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{"sheet":"Table S1","index":0,"n_rows":57,"n_cols":9,"rows_kept":57,"merged":[[3,1,17,1],[18,1,54,1],[55,1,55,8],[56,1,56,8]],"flags":["formulas_cached_only"]}
[]
[null,"Table S1. Baseline characteristics of COVID-19 patients included in this study."]
[null,null,"ID","Age/sex","Underlyng disorders*","Severity","Pneumonia","Treatment**","Oxygen therapy***"]
[null,"Group 1",1,"36/M","x","mild","x","Hydroxychroroquine (5 D)","x"]
[null,null,2,"29/F","x","mild","mild","x","x"]
[null,null,3,"30/M","HTN","mild","mild","x","x"]
[null,null,4,"30/M","x","mild","mild","x","x"]
[null,null,5,"64/F","x","mild","mild","x","x"]
[null,null,6,"61/M","x","mild","mild","x","x"]
[null,null,7,"46/M","HTN","mild","mild","Lopinavir-ritonavir (9 D)","x"]
[null,null,8,"74/M","HTN, DM, BPH","mild","mild","Lopinavir-ritonavir (10 D)","x"]
[null,null,9,"75/F","HTN","mild","moderate","Lopinavir-ritonavir (10 D), Hydroxychroroquine (5 D), Methylprednisolone (6 D)","Nasal cannula"]
[null,null,10,"61/F","x","mild","moderate","Lopinavir-ritonavir (10 D)","Nasal cannula"]
[null,null,11,"79/M","HTN, DM","severe","severe","Lopinavir-ritonavir (11 D), Methylprednisolone (>10 D)","MV"]
[null,null,12,"79/F","HTN, DM, old PTB, GBS","severe","severe","Lopinavir-ritonavir (10 D), Methylprednisolone (>10 D)","MV"]
[null,null,13,"62/M","Schizophrenia","severe","severe","Lopinavir-ritonavir (14 D), Hydrocortisone (3 D), Prednisolone (>10 D)","MV, ECMO"]
[null,null,14,"41/M","Gout, DM","severe","severe","Lopinavir-ritonavir (3 D), Darunavir/cobicistat (7 D)","MV, ECMO"]
[null,null,15,"68/F","HTN","severe","fatal","Lopinavir-ritonavir (3 D), Methylprednisolone (>20 D)","MV, ECMO"]
[null,"Group 2",16,"66/F","HTN","mild","x","x","x"]
[null,null,17,"81/F","DM","mild","x","x","x"]
[null,null,18,"63/F","HTN","mild","x","x","x"]
[null,null,19,"77/F","dementia","mild","mild","x","x"]
[null,null,20,"70/F","x","mild","mild","x","x"]
[null,null,21,"35/F","x","mild","mild","x","x"]
[null,null,22,"59/M","HTN, DM, dyslipidemia","mild","mild","Dexamethasone (3 D)","x"]
[null,null,23,"62/M","old PTB","mild","mild","Dexamethasone (6D)","x"]
[null,null,24,"68/F","DM","mild","mild","x","x"]
[null,null,25,"54/F","x","mild","mild","x","x"]
[null,null,26,"51/M","DM, HTN","mild","mild","x","x"]
[null,null,27,"61/F","x","mild","mild","x","x"]
[null,null,28,"59/M","x","mild","mild","x","x"]
[null,null,29,"65/M","x","mild","mild","x","x"]
[null,null,30,"63/F","DM","mild","mild","x","x"]
[null,null,31,"49/F","x","mild","mild","x","x"]
[null,null,32,"63/F","Dyslipidemia","mild","mild","x","x"]
[null,null,33,"65/F","x","mild","mild","x","x"]
[null,null,34,"69/F","x","mild","mild","x","x"]
[null,null,35,"68/F","HTN, DM","mild","moderate","x","x"]
[null,null,36,"89/F","dementia","mild","moderate","x","Nasal cannula"]
[null,null,37,"93/F","HTN, MDD","mild","moderate","Remdesivir (D5)","Nasal cannula"]
[null,null,38,"64/F","HTN","mild","moderate","Remdesivir (D5)","Nasal cannula"]
[null,null,39,"70/F","DM, HTN, thyroid cancer","mild","moderate","Dexamethasone (3 D)","Nasal cannula"]
[null,null,40,"66/F","DM","mild","moderate","Dexamethasone (10 D)","Nasal cannula"]
[null,null,41,"57/F","x","mild","moderate","Dexamethasone (5 D)","Nasal cannula"]
[null,null,42,"56/M","HTN","severe","severe","Remdesivir (D5)","HFNC"]
