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A. CENSORING HAZARD, PRIMARY COHORT

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Cox model for the hazard of losing renal follow-up. A non-significant

coefficient does not establish independent censoring; it means no clear

lactate-related difference was detected in the modelled endpoint.



          term  HR_censoring        ci      p

   lac_2.1-3.0         0.927 0.82-1.05 0.2306

   lac_3.8-5.9         0.930 0.82-1.05 0.2382

lac_8.6 capped         0.796  0.63-1.0 0.0501



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B. IPCW REFITTED ON THE CORRECTED ASCERTAINABILITY INDICATOR

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ascertainable subset: n=1109, events=196

IPCW weights: median 1.445, range 1.026-8.607



  analysis    n  events           term   OR        ci      p

unweighted 1109     196    lac_2.1-3.0 1.15 0.76-1.74 0.5131

unweighted 1109     196    lac_3.8-5.9 1.57 1.06-2.31 0.0235

unweighted 1109     196 lac_8.6 capped 1.77 0.93-3.37 0.0822

      IPCW 1109     196    lac_2.1-3.0 1.18 0.85-1.65 0.3252

      IPCW 1109     196    lac_3.8-5.9 1.58 1.16-2.16 0.0035

      IPCW 1109     196 lac_8.6 capped 1.59 0.91-2.76 0.1006



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C. TIPPING POINT AND EXTREME BOUNDS, PRIMARY COHORT

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patients with unascertainable status by stratum: [288, 186, 218, 33]

observed events by stratum                     : [62, 49, 69, 16]



                                            scenario  risk_<=1.9  risk_2.1-3.0  risk_3.8-5.9  risk_8.6 capped  trend_z  trend_p

                      hidden patients are non-events        8.68         10.29         12.75            15.53    2.813 0.004913

        hidden patients all develop AKI (worst case)       49.02         49.37         53.05            47.57    0.903 0.366598

hidden risk equals observed risk in the same stratum       12.19         14.32         17.89            20.51    3.243 0.001181



Tipping point: the trend loses significance at delta = 0.23

 delta  trend_z  trend_p

  0.00    2.813   0.0049

  0.05    2.550   0.0108

  0.10    2.340   0.0193

  0.20    2.019   0.0435

  0.30    1.780   0.0751

  0.50    1.435   0.1514

  1.00    0.903   0.3666



Outputs: <local path>\analysis\results\manuscript_v3

