/ESR1/VDR/SHH/TNF/VEGFA",7]
["GO:0014032","neural crest cell development","4/143","81/18670",0.00347888524621423,0.0101167582447379,0.00470901738560456,"MAPK1/MAPK3/SHH/HIF1A",4]
["GO:0016126","sterol biosynthetic process","4/143","81/18670",0.00347888524621423,0.0101167582447379,0.00470901738560456,"HMGCR/CFTR/PRKAA2/ACACB",4]
["GO:0110110","positive regulation of animal organ morphogenesis","4/143","81/18670",0.00347888524621423,0.0101167582447379,0.00470901738560456,"AR/FGFR1/VDR/VEGFA",4]
["GO:0042476","odontogenesis","5/143","132/18670",0.00349216095348884,0.0101407945048227,0.00472020547213246,"PPARA/SHH/SERPINE1/FOXO1/GLI2",5]
["GO:0043280","positive regulation of cysteine-type endopeptidase activity involved in apoptotic process","5/143","132/18670",0.00349216095348884,0.0101407945048227,0.00472020547213246,"PPARG/ALOX12/TNF/SIRT1/EIF2AK3",5]
["GO:0002429","immune response-activating cell surface receptor signaling pathway","10/143","473/18670",0.00353268910011206,0.0102375921168501,0.00476526156884793,"MAPK1/PIK3CA/PRKCB/MAPK3/BLK/YES1/PIK3R1/IKBKB/HRAS/PTPN22",10]
["GO:0002369","T cell cytokine production","3/143","40/18670",0.0035330820620651,0.0102375921168501,0.00476526156884793,"IL6/PRKCZ/IL1B",3]
["GO:0045823","positive regulation of heart contraction","3/143","40/18670",0.0035330820620651,0.0102375921168501,0.00476526156884793,"KCNQ1/AVPR1A/ATP2A1",3]
["GO:0002705","positive regulation of leukocyte mediated immunity","5/143","133/18670",0.00360663815228949,0.0103936658523948,0.00483790874656407,"IL2/TNF/IL6/PRKCZ/IL1B",5]
["GO:0006839","mitochondrial transport","7/143","256/18670",0.00361704696010608,0.0103936658523948,0.00483790874656407,"GSK3B/MAPK8/STAT3/HK2/TP53/PRKAA2/ACACB",7]
["GO:0034644","cellular response to UV","4/143","82/18670",0.00363587038564077,0.0103936658523948,0.00483790874656407,"PTGS2/PIK3R1/SIRT1/TP53",4]
["GO:0090049","regulation of cell migration involved in sprouting angiogenesis","4/143","82/18670",0.00363587038564077,0.0103936658523948,0.00483790874656407,"PTGS2/VEGFA/FGF2/HMOX1",4]
["GO:0043112","receptor metabolic process","6/143","192/18670",0.00365016982256922,0.0103936658523948,0.00483790874656407,"PTPN1/PPARG/PPARA/TNF/VEGFA/HIF1A",6]
["GO:0002002","regulation of angiotensin levels in blood","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"REN/ACE",2]
["GO:0002003","angiotensin maturation","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"REN/ACE",2]
["GO:0002024","diet induced thermogenesis","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"ADRB2/MC4R",2]
["GO:0002551","mast cell chemotaxis","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"VEGFA/PGF",2]
["GO:0002863","positive regulation of inflammatory response to antigenic stimulus","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"CNR1/TNF",2]
["GO:0006527","arginine catabolic process","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"NOS2/NOS3",2]
["GO:0010889","regulation of sequestering of triglyceride","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"PPARG/PPARA",2]
["GO:0031282","regulation of guanylate cyclase activity","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"NOS2/NOS3",2]
["GO:0051095","regulation of helicase activity","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"SIRT1/TP53",2]
["GO:0051549","positive regulation of keratinocyte migration","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"MMP9/MTOR",2]
["GO:0051873","killing by host of symbiont cells","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"F2/GAPDH",2]
["GO:0060081","membrane hyperpolarization","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"CFTR/PRKCZ",2]
["GO:0060442","branching involved in prostate gland morphogenesis","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"ESR1/SHH",2]
["GO:0060453","regulation of gastric acid secretion","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"KCNQ1/SGK1",2]
["GO:0070243","regulation of thymocyte apoptotic process","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"HIF1A/TP53",2]
["GO:0071888","macrophage apoptotic process","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"SIRT1/CCR5",2]
["GO:0072540","T-helper 17 cell lineage commitment","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"STAT3/IL6",2]
["GO:0097531","mast cell migration","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"VEGFA/PGF",2]
["GO:0099550","trans-synaptic signaling, modulating synaptic transmission","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"CNR1/PLAT",2]
["GO:0150065","regulation of deacetylase activity","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"MAPK8/VEGFA",2]
["GO:2000121","regulation of removal of superoxide radicals","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"TNF/NFE2L2",2]
["GO:2001053","regulation of mesenchymal cell apoptotic process","2/143","12/18670",0.00365626980578317,0.0103936658523948,0.00483790874656407,"SHH/HIF1A",2]
["GO:0007006","mitochondrial membrane organization","5/143","134/18670",0.00372378637227004,0.0105707484116053,0.00492033483897791,"GSK3B/MAPK8/STAT3/HK2/TP53",5]
["GO:0032355","response to estradiol","5/143","134/18670",0.00372378637227004,0.0105707484116053,0.00492033483897791,"PTGS2/STAT3/ESR1/CASP3/KCNJ11",5]
["GO:0051224","negative regulation of protein transport","6/143","193/18670",0.00374404110989494,0.0106207977665415,0.00494363116343595,"HMGCR/MTNR1B/TNF/KCNJ11/PTPN22/IL1B",6]
["GO:0030890","positive regulation of B cell proliferation","3/143","41/18670",0.00379084055689368,0.0107460242116986,0.00500191994459655,"TLR4/TLR9/IL2",3]
["GO:0042509","regulation of tyrosine phosphorylation of STAT protein","4/143","83/18670",0.00379759848070752,0.0107501249300028,0.00500382869375522,"STAT3/IL2/TNF/IL6",4]
["GO:0045582","positive regulation of T cell differentiation","4/143","83/18670",0.00379759848070752,0.0107501249300028,0.00500382869375522,"IL2/SHH/PRKCZ/GLI2",4]
["GO:0032412","regulation of ion transmembrane transporter activity","7/143","260/18670",0.00393674268610352,0.0111362224970979,0.00518354438054014,"MMP9/TLR9/MTNR1B/CFTR/KCNJ11/ADRB2/ATP2A1",7]
["GO:0042742","defense response to bacterium","8/143","330/18670",0.00395775916968343,0.0111878555299431,0.00520757785484663,"TLR4/NOS2/TLR9/SELP/F2/TNF/SERPINE1/IL6",8]
["GO:0014910","regulation of smooth muscle cell migration","4/143","84/18670",0.00396413656614136,0.0111902544070713,0.00520869445305222,"SERPINE1/ACE/IGFBP3/NFE2L2",4]
["GO:0043154","negative regulation of cysteine-type endopeptidase activity involved in apoptotic process","4/143","84/18670",0.00396413656614136,0.0111902544070713,0.00520869445305222,"PTGS2/MMP9/AKT1/VEGFA",4]
["GO:0071897","DNA biosynthetic process","6/143","196/18670",0.00403642899190419,0.0113863864524238,0.0052999874531513,"MAPK1/MAPK3/PPARG/FGF2/SIRT1/TP53",6]
["GO:0006509","membrane protein ectodomain proteolysis","3/143","42/18670",0.00405978100024202,0.011428368212086,0.00531952857802007,"BACE2/TNF/IL1B",3]
["GO:0031641","regulation of myelination","3/143","42/18670",0.00405978100024202,0.011428368212086,0.00531952857802007,"MTOR/AKT1/EIF2AK3",3]
["GO:1903146","regulation of autophagy of mitochondrion","3/143","42/18670",0.00405978100024202,0.011428368212086,0.00531952857802007,"HK2/HIF1A/TP53",3]
["GO:0060048","cardiac muscle contraction","5/143","137/18670",0.00409160231598735,0.0114939668113232,0.00535006256299891,"PIK3CA/PIK3CG/MTOR/KCNQ1/ATP2A1",5]
["GO:0072655","establishment of protein localization to mitochondrion","5/143","137/18670",0.00409160231598735,0.0114939668113232,0.00535006256299891,"MAPK8/AKT1/HK2/HK1/TP53",5]
["GO:1903670","regulation of sprouting angiogenesis","5/143","137/18670",0.00409160231598735,0.0114939668113232,0.00535006256299891,"PTGS2/VEGFA/FGF2/HMOX1/AGTR1",5]
["GO:0014031","mesenchymal cell development","4/143","85/18670",0.00413555110304079,0.0115988968400264,0.00539890403152881,"MAPK1/MAPK3/SHH/HIF1A",4]
["GO:0048864","stem cell development","4/143","85/18670",0.00413555110304079,0.0115988968400264,0.00539890403152881,"MAPK1/MAPK3/SHH/HIF1A",4]
["GO:1904950","negative regulation of establishment of protein localization","6/143","197/18670",0.00413755114550347,0.0115988968400264,0.00539890403152881,"HMGCR/MTNR1B/TNF/KCNJ11/PTPN22/IL1B",6]
["GO:0008584","male gonad development","5/143","138/18670",0.0042197795326286,0.0118212232166648,0.00550238962914238,"AR/REN/INSR/ESR1/ICAM1",5]
["GO:0014842","regulation of skeletal muscle satellite cell proliferation","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"STAT3/FGF2",2]
["GO:0032725","positive regulation of granulocyte macrophage colony-stimulating factor production","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"TLR9/IL1B",2]
["GO:0033004","negative regulation of mast cell activation","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"CNR1/HMOX1",2]
["GO:0033127","regulation of histone phosphorylation","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"MAPK3/IL1B",2]
["GO:0034374","low-density lipoprotein particle remodeling","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"AGTR1/CETP",2]
["GO:0035745","T-helper 2 cell cytokine production","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"IL6/PRKCZ",2]
["GO:0043568","positive regulation of insulin-like growth factor receptor signaling pathway","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"AR/IGFBP3",2]
["GO:0045820","negative regulation of glycolytic process","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"STAT3/PPARA",2]
["GO:0070431","nucleotide-binding oligomerization domain containing 2 signaling pathway","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"TLR4/PTPN22",2]
["GO:0071285","cellular response to lithium ion","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"SHH/FABP4",2]
["GO:0090399","replicative senescence","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"SERPINE1/TP53",2]
["GO:0090594","inflammatory response to wounding","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"HMOX1/HIF1A",2]
["GO:0097152","mesenchymal cell apoptotic process","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"SHH/HIF1A",2]
["GO:0099633","protein localization to postsynaptic specialization membrane","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"HRAS/PRKCZ",2]
["GO:0099645","neurotransmitter receptor localization to postsynaptic specialization membrane","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"HRAS/PRKCZ",2]
["GO:1900103","positive regulation of endoplasmic reticulum unfolded protein response","2/143","13/18670",0.00429941779331868,0.0119124183623231,0.00554483796249176,"PIK3R1/PTPN1",2]
["GO:0007260","tyrosine phosphorylation of STAT protein","4/143","86/18670",0.00431190796475722,0.0119306927145162,0.00555334407088206,"STAT3/IL2/TNF/IL6",4]
["GO:0048013","ephrin receptor signaling pathway","4/143","86/18670",0.00431190796475722,0.0119306927145162,0.00555334407088206,"MMP9/YES1/MMP2/HRAS",4]
["GO:0033173","calcineurin-NFAT signaling cascade","3/143","43/18670",0.004340046163569,0.0119646998930053,0.0055691732911586,"GSK3B/MTOR/TNF",3]
["GO:0045687","positive regulation of glial cell differentiation","3/143","43/18670",0.004340046163569,0.0119646998930053,0.0055691732911586,"MTOR/PPARG/SHH",3]
["GO:1901985","positive regulation of protein acetylation","3/143","43/18670",0.004340046163569,0.0119646998930053,0.0055691732911586,"MAPK3/PRKAA2/IL1B",3]
["GO:0034341","response to interferon-gamma","6/143","199/18670",0.00434540771719981,0.0119646998930053,0.0055691732911586,"TLR4/NOS2/PPARG/GAPDH/TP53/ICAM1",6]
["GO:0002433","immune response-regulating cell surface receptor signaling pathway involved in phagocytosis","5/143","139/18670",0.00435079996109284,0.0119646998930053,0.0055691732911586,"MAPK1/PIK3CA/MAPK3/YES1/PIK3R1",5]
["GO:0035304","regulation of protein dephosphorylation","5/143","139/18670",0.00435079996109284,0.0119646998930053,0.0055691732911586,"GSK3B/MTOR/IKBKB/TNF/IGFBP3",5]
["GO:0038096","Fc-gamma receptor signaling pathway involved in phagocytosis","5/143","139/18670",0.00435079996109284,0.0119646998930053,0.0055691732911586,"MAPK1/PIK3CA/MAPK3/YES1/PIK3R1",5]
["GO:0045580","regulation of T cell differentiation","5/143","139/18670",0.00435079996109284,0.0119646998930053,0.0055691732911586,"IL2/SHH/PRKCZ/GLI2/CYP26B1",5]
["GO:0046546","development of primary male sexual characteristics","5/143","139/18670",0.00435079996109284,0.0119646998930053,0.0055691732911586,"AR/REN/INSR/ESR1/ICAM1",5]
["GO:0001837","epithelial to mesenchymal transition","5/143","140/18670",0.00448469785989433,0.012316185167471,0.00573277809698697,"GSK3B/MTOR/IL6/HIF1A/IL1B",5]
["GO:0072073","kidney epithelium development","5/143","140/18670",0.00448469785989433,0.012316185167471,0.00573277809698697,"FGFR1/SHH/VEGFA/FGF2/PGF",5]
["GO:0070585","protein localization to mitochondrion","5/143","141/18670",0.00462150741422038,0.0126343796815997,0.00588088715156632,"MAPK8/AKT1/HK2/HK1/TP53",5]
["GO:0097530","granulocyte migration","5/143","141/18670",0.00462150741422038,0.0126343796815997,0.00588088715156632,"MAPK14/PIK3CG/MAPK3/HRH1/IL1B",5]
["GO:0010463","mesenchymal cell proliferation","3/143","44/18670",0.00463177357892637,0.0126343796815997,0.00588088715156632,"FGFR1/SHH/VEGFA",3]
["GO:0030225","macrophage differentiation","3/143","44/18670",0.00463177357892637,0.0126343796815997,0.00588088715156632,"MMP9/VEGFA/SIRT1",3]
["GO:0032965","regulation of collagen biosynthetic process","3/143","44/18670",0.00463177357892637,0.0126343796815997,0.00588088715156632,"F2/PPARG/IL6",3]
["GO:0034105","positive regulation of tissue remodeling","3/143","44/18670",0.00463177357892637,0.0126343796815997,0.00588088715156632,"VDR/IL2/MC4R",3]
["GO:0038084","vascular endothelial growth factor signaling pathway","3/143","44/18670",0.00463177357892637,0.0126343796815997,0.00588088715156632,"FLT1/VEGFA/PGF",3]
["GO:0046688","response to copper ion","3/143","44/18670",0.00463177357892637,0.0126343796815997,0.00588088715156632,"SORD/ICAM1/NFE2L2",3]
["GO:0070266","necroptotic process","3/143","44/18670",0.00463177357892637,0.0126343796815997,0.00588088715156632,"TLR4/TNF/TP53",3]
["GO:1901028","regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway","3/143","44/18670",0.00463177357892637,0.0126343796815997,0.00588088715156632,"GSK3B/MAPK8/TP53",3]
["GO:0022898","regulation of transmembrane transporter activity","7/143","268/18670",0.00464010580383642,0.0126485847097171,0.00588749912377614,"MMP9/TLR9/MTNR1B/CFTR/KCNJ11/ADRB2/ATP2A1",7]
["GO:0050852","T cell receptor signaling pathway","6/143","202/18670",0.0046715312860668,0.0127256787658132,0.005923383864886,"MAPK1/PIK3CA/PIK3R1/IKBKB/HRAS/PTPN22",6]
["GO:0097194","execution phase of apoptosis","4/143","88/18670",0.00467970913597284,0.0127308216279691,0.0059257776976453,"AKT1/CASP3/IL6/TP53",4]
["GO:1901888","regulation of cell junction assembly","4/143","88/18670",0.00467970913597284,0.0127308216279691,0.0059257776976453,"IKBKB/TNF/VEGFA/ACE",4]
["GO:0038094","Fc-gamma receptor signaling pathway","5/143","142/18670",0.00476126273027814,0.0129352963303127,0.00602095392949337,"MAPK1/PIK3CA/MAPK3/YES1/PIK3R1",5]
["GO:0038127","ERBB signaling pathway","5/143","142/18670",0.00476126273027814,0.0129352963303127,0.00602095392949337,"MAPK1/MMP9/PIK3CA/AKT1/PIK3R1",5]
["GO:0055013","cardiac muscle cell development","4/143","89/18670",0.00487128213308349,0.0132164544736742,0.00615182377467155,"MTOR/PPARA/VEGFA/PARP2",4]
["GO:0097306","cellular response to alcohol","4/143","89/18670",0.00487128213308349,0.0132164544736742,0.00615182377467155,"AKT1/PPARG/CFTR/PRKAA2",4]
["GO:0031396","regulation of protein ubiquitination","6/143","204/18670",0.00489874603695326,0.0132820656112437,0.0061823635958306,"MTOR/AKT1/AVPR2/PTPN22/OGT/ADRB2",6]
["GO:0032309","icosanoid secretion","3/143","45/18670",0.00493509562748756,0.0133090555111642,0.00619492650431243,"NOS2/ACE/IL1B",3]
["GO:0044275","cellular carbohydrate catabolic process","3/143","45/18670",0.00493509562748756,0.0133090555111642,0.00619492650431243,"MGAM/SORD/TREH",3]
["GO:0048538","thymus development","3/143","45/18670",0.00493509562748756,0.0133090555111642,0.00619492650431243,"MAPK1/MAPK3/SHH",3]
["GO:0090278","negative regulation of peptide hormone secretion","3/143","45/18670",0.00493509562748756,0.0133090555111642,0.00619492650431243,"HMGCR/MTNR1B/KCNJ11",3]
["GO:0014841","skeletal muscle satellite cell proliferation","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"STAT3/FGF2",2]
["GO:0032310","prostaglandin secretion","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"NOS2/IL1B",2]
["GO:0034356","NAD biosynthesis via nicotinamide riboside salvage pathway","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"PTGS2/NAMPT",2]
["GO:0035112","genitalia morphogenesis","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"AR/RBP4",2]
["GO:0036092","phosphatidylinositol-3-phosphate biosynthetic process","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"PIK3CA/PIK3CG",2]
["GO:0036295","cellular response to increased oxygen levels","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"PPARG/FOXO1",2]