[null,null,43,"77/M","x","severe","severe","Remdesivir(>10 D)","MV"]
[null,null,44,"51/M","Dyslipidemia","severe","severe","Remdesivir(D5), Dexamethasone (D4)","HFNC"]
[null,null,45,"65/M","DM, HTN, CKD","severe","severe","Lopinavir-ritonavir (16 D), Darunavir/cobicistat (5 D), Hydrocortisone (2 D), Methylprednisolone (> 10D)","MV, ECMO"]
[null,null,46,"58/M","DM","severe","severe","Dexamethasone (10 D)","MV"]
[null,null,47,"70/F","DM, HTN,  paroxy는","severe","severe","Dexamethasone (>10D)","MV"]
[null,null,48,"72/F","DM, Asthma","severe","severe","Dexamethasone (10 D)","MV"]
[null,null,49,"73/M","x","severe","severe","Dexamethasone (>10D)","MV"]
[null,null,50,"64/M","HTN, Chronic HBV","severe","severe","Dexamethasone (10 D)","MV"]
[null,null,51,"60/M","HTN, prostatic cancer, Angina, spinal stenosis ","severe","severe","Dexamethasone (10 D)","MV"]
[null,null,52,"64/F","HTN","severe","severe","Nafamostat (3D), Dexamethasone (10 D)","MV"]
[null,"* HTN: Hypertension, DM: Diabetes mellitus, BPH: Benign prostatic hyperplasia, PTB: Pulmonary tuberculosis, GBS: Guillain barre syndrome, MDD: major depressive disorder, CKD: Chronic kidney disease"]
[null,"** D: days.; *** MV: mechanical ventilation, ECMO: extracorporeal membrane oxygenation."]

{"sheet":"Table S2","index":1,"n_rows":58,"n_cols":10,"rows_kept":58,"merged":[[2,1,3,1],[2,2,3,2],[2,3,3,3],[2,4,3,4],[2,5,3,5],[2,6,2,9],[50,6,50,9]],"flags":["formulas_cached_only"]}
[]
[null,"Table S2. Summary of cytological analysis of sputa and BALFs by hematoxylin and eosin (H&E) staining."]
[null,"Patients' ID.","Sample type","Severity","DPS*","Denstity of inflammatory cells**","% in inflammatory cells"]
[{"$nulls":6},"macrophages","PMN","lymphocytes","eosinophils"]
[null,1,"Sputum","mild",3,3,1,99,0,0]
[null,5,"BALF","mild",20,3,30,10,60,0]
[null,6,"BALF","mild",8,1,20,75,5,0]
[null,10,"Sputum","mild",9,1,40,40,5,15]
[null,10,"Sputum","mild",21,1,50,0,50,0]
[null,18,"Sputum","mild",6,1,5,85,0,10]
[null,19,"Sputum","mild",3,2,40,45,5,10]
[null,20,"Sputum","mild",10,3,40,45,10,5]
[null,23,"Sputum","mild",10,1,20,35,40,5]
[null,25,"Sputum","mild",7,3,90,5,5,0]
[null,26,"Sputum","mild",8,1,15,5,40,40]
[null,27,"Sputum","mild",5,1,50,30,5,15]
[null,28,"Sputum","mild",8,3,30,55,15,0]
[null,36,"Sputum","mild",1,3,5,80,10,5]
[null,36,"Trachea suction","mild",8,2,25,70,0,5]
[null,37,"Sputum","mild",4,3,85,10,5,0]
[null,38,"Sputum","mild",12,3,80,5,15,0]
[null,39,"Sputum","mild",4,3,70,5,20,5]
[null,39,"Sputum","mild",15,3,10,85,5,0]
[null,41,"Sputum","mild",5,2,65,25,5,5]
[null,11,"BALF","severe",12,3,35,45,20,0]
[null,11,"Sputum","severe",12,3,3,97,0,0]
[null,12,"Sputum","severe",2,3,5,90,5,0]
[null,12,"BALF","severe",15,3,10,75,10,5]
[null,12,"Sputum","severe",31,2,10,90,0,0]
[null,13,"BALF","severe",10,2,95,0,5,0]
[null,14,"Sputum","severe",8,3,85,5,10,0]
[null,14,"BALF","severe",14,1,95,0,5,0]
[null,14,"BALF","severe",20,2,85,0,10,5]
[null,14,"BALF","severe",26,3,85,5,10,0]
[null,15,"BALF","severe",30,3,10,75,15,0]
[null,15,"BALF","severe",36,3,55,20,25,0]
[null,15,"Sputum","severe",48,3,15,50,35,0]
[null,42,"Sputum","severe",9,3,45,50,5,0]
[null,42,"Sputum","severe",16,2,40,50,5,5]
[null,43,"Trachea suction","severe",10,3,5,90,0,5]
[null,44,"Sputum","severe",12,3,60,30,0,10]
[null,44,"Sputum","severe",12,3,5,80,10,5]
[null,46,"Sputum","severe",4,3,84,0,15,1]
