
==============================================================================
A. WHAT IS CENSORING ACTUALLY MADE OF?
==============================================================================
lactate_stratum  n_at_risk  events  competing_deaths  censored  censored_discharged_in_window  censored_still_in_hospital  pct_of_censoring_from_discharge  median_followup_discharged  median_followup_in_hospital
          <=1.9        714      62                 1       651                            152                         499                             23.3                        3.64                         5.69
        2.1-3.0        476      49                 1       426                             73                         353                             17.1                        3.56                         5.64
        3.8-5.9        541      69                 4       468                             60                         408                             12.8                        2.79                         5.59
     8.6 capped        103      16                 1        86                              7                          79                              8.1                        2.93                         5.66
     all strata       1834     196                 7      1631                            292                        1339                             17.9                        3.57                         5.64

  Of 1631 censored patients, 292 (17.9%) had left hospital within the window.
  The remaining 1339 were still inpatients when the window closed;
  their follow-up ends because creatinine stopped being drawn, not because they went home.

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B. EVENT STRUCTURE UNDER EACH ASSUMPTION
==============================================================================
                                variant    n  aki_events  competing  censored
  A death only competing (as published) 1834         196          7      1631
             B discharge also competing 1834         196        299      1339
C all censoring competing (lower bound) 1834         196       1638         0

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C. EFFECT ESTIMATES UNDER EACH ASSUMPTION
==============================================================================
                                variant          estimator    n  events  competing  2.1-3.0 2.1-3.0 95% CI  3.8-5.9 3.8-5.9 95% CI  8.6 capped 8.6 capped 95% CI  trend trend 95% CI  trend p
  A death only competing (as published)  cause-specific HR 1834     196        NaN    1.159      0.79-1.69    1.482      1.04-2.10       2.135         1.22-3.74  1.251    1.08-1.45   0.0034
  A death only competing (as published) subdistribution HR 1834     196        7.0    1.159      0.79-1.69    1.479      1.04-2.10       2.116         1.21-3.70  1.249    1.08-1.45   0.0037
             B discharge also competing  cause-specific HR 1834     196        NaN    1.166      0.80-1.70    1.487      1.05-2.11       2.164         1.24-3.79  1.255    1.08-1.46   0.0030
             B discharge also competing subdistribution HR 1834     196      299.0    1.171      0.80-1.71    1.496      1.05-2.12       2.170         1.24-3.80  1.258    1.08-1.46   0.0028
C all censoring competing (lower bound)  cause-specific HR 1834     196        NaN    1.159      0.79-1.69    1.482      1.04-2.10       2.135         1.22-3.74  1.251    1.08-1.45   0.0034
C all censoring competing (lower bound) subdistribution HR 1834     196     1638.0    1.166      0.80-1.70    1.489      1.05-2.11       2.182         1.25-3.82  1.257    1.08-1.46   0.0029

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D. DAY-5 CUMULATIVE INCIDENCE OF AKI UNDER EACH ASSUMPTION
==============================================================================
                                variant lactate_stratum   n  at_risk_at_horizon  at_risk_pct  cif_pct  ci_low_pct  ci_high_pct
  A death only competing (as published)           <=1.9 714                 365         51.1     8.96        6.80        11.13
  A death only competing (as published)         2.1-3.0 476                 245         51.5     9.87        7.12        12.63
  A death only competing (as published)         3.8-5.9 541                 259         47.9    12.54        9.67        15.41
  A death only competing (as published)      8.6 capped 103                  54         52.4    15.58        8.56        22.59
             B discharge also competing           <=1.9 714                 444         62.2     8.65        6.57        10.72
             B discharge also competing         2.1-3.0 476                 278         58.4     9.62        6.94        12.30
             B discharge also competing         3.8-5.9 541                 299         55.3    12.30        9.49        15.11
             B discharge also competing      8.6 capped 103                  58         56.3    15.58        8.56        22.59
C all censoring competing (lower bound)           <=1.9 714                 365         51.1     8.54        6.49        10.59
C all censoring competing (lower bound)         2.1-3.0 476                 245         51.5     9.45        6.83        12.08
C all censoring competing (lower bound)         3.8-5.9 541                 259         47.9    12.01        9.27        14.75
C all censoring competing (lower bound)      8.6 capped 103                  54         52.4    15.53        8.54        22.53

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E. NUMBERS AT RISK BY HORIZON (audit of the day-5 truncation)
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  longest observed follow-up: 5.99 days; the renal window closes 6.00 days past the landmark, and no patient reaches it
  observation ends in the final 12 hours for 855 of 1834 patients (46.6%), of whom 846 (46.1%) are censored rather than reaching an event
lactate_stratum   n  at_risk_day1  pct_day1  at_risk_day2  pct_day2  at_risk_day3  pct_day3  at_risk_day4  pct_day4  at_risk_day5  pct_day5  at_risk_day5_5  pct_day5_5
          <=1.9 714           663      92.9           620      86.8           594      83.2           450      63.0           365      51.1             339        47.5
        2.1-3.0 476           435      91.4           408      85.7           377      79.2           310      65.1           245      51.5             228        47.9
        3.8-5.9 541           476      88.0           442      81.7           410      75.8           343      63.4           259      47.9             238        44.0
     8.6 capped 103            88      85.4            83      80.6            78      75.7            68      66.0            54      52.4              50        48.5

written to results\manuscript_v3