["GO:0045346","regulation of MHC class II biosynthetic process","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"TLR4/SIRT1",2]
["GO:0048308","organelle inheritance","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"MAPK1/MAPK3",2]
["GO:0048313","Golgi inheritance","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"MAPK1/MAPK3",2]
["GO:0050930","induction of positive chemotaxis","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"VEGFA/PGF",2]
["GO:0051547","regulation of keratinocyte migration","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"MMP9/MTOR",2]
["GO:0051712","positive regulation of killing of cells of other organism","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"NOS2/GAPDH",2]
["GO:0051852","disruption by host of symbiont cells","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"F2/GAPDH",2]
["GO:0051917","regulation of fibrinolysis","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"F2/SERPINE1",2]
["GO:0060397","JAK-STAT cascade involved in growth hormone signaling pathway","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"STAT3/PTPN1",2]
["GO:0060452","positive regulation of cardiac muscle contraction","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"KCNQ1/ATP2A1",2]
["GO:0061051","positive regulation of cell growth involved in cardiac muscle cell development","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"MTOR/PARP2",2]
["GO:0070885","negative regulation of calcineurin-NFAT signaling cascade","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"GSK3B/MTOR",2]
["GO:0099171","presynaptic modulation of chemical synaptic transmission","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"PRKCB/CNR1",2]
["GO:0106057","negative regulation of calcineurin-mediated signaling","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"GSK3B/MTOR",2]
["GO:1903351","cellular response to dopamine","2/143","14/18670",0.00499089581668657,0.0133090555111642,0.00619492650431243,"MAPK1/MAPK3",2]
["GO:1904064","positive regulation of cation transmembrane transport","5/143","144/18670",0.00504974664400476,0.0134571260137796,0.00626384844098854,"F2/KCNQ1/KCNJ11/ADRB2/ATP2A1",5]
["GO:0014033","neural crest cell differentiation","4/143","90/18670",0.0050680548053003,0.0134881563786033,0.00627829205265756,"MAPK1/MAPK3/SHH/HIF1A",4]
["GO:0030641","regulation of cellular pH","4/143","90/18670",0.0050680548053003,0.0134881563786033,0.00627829205265756,"MAPK1/MAPK3/AVPR1A/CFTR",4]
["GO:0002431","Fc receptor mediated stimulatory signaling pathway","5/143","145/18670",0.00519854300912565,0.0138172699283917,0.00643148355830591,"MAPK1/PIK3CA/MAPK3/YES1/PIK3R1",5]
["GO:0002822","regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains","5/143","145/18670",0.00519854300912565,0.0138172699283917,0.00643148355830591,"IL2/TNF/IL6/PRKCZ/IL1B",5]
["GO:0002437","inflammatory response to antigenic stimulus","3/143","46/18670",0.0052501396269187,0.0138905654965797,0.00646560022854109,"CNR1/TNF/ICAM1",3]
["GO:0032369","negative regulation of lipid transport","3/143","46/18670",0.0052501396269187,0.0138905654965797,0.00646560022854109,"AKT1/SHH/AKT2",3]
["GO:0033628","regulation of cell adhesion mediated by integrin","3/143","46/18670",0.0052501396269187,0.0138905654965797,0.00646560022854109,"PIK3CG/SERPINE1/DPP4",3]
["GO:0048512","circadian behavior","3/143","46/18670",0.0052501396269187,0.0138905654965797,0.00646560022854109,"MTOR/MTNR1B/TP53",3]
["GO:0071354","cellular response to interleukin-6","3/143","46/18670",0.0052501396269187,0.0138905654965797,0.00646560022854109,"STAT3/IL6/ICAM1",3]
["GO:0097720","calcineurin-mediated signaling","3/143","46/18670",0.0052501396269187,0.0138905654965797,0.00646560022854109,"GSK3B/MTOR/TNF",3]
["GO:1903587","regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis","3/143","46/18670",0.0052501396269187,0.0138905654965797,0.00646560022854109,"VEGFA/HMOX1/AGTR1",3]
["GO:0070555","response to interleukin-1","6/143","207/18670",0.00525467836536874,0.0138934931567686,0.00646696295782602,"MAPK3/IKBKB/IL6/HIF1A/ICAM1/IL1B",6]
["GO:0002224","toll-like receptor signaling pathway","5/143","146/18670",0.00535042065998819,0.0141189718589519,0.00657191585903991,"TLR4/TLR9/IKBKB/ESR1/PTPN22",5]
["GO:0055123","digestive system development","5/143","146/18670",0.00535042065998819,0.0141189718589519,0.00657191585903991,"INSR/SHH/TNF/HIF1A/GLI2",5]
["GO:2000241","regulation of reproductive process","5/143","146/18670",0.00535042065998819,0.0141189718589519,0.00657191585903991,"AR/INSR/CNR1/ESR1/SHH",5]
["GO:0007411","axon guidance","7/143","276/18670",0.00543454918056013,0.0143316319758354,0.00667090213146074,"MAPK1/PIK3CA/MAPK3/PIK3R1/SHH/VEGFA/GLI2",7]
["GO:2000117","negative regulation of cysteine-type endopeptidase activity","4/143","92/18670",0.00547744947020205,0.014435361624595,0.00671918486270674,"PTGS2/MMP9/AKT1/VEGFA",4]
["GO:0043524","negative regulation of neuron apoptotic process","5/143","147/18670",0.00550541322515632,0.0144996179150506,0.00674909404720735,"PIK3CA/MTNR1B/HRAS/HMOX1/HIF1A",5]
["GO:0097485","neuron projection guidance","7/143","277/18670",0.00554060765344544,0.0145828217042569,0.0067878226676253,"MAPK1/PIK3CA/MAPK3/PIK3R1/SHH/VEGFA/GLI2",7]
["GO:0007622","rhythmic behavior","3/143","47/18670",0.0055770279176046,0.0146121741168048,0.00680148524783665,"MTOR/MTNR1B/TP53",3]
["GO:0018198","peptidyl-cysteine modification","3/143","47/18670",0.0055770279176046,0.0146121741168048,0.00680148524783665,"NOS2/ACE/GAPDH",3]
["GO:0045646","regulation of erythrocyte differentiation","3/143","47/18670",0.0055770279176046,0.0146121741168048,0.00680148524783665,"MAPK14/STAT3/HIF1A",3]
["GO:0070231","T cell apoptotic process","3/143","47/18670",0.0055770279176046,0.0146121741168048,0.00680148524783665,"AKT1/HIF1A/TP53",3]
["GO:0070849","response to epidermal growth factor","3/143","47/18670",0.0055770279176046,0.0146121741168048,0.00680148524783665,"MAPK1/MAPK3/AKT1",3]
["GO:1900744","regulation of p38MAPK cascade","3/143","47/18670",{"v":0.0055770279176046,"d":"5.58E-03"},{"v":0.0146121741168048,"d":"1.46E-02"},{"v":0.00680148524783665,"d":"6.80E-03"},"VEGFA/PTPN22/IL1B",3]
["GO:2000107","negative regulation of leukocyte apoptotic process","3/143","47/18670",{"v":0.0055770279176046,"d":"5.58E-03"},{"v":0.0146121741168048,"d":"1.46E-02"},{"v":0.00680148524783665,"d":"6.80E-03"},"IL2/HIF1A/CCR5",3]
["GO:0007589","body fluid secretion","4/143","93/18670",{"v":0.00569019494300177,"d":"5.69E-03"},{"v":0.0148494124696533,"d":"1.48E-02"},{"v":0.00691191187868719,"d":"6.91E-03"},"VDR/HK2/VEGFA/HIF1A",4]
["GO:0072080","nephron tubule development","4/143","93/18670",{"v":0.00569019494300177,"d":"5.69E-03"},{"v":0.0148494124696533,"d":"1.48E-02"},{"v":0.00691191187868719,"d":"6.91E-03"},"SHH/VEGFA/FGF2/PGF",4]
["GO:0006000","fructose metabolic process","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},{"v":0.0148494124696533,"d":"1.48E-02"},{"v":0.00691191187868719,"d":"6.91E-03"},"AKR1B1/SORD",2]
["GO:0010759","positive regulation of macrophage chemotaxis","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},{"v":0.0148494124696533,"d":"1.48E-02"},{"v":0.00691191187868719,"d":"6.91E-03"},"MAPK14/MAPK3",2]
["GO:0030238","male sex determination","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},{"v":0.0148494124696533,"d":"1.48E-02"},{"v":0.00691191187868719,"d":"6.91E-03"},"AR/INSR",2]
["GO:0032645","regulation of granulocyte macrophage colony-stimulating factor production","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},{"v":0.0148494124696533,"d":"1.48E-02"},{"v":0.00691191187868719,"d":"6.91E-03"},"TLR9/IL1B",2]
["GO:0034349","glial cell apoptotic process","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},0.0148494124696533,{"v":0.00691191187868719,"d":"6.91E-03"},"CASP3/TP53",2]
["GO:0045342","MHC class II biosynthetic process","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},0.0148494124696533,{"v":0.00691191187868719,"d":"6.91E-03"},"TLR4/SIRT1",2]
["GO:0045838","positive regulation of membrane potential","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},0.0148494124696533,{"v":0.00691191187868719,"d":"6.91E-03"},"AKT1/AKT2",2]
["GO:0045898","regulation of RNA polymerase II transcriptional preinitiation complex assembly","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},0.0148494124696533,{"v":0.00691191187868719,"d":"6.91E-03"},"ESR1/TP53",2]
["GO:0048368","lateral mesoderm development","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},0.0148494124696533,{"v":0.00691191187868719,"d":"6.91E-03"},"FGFR1/SHH",2]
["GO:0051044","positive regulation of membrane protein ectodomain proteolysis","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},0.0148494124696533,{"v":0.00691191187868719,"d":"6.91E-03"},"TNF/IL1B",2]
["GO:0051883","killing of cells in other organism involved in symbiotic interaction","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},0.0148494124696533,{"v":0.00691191187868719,"d":"6.91E-03"},"F2/GAPDH",2]
["GO:0055089","fatty acid homeostasis","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},0.0148494124696533,{"v":0.00691191187868719,"d":"6.91E-03"},"SIRT1/PRKAA2",2]
["GO:1900119","positive regulation of execution phase of apoptosis","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},0.0148494124696533,{"v":0.00691191187868719,"d":"6.91E-03"},"IL6/TP53",2]
["GO:1903350","response to dopamine","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},0.0148494124696533,{"v":0.00691191187868719,"d":"6.91E-03"},"MAPK1/MAPK3",2]
["GO:1903358","regulation of Golgi organization","2/143","15/18670",{"v":0.00572993633339884,"d":"5.73E-03"},0.0148494124696533,{"v":0.00691191187868719,"d":"6.91E-03"},"MAPK1/MAPK3",2]
["GO:0002706","regulation of lymphocyte mediated immunity","5/143","149/18670",{"v":0.00582487704914336,"d":"5.82E-03"},0.0150665190382954,{"v":0.00701296782778989,"d":"7.01E-03"},"IL2/TNF/IL6/PRKCZ/IL1B",5]
["GO:2000058","regulation of ubiquitin-dependent protein catabolic process","5/143","149/18670",{"v":0.00582487704914336,"d":"5.82E-03"},0.0150665190382954,{"v":0.00701296782778989,"d":"7.01E-03"},"GSK3B/AKT1/SHH/OGT/NFE2L2",5]
["GO:2001056","positive regulation of cysteine-type endopeptidase activity","5/143","149/18670",{"v":0.00582487704914336,"d":"5.82E-03"},0.0150665190382954,{"v":0.00701296782778989,"d":"7.01E-03"},"PPARG/ALOX12/TNF/SIRT1/EIF2AK3",5]
["GO:0044728","DNA methylation or demethylation","4/143","94/18670",{"v":0.00590838702972536,"d":"5.91E-03"},0.0152144052938146,{"v":0.00708180400351783,"d":"7.08E-03"},"PIK3CA/FOS/PRMT7/FTO",4]
["GO:0045621","positive regulation of lymphocyte differentiation","4/143","94/18670",{"v":0.00590838702972536,"d":"5.91E-03"},0.0152144052938146,0.00708180400351783,"IL2/SHH/PRKCZ/GLI2",4]
["GO:0060993","kidney morphogenesis","4/143","94/18670",{"v":0.00590838702972536,"d":"5.91E-03"},0.0152144052938146,0.00708180400351783,"SHH/VEGFA/FGF2/PGF",4]
["GO:0001774","microglial cell activation","3/143","48/18670",{"v":0.00591587794774314,"d":"5.92E-03"},0.0152144052938146,0.00708180400351783,"NAMPT/TNF/IL6",3]
["GO:0002269","leukocyte activation involved in inflammatory response","3/143","48/18670",{"v":0.00591587794774314,"d":"5.92E-03"},0.0152144052938146,0.00708180400351783,"NAMPT/TNF/IL6",3]
["GO:0002711","positive regulation of T cell mediated immunity","3/143","48/18670",{"v":0.00591587794774314,"d":"5.92E-03"},0.0152144052938146,0.00708180400351783,"IL6/PRKCZ/IL1B",3]
["GO:0045933","positive regulation of muscle contraction","3/143","48/18670",{"v":0.00591587794774314,"d":"5.92E-03"},0.0152144052938146,0.00708180400351783,"PTGS2/KCNQ1/ATP2A1",3]
["GO:0060324","face development","3/143","48/18670",{"v":0.00591587794774314,"d":"5.92E-03"},0.0152144052938146,0.00708180400351783,"MAPK1/MAPK3/MMP2",3]
["GO:0090199","regulation of release of cytochrome c from mitochondria","3/143","48/18670",{"v":0.00591587794774314,"d":"5.92E-03"},0.0152144052938146,0.00708180400351783,"MMP9/AKT1/TP53",3]
["GO:0016331","morphogenesis of embryonic epithelium","5/143","150/18670",{"v":0.00598941498592899,"d":"5.99E-03"},0.0153839796085283,0.00716073525568587,"AR/CASP3/SHH/HIF1A/GLI2",5]
["GO:0071774","response to fibroblast growth factor","5/143","150/18670",{"v":0.00598941498592899,"d":"5.99E-03"},0.0153839796085283,0.00716073525568587,"MAPK1/FGFR1/MAPK3/FGF2/CASR",5]
["GO:0042100","B cell proliferation","4/143","95/18670",{"v":0.006132085755527,"d":"6.13E-03"},0.0156906973061778,0.00730350223061636,"TLR4/TLR9/CASP3/IL2",4]
["GO:0042102","positive regulation of T cell proliferation","4/143","95/18670",0.006132085755527,0.0156906973061778,0.00730350223061636,"IL2/SHH/IL6/IL1B",4]
["GO:0042116","macrophage activation","4/143","95/18670",0.006132085755527,0.0156906973061778,0.00730350223061636,"TLR4/NAMPT/TNF/IL6",4]
["GO:0051651","maintenance of location in cell","4/143","95/18670",0.006132085755527,0.0156906973061778,0.00730350223061636,"AKT1/HK2/HK1/ATP2A1",4]
["GO:0055006","cardiac cell development","4/143","95/18670",0.006132085755527,0.0156906973061778,0.00730350223061636,"MTOR/PPARA/VEGFA/PARP2",4]
["GO:0061326","renal tubule development","4/143","95/18670",0.006132085755527,0.0156906973061778,0.00730350223061636,"SHH/VEGFA/FGF2/PGF",4]
["GO:0045732","positive regulation of protein catabolic process","6/143","214/18670",0.006158582884435,0.0157485429666411,0.00733042747823163,"GSK3B/AKT1/TNF/FOXO1/NFE2L2/IL1B",6]
["GO:0016579","protein deubiquitination","7/143","283/18670",0.0062099207444044,0.0158697974579224,0.00738686744582927,"AR/ESR1/CFTR/HIF1A/OGT/ADRB2/TP53",7]
["GO:0002686","negative regulation of leukocyte migration","3/143","49/18670",0.00626680235732062,0.0159346833809258,0.00741706970352017,"AKT1/CYP19A1/HMOX1",3]
["GO:0010712","regulation of collagen metabolic process","3/143","49/18670",0.00626680235732062,0.0159346833809258,0.00741706970352017,"F2/PPARG/IL6",3]
["GO:0030857","negative regulation of epithelial cell differentiation","3/143","49/18670",0.00626680235732062,0.0159346833809258,0.00741706970352017,"GSK3B/MMP9/VEGFA",3]
["GO:0048546","digestive tract morphogenesis","3/143","49/18670",0.00626680235732062,0.0159346833809258,0.00741706970352017,"SHH/HIF1A/GLI2",3]
["GO:0061912","selective autophagy","3/143","49/18670",0.00626680235732062,0.0159346833809258,0.00741706970352017,"MAPK3/ADRB2/TP53",3]
["GO:0071715","icosanoid transport","3/143","49/18670",0.00626680235732062,0.0159346833809258,0.00741706970352017,"NOS2/ACE/IL1B",3]
["GO:0097300","programmed necrotic cell death","3/143","49/18670",0.00626680235732062,0.0159346833809258,0.00741706970352017,"TLR4/TNF/TP53",3]
["GO:1901571","fatty acid derivative transport","3/143","49/18670",0.00626680235732062,0.0159346833809258,0.00741706970352017,"NOS2/ACE/IL1B",3]
["GO:0042632","cholesterol homeostasis","4/143","96/18670",0.00636135044178339,0.0161649382224351,0.00752424574010788,"FABP4/HNF4A/SIRT1/CETP",4]
["GO:0045807","positive regulation of endocytosis","5/143","153/18670",0.00650265029307448,0.0163825340298234,0.00762552941371541,"PPARG/TNF/VEGFA/SERPINE1/IL1B",5]
["GO:0001780","neutrophil homeostasis","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"IL6/HCAR2",2]
["GO:0002830","positive regulation of type 2 immune response","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"IL6/PRKCZ",2]
["GO:0006206","pyrimidine nucleobase metabolic process","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"MAPK1/MTOR",2]
["GO:0010875","positive regulation of cholesterol efflux","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"PON1/SIRT1",2]
["GO:0010885","regulation of cholesterol storage","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"PPARG/PPARA",2]
["GO:0010934","macrophage cytokine production","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"TLR4/SIRT1",2]
["GO:0032604","granulocyte macrophage colony-stimulating factor production","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"TLR9/IL1B",2]
["GO:0034116","positive regulation of heterotypic cell-cell adhesion","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"TNF/IL1B",2]
["GO:0042447","hormone catabolic process","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"CYP19A1/ACE",2]
["GO:0043217","myelin maintenance","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"AKT1/AKT2",2]
["GO:0045986","negative regulation of smooth muscle contraction","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"PTGS2/ADRB2",2]
["GO:0045989","positive regulation of striated muscle contraction","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"KCNQ1/ATP2A1",2]
["GO:0070293","renal absorption","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"KCNQ1/SGK1",2]
["GO:1902004","positive regulation of amyloid-beta formation","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"CASP3/TNF",2]
["GO:2000846","regulation of corticosteroid hormone secretion","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"REN/AGTR1",2]
["GO:2001170","negative regulation of ATP biosynthetic process","2/143","16/18670",0.00651578058004342,0.0163825340298234,0.00762552941371541,"STAT3/PPARA",2]
