====================================================================================================
MANUSCRIPT NUMBER AUDIT
====================================================================================================
[  ok  ] primary cohort patients = 2,365
[  ok  ] eligible operations = 2,468
[  ok  ] patients with repeat operations = 98
[  ok  ] first operations whose window overlaps next = 21
[  ok  ] primary: met AKI criteria = 727
[  ok  ] primary: concurrent = 531
[  ok  ] primary: concurrent share = 73.0%
[  ok  ] primary: at risk = 1,834
[  ok  ] primary: newly detected = 196
[  ok  ] all operations: concurrent share = 73.4%
[  ok  ] all operations: 570 of 777
[  ok  ] primary top-stratum cause-specific HR = 2.13
[  ok  ] primary top-stratum HR CI = 1.22-3.74
[  ok  ] primary 3.8-5.9 HR = 1.48 (1.04-2.10)
[  ok  ] primary trend HR = 1.25 (1.08-1.45)
[  ok  ] all-operations cluster-robust top HR = 2.04 (1.17-3.58)
[  ok  ] day-5 cumulative incidence, <=1.9 = 9.0%
[  ok  ] day-5 cumulative incidence, 2.1-3.0 = 9.9%
[  ok  ] day-5 cumulative incidence, 3.8-5.9 = 12.5%
[  ok  ] day-5 cumulative incidence, 8.6 capped = 15.6%
[  ok  ] day-1 cumulative incidence, <=1.9 = 5.6%
[  ok  ] day-1 cumulative incidence, 2.1-3.0 = 6.6%
[  ok  ] day-1 cumulative incidence, 3.8-5.9 = 9.1%
[  ok  ] day-1 cumulative incidence, 8.6 capped = 13.6%
[  ok  ] events detected 0-24 h after landmark = 134
[  ok  ] of those, absolute limb involved = 131
[  ok  ] events 24-48 h = 28
[  ok  ] events >48 h = 34
[  ok  ] no absolute-limb events beyond 24 h after landmark
[  ok  ] events detected later than 24 h = 62
[  ok  ] ascertainable subset n = 1,109
[  ok  ] ascertainable subset events = 196
[  ok  ] ascertainable top-stratum OR = 1.77 (0.93-3.37)
[  ok  ] ascertainable absolute risk, <=1.9 = 14.6%
[  ok  ] ascertainable absolute risk, 2.1-3.0 = 16.9%
[  ok  ] ascertainable absolute risk, 3.8-5.9 = 21.4%
[  ok  ] ascertainable absolute risk, 8.6 capped = 22.9%
[  ok  ] primary cohort deaths = 90
[  ok  ] 90-day mortality, <=1.9 = 1.4%
[  ok  ] 90-day mortality, 2.1-3.0 = 3.0%
[  ok  ] 90-day mortality, 3.8-5.9 = 5.2%
[  ok  ] 90-day mortality, 8.6 capped = 10.2%
[  ok  ] Firth expanded lac_2.1-3.0 = 2.25 (1.05-5.01)
[  ok  ] Firth expanded lac_3.8-5.9 = 3.32 (1.71-6.95)
[  ok  ] Firth expanded lac_8.6 capped = 7.34 (3.35-16.84)
[  ok  ] Firth parsimonious lac_8.6 capped = 12.25 (5.84-27.1)
[  ok  ] all-operations Firth expanded top OR = 8.62 (4.12-19.10)
[  ok  ] all-operations deaths = 105
[  ok  ] expanded maximum-likelihood top OR = 7.64
[  ok  ] expanded ridge top OR = 6.46
[  ok  ] events per variable, parsimonious = 15.0
[  ok  ] events per variable, expanded = 9.0
[  ok  ] bootstrap optimism, parsimonious = 0.011
[  ok  ] bootstrap optimism, expanded = 0.018
[  ok  ] optimism-corrected C-index, parsimonious = 0.788
[  ok  ] optimism-corrected C-index, expanded = 0.812
[  ok  ] censoring hazard ratio, lac_2.1-3.0 = 0.93
[  ok  ] censoring P, lac_2.1-3.0 = 0.23
[  ok  ] censoring hazard ratio, lac_3.8-5.9 = 0.93
[  ok  ] censoring P, lac_3.8-5.9 = 0.24
[  ok  ] censoring hazard ratio, lac_8.6 capped = 0.8
[  ok  ] censoring P, lac_8.6 capped = 0.05
[  ok  ] IPCW moves top-stratum OR from 1.77 to 1.59
[  ok  ] IPCW top-stratum CI = 0.91-2.76
[  ok  ] tipping point delta = 0.23
[  ok  ] incremental C-index ascertainable/parsimonious = 0.021
[  ok  ] incremental CI ascertainable/parsimonious = (-0.034, 0.068)
[  ok  ] incremental C-index ascertainable/expanded = 0.001
