                                  Characteristic             ¡Ü1.9          2.1¨C3.0          3.8¨C5.9     8.6 (capped)          Overall Missing Max SMD

                   Patients (one operation each)              815              570              765              215             2365                

                                      Age, years       65 (55¨C70)       65 (55¨C75)       65 (55¨C75)       60 (40¨C70)       65 (55¨C70)       0    0.46

                               Female sex, n (%)       257 (31.5)       245 (43.0)       328 (42.9)        83 (38.6)       913 (38.6)       0    0.24

                                      Weight, kg 65.0 (55.0¨C70.0) 60.0 (55.0¨C70.0) 60.0 (50.0¨C70.0) 60.0 (55.0¨C70.0) 60.0 (55.0¨C70.0)       4    0.18

                   ASA physical status ¡Ý3, n (%)       540 (67.0)       379 (66.8)       531 (70.6)       144 (68.6)      1594 (68.3)      30    0.08

                      Emergency operation, n (%)        83 (10.2)         45 (7.9)        97 (12.7)        25 (11.6)       250 (10.6)       0    0.16

                               CPB duration, min    190 (140¨C230)    190 (141¨C235)    200 (155¨C255)    220 (180¨C262)    195 (150¨C240)       0    0.64

           CPB separation to end of surgery, min      95 (75¨C110)      90 (75¨C120)     110 (80¨C155)     140 (95¨C200)     100 (75¨C135)       0    0.86

                  Preoperative creatinine, mg/dL 0.88 (0.74¨C1.15) 0.88 (0.74¨C1.05) 0.88 (0.74¨C1.05) 0.92 (0.79¨C1.05) 0.88 (0.74¨C1.05)       0    0.09

Lactate results in the 0¨C24 h exposure window, n          3 (1¨C7)          6 (2¨C8)         8 (6¨C10)        10 (8¨C13)          7 (2¨C9)       0    1.62

        Creatinine results after the landmark, n          6 (5¨C8)          6 (5¨C9)         7 (5¨C11)         9 (5¨C13)         7 (5¨C10)       4    0.58

           Concurrent AKI at the landmark, n (%)       101 (12.4)        94 (16.5)       224 (29.3)       112 (52.1)       531 (22.5)       0    0.94



Max SMD is the largest standardised difference among the six pairwise

stratum comparisons. Values above 0.10 indicate imbalance worth noting.

Missing is the number of patients with no recorded value (STROBE 14b);

all summaries and percentages are over patients with the value recorded.



Outputs: <local path>\analysis\results\manuscript_v3

