DATA AVAILABILITY — Paper 1
"A conservation–divergence spectrum reads subtype specificity from sequence as a sparse, distributed, probabilistic code across protein superfamilies"

All data underlying the findings are within the manuscript and its supplementary datasets.

Primary data:
- Per-position master table — within-class conservation, between-class Jensen–Shannon divergence, and the specificity-anomaly score (S_sdp) for every structurally equivalent position of each family studied (class A GPCR coupling, serine proteases, protein kinases).
- Figure-generation code and the conservation–divergence spectrum pipeline (alignment to Pfam profile HMM, Henikoff position-based weighting, JSD normalized by log2 of the number of classes, conservation-binned anomaly scoring).

Source data: class A GPCR sequences and G-protein coupling assignments from GtoPdb/GPCRdb; serine protease and protein kinase families from Pfam. All source sequences are publicly available from their respective databases under the accession codes listed in the supplementary master table.

Analysis code (the shared conservation-divergence spectrum instrument plus all P1 driver scripts) is archived on Zenodo: https://doi.org/10.5281/zenodo.21449958 (shared with companion preprints P2 and P3, which use the same instrument).

Companion preprints P2 (applicability criterion) and P3 (protein-language-model cross-examination) (Research Square, 2026; DOIs to be added on posting).