["GO:0048709","oligodendrocyte differentiation","4/143","97/18670",0.00659623969682315,0.0165642545240323,0.00771011431194557,"MTOR/PPARG/HDAC11/SHH",4]
["GO:0055092","sterol homeostasis","4/143","97/18670",0.00659623969682315,0.0165642545240323,0.00771011431194557,"FABP4/HNF4A/SIRT1/CETP",4]
["GO:0010718","positive regulation of epithelial to mesenchymal transition","3/143","50/18670",0.00662990906098128,0.0165768201845906,0.00771596321261109,"MTOR/IL6/IL1B",3]
["GO:0032873","negative regulation of stress-activated MAPK cascade","3/143","50/18670",0.00662990906098128,0.0165768201845906,0.00771596321261109,"AKT1/FOXO1/PTPN22",3]
["GO:0046854","phosphatidylinositol phosphorylation","3/143","50/18670",0.00662990906098128,0.0165768201845906,0.00771596321261109,"PIK3CA/PIK3CG/PIK3R1",3]
["GO:0070303","negative regulation of stress-activated protein kinase signaling cascade","3/143","50/18670",0.00662990906098128,0.0165768201845906,0.00771596321261109,"AKT1/FOXO1/PTPN22",3]
["GO:0070741","response to interleukin-6","3/143","50/18670",0.00662990906098128,0.0165768201845906,0.00771596321261109,"STAT3/IL6/ICAM1",3]
["GO:1903793","positive regulation of anion transport","3/143","50/18670",0.00662990906098128,0.0165768201845906,0.00771596321261109,"AVPR1A/CFTR/IL1B",3]
["GO:2000725","regulation of cardiac muscle cell differentiation","3/143","50/18670",0.00662990906098128,0.0165768201845906,0.00771596321261109,"MTOR/PPARA/PARP2",3]
["GO:0048562","embryonic organ morphogenesis","7/143","288/18670",0.00681237018441417,0.0170120138843359,0.00791853153031031,"MAPK1/FGFR1/MAPK3/SHH/HIF1A/GLI2/RBP4",7]
["GO:0098656","anion transmembrane transport","7/143","288/18670",0.00681237018441417,0.0170120138843359,0.00791853153031031,"MTOR/AKT1/CFTR/AKT2/CASR/PRKAA2/ACACB",7]
["GO:0006885","regulation of pH","4/143","98/18670",0.00683681140704887,0.0170625231662971,0.00794204193563338,"MAPK1/MAPK3/AVPR1A/CFTR",4]
["GO:0060968","regulation of gene silencing","5/143","155/18670",0.00686148685296202,0.0171030164906344,0.00796089024293623,"STAT3/ESR1/PPARG/SIRT1/TP53",5]
["GO:1903707","negative regulation of hemopoiesis","5/143","155/18670",0.00686148685296202,0.0171030164906344,0.00796089024293623,"TLR4/PIK3R1/IL2/SHH/NFE2L2",5]
["GO:0043583","ear development","6/143","219/18670",0.00687022098993657,0.0171142489644697,0.00796611858914103,"MAPK1/FGFR1/MAPK3/KCNQ1/SHH/GLI2",6]
["GO:0001954","positive regulation of cell-matrix adhesion","3/143","51/18670",0.00700530132980338,0.0174078942805673,0.00810280080149143,"GSK3B/VEGFA/PRKCZ",3]
["GO:0019369","arachidonic acid metabolic process","3/143","51/18670",0.00700530132980338,0.0174078942805673,0.00810280080149143,"PTGS2/MAPK3/ALOX12",3]
["GO:0032007","negative regulation of TOR signaling","3/143","51/18670",0.00700530132980338,0.0174078942805673,0.00810280080149143,"SIRT1/HIF1A/PRKAA2",3]
["GO:0048641","regulation of skeletal muscle tissue development","3/143","51/18670",0.00700530132980338,0.0174078942805673,0.00810280080149143,"HMGCR/SHH/CYP26B1",3]
["GO:0042129","regulation of T cell proliferation","5/143","156/18670",0.00704600681046637,0.0174983040299189,0.00814488355875673,"CASP3/IL2/SHH/IL6/IL1B",5]
["GO:0070301","cellular response to hydrogen peroxide","4/143","99/18670",0.00708312272844377,0.0175796939330107,0.00818276787499716,"SIRT1/IL6/FOXO1/NFE2L2",4]
["GO:0060079","excitatory postsynaptic potential","4/143","100/18670",0.00733523007845584,0.0180044809350706,0.00838049221806126,"GSK3B/AKT1/PRKCZ/ADRB2",4]
["GO:0070498","interleukin-1-mediated signaling pathway","4/143","100/18670",0.00733523007845584,0.0180044809350706,0.00838049221806126,"MAPK3/IKBKB/IL6/IL1B",4]
["GO:0006089","lactate metabolic process","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"HIF1A/TP53",2]
["GO:0010715","regulation of extracellular matrix disassembly","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"DPP4/IL6",2]
["GO:0015732","prostaglandin transport","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"NOS2/IL1B",2]
["GO:0032740","positive regulation of interleukin-17 production","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"IL2/IL6",2]
["GO:0032966","negative regulation of collagen biosynthetic process","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"PPARG/IL6",2]
["GO:0035930","corticosteroid hormone secretion","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"REN/AGTR1",2]
["GO:0042953","lipoprotein transport","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"PRKCB/PPARG",2]
["GO:0044872","lipoprotein localization","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"PRKCB/PPARG",2]
["GO:0045721","negative regulation of gluconeogenesis","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"GCK/CLK2",2]
["GO:0051709","regulation of killing of cells of other organism","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"NOS2/GAPDH",2]
["GO:0051818","disruption of cells of other organism involved in symbiotic interaction","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"F2/GAPDH",2]
["GO:0051969","regulation of transmission of nerve impulse","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"MTNR1B/AVPR1A",2]
["GO:0070166","enamel mineralization","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"PPARA/FOXO1",2]
["GO:0070242","thymocyte apoptotic process","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"HIF1A/TP53",2]
["GO:0090185","negative regulation of kidney development","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"MMP9/SHH",2]
["GO:1902683","regulation of receptor localization to synapse","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"HRAS/PRKCZ",2]
["GO:1904355","positive regulation of telomere capping","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"MAPK1/MAPK3",2]
["GO:1904996","positive regulation of leukocyte adhesion to vascular endothelial cell","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"TNF/ICAM1",2]
["GO:2000641","regulation of early endosome to late endosome transport","2/143","17/18670",0.0073476784843717,0.0180044809350706,0.00838049221806126,"MAPK1/MAPK3",2]
["GO:0031529","ruffle organization","3/143","52/18670",0.00739307787199448,0.0180719681315421,0.0084119052827804,"MTOR/HRAS/ICAM1",3]
["GO:0032653","regulation of interleukin-10 production","3/143","52/18670",0.00739307787199448,0.0180719681315421,0.0084119052827804,"TLR4/TLR9/PRKCZ",3]
["GO:0055078","sodium ion homeostasis","3/143","52/18670",0.00739307787199448,0.0180719681315421,0.0084119052827804,"AVPR2/AVPR1A/AGTR1",3]
["GO:2000772","regulation of cellular senescence","3/143","52/18670",0.00739307787199448,0.0180719681315421,0.0084119052827804,"NAMPT/SIRT1/TP53",3]
["GO:0000186","activation of MAPKK activity","3/143","53/18670",0.00779333291251824,0.0189587810275684,0.00882468744522246,"MAPK1/MAPK3/MAP3K9",3]
["GO:0002043","blood vessel endothelial cell proliferation involved in sprouting angiogenesis","3/143","53/18670",0.00779333291251824,0.0189587810275684,0.00882468744522246,"VEGFA/HMOX1/AGTR1",3]
["GO:0032964","collagen biosynthetic process","3/143","53/18670",0.00779333291251824,0.0189587810275684,0.00882468744522246,"F2/PPARG/IL6",3]
["GO:0035065","regulation of histone acetylation","3/143","53/18670",0.00779333291251824,0.0189587810275684,0.00882468744522246,"MAPK3/SIRT1/IL1B",3]
["GO:0045661","regulation of myoblast differentiation","3/143","53/18670",0.00779333291251824,0.0189587810275684,0.00882468744522246,"MAPK14/TNF/IGFBP3",3]
["GO:0070228","regulation of lymphocyte apoptotic process","3/143","53/18670",0.00779333291251824,0.0189587810275684,0.00882468744522246,"IL2/HIF1A/TP53",3]
["GO:0071320","cellular response to cAMP","3/143","53/18670",0.00779333291251824,0.0189587810275684,0.00882468744522246,"PIK3CG/KCNQ1/CFTR",3]
["GO:1905517","macrophage migration","3/143","53/18670",0.00779333291251824,0.0189587810275684,0.00882468744522246,"MAPK14/MAPK3/CYP19A1",3]
["GO:0001649","osteoblast differentiation","6/143","225/18670",0.00780082482661653,0.0189656089478341,0.00882786561697082,"AKT1/SHH/TNF/IGFBP3/IL6/GLI2",6]
["GO:0007519","skeletal muscle tissue development","5/143","160/18670",0.00781884919440716,0.0189980201314287,0.00884295195424832,"MAPK14/HMGCR/SHH/FOS/CYP26B1",5]
["GO:1902106","negative regulation of leukocyte differentiation","4/143","103/18670",0.00812688123651541,0.0197346222228041,0.00918581593998837,"TLR4/PIK3R1/IL2/SHH",4]
["GO:0032655","regulation of interleukin-12 production","3/143","54/18670",0.00820615627166518,0.0198416859145204,0.00923565055829818,"TLR4/MAPK14/TLR9",3]
["GO:0097345","mitochondrial outer membrane permeabilization","3/143","54/18670",0.00820615627166518,0.0198416859145204,0.00923565055829818,"GSK3B/MAPK8/TP53",3]
["GO:0006349","regulation of gene expression by genetic imprinting","2/143","18/18670",0.00822488857820286,0.0198416859145204,0.00923565055829818,"KCNQ1/PRMT7",2]
["GO:0010713","negative regulation of collagen metabolic process","2/143","18/18670",0.00822488857820286,0.0198416859145204,0.00923565055829818,"PPARG/IL6",2]
["GO:0010878","cholesterol storage","2/143","18/18670",0.00822488857820286,0.0198416859145204,0.00923565055829818,"PPARG/PPARA",2]
["GO:0030809","negative regulation of nucleotide biosynthetic process","2/143","18/18670",0.00822488857820286,0.0198416859145204,0.00923565055829818,"STAT3/PPARA",2]
["GO:0031065","positive regulation of histone deacetylation","2/143","18/18670",0.00822488857820286,0.0198416859145204,0.00923565055829818,"VEGFA/TP53",2]
["GO:0035994","response to muscle stretch","2/143","18/18670",0.00822488857820286,0.0198416859145204,0.00923565055829818,"MAPK14/FOS",2]
["GO:1900221","regulation of amyloid-beta clearance","2/143","18/18670",0.00822488857820286,0.0198416859145204,0.00923565055829818,"HMGCR/TNF",2]
["GO:1900372","negative regulation of purine nucleotide biosynthetic process","2/143","18/18670",0.00822488857820286,0.0198416859145204,0.00923565055829818,"STAT3/PPARA",2]
["GO:2000479","regulation of cAMP-dependent protein kinase activity","2/143","18/18670",0.00822488857820286,0.0198416859145204,0.00923565055829818,"SIRT1/ADRB2",2]
["GO:0070646","protein modification by small protein removal","7/143","299/18670",0.00828972086031964,0.0199861763207706,0.00930290607816192,"AR/ESR1/CFTR/HIF1A/OGT/ADRB2/TP53",7]
["GO:0032414","positive regulation of ion transmembrane transporter activity","4/143","104/18670",0.00840272184123445,0.0202465583412602,0.00942410532318902,"CFTR/KCNJ11/ADRB2/ATP2A1",4]
["GO:0001541","ovarian follicle development","3/143","55/18670",0.00863163344257929,0.0207487245698105,0.00965784714477867,"ESR1/VEGFA/ICAM1",3]
["GO:0032613","interleukin-10 production","3/143","55/18670",0.00863163344257929,0.0207487245698105,0.00965784714477867,"TLR4/TLR9/PRKCZ",3]
["GO:0043551","regulation of phosphatidylinositol 3-kinase activity","3/143","55/18670",0.00863163344257929,0.0207487245698105,0.00965784714477867,"FLT1/PIK3R1/FGF2",3]
["GO:0097120","receptor localization to synapse","3/143","55/18670",0.00863163344257929,0.0207487245698105,0.00965784714477867,"MAPK10/HRAS/PRKCZ",3]
["GO:0032006","regulation of TOR signaling","4/143","105/18670",0.00868462922522521,0.0208513517815609,0.00970561672794725,"PIK3CA/SIRT1/HIF1A/PRKAA2",4]
["GO:0043266","regulation of potassium ion transport","4/143","105/18670",0.00868462922522521,0.0208513517815609,0.00970561672794725,"GCK/MTNR1B/KCNQ1/NOS3",4]
["GO:1903320","regulation of protein modification by small protein conjugation or removal","6/143","231/18670",0.00881916447207231,0.021161812556579,0.00985012598197325,"MTOR/AKT1/AVPR2/PTPN22/OGT/ADRB2",6]
["GO:0050680","negative regulation of epithelial cell proliferation","5/143","165/18670",0.00886549494841885,0.0212603812507106,0.00989600645901082,"AR/FLT1/VDR/PPARG/TNF",5]
["GO:0002456","T cell mediated immunity","4/143","106/18670",0.00897265522451147,0.0214791888520535,0.009997854182748,"IL6/PRKCZ/ICAM1/IL1B",4]
["GO:0003300","cardiac muscle hypertrophy","4/143","106/18670",0.00897265522451147,0.0214791888520535,0.009997854182748,"MTOR/PPARA/FOXO1/PARP2",4]
["GO:0021510","spinal cord development","4/143","106/18670",0.00897265522451147,0.0214791888520535,0.009997854182748,"MTOR/AKT1/SHH/GLI2",4]
["GO:0032615","interleukin-12 production","3/143","56/18670",0.00906984566775282,0.0216271916964288,0.0100667446267442,"TLR4/MAPK14/TLR9",3]
["GO:0090183","regulation of kidney development","3/143","56/18670",0.00906984566775282,0.0216271916964288,0.0100667446267442,"MMP9/SHH/VEGFA",3]
["GO:0001696","gastric acid secretion","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"KCNQ1/SGK1",2]
["GO:0001991","regulation of systemic arterial blood pressure by circulatory renin-angiotensin","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"REN/ACE",2]
["GO:0002076","osteoblast development","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"SHH/GLI2",2]
["GO:0002544","chronic inflammatory response","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"CYP19A1/TNF",2]
["GO:0002922","positive regulation of humoral immune response","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"TNF/IL1B",2]
["GO:0003085","negative regulation of systemic arterial blood pressure","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"ADRB3/ADRB2",2]
["GO:0007625","grooming behavior","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"AVPR1A/MC4R",2]
["GO:0010663","positive regulation of striated muscle cell apoptotic process","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"HMGCR/TP53",2]
["GO:0010666","positive regulation of cardiac muscle cell apoptotic process","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"HMGCR/TP53",2]
["GO:0032095","regulation of response to food","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"MTOR/PPARA",2]
["GO:0033189","response to vitamin A","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"PPARG/CYP26B1",2]
["GO:0042789","mRNA transcription by RNA polymerase II","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"STAT3/HIF1A",2]
["GO:0051546","keratinocyte migration","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"MMP9/MTOR",2]
["GO:0060716","labyrinthine layer blood vessel development","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"MAPK1/AKT1",2]
["GO:0070989","oxidative demethylation","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"CYP3A4/FTO",2]
["GO:1900409","positive regulation of cellular response to oxidative stress","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"TLR4/TNF",2]
["GO:1903798","regulation of production of miRNAs involved in gene silencing by miRNA","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"ESR1/TP53",2]
["GO:2000010","positive regulation of protein localization to cell surface","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"AKT1/TNF",2]
["GO:2000831","regulation of steroid hormone secretion","2/143","19/18670",0.00914667791113787,0.0216271916964288,0.0100667446267442,"REN/AGTR1",2]
["GO:0048588","developmental cell growth","6/143","234/18670",0.00936258725784234,0.0221247829654091,0.010298356955503,"GSK3B/MTOR/PPARA/VEGFA/PRKCZ/PARP2",6]
["GO:0010665","regulation of cardiac muscle cell apoptotic process","3/143","57/18670",0.00952087001450094,0.0224202919247817,0.0104359066323485,"HMGCR/TP53/NFE2L2",3]
["GO:0043525","positive regulation of neuron apoptotic process","3/143","57/18670",0.00952087001450094,0.0224202919247817,0.0104359066323485,"CASP3/TNF/TP53",3]
["GO:0048008","platelet-derived growth factor receptor signaling pathway","3/143","57/18670",0.00952087001450094,0.0224202919247817,0.0104359066323485,"PTPN1/PLAT/VEGFA",3]
["GO:0060760","positive regulation of response to cytokine stimulus","3/143","57/18670",0.00952087001450094,0.0224202919247817,0.0104359066323485,"TLR4/AGPAT2/HIF1A",3]
["GO:0061178","regulation of insulin secretion involved in cellular response to glucose stimulus","3/143","57/18670",0.00952087001450094,0.0224202919247817,0.0104359066323485,"HMGCR/CFTR/HIF1A",3]
["GO:0071398","cellular response to fatty acid","3/143","57/18670",0.00952087001450094,0.0224202919247817,0.0104359066323485,"AKT1/PPARG/PRKAA2",3]
["GO:0051302","regulation of cell division","5/143","168/18670",0.00953795804312605,0.0224474733480083,0.0104485586886142,"SHH/VEGFA/FGF2/PGF/IL1B",5]
["GO:0008544","epidermis development","9/143","464/18670",0.00954361525518517,0.0224477365212025,0.0104486811870586,"FGFR1/INSR/VDR/CASP3/PPARA/SHH/TNF/AGPAT2/CYP26B1",9]
["GO:0006275","regulation of DNA replication","4/143","108/18670",0.00956726648079659,0.0224642080709191,0.0104563481503394,"FGFR1/HRAS/GLI2/TP53",4]
["GO:0030004","cellular monovalent inorganic cation homeostasis","4/143","108/18670",0.00956726648079659,0.0224642080709191,0.0104563481503394,"MAPK1/MAPK3/AVPR1A/CFTR",4]
["GO:0099565","chemical synaptic transmission, postsynaptic","4/143","108/18670",0.00956726648079659,0.0224642080709191,0.0104563481503394,"GSK3B/AKT1/PRKCZ/ADRB2",4]
["GO:0018394","peptidyl-lysine acetylation","5/143","169/18670",0.00976970782964005,0.022899697333169,0.010659054042639,"MAPK3/SIRT1/OGT/PRKAA2/IL1B",5]
["GO:0050728","negative regulation of inflammatory response","5/143","169/18670",0.00976970782964005,0.022899697333169,0.010659054042639,"F2/CYP19A1/PPARG/PPARA/IL2",5]
