OUTCOME: Clavien-Dindo grade I-II complications ANALYSIS: primary_all_designs STUDIES: 7 TREATMENTS: Conventional, Retzius, Ultra Original data: treat1 treat2 TE seTE Beyatli_2025 Retzius Ultra 0.3051 0.4984 Eden_2017 Conventional Retzius 1.6601 1.5655 Karsiyakali_2022 Conventional Retzius 0.8581 1.1622 Lambert_2023 Conventional Retzius 0.8723 0.4140 Lim_2014 Conventional Retzius 0.9808 0.8620 Yee_2021 Conventional Retzius 0.4477 0.6740 Yilmaz_2023 Conventional Retzius -0.0000 0.6606 Number of treatment arms (by study): narms Beyatli_2025 2 Eden_2017 2 Karsiyakali_2022 2 Lambert_2023 2 Lim_2014 2 Yee_2021 2 Yilmaz_2023 2 Results (random effects model): treat1 treat2 OR 95%-CI Beyatli_2025 Retzius Ultra 1.3567 [0.5108; 3.6037] Eden_2017 Conventional Retzius 1.9722 [1.1409; 3.4093] Karsiyakali_2022 Conventional Retzius 1.9722 [1.1409; 3.4093] Lambert_2023 Conventional Retzius 1.9722 [1.1409; 3.4093] Lim_2014 Conventional Retzius 1.9722 [1.1409; 3.4093] Yee_2021 Conventional Retzius 1.9722 [1.1409; 3.4093] Yilmaz_2023 Conventional Retzius 1.9722 [1.1409; 3.4093] Number of studies: k = 7 Number of pairwise comparisons: m = 7 Number of observations: o = 975 Number of treatments: n = 3 Number of designs: d = 2 Random effects model Treatment estimate (sm = 'OR', comparison: other treatments vs 'Conventional'): OR 95%-CI z p-value Conventional . . . . Retzius 0.5071 [0.2933; 0.8765] -2.43 0.0150 Ultra 0.3737 [0.1220; 1.1452] -1.72 0.0850 Quantifying heterogeneity / inconsistency: tau^2 < 0.0001; tau < 0.0001; I^2 = 0% [0.0%; 74.6%] Tests of heterogeneity (within designs) and inconsistency (between designs): Q d.f. p-value Total 1.93 5 0.8585 Within designs 1.93 5 0.8585 Between designs 0.00 0 -- Details of network meta-analysis methods: - Frequentist graph-theoretical approach - Restricted maximum-likelihood estimator for tau^2 - Calculation of I^2 based on Q --- P-SCORE RANKING --- P-score Ultra 0.8436 Retzius 0.6314 Conventional 0.0250 --- SUCRA RANKING --- SUCRA Ultra 0.8434 Retzius 0.6328 Conventional 0.0238 - based on 20000 simulations --- GLOBAL INCONSISTENCY: DESIGN-BY-TREATMENT --- Q statistics to assess homogeneity / consistency Q df p-value Total 1.93 5 0.8585 Within designs 1.93 5 0.8585 Between designs 0.00 0 -- Design-specific decomposition of within-designs Q statistic Design Q df p-value Conventional:Retzius 1.93 5 0.8585 Q statistic to assess consistency under the assumption of a full design-by-treatment interaction random effects model Q df p-value tau.within tau2.within Between designs 0.00 0 -- 0 0 --- LOCAL INCONSISTENCY: NODE SPLITTING/SIDE --- Separate indirect from direct evidence (SIDE) using back-calculation method Random effects model: comparison k prop nma direct indir. RoR z p-value Retzius:Conventional 6 1.00 0.5071 0.5071 . . . . Ultra:Conventional 0 0 0.3737 . 0.3737 . . . Retzius:Ultra 1 1.00 1.3567 1.3567 . . . . Legend: comparison - Treatment comparison k - Number of studies providing direct evidence prop - Direct evidence proportion nma - Estimated treatment effect (OR) in network meta-analysis direct - Estimated treatment effect (OR) derived from direct evidence indir. - Estimated treatment effect (OR) derived from indirect evidence RoR - Ratio of Ratios (direct versus indirect) z - z-value of test for disagreement (direct versus indirect) p-value - p-value of test for disagreement (direct versus indirect)