OUTCOME: Urinary continence at 2 weeks ANALYSIS: primary_all_designs STUDIES: 4 TREATMENTS: Conventional, Retzius, Ultra Original data: treat1 treat2 TE seTE Kwon_2014 Conventional Ultra -0.1409 0.3756 Lambert_2023 Conventional Retzius -2.4120 0.3469 Maruyama_2020 Conventional Retzius -0.8913 1.5214 Yee_2021 Conventional Retzius 1.0544 0.6079 Number of treatment arms (by study): narms Kwon_2014 2 Lambert_2023 2 Maruyama_2020 2 Yee_2021 2 Results (random effects model): treat1 treat2 OR 95%-CI Kwon_2014 Conventional Ultra 0.8686 [0.0235; 32.1219] Lambert_2023 Conventional Retzius 0.4600 [0.0480; 4.4072] Maruyama_2020 Conventional Retzius 0.4600 [0.0480; 4.4072] Yee_2021 Conventional Retzius 0.4600 [0.0480; 4.4072] Number of studies: k = 4 Number of pairwise comparisons: m = 4 Number of observations: o = 568 Number of treatments: n = 3 Number of designs: d = 2 Random effects model Treatment estimate (sm = 'OR', comparison: other treatments vs 'Conventional'): OR 95%-CI z p-value Conventional . . . . Retzius 2.1740 [0.2269; 20.8287] 0.67 0.5006 Ultra 1.1513 [0.0311; 42.5785] 0.08 0.9390 Quantifying heterogeneity / inconsistency: tau^2 = 3.2522; tau = 1.8034; I^2 = 91.9% [79.5%; 96.8%] Tests of heterogeneity (within designs) and inconsistency (between designs): Q d.f. p-value Total 24.71 2 < 0.0001 Within designs 24.71 2 < 0.0001 Between designs 0.00 0 -- Details of network meta-analysis methods: - Frequentist graph-theoretical approach - Restricted maximum-likelihood estimator for tau^2 - Calculation of I^2 based on Q --- P-SCORE RANKING --- P-score Retzius 0.6824 Ultra 0.4577 Conventional 0.3599 --- SUCRA RANKING --- SUCRA Retzius 0.6815 Ultra 0.4580 Conventional 0.3604 - based on 20000 simulations --- GLOBAL INCONSISTENCY: DESIGN-BY-TREATMENT --- Q statistics to assess homogeneity / consistency Q df p-value Total 24.71 2 < 0.0001 Within designs 24.71 2 < 0.0001 Between designs 0.00 0 -- Design-specific decomposition of within-designs Q statistic Design Q df p-value Conventional:Retzius 24.71 2 < 0.0001 Q statistic to assess consistency under the assumption of a full design-by-treatment interaction random effects model Q df p-value tau.within tau2.within Between designs 0.00 0 -- 2.1845 4.7718 --- LOCAL INCONSISTENCY: NODE SPLITTING/SIDE --- Separate indirect from direct evidence (SIDE) using back-calculation method Random effects model: comparison k prop nma direct indir. RoR z p-value Retzius:Conventional 3 1.00 2.1740 2.1740 . . . . Ultra:Conventional 1 1.00 1.1513 1.1513 . . . . Retzius:Ultra 0 0 1.8882 . 1.8882 . . . Legend: comparison - Treatment comparison k - Number of studies providing direct evidence prop - Direct evidence proportion nma - Estimated treatment effect (OR) in network meta-analysis direct - Estimated treatment effect (OR) derived from direct evidence indir. - Estimated treatment effect (OR) derived from indirect evidence RoR - Ratio of Ratios (direct versus indirect) z - z-value of test for disagreement (direct versus indirect) p-value - p-value of test for disagreement (direct versus indirect)