["GO:0060538","skeletal muscle organ development","5/143","169/18670",0.00976970782964005,0.022899697333169,0.010659054042639,"MAPK14/HMGCR/SHH/FOS/CYP26B1",5]
["GO:0014897","striated muscle hypertrophy","4/143","109/18670",0.00987395146183232,0.0231172675057821,0.0107603257841039,"MTOR/PPARA/FOXO1/PARP2",4]
["GO:0072009","nephron epithelium development","4/143","109/18670",0.00987395146183232,0.0231172675057821,0.0107603257841039,"SHH/VEGFA/FGF2/PGF",4]
["GO:0043433","negative regulation of DNA-binding transcription factor activity","5/143","170/18670",0.0100053052518036,0.0234112576065324,0.0108971684823416,"TLR9/ESR1/SIRT1/HMOX1/NR0B2",5]
["GO:0003323","type B pancreatic cell development","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"GSK3B/HNF4A",2]
["GO:0006525","arginine metabolic process","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"NOS2/NOS3",2]
["GO:0007620","copulation","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"CNR1/AVPR1A",2]
["GO:0010042","response to manganese ion","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"PTGS2/EIF2AK3",2]
["GO:0032495","response to muramyl dipeptide","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"MAPK14/PTPN22",2]
["GO:0060261","positive regulation of transcription initiation from RNA polymerase II promoter","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"ESR1/TP53",2]
["GO:0060602","branch elongation of an epithelium","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"ESR1/SHH",2]
["GO:0070932","histone H3 deacetylation","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"HDAC11/SIRT1",2]
["GO:0097062","dendritic spine maintenance","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"IGF1R/INSR",2]
["GO:1902993","positive regulation of amyloid precursor protein catabolic process","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"CASP3/TNF",2]
["GO:1903599","positive regulation of autophagy of mitochondrion","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"HK2/HIF1A",2]
["GO:1905523","positive regulation of macrophage migration","2/143","20/18670",0.0101123219650757,0.0234986678040336,0.010937855047124,"MAPK14/MAPK3",2]
["GO:0006937","regulation of muscle contraction","5/143","171/18670",0.0102447799431681,0.0237928107917066,0.0110747689091832,"PTGS2/PIK3CG/KCNQ1/ADRB2/ATP2A1",5]
["GO:0001836","release of cytochrome c from mitochondria","3/143","59/18670",0.0104616429118967,0.0242547139217399,0.0112897695859981,"MMP9/AKT1/TP53",3]
["GO:0010662","regulation of striated muscle cell apoptotic process","3/143","59/18670",0.0104616429118967,0.0242547139217399,0.0112897695859981,"HMGCR/TP53/NFE2L2",3]
["GO:0033619","membrane protein proteolysis","3/143","59/18670",0.0104616429118967,0.0242547139217399,0.0112897695859981,"BACE2/TNF/IL1B",3]
["GO:0014896","muscle hypertrophy","4/143","111/18670",0.0105063234434183,0.0243443602169188,0.0113314969805192,"MTOR/PPARA/FOXO1/PARP2",4]
["GO:0050868","negative regulation of T cell activation","4/143","112/18670",0.0108321053523184,0.0250848755527373,0.0116761824525171,"CASP3/IL2/SHH/PTPN22",4]
["GO:0070588","calcium ion transmembrane transport","7/143","315/18670",0.0108435031108148,0.0250969128602506,0.0116817854222614,"TLR9/PIK3CG/F2/FGF2/TRPM6/CCR5/ATP2A1",7]
["GO:0010659","cardiac muscle cell apoptotic process","3/143","60/18670",0.0109515253865136,0.0252746720436756,0.011764526460937,"HMGCR/TP53/NFE2L2",3]
["GO:0032515","negative regulation of phosphoprotein phosphatase activity","3/143","60/18670",0.0109515253865136,0.0252746720436756,0.011764526460937,"GSK3B/IKBKB/TNF",3]
["GO:0045576","mast cell activation","3/143","60/18670",0.0109515253865136,0.0252746720436756,0.011764526460937,"PIK3CG/CNR1/HMOX1",3]
["GO:0090342","regulation of cell aging","3/143","60/18670",0.0109515253865136,0.0252746720436756,0.011764526460937,"NAMPT/SIRT1/TP53",3]
["GO:1902110","positive regulation of mitochondrial membrane permeability involved in apoptotic process","3/143","60/18670",0.0109515253865136,0.0252746720436756,0.011764526460937,"GSK3B/MAPK8/TP53",3]
["GO:0006941","striated muscle contraction","5/143","174/18670",0.0109867606535415,0.0253415425216728,0.0117956524635413,"PIK3CA/PIK3CG/MTOR/KCNQ1/ATP2A1",5]
["GO:0002438","acute inflammatory response to antigenic stimulus","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"CNR1/ICAM1",2]
["GO:0010893","positive regulation of steroid biosynthetic process","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"TNF/IL1B",2]
["GO:0032891","negative regulation of organic acid transport","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"AKT1/AKT2",2]
["GO:0035162","embryonic hemopoiesis","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"VEGFA/HIF1A",2]
["GO:0035357","peroxisome proliferator activated receptor signaling pathway","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"PPARG/SIRT1",2]
["GO:0043984","histone H4-K16 acetylation","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"SIRT1/OGT",2]
["GO:0051412","response to corticosterone","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"AVPR1A/FOS",2]
["GO:0055093","response to hyperoxia","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"PPARG/FOXO1",2]
["GO:0070920","regulation of production of small RNA involved in gene silencing by RNA","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"ESR1/TP53",2]
["GO:0071498","cellular response to fluid shear stress","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"PTGS2/NFE2L2",2]
["GO:0090280","positive regulation of calcium ion import","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"CASR/ATP2A1",2]
["GO:1902473","regulation of protein localization to synapse","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"HRAS/PRKCZ",2]
["GO:1902884","positive regulation of response to oxidative stress","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"TLR4/TNF",2]
["GO:2000380","regulation of mesoderm development","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"FGFR1/SHH",2]
["GO:2000737","negative regulation of stem cell differentiation","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"STAT3/NFE2L2",2]
["GO:2000810","regulation of bicellular tight junction assembly","2/143","21/18670",0.0111211045695253,0.0254196675874865,0.0118320171056794,"IKBKB/TNF",2]
["GO:0043244","regulation of protein complex disassembly","4/143","113/18670",0.0111643464599212,0.0254897205131196,0.0118646244327242,"IGF1R/INSR/TNF/ADRB2",4]
["GO:0060964","regulation of gene silencing by miRNA","4/143","113/18670",0.0111643464599212,0.0254897205131196,0.0118646244327242,"STAT3/ESR1/PPARG/TP53",4]
["GO:0010921","regulation of phosphatase activity","5/143","175/18670",0.011242036312587,0.0256526285193643,0.0119404527381064,"GSK3B/MTOR/IKBKB/TNF/IGFBP3",5]
["GO:0016311","dephosphorylation","9/143","478/18670",0.0114337682974038,0.0260754332776847,0.0121372544120698,"GSK3B/MTOR/IKBKB/PTPN1/PON1/TNF/ACP1/IGFBP3/PTPN22",9]
["GO:0008543","fibroblast growth factor receptor signaling pathway","4/143","114/18670",0.0115030921865232,0.0262040051609712,0.0121971003843713,"MAPK1/FGFR1/MAPK3/FGF2",4]
["GO:0030282","bone mineralization","4/143","114/18670",0.0115030921865232,0.0262040051609712,0.0121971003843713,"PTGS2/HIF1A/EIF2AK3/ADRB2",4]
["GO:0006650","glycerophospholipid metabolic process","7/143","319/18670",0.0115626095599918,0.0263247713716798,0.0122533130734624,"PIK3CA/PIK3CG/PIK3R1/PON1/FGF2/AGPAT2/CETP",7]
["GO:0010658","striated muscle cell apoptotic process","3/143","62/18670",0.0119705879649341,0.0271315453986859,0.012628839781477,"HMGCR/TP53/NFE2L2",3]
["GO:0010830","regulation of myotube differentiation","3/143","62/18670",0.0119705879649341,0.0271315453986859,0.012628839781477,"MAPK14/MTOR/CYP26B1",3]
["GO:0031640","killing of cells of other organism","3/143","62/18670",0.0119705879649341,0.0271315453986859,0.012628839781477,"NOS2/F2/GAPDH",3]
["GO:0044364","disruption of cells of other organism","3/143","62/18670",0.0119705879649341,0.0271315453986859,0.012628839781477,"NOS2/F2/GAPDH",3]
["GO:0045453","bone resorption","3/143","62/18670",0.0119705879649341,0.0271315453986859,0.012628839781477,"IL6/ADRB2/MC4R",3]
["GO:0070265","necrotic cell death","3/143","62/18670",0.0119705879649341,0.0271315453986859,0.012628839781477,"TLR4/TNF/TP53",3]
["GO:1901862","negative regulation of muscle tissue development","3/143","62/18670",0.0119705879649341,0.0271315453986859,0.012628839781477,"PPARA/SHH/RBP4",3]
["GO:1902686","mitochondrial outer membrane permeabilization involved in programmed cell death","3/143","62/18670",0.0119705879649341,0.0271315453986859,0.012628839781477,"GSK3B/MAPK8/TP53",3]
["GO:0001759","organ induction","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"AR/FGFR1",2]
["GO:0021513","spinal cord dorsal/ventral patterning","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"SHH/GLI2",2]
["GO:0032069","regulation of nuclease activity","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"AKT1/SIRT1",2]
["GO:0032727","positive regulation of interferon-alpha production","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"TLR4/TLR9",2]
["GO:0035809","regulation of urine volume","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"AVPR2/AKR1B1",2]
["GO:0035929","steroid hormone secretion","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"REN/AGTR1",2]
["GO:0045663","positive regulation of myoblast differentiation","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"MAPK14/IGFBP3",2]
["GO:0045943","positive regulation of transcription by RNA polymerase I","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"MTOR/EIF2AK3",2]
["GO:0046628","positive regulation of insulin receptor signaling pathway","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"SIRT1/PRKCZ",2]
["GO:0071404","cellular response to low-density lipoprotein particle stimulus","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"PPARG/CASR",2]
["GO:0090312","positive regulation of protein deacetylation","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"VEGFA/TP53",2]
["GO:1901984","negative regulation of protein acetylation","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"GSK3B/SIRT1",2]
["GO:2000773","negative regulation of cellular senescence","2/143","22/18670",0.0121723178177054,0.0273894066292783,0.0127488656819243,"NAMPT/SIRT1",2]
["GO:0006661","phosphatidylinositol biosynthetic process","4/143","116/18670",0.0122002750762501,0.0274370630603668,0.0127710481792325,"PIK3CA/PIK3CG/PIK3R1/FGF2",4]
["GO:0051099","positive regulation of binding","5/143","179/18670",0.0123036410917164,0.027638811952979,0.0128649556365281,"GSK3B/MMP9/PPARG/PON1/ACE",5]
["GO:2001235","positive regulation of apoptotic signaling pathway","5/143","179/18670",0.0123036410917164,0.027638811952979,0.0128649556365281,"GSK3B/MAPK8/MMP9/SIRT1/TP53",5]
["GO:0035418","protein localization to synapse","3/143","63/18670",0.0124998789029608,0.0280329694178311,0.013048422939962,"MAPK10/HRAS/PRKCZ",3]
["GO:0042982","amyloid precursor protein metabolic process","3/143","63/18670",0.0124998789029608,0.0280329694178311,0.013048422939962,"BACE2/CASP3/TNF",3]
["GO:0046637","regulation of alpha-beta T cell differentiation","3/143","63/18670",0.0124998789029608,0.0280329694178311,0.013048422939962,"IL2/SHH/PRKCZ",3]
["GO:0060147","regulation of posttranscriptional gene silencing","4/143","117/18670",0.0125587989695579,0.0281339337181906,0.0130954184927089,"STAT3/ESR1/PPARG/TP53",4]
["GO:0060966","regulation of gene silencing by RNA","4/143","117/18670",0.0125587989695579,0.0281339337181906,0.0130954184927089,"STAT3/ESR1/PPARG/TP53",4]
["GO:1901796","regulation of signal transduction by p53 class mediator","5/143","180/18670",0.0125793073177349,0.0281642898352826,0.0131095482642906,"MAPK14/AKT1/SIRT1/TP53/PRKAA2",5]
["GO:0010951","negative regulation of endopeptidase activity","6/143","250/18670",0.0126713008078625,0.0283545747209659,0.0131981196043605,"PTGS2/MMP9/AKT1/VEGFA/SERPINE1/GAPDH",6]
["GO:0042471","ear morphogenesis","4/143","118/18670",0.0129240009370131,0.0289040639740491,0.0134538887335001,"MAPK1/FGFR1/MAPK3/GLI2",4]
["GO:0006360","transcription by RNA polymerase I","3/143","64/18670",0.0130424106598353,0.0291045635893126,0.0135472146933819,"MTOR/MAPK3/EIF2AK3",3]
["GO:0035773","insulin secretion involved in cellular response to glucose stimulus","3/143","64/18670",0.0130424106598353,0.0291045635893126,0.0135472146933819,"HMGCR/CFTR/HIF1A",3]
["GO:0035794","positive regulation of mitochondrial membrane permeability","3/143","64/18670",0.0130424106598353,0.0291045635893126,0.0135472146933819,"GSK3B/MAPK8/TP53",3]
["GO:0046834","lipid phosphorylation","3/143","64/18670",0.0130424106598353,0.0291045635893126,0.0135472146933819,"PIK3CA/PIK3CG/PIK3R1",3]
["GO:0006359","regulation of transcription by RNA polymerase III","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"AR/MTOR",2]
["GO:0007413","axonal fasciculation","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"CNR1/CASP3",2]
["GO:0007530","sex determination","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"AR/INSR",2]
["GO:0019400","alditol metabolic process","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"AKR1B1/SORD",2]
["GO:0030539","male genitalia development","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"AR/SHH",2]
["GO:0032373","positive regulation of sterol transport","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"PON1/SIRT1",2]
["GO:0032376","positive regulation of cholesterol transport","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"PON1/SIRT1",2]
["GO:0032717","negative regulation of interleukin-8 production","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"TLR9/PTPN22",2]
["GO:0034123","positive regulation of toll-like receptor signaling pathway","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"TLR9/PTPN22",2]
["GO:0051043","regulation of membrane protein ectodomain proteolysis","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"TNF/IL1B",2]
["GO:0051152","positive regulation of smooth muscle cell differentiation","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"SHH/SIRT1",2]
["GO:0051349","positive regulation of lyase activity","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"NOS2/NOS3",2]
["GO:0051570","regulation of histone H3-K9 methylation","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"SIRT1/SETD7",2]
["GO:0061436","establishment of skin barrier","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"ALOX12/CYP26B1",2]
["GO:0071305","cellular response to vitamin D","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"VDR/CASR",2]
["GO:0090343","positive regulation of cell aging","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"SIRT1/TP53",2]
["GO:0106030","neuron projection fasciculation","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"CNR1/CASP3",2]
["GO:2000637","positive regulation of gene silencing by miRNA","2/143","23/18670",0.013265261983426,0.0293110155616313,0.0136433112792074,"STAT3/TP53",2]
["GO:0007173","epidermal growth factor receptor signaling pathway","4/143","119/18670",0.0132959222728385,0.0293627350575287,0.0136673849992137,"MMP9/PIK3CA/AKT1/PIK3R1",4]
["GO:0061136","regulation of proteasomal protein catabolic process","5/143","183/18670",0.0134313795428902,0.0296457057740565,0.0137990985374353,"GSK3B/AKT1/SHH/OGT/NFE2L2",5]
["GO:0002548","monocyte chemotaxis","3/143","65/18670",0.0135982294999566,0.029932372493651,0.013932532443217,"FLT1/SERPINE1/IL6",3]
["GO:0014823","response to activity","3/143","65/18670",0.0135982294999566,0.029932372493651,0.013932532443217,"MTOR/HIF1A/PRKAA2",3]
["GO:0031060","regulation of histone methylation","3/143","65/18670",0.0135982294999566,0.029932372493651,0.013932532443217,"SIRT1/SETD7/OGT",3]
["GO:0035308","negative regulation of protein dephosphorylation","3/143","65/18670",0.0135982294999566,0.029932372493651,0.013932532443217,"GSK3B/IKBKB/TNF",3]
["GO:0050854","regulation of antigen receptor-mediated signaling pathway","3/143","65/18670",0.0135982294999566,0.029932372493651,0.013932532443217,"PRKCB/BLK/PTPN22",3]
["GO:0050864","regulation of B cell activation","5/143","184/18670",0.0137238507035369,0.0301924715477811,0.014053599976734,"TLR4/TLR9/CASP3/IL2/IL6",5]
["GO:0007369","gastrulation","5/143","185/18670",0.0140205893758716,0.0308285419845345,0.0143496697920524,"FGFR1/MMP9/MMP2/HNF4A/TP53",5]
["GO:0030968","endoplasmic reticulum unfolded protein response","4/143","121/18670",0.01406008406401,0.0308985995065757,0.0143822792585736,"PIK3R1/PTPN1/EIF2AK3/NFE2L2",4]
["GO:0099072","regulation of postsynaptic membrane neurotransmitter receptor levels","3/143","66/18670",0.014167378147815,0.0310669267293365,0.0144606300305576,"MAPK10/HRAS/PRKCZ",3]
["GO:1902108","regulation of mitochondrial membrane permeability involved in apoptotic process","3/143","66/18670",0.014167378147815,0.0310669267293365,0.0144606300305576,"GSK3B/MAPK8/TP53",3]
["GO:1905207","regulation of cardiocyte differentiation","3/143","66/18670",0.014167378147815,0.0310669267293365,0.0144606300305576,"MTOR/PPARA/PARP2",3]