[  ok  ] incremental CI ascertainable/expanded = (-0.035, 0.027)
[  ok  ] incremental C-index full risk set/parsimonious = 0.009
[  ok  ] incremental CI full risk set/parsimonious = (-0.027, 0.037)
[  ok  ] incremental C-index full risk set/expanded = -0.001
[  ok  ] incremental CI full risk set/expanded = (-0.026, 0.017)
[  ok  ] incremental C-index 24 h/parsimonious = 0.023
[  ok  ] incremental CI 24 h/parsimonious = (-0.029, 0.062)
[  ok  ] incremental C-index 24 h/expanded = 0.011
[  ok  ] incremental CI 24 h/expanded = (-0.031, 0.04)
[  ok  ] incremental C-index mortality/parsimonious = 0.065
[  ok  ] incremental CI mortality/parsimonious = (-0.008, 0.119)
[  ok  ] incremental C-index mortality/expanded = 0.024
[  ok  ] incremental CI mortality/expanded = (-0.019, 0.057)
[  ok  ] every incremental interval includes zero
[  ok  ] concurrent fraction at 6 h = 6.7%
[  ok  ] concurrent fraction at 12 h = 34.1%
[  ok  ] concurrent fraction at 24 h = 73.0%
[  ok  ] concurrent fraction at 48 h = 91.5%
[  ok  ] top-stratum concurrent at 24 h = 87.5%
[  ok  ] bottom-stratum concurrent at 24 h = 62.0%
[  ok  ] no-landmark OR = 6.31 (4.46-8.93)
[  ok  ] landmark OR at 24 h = 2.18 (1.16-4.07)
[  ok  ] ratio of odds ratios = 2.90
[  ok  ] Fine-Gray largest relative difference = 0.0045%
[  ok  ] CPB separation to end of surgery, median = 100 min
[  ok  ] IQR 75-135
[  ok  ] range 10-620
[  ok  ] Table 1 missing count, ASA physical status 3, n (%) = 30
[  ok  ] Table 1 missing count, Weight, kg = 4
[  ok  ] Table 1 missing count, Creatinine results after the landmark, n = 4
[  ok  ] Table 1 missing count, Age, years = 0
[  ok  ] Table 1 missing count, Female sex, n (%) = 0
[  ok  ] Table 1 missing count, Emergency operation, n (%) = 0
[  ok  ] Table 1 missing count, CPB duration, min = 0
[  ok  ] Table 1 missing count, Preoperative creatinine, mg/dL = 0
[  ok  ] Table 1 missing count, Lactate results in the 0C24 h exposure window, n = 0
[  ok  ] Table 1 missing count, Concurrent AKI at the landmark, n (%) = 0
[  ok  ] Table 1 ASA >=3 overall = 1594 (68.3), over recorded values only
[  ok  ] ASA missing fraction = 1.3%
[  ok  ] ASA sensitivity, published top-stratum HR = 2.13
[  ok  ] ASA sensitivity, complete-case top-stratum HR = 2.07
[  ok  ] ASA sensitivity, complete-case CI = 1.16-3.68
[  ok  ] ASA sensitivity, missing-indicator top-stratum HR = 2.13
[  ok  ] ASA sensitivity, missing-indicator CI = 1.22-3.73
[  ok  ] ASA sensitivity, trend HR = 1.25 under all three specifications
[  ok  ] ASA missing in the at-risk set = 17 patients
[  ok  ] events among them = 4
[  ok  ] preoperative creatinine median, three lower strata = 0.88
[  ok  ] preoperative creatinine median, top stratum = 0.92
[  ok  ] baseline creatinine max SMD, primary cohort = 0.09
[  ok  ] baseline creatinine max SMD, at-risk subset = 0.05
[  ok  ] baseline creatinine Kruskal-Wallis P, primary cohort = 0.063
[  ok  ] baseline creatinine Kruskal-Wallis P, at-risk subset = 0.66
[  ok  ] Table 1 preoperative creatinine SMD agrees with the standalone test

122 of 122 checks passed.

====================================================================================================
SWEEP FOR VALUES THAT BELONGED TO SUPERSEDED ANALYSES
====================================================================================================
  No retired values or phrases found in the manuscript.

Audit written to analysis\results\manuscript_v3\number_audit.csv
