"top150_rank"	"perturbagen"	"broad_pert_id"	"l1000fwd_score"	"cell_line"	"perturbation_time_h"	"perturbation_dose"	"nominal_pvalue"	"signature_id"	"moa_class"	"putative_target_or_pathway"	"annotation_confidence"	"interpretation_note"
"1"	"ESTRONE"	"BRD-A37959677"	"-0.192982456140351"	"VCAP"	"24"	"10.0"	"0.0084"	"CPC005_VCAP_24H:BRD-A37959677-001-03-7:10"	"Hormone receptor ligand"	"ESR1/ESR2"	"Moderate"	"Endogenous estrogen; interpret cautiously."
"3"	"ALTRENOGEST"	"BRD-A27554692"	"-0.175438596491228"	"VCAP"	"24"	"10.0"	"0.0"	"CPC004_VCAP_24H:BRD-A27554692-001-01-3:10"	"Progestin / progesterone receptor agonist"	"PGR"	"Moderate"	"Veterinary progestin; not a direct therapeutic recommendation."
"4"	"QUINIDINE GLUCONATE"	"BRD-K59632282"	"-0.164912280701754"	"HCC515"	"24"	"10.0"	"0.0049"	"CPC003_HCC515_24H:BRD-K59632282-052-02-3:10"	"Ion-channel blocker / antiarrhythmic"	"SCN5A; potassium channels"	"Moderate"	"Clinical safety considerations; not prioritized as therapeutic claim."
"5"	"(-)-Gallocatechin gallate"	"BRD-K19216856"	"-0.157894736842105"	"A549"	"6"	"88.8"	"0.0"	"CPC006_A549_6H:BRD-K19216856-001-02-7:88.8"	"Polyphenol / bioactive natural compound"	"Pleiotropic; no single primary target assigned"	"Moderate"	"Do not overstate as target-specific."
"7"	"Beclomethasone dipropionate"	"BRD-K97810537"	"-0.147368421052632"	"HCC515"	"6"	"10.0"	"0.0007"	"CPC002_HCC515_6H:BRD-K97810537-001-03-7:10"	"Glucocorticoid receptor agonist"	"NR3C1"	"High"	"Clinically used corticosteroid; independent corticosteroid hit."
"8"	"LY-2183240"	"BRD-K37865504"	"-0.143859649122807"	"A375"	"24"	"10.0"	"0.0"	"CPC006_A375_24H:BRD-K37865504-001-02-5:10"	"Endocannabinoid-pathway inhibitor"	"FAAH / anandamide uptake"	"Moderate"	"Mechanistic annotation should be verified experimentally."
"9"	"L-690,488"	"BRD-K69328504"	"-0.140350877192982"	"VCAP"	"24"	"10.0"	"0.0"	"CPC006_VCAP_24H:BRD-K69328504-001-01-7:10"	"Experimental or unclear"	"Not confidently assigned"	"Low"	"No reliable MoA assigned from the current result table."
"10"	"PLX-4032"	"BRD-K56343971"	"-0.140350877192982"	"HT29"	"24"	"10.0"	"0.0"	"CPC006_HT29_24H:BRD-K56343971-001-02-3:10"	"Kinase inhibitor"	"BRAF"	"High"	"Also known as vemurafenib."
"11"	"ofloxacin"	"BRD-A24228527"	"-0.140350877192982"	"VCAP"	"6"	"10.0"	"0.0063"	"CPC020_VCAP_6H:BRD-A24228527-001-27-3:10"	"Fluoroquinolone antibacterial"	"Bacterial DNA gyrase/topoisomerase IV"	"High"	"Lower biological priority for CRC mechanism."
"13"	"H7270"	"BRD-A39646320"	"-0.136842105263158"	"A549"	"24"	"10.0"	"0.0"	"CPC014_A549_24H:BRD-A39646320-001-01-3:10"	"Experimental or unclear"	"Not confidently assigned"	"Low"	"No reliable MoA assigned from the current result table."
"16"	"Dexamethasone"	"BRD-A35108200"	"-0.136842105263158"	"SKLU1"	"6"	"10.0"	"0.0049"	"CPC006_SKLU1_6H:BRD-A35108200-001-04-7:10"	"Glucocorticoid receptor agonist"	"NR3C1"	"High"	"Clinically used corticosteroid; treat as computational drug-repurposing signal."
"19"	"BTB06091SC"	"BRD-K82685933"	"-0.136842105263158"	"VCAP"	"24"	"10.0"	"0.0"	"CPC013_VCAP_24H:BRD-K82685933-001-02-2:10"	"Experimental or unclear"	"Not confidently assigned"	"Low"	"No reliable MoA assigned from the current result table."
"20"	"HDAC6 inhibitor ISOX"	"BRD-K69840642"	"-0.136842105263158"	"DV90"	"6"	"10.0"	"0.0"	"CPC006_DV90_6H:BRD-K69840642-001-01-4:10"	"Epigenetic enzyme inhibitor"	"HDAC6"	"High"	"Top150 reverse signature."
"22"	"NCGC00184834-01"	"BRD-K32944375"	"-0.133333333333333"	"HCC515"	"6"	"10.0"	"0.0"	"CPC008_HCC515_6H:BRD-K32944375-019-01-3:10"	"Experimental or unclear"	"Not confidently assigned"	"Low"	"No reliable MoA assigned from the current result table."