["GO:1905710","positive regulation of membrane permeability","3/143","66/18670",0.014167378147815,0.0310669267293365,0.0144606300305576,"GSK3B/MAPK8/TP53",3]
["GO:0030308","negative regulation of cell growth","5/143","186/18670",0.0143216215455851,0.0313377126537831,0.0145866719498314,"PPARG/PPARA/HNF4A/SIRT1/TP53",5]
["GO:0002407","dendritic cell chemotaxis","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"PIK3CG/CCR5",2]
["GO:0002861","regulation of inflammatory response to antigenic stimulus","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"CNR1/TNF",2]
["GO:0014850","response to muscle activity","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"HIF1A/PRKAA2",2]
["GO:0021511","spinal cord patterning","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"SHH/GLI2",2]
["GO:0021904","dorsal/ventral neural tube patterning","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"SHH/GLI2",2]
["GO:0033081","regulation of T cell differentiation in thymus","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"SHH/GLI2",2]
["GO:0034505","tooth mineralization","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"PPARA/FOXO1",2]
["GO:0046639","negative regulation of alpha-beta T cell differentiation","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"IL2/SHH",2]
["GO:0060148","positive regulation of posttranscriptional gene silencing","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"STAT3/TP53",2]
["GO:0060343","trabecula formation","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"MMP2/RBP4",2]
["GO:0071677","positive regulation of mononuclear cell migration","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"TNF/SERPINE1",2]
["GO:1900078","positive regulation of cellular response to insulin stimulus","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"SIRT1/PRKCZ",2]
["GO:1903649","regulation of cytoplasmic transport","2/143","24/18670",0.0143992454387442,0.0313377126537831,0.0145866719498314,"MAPK1/MAPK3",2]
["GO:0048662","negative regulation of smooth muscle cell proliferation","3/143","67/18670",0.0147498958538929,0.0320663686447683,0.0149258372878446,"PPARG/IGFBP3/HMOX1",3]
["GO:2000573","positive regulation of DNA biosynthetic process","3/143","67/18670",0.0147498958538929,0.0320663686447683,0.0149258372878446,"MAPK1/MAPK3/FGF2",3]
["GO:0002062","chondrocyte differentiation","4/143","123/18670",0.0148515980243891,0.032252826610905,0.0150126273230497,"MAPK14/FGFR1/EIF2AK3/GLI2",4]
["GO:0051928","positive regulation of calcium ion transport","4/143","123/18670",0.0148515980243891,0.032252826610905,0.0150126273230497,"MCHR1/F2/CASR/ATP2A1",4]
["GO:0051101","regulation of DNA binding","4/143","124/18670",0.0152577064346037,0.0331169949851345,0.0154148692072475,"MAPK8/MMP9/PPARG/HMOX1",4]
["GO:0071230","cellular response to amino acid stimulus","3/143","68/18670",0.015345818459668,0.0332903928857105,0.0154955802125603,"MTOR/MMP2/TNF",3]
["GO:0002068","glandular epithelial cell development","2/143","25/18670",0.0155735845723873,0.0335865052472157,0.0156334107532026,"GSK3B/HNF4A",2]
["GO:0002719","negative regulation of cytokine production involved in immune response","2/143","25/18670",0.0155735845723873,0.0335865052472157,0.0156334107532026,"TNF/HMOX1",2]
["GO:0003071","renal system process involved in regulation of systemic arterial blood pressure","2/143","25/18670",0.0155735845723873,0.0335865052472157,0.0156334107532026,"REN/AGTR1",2]
["GO:0003309","type B pancreatic cell differentiation","2/143","25/18670",0.0155735845723873,0.0335865052472157,0.0156334107532026,"GSK3B/HNF4A",2]
["GO:0031639","plasminogen activation","2/143","25/18670",0.0155735845723873,0.0335865052472157,0.0156334107532026,"PLAT/SERPINE1",2]
["GO:0032104","regulation of response to extracellular stimulus","2/143","25/18670",0.0155735845723873,0.0335865052472157,0.0156334107532026,"MTOR/PPARA",2]
["GO:0032107","regulation of response to nutrient levels","2/143","25/18670",0.0155735845723873,0.0335865052472157,0.0156334107532026,"MTOR/PPARA",2]
["GO:0045672","positive regulation of osteoclast differentiation","2/143","25/18670",0.0155735845723873,0.0335865052472157,0.0156334107532026,"TNF/FOS",2]
["GO:0097186","amelogenesis","2/143","25/18670",0.0155735845723873,0.0335865052472157,0.0156334107532026,"PPARA/FOXO1",2]
["GO:1900101","regulation of endoplasmic reticulum unfolded protein response","2/143","25/18670",0.0155735845723873,0.0335865052472157,0.0156334107532026,"PIK3R1/PTPN1",2]
["GO:1904385","cellular response to angiotensin","2/143","25/18670",0.0155735845723873,0.0335865052472157,0.0156334107532026,"AGTR1/NFE2L2",2]
["GO:0010466","negative regulation of peptidase activity","6/143","262/18670",0.0156392683308552,0.0337102013862098,0.0156909872273028,"PTGS2/MMP9/AKT1/VEGFA/SERPINE1/GAPDH",6]
["GO:0006805","xenobiotic metabolic process","4/143","125/18670",0.0156707644510996,0.0337242182339454,0.0156975116077497,"HNF4A/CYP3A4/AOC3/CYP26B1",4]
["GO:0030326","embryonic limb morphogenesis","4/143","125/18670",0.0156707644510996,0.0337242182339454,0.0156975116077497,"FGFR1/SHH/GLI2/CYP26B1",4]
["GO:0035113","embryonic appendage morphogenesis","4/143","125/18670",0.0156707644510996,0.0337242182339454,0.0156975116077497,"FGFR1/SHH/GLI2/CYP26B1",4]
["GO:0071300","cellular response to retinoic acid","3/143","69/18670",0.01595517846173,0.0342998207185784,0.0159654355851507,"YES1/PPARG/CYP26B1",3]
["GO:2000243","positive regulation of reproductive process","3/143","69/18670",0.01595517846173,0.0342998207185784,0.0159654355851507,"AR/INSR/SHH",3]
["GO:0002377","immunoglobulin production","5/143","193/18670",0.0165511905873808,0.0355255503142861,0.0165359722962794,"TLR9/IL2/TNF/IL6/RBP4",5]
["GO:0002709","regulation of T cell mediated immunity","3/143","70/18670",0.0165780050750213,0.0355255503142861,0.0165359722962794,"IL6/PRKCZ/IL1B",3]
["GO:0033077","T cell differentiation in thymus","3/143","70/18670",0.0165780050750213,0.0355255503142861,0.0165359722962794,"SHH/GLI2/TP53",3]
["GO:0050766","positive regulation of phagocytosis","3/143","70/18670",0.0165780050750213,0.0355255503142861,0.0165359722962794,"PPARG/TNF/IL1B",3]
["GO:0051966","regulation of synaptic transmission, glutamatergic","3/143","70/18670",0.0165780050750213,0.0355255503142861,0.0165359722962794,"PTGS2/CNR1/TNF",3]
["GO:0060395","SMAD protein signal transduction","3/143","70/18670",0.0165780050750213,0.0355255503142861,0.0165359722962794,"LNPEP/FOS/HNF4A",3]
["GO:0006309","apoptotic DNA fragmentation","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"CASP3/IL6",2]
["GO:0010460","positive regulation of heart rate","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"KCNQ1/AVPR1A",2]
["GO:0022011","myelination in peripheral nervous system","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"AKT1/AKT2",2]
["GO:0031954","positive regulation of protein autophosphorylation","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"VEGFA/ACE",2]
["GO:0032292","peripheral nervous system axon ensheathment","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"AKT1/AKT2",2]
["GO:0033561","regulation of water loss via skin","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"ALOX12/CYP26B1",2]
["GO:0034114","regulation of heterotypic cell-cell adhesion","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"TNF/IL1B",2]
["GO:0043567","regulation of insulin-like growth factor receptor signaling pathway","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"AR/IGFBP3",2]
["GO:1900739","regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"MAPK8/TP53",2]
["GO:1900740","positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"MAPK8/TP53",2]
["GO:1903203","regulation of oxidative stress-induced neuron death","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"TLR4/HIF1A",2]
["GO:1904353","regulation of telomere capping","2/143","26/18670",0.0167876037089371,0.0357476169457009,0.0166393369910559,"MAPK1/MAPK3",2]
["GO:0003206","cardiac chamber morphogenesis","4/143","129/18670",0.0173931888086326,0.036998228217207,0.0172214553018516,"NOS3/HIF1A/TP53/RBP4",4]
["GO:0050853","B cell receptor signaling pathway","4/143","129/18670",0.0173931888086326,0.036998228217207,0.0172214553018516,"MAPK1/PRKCB/BLK/PTPN22",4]
["GO:0006644","phospholipid metabolic process","8/143","430/18670",0.0178381381680461,0.0379203542060454,0.0176506745446279,"FLT1/PIK3CA/PIK3CG/PIK3R1/PON1/FGF2/AGPAT2/CETP",8]
["GO:0006305","DNA alkylation","3/143","72/18670",0.0178641589602096,0.0379203542060454,0.0176506745446279,"PIK3CA/FOS/PRMT7",3]
["GO:0006306","DNA methylation","3/143","72/18670",0.0178641589602096,0.0379203542060454,0.0176506745446279,"PIK3CA/FOS/PRMT7",3]
["GO:0051881","regulation of mitochondrial membrane potential","3/143","72/18670",0.0178641589602096,0.0379203542060454,0.0176506745446279,"AKT1/ALOX12/AKT2",3]
["GO:0002221","pattern recognition receptor signaling pathway","5/143","197/18670",0.0179235050349234,0.0380263880405503,0.0177000297983631,"TLR4/TLR9/IKBKB/ESR1/PTPN22",5]
["GO:0002021","response to dietary excess","2/143","27/18670",0.0180406350287678,0.0381150785994009,0.0177413123291366,"ADRB2/MC4R",2]
["GO:0006706","steroid catabolic process","2/143","27/18670",0.0180406350287678,0.0381150785994009,0.0177413123291366,"CYP19A1/CYP3A4",2]
["GO:0035883","enteroendocrine cell differentiation","2/143","27/18670",0.0180406350287678,0.0381150785994009,0.0177413123291366,"GSK3B/HNF4A",2]
["GO:0036336","dendritic cell migration","2/143","27/18670",0.0180406350287678,0.0381150785994009,0.0177413123291366,"PIK3CG/CCR5",2]
["GO:0036475","neuron death in response to oxidative stress","2/143","27/18670",0.0180406350287678,0.0381150785994009,0.0177413123291366,"TLR4/HIF1A",2]
["GO:0045671","negative regulation of osteoclast differentiation","2/143","27/18670",0.0180406350287678,0.0381150785994009,0.0177413123291366,"TLR4/PIK3R1",2]
["GO:1905563","negative regulation of vascular endothelial cell proliferation","2/143","27/18670",0.0180406350287678,0.0381150785994009,0.0177413123291366,"FLT1/PPARG",2]
["GO:2000144","positive regulation of DNA-templated transcription, initiation","2/143","27/18670",0.0180406350287678,0.0381150785994009,0.0177413123291366,"ESR1/TP53",2]
["GO:0032945","negative regulation of mononuclear cell proliferation","3/143","73/18670",0.018527528810848,0.0391029388041256,0.0182011286819703,"CASP3/IL2/SHH",3]
["GO:0050672","negative regulation of lymphocyte proliferation","3/143","73/18670",0.018527528810848,0.0391029388041256,0.0182011286819703,"CASP3/IL2/SHH",3]
["GO:0042177","negative regulation of protein catabolic process","4/143","132/18670",0.0187596308194355,0.0395309659328864,0.0184003611971777,"NOS2/HMGCR/SHH/OGT",4]
["GO:0042552","myelination","4/143","132/18670",0.0187596308194355,0.0395309659328864,0.0184003611971777,"MTOR/AKT1/AKT2/EIF2AK3",4]
["GO:0055007","cardiac muscle cell differentiation","4/143","132/18670",0.0187596308194355,0.0395309659328864,0.0184003611971777,"MTOR/PPARA/VEGFA/PARP2",4]
["GO:0032507","maintenance of protein location in cell","3/143","74/18670",0.0192044505507062,0.0404214932037114,0.0188148722786154,"AKT1/HK2/HK1",3]
["GO:0051145","smooth muscle cell differentiation","3/143","74/18670",0.0192044505507062,0.0404214932037114,0.0188148722786154,"SHH/VEGFA/SIRT1",3]
["GO:0009065","glutamine family amino acid catabolic process","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"NOS2/NOS3",2]
["GO:0032647","regulation of interferon-alpha production","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"TLR4/TLR9",2]
["GO:0033598","mammary gland epithelial cell proliferation","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"MAPK1/ESR1",2]
["GO:0034368","protein-lipid complex remodeling","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"AGTR1/CETP",2]
["GO:0034369","plasma lipoprotein particle remodeling","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"AGTR1/CETP",2]
["GO:0036296","response to increased oxygen levels","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"PPARG/FOXO1",2]
["GO:0048520","positive regulation of behavior","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"MTOR/MTNR1B",2]
["GO:0051123","RNA polymerase II preinitiation complex assembly","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"ESR1/TP53",2]
["GO:0060260","regulation of transcription initiation from RNA polymerase II promoter","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"ESR1/TP53",2]
["GO:0090344","negative regulation of cell aging","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"NAMPT/SIRT1",2]
["GO:1902003","regulation of amyloid-beta formation","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"CASP3/TNF",2]
["GO:1904994","regulation of leukocyte adhesion to vascular endothelial cell","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"TNF/ICAM1",2]
["GO:2000463","positive regulation of excitatory postsynaptic potential","2/143","28/18670",0.0193320184887315,0.0404214932037114,0.0188148722786154,"PRKCZ/ADRB2",2]
["GO:0007272","ensheathment of neurons","4/143","134/18670",0.0197065896628659,0.0411409360264472,0.019149749190592,"MTOR/AKT1/AKT2/EIF2AK3",4]
["GO:0008366","axon ensheathment","4/143","134/18670",0.0197065896628659,0.0411409360264472,0.019149749190592,"MTOR/AKT1/AKT2/EIF2AK3",4]
["GO:0048565","digestive tract development","4/143","134/18670",0.0197065896628659,0.0411409360264472,0.019149749190592,"SHH/TNF/HIF1A/GLI2",4]
["GO:0030010","establishment of cell polarity","4/143","135/18670",0.0201909545334328,0.042087015422933,0.0195901179548185,"GSK3B/SHH/PRKCZ/CYP26B1",4]
["GO:1903825","organic acid transmembrane transport","4/143","135/18670",0.0201909545334328,0.042087015422933,0.0195901179548185,"AKT1/AKT2/PRKAA2/ACACB",4]
["GO:1905039","carboxylic acid transmembrane transport","4/143","135/18670",0.0201909545334328,0.042087015422933,0.0195901179548185,"AKT1/AKT2/PRKAA2/ACACB",4]
["GO:0035637","multicellular organismal signaling","5/143","204/18670",0.0205023591389725,0.0427141275319406,0.019882017963952,"MTNR1B/KCNQ1/AVPR1A/KCNJ11/ATP2A1",5]
["GO:0000422","autophagy of mitochondrion","3/143","76/18670",0.0205990016794032,0.0427369135707867,0.0198926241137165,"HK2/HIF1A/TP53",3]
["GO:0001937","negative regulation of endothelial cell proliferation","3/143","76/18670",0.0205990016794032,0.0427369135707867,0.0198926241137165,"FLT1/PPARG/TNF",3]
["GO:0061726","mitochondrion disassembly","3/143","76/18670",0.0205990016794032,0.0427369135707867,0.0198926241137165,"HK2/HIF1A/TP53",3]
["GO:0014044","Schwann cell development","2/143","29/18670",0.0206611017435844,0.0427369135707867,0.0198926241137165,"AKT1/AKT2",2]
["GO:0034367","protein-containing complex remodeling","2/143","29/18670",0.0206611017435844,0.0427369135707867,0.0198926241137165,"AGTR1/CETP",2]
["GO:0035666","TRIF-dependent toll-like receptor signaling pathway","2/143","29/18670",0.0206611017435844,0.0427369135707867,0.0198926241137165,"TLR4/IKBKB",2]
["GO:0045822","negative regulation of heart contraction","2/143","29/18670",0.0206611017435844,0.0427369135707867,0.0198926241137165,"PIK3CG/IL2",2]
["GO:0060441","epithelial tube branching involved in lung morphogenesis","2/143","29/18670",0.0206611017435844,0.0427369135707867,0.0198926241137165,"SHH/TNF",2]
["GO:0070102","interleukin-6-mediated signaling pathway","2/143","29/18670",0.0206611017435844,0.0427369135707867,0.0198926241137165,"STAT3/IL6",2]
["GO:0070229","negative regulation of lymphocyte apoptotic process","2/143","29/18670",0.0206611017435844,0.0427369135707867,0.0198926241137165,"IL2/HIF1A",2]
["GO:0070528","protein kinase C signaling","2/143","29/18670",0.0206611017435844,0.0427369135707867,0.0198926241137165,"VEGFA/PRKCZ",2]
["GO:0072606","interleukin-8 secretion","2/143","29/18670",0.0206611017435844,0.0427369135707867,0.0198926241137165,"NOS2/PTPN22",2]
["GO:1900027","regulation of ruffle assembly","2/143","29/18670",0.0206611017435844,0.0427369135707867,0.0198926241137165,"HRAS/ICAM1",2]
["GO:2000727","positive regulation of cardiac muscle cell differentiation","2/143","29/18670",0.0206611017435844,0.0427369135707867,0.0198926241137165,"MTOR/PARP2",2]
["GO:0006936","muscle contraction","7/143","360/18670",0.0210415270379495,0.0435015839885698,0.0202485529799095,"PTGS2/PIK3CA/PIK3CG/MTOR/KCNQ1/ADRB2/ATP2A1",7]
["GO:0010976","positive regulation of neuron projection development","6/143","281/18670",0.0212728016477948,0.0439348474848333,0.020450222851532,"FGFR1/MTOR/CNR1/IL2/VEGFA/NFE2L2",6]
["GO:0030100","regulation of endocytosis","6/143","281/18670",0.0212728016477948,0.0439348474848333,0.020450222851532,"PTPN1/PPARG/TNF/VEGFA/SERPINE1/IL1B",6]
["GO:0031397","negative regulation of protein ubiquitination","3/143","77/18670",0.0213166498161744,0.0439805292843393,0.0204714862229476,"MTOR/AKT1/OGT",3]
["GO:0032481","positive regulation of type I interferon production","3/143","77/18670",0.0213166498161744,0.0439805292843393,0.0204714862229476,"TLR4/TLR9/PTPN22",3]
["GO:0001654","eye development","7/143","362/18670",0.021610607646026,0.0445643096032162,0.0207432167125434,"MTNR1B/STAT3/SHH/IMPDH2/VEGFA/HIF1A/RBP4",7]