[null,46,"Sputum","severe",15,3,5,90,5,0]
[null,47,"Sputum","severe",15,3,5,80,15,0]
[null,48,"Sputum","severe",19,3,5,60,30,5]
[null,49,"Sputum","severe",18,3,5,85,5,5]
[null,50,"Sputum","severe",12,2,5,75,0,20]
[null,51,"Sputum","severe",14,1,5,85,5,5]
[null,"*, DPS: days post symptom onset, **, 1: a few; 2, intermediate; 3, high"]
[{"$nulls":6},"% in inflammatory cells"]
[{"$nulls":6},"macrophages","PMN","lymphocytes","eosinophils"]
[{"$nulls":3},"Mild",null,"mean",{"v":38.55,"d":"38.6"},{"v":40.45,"d":"40.5"},{"v":15,"d":"15.0"},{"v":6,"d":"6.0"}]
[{"$nulls":5},"S.D.",{"v":27.652876504034232,"d":"27.7"},{"v":32.587493564895496,"d":"32.6"},{"v":17.84435632438388,"d":"17.8"},{"v":9.403246919632545,"d":"9.4"}]
[{"$nulls":3},"Severe",null,"mean",{"v":34.28,"d":"34.3"},{"v":53.08,"d":"53.1"},9.8,{"v":2.84,"d":"2.8"}]
[{"$nulls":5},"S.D.",{"v":35.14081198075347,"d":"35.1"},{"v":35.338741724439856,"d":"35.3"},{"v":9.40744386111339,"d":"9.4"},{"v":4.561432523524454,"d":"4.6"}]
[{"$nulls":3},"Total",null,"mean",{"v":37.48780487804878,"d":"37.5"},{"v":46.63414634146341,"d":"46.6"},{"v":11.585365853658537,"d":"11.6"},{"v":4.2926829268292686,"d":"4.3"}]
[{"$nulls":5},"S.D.",{"v":32.690305865209886,"d":"32.7"},{"v":34.28538762910591,"d":"34.3"},{"v":12.167529761122628,"d":"12.2"},{"v":7.280947405520193,"d":"7.3"}]

{"sheet":"Table S3","index":2,"n_rows":34,"n_cols":42,"rows_kept":34,"merged":[[2,2,2,12],[2,13,2,32],[2,35,2,36],[2,37,2,38],[2,39,2,40]],"flags":["formulas_cached_only"]}
[]
[null,"Table S3. Raw data of 28 cytokines, chemokines, and inflammatory mediators measured in respiratory specimens collected from COVID-19 patients.* "]
[null,null,"Mild",{"$nulls":10},"Severe",{"$nulls":21},"Mild (n = 11)",null,"Severe (n = 20)",null,"Total (n = 31)",null,"Mann-Whitney test (p)"]
[null,"DPS",3,1,12,20,8,0,12,9,16,21,23,12,19,22,2,13,22,4,34,38,39,7,8,13,14,20,27,8,16,26,30]
[null,"Inflammatory mediators","P1/D3/SPT**","P3/D1/SPT","P3/D12/SPT","P5/D20/BAL***","P6/D8/BAL","P7/D0/SPT","P7/D12/SPT","P10/D9/SPT","P10/D16/SPT","P10/D21/BAL","P10/D23/SPT","P11/D12/BAL","P11/D19/BAL","P11/D22/SPT","P12/D2/SPT","P12/D13/BAL","P12/D22/SPT","P13/D4/BAL","P13/D34/SPT","P13/D38/BAL","P13/D39/BAL","P14/D7/SPT","P14/D8/BAL","P14/D13/BAL","P14/D14/BAL","P14/D20/BAL","P14/D27/BAL","P15/D8/BAL","P15/D16/BAL","P15/D26/BAL","P15/D30/BAL",null,"Inflammatory mediators","Mean","S.D.","Mean","S.D.","Mean","S.D."]
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[null,"TNF-a (pg/ml)",{"v":2000,"d":"2000.00"},1.48,{"v":0,"d":"0.00"},7.78,26.04,{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},13.63,67.72,{"v":0,"d":"0.00"},79.08,16.68,{"v":0,"d":"0.00"},32.14,151.15,{"v":0,"d":"0.00"},302.51,65.08,170.06,{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},9.02,{"v":8,"d":"8.00"},1.74,{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},1986.35,22.25,{"v":0,"d":"0.00"},{"v":0,"d":"0.00"},null,"TNF-a (pg/ml)",{"v":199.61181818181814,"d":"199.6"},{"v":597.7852929408381,"d":"597.8"},{"v":138.249,"d":"138.2"},{"v":442.052609847099,"d":"442.1"},{"v":160.02290322580643,"d":"160.0"},{"v":493.727131569612,"d":"493.7"},{"v":0.847,"d":"0.8470"}]
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[null,"* Data over the detection limit are indicated in bold.; ** SPT: sputum; *** BAL: bronchoalvelolar lavage"]