Analysis completed: 2026-07-29 00:28:43 UTC
Bulk significance definition: dataset-level BH-adjusted P < 0.05; no additional effect-size threshold.
Pseudobulk inputs: pre-existing donor-level PyDESeq2 results for eight prespecified hub genes.

R version 4.5.2 (2025-10-31)
Platform: aarch64-apple-darwin25.0.0
Running under: macOS Tahoe 26.1

Matrix products: default
BLAS:   /opt/homebrew/Cellar/openblas/0.3.31/lib/libopenblasp-r0.3.31.dylib 
LAPACK: /opt/homebrew/Cellar/r/4.5.2_1/lib/R/lib/libRlapack.dylib;  LAPACK version 3.12.1

locale:
[1] C.UTF-8/C.UTF-8/C.UTF-8/C/C.UTF-8/C.UTF-8

time zone: America/Chicago
tzcode source: internal

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
[1] ggplot2_4.0.3     data.table_1.18.4

loaded via a namespace (and not attached):
 [1] labeling_0.4.3     RColorBrewer_1.1-3 R6_2.6.1           tidyselect_1.2.1  
 [5] farver_2.1.2       magrittr_2.0.5     gtable_0.3.6       glue_1.8.1        
 [9] tibble_3.3.1       dichromat_2.0-0.1  pkgconfig_2.0.3    dplyr_1.2.1       
[13] generics_0.1.4     lifecycle_1.0.5    cli_3.6.6          S7_0.2.2          
[17] viridisLite_0.4.3  scales_1.4.0       grid_4.5.2         vctrs_0.7.3       
[21] withr_3.0.3        compiler_4.5.2     pillar_1.11.1      rlang_1.2.0       