["GO:0001782","B cell homeostasis","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"CASP3/HIF1A",2]
["GO:0001844","protein insertion into mitochondrial membrane involved in apoptotic signaling pathway","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"MAPK8/TP53",2]
["GO:0002828","regulation of type 2 immune response","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"IL6/PRKCZ",2]
["GO:0032607","interferon-alpha production","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"TLR4/TLR9",2]
["GO:0032728","positive regulation of interferon-beta production","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"TLR4/TLR9",2]
["GO:0035066","positive regulation of histone acetylation","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"MAPK3/IL1B",2]
["GO:0043171","peptide catabolic process","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"LNPEP/ACE",2]
["GO:0045948","positive regulation of translational initiation","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"MTOR/TNF",2]
["GO:0048147","negative regulation of fibroblast proliferation","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"PPARG/TP53",2]
["GO:0048384","retinoic acid receptor signaling pathway","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"RXRG/CYP26B1",2]
["GO:0070168","negative regulation of biomineral tissue development","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"NOS3/HIF1A",2]
["GO:0071480","cellular response to gamma radiation","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"HRAS/TP53",2]
["GO:0071549","cellular response to dexamethasone stimulus","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"FOXO1/ICAM1",2]
["GO:0090200","positive regulation of release of cytochrome c from mitochondria","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"MMP9/TP53",2]
["GO:0090314","positive regulation of protein targeting to membrane","2/143","30/18670",0.0220272400681465,0.045030195966555,0.020960071453124,"HRAS/AKT2",2]
["GO:0032413","negative regulation of ion transmembrane transporter activity","3/143","78/18670",0.022047887452004,0.045030195966555,0.020960071453124,"MMP9/TLR9/MTNR1B",3]
["GO:0033143","regulation of intracellular steroid hormone receptor signaling pathway","3/143","78/18670",0.022047887452004,0.045030195966555,0.020960071453124,"AR/ESR1/SIRT1",3]
["GO:0070664","negative regulation of leukocyte proliferation","3/143","78/18670",0.022047887452004,0.045030195966555,0.020960071453124,"CASP3/IL2/SHH",3]
["GO:2000300","regulation of synaptic vesicle exocytosis","3/143","78/18670",0.022047887452004,0.045030195966555,0.020960071453124,"GSK3B/PRKCB/CNR1",3]
["GO:0007189","adenylate cyclase-activating G protein-coupled receptor signaling pathway","4/143","139/18670",0.022201605448075,0.0452984369222821,0.0210849287733735,"ADRB3/GCGR/ADRB2/MC4R",4]
["GO:0016571","histone methylation","4/143","139/18670",0.022201605448075,0.0452984369222821,0.0210849287733735,"SIRT1/SETD7/PRMT7/OGT",4]
["GO:0031647","regulation of protein stability","6/143","284/18670",0.0222730733488943,0.0454213606631355,0.0211421457216072,"MAPK1/PIK3R1/CASP3/SIRT1/GAPDH/TP53",6]
["GO:0035303","regulation of dephosphorylation","5/143","209/18670",0.022485969965577,0.0458093640768273,0.0213227485171419,"GSK3B/MTOR/IKBKB/TNF/IGFBP3",5]
["GO:0051701","interaction with host","5/143","209/18670",0.022485969965577,0.0458093640768273,0.0213227485171419,"INSR/DPP4/GAPDH/ICAM1/CCR5",5]
["GO:0034620","cellular response to unfolded protein","4/143","140/18670",0.0227226909653744,0.0462450744232457,0.0215255573168322,"PIK3R1/PTPN1/EIF2AK3/NFE2L2",4]
["GO:0060078","regulation of postsynaptic membrane potential","4/143","140/18670",0.0227226909653744,0.0462450744232457,0.0215255573168322,"GSK3B/AKT1/PRKCZ/ADRB2",4]
["GO:0150063","visual system development","7/143","366/18670",0.022780760459162,0.0463399589641646,0.0215697229420259,"MTNR1B/STAT3/SHH/IMPDH2/VEGFA/HIF1A/RBP4",7]
["GO:0006446","regulation of translational initiation","3/143","79/18670",0.0227927169731857,0.0463409936250405,0.021570204542548,"MTOR/TNF/EIF2AK3",3]
["GO:0045088","regulation of innate immune response","8/143","452/18670",0.0232299805560068,0.0472063058688331,0.0219729788603108,"TLR4/TLR9/IKBKB/ESR1/PTPN1/PPARG/HRAS/PTPN22",8]
["GO:0003401","axis elongation","2/143","31/18670",0.02342979628019,0.0473745331379666,0.0220512831071771,"ESR1/SHH",2]
["GO:0009954","proximal/distal pattern formation","2/143","31/18670",0.02342979628019,0.0473745331379666,0.0220512831071771,"GLI2/CYP26B1",2]
["GO:0010165","response to X-ray","2/143","31/18670",0.02342979628019,0.0473745331379666,0.0220512831071771,"CASP3/TP53",2]
["GO:0010762","regulation of fibroblast migration","2/143","31/18670",0.02342979628019,0.0473745331379666,0.0220512831071771,"AKT1/FGF2",2]
["GO:0030431","sleep","2/143","31/18670",0.02342979628019,0.0473745331379666,0.0220512831071771,"MTNR1B/FOS",2]
["GO:0045742","positive regulation of epidermal growth factor receptor signaling pathway","2/143","31/18670",0.02342979628019,0.0473745331379666,0.0220512831071771,"MMP9/AKT1",2]
["GO:0048710","regulation of astrocyte differentiation","2/143","31/18670",0.02342979628019,0.0473745331379666,0.0220512831071771,"F2/IL6",2]
["GO:0050849","negative regulation of calcium-mediated signaling","2/143","31/18670",0.02342979628019,0.0473745331379666,0.0220512831071771,"GSK3B/MTOR",2]
["GO:0071880","adenylate cyclase-activating adrenergic receptor signaling pathway","2/143","31/18670",0.02342979628019,0.0473745331379666,0.0220512831071771,"ADRB3/ADRB2",2]
["GO:1902253","regulation of intrinsic apoptotic signaling pathway by p53 class mediator","2/143","31/18670",0.02342979628019,0.0473745331379666,0.0220512831071771,"SIRT1/TP53",2]
["GO:0043462","regulation of ATPase activity","3/143","80/18670",0.0235511380707637,0.0475723587377503,0.0221433644010227,"TLR9/CASR/ATP2A1",3]
["GO:0070509","calcium ion import","3/143","80/18670",0.0235511380707637,0.0475723587377503,0.0221433644010227,"GCK/CASR/ATP2A1",3]
["GO:0050871","positive regulation of B cell activation","4/143","142/18670",0.0237871326732919,0.0480011530715283,0.0223429540248688,"TLR4/TLR9/IL2/IL6",4]
["GO:0072006","nephron development","4/143","142/18670",0.0237871326732919,0.0480011530715283,0.0223429540248688,"SHH/VEGFA/FGF2/PGF",4]
["GO:0045666","positive regulation of neuron differentiation","7/143","371/18670",0.0243043366342675,0.0489959933742604,0.022806019383172,"FGFR1/MTOR/CNR1/IL2/VEGFA/GLI2/NFE2L2",7]
["GO:0048880","sensory system development","7/143","371/18670",0.0243043366342675,0.0489959933742604,0.022806019383172,"MTNR1B/STAT3/SHH/IMPDH2/VEGFA/HIF1A/RBP4",7]
["GO:0032436","positive regulation of proteasomal ubiquitin-dependent protein catabolic process","3/143","81/18670",0.0243231477947848,0.0489999972616556,0.0228078830607353,"GSK3B/AKT1/NFE2L2",3]
["GO:0044344","cellular response to fibroblast growth factor stimulus","4/143","143/18670",0.0243305322371363,0.0489999972616556,0.0228078830607353,"MAPK1/FGFR1/MAPK3/FGF2",4]
["GO:1903050","regulation of proteolysis involved in cellular protein catabolic process","5/143","214/18670",0.0245903515603668,0.0494986290981426,0.023039979739358,"GSK3B/AKT1/SHH/OGT/NFE2L2",5]
["GO:0001569","branching involved in blood vessel morphogenesis","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"SHH/VEGFA",2]
["GO:0006356","regulation of transcription by RNA polymerase I","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"MTOR/EIF2AK3",2]
["GO:0006739","NADP metabolic process","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"GCK/TKT",2]
["GO:0008210","estrogen metabolic process","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"CYP19A1/CYP3A4",2]
["GO:0038128","ERBB2 signaling pathway","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"PIK3CA/PIK3R1",2]
["GO:0042573","retinoic acid metabolic process","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"CYP3A4/CYP26B1",2]
["GO:0043552","positive regulation of phosphatidylinositol 3-kinase activity","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"FLT1/FGF2",2]
["GO:0051385","response to mineralocorticoid","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"AVPR1A/FOS",2]
["GO:0055022","negative regulation of cardiac muscle tissue growth","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"PPARA/RBP4",2]
["GO:0060674","placenta blood vessel development","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"MAPK1/AKT1",2]
["GO:0061117","negative regulation of heart growth","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"PPARA/RBP4",2]
["GO:1900745","positive regulation of p38MAPK cascade","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"VEGFA/IL1B",2]
["GO:1901661","quinone metabolic process","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"HMGCR/AKR1B1",2]
["GO:2000778","positive regulation of interleukin-6 secretion","2/143","32/18670",0.0248681406640479,0.049711720201514,0.0231391666217782,"TNF/IL1B",2]
["GO:0010810","regulation of cell-substrate adhesion","5/143","215/18670",0.0250259217951153,0.0499777658740141,0.02326300211007,"GSK3B/PIK3R1/VEGFA/SERPINE1/PRKCZ",5]
["GO:0019935","cyclic-nucleotide-mediated signaling","5/143","215/18670",0.0250259217951153,0.0499777658740141,0.02326300211007,"ADRB3/MTNR1B/GCGR/ADRB2/MC4R",5]

{"sheet":"Sheet3","index":2,"n_rows":18,"n_cols":9,"rows_kept":18,"merged":[[0,0,0,8]],"flags":["formulas_cached_only"]}
["Gene Ontology (GO) results in cell components"]
["ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID","Count"]
["GO:0045121","membrane raft","18/144","315/19717",{"v":1.68341051693446e-11,"d":"1.68E-11"},{"v":2.3596602255925e-09,"d":"2.36E-09"},{"v":2.00762543926548e-09,"d":"2.01E-09"},"PTGS2/MAPK1/INSR/MAPK3/KCNQ1/NOS3/CNR1/IKBKB/CASP3/SLC2A1/HK1/SHH/TNF/DPP4/HMOX1/PRKCZ/LIPE/ICAM1",18]
["GO:0098857","membrane microdomain","18/144","316/19717",{"v":1.77418062074624e-11,"d":"1.77E-11"},{"v":2.3596602255925e-09,"d":"2.36E-09"},{"v":2.00762543926548e-09,"d":"2.01E-09"},"PTGS2/MAPK1/INSR/MAPK3/KCNQ1/NOS3/CNR1/IKBKB/CASP3/SLC2A1/HK1/SHH/TNF/DPP4/HMOX1/PRKCZ/LIPE/ICAM1",18]
["GO:0098589","membrane region","18/144","328/19717",{"v":3.28383411206994e-11,"d":"3.28E-11"},{"v":2.91166624603535e-09,"d":"2.91E-09"},{"v":2.47727836524574e-09,"d":"2.48E-09"},"PTGS2/MAPK1/INSR/MAPK3/KCNQ1/NOS3/CNR1/IKBKB/CASP3/SLC2A1/HK1/SHH/TNF/DPP4/HMOX1/PRKCZ/LIPE/ICAM1",18]
["GO:0005901","caveola","8/144","80/19717",{"v":1.238495539518e-07,"d":"1.24E-07"},{"v":8.23599533779471e-06,"d":"8.24E-06"},{"v":7.00727739464132e-06,"d":"7.01E-06"},"PTGS2/MAPK1/INSR/MAPK3/NOS3/SLC2A1/HMOX1/LIPE",8]
["GO:0045177","apical part of cell","14/144","384/19717",{"v":8.87628410205843e-07,"d":"8.88E-07"},{"v":4.72218314229508e-05,"d":"4.72E-05"},{"v":4.01768648830013e-05,"d":"4.02E-05"},"TLR9/REN/SLC2A1/MGAM/PLAT/SLC22A12/CFTR/SLC5A1/DPP4/TRPM6/PRKCZ/ADRB2/CASR/SI",14]
["GO:0044853","plasma membrane raft","8/144","109/19717",{"v":1.35866174773771e-06,"d":"1.36E-06"},{"v":6.0234004149705e-05,"d":"6.02E-05"},{"v":5.12477676778258e-05,"d":"5.12E-05"},"PTGS2/MAPK1/INSR/MAPK3/NOS3/SLC2A1/HMOX1/LIPE",8]
["GO:0016324","apical plasma membrane","12/144","318/19717",{"v":3.90468932735658e-06,"d":"3.90E-06"},{"v":0.00014837819443955,"d":"1.48E-04"},{"v":0.000126241835395739,"d":"1.26E-04"},"TLR9/SLC2A1/MGAM/SLC22A12/CFTR/SLC5A1/DPP4/TRPM6/PRKCZ/ADRB2/CASR/SI",12]
["GO:0090575","RNA polymerase II transcription factor complex","8/144","163/19717",{"v":2.66713012036923e-05,"d":"2.67E-05"},{"v":0.000886820765022769,"d":"8.87E-04"},{"v":0.000754517073525506,"d":"7.55E-04"},"STAT3/VDR/PPARG/PPARA/FOS/HIF1A/RXRG/TP53",8]
["GO:0044798","nuclear transcription factor complex","8/144","201/19717",{"v":0.000116893423958549,"d":"1.17E-04"},{"v":0.00345485008588601,"d":"3.45E-03"},{"v":0.00293942528082902,"d":"2.94E-03"},"STAT3/VDR/PPARG/PPARA/FOS/HIF1A/RXRG/TP53",8]
["GO:0098978","glutamatergic synapse","10/144","349/19717",{"v":0.000250240752511098,"d":"2.50E-04"},{"v":0.00619095667720788,"d":"6.19E-03"},{"v":0.00526733551879579,"d":"5.27E-03"},"GSK3B/MAPK14/MAPK10/MTOR/STAT3/YES1/CNR1/PLAT/HRAS/PRKCZ",10]
["GO:0005769","early endosome","10/144","350/19717",{"v":0.000256017005448446,"d":"2.56E-04"},{"v":0.00619095667720788,"d":"6.19E-03"},{"v":0.00526733551879579,"d":"5.27E-03"},"TLR4/MAPK1/MAPK3/KCNQ1/PTPN1/LNPEP/CFTR/AKT2/AOC3/ADRB2",10]
["GO:0061695","transferase complex, transferring phosphorus-containing groups","8/144","259/19717",{"v":0.000644117509173543,"d":"6.44E-04"},{"v":0.0140399076984212,"d":"1.40E-02"},{"v":0.0119453112590446,"d":"1.19E-02"},"PIK3CA/PIK3CG/IGF1R/INSR/PIK3R1/IKBKB/TP53/PRKAA2",8]
["GO:0016607","nuclear speck","10/144","397/19717",{"v":0.000686160902554421,"d":"6.86E-04"},{"v":0.0140399076984212,"d":"1.40E-02"},{"v":0.0119453112590446,"d":"1.19E-02"},"AR/MAPK14/NAMPT/CLK2/SGK1/HIF1A/GLI2/PRKAA2/FTO/TKT",10]
["GO:0005942","phosphatidylinositol 3-kinase complex","3/144","27/19717",{"v":0.000981302536857882,"d":"9.81E-04"},{"v":0.0186447482002998,"d":"1.86E-02"},{"v":0.0158631613101086,"d":"1.59E-02"},"PIK3CA/PIK3CG/PIK3R1",3]
["GO:0098562","cytoplasmic side of membrane","6/144","178/19717",{"v":0.00198494110001205,"d":"1.98E-03"},{"v":0.0351996221735471,"d":"3.52E-02"},{"v":0.0299482341405327,"d":"2.99E-02"},"BLK/YES1/IKBKB/PTPN1/ACP1/PTPN22",6]
["GO:0009897","external side of plasma membrane","9/144","393/19717",{"v":0.00242864472807644,"d":"2.43E-03"},0.0403762186042708,0.0343525405616075,"TLR4/SELP/F2/INSR/TNF/ACE/ICAM1/CCR5/GSR",9]

{"sheet":"Sheet4","index":3,"n_rows":157,"n_cols":9,"rows_kept":157,"merged":[[0,0,0,8]],"flags":["formulas_cached_only"]}
["Results of KEGG pathways"]
["ID","Description","GeneRatio","BgRatio","pvalue","p.adjust","qvalue","geneID","Count"]
["hsa04933","AGE-RAGE signaling pathway in diabetic complications","24/130","100/8081",{"v":2.93678176144261e-22,"d":"2.94E-22"},{"v":7.5475291269075e-20,"d":"7.55E-20"},{"v":2.9058682692169e-20,"d":"2.91E-20"},"MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/PRKCB/MAPK3/STAT3/AKT1/NOS3/PIK3R1/MMP2/CASP3/TNF/HRAS/VEGFA/AKT2/SERPINE1/IL6/PRKCZ/FOXO1/AGTR1/ICAM1/IL1B",24]
["hsa04931","Insulin resistance","24/130","108/8081",{"v":2.14041960248088e-21,"d":"2.14E-21"},{"v":2.32141234810898e-19,"d":"2.32E-19"},{"v":8.93765147336652e-20,"d":"8.94E-20"},"GSK3B/MAPK8/MAPK10/PIK3CA/PRKCB/MTOR/INSR/STAT3/AKT1/NOS3/PIK3R1/IKBKB/PTPN1/SLC2A1/PPARA/TNF/AKT2/IL6/PRKCZ/FOXO1/OGT/PRKAA2/ACACB/GYS1",24]
["hsa04066","HIF-1 signaling pathway","24/130","109/8081",{"v":2.70981986160581e-21,"d":"2.71E-21"},{"v":2.32141234810898e-19,"d":"2.32E-19"},{"v":8.93765147336652e-20,"d":"8.94E-20"},"TLR4/NOS2/MAPK1/FLT1/PIK3CA/IGF1R/PRKCB/MTOR/INSR/MAPK3/STAT3/AKT1/NOS3/PIK3R1/SLC2A1/HK2/HK1/VEGFA/AKT2/SERPINE1/GAPDH/HMOX1/IL6/HIF1A",24]
["hsa04910","Insulin signaling pathway","24/130","137/8081",{"v":8.29273778514723e-19,"d":"8.29E-19"},{"v":5.3280840269571e-17,"d":"5.33E-17"},{"v":2.05136145211537e-17,"d":"2.05E-17"},"BRAF/GSK3B/MAPK1/MAPK8/MAPK10/PIK3CA/GCK/MTOR/INSR/MAPK3/AKT1/PIK3R1/IKBKB/PTPN1/HK2/HK1/HRAS/AKT2/PRKCZ/FOXO1/LIPE/PRKAA2/ACACB/GYS1",24]
["hsa05142","Chagas disease","20/130","102/8081",{"v":8.37426447677614e-17,"d":"8.37E-17"},{"v":4.30437194106293e-15,"d":"4.30E-15"},{"v":1.6572228648778e-15,"d":"1.66E-15"},"TLR4/NOS2/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/TLR9/MAPK3/AKT1/PIK3R1/IKBKB/IL2/TNF/AKT2/FOS/SERPINE1/ACE/IL6/IL1B",20]
["hsa04930","Type II diabetes mellitus","15/130","46/8081",{"v":1.84473707772612e-16,"d":"1.84E-16"},{"v":7.90162381626024e-15,"d":"7.90E-15"},{"v":3.04219798782905e-15,"d":"3.04E-15"},"MAPK1/MAPK8/MAPK10/PIK3CA/GCK/MTOR/INSR/MAPK3/PIK3R1/IKBKB/HK2/HK1/TNF/KCNJ11/PRKCZ",15]
["hsa05418","Fluid shear stress and atherosclerosis","22/130","139/8081",{"v":2.57681819807026e-16,"d":"2.58E-16"},{"v":8.46862942277474e-15,"d":"8.47E-15"},{"v":3.26050037166015e-15,"d":"3.26E-15"},"MAPK14/MAPK8/MAPK10/MMP9/PIK3CA/AKT1/NOS3/PIK3R1/IKBKB/MMP2/PLAT/TNF/VEGFA/AKT2/FOS/HMOX1/PRKCZ/TP53/ICAM1/PRKAA2/NFE2L2/IL1B",22]
["hsa05167","Kaposi sarcoma-associated herpesvirus infection","25/130","193/8081",{"v":2.6361492366614e-16,"d":"2.64E-16"},{"v":8.46862942277474e-15,"d":"8.47E-15"},{"v":3.26050037166015e-15,"d":"3.26E-15"},"GSK3B/MAPK14/PTGS2/MAPK1/MAPK8/MAPK10/PIK3CA/PIK3CG/MTOR/MAPK3/STAT3/AKT1/PIK3R1/IKBKB/CASP3/HRAS/VEGFA/FGF2/AKT2/FOS/IL6/HIF1A/TP53/ICAM1/CCR5",25]
["hsa04068","FoxO signaling pathway","21/130","131/8081",{"v":1.0013952236124e-15,"d":"1.00E-15"},{"v":2.8595396940932e-14,"d":"2.86E-14"},{"v":1.10094913473177e-14,"d":"1.10E-14"},"BRAF/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/IGF1R/INSR/MAPK3/STAT3/AKT1/PIK3R1/IKBKB/SGK1/HRAS/AKT2/SIRT1/SETD7/IL6/FOXO1/PRKAA2",21]
["hsa05205","Proteoglycans in cancer","25/130","205/8081",{"v":1.1274599264468e-15,"d":"1.13E-15"},{"v":2.89757201096827e-14,"d":"2.90E-14"},{"v":1.11559192722104e-14,"d":"1.12E-14"},"BRAF/TLR4/MAPK14/MAPK1/FGFR1/MMP9/PIK3CA/IGF1R/PRKCB/MTOR/MAPK3/STAT3/AKT1/PIK3R1/ESR1/MMP2/CASP3/SHH/TNF/HRAS/VEGFA/FGF2/AKT2/HIF1A/TP53",25]
["hsa05215","Prostate cancer","18/130","97/8081",{"v":9.08540546321542e-15,"d":"9.09E-15"},{"v":2.1226810945876e-13,"d":"2.12E-13"},{"v":8.17251783294018e-14,"d":"8.17E-14"},"BRAF/AR/GSK3B/MAPK1/FGFR1/MMP9/PIK3CA/IGF1R/MTOR/MAPK3/AKT1/PIK3R1/IKBKB/PLAT/HRAS/AKT2/FOXO1/TP53",18]