"23"	"JAK3 Inhibitor I"	"BRD-K72541103"	"-0.133333333333333"	"HCC515"	"24"	"10.0"	"0.0"	"CPC001_HCC515_24H:BRD-K72541103-001-01-5:10"	"Kinase inhibitor"	"JAK3"	"High"	"Appeared in Top100/Top150."
"25"	"S1170"	"BRD-K73293050"	"-0.133333333333333"	"SKB"	"24"	"10.0"	"0.0"	"CPC014_SKB_24H:BRD-K73293050-001-01-5:10"	"Experimental or unclear"	"Not confidently assigned"	"Low"	"No reliable MoA assigned from the current result table."
"26"	"AS605240"	"BRD-K41895714"	"-0.133333333333333"	"A375"	"24"	"10.0"	"0.0"	"CPC006_A375_24H:BRD-K41895714-001-02-2:10"	"Kinase inhibitor"	"PI3K gamma"	"Moderate"	"Appeared in Top150."
"27"	"Mometasone furoate"	"BRD-K60640630"	"-0.133333333333333"	"HCC515"	"6"	"10.0"	"0.0037"	"CPC002_HCC515_6H:BRD-K60640630-001-03-7:10"	"Glucocorticoid receptor agonist"	"NR3C1"	"High"	"Appeared in Top150 reverse signatures but not all sensitivity sets."
"28"	"epitestosterone"	"BRD-K25836724"	"-0.133333333333333"	"VCAP"	"24"	"10.0"	"0.0"	"CPC004_VCAP_24H:BRD-K25836724-001-01-6:10"	"Steroid hormone"	"Androgen receptor-related"	"Low"	"Annotation is broad; target should be verified before mechanistic claims."
"29"	"HY-10192"	"BRD-K50140147"	"-0.129824561403509"	"SKB"	"24"	"10.0"	"0.0"	"CPC013_SKB_24H:BRD-K50140147-001-03-6:10"	"Experimental or unclear"	"Not confidently assigned"	"Low"	"No reliable MoA assigned from the current result table."
"31"	"PEITC"	"BRD-K56700933"	"-0.129824561403509"	"SW620"	"6"	"10.0"	"0.0007"	"CPC006_SW620_6H:BRD-K56700933-001-01-3:10"	"Isothiocyanate bioactive compound"	"Pleiotropic stress-response pathways"	"Moderate"	"Appeared in Top100/Top150."
"32"	"AG 494"	"BRD-K34533029"	"-0.129824561403509"	"HA1E"	"6"	"10.0"	"0.0098"	"CPC001_HA1E_6H:BRD-K34533029-001-01-0:10"	"Kinase inhibitor"	"EGFR"	"Moderate"	"Tyrphostin EGFR inhibitor annotation."
"35"	"HDAC6 inhibitor ISOX"	"BRD-K69840642"	"-0.126315789473684"	"VCAP"	"24"	"10.0"	"0.0"	"CPC006_VCAP_24H:BRD-K69840642-001-01-4:10"	"Epigenetic enzyme inhibitor"	"HDAC6"	"High"	"Top150 reverse signature."
"38"	"cefixime"	"BRD-K04993501"	"-0.126315789473684"	"A549"	"6"	"10.0"	"0.0063"	"CPC010_A549_6H:BRD-K04993501-002-01-7:10"	"Experimental or unclear"	"Not confidently assigned"	"Low"	"No reliable MoA assigned from the current result table."
"39"	"HY-10234"	"BRD-K19540840"	"-0.126315789473684"	"SKB"	"24"	"10.0"	"0.0"	"CPC014_SKB_24H:BRD-K19540840-001-02-9:10"	"Experimental or unclear"	"Not confidently assigned"	"Low"	"No reliable MoA assigned from the current result table."
"40"	"PD 98059"	"BRD-K62810658"	"-0.12280701754386"	"A375"	"6"	"10.0"	"0.0"	"CPC006_A375_6H:BRD-K62810658-001-06-4:10"	"Kinase pathway inhibitor"	"MEK/MAPK pathway"	"High"	"Appeared in Top100/Top150."
"41"	"K3644"	"BRD-A67748489"	"-0.12280701754386"	"MCF7"	"24"	"10.0"	"0.0063"	"CPC014_MCF7_24H:BRD-A67748489-001-06-8:10"	"Experimental or unclear"	"Not confidently assigned"	"Low"	"No reliable MoA assigned from the current result table."
"42"	"megestrol"	"BRD-K19507340"	"-0.12280701754386"	"A549"	"6"	"10.0"	"0.0105"	"CPC011_A549_6H:BRD-K19507340-001-18-9:10"	"Progestin / progesterone receptor agonist"	"PGR"	"Moderate"	"Appeared in Top150 reverse signatures."
"43"	"TG101348"	"BRD-K12502280"	"-0.12280701754386"	"HCC515"	"24"	"11.1"	"0.0"	"CPC006_HCC515_24H:BRD-K12502280-001-01-5:11.1"	"Kinase inhibitor"	"JAK2/FLT3"	"High"	"Also known as fedratinib."
"44"	"PENITREM A"	"BRD-K03842655"	"-0.12280701754386"	"HT29"	"6"	"10.0"	"0.0"	"CPC004_HT29_6H:BRD-K03842655-001-02-1:10"	"Experimental or unclear"	"Not confidently assigned"	"Low"	"No reliable MoA assigned from the current result table."