# 完整References列表(含in-text引用映射)

原稿References只有4条且含"to verify"/"to format"占位符。以下为补全版,但**验证状态需要
如实区分**:仅3条(4/5/6)本次实际执行了web_search核实;其余11条(含条目1/2/3等核心
背景文献,以及全部方法学工具引用)是基于训练知识回忆写出的完整引用信息,**尚未经过
本次会话的独立检索确认**,存在作者拼写、卷期页码或DOI错误的风险,投稿前必须逐条用
`fetch_article_fulltext`或PubMed/CrossRef核实。

## 核心背景文献(⚠️ 未在本次会话中web核实,仅为训练知识回忆,投稿前必须核实)

1. **Kling RC, Clark T, Gmeiner P** (2016). Comparative MD simulations indicate a dual
   role for Arg3.50 in class A GPCR activation. *PLoS ONE* 11(1):e0146612.
   doi:10.1371/journal.pone.0146612.
   — in-text: Introduction(34%统计出处), Discussion — **未核实,投稿前需确认**

2. **Hauser AS, Kooistra AJ, Munk C, et al.** (2021). GPCR activation mechanisms across
   classes and macro/microscales. *Nat Struct Mol Biol* 28:879-888.
   doi:10.1038/s41594-021-00674-7.
   — in-text: Introduction(25-31%保守率统计出处) — **未核实,投稿前需确认**

3. **Ellaithy A, Gonzalez-Maeso J, Logothetis DE, Levitz J** (2020). Structural and
   biophysical mechanisms of class C GPCR function. *Trends Biochem Sci* 45(12):1049-1064.
   doi:10.1016/j.tibs.2020.07.008.
   — in-text: Discussion(class C对比段落) — **未核实,投稿前需确认**

## 替代-lock机制文献(✅ 本次会话已用web_search核实完整出处)

4. **Springael JY, de Poorter C, Deupi X, Van Durme J, Pardo L, Parmentier M** (2007).
   The activation mechanism of chemokine receptor CCR5 involves common structural
   changes but a different network of interhelical interactions relative to rhodopsin.
   *Cell Signal* 19(7):1446-1456. doi:10.1016/j.cellsig.2007.01.022. [PMID:17320349]
   — **已核实**(web_search确认)。注:candidateA_literature_check.md原标注此文为
   "2002年研究",经核实实际发表于2007年,已订正。

5. **Schneider EH, Schnell D, Strasser A, Dove S, Seifert R** (2010). Impact of the
   DRY motif and the missing "ionic lock" on constitutive activity and G-protein
   coupling of the human histamine H4 receptor. *J Pharmacol Exp Ther* 333(2):382-392.
   doi:10.1124/jpet.109.163220.
   — **已核实**(web_search确认)

6. **[作者列表未完全核实]** (2019). Towards A Molecular Understanding of The
   Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity.
   *Int J Mol Sci* 20(9):2300. doi:10.3390/ijms20092300. [PMC6539512]
   — 期刊/年份/DOI已通过web_search确认存在,但**具体作者姓名列表本次会话未逐一核实**,
   投稿前需读取PMC6539512全文确认作者。

## 方法学工具文献(⚠️ 未在本次会话中web核实,仅为训练知识回忆,投稿前必须核实)

7. **Pagel M** (1994). Detecting correlated evolution on phylogenies: a general method
   for the comparison of discrete characters. *Proc R Soc Lond B* 255:37-45.
   — **未核实,投稿前需确认**(fitPagel方法学出处)

8. **Revell LJ** (2012). phytools: An R package for phylogenetic comparative biology
   (and other things). *Methods Ecol Evol* 3:217-223.
   — **未核实,投稿前需确认**

9. **Beaulieu JM, O'Meara BC, Donoghue MJ** (2013). Identifying hidden rate changes in
   the evolution of a binary morphological character. *Syst Biol* 62(5):725-737.
   — **未核实,投稿前需确认**(corHMM方法学出处)

10. **Steenwyk JL, Rokas A** — DISCO算法原始文献。**本次会话明确未核实**,连基本
    出处(期刊/年份)都需要投稿前重新检索确认,不应视为可用引用。

11. **Munk C, Isberg V, Mordalski S, et al.** (2016). GPCRdb: the G protein-coupled
    receptor database. *Br J Pharmacol* 173(14):2195-2207.
    — **未核实,投稿前需确认**

12. **Berman HM, Westbrook J, Feng Z, et al.** (2000). The Protein Data Bank.
    *Nucleic Acids Res* 28(1):235-242.
    — **未核实,投稿前需确认**

13. **Jumper J, Evans R, Pritzker A, et al.** (2021). Highly accurate protein structure
    prediction with AlphaFold. *Nature* 596:583-589.
    — **未核实,投稿前需确认**

14. **Pedregosa F, et al.** (2011). Scikit-learn: Machine Learning in Python.
    *J Mach Learn Res* 12:2825-2830.
    — **未核实,投稿前需确认**

## 投稿前必须完成的核实工作(如实说明,不再声称"全部已核实")

本列表14条中,**仅3条(4/5)完整核实、条目6部分核实**,其余10条(1/2/3/7-14)完全依赖
训练知识回忆写出,包含真实存在概率很高的知名文献(如Pagel 1994、AlphaFold 2021、
GPCRdb 2016),但具体卷期页码/DOI可能有误,**投稿前必须逐条用`fetch_article_fulltext`
或CrossRef/PubMed API核实**,不能直接以当前状态提交。这是本次revision尚未完成的工作,
不应被此前的复核记录或步骤备注误报为"已核实"。