["hsa01522","Endocrine resistance","18/130","98/8081",{"v":1.09822478204023e-14,"d":"1.10E-14"},{"v":2.35203140820283e-13,"d":"2.35E-13"},{"v":9.05553767647209e-14,"d":"9.06E-14"},"BRAF/MAPK14/MAPK1/MAPK8/MAPK10/MMP9/PIK3CA/IGF1R/MTOR/MAPK3/AKT1/PIK3R1/ESR1/MMP2/HRAS/AKT2/FOS/TP53",18]
["hsa01521","EGFR tyrosine kinase inhibitor resistance","16/130","79/8081",{"v":7.2246775137068e-14,"d":"7.22E-14"},{"v":1.42826317001742e-12,"d":"1.43E-12"},{"v":5.49894482824647e-13,"d":"5.50E-13"},"BRAF/GSK3B/MAPK1/PIK3CA/IGF1R/PRKCB/MTOR/MAPK3/STAT3/AKT1/PIK3R1/HRAS/VEGFA/FGF2/AKT2/IL6",16]
["hsa05161","Hepatitis B","21/130","162/8081",{"v":8.09314006004246e-14,"d":"8.09E-14"},{"v":1.48566928245065e-12,"d":"1.49E-12"},{"v":5.71996365145858e-13,"d":"5.72E-13"},"BRAF/TLR4/MAPK14/MAPK1/MAPK8/MAPK10/MMP9/PIK3CA/PRKCB/MAPK3/STAT3/AKT1/PIK3R1/IKBKB/CASP3/TNF/HRAS/AKT2/FOS/IL6/TP53",21]
["hsa04668","TNF signaling pathway","18/130","112/8081",{"v":1.25614101377077e-13,"d":"1.26E-13"},{"v":2.15218827026059e-12,"d":"2.15E-12"},{"v":8.28612317855807e-13,"d":"8.29E-13"},"MAPK14/PTGS2/MAPK1/MAPK8/MAPK10/MMP9/PIK3CA/MAPK3/AKT1/PIK3R1/IKBKB/CASP3/TNF/AKT2/FOS/IL6/ICAM1/IL1B",18]
["hsa04917","Prolactin signaling pathway","15/130","70/8081",{"v":1.88141162848668e-13,"d":"1.88E-13"},{"v":2.84425169718281e-12,"d":"2.84E-12"},{"v":1.0950631150325e-12,"d":"1.10E-12"},"GSK3B/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/GCK/MAPK3/STAT3/AKT1/PIK3R1/ESR1/HRAS/AKT2/FOS",15]
["hsa05230","Central carbon metabolism in cancer","15/130","70/8081",{"v":1.88141162848668e-13,"d":"1.88E-13"},{"v":2.84425169718281e-12,"d":"2.84E-12"},{"v":1.0950631150325e-12,"d":"1.10E-12"},"MAPK1/FGFR1/PIK3CA/GCK/MTOR/MAPK3/AKT1/PIK3R1/SLC2A1/HK2/HK1/HRAS/AKT2/HIF1A/TP53",15]
["hsa05210","Colorectal cancer","15/130","86/8081",{"v":4.57651864486737e-12,"d":"4.58E-12"},{"v":6.53425162072731e-11,"d":"6.53E-11"},{"v":2.5157470913306e-11,"d":"2.52E-11"},"BRAF/GSK3B/MAPK1/MAPK8/MAPK10/PIK3CA/MTOR/MAPK3/AKT1/PIK3R1/CASP3/HRAS/AKT2/FOS/TP53",15]
["hsa04152","AMPK signaling pathway","17/130","120/8081",{"v":5.28329868336315e-12,"d":"5.28E-12"},{"v":7.0951519330523e-11,"d":"7.10E-11"},{"v":2.73169888063451e-11,"d":"2.73E-11"},"PIK3CA/IGF1R/HMGCR/MTOR/INSR/AKT1/PIK3R1/PPARG/CFTR/AKT2/HNF4A/SIRT1/FOXO1/LIPE/PRKAA2/ACACB/GYS1",17]
["hsa05162","Measles","18/130","139/8081",{"v":5.72950956336641e-12,"d":"5.73E-12"},{"v":7.0951519330523e-11,"d":"7.10E-11"},{"v":2.73169888063451e-11,"d":"2.73E-11"},"GSK3B/TLR4/MAPK8/MAPK10/PIK3CA/TLR9/STAT3/AKT1/PIK3R1/IKBKB/CASP3/IL2/AKT2/FOS/IL6/EIF2AK3/TP53/IL1B",18]
["hsa04919","Thyroid hormone signaling pathway","17/130","121/8081",{"v":6.06495334330525e-12,"d":"6.06E-12"},{"v":7.0951519330523e-11,"d":"7.10E-11"},{"v":2.73169888063451e-11,"d":"2.73E-11"},"GSK3B/MAPK1/PIK3CA/PRKCB/MTOR/MAPK3/AKT1/PIK3R1/ESR1/SLC2A1/HRAS/AKT2/FOXO1/HIF1A/RXRG/TP53/ATP2A1",17]
["hsa04620","Toll-like receptor signaling pathway","16/130","104/8081",{"v":6.34974686615576e-12,"d":"6.35E-12"},{"v":7.0951519330523e-11,"d":"7.10E-11"},{"v":2.73169888063451e-11,"d":"2.73E-11"},"TLR4/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/TLR9/MAPK3/AKT1/PIK3R1/IKBKB/TNF/AKT2/FOS/IL6/IL1B",16]
["hsa04625","C-type lectin receptor signaling pathway","16/130","104/8081",{"v":6.34974686615576e-12,"d":"6.35E-12"},{"v":7.0951519330523e-11,"d":"7.10E-11"},{"v":2.73169888063451e-11,"d":"2.73E-11"},"MAPK14/PTGS2/MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/AKT1/PIK3R1/IKBKB/IL2/TNF/HRAS/AKT2/IL6/IL1B",16]
["hsa05235","PD-L1 expression and PD-1 checkpoint pathway in cancer","15/130","89/8081",{"v":7.69894619370445e-12,"d":"7.70E-12"},{"v":8.24428821575851e-11,"d":"8.24E-11"},{"v":3.17412693950973e-11,"d":"3.17E-11"},"TLR4/MAPK14/MAPK1/PIK3CA/TLR9/MTOR/MAPK3/STAT3/AKT1/PIK3R1/IKBKB/HRAS/AKT2/FOS/HIF1A",15]
["hsa05212","Pancreatic cancer","14/130","76/8081",{"v":1.13026611803498e-11,"d":"1.13E-11"},{"v":1.16191356933996e-10,"d":"1.16E-10"},{"v":4.47347431980162e-11,"d":"4.47E-11"},"BRAF/MAPK1/MAPK8/MAPK10/PIK3CA/MTOR/MAPK3/STAT3/AKT1/PIK3R1/IKBKB/VEGFA/AKT2/TP53",14]
["hsa04926","Relaxin signaling pathway","17/130","129/8081",{"v":1.74615497856053e-11,"d":"1.75E-11"},{"v":1.72600703650022e-10,"d":"1.73E-10"},{"v":6.64528615322633e-11,"d":"6.65E-11"},"NOS2/MAPK14/MAPK1/MAPK8/MAPK10/MMP9/PIK3CA/MAPK3/AKT1/NOS3/PIK3R1/MMP2/HRAS/VEGFA/AKT2/FOS/PRKCZ",17]
["hsa05135","Yersinia infection","17/130","137/8081",{"v":4.66452873874615e-11,"d":"4.66E-11"},{"v":4.2037225374403e-10,"d":"4.20E-10"},{"v":1.6184719169338e-10,"d":"1.62E-10"},"GSK3B/TLR4/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/AKT1/PIK3R1/IKBKB/IL2/TNF/AKT2/FOS/IL6/IL1B",17]
["hsa04151","PI3K-Akt signaling pathway","26/130","354/8081",{"v":4.66602853423384e-11,"d":"4.67E-11"},{"v":4.2037225374403e-10,"d":"4.20E-10"},{"v":1.6184719169338e-10,"d":"1.62E-10"},"GSK3B/TLR4/MAPK1/FLT1/FGFR1/PIK3CA/PIK3CG/IGF1R/MTOR/INSR/MAPK3/AKT1/NOS3/PIK3R1/IKBKB/IL2/SGK1/HRAS/VEGFA/FGF2/AKT2/IL6/PGF/TP53/PRKAA2/GYS1",26]
["hsa04920","Adipocytokine signaling pathway","13/130","69/8081",{"v":4.74350013952407e-11,"d":"4.74E-11"},{"v":4.2037225374403e-10,"d":"4.20E-10"},{"v":1.6184719169338e-10,"d":"1.62E-10"},"MAPK8/MAPK10/MTOR/STAT3/AKT1/IKBKB/SLC2A1/PPARA/TNF/AKT2/RXRG/PRKAA2/ACACB",13]
["hsa05163","Human cytomegalovirus infection","21/130","225/8081",{"v":5.166965418716e-11,"d":"5.17E-11"},{"v":4.35994495430582e-10,"d":"4.36E-10"},{"v":1.67861898711754e-10,"d":"1.68E-10"},"GSK3B/MAPK14/PTGS2/MAPK1/PIK3CA/PRKCB/MTOR/MAPK3/STAT3/AKT1/PIK3R1/IKBKB/CASP3/TNF/HRAS/VEGFA/AKT2/IL6/TP53/CCR5/IL1B",21]
["hsa04935","Growth hormone synthesis, secretion and action","16/130","119/8081",{"v":5.25907757134165e-11,"d":"5.26E-11"},{"v":4.35994495430582e-10,"d":"4.36E-10"},{"v":1.67861898711754e-10,"d":"1.68E-10"},"GSK3B/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/PRKCB/MTOR/MAPK3/STAT3/AKT1/PIK3R1/HRAS/AKT2/FOS/IGFBP3",16]
["hsa04660","T cell receptor signaling pathway","15/130","104/8081",{"v":7.85782174231573e-11,"d":"7.86E-11"},{"v":6.31081308679732e-10,"d":"6.31E-10"},{"v":2.4297211966371e-10,"d":"2.43E-10"},"GSK3B/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/AKT1/PIK3R1/IKBKB/IL2/TNF/HRAS/AKT2/FOS",15]
["hsa04370","VEGF signaling pathway","12/130","59/8081",{"v":1.06022909123423e-10,"d":"1.06E-10"},{"v":8.25693564991509e-10,"d":"8.26E-10"},{"v":3.17899631821429e-10,"d":"3.18E-10"},"MAPK14/PTGS2/MAPK1/PIK3CA/PRKCB/MAPK3/AKT1/NOS3/PIK3R1/HRAS/VEGFA/AKT2",12]
["hsa04973","Carbohydrate digestion and absorption","11/130","47/8081",{"v":1.29855869432276e-10,"d":"1.30E-10"},{"v":9.81557601296908e-10,"d":"9.82E-10"},{"v":3.77908722186809e-10,"d":"3.78E-10"},"PIK3CA/PRKCB/AKT1/PIK3R1/HK2/HK1/MGAM/SLC5A1/AKT2/AMY2A/SI",11]
["hsa04932","Non-alcoholic fatty liver disease","17/130","150/8081",{"v":2.00775560175743e-10,"d":"2.01E-10"},{"v":1.46732512207528e-09,"d":"1.47E-09"},{"v":5.6493369434805e-10,"d":"5.65E-10"},"GSK3B/MAPK8/MAPK10/PIK3CA/INSR/AKT1/PIK3R1/IKBKB/CASP3/PPARA/TNF/AKT2/FOS/IL6/EIF2AK3/PRKAA2/IL1B",17]
["hsa04010","MAPK signaling pathway","23/130","294/8081",{"v":2.05539705815993e-10,"d":"2.06E-10"},{"v":1.46732512207528e-09,"d":"1.47E-09"},{"v":5.6493369434805e-10,"d":"5.65E-10"},"BRAF/MAPK14/MAPK1/FLT1/FGFR1/MAPK8/MAPK10/IGF1R/PRKCB/INSR/MAPK3/AKT1/IKBKB/CASP3/TNF/HRAS/VEGFA/FGF2/AKT2/FOS/PGF/TP53/IL1B",23]
["hsa04657","IL-17 signaling pathway","14/130","94/8081",{"v":2.24536901862965e-10,"d":"2.25E-10"},{"v":1.55962118321032e-09,"d":"1.56E-09"},{"v":6.00468528452879e-10,"d":"6.00E-10"},"GSK3B/MAPK14/PTGS2/MAPK1/MAPK8/MAPK10/MMP9/MAPK3/IKBKB/CASP3/TNF/FOS/IL6/IL1B",14]
["hsa05145","Toxoplasmosis","15/130","112/8081",{"v":2.32009234578518e-10,"d":"2.32E-10"},{"v":1.56911508649156e-09,"d":"1.57E-09"},{"v":6.04123768708606e-10,"d":"6.04E-10"},"TLR4/NOS2/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CG/MAPK3/STAT3/AKT1/IKBKB/CASP3/TNF/AKT2/CCR5",15]
["hsa04150","mTOR signaling pathway","17/130","155/8081",{"v":3.38287343455618e-10,"d":"3.38E-10"},{"v":2.22922685302804e-09,"d":"2.23E-09"},{"v":8.58272882181594e-10,"d":"8.58E-10"},"BRAF/GSK3B/MAPK1/PIK3CA/IGF1R/PRKCB/MTOR/INSR/MAPK3/AKT1/PIK3R1/IKBKB/TNF/SGK1/HRAS/AKT2/PRKAA2",17]
["hsa04210","Apoptosis","16/130","136/8081",{"v":4.06276863060815e-10,"d":"4.06E-10"},{"v":2.61032884516573e-09,"d":"2.61E-09"},{"v":1.0050006612557e-09,"d":"1.01E-09"},"MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/AKT1/PIK3R1/IKBKB/CASP3/TNF/HRAS/AKT2/FOS/EIF2AK3/PARP2/TP53",16]
["hsa04071","Sphingolipid signaling pathway","15/130","119/8081",{"v":5.5648660462751e-10,"d":"5.56E-10"},{"v":3.48822091193341e-09,"d":"3.49E-09"},{"v":1.34299719730387e-09,"d":"1.34E-09"},"MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/PRKCB/MAPK3/AKT1/NOS3/PIK3R1/TNF/HRAS/AKT2/PRKCZ/TP53",15]
["hsa05171","Coronavirus disease - COVID-19","20/130","232/8081",{"v":6.49842931916583e-10,"d":"6.50E-10"},{"v":3.97641984529909e-09,"d":"3.98E-09"},{"v":1.53095828571826e-09,"d":"1.53E-09"},"TLR4/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/PRKCB/SELP/F2/MAPK3/STAT3/PIK3R1/IKBKB/IL2/TNF/FOS/ACE/IL6/AGTR1/IL1B",20]
["hsa04012","ErbB signaling pathway","13/130","85/8081",{"v":7.29479026980794e-10,"d":"7.29E-10"},{"v":4.35990953335033e-09,"d":"4.36E-09"},{"v":1.67860534972325e-09,"d":"1.68E-09"},"BRAF/GSK3B/MAPK1/MAPK8/MAPK10/PIK3CA/PRKCB/MTOR/MAPK3/AKT1/PIK3R1/HRAS/AKT2",13]
["hsa04015","Rap1 signaling pathway","19/130","210/8081",{"v":8.00997148094327e-10,"d":"8.01E-10"},{"v":4.67855152409641e-09,"d":"4.68E-09"},{"v":1.80128545265231e-09,"d":"1.80E-09"},"BRAF/MAPK14/MAPK1/FLT1/FGFR1/PIK3CA/IGF1R/PRKCB/INSR/MAPK3/AKT1/PIK3R1/CNR1/HRAS/VEGFA/FGF2/AKT2/PRKCZ/PGF",19]
["hsa05218","Melanoma","12/130","72/8081",{"v":1.21902864374887e-09,"d":"1.22E-09"},{"v":6.81066003137957e-09,"d":"6.81E-09"},{"v":2.62216687671382e-09,"d":"2.62E-09"},"BRAF/MAPK1/FGFR1/PIK3CA/IGF1R/MAPK3/AKT1/PIK3R1/HRAS/FGF2/AKT2/TP53",12]
["hsa05223","Non-small cell lung cancer","12/130","72/8081",{"v":1.21902864374887e-09,"d":"1.22E-09"},{"v":6.81066003137957e-09,"d":"6.81E-09"},{"v":2.62216687671382e-09,"d":"2.62E-09"},"BRAF/MAPK1/PIK3CA/PRKCB/MAPK3/STAT3/AKT1/PIK3R1/HRAS/AKT2/RXRG/TP53",12]
["hsa05224","Breast cancer","16/130","147/8081",{"v":1.30535619896894e-09,"d":"1.31E-09"},{"v":6.89586166329863e-09,"d":"6.90E-09"},{"v":2.65497029019075e-09,"d":"2.65E-09"},"BRAF/GSK3B/MAPK1/FGFR1/PIK3CA/IGF1R/MTOR/MAPK3/AKT1/PIK3R1/ESR1/HRAS/FGF2/AKT2/FOS/TP53",16]
["hsa04659","Th17 cell differentiation","14/130","107/8081",{"v":1.31355054871971e-09,"d":"1.31E-09"},{"v":6.89586166329863e-09,"d":"6.90E-09"},{"v":2.65497029019075e-09,"d":"2.65E-09"},"MAPK14/MAPK1/MAPK8/MAPK10/MTOR/MAPK3/STAT3/IKBKB/IL2/FOS/IL6/HIF1A/RXRG/IL1B",14]
["hsa04211","Longevity regulating pathway","13/130","89/8081",{"v":1.31477518094021e-09,"d":"1.31E-09"},{"v":6.89586166329863e-09,"d":"6.90E-09"},{"v":2.65497029019075e-09,"d":"2.65E-09"},"PIK3CA/IGF1R/MTOR/INSR/AKT1/PIK3R1/PPARG/HRAS/AKT2/SIRT1/FOXO1/TP53/PRKAA2",13]
["hsa05214","Glioma","12/130","75/8081",{"v":1.98989197828813e-09,"d":"1.99E-09"},{"v":1.0228044768401e-08,"d":"1.02E-08"},{"v":3.93789149387546e-09,"d":"3.94E-09"},"BRAF/MAPK1/PIK3CA/IGF1R/PRKCB/MTOR/MAPK3/AKT1/PIK3R1/HRAS/AKT2/TP53",12]
["hsa05133","Pertussis","12/130","76/8081",{"v":2.33104213970601e-09,"d":"2.33E-09"},{"v":1.17466241157734e-08,"d":"1.17E-08"},{"v":4.52255853730371e-09,"d":"4.52E-09"},"TLR4/NOS2/MAPK14/MAPK1/MAPK8/MAPK10/MAPK3/CASP3/TNF/FOS/IL6/IL1B",12]
["hsa04213","Longevity regulating pathway - multiple species","11/130","62/8081",{"v":3.08937303547251e-09,"d":"3.09E-09"},{"v":1.52686321176237e-08,"d":"1.53E-08"},{"v":5.87856407559546e-09,"d":"5.88E-09"},"PIK3CA/IGF1R/MTOR/INSR/AKT1/PIK3R1/HRAS/AKT2/SIRT1/FOXO1/PRKAA2",11]
["hsa05010","Alzheimer disease","24/130","369/8081",{"v":3.42295689250265e-09,"d":"3.42E-09"},{"v":1.64494066548119e-08,"d":"1.64E-08"},{"v":6.33317315401317e-09,"d":"6.33E-09"},"BRAF/GSK3B/BACE2/NOS2/PTGS2/MAPK1/MAPK8/MAPK10/PIK3CA/MTOR/INSR/MAPK3/AKT1/PIK3R1/IKBKB/CASP3/TNF/HRAS/AKT2/GAPDH/IL6/EIF2AK3/ATP2A1/IL1B",24]
["hsa05160","Hepatitis C","16/130","157/8081",{"v":3.45629556171144e-09,"d":"3.46E-09"},{"v":1.64494066548119e-08,"d":"1.64E-08"},{"v":6.33317315401317e-09,"d":"6.33E-09"},"BRAF/GSK3B/MAPK1/PIK3CA/MAPK3/STAT3/AKT1/PIK3R1/IKBKB/CASP3/PPARA/TNF/HRAS/AKT2/EIF2AK3/TP53",16]
["hsa05231","Choline metabolism in cancer","13/130","98/8081",{"v":4.44618007179289e-09,"d":"4.45E-09"},{"v":2.07757868809231e-08,"d":"2.08E-08"},{"v":7.99886941145515e-09,"d":"8.00E-09"},"MAPK1/MAPK8/MAPK10/PIK3CA/PRKCB/MTOR/MAPK3/AKT1/PIK3R1/HRAS/AKT2/FOS/HIF1A",13]
["hsa04722","Neurotrophin signaling pathway","14/130","119/8081",{"v":5.42603164094385e-09,"d":"5.43E-09"},{"v":2.49016094950459e-08,"d":"2.49E-08"},{"v":9.58734914001357e-09,"d":"9.59E-09"},"BRAF/GSK3B/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/AKT1/PIK3R1/IKBKB/HRAS/AKT2/TP53",14]
["hsa05170","Human immunodeficiency virus 1 infection","18/130","212/8081",{"v":6.45453924886577e-09,"d":"6.45E-09"},{"v":2.91020453852369e-08,"d":"2.91E-08"},{"v":1.12045556674678e-08,"d":"1.12E-08"},"TLR4/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/PRKCB/MTOR/MAPK3/AKT1/PIK3R1/IKBKB/CASP3/TNF/HRAS/AKT2/FOS/CCR5",18]
["hsa05221","Acute myeloid leukemia","11/130","67/8081",{"v":7.29670520528074e-09,"d":"7.30E-09"},{"v":3.23319523751233e-08,"d":"3.23E-08"},{"v":1.24480996242539e-08,"d":"1.24E-08"},"BRAF/MAPK1/PIK3CA/MTOR/MAPK3/STAT3/AKT1/PIK3R1/IKBKB/HRAS/AKT2",11]
["hsa04664","Fc epsilon RI signaling pathway","11/130","68/8081",{"v":8.58709456745163e-09,"d":"8.59E-09"},{"v":3.74048017599164e-08,"d":"3.74E-08"},{"v":1.4401193386984e-08,"d":"1.44E-08"},"MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/AKT1/PIK3R1/TNF/HRAS/AKT2",11]
["hsa05211","Renal cell carcinoma","11/130","69/8081",{"v":1.00774974182037e-08,"d":"1.01E-08"},{"v":4.31652806079726e-08,"d":"4.32E-08"},{"v":1.66190308300202e-08,"d":"1.66E-08"},"BRAF/MAPK1/PIK3CA/MAPK3/AKT1/PIK3R1/SLC2A1/HRAS/VEGFA/AKT2/HIF1A",11]
["hsa05131","Shigellosis","19/130","246/8081",{"v":1.13411837236169e-08,"d":"1.13E-08"},{"v":4.77817084749104e-08,"d":"4.78E-08"},{"v":1.83963981021568e-08,"d":"1.84E-08"},"GSK3B/TLR4/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/MTOR/MAPK3/AKT1/PIK3R1/IKBKB/HK2/HK1/TNF/AKT2/FOXO1/TP53/IL1B",19]
["hsa04072","Phospholipase D signaling pathway","15/130","148/8081",{"v":1.19294004341186e-08,"d":"1.19E-08"},{"v":4.94492888962657e-08,"d":"4.94E-08"},{"v":1.90384319322096e-08,"d":"1.90E-08"},"MAPK1/PIK3CA/PIK3CG/F2/MTOR/INSR/MAPK3/AKT1/PIK3R1/AVPR2/AVPR1A/HRAS/AKT2/AGPAT2/AGTR1",15]
["hsa05132","Salmonella infection","19/130","249/8081",{"v":1.3836910266622e-08,"d":"1.38E-08"},{"v":5.64458085479658e-08,"d":"5.64E-08"},{"v":2.17321564755633e-08,"d":"2.17E-08"},"TLR4/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/TLR9/PIK3CG/MAPK3/AKT1/IKBKB/CASP3/TNF/HRAS/AKT2/FOS/GAPDH/IL6/IL1B",19]
["hsa04380","Osteoclast differentiation","14/130","128/8081",{"v":1.41213099683138e-08,"d":"1.41E-08"},{"v":5.670588534151e-08,"d":"5.67E-08"},{"v":2.18322884378535e-08,"d":"2.18E-08"},"MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/AKT1/PIK3R1/IKBKB/PPARG/TNF/AKT2/FOS/IL1B",14]
["hsa04923","Regulation of lipolysis in adipocytes","10/130","57/8081",{"v":1.86481343006703e-08,"d":"1.86E-08"},{"v":7.37318540811118e-08,"d":"7.37E-08"},{"v":2.8387443307903e-08,"d":"2.84E-08"},"PTGS2/PIK3CA/ADRB3/INSR/AKT1/PIK3R1/FABP4/AKT2/LIPE/ADRB2",10]
["hsa05213","Endometrial cancer","10/130","58/8081",{"v":2.22286961213562e-08,"d":"2.22E-08"},{"v":8.65571955028569e-08,"d":"8.66E-08"},{"v":3.33253179490827e-08,"d":"3.33E-08"},"BRAF/GSK3B/MAPK1/PIK3CA/MAPK3/AKT1/PIK3R1/HRAS/AKT2/TP53",10]
["hsa04218","Cellular senescence","15/130","156/8081",{"v":2.45090867690975e-08,"d":"2.45E-08"},{"v":9.40124671590753e-08,"d":"9.40E-08"},{"v":3.61956662418721e-08,"d":"3.62E-08"},"MAPK14/MAPK1/PIK3CA/MTOR/MAPK3/AKT1/PIK3R1/HRAS/AKT2/SERPINE1/SIRT1/IGFBP3/IL6/FOXO1/TP53",15]
["hsa04014","Ras signaling pathway","18/130","232/8081",{"v":2.66868528899455e-08,"d":"2.67E-08"},{"v":1.00860605775235e-07,"d":"1.01E-07"},{"v":3.88322627191158e-08,"d":"3.88E-08"},"MAPK1/FLT1/FGFR1/MAPK8/MAPK10/PIK3CA/IGF1R/PRKCB/INSR/MAPK3/AKT1/PIK3R1/IKBKB/HRAS/VEGFA/FGF2/AKT2/PGF",18]
["hsa04140","Autophagy - animal","14/130","137/8081",{"v":3.40159721218076e-08,"d":"3.40E-08"},{"v":1.24887211932922e-07,"d":"1.25E-07"},{"v":4.80827275105251e-08,"d":"4.81E-08"},"MAPK1/MAPK8/MAPK10/PIK3CA/IGF1R/MTOR/MAPK3/AKT1/PIK3R1/HRAS/AKT2/HIF1A/EIF2AK3/PRKAA2",14]
["hsa04371","Apelin signaling pathway","14/130","137/8081",{"v":3.40159721218076e-08,"d":"3.40E-08"},{"v":1.24887211932922e-07,"d":"1.25E-07"},{"v":4.80827275105251e-08,"d":"4.81E-08"},"NOS2/MAPK1/PIK3CG/MTOR/MAPK3/AKT1/NOS3/PLAT/HRAS/AKT2/SERPINE1/LIPE/AGTR1/PRKAA2",14]
["hsa04662","B cell receptor signaling pathway","11/130","82/8081",{"v":6.4816791383099e-08,"d":"6.48E-08"},{"v":2.34618526555724e-07,"d":"2.35E-07"},{"v":9.03302948852677e-08,"d":"9.03E-08"},"GSK3B/MAPK1/PIK3CA/PRKCB/MAPK3/AKT1/PIK3R1/IKBKB/HRAS/AKT2/FOS",11]
