Subject: Request for isolate-level CRyPTIC variant calls for genetic-relatedness validation

Dear CRyPTIC data access team,

We are conducting a secondary analysis of paired rifampicin/rifabutin phenotype and whole-genome data. We request access to isolate-level, quality-controlled VCF/callable-site information for the UNIQUEIDs in our locked analysis cohort. The purpose is restricted to:

1. masked core-genome pairwise SNP distances;
2. 5-SNP and 12-SNP connected-component clustering;
3. nearest training-neighbour distance auditing across validation folds; and
4. genetic-cluster-grouped internal validation.

We will not interpret these clusters as epidemiologically confirmed transmission without the relevant metadata. We will comply with CRyPTIC access, acknowledgement, and data-use requirements.

Required identifier: CRyPTIC UNIQUEID.

Sincerely,
[Corresponding author and institution]
