Supplementary legends
Supplementary Table S1. Differentially expressed genes between T2DM and control peripheral blood samples.
This supplementary table lists the significantly differentially expressed genes identified from the overall single-cell transcriptomic comparison between T2DM and control groups, including statistical significance, log2 fold change, and expression proportions. 

Supplementary Table S2. Cell type-specific differentially expressed genes between T2DM and control samples.
This supplementary material summarizes the differentially expressed genes identified within each major immune cell lineage, including B cells, CD4⁺ T cells, CD8⁺ T cells, dendritic cells, HSC G-CSF-like cells, monocytes, neutrophils, and NK cells, providing cell type-resolved transcriptional alterations associated with T2DM.

Supplementary Table S3. Comprehensive ligand–receptor interaction network among peripheral immune cells in T2DM


Supplementary Table S4. Summary of interaction counts across communication categories (cell–cell contact, secreted signaling, and ECM–receptor)

Supplementary Table S5. Summary of communication strength across interaction categories in T2DM immune microenvironment