["hsa05225","Hepatocellular carcinoma","15/130","168/8081",{"v":6.66195723258656e-08,"d":"6.66E-08"},{"v":2.35319748482893e-07,"d":"2.35E-07"},{"v":9.06002717894409e-08,"d":"9.06E-08"},"BRAF/GSK3B/MAPK1/PIK3CA/IGF1R/PRKCB/MTOR/MAPK3/AKT1/PIK3R1/HRAS/AKT2/HMOX1/TP53/NFE2L2",15]
["hsa05166","Human T-cell leukemia virus 1 infection","17/130","219/8081",{"v":6.68417962616779e-08,"d":"6.68E-08"},{"v":2.35319748482893e-07,"d":"2.35E-07"},{"v":9.06002717894409e-08,"d":"9.06E-08"},"MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/AKT1/PIK3R1/IKBKB/SLC2A1/IL2/TNF/HRAS/AKT2/FOS/IL6/TP53/ICAM1",17]
["hsa00500","Starch and sucrose metabolism","8/130","36/8081",{"v":7.49026876600635e-08,"d":"7.49E-08"},{"v":2.60135009846437e-07,"d":"2.60E-07"},{"v":1.00154376103072e-07,"d":"1.00E-07"},"GCK/HK2/HK1/MGAM/AMY2A/TREH/GYS1/SI",8]
["hsa05226","Gastric cancer","14/130","149/8081",{"v":9.91194440237221e-08,"d":"9.91E-08"},{"v":3.39649294854621e-07,"d":"3.40E-07"},{"v":1.30768108606735e-07,"d":"1.31E-07"},"BRAF/GSK3B/MAPK1/PIK3CA/MTOR/MAPK3/AKT1/PIK3R1/SHH/HRAS/FGF2/AKT2/RXRG/TP53",14]
["hsa04510","Focal adhesion","16/130","201/8081",{"v":1.18571962418476e-07,"d":"1.19E-07"},{"v":4.00960451862479e-07,"d":"4.01E-07"},{"v":1.54373469076686e-07,"d":"1.54E-07"},"BRAF/GSK3B/MAPK1/FLT1/MAPK8/MAPK10/PIK3CA/IGF1R/PRKCB/MAPK3/AKT1/PIK3R1/HRAS/VEGFA/AKT2/PGF",16]
["hsa05152","Tuberculosis","15/130","180/8081",{"v":1.66519989109925e-07,"d":"1.67E-07"},{"v":5.55787496120141e-07,"d":"5.56E-07"},{"v":2.13983307947136e-07,"d":"2.14E-07"},"TLR4/NOS2/MAPK14/MAPK1/MAPK8/MAPK10/TLR9/MAPK3/AKT1/VDR/CASP3/TNF/AKT2/IL6/IL1B",15]
["hsa05219","Bladder cancer","8/130","41/8081",{"v":2.2107388764064e-07,"d":"2.21E-07"},{"v":7.28410116969799e-07,"d":"7.28E-07"},{"v":2.8044460780324e-07,"d":"2.80E-07"},"BRAF/MAPK1/MMP9/MAPK3/MMP2/HRAS/VEGFA/TP53",8]
["hsa05220","Chronic myeloid leukemia","10/130","76/8081",{"v":3.1832555513679e-07,"d":"3.18E-07"},{"v":1.02706740501885e-06,"d":"1.03E-06"},{"v":3.95430416022002e-07,"d":"3.95E-07"},"BRAF/MAPK1/PIK3CA/MAPK3/AKT1/PIK3R1/IKBKB/HRAS/AKT2/TP53",10]
["hsa04024","cAMP signaling pathway","16/130","216/8081",{"v":3.19709698060342e-07,"d":"3.20E-07"},{"v":1.02706740501885e-06,"d":"1.03E-06"},{"v":3.95430416022002e-07,"d":"3.95E-07"},"BRAF/MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/AKT1/PIK3R1/PPARA/CFTR/AKT2/FOS/LIPE/ADRB2/HCAR2/ATP2A1",16]
["hsa05140","Leishmaniasis","10/130","77/8081",{"v":3.60895249411696e-07,"d":"3.61E-07"},{"v":1.14506270492353e-06,"d":"1.15E-06"},{"v":4.40859693888231e-07,"d":"4.41E-07"},"TLR4/NOS2/MAPK14/PTGS2/MAPK1/PRKCB/MAPK3/TNF/FOS/IL1B",10]
["hsa04062","Chemokine signaling pathway","15/130","192/8081",{"v":3.87091462991067e-07,"d":"3.87E-07"},{"v":1.21320129254517e-06,"d":"1.21E-06"},{"v":4.67093678063675e-07,"d":"4.67E-07"},"BRAF/GSK3B/MAPK1/PIK3CA/PIK3CG/PRKCB/MAPK3/STAT3/AKT1/PIK3R1/IKBKB/HRAS/AKT2/PRKCZ/CCR5",15]
["hsa04550","Signaling pathways regulating pluripotency of stem cells","13/130","143/8081",{"v":4.29186879247151e-07,"d":"4.29E-07"},{"v":1.32892804778937e-06,"d":"1.33E-06"},{"v":5.11649545329514e-07,"d":"5.12E-07"},"GSK3B/MAPK14/MAPK1/FGFR1/PIK3CA/IGF1R/MAPK3/STAT3/AKT1/PIK3R1/HRAS/FGF2/AKT2",13]
["hsa04914","Progesterone-mediated oocyte maturation","11/130","100/8081",{"v":5.13055223899748e-07,"d":"5.13E-07"},{"v":1.56970467312185e-06,"d":"1.57E-06"},{"v":6.04350764994691e-07,"d":"6.04E-07"},"BRAF/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/IGF1R/MAPK3/AKT1/PIK3R1/AKT2",11]
["hsa05164","Influenza A","14/130","171/8081",{"v":5.49160155377508e-07,"d":"5.49E-07"},{"v":1.66040188155317e-06,"d":"1.66E-06"},{"v":6.39270026074127e-07,"d":"6.39E-07"},"TLR4/MAPK1/PIK3CA/PRKCB/MAPK3/AKT1/PIK3R1/IKBKB/CASP3/TNF/AKT2/IL6/ICAM1/IL1B",14]
["hsa04929","GnRH secretion","9/130","64/8081",{"v":7.12974501992631e-07,"d":"7.13E-07"},{"v":2.13063310479193e-06,"d":"2.13E-06"},{"v":8.20313380505598e-07,"d":"8.20E-07"},"MAPK1/PIK3CA/PRKCB/MAPK3/AKT1/PIK3R1/HRAS/AKT2/KCNJ11",9]
["hsa04922","Glucagon signaling pathway","11/130","107/8081",{"v":1.02035948554098e-06,"d":"1.02E-06"},{"v":3.01416537682796e-06,"d":"3.01E-06"},{"v":1.16048144756022e-06,"d":"1.16E-06"},"GCK/AKT1/SLC2A1/PPARA/AKT2/GCGR/SIRT1/FOXO1/PRKAA2/ACACB/GYS1",11]
["hsa04960","Aldosterone-regulated sodium reabsorption","7/130","37/8081",{"v":1.63384121879119e-06,"d":"1.63E-06"},{"v":4.71794599134086e-06,"d":"4.72E-06"},{"v":1.8164526855869e-06,"d":"1.82E-06"},"MAPK1/PIK3CA/PRKCB/INSR/MAPK3/PIK3R1/SGK1",7]
["hsa05216","Thyroid cancer","7/130","37/8081",{"v":1.63384121879119e-06,"d":"1.63E-06"},{"v":4.71794599134086e-06,"d":"4.72E-06"},{"v":1.8164526855869e-06,"d":"1.82E-06"},"BRAF/MAPK1/MAPK3/PPARG/HRAS/RXRG/TP53",7]
["hsa04725","Cholinergic synapse","11/130","113/8081",{"v":1.76429950565284e-06,"d":"1.76E-06"},{"v":5.0380552550309e-06,"d":"5.04E-06"},{"v":1.93969770212125e-06,"d":"1.94E-06"},"MAPK1/PIK3CA/PIK3CG/PRKCB/MAPK3/KCNQ1/AKT1/PIK3R1/HRAS/AKT2/FOS",11]
["hsa05222","Small cell lung cancer","10/130","92/8081",{"v":1.93452285450083e-06,"d":"1.93E-06"},{"v":5.46343267699685e-06,"d":"5.46E-06"},{"v":2.10347192970594e-06,"d":"2.10E-06"},"NOS2/PTGS2/PIK3CA/AKT1/PIK3R1/IKBKB/CASP3/AKT2/RXRG/TP53",10]
["hsa04915","Estrogen signaling pathway","12/130","138/8081",{"v":1.96583082253058e-06,"d":"1.97E-06"},{"v":5.4915056672865e-06,"d":"5.49E-06"},{"v":2.11428028967819e-06,"d":"2.11E-06"},"MAPK1/MMP9/PIK3CA/MAPK3/AKT1/NOS3/PIK3R1/ESR1/MMP2/HRAS/AKT2/FOS",12]
["hsa05130","Pathogenic Escherichia coli infection","14/130","197/8081",{"v":3.01041967356492e-06,"d":"3.01E-06"},{"v":8.31911673232457e-06,"d":"8.32E-06"},{"v":3.20293660798079e-06,"d":"3.20E-06"},"TLR4/MAPK14/MAPK1/MAPK8/MAPK10/F2/MAPK3/IKBKB/CASP3/TNF/FOS/GAPDH/IL6/IL1B",14]
["hsa05169","Epstein-Barr virus infection","14/130","202/8081",{"v":4.04240726591612e-06,"d":"4.04E-06"},{"v":1.10521134823451e-05,"d":"1.11E-05"},{"v":4.25516554306961e-06,"d":"4.26E-06"},"MAPK14/MAPK8/MAPK10/PIK3CA/STAT3/AKT1/PIK3R1/IKBKB/CASP3/TNF/AKT2/IL6/TP53/ICAM1",14]
["hsa04611","Platelet activation","11/130","124/8081",{"v":4.41804302207465e-06,"d":"4.42E-06"},{"v":1.19519690176125e-05,"d":"1.20E-05"},{"v":4.60161821689769e-06,"d":"4.60E-06"},"MAPK14/MAPK1/PIK3CA/PIK3CG/F2/MAPK3/AKT1/NOS3/PIK3R1/AKT2/PRKCZ",11]
["hsa00052","Galactose metabolism","6/130","31/8081",{"v":8.17214013900213e-06,"d":"8.17E-06"},{"v":2.1877500163787e-05,"d":"2.19E-05"},{"v":8.42303917835746e-06,"d":"8.42E-06"},"GCK/HK2/HK1/MGAM/AKR1B1/SI",6]
["hsa05144","Malaria","7/130","50/8081",{"v":1.33233828248629e-05,"d":"1.33E-05"},{"v":3.53000967627811e-05,"d":"3.53E-05"},{"v":1.35908625668705e-05,"d":"1.36E-05"},"TLR4/TLR9/SELP/TNF/IL6/ICAM1/IL1B",7]
["hsa04520","Adherens junction","8/130","71/8081",{"v":1.64289535824482e-05,"d":"1.64E-05"},{"v":4.30840925580529e-05,"d":"4.31E-05"},{"v":1.65877726826007e-05,"d":"1.66E-05"},"MAPK1/FGFR1/IGF1R/INSR/MAPK3/YES1/PTPN1/ACP1",8]
["hsa01524","Platinum drug resistance","8/130","73/8081",{"v":2.02060078213899e-05,"d":"2.02E-05"},{"v":5.24539798999719e-05,"d":"5.25E-05"},{"v":2.01952656588055e-05,"d":"2.02E-05"},"MAPK1/PIK3CA/MAPK3/AKT1/PIK3R1/CASP3/AKT2/TP53",8]
["hsa05165","Human papillomavirus infection","17/130","331/8081",{"v":2.04449138208177e-05,"d":"2.04E-05"},{"v":5.25434285195014e-05,"d":"5.25E-05"},{"v":2.02297042016511e-05,"d":"2.02E-05"},"GSK3B/PTGS2/MAPK1/PIK3CA/MTOR/MAPK3/AKT1/PIK3R1/IKBKB/CASP3/TNF/HRAS/VEGFA/AKT2/PRKCZ/FOXO1/TP53",17]
["hsa05143","African trypanosomiasis","6/130","37/8081",{"v":2.38408711625639e-05,"d":"2.38E-05"},{"v":6.06643949384052e-05,"d":"6.07E-05"},{"v":2.33563511128818e-05,"d":"2.34E-05"},"TLR9/PRKCB/TNF/IL6/ICAM1/IL1B",6]
["hsa04750","Inflammatory mediator regulation of TRP channels","9/130","98/8081",{"v":2.57044344532388e-05,"d":"2.57E-05"},{"v":6.4765094651788e-05,"d":"6.48E-05"},{"v":2.49351582931316e-05,"d":"2.49E-05"},"MAPK14/MAPK8/MAPK10/PIK3CA/PRKCB/HRH1/PIK3R1/ALOX12/IL1B",9]
["hsa04621","NOD-like receptor signaling pathway","12/130","181/8081",{"v":3.19520175639658e-05,"d":"3.20E-05"},{"v":7.9724937028536e-05,"d":"7.97E-05"},{"v":3.06948354727929e-05,"d":"3.07E-05"},"TLR4/MAPK14/MAPK1/MAPK8/MAPK10/MAPK3/NAMPT/IKBKB/TNF/IL6/CASR/IL1B",12]
["hsa05206","MicroRNAs in cancer","16/130","310/8081",{"v":3.44137705275646e-05,"d":"3.44E-05"},{"v":8.50417213998472e-05,"d":"8.50E-05"},{"v":3.27418464533509e-05,"d":"3.27E-05"},"PTGS2/MAPK1/MMP9/PIK3CA/PRKCB/MTOR/MAPK3/STAT3/PIK3R1/IKBKB/CASP3/HRAS/VEGFA/SIRT1/HMOX1/TP53",16]
["hsa05146","Amoebiasis","9/130","102/8081",{"v":3.54409368628959e-05,"d":"3.54E-05"},{"v":8.67459121310882e-05,"d":"8.67E-05"},{"v":3.33979755900974e-05,"d":"3.34E-05"},"TLR4/NOS2/PIK3CA/PRKCB/PIK3R1/CASP3/TNF/IL6/IL1B",9]
["hsa04650","Natural killer cell mediated cytotoxicity","10/130","131/8081",{"v":4.5550026717791e-05,"d":"4.56E-05"},0.000110437328928984,{"v":4.25193893890005e-05,"d":"4.25E-05"},"BRAF/MAPK1/PIK3CA/PRKCB/MAPK3/PIK3R1/CASP3/TNF/HRAS/ICAM1",10]
["hsa04928","Parathyroid hormone synthesis, secretion and action","9/130","106/8081",{"v":4.8136823626751e-05,"d":"4.81E-05"},0.000115618352075467,{"v":4.45141310468725e-05,"d":"4.45E-05"},"BRAF/MAPK1/FGFR1/PRKCB/MAPK3/VDR/FOS/CASR/RXRG",9]
["hsa04022","cGMP-PKG signaling pathway","11/130","167/8081",{"v":7.33526434344271e-05,"d":"7.34E-05"},0.00017455212372822,{"v":6.72041762459664e-05,"d":"6.72E-05"},"MAPK1/PIK3CG/ADRB3/INSR/MAPK3/AKT1/NOS3/AKT2/AGTR1/ADRB2/ATP2A1",11]
["hsa04658","Th1 and Th2 cell differentiation","8/130","92/8081",0.000108371467880906,0.00025551804812287,{"v":9.83768032912135e-05,"d":"9.84E-05"},"MAPK14/MAPK1/MAPK8/MAPK10/MAPK3/IKBKB/IL2/FOS",8]
["hsa04912","GnRH signaling pathway","8/130","93/8081",0.000116988951220024,0.000270866310482398,0.000104286025743786,"MAPK14/MAPK1/MAPK8/MAPK10/PRKCB/MAPK3/MMP2/HRAS",8]
["hsa05323","Rheumatoid arthritis","8/130","93/8081",0.000116988951220024,0.000270866310482398,0.000104286025743786,"TLR4/FLT1/TNF/VEGFA/FOS/IL6/ICAM1/IL1B",8]
["hsa04020","Calcium signaling pathway","13/130","240/8081",0.000120816308841656,0.000275502484468377,0.000106070995453727,"NOS2/FLT1/FGFR1/ADRB3/PRKCB/HRH1/NOS3/AVPR1A/VEGFA/FGF2/AGTR1/ADRB2/ATP2A1",13]
["hsa01523","Antifolate resistance","5/130","31/8081",0.000121135333637847,0.000275502484468377,0.000106070995453727,"IKBKB/ALOX12/TNF/IL6/IL1B",5]
["hsa04261","Adrenergic signaling in cardiomyocytes","10/130","150/8081",0.000142721599785239,0.000321749571445671,0.000123876550136773,"MAPK14/MAPK1/PIK3CG/MAPK3/KCNQ1/AKT1/AKT2/AGTR1/ADRB2/ATP2A1",10]
["hsa04730","Long-term depression","6/130","60/8081",0.000379460075947388,0.000848010778421554,0.000326491964659538,"BRAF/MAPK1/IGF1R/PRKCB/MAPK3/HRAS",6]
["hsa05020","Prion disease","13/130","273/8081",0.000428172672220374,0.000948623937591692,0.00036522895815531,"GSK3B/MAPK14/MAPK1/MAPK8/MAPK10/PIK3CA/MAPK3/PIK3R1/CASP3/TNF/IL6/EIF2AK3/IL1B",13]
["hsa04614","Renin-angiotensin system","4/130","23/8081",0.000446660078973774,0.000981125130737264,0.00037774221703585,"REN/LNPEP/ACE/AGTR1",4]
["hsa05017","Spinocerebellar ataxia","9/130","143/8081",0.000473947022204118,0.00103224054835982,0.000397422123882133,"MAPK8/MAPK10/PIK3CA/PRKCB/MTOR/AKT1/PIK3R1/AKT2/ATP2A1",9]
["hsa04726","Serotonergic synapse","8/130","115/8081",0.00050579198991005,0.00109234068409145,0.000420561230000395,"BRAF/PTGS2/MAPK1/PRKCB/MAPK3/CASP3/ALOX12/HRAS",8]
["hsa05022","Pathways of neurodegeneration - multiple diseases","18/130","475/8081",0.000561546817285541,0.0012026461003532,0.00046302983179685,"BRAF/GSK3B/NOS2/MAPK14/PTGS2/MAPK1/MAPK8/MAPK10/PRKCB/MTOR/MAPK3/CASP3/TNF/HRAS/IL6/EIF2AK3/ATP2A1/IL1B",18]
["hsa05321","Inflammatory bowel disease","6/130","65/8081",0.000586352154337853,0.00124539259227131,0.000479487625121863,"TLR4/STAT3/IL2/TNF/IL6/IL1B",6]
["hsa04137","Mitophagy - animal","6/130","68/8081",0.000747058000297942,0.00157372054161124,0.000605896911371928,"MAPK8/MAPK10/HRAS/HIF1A/EIF2AK3/TP53",6]
["hsa04921","Oxytocin signaling pathway","9/130","154/8081",0.000811153394238321,0.00169484896194511,0.000652532469477126,"PTGS2/MAPK1/PIK3CG/PRKCB/MAPK3/NOS3/HRAS/FOS/PRKAA2",9]
["hsa04666","Fc gamma R-mediated phagocytosis","7/130","97/8081",0.000916803748735246,0.00190014970503999,0.00073157514754765,"MAPK1/PIK3CA/PRKCB/MAPK3/AKT1/PIK3R1/AKT2",7]
["hsa05202","Transcriptional misregulation in cancer","10/130","192/8081",0.00102096284752286,0.00209909961450701,0.000808172696144414,"FLT1/MMP9/IGF1R/PPARG/PLAT/IGFBP3/IL6/FOXO1/RXRG/TP53",10]
["hsa04630","JAK-STAT signaling pathway","9/130","162/8081",0.00116264642535005,0.00237142961361081,0.000913022255496277,"PIK3CA/MTOR/STAT3/AKT1/PIK3R1/IL2/HRAS/AKT2/IL6",9]
["hsa04728","Dopaminergic synapse","8/130","132/8081",0.00125413372925362,0.00253789266471008,0.000977112064234066,"GSK3B/MAPK14/MAPK8/MAPK10/PRKCB/AKT1/AKT2/FOS",8]
["hsa04064","NF-kappa B signaling pathway","7/130","104/8081",0.00138178990429346,0.00277437504221422,0.00106815995891106,"TLR4/PTGS2/PRKCB/IKBKB/TNF/ICAM1/IL1B",7]
["hsa05203","Viral carcinogenesis","10/130","204/8081",0.00161425158250586,0.00321598958685276,0.00123818562836027,"MAPK1/PIK3CA/MAPK3/STAT3/PIK3R1/CASP3/HDAC11/HRAS/TP53/CCR5",10]
["hsa00051","Fructose and mannose metabolism","4/130","33/8081",0.00182286836700841,0.00360367054093201,0.00138744636841126,"HK2/HK1/AKR1B1/SORD",4]
["hsa05134","Legionellosis","5/130","57/8081",0.0021380841317354,0.00419456199890075,0.0016149450251758,"TLR4/CASP3/TNF/IL6/IL1B",5]
["hsa04670","Leukocyte transendothelial migration","7/130","114/8081",0.00234475247136203,0.00456516200863667,0.00175762944424267,"MAPK14/MMP9/PIK3CA/PRKCB/PIK3R1/MMP2/ICAM1",7]
["hsa04723","Retrograde endocannabinoid signaling","8/130","148/8081",0.00259030295089631,0.0050053222434613,0.00192709519101111,"MAPK14/PTGS2/MAPK1/MAPK8/MAPK10/PRKCB/MAPK3/CNR1",8]
["hsa04976","Bile secretion","6/130","90/8081",0.0031886892621565,0.00611562045055389,0.00235457023285712,"HMGCR/SLC2A1/CFTR/SLC5A1/CYP3A4/NR0B2",6]
["hsa04080","Neuroactive ligand-receptor interaction","13/130","341/8081",0.00323616281722635,0.00616069514094201,0.00237192440404894,"ADRB3/MCHR1/F2/MTNR1B/HRH1/CNR1/AVPR2/AVPR1A/TAAR1/GCGR/AGTR1/ADRB2/MC4R",13]
["hsa00010","Glycolysis / Gluconeogenesis","5/130","67/8081",0.00434077462164171,0.00814291297636438,0.00313509653810465,"GCK/HK2/HK1/ALDH2/GAPDH",5]
["hsa04720","Long-term potentiation","5/130","67/8081",0.00434077462164171,0.00814291297636438,0.00313509653810465,"BRAF/MAPK1/PRKCB/MAPK3/HRAS",5]
["hsa05332","Graft-versus-host disease","4/130","42/8081",0.00446082731803625,0.00830748275895156,0.0031984574210176,"IL2/TNF/IL6/IL1B",4]
["hsa04924","Renin secretion","5/130","69/8081",0.00492430446392486,0.00910464926063805,0.00350537387057128,"REN/ADRB3/ACE/AGTR1/ADRB2",5]
["hsa04622","RIG-I-like receptor signaling pathway","5/130","70/8081",0.00523603591087703,0.00954369666025104,0.00367441116552774,"MAPK14/MAPK8/MAPK10/IKBKB/TNF",5]
["hsa05120","Epithelial cell signaling in Helicobacter pylori infection","5/130","70/8081",0.00523603591087703,0.00954369666025104,0.00367441116552774,"MAPK14/MAPK8/MAPK10/IKBKB/CASP3",5]
["hsa04972","Pancreatic secretion","6/130","102/8081",0.00590019549975425,0.0106785228411045,0.00411132970331282,"PRKCB/KCNQ1/CFTR/CTRB1/AMY2A/ATP2A1",6]
["hsa03320","PPAR signaling pathway","5/130","76/8081",0.00740576140163235,0.0133096551064302,0.00512433987304705,"PPARG/PPARA/FABP4/FABP2/RXRG",5]
["hsa04810","Regulation of actin cytoskeleton","9/130","218/8081",0.0084124138003913,0.0150138218520872,0.00578045977512267,"BRAF/MAPK1/FGFR1/PIK3CA/F2/MAPK3/PIK3R1/HRAS/FGF2",9]
["hsa04913","Ovarian steroidogenesis","4/130","51/8081",0.00891459016834912,0.0157285975837961,0.00605565501895076,"PTGS2/IGF1R/INSR/CYP19A1",4]
["hsa04360","Axon guidance","8/130","182/8081",0.00893531224604756,0.0157285975837961,0.00605565501895076,"GSK3B/MAPK1/PIK3CA/MAPK3/PIK3R1/SHH/HRAS/PRKCZ",8]
["hsa04714","Thermogenesis","9/130","231/8081",0.0120213578728387,0.0210169317912894,0.00809171242425231,"MAPK14/FGFR1/ADRB3/MTOR/CNR1/PPARG/HRAS/LIPE/PRKAA2",9]
["hsa04215","Apoptosis - multiple species","3/130","32/8081",0.0143587043138495,0.0249336960044548,0.00959970274183392,"MAPK8/MAPK10/CASP3",3]
["hsa04978","Mineral absorption","4/130","59/8081",0.0147186921818383,0.0252806526293612,0.00973328423985236,"VDR/SLC5A1/HMOX1/TRPM6",4]
["hsa05410","Hypertrophic cardiomyopathy","5/130","90/8081",0.0147552447253081,0.0252806526293612,0.00973328423985236,"TNF/ACE/IL6/PRKAA2/ATP2A1",5]
["hsa05217","Basal cell carcinoma","4/130","63/8081",0.0183446293844469,0.0312223162371049,0.0120208794851029,"GSK3B/SHH/GLI2/TP53",4]
["hsa04713","Circadian entrainment","5/130","97/8081",0.0198083855346159,0.0334918097526072,0.0128946554034203,"MAPK1/PRKCB/MTNR1B/MAPK3/FOS",5]
["hsa04270","Vascular smooth muscle contraction","6/130","133/8081",0.0201261877300894,0.033806733638124,0.0130159040015714,"BRAF/MAPK1/PRKCB/MAPK3/AVPR1A/AGTR1",6]
["hsa04916","Melanogenesis","5/130","101/8081",0.0231507163160217,0.0386346369689453,0.0148746912761862,"GSK3B/MAPK1/PRKCB/MAPK3/HRAS",5]
["hsa04115","p53 signaling pathway","4/130","73/8081",0.029677977435076,0.0492080012955777,0.0189455339823236,"CASP3/SERPINE1/IGFBP3/TP